Genomes and Genes
Experts and Doctors on mutation in Gif sur Yvette, Île de France, France
Locale: Gif sur Yvette, Île de France, France
Publications139 found, 100 shown here
- Haudecoeur E, Tanni res M, Cirou A, Raffoux A, Dessaux Y, Faure D. Different regulation and roles of lactonases AiiB and AttM in Agrobacterium tumefaciens C58. Mol Plant Microbe Interact. 2009;22:529-37 pubmed publisher..This work proved that the lactonases AttM and AiiB are regulated by different plant signals and are implicated in different functions in the course of the A. tumefaciens C58-host interaction...
- Zaros C, Briand J, Boulard Y, Labarre Mariotte S, Garcia Lopez M, Thuriaux P, et al. Functional organization of the Rpb5 subunit shared by the three yeast RNA polymerases. Nucleic Acids Res. 2007;35:634-47 pubmed
- Mosrin C, Riva M, Beltrame M, Cassar E, Sentenac A, Thuriaux P. The RPC31 gene of Saccharomyces cerevisiae encodes a subunit of RNA polymerase C (III) with an acidic tail. Mol Cell Biol. 1990;10:4737-43 pubmed..Its reduced rate of tRNA synthesis in vivo relative to 5.8S rRNA supports the hypothesis that the C31 protein is a functional subunit of RNA polymerase C. ..
- Blanchardon E, Grima B, Klarsfeld A, Chelot E, Hardin P, Preat T, et al. Defining the role of Drosophila lateral neurons in the control of circadian rhythms in motor activity and eclosion by targeted genetic ablation and PERIOD protein overexpression. Eur J Neurosci. 2001;13:871-88 pubmed..Expression of TeTxLC in the LNvs does not impair activity rhythms, which indicates that the PDF-expressing neurons do not use synaptobrevin-dependent transmission to control these rhythms. ..
- Figueroa Bossi N, Lemire S, Maloriol D, Balbont n R, Casades s J, Bossi L. Loss of Hfq activates the sigmaE-dependent envelope stress response in Salmonella enterica. Mol Microbiol. 2006;62:838-52 pubmed publisher..A similar mechanism involving additional, still unidentified, sRNAs, might underlie the growth phase-dependent regulation of other OMP mRNAs...
- De Septenville A, Duigou S, Boubakri H, Michel B. Replication fork reversal after replication-transcription collision. PLoS Genet. 2012;8:e1002622 pubmed publisher..Our results suggest that replication fork reversal occurs after replication-transcription head-on collision, and we propose that it promotes the action of the accessory replicative helicases that dislodge the obstacle. ..
- Thomas D, Barbey R, Henry D, Surdin Kerjan Y. Physiological analysis of mutants of Saccharomyces cerevisiae impaired in sulphate assimilation. J Gen Microbiol. 1992;138:2021-8 pubmed..cerevisiae. Thiosulphate is cleaved into sulphite and sulphide prior to utilization by the sulphate assimilation pathway, as the metabolism of one sulphur atom from thiosulphate requires the presence of an active sulphite reductase. ..
- Sirichandra C, Davanture M, Turk B, Zivy M, Valot B, Leung J, et al. The Arabidopsis ABA-activated kinase OST1 phosphorylates the bZIP transcription factor ABF3 and creates a 14-3-3 binding site involved in its turnover. PLoS ONE. 2010;5:e13935 pubmed publisher..In a wider physiological context, we propose that the long term responses to ABA that require sustained gene expression is, in part, mediated by the stabilization of ABFs driven by ABA-activated SnRK2s. ..
- Pradel E, Boquet P. Utilization of exogenous glucose-1-phosphate as a source of carbon or phosphate by Escherichia coli K12: respective roles of acid glucose-1-phosphatase, hexose-phosphate permease, phosphoglucomutase and alkaline phosphatase. Res Microbiol. 1991;142:37-45 pubmed
- Rivosecchi R, Pongs O, Theil T, Mallart A. Implication of frequenin in the facilitation of transmitter release in Drosophila. J Physiol. 1994;474:223-32 pubmed
- Amrani N, Minet M, Wyers F, Dufour M, Aggerbeck L, Lacroute F. PCF11 encodes a third protein component of yeast cleavage and polyadenylation factor I. Mol Cell Biol. 1997;17:1102-9 pubmed..Moreover, fractions obtained by anion-exchange chromatography of extracts from the wild-type strain contain both Pcf11 and Rna15 in the same fractions, as shown by immunoblotting with a Pcf11-specific antibody. ..
