Genomes and Genes
Experts and Doctors on homeostasis in Paris, Île de France, France
Locale: Paris, Île de France, France
- Noble F, Roques B. The role of CCK2 receptors in the homeostasis of the opioid system. Drugs Today (Barc). 2003;39:897-908 pubmed..In this article, we review the experimental pharmacology of the association of CCK2 antagonists and opioids (exogenous and endogenous), emphasizing the clinical interest of such an association. ..
- Expert D, Enard C, Masclaux C. The role of iron in plant host-pathogen interactions. Trends Microbiol. 1996;4:232-7 pubmed..These studies could lead to the development of new control strategies against microbial infections of plants. ..
- Sims N, Clement Lacroix P, Da Ponte F, Bouali Y, Binart N, Moriggl R, et al. Bone homeostasis in growth hormone receptor-null mice is restored by IGF-I but independent of Stat5. J Clin Invest. 2000;106:1095-103 pubmed..Whereas bone length was reduced in Stat5ab(-/-) mice, there was no reduction in trabecular bone remodeling or growth-plate width as observed in GHR(-/-) mice, indicating that the effects of GH in bone may not involve Stat5 activation. ..
- Ermonval M, Baudry A, Baychelier F, Pradines E, Pietri M, Oda K, et al. The cellular prion protein interacts with the tissue non-specific alkaline phosphatase in membrane microdomains of bioaminergic neuronal cells. PLoS ONE. 2009;4:e6497 pubmed publisher..The partnership between TNAP and PrP(C) in neuronal cells may provide new clues as to the neurospecificity of PrP(C) function. ..
- Svensson K, Long J, Jedrychowski M, Cohen P, Lo J, Serag S, et al. A Secreted Slit2 Fragment Regulates Adipose Tissue Thermogenesis and Metabolic Function. Cell Metab. 2016;23:454-66 pubmed publisher..Our findings establish a previously unknown peripheral role for Slit2 as a beige fat secreted factor that has therapeutic potential for the treatment of obesity and related metabolic disorders. ..
- Rigaud S, Fondaneche M, Lambert N, Pasquier B, Mateo V, Soulas P, et al. XIAP deficiency in humans causes an X-linked lymphoproliferative syndrome. Nature. 2006;444:110-4 pubmed..Furthermore, by identifying an XLP immunodeficiency that is caused by mutations in XIAP, we show that XIAP is a potent regulator of lymphocyte homeostasis in vivo. ..
- Rousseau E, Michel P, Hirsch E. The iron-binding protein lactoferrin protects vulnerable dopamine neurons from degeneration by preserving mitochondrial calcium homeostasis. Mol Pharmacol. 2013;84:888-98 pubmed publisher..Overall, our data suggest that the accumulation of lactoferrin in PD brains might be evidence of an attempt by the brain to minimize the consequences of neurodegeneration. ..
- Vidal C, Herzog C, Haeberle A, Bombarde C, Miquel M, Carimalo J, et al. Early dysfunction of central 5-HT system in a murine model of bovine spongiform encephalopathy. Neuroscience. 2009;160:731-43 pubmed publisher..A similar process may occur in the human variant Creutzfeldt-Jacob disease, as suggested by the early symptoms of alterations in mood, sleep and pain sensitivity. ..
- Miermont A, Waharte F, Hu S, McClean M, Bottani S, Leon S, et al. Severe osmotic compression triggers a slowdown of intracellular signaling, which can be explained by molecular crowding. Proc Natl Acad Sci U S A. 2013;110:5725-30 pubmed publisher..Our results shed light on the physical mechanisms that force cells to cope with volume fluctuations to maintain an optimal protein density compatible with cellular functions. ..
- Autran B, Carcelain G, Li T, Blanc C, Mathez D, Tubiana R, et al. Positive effects of combined antiretroviral therapy on CD4+ T cell homeostasis and function in advanced HIV disease. Science. 1997;277:112-6 pubmed..Thus, decreasing the HIV load can reverse HIV-driven activation and CD4(+) T cell defects in advanced HIV-infected patients. ..
- Vialou V, Balasse L, Callebert J, Launay J, Giros B, Gautron S. Altered aminergic neurotransmission in the brain of organic cation transporter 3-deficient mice. J Neurochem. 2008;106:1471-82 pubmed publisher..Altogether our data support a role of OCT3 in the homeostatic regulation of aminergic neurotransmission in the brain. ..
