Genomes and Genes
Experts and Doctors on nuclear proteins in Paris, Île de France, France
Locale: Paris, Île de France, France
Topic: nuclear proteins
Publications319 found, 100 shown here
- Bach I, Yaniv M. More potent transcriptional activators or a transdominant inhibitor of the HNF1 homeoprotein family are generated by alternative RNA processing. EMBO J. 1993;12:4229-42 pubmed..Our studies show that the transactivation domain of the members of the HNF1 homeoprotein family is organized in modules which can be exchanged to generate either more potent transcriptional activators or a transdominant repressor. ..
- Geha S, Pallud J, Junier M, Devaux B, Leonard N, Chassoux F, et al. NG2+/Olig2+ cells are the major cycle-related cell population of the adult human normal brain. Brain Pathol. 2010;20:399-411 pubmed publisher..These results provide evidence for a persistent gliogenesis in the human cortex and white matter that is enhanced in an epileptic environment. ..
- Coumailleau P, Penrad Mobayed M, Lecomte C, Bollerot K, Simon F, Poellinger L, et al. Characterization and developmental expression of xSim, a Xenopus bHLH/PAS gene related to the Drosophila neurogenic master gene single-minded. Mech Dev. 2000;99:163-6 pubmed..As development proceeds, xSim is mainly restricted to the central nervous system. ..
- Belgareh N, Rabut G, Bai S, van Overbeek M, Beaudouin J, Daigle N, et al. An evolutionarily conserved NPC subcomplex, which redistributes in part to kinetochores in mammalian cells. J Cell Biol. 2001;154:1147-60 pubmed
- Coulet F, Nadaud S, Agrapart M, Soubrier F. Identification of hypoxia-response element in the human endothelial nitric-oxide synthase gene promoter. J Biol Chem. 2003;278:46230-40 pubmed..In conclusion, we demonstrate that heNOS is a hypoxia-inducible gene, whose transcription is stimulated through HIF-2 interaction with two contiguous HRE sites located at -5375 to -5366 of the heNOS promoter. ..
- Teixeira M, Siniossoglou S, Podtelejnikov S, Benichou J, Mann M, Dujon B, et al. Two functionally distinct domains generated by in vivo cleavage of Nup145p: a novel biogenesis pathway for nucleoporins. EMBO J. 1997;16:5086-97 pubmed..These data suggest that N- and C-domains of Nup145p perform independent functions, and that the in vivo cleavage observed is of functional importance. ..
- Callebaut I, Mornon J. The V(D)J recombination activating protein RAG2 consists of a six-bladed propeller and a PHD fingerlike domain, as revealed by sequence analysis. Cell Mol Life Sci. 1998;54:880-91 pubmed..Moreover, the presence of a plant homeodomain finger-like motif in the last quarter of the RAG2 sequence suggests a potential interaction of this domain with chromatin components. ..
- Moldes M, Boizard M, Liepvre X, Feve B, Dugail I, Pairault J. Functional antagonism between inhibitor of DNA binding (Id) and adipocyte determination and differentiation factor 1/sterol regulatory element-binding protein-1c (ADD1/SREBP-1c) trans-factors for the regulation of fatty acid synthase promoter in adip. Biochem J. 1999;344 Pt 3:873-80 pubmed..Taken together, our data show that Id products are functionally involved in modulating ADD1/SREBP-1c transcriptional activity, and thus lipogenesis in adipocytes. ..
- Terret M, Wassmann K, Waizenegger I, Maro B, Peters J, Verlhac M. The meiosis I-to-meiosis II transition in mouse oocytes requires separase activity. Curr Biol. 2003;13:1797-802 pubmed..We therefore investigated if Separase activity is required for correct chromosome segregation in meiosis I in mouse oocytes. ..
- Arango M, Holbert S, Zala D, Brouillet E, Pearson J, Regulier E, et al. CA150 expression delays striatal cell death in overexpression and knock-in conditions for mutant huntingtin neurotoxicity. J Neurosci. 2006;26:4649-59 pubmed..Together, our data indicate that mutant htt may induce CA150 dysfunction in striatal neurons and suggest that the restoration of nuclear protein cooperativity may be neuroprotective. ..