- Lenoir G, Jaxel C, Picard M, le Maire M, Champeil P, Falson P. Conformational changes in sarcoplasmic reticulum Ca(2+)-ATPase mutants: effect of mutations either at Ca(2+)-binding site II or at tryptophan 552 in the cytosolic domain. Biochemistry. 2006;45:5261-70 pubmed
- Preat T, Therond P, Lamour Isnard C, Limbourg Bouchon B, Tricoire H, Erk I, et al. A putative serine/threonine protein kinase encoded by the segment-polarity fused gene of Drosophila. Nature. 1990;347:87-9 pubmed..This result provides further insight into segment-polarity interactions and their role in pattern formation. ..
- Le Du M, Lamoure C, Muller B, Bulgakov O, Lajeunesse E, Menez A, et al. Artificial evolution of an enzyme active site: structural studies of three highly active mutants of Escherichia coli alkaline phosphatase. J Mol Biol. 2002;316:941-53 pubmed..This study shows how structural analysis may help to progress in the improvement of an enzyme catalytic activity (k(cat)), and explains the structural events associated with this artificial evolution. ..
- Leroy C, Lee S, Vaze M, Ochsenbein F, Ochsenbien F, Guerois R, et al. PP2C phosphatases Ptc2 and Ptc3 are required for DNA checkpoint inactivation after a double-strand break. Mol Cell. 2003;11:827-35 pubmed..In vivo and in vitro evidence suggests that phosphorylated forms of Ptc2 and Ptc3 specifically bind to the Rad53 FHA1 domain and inactivate Rad53-dependent pathways during adaptation and recovery by dephosphorylating Rad53. ..
- Belin P, Dassa J, Drevet P, Lajeunesse E, Savatier A, Boulain J, et al. Toxicity-based selection of Escherichia coli mutants for functional recombinant protein production: application to an antibody fragment. Protein Eng Des Sel. 2004;17:491-500 pubmed..This is the first report demonstrating the possibility of directly selecting on agar plates E.coli strains improved for functional recombinant protein production from a large bacterial mutant library. ..
- Hlavacek O, Bourens M, Salone V, Lachacinski N, Lemaire C, Dujardin G. The transcriptional activator HAP4 is a high copy suppressor of an oxa1 yeast mutation. Gene. 2005;354:53-7 pubmed..We show that the suppressor gene corresponds to the nuclear transcriptional activator Hap4p which is known to regulate respiratory functions. ..
- Zeeh J, Zeghouf M, Grauffel C, Guibert B, Martin E, Dejaegere A, et al. Dual specificity of the interfacial inhibitor brefeldin a for arf proteins and sec7 domains. J Biol Chem. 2006;281:11805-14 pubmed..Altogether, our results reveal the Tyr/Phe substitution as a novel tool for monitoring BFA sensitivity of cellular ArfGEFs and document the exquisite and dual specificity that can be achieved by an interfacial inhibitor. ..
- Auzat I, Le Bras G, Garel J. Allosteric activation increases the maximum velocity of E. coli phosphofructokinase. J Mol Biol. 1997;267:476-80 pubmed
- Lestini R, Michel B. UvrD controls the access of recombination proteins to blocked replication forks. EMBO J. 2007;26:3804-14 pubmed..UvrD action on RecA is conserved in evolution as it can be performed in E. coli by the UvrD homologue from Bacillus subtilis, PcrA. ..
- Auzat I, Dr ge A, Weise F, Lurz R, Tavares P. Origin and function of the two major tail proteins of bacteriophage SPP1. Mol Microbiol. 2008;70:557-69 pubmed publisher..The carboxyl-terminal extension is an elaboration present in some tailed bacteriophages. Different extensions were found to combine in a mosaic fashion with the MTP essential module in a subset of Siphoviridae genomes...