- Meinzer U, Esmiol Welterlin S, Barreau F, Berrebi D, Dussaillant M, Bonacorsi S, et al. Nod2 mediates susceptibility to Yersinia pseudotuberculosis in mice. PLoS ONE. 2008;3:e2769 pubmed publisher..This resistance phenotype was lost in case of intraperitoneal infection. We concluded that Nod2 contributes to the susceptibility to Y. pseudotuberculosis in mice. ..
- Servet C, Ghelis T, Richard L, Zilberstein A, Savoure A. Proline dehydrogenase: a key enzyme in controlling cellular homeostasis. Front Biosci (Landmark Ed). 2012;17:607-20 pubmed
- Bienvenu G, Seurin D, Le Bouc Y, Even P, Babajko S, Magnan C. Dysregulation of energy homeostasis in mice overexpressing insulin-like growth factor-binding protein 6 in the brain. Diabetologia. 2005;48:1189-97 pubmed..These transgenic h-IGFBP-6 mice may be considered a new tool for studies of the involvement of the brain IGF system in metabolism control and obesity. ..
- Eberl G. A new vision of immunity: homeostasis of the superorganism. Mucosal Immunol. 2010;3:450-60 pubmed publisher..Together, we compose a superorganism that is capable of optimal living. In that context, the immune system is not a killer, but rather a force that shapes homeostasis within the superorganism. ..
- Moinard C, Gupta S, Besson V, Morio B, Marchand Leroux C, Chaumeil J, et al. Evidence for impairment of hepatic energy homeostasis in head-injured rat. J Neurotrauma. 2008;25:124-9 pubmed publisher..These findings demonstrate that TBI is responsible for an impairment of liver energy homeostasis. Moreover, these alterations are related neither to anorexia nor to decreased mitochondrial oxidative capacity. ..
- Garabedian M. Regulation of phosphate homeostasis in infants, children, and adolescents, and the role of phosphatonins in this process. Curr Opin Pediatr. 2007;19:488-91 pubmed..From a clinical point of view, these findings offer new tools for the diagnosis of hypophosphatemic rickets (biologic, genetic, imaging techniques) and open the way to new treatment strategies. ..
- Stolarczyk E, Le Gall M, Even P, Houllier A, Serradas P, Brot Laroche E, et al. Loss of sugar detection by GLUT2 affects glucose homeostasis in mice. PLoS ONE. 2007;2:e1288 pubmed..Molecular invalidation of sugar sensing in GLUT2-loop transgenic mice changed multiple aspects of glucose homeostasis, highlighting by a top-down approach, the role of membrane glucose receptors as potential therapeutic targets. ..
- Orth G. Host defenses against human papillomaviruses: lessons from epidermodysplasia verruciformis. Curr Top Microbiol Immunol. 2008;321:59-83 pubmed..An important issue is to establish which cellular genes involved in intrinsic and innate antiviral responses play a part in the outcome of infections with other HPV types, such as genital oncogenic HPVs...
- Gautier E, Huby T, Saint Charles F, Ouzilleau B, Pirault J, Deswaerte V, et al. Conventional dendritic cells at the crossroads between immunity and cholesterol homeostasis in atherosclerosis. Circulation. 2009;119:2367-75 pubmed publisher..Considered together, the present data reveal that conventional DCs are central to the atherosclerotic process, because they are directly implicated in both cholesterol homeostasis and the immune response. ..
- De Saint Basile G, Fischer A. Defective cytotoxic granule-mediated cell death pathway impairs T lymphocyte homeostasis. Curr Opin Rheumatol. 2003;15:436-45 pubmed..These disorders highlight the determinant role of this lytic pathway in the control of lymphocyte expansion and homeostasis. New effectors of this secretory pathway have been thus identified. ..
- Benahmed M, Meresse B, Arnulf B, Barbe U, Mention J, Verkarre V, et al. Inhibition of TGF-beta signaling by IL-15: a new role for IL-15 in the loss of immune homeostasis in celiac disease. Gastroenterology. 2007;132:994-1008 pubmed
- Legent K, Dutriaux A, Delanoue R, Silber J. Cell cycle genes regulate vestigial and scalloped to ensure normal proliferation in the wing disc of Drosophila melanogaster. Genes Cells. 2006;11:907-18 pubmed..This points to a homeostatic feedback regulation between proliferation regulators and the VG-SD wing selector. ..