- Rousselet A. Inhibiting Crm1 causes the formation of excess acentriolar spindle poles containing NuMA and B23, but does not affect centrosome numbers. Biol Cell. 2009;101:679-93 pubmed publisher..B23 and NuMA are present at these poles that ultimately focus around the centrosome. Inhibition of Crm1 at metaphase has no effect on the control of centrosome numbers. ..
- Dahmane N, Charron G, Lopes C, Yaspo M, Maunoury C, Decorte L, et al. Down syndrome-critical region contains a gene homologous to Drosophila sim expressed during rat and human central nervous system development. Proc Natl Acad Sci U S A. 1995;92:9191-5 pubmed..The expression pattern of this gene suggests that it might be involved in the pathogenesis of some of the morphological features and brain anomalies observed in Down syndrome. ..
- Duprez E, Tong J, Derre J, Chen S, Berger R, Chen Z, et al. JEM-1, a novel gene encoding a leucine-zipper nuclear factor upregulated during retinoid-induced maturation of NB4 promyelocytic leukaemia. Oncogene. 1997;14:1563-70 pubmed..We hypothesise that this novel nuclear factor may act as a transcription factor, or a coregulator, involved in either cell growth control and/or maturation. ..
- Sirri V, Roussel P, Hernandez Verdun D. The mitotically phosphorylated form of the transcription termination factor TTF-1 is associated with the repressed rDNA transcription machinery. J Cell Sci. 1999;112 ( Pt 19):3259-68 pubmed..The reorganization of the mitotic rDNA promoter might be induced by phosphorylation of certain components of the rDNA transcription machinery and participate in silencing of rDNA during mitosis...
- Soussi T, Beroud C. Assessing TP53 status in human tumours to evaluate clinical outcome. Nat Rev Cancer. 2001;1:233-40 pubmed..What simple steps can be taken to ensure that patients benefit from our understanding of TP53? ..
- Haumaitre C, Reber M, Cereghini S. Functions of HNF1 family members in differentiation of the visceral endoderm cell lineage. J Biol Chem. 2003;278:40933-42 pubmed..Thus, in this context, HNF1 functionally replaces both vHNF1 isoforms, suggesting that the different developmental functions of these transcription factors are mainly due to the acquisition of novel expression patterns. ..
- Garcia M, Charvin D, Caboche J. Expanded huntingtin activates the c-Jun terminal kinase/c-Jun pathway prior to aggregate formation in striatal neurons in culture. Neuroscience. 2004;127:859-70 pubmed..Thus our data suggest that c-Jun activation and induction, is an early event in the pathogenesis of HD, occurring prior to formation of nuclear aggregates of Exp-Htt. ..
- Madrid R, Gasteier J, Bouchet J, Schröder S, Geyer M, Benichou S, et al. Oligomerization of the diaphanous-related formin FHOD1 requires a coiled-coil motif critical for its cytoskeletal and transcriptional activities. FEBS Lett. 2005;579:441-8 pubmed..Together, these results indicate that oligomerization of FHOD1 via the coiled-coil motif is a critical parameter for its biological activities. ..
- Dentin R, Benhamed F, Pégorier J, Foufelle F, Viollet B, Vaulont S, et al. Polyunsaturated fatty acids suppress glycolytic and lipogenic genes through the inhibition of ChREBP nuclear protein translocation. J Clin Invest. 2005;115:2843-54 pubmed
- Chaabane C, Corvazier E, Bredoux R, Dally S, Raies A, Villemain A, et al. Sarco/endoplasmic reticulum Ca2+ATPase type 3 isoforms (SERCA3b and SERCA3f): distinct roles in cell adhesion and ER stress. Biochem Biophys Res Commun. 2006;345:1377-85 pubmed..This was associated with the activation of caspase cascade and a higher spontaneous cell death. In conclusion, these data point for the first time to distinct physiological roles of SERCA3 isoforms in cell functions. ..