- McCaffrey M, Johnson J, Goud B, Myers A, Rossier J, Popoff M, et al. The small GTP-binding protein Rho1p is localized on the Golgi apparatus and post-Golgi vesicles in Saccharomyces cerevisiae. J Cell Biol. 1991;115:309-19 pubmed..Thus, in S. cerevisiae Rho1p resides primarily in the Golgi apparatus, and also in vesicles that are likely to be early post-Golgi vesicles. ..
- Touchon M, Arneodo A, d Aubenton Carafa Y, Thermes C. Transcription-coupled and splicing-coupled strand asymmetries in eukaryotic genomes. Nucleic Acids Res. 2004;32:4969-78 pubmed..These results suggest that transcription-coupled asymmetries result from mutation-repair mechanisms that differ between vertebrates and invertebrates. ..
- To A, Valon C, Savino G, Guilleminot J, Devic M, Giraudat J, et al. A network of local and redundant gene regulation governs Arabidopsis seed maturation. Plant Cell. 2006;18:1642-51 pubmed..In addition, it offers a molecular explanation for the puzzling variable features of lec2 mutant embryos. ..
- Bousquet I, Dujardin G, Poyton R, Slonimski P. Two group I mitochondrial introns in the cob-box and coxI genes require the same MRS1/PET157 nuclear gene product for splicing. Curr Genet. 1990;18:117-24 pubmed
- Motorin Y, Bec G, Tewari R, Grosjean H. Transfer RNA recognition by the Escherichia coli delta2-isopentenyl-pyrophosphate:tRNA delta2-isopentenyl transferase: dependence on the anticodon arm structure. RNA. 1997;3:721-33 pubmed..Our data suggest a recognition mode that implies the interaction of IPTT with the strictly conserved A36A37A38 sequence and the other functional groups located in the minor groove of the anticodon stem. ..
- Bucheton A. I transposable elements and I-R hybrid dysgenesis in Drosophila. Trends Genet. 1990;6:16-21 pubmed..The mechanism and control of this process are now being dissected at the molecular level. ..
- Ephritikhine G, Pagant S, Fujioka S, Takatsuto S, Lapous D, Caboche M, et al. The sax1 mutation defines a new locus involved in the brassinosteroid biosynthesis pathway in Arabidopsis thaliana. Plant J. 1999;18:315-20 pubmed..The SAX1 protein is involved in brassinosteroid-dependent growth of seedlings in both light and dark conditions. ..
- Buhot C, Chenal A, Sanson A, Pouvelle Moratille S, Gelb M, Ménez A, et al. Alteration of the tertiary structure of the major bee venom allergen Api m 1 by multiple mutations is concomitant with low IgE reactivity. Protein Sci. 2004;13:2970-8 pubmed..We showed that Api mut-specific T lymphocytes induced in vivo were stimulated in vitro by both proteins. These data provide new insights in the design of hypoallergenic molecules. ..
- Belgacem Y, Martin J. Hmgcr in the corpus allatum controls sexual dimorphism of locomotor activity and body size via the insulin pathway in Drosophila. PLoS ONE. 2007;2:e187 pubmed..These results provide evidence: (i) that HMGCR expression is controlled by the InR and (ii) that InR and HMGCR specifically in the ca, are involved in the control of body size and sexual dimorphism of locomotor activity. ..
- Boulay C, Wilson A, D Haene S, Kirilovsky D. Identification of a protein required for recovery of full antenna capacity in OCP-related photoprotective mechanism in cyanobacteria. Proc Natl Acad Sci U S A. 2010;107:11620-5 pubmed publisher..The discovery of FRP and its characterization are essential elements in the understanding of the OCP-related photoprotective mechanism in cyanobacteria. ..
- Redrejo Rodríguez M, Vigouroux A, Mursalimov A, Grin I, Alili D, Koshenov Z, et al. Structural comparison of AP endonucleases from the exonuclease III family reveals new amino acid residues in human AP endonuclease 1 that are involved in incision of damaged DNA. Biochimie. 2016;128-129:20-33 pubmed publisher..Taken together, these data show that NIR is an evolutionarily conserved function in the Xth family of AP endonucleases. ..