- Sassi Y, Abi Gerges A, Fauconnier J, Mougenot N, Reiken S, Haghighi K, et al. Regulation of cAMP homeostasis by the efflux protein MRP4 in cardiac myocytes. FASEB J. 2012;26:1009-17 pubmed publisher..These findings suggest that cAMP extrusion via MRP4 acts together with phosphodiesterases to control cAMP levels in cardiac myocytes. ..
- Lacombe P, Oligo C, Domenga V, Tournier Lasserve E, Joutel A. Impaired cerebral vasoreactivity in a transgenic mouse model of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy arteriopathy. Stroke. 2005;36:1053-8 pubmed..Our findings indicate that vascular dysfunction is an early pathogenic event that may promote the subsequent development of brain ischemia in CADASIL. ..
- Bourachot B, Yaniv M, Muchardt C. Growth inhibition by the mammalian SWI-SNF subunit Brm is regulated by acetylation. EMBO J. 2003;22:6505-15 pubmed..Removal of the HDAC inhibitors from the growth medium of these clones leads to downregulation of cyclin D1. This downregulation is absent in cell transformed by oncogenic ras. ..
- Brunel C, Romby P, Sacerdot C, de Smit M, Graffe M, Dondon J, et al. Stabilised secondary structure at a ribosomal binding site enhances translational repression in E. coli. J Mol Biol. 1995;253:277-90 pubmed..This molecular amplification device might be an essential component of translational control considering the low free repressor/ribosome ratio of the low affinity of translational repressors for their target operators. ..
- Joutel A, Monet Leprêtre M, Gosele C, Baron Menguy C, Hammes A, Schmidt S, et al. Cerebrovascular dysfunction and microcirculation rarefaction precede white matter lesions in a mouse genetic model of cerebral ischemic small vessel disease. J Clin Invest. 2010;120:433-45 pubmed publisher..These studies provide in vivo evidence for cerebrovascular dysfunction and microcirculatory failure as key contributors to hypoperfusion and white matter damage in this genetic model of ischemic SVD...
- Larrede S, Quinn C, Jessup W, Frisdal E, Olivier M, Hsieh V, et al. Stimulation of cholesterol efflux by LXR agonists in cholesterol-loaded human macrophages is ABCA1-dependent but ABCG1-independent. Arterioscler Thromb Vasc Biol. 2009;29:1930-6 pubmed publisher..We evaluated the relative contribution of the ABCA1 and ABCG1 transporters to cholesterol efflux from human macrophages, and of the capacity of LXR agonists to reduce foam cell formation by stimulating export of cellular cholesterol...
- Ghazarian L, Simoni Y, Pingris K, Beaudoin L, Lehuen A. [Regulatory role of NKT cells in the prevention of type 1 diabetes]. Med Sci (Paris). 2013;29:722-8 pubmed publisher..These results strengthen the potential role of NKT cells as a key target for the development of therapeutic strategies against type 1 diabetes. ..
- Llorens Cortes C, Beaudet A. [Apelin, a neuropeptide that counteracts vasopressin secretion]. Med Sci (Paris). 2005;21:741-6 pubmed..The development of non peptidic analogs of apelin may therefore offer new therapeutic avenues for the treatment of cardiovascular disorders. ..
- Almeida A, Zaragoza B, Freitas A. Indexation as a novel mechanism of lymphocyte homeostasis: the number of CD4+CD25+ regulatory T cells is indexed to the number of IL-2-producing cells. J Immunol. 2006;177:192-200 pubmed..The present study highlights that maintenance of proportions between different lymphocyte subsets may also be critical for the immune system and are under strict homeostatic control. ..
- Quentin F, Chambrey R, Trinh Trang Tan M, Fysekidis M, Cambillau M, Paillard M, et al. The Cl-/HCO3- exchanger pendrin in the rat kidney is regulated in response to chronic alterations in chloride balance. Am J Physiol Renal Physiol. 2004;287:F1179-88 pubmed..Conversely, NaCl depletion induced by furosemide was associated with increased Pds expression. We conclude that Pds expression is specifically regulated in response to changes in chloride balance...
- Rieck B, Degiacomi G, Zimmermann M, Cascioferro A, Boldrin F, Lazar Adler N, et al. PknG senses amino acid availability to control metabolism and virulence of Mycobacterium tuberculosis. PLoS Pathog. 2017;13:e1006399 pubmed publisher..This function in amino acid homeostasis is conserved amongst the Actinobacteria and provides an example of the close relationship between metabolism and virulence. ..