- Legent K, Dutriaux A, Delanoue R, Silber J. Cell cycle genes regulate vestigial and scalloped to ensure normal proliferation in the wing disc of Drosophila melanogaster. Genes Cells. 2006;11:907-18 pubmed..This points to a homeostatic feedback regulation between proliferation regulators and the VG-SD wing selector. ..
- Rougeot J, Renard M, Randsholt N, Peronnet F, Mouchel Vielh E. The elongin complex antagonizes the chromatin factor Corto for vein versus intervein cell identity in Drosophila wings. PLoS ONE. 2013;8:e77592 pubmed publisher..We propose that Corto and the Elongin complex participate together in vein vs intervein fate, possibly through tissue-specific transcriptional regulation of rhomboid. ..
- Santa CecÃlia F, Socias B, Ouidja M, Sepulveda Diaz J, AcuÃ±a L, Silva R, et al. Doxycycline Suppresses Microglial Activation by Inhibiting the p38 MAPK and NF-kB Signaling Pathways. Neurotox Res. 2016;29:447-59 pubmed publisher..These results support the idea that doxycycline may be useful in preventing or slowing the progression of PD and other neurodegenerative diseases that exhibit altered glia function. ..
- Romero F, Germani A, Puvion E, Camonis J, Varin Blank N, Gisselbrecht S, et al. Vav binding to heterogeneous nuclear ribonucleoprotein (hnRNP) C. Evidence for Vav-hnRNP interactions in an RNA-dependent manner. J Biol Chem. 1998;273:5923-31 pubmed..Furthermore, RNA homopolymers differentially alter the binding affinity of Vav to hnRNP C and hnRNP K. We propose that Vav-hnRNP interactions may be established in an RNA-dependent manner. ..
- Billuart P, Bienvenu T, Ronce N, Des Portes V, Vinet M, Zemni R, et al. Oligophrenin-1 encodes a rhoGAP protein involved in X-linked mental retardation. Nature. 1998;392:923-6 pubmed..Such activation is known to affect cell migration and outgrowth of axons and dendrites in vivo. Our results demonstrate an association between cognitive impairment and a defect in a signalling pathway that depends on a Ras-like GTPase. ..
- Van De Bor V, Delanoue R, Cossard R, Silber J. Truncated products of the vestigial proliferation gene induce apoptosis. Cell Death Differ. 1999;6:557-64 pubmed..Our results shed new light on the function of the vg gene, in particular, they suggest that the normal and truncated products affect vg target genes in different ways. ..
- Grosfeld A, Andre J, Hauguel De Mouzon S, Berra E, Pouyssegur J, Guerre Millo M. Hypoxia-inducible factor 1 transactivates the human leptin gene promoter. J Biol Chem. 2002;277:42953-7 pubmed..These data demonstrate that leptin is a new hypoxia-inducible gene, which is stimulated in a placental cell line through HIF-1 interaction with a consensus HRE site located at -116 in the proximal promoter. ..
- Delanoue R, Zider A, Cossard R, Dutriaux A, Silber J. Interaction between apterous and early expression of vestigial in formation of the dorso-ventral compartments in the Drosophila wing disc. Genes Cells. 2002;7:1255-66 pubmed..Normal cell proliferation is necessary for ap expression at the level of the D/V boundary. This would be mediated by vg, which interacts in a dose-dependent way with ap. ..
- Dentin R, Benhamed F, Hainault I, Fauveau V, Foufelle F, Dyck J, et al. Liver-specific inhibition of ChREBP improves hepatic steatosis and insulin resistance in ob/ob mice. Diabetes. 2006;55:2159-70 pubmed..Taken together, our results demonstrate that ChREBP is central for the regulation of lipogenesis in vivo and plays a determinant role in the development of the hepatic steatosis and of insulin resistance in ob/ob mice. ..
- Mochel F, Missirian C, Reynaud R, Moncla A. Normal intelligence and social interactions in a male patient despite the deletion of NLGN4X and the VCX genes. Eur J Med Genet. 2008;51:68-73 pubmed publisher..Therefore, our case argues against a major role of NLGN4X and the VCX genes alone in cognitive development and/or communication processes. ..