- De Gregorio E, Han S, Lee W, Baek M, Osaki T, Kawabata S, et al. An immune-responsive Serpin regulates the melanization cascade in Drosophila. Dev Cell. 2002;3:581-92 pubmed..Our data demonstrate that Serpin-27A is required to restrict the phenoloxidase activity to the site of injury or infection, preventing the insect from excessive melanization. ..
- Cherest H, Surdin Kerjan Y. Genetic analysis of a new mutation conferring cysteine auxotrophy in Saccharomyces cerevisiae: updating of the sulfur metabolism pathway. Genetics. 1992;130:51-8 pubmed..cerevisiae. The study of the meiotic progeny of diploid strains heterozygous at the STR1 locus has shown that the str1-1 mutation undergoes a particularly high frequency of meiotic gene conversion. ..
- Ephritikhine G, Fellner M, Vannini C, Lapous D, Barbier Brygoo H. The sax1 dwarf mutant of Arabidopsis thaliana shows altered sensitivity of growth responses to abscisic acid, auxin, gibberellins and ethylene and is partially rescued by exogenous brassinosteroid. Plant J. 1999;18:303-14 pubmed..Wild-type sensitivities to ABA, auxin and gibberellins were also restored in sax1 plants by exogenous application of brassinosteroid, illustrating the pivotal importance of the BR-related SAX1 gene. ..
- Eghiaian F, Grosclaude J, Lesceu S, Debey P, Doublet B, Treguer E, et al. Insight into the PrPC-->PrPSc conversion from the structures of antibody-bound ovine prion scrapie-susceptibility variants. Proc Natl Acad Sci U S A. 2004;101:10254-9 pubmed..Additive contributions of these sensitivity-modulating mutations to resistance suggest a possible causal relationship between scrapie resistance and lowered stability of the PrP protein. ..
- Dura J, Randsholt N, Deatrick J, Erk I, Santamaria P, Freeman J, et al. A complex genetic locus, polyhomeotic, is required for segmental specification and epidermal development in D. melanogaster. Cell. 1987;51:829-39 pubmed..We propose a model that may account for this unusual functional organization. ..
- Bernard D, Gabilly S, Dujardin G, Merchant S, Hamel P. Overlapping specificities of the mitochondrial cytochrome c and c1 heme lyases. J Biol Chem. 2003;278:49732-42 pubmed..Based on the functional interaction of Cyc2p with CCHL and the presence of a putative FAD-binding site in the protein, we hypothesize that Cyc2p controls the redox chemistry of the heme lyase reaction. ..
- Klarsfeld A, Malpel S, Michard Vanhée C, Picot M, Chélot E, Rouyer F. Novel features of cryptochrome-mediated photoreception in the brain circadian clock of Drosophila. J Neurosci. 2004;24:1468-77 pubmed
- Guillon B, Bulteau A, Wattenhofer Donzé M, Schmucker S, Friguet B, Puccio H, et al. Frataxin deficiency causes upregulation of mitochondrial Lon and ClpP proteases and severe loss of mitochondrial Fe-S proteins. FEBS J. 2009;276:1036-47 pubmed publisher..The correlative effect of Lon and ClpP upregulation on loss of mitochondrial Fe-S proteins during the progression of the disease may suggest that Fe-S proteins are potential targets of Lon and ClpP proteases in FRDA. ..
- Wolff N, Gilquin B, Courchay K, Callebaut I, Worman H, Zinn Justin S. Structural analysis of emerin, an inner nuclear membrane protein mutated in X-linked Emery-Dreifuss muscular dystrophy. FEBS Lett. 2001;501:171-6 pubmed..The existence of a conserved solvent-exposed surface on the LEM domains of LAP2 and emerin is discussed, as well as the nature of a possible common target. ..
- Cassan N, Lagoutte B, Sétif P. Ferredoxin-NADP+ reductase. Kinetics of electron transfer, transient intermediates, and catalytic activities studied by flash-absorption spectroscopy with isolated photosystem I and ferredoxin. J Biol Chem. 2005;280:25960-72 pubmed..Identical rates were found with photosystem I lacking the PsaE subunit and wild type photosystem I. This suggests that, in contrast with previous proposals, the PsaE subunit is not involved in NADP+ photoreduction. ..
