Experts and Doctors on peptide initiation factors in Paris, Île de France, France


Locale: Paris, Île de France, France
Topic: peptide initiation factors

Top Publications

  1. Shazand K, Tucker J, Grunberg Manago M, Rabinowitz J, Leighton T. Similar organization of the nusA-infB operon in Bacillus subtilis and Escherichia coli. J Bacteriol. 1993;175:2880-7 pubmed
    ..subtilis infB operons suggests that the function of each gene pair is conserved and that the B. subtilis NusA homolog, which is 124 residues shorter than its E. coli counterpart, could play a role similar to its role in E. coli. ..
  2. Laalami S, Sacerdot C, Vachon G, Mortensen K, Sperling Petersen H, Cenatiempo Y, et al. Structural and functional domains of E coli initiation factor IF2. Biochimie. 1991;73:1557-66 pubmed
    ..Here we review evidence which indicates the functional importance of the different structural domains of IF2, emphasizing new information obtained by in vivo experiments. ..
  3. Lesage P, Chiaruttini C, Graffe M, Dondon J, Milet M, Springer M. Messenger RNA secondary structure and translational coupling in the Escherichia coli operon encoding translation initiation factor IF3 and the ribosomal proteins, L35 and L20. J Mol Biol. 1992;228:366-86 pubmed
  4. Shazand K, Tucker J, Chiang R, Stansmore K, Sperling Petersen H, Grunberg Manago M, et al. Isolation and molecular genetic characterization of the Bacillus subtilis gene (infB) encoding protein synthesis initiation factor 2. J Bacteriol. 1990;172:2675-87 pubmed
    ..subtilis chromosome, between the polC and spcB loci. This location is distinct from those of the other major ribosomal protein and rRNA gene clusters of B. subtilis. ..
  5. Lesage P, Truong H, Graffe M, Dondon J, Springer M. Translated translational operator in Escherichia coli. Auto-regulation in the infC-rpmI-rplT operon. J Mol Biol. 1990;213:465-75 pubmed
    ..The possible competition between translation of the regions acting in cis and the regulation of the expression of the target gene is discussed. ..
  6. Regnier P, Grunberg Manago M. Cleavage by RNase III in the transcripts of the met Y-nus-A-infB operon of Escherichia coli releases the tRNA and initiates the decay of the downstream mRNA. J Mol Biol. 1989;210:293-302 pubmed
  7. Sacerdot C, Chiaruttini C, Engst K, Graffe M, Milet M, Mathy N, et al. The role of the AUU initiation codon in the negative feedback regulation of the gene for translation initiation factor IF3 in Escherichia coli. Mol Microbiol. 1996;21:331-46 pubmed
    ..On the basis of our in vivo results we propose, as suspected from earlier in vitro results, that IF3 regulates the expression of its own gene by using its ability to differentiate between 'normal' and 'abnormal' initiation codons. ..
  8. Catoire H, Pasco M, Abu Baker A, Holbert S, Tourette C, Brais B, et al. Sirtuin inhibition protects from the polyalanine muscular dystrophy protein PABPN1. Hum Mol Genet. 2008;17:2108-17 pubmed publisher
    ..Altogether, our data identify Sir2 and AMPK inhibition as therapeutic strategies for muscle protection in OPMD, extending the value of druggable proteins in cell maintenance networks to polyalanine diseases...
  9. Chiaruttini C, Milet M, de Smit M, Springer M. Translational coupling in the Escherichia coli operon encoding translation initiation factor IF3 and ribosomal proteins L20 and L35. Biochimie. 1996;78:555-67 pubmed
    ..In vitro 'toeprinting' analysis enabled us to show that the wild-type inhibitory secondary structure directly blocks ribosome binding to the ribosome binding site of rpIT. ..

More Information


  1. Grolleau A, Wietzerbin J, Beretta L. Defect in the regulation of 4E-BP1 and 2, two repressors of translation initiation, in the retinoid acid resistant cell lines, NB4-R1 and NB4-R2. Leukemia. 2000;14:1909-14 pubmed
    ..This indicates that 4E-BP1 down-regulation is associated with granulocytic maturation, whereas post-transcriptional regulation of 4E-BP2 expression is associated with the early action of RA. ..
  2. Borman A, Kean K. Intact eukaryotic initiation factor 4G is required for hepatitis A virus internal initiation of translation. Virology. 1997;237:129-36 pubmed
    ..Thus the HAV IRES requires intact eIF4G for activity. This is unique among the picornavirus IRESes studied to date and may help explain why HAV does not inhibit host cell translation during viral infection. ..
  3. de Vanssay A, Bouge A, Boivin A, Hermant C, Teysset L, Delmarre V, et al. Paramutation in Drosophila linked to emergence of a piRNA-producing locus. Nature. 2012;490:112-5 pubmed publisher
    ..Our work provides a genetic model for the emergence of piRNA loci, as well as for RNA-mediated trans-generational repression of transposable elements...
  4. Caldas T, Laalami S, Richarme G. Chaperone properties of bacterial elongation factor EF-G and initiation factor IF2. J Biol Chem. 2000;275:855-60 pubmed
    ..These results suggest that EF-G and IF2, in addition to their role in translation, might be implicated in protein folding and protection from stress. ..
  5. Beretta L, Singer N, Hinderer R, Gingras A, Richardson B, Hanash S, et al. Differential regulation of translation and eIF4E phosphorylation during human thymocyte maturation. J Immunol. 1998;160:3269-73 pubmed
    ..These data provide evidence for differential regulation of the translational machinery during T cell development. ..
  6. Chiaruttini C, Milet M, Springer M. Translational coupling by modulation of feedback repression in the IF3 operon of Escherichia coli. Proc Natl Acad Sci U S A. 1997;94:9208-13 pubmed
    ..The result is a novel type of translational coupling, where unfolding of the pseudoknot by ribosomes translating IF3 does not increase expression of L35 directly, but alleviates its repression by L20. ..
  7. Chiaruttini C, Milet M, Springer M. A long-range RNA-RNA interaction forms a pseudoknot required for translational control of the IF3-L35-L20 ribosomal protein operon in Escherichia coli. EMBO J. 1996;15:4402-13 pubmed
    ..We propose that these two distant sites can base-pair to form a long-range pseudoknot which is required for the control of the expression of the L35 gene. ..
  8. Laalami S, Putzer H, Plumbridge J, Grunberg Manago M. A severely truncated form of translational initiation factor 2 supports growth of Escherichia coli. J Mol Biol. 1991;220:335-49 pubmed
    ..This result suggests that the catalytic properties are localized in the C-terminal half of the protein, which includes the G-domain, and that this fragment is sufficient to complement the IF2 deficiency in the infB deletion strain. ..