- Warcoin M, Lespinasse J, Despouy G, Dubois d Enghien C, Lauge A, Portnoi M, et al. Fertility defects revealing germline biallelic nonsense NBN mutations. Hum Mutat. 2009;30:424-30 pubmed publisher..NBN mutations should thus be considered a new cause of infertility, and should be searched for if associated with the biological abnormalities of NBS. ..
- Borie C, Colas C, Dartigues P, Lazure T, Rince P, Buhard O, et al. The mechanisms underlying MMR deficiency in immunodeficiency-related non-Hodgkin lymphomas are different from those in other sporadic microsatellite instable neoplasms. Int J Cancer. 2009;125:2360-6 pubmed publisher..They give the exact way how to make the diagnosis of MSI in these tumors and may help to define biological and clinicalrisk factors associated with their emergence in such a clinicalcontext. ..
- Schleiermacher G, Mosseri V, London W, Maris J, Brodeur G, Attiyeh E, et al. Segmental chromosomal alterations have prognostic impact in neuroblastoma: a report from the INRG project. Br J Cancer. 2012;107:1418-22 pubmed publisher..A segmental genomic profile, rather than the single genetic markers, adds prognostic information to the clinical markers age and stage in neuroblastoma patients without MNA, underlining the importance of pangenomic studies. ..
- Alexandre M, Rivaud Pechoux S, Challe G, Durr A, Gaymard B. Functional consequences of oculomotor disorders in hereditary cerebellar ataxias. Cerebellum. 2013;12:396-405 pubmed publisher..The discrepancy between objective and subjective measures underlines the largely unconscious aspect of saccade control and leads us to consider the need for an adapted therapy. ..
- Bureau J, Bihl F, Brahic M, Le Paslier D. The gene coding for interferon-gamma is linked to the D12S335 and D12S313 microsatellites and to the MDM2 gene. Genomics. 1995;28:109-12 pubmed..Finally, we describe the organization of the Ifg, Myf-6, Mdm1, and Mdm2 loci on mouse chromosome 10, in a region syntenic to human chromosome band 12q15. ..
- Toure A, Dorseuil O, Morin L, Timmons P, Jegou B, Reibel L, et al. MgcRacGAP, a new human GTPase-activating protein for Rac and Cdc42 similar to Drosophila rotundRacGAP gene product, is expressed in male germ cells. J Biol Chem. 1998;273:6019-23 pubmed..Since rotundRacGAP deletion leads to male sterility in the fruit fly, the mgcRacGAP gene may prove likewise to play a key role in mammalian male fertility. ..
- Prigent Y, Troalen F, Dadoune J. Immunoelectron microscopic visualization of intermediate basic proteins HPI1 and HPI2 in human spermatids and spermatozoa. Reprod Nutr Dev. 1998;38:417-27 pubmed
- Bonne G, Mercuri E, Muchir A, Urtizberea A, Becane H, Recan D, et al. Clinical and molecular genetic spectrum of autosomal dominant Emery-Dreifuss muscular dystrophy due to mutations of the lamin A/C gene. Ann Neurol. 2000;48:170-80 pubmed
- Cote F, Schussler N, Boularand S, Peirotes A, Thévenot E, Mallet J, et al. Involvement of NF-Y and Sp1 in basal and cAMP-stimulated transcriptional activation of the tryptophan hydroxylase (TPH ) gene in the pineal gland. J Neurochem. 2002;81:673-85 pubmed..These factors participate in a novel pathway for the cAMP-mediated response of the TPH promoter, which is independent of the canonical CRE-mediated response. ..
- Rebouissou S, Rosty C, Lecuru F, Boisselier S, Bui H, Le Frere Belfa M, et al. Mutation of TCF1 encoding hepatocyte nuclear factor 1alpha in gynecological cancer. Oncogene. 2004;23:7588-92 pubmed..These results suggest that HNF1alpha may contribute to endometrial carcinogenesis through complete HNF1alpha inactivation like in liver cell adenoma or by haploinsufficiency like in MSI-H colorectal cancer. ..