- Bourgeois B, Gilquin B, Tellier Lebegue C, Ostlund C, Wu W, Perez J, et al. Inhibition of TGF-? signaling at the nuclear envelope: characterization of interactions between MAN1, Smad2 and Smad3, and PPM1A. Sci Signal. 2013;6:ra49 pubmed publisher..These results demonstrate a nuclear envelope-localized mechanism of inactivating TGF-? signaling in which MAN1 competes with transcription factors for binding to Smad2 and Smad3 and facilitates their dephosphorylation by PPM1A...
- Maïga A, Merlin J, Marcon E, Rouget C, Larregola M, Gilquin B, et al. Orthosteric binding of ?-Da1a, a natural peptide of snake venom interacting selectively with the ?1A-adrenoceptor. PLoS ONE. 2013;8:e68841 pubmed publisher..39)) and agonist (F288(6.51) and F312(7.39)) ligands. Its selectivity for the ?1A-adrenoceptor may result, at least partly, from its interaction with the residue F86(2.64), which appears to be important also for HEAT binding. ..
- Poulain C, Ferrus A, Mallart A. Modulation of type A K+ current in Drosophila larval muscle by internal Ca2+; effects of the overexpression of frequenin. Pflugers Arch. 1994;427:71-9 pubmed..One possible explanation for the loss of IA modulation in the V7 mutation is that the excess of frequenin alters intracellular cGMP-dependent metabolic pathways responsible for the internal calcium homeostasis. ..
- Peyroche A, Antonny B, Robineau S, Acker J, Cherfils J, Jackson C. Brefeldin A acts to stabilize an abortive ARF-GDP-Sec7 domain protein complex: involvement of specific residues of the Sec7 domain. Mol Cell. 1999;3:275-85 pubmed..We show that the target of BFA inhibition of ARF exchange activity is an ARF-GDP-Sec7 domain protein complex, and that BFA acts to stabilize this complex to a greater extent for a BFA-sensitive Sec7 domain than for a resistant one. ..
- Rouillard J, Brendolise C, Lacroute F. Rna14p, a component of the yeast nuclear cleavage/polyadenylation factor I, is also localised in mitochondria. Mol Gen Genet. 2000;262:1103-12 pubmed..The localisation data strongly suggest that, besides an essential function in mRNA polyadenylation, the Rna14p protein has a non essential function in mitochondrial metabolism. ..
- Dubacq C, Chevalier A, Mann C. The protein kinase Snf1 is required for tolerance to the ribonucleotide reductase inhibitor hydroxyurea. Mol Cell Biol. 2004;24:2560-72 pubmed..Quantitative regulation of Snf1 kinase activity may contribute to the specificity of the effector responses that it controls. ..
- Ballut L, Marchadier B, Baguet A, Tomasetto C, Seraphin B, Le Hir H. The exon junction core complex is locked onto RNA by inhibition of eIF4AIII ATPase activity. Nat Struct Mol Biol. 2005;12:861-9 pubmed..We elucidate the modalities of EJC binding to RNA and provide the first example of how cellular machineries may use RNA helicases to clamp several proteins onto RNA in stable and sequence-independent manners. ..
- Buffin E, Emre D, Karess R. Flies without a spindle checkpoint. Nat Cell Biol. 2007;9:565-72 pubmed
- Gogendeau D, Beisson J, de Loubresse N, Le Caer J, Ruiz F, Cohen J, et al. An Sfi1p-like centrin-binding protein mediates centrin-based Ca2+ -dependent contractility in Paramecium tetraurelia. Eukaryot Cell. 2007;6:1992-2000 pubmed..This study provides the first in vivo demonstration of the role of Sfi1p-like proteins in centrin-mediated Ca2+-dependent contractile processes...
- El Khouri E, Le Pavec G, Toledano M, Delaunay Moisan A. RNF185 is a novel E3 ligase of endoplasmic reticulum-associated degradation (ERAD) that targets cystic fibrosis transmembrane conductance regulator (CFTR). J Biol Chem. 2013;288:31177-91 pubmed publisher..Our data thus identify RNF185 and RNF5 as a novel E3 ligase module that is central to the control of CFTR degradation. ..
- Yang Q, Figueroa Bossi N, Bossi L. Translation enhancing ACA motifs and their silencing by a bacterial small regulatory RNA. PLoS Genet. 2014;10:e1004026 pubmed publisher..Altogether, these data identify the ACA motif as a translation-enhancing module and show that GcvB's ability to antagonize the enhancer function in target mRNAs is quintessential to the regulatory effectiveness of this sRNA. ..
- Belin P, Quemeneur E, Boquet P. A pleîotropic acid phosphatase-deficient mutant of Escherichia coli shows premature termination in the dsbA gene. Use of dsbA::phoA fusions to localize a structurally important domain in DsbA. Mol Gen Genet. 1994;242:23-32 pubmed..The presence is discussed of a structural domain lying around amino acid 170 of DsbA and which is probably essential for its folding into a proteolytic-resistant and enzymatically active form. ..
- Zarzov P, Boucherie H, Mann C. A yeast heat shock transcription factor (Hsf1) mutant is defective in both Hsc82/Hsp82 synthesis and spindle pole body duplication. J Cell Sci. 1997;110 ( Pt 16):1879-91 pubmed..These results show that Hsf1 is required for spindle pole body duplication at 37 degrees C. ..
- Cardazzo B, Hamel P, Sakamoto W, Wintz H, Dujardin G. Isolation of an Arabidopsis thaliana cDNA by complementation of a yeast abc1 deletion mutant deficient in complex III respiratory activity. Gene. 1998;221:117-25 pubmed..thaliana. Phylogenetic analysis revealed that the Abc1At protein belongs to a large family of proteins composed of two eukaryotic and one prokaryotic subgroups differing by their degree of similarity and probably by their function. ..
- Auzat I, Chapuy Regaud S, Le Bras G, Dos Santos D, Ogunniyi A, Le Thomas I, et al. The NADH oxidase of Streptococcus pneumoniae: its involvement in competence and virulence. Mol Microbiol. 1999;34:1018-28 pubmed..This work establishes, for the first time, the role of O2 in the regulation of pneumococcal transformability and virulence. ..
- Expert Bezançon A, Sureau A, Durosay P, Salesse R, Groeneveld H, Lecaer J, et al. hnRNP A1 and the SR proteins ASF/SF2 and SC35 have antagonistic functions in splicing of beta-tropomyosin exon 6B. J Biol Chem. 2004;279:38249-59 pubmed..These data indicate that the G-rich sequence is a composite element that acts as an enhancer or as a silencer, depending on which proteins bind to them. ..
- Silvain M, Bligny D, Aparicio T, Laforet P, Grodet A, Peretti N, et al. Anderson's disease (chylomicron retention disease): a new mutation in the SARA2 gene associated with muscular and cardiac abnormalities. Clin Genet. 2008;74:546-52 pubmed publisher..These results suggest that myolysis and other extraintestinal abnormalities can occur in AD/CMRD and that the clinical evaluation of patients should reflect this. ..
- Hua Van A, Capy P. Analysis of the DDE motif in the Mutator superfamily. J Mol Evol. 2008;67:670-81 pubmed publisher..The characteristics of this motif are depicted in each known family of MULEs. Different hypotheses about the evolution of this triad are discussed. ..
- Hinaux H, Poulain J, Da Silva C, Noirot C, Jeffery W, Casane D, et al. De novo sequencing of Astyanax mexicanus surface fish and Pachón cavefish transcriptomes reveals enrichment of mutations in cavefish putative eye genes. PLoS ONE. 2013;8:e53553 pubmed publisher..Based on these sequence differences, we provide a list of 11 genes that are potential candidates for having a role in cavefish visual system degeneration...
- Dalia T, Yoon S, Galli E, Barre F, Waters C, Dalia A. Enhancing multiplex genome editing by natural transformation (MuGENT) via inactivation of ssDNA exonucleases. Nucleic Acids Res. 2017;45:7527-7537 pubmed publisher..Thus, rational removal of ssDNA exonucleases may be broadly applicable for enhancing the efficacy and ease of MuGENT in diverse naturally transformable species. ..