- Depaux A, Regnier Ricard F, Germani A, Varin Blank N. A crosstalk between hSiah2 and Pias E3-ligases modulates Pias-dependent activation. Oncogene. 2007;26:6665-76 pubmed..This report describes a new interconnection between sumoylation and ubiquitination pathways by regulating the levels of the E3-ligases available for these processes. ..
- Ben Yaou R, Toutain A, Arimura T, Demay L, Massart C, Peccate C, et al. Multitissular involvement in a family with LMNA and EMD mutations: Role of digenic mechanism?. Neurology. 2007;68:1883-94 pubmed..This highlights the crucial role of lamin A/C-emerin interactions, with evidence for synergistic effects of these mutations that lead to Emery-Dreifuss muscular dystrophy as the worsened result of digenic mechanism in this family. ..
- Pérot G, Derré J, Coindre J, Tirode F, Lucchesi C, Mariani O, et al. Strong smooth muscle differentiation is dependent on myocardin gene amplification in most human retroperitoneal leiomyosarcomas. Cancer Res. 2009;69:2269-78 pubmed publisher..These data also provide new insights on the cellular origin of these sarcomas and on the complex connections between oncogenesis and differentiation in mesenchymal tumors. ..
- Szuplewski S, Fraisse Véron I, George H, Terracol R. vrille is required to ensure tracheal integrity in Drosophila embryo. Dev Growth Differ. 2010;52:409-18 pubmed publisher..Most of the defects were observed after stage 14 and affect all branches, resulting in branch breaks, abnormal branching and elongation. ..
- Dubuquoy C, Robichon C, Lasnier F, Langlois C, Dugail I, Foufelle F, et al. Distinct regulation of adiponutrin/PNPLA3 gene expression by the transcription factors ChREBP and SREBP1c in mouse and human hepatocytes. J Hepatol. 2011;55:145-53 pubmed publisher..All together, our results suggest that adiponutrin/PNPLA3 is regulated by two key factors of the glycolytic and lipogenic pathways, raising the question of its implication in the metabolism of carbohydrates and lipids. ..
- Benhamed F, Denechaud P, Lemoine M, Robichon C, Moldes M, Bertrand Michel J, et al. The lipogenic transcription factor ChREBP dissociates hepatic steatosis from insulin resistance in mice and humans. J Clin Invest. 2012;122:2176-94 pubmed publisher..Together, these results demonstrate that increased ChREBP can dissociate hepatic steatosis from insulin resistance, with beneficial effects on both glucose and lipid metabolism. ..
- Gras D, Jonard L, Roze E, Chantot Bastaraud S, Koht J, Motte J, et al. Benign hereditary chorea: phenotype, prognosis, therapeutic outcome and long term follow-up in a large series with new mutations in the TITF1/NKX2-1 gene. J Neurol Neurosurg Psychiatry. 2012;83:956-62 pubmed publisher..The aim of the study was to refine the movement disorders phenotype. We also studied disease course and response to therapy in a large series of genetically proven patients...
- Derossi D, Joliot A, Chassaing G, Prochiantz A. The third helix of the Antennapedia homeodomain translocates through biological membranes. J Biol Chem. 1994;269:10444-50 pubmed..Finally, substitution of two tryptophans by two phenylalanines strongly diminishes translocation, raising the possibility that the internalization of the third helix is not solely based on its general hydrophobicity. ..
- Torchet C, Jacq C, Hermann Le Denmat S. Two mutant forms of the S1/TPR-containing protein Rrp5p affect the 18S rRNA synthesis in Saccharomyces cerevisiae. RNA. 1998;4:1636-52 pubmed..Furthermore, we show that suppression by the Rok1p putative RNA helicase rescues the 18S rRNA synthesis defect caused by the rrp5delta6 mutation. ..
- Launay P, Grossetête B, Arcos Fajardo M, Gaudin E, Torres S, Beaudoin L, et al. Fcalpha receptor (CD89) mediates the development of immunoglobulin A (IgA) nephropathy (Berger's disease). Evidence for pathogenic soluble receptor-Iga complexes in patients and CD89 transgenic mice. J Exp Med. 2000;191:1999-2009 pubmed..Depletion of soluble CD89 from serum abolished this effect. These results reveal the key role of soluble CD89 in the pathogenesis of IgAN and provide an in vivo model that will be useful for developing new treatments. ..
- Drutel G, Kathmann M, Heron A, Gros C, Mace S, Schwartz J, et al. Two splice variants of the hypoxia-inducible factor HIF-1alpha as potential dimerization partners of ARNT2 in neurons. Eur J Neurosci. 2000;12:3701-8 pubmed
- Trueba S, Auge J, Mattei G, Etchevers H, Martinovic J, Czernichow P, et al. PAX8, TITF1, and FOXE1 gene expression patterns during human development: new insights into human thyroid development and thyroid dysgenesis-associated malformations. J Clin Endocrinol Metab. 2005;90:455-62 pubmed..In conclusion, the expression patterns described here show some differences from those reported in the mouse. They explain the malformations associated with TD in patients carrying PAX8, TITF1, and FOXE1 gene mutations. ..
- Coppo P, Clauvel J, Bengoufa D, Fuentes V, Gouilleux Gruart V, Courvalin J, et al. Autoimmune cytopenias associated with autoantibodies to nuclear envelope polypeptides. Am J Hematol. 2004;77:241-9 pubmed..Their detection strongly suggests an autoimmune process. Such cytopenias are often manifestations of a lupus or lupus-like disease and are responsive to steroids. ..
- Revy P, Buck D, Le Deist F, de Villartay J. The repair of DNA damages/modifications during the maturation of the immune system: lessons from human primary immunodeficiency disorders and animal models. Adv Immunol. 2005;87:237-95 pubmed
- Zanni G, Saillour Y, Nagara M, Billuart P, Castelnau L, Moraine C, et al. Oligophrenin 1 mutations frequently cause X-linked mental retardation with cerebellar hypoplasia. Neurology. 2005;65:1364-9 pubmed
- Fasseu M, Aplan P, Chopin M, Boissel N, Bories J, Soulier J, et al. p16INK4A tumor suppressor gene expression and CD3epsilon deficiency but not pre-TCR deficiency inhibit TAL1-linked T-lineage leukemogenesis. Blood. 2007;110:2610-9 pubmed..We also show that the CD3epsilon-mediated signal transduction pathway is essential for this transformation process, since the TAL1xLMO1xCD3epsilon-deficient mice do not develop T-ALL for up to 1 year. ..
- Charvin D, Roze E, Perrin V, Deyts C, Betuing S, Pages C, et al. Haloperidol protects striatal neurons from dysfunction induced by mutated huntingtin in vivo. Neurobiol Dis. 2008;29:22-9 pubmed..These findings indicate that D2 receptors activation contributes to the deleterious effects of expHtt on striatal function and may represent an interesting early target to alter the subsequent course of neuropathology in HD. ..
- Chettouh H, Fartoux L, Aoudjehane L, Wendum D, Clapéron A, Chretien Y, et al. Mitogenic insulin receptor-A is overexpressed in human hepatocellular carcinoma due to EGFR-mediated dysregulation of RNA splicing factors. Cancer Res. 2013;73:3974-86 pubmed publisher..Increased expression of IR-A during neoplastic transformation of hepatocytes could mediate some of the adverse effects of hyperinsulinemia on HCC. ..
- Vallet V, Henrion A, Bucchini D, Casado M, Raymondjean M, Kahn A, et al. Glucose-dependent liver gene expression in upstream stimulatory factor 2 -/- mice. J Biol Chem. 1997;272:21944-9 pubmed..In this paper, we provide the first evidence that USF2 proteins are required in vivo for a normal transcriptional response of L-type pyruvate kinase and Spot 14 genes to glucose in the liver. ..
- Bluteau O, Jeannot E, Bioulac Sage P, Marqués J, Blanc J, Bui H, et al. Bi-allelic inactivation of TCF1 in hepatic adenomas. Nat Genet. 2002;32:312-5 pubmed..These results indicate that inactivation of TCF1, whether sporadic or associated with MODY3, is an important genetic event in the occurrence of human liver adenoma, and may be an early step in the development of some HCCs. ..