- Ruiz F, Dupuis Williams P, Klotz C, Forquignon F, Bergdoll M, Beisson J, et al. Genetic evidence for interaction between eta- and beta-tubulins. Eukaryot Cell. 2004;3:212-20 pubmed..The likely function of eta-tubulin as part of a complex specifically involved in basal body biogenesis is discussed. ..
- Bourens M, Panozzo C, Nowacka A, Imbeaud S, Mucchielli M, Herbert C. Mutations in the Saccharomyces cerevisiae kinase Cbk1p lead to a fertility defect that can be suppressed by the absence of Brr1p or Mpt5p (Puf5p), proteins involved in RNA metabolism. Genetics. 2009;183:161-73 pubmed publisher..Our experiments reveal a multilayered system controlling aspects of cell separation, cell integrity, mating, and polarized growth. ..
- Polsinelli I, Nencetti S, Shepard W, Ciccone L, Orlandini E, Stura E. A new crystal form of human transthyretin obtained with a curcumin derived ligand. J Struct Biol. 2016;194:8-17 pubmed publisher..The ligand used to obtain this new polymorph, 4-hydroxychalcone, is related to curcumin. Here we evaluate this crystal form to understand the contribution it may bring to the study of TTR ligands complexes, which are often asymmetric. ..
- Rousselet G, Simon M, Ripoche P, Buhler J. A second nitrogen permease regulator in Saccharomyces cerevisiae. FEBS Lett. 1995;359:215-9 pubmed..Our data suggest that this protein is a post-transcriptional regulator of nitrogen permeases. ..
- Basto R, Gomes R, Karess R. Rough deal and Zw10 are required for the metaphase checkpoint in Drosophila. Nat Cell Biol. 2000;2:939-43 pubmed..These are the first checkpoint components to be identified that do not have obvious homologues in budding yeast. ..
- Merlot S, Gosti F, Guerrier D, Vavasseur A, Giraudat J. The ABI1 and ABI2 protein phosphatases 2C act in a negative feedback regulatory loop of the abscisic acid signalling pathway. Plant J. 2001;25:295-303 pubmed..These results suggest that ABI1 and ABI2 act in a negative feedback regulatory loop of the ABA signalling pathway. ..
- Merlot S, Mustilli A, Genty B, North H, Lefebvre V, Sotta B, et al. Use of infrared thermal imaging to isolate Arabidopsis mutants defective in stomatal regulation. Plant J. 2002;30:601-9 pubmed..Remarkably, ost1 and ost2 represent, to our knowledge, the first Arabidopsis mutations altering ABA responsiveness in stomata and not in seeds. ..
- Tabares L, Cortez N, Hiraoka B, Yamakura F, Un S. Effects of substrate analogues and pH on manganese superoxide dismutases. Biochemistry. 2006;45:1919-29 pubmed..coli and the Gly155Thr mutant of the cambialistic SOD from Porphyromonas gingivalis. A model for anion binding and the observed pK involving tyrosine-34 is presented. ..
- Lebreton S, Martin J. Mutations affecting the cAMP transduction pathway disrupt the centrophobism behavior. J Neurogenet. 2009;23:225-34 pubmed publisher..Remarkably, those flies are perfectly randomly distributed in the arena, suggesting that C316 flies carry an important mutated-gene implicated in neuronal networks required for proper spatial orientation. ..
- Mouna L, Hernandez E, Bonte D, Brost R, Amazit L, Delgui L, et al. Analysis of the role of autophagy inhibition by two complementary human cytomegalovirus BECN1/Beclin 1-binding proteins. Autophagy. 2016;12:327-42 pubmed publisher..Conversely, inhibiting autophagy decreased HCMV infection. Thus, our results demonstrate a new proviral role of autophagy for a DNA virus. ..
- Thierion E, Le Men J, Collombet S, Hernandez C, Coulpier F, Torbey P, et al. Krox20 hindbrain regulation incorporates multiple modes of cooperation between cis-acting elements. PLoS Genet. 2017;13:e1006903 pubmed publisher..This work uncovers a novel, asymmetrical, long-range mode of cooperation between cis-acting elements that might be essential to avoid promiscuous activation of positive autoregulatory elements. ..
- Prud homme N, Gans M, Masson M, Terzian C, Bucheton A. Flamenco, a gene controlling the gypsy retrovirus of Drosophila melanogaster. Genetics. 1995;139:697-711 pubmed..It is located at position 65.9 (20A1-3) on the X chromosome. The mutant allele present in MG strains is essentially recessive. Flamenco seems to control the infective properties of gypsy. ..
- Blaiseau P, Thomas D. Multiple transcriptional activation complexes tether the yeast activator Met4 to DNA. EMBO J. 1998;17:6327-36 pubmed..In addition the sulfur system exacerbates the structural variety of the nucleoprotein complexes in which a single bZIP factor can be engaged. ..
- Zaros C, Thuriaux P. Rpc25, a conserved RNA polymerase III subunit, is critical for transcription initiation. Mol Microbiol. 2005;55:104-14 pubmed..These data indicate that Rpc25 is needed for transcription initiation but is not critical for the elongating properties of RNA polymerase III. ..
- Liehl P, Blight M, Vodovar N, Boccard F, Lemaitre B. Prevalence of local immune response against oral infection in a Drosophila/Pseudomonas infection model. PLoS Pathog. 2006;2:e56 pubmed
- Thiebaut M, Kisseleva Romanova E, Rougemaille M, Boulay J, Libri D. Transcription termination and nuclear degradation of cryptic unstable transcripts: a role for the nrd1-nab3 pathway in genome surveillance. Mol Cell. 2006;23:853-64 pubmed..Our results suggest an important role for the Nrd1p-Nab3p pathway in the control of gene expression throughout the genome. ..
- Chevin L, Billiard S, Hospital F. Hitchhiking both ways: effect of two interfering selective sweeps on linked neutral variation. Genetics. 2008;180:301-16 pubmed publisher..In situations where positive selection is suspected a priori at several closely linked loci, the polymorphism pattern in the region may also be informative about their selective histories. ..
- Monachello D, Allot M, Oliva S, Krapp A, Daniel Vedele F, Barbier Brygoo H, et al. Two anion transporters AtClCa and AtClCe fulfil interconnecting but not redundant roles in nitrate assimilation pathways. New Phytol. 2009;183:88-94 pubmed publisher..The contribution to nitrate homeostasis at the cellular level of members of these different families is discussed. ..
- Cusumano P, Klarsfeld A, Chélot E, Picot M, Richier B, Rouyer F. PDF-modulated visual inputs and cryptochrome define diurnal behavior in Drosophila. Nat Neurosci. 2009;12:1431-7 pubmed publisher..The LN-EO thus integrates light inputs and PDF signaling to control Drosophila diurnal behavior, revealing a new clock-independent function for PDF. ..
- Mondy S, Lenglet A, Cosson V, Pelletier S, Pateyron S, Gilard F, et al. GOLLUM [FeFe]-hydrogenase-like proteins are essential for plant development in normoxic conditions and modulate energy metabolism. Plant Cell Environ. 2014;37:54-69 pubmed publisher..In conclusion, [FeFe]-hydrogenase-like proteins play a central role in eukaryotes including the adaptation of plants to the ambient O2 partial pressure. ..
- Harris D, Tal O, Jallet D, Wilson A, Kirilovsky D, Adir N. Orange carotenoid protein burrows into the phycobilisome to provide photoprotection. Proc Natl Acad Sci U S A. 2016;113:E1655-62 pubmed publisher..Penetration of the N-terminal domain can bring the OCP carotenoid to within 5-10 Ã… of core chromophores; however, alteration of the core structure may be the actual source of energy dissipation. ..
- Braun D, Rao J, Mollet G, Schapiro D, Daugeron M, Tan W, et al. Mutations in KEOPS-complex genes cause nephrotic syndrome with primary microcephaly. Nat Genet. 2017;49:1529-1538 pubmed publisher..We thus identified four new monogenic causes of GAMOS, describe a link between KEOPS function and human disease, and delineate potential pathogenic mechanisms. ..
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