- Lefevre J, Colas C, Coulet F, Bonilla C, Mourra N, Flejou J, et al. MYH biallelic mutation can inactivate the two genetic pathways of colorectal cancer by APC or MLH1 transversions. Fam Cancer. 2010;9:589-94 pubmed publisher..588 + 5G > T) leading to a complete deletion of exon 7 at the RNA level. This observation demonstrates that MLH1 can be a target of MYH transversions leading to MSI phenotype...
- Theocharis S, Klijanienko J, Giaginis C, Rodriguez J, Jouffroy T, Girod A, et al. Expression of DNA repair proteins, MSH2, MLH1 and MGMT in mobile tongue squamous cell carcinoma: associations with clinicopathological parameters and patients' survival. J Oral Pathol Med. 2011;40:218-26 pubmed publisher..0451). The present study supported evidence for possible implication of MSH2, MLH1 and MGMT proteins in the formation and progression of mobile tongue SCC. ..
- Geoffroy M, Chelbi Alix M. Role of promyelocytic leukemia protein in host antiviral defense. J Interferon Cytokine Res. 2011;31:145-58 pubmed publisher..This review will focus on the regulation of PML and the implication of PML NBs in conferring resistance to DNA and RNA viruses. The role of PML in mediating an IFN-induced antiviral state will also be discussed. ..
- Soares D, Battistella A, Rocca C, Matuo R, Henriques J, Larsen A, et al. Ataxia telangiectasia mutated- and Rad3-related kinase drives both the early and the late DNA-damage response to the monofunctional antitumour alkylator S23906. Biochem J. 2011;437:63-73 pubmed publisher..These findings identify ATR as a central co-ordinator of the DNA-damage response to S23906, and provide a mechanistic rationale for combinations of S23906 and similar agents with checkpoint abrogators. ..
- Martin N, Benhamed M, Nacerddine K, Demarque M, Van Lohuizen M, Dejean A, et al. Physical and functional interaction between PML and TBX2 in the establishment of cellular senescence. EMBO J. 2012;31:95-109 pubmed publisher..Collectively, our findings indicate that PML and TBX2 act in an autoregulatory loop to control the effective execution of the senescence program. ..
- Rey Campos J, Chouard T, Yaniv M, Cereghini S. vHNF1 is a homeoprotein that activates transcription and forms heterodimers with HNF1. EMBO J. 1991;10:1445-57 pubmed..Our results raise the possibility that heterodimerization between homeoproteins could be a common phenomenon in higher eukaryotes, which may have implications in the regulatory network sustained between these factors. ..
- Muchardt C, Yaniv M. A human homologue of Saccharomyces cerevisiae SNF2/SWI2 and Drosophila brm genes potentiates transcriptional activation by the glucocorticoid receptor. EMBO J. 1993;12:4279-90 pubmed..The co-operation between hbrm and GR required the DNA binding domain of GR and two separated regions of the hbrm protein, including a domain with homology to known helicases. ..
- Muchardt C, Reyes J, Bourachot B, Leguoy E, Yaniv M. The hbrm and BRG-1 proteins, components of the human SNF/SWI complex, are phosphorylated and excluded from the condensed chromosomes during mitosis. EMBO J. 1996;15:3394-402 pubmed..We suggest that chromosomal exclusion of the human SNF/SWI complex at the G2-M transition could be part of the mechanism leading to transcriptional arrest during mitosis. ..
- Escalier D, Allenet B, Badrichani A, Garchon H. High level expression of the Xlr nuclear protein in immature thymocytes and colocalization with the matrix-associated region-binding SATB1 protein. J Immunol. 1999;162:292-8 pubmed
- Savino T, Bastos R, Jansen E, Hernandez Verdun D. The nucleolar antigen Nop52, the human homologue of the yeast ribosomal RNA processing RRP1, is recruited at late stages of nucleologenesis. J Cell Sci. 1999;112 ( Pt 12):1889-900 pubmed..The evolutionary conservation of Nop52 and the lethal effects observed in gene disruption experiments, predict a critical role for Nop52 in the generation of 28S rRNA. ..
- Lavigne M, Eskeland R, Azebi S, Saint André V, Jang S, Batsche E, et al. Interaction of HP1 and Brg1/Brm with the globular domain of histone H3 is required for HP1-mediated repression. PLoS Genet. 2009;5:e1000769 pubmed publisher..Altogether, our data suggest that HP1 chromoshadow-domains can benefit from the opening of nucleosomal structures to bind chromatin and that HP1 proteins use this property to detect and arrest unwanted chromatin remodeling. ..
- Liot G, Zala D, Pla P, Mottet G, Piel M, Saudou F. Mutant Huntingtin alters retrograde transport of TrkB receptors in striatal dendrites. J Neurosci. 2013;33:6298-309 pubmed publisher..This transport alteration may further impair BDNF-TrkB survival signaling within the corticostriatal connection that is most affected in HD...
- Serre V, Rozanska A, Beinat M, Chretien D, Boddaert N, Munnich A, et al. Mutations in mitochondrial ribosomal protein MRPL12 leads to growth retardation, neurological deterioration and mitochondrial translation deficiency. Biochim Biophys Acta. 2013;1832:1304-12 pubmed publisher..Therefore, analysis of the mutated version found in the subject presented here suggests that the mammalian protein does not function in an entirely analogous manner to the eubacterial L7/L12 equivalent. ..
- Joliot A, Pernelle C, Deagostini Bazin H, Prochiantz A. Antennapedia homeobox peptide regulates neural morphogenesis. Proc Natl Acad Sci U S A. 1991;88:1864-8 pubmed
- Catala F, Wanner R, Barton P, Cohen A, Wright W, Buckingham M. A skeletal muscle-specific enhancer regulated by factors binding to E and CArG boxes is present in the promoter of the mouse myosin light-chain 1A gene. Mol Cell Biol. 1995;15:4585-96 pubmed..Mutations within the CArG box distinguish between the binding of this complex and binding of SRF; only SRF binding is directly involved in the specific regulation of the MLC1A gene in skeletal muscle cell lines. ..
- Wang Y, Toury R, Hauchecorne M, Balmain N. Expression and subcellular localization of the Myc superfamily proteins: c-Myc, Max, Mad1 and Mxi1 in the epiphyseal plate cartilage chondrocytes of growing rats. Cell Mol Biol (Noisy-le-grand). 1997;43:175-88 pubmed..The variations in immuno-patterns and intracellular distributions suggest that each protooncogene protein has specific roles in the functional changes in the chondrocytes at each step of their terminal differentiation. ..
- Vialard F, Toyama K, Vernoux S, Carlson E, Epstein C, Sinet P, et al. Overexpression of mSim2 gene in the zona limitans of the diencephalon of segmental trisomy 16 Ts1Cje fetuses, a mouse model for trisomy 21: a novel whole-mount based RNA hybridization study. Brain Res Dev Brain Res. 2000;121:73-8 pubmed
- Moshous D, Pannetier C, Chasseval Rd R, Deist Fl F, Cavazzana Calvo M, Romana S, et al. Partial T and B lymphocyte immunodeficiency and predisposition to lymphoma in patients with hypomorphic mutations in Artemis. J Clin Invest. 2003;111:381-7 pubmed..This syndrome emphasizes the role of Artemis in the NHEJ pathway of DNA repair and suggests that other, yet ill-defined, conditions associating immunodeficiency and lymphoma could be caused by mutations in genes encoding NHEJ factors. ..
- Poinsignon C, Moshous D, Callebaut I, de Chasseval R, Villey I, de Villartay J. The metallo-beta-lactamase/beta-CASP domain of Artemis constitutes the catalytic core for V(D)J recombination. J Exp Med. 2004;199:315-21 pubmed
- Bellanne Chantelot C, Chauveau D, Gautier J, Dubois Laforgue D, Clauin S, Beaufils S, et al. Clinical spectrum associated with hepatocyte nuclear factor-1beta mutations. Ann Intern Med. 2004;140:510-7 pubmed
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