- Falord M, Mäder U, Hiron A, Debarbouille M, Msadek T. Investigation of the Staphylococcus aureus GraSR regulon reveals novel links to virulence, stress response and cell wall signal transduction pathways. PLoS ONE. 2011;6:e21323 pubmed publisher..This is the first report showing a role for the GraSR TCS in high temperature and oxidative stress survival and linking this system to stress response, cell wall and pathogenesis control pathways. ..
- García Cáceres C, Quarta C, Varela L, Gao Y, Gruber T, Legutko B, et al. Astrocytic Insulin Signaling Couples Brain Glucose Uptake with Nutrient Availability. Cell. 2016;166:867-880 pubmed publisher..We conclude that insulin signaling in hypothalamic astrocytes co-controls CNS glucose sensing and systemic glucose metabolism via regulation of glucose uptake across the BBB. ..
- Mourikis P, Tajbakhsh S. Distinct contextual roles for Notch signalling in skeletal muscle stem cells. BMC Dev Biol. 2014;14:2 pubmed publisher..This review will provide an overview of Notch signalling during myogenic development and postnatally, and underscore the seemingly opposing contextual activities of Notch that have lead to a reassessment of its role in myogenesis. ..
- Barbet G, Demion M, Moura I, Serafini N, Léger T, Vrtovsnik F, et al. The calcium-activated nonselective cation channel TRPM4 is essential for the migration but not the maturation of dendritic cells. Nat Immunol. 2008;9:1148-56 pubmed publisher..Our results establish TRPM4-regulated Ca(2+) homeostasis as crucial for DC mobility but not maturation and emphasize that DC maturation and migration are independently regulated. ..
- Almeida A, Legrand N, Papiernik M, Freitas A. Homeostasis of peripheral CD4+ T cells: IL-2R alpha and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers. J Immunol. 2002;169:4850-60 pubmed
- Monet Leprêtre M, Haddad I, Baron Menguy C, Fouillot Panchal M, Riani M, Domenga Denier V, et al. Abnormal recruitment of extracellular matrix proteins by excess Notch3 ECD: a new pathomechanism in CADASIL. Brain. 2013;136:1830-45 pubmed publisher..Specifically, our results suggest a dysregulation of TIMP3 activity, which could contribute to mutant Notch3(ECD) toxicity by impairing extracellular matrix homeostasis in small vessels. ..
- Vallet M, Picard N, Loffing Cueni D, Fysekidis M, Bloch Faure M, Deschenes G, et al. Pendrin regulation in mouse kidney primarily is chloride-dependent. J Am Soc Nephrol. 2006;17:2153-63 pubmed..These results suggest that factors that are associated with changes in distal chloride delivery govern pendrin expression in the connecting tubule and cortical collecting duct. ..
- Toro R, Konyukh M, Delorme R, Leblond C, Chaste P, Fauchereau F, et al. Key role for gene dosage and synaptic homeostasis in autism spectrum disorders. Trends Genet. 2010;26:363-72 pubmed publisher..Understanding the mechanisms that regulate synaptic homeostasis should shed new light on the causes of ASD and could provide a means to modulate the severity of the symptoms. ..
- Couesnon A, Offner N, Bernard V, Chaverot N, Backer S, Dimitrov A, et al. CLIPR-59: a protein essential for neuromuscular junction stability during mouse late embryonic development. Development. 2013;140:1583-93 pubmed publisher..Thus, CLIPR-59 is involved in the stabilization of specific motor axons at the NMJ during mouse late embryogenesis and its role is crucial for mouse perinatal development. ..
- Hill G, Heudes D, Jacquot C, Gauthier E, Bariety J. Morphometric evidence for impairment of renal autoregulation in advanced essential hypertension. Kidney Int. 2006;69:823-31 pubmed
- Debray D, Rainteau D, Barbu V, Rouahi M, El Mourabit H, Lerondel S, et al. Defects in gallbladder emptying and bile Acid homeostasis in mice with cystic fibrosis transmembrane conductance regulator deficiencies. Gastroenterology. 2012;142:1581-91.e6 pubmed publisher..Patients with cystic fibrosis (CF) have poorly defined defects in biliary function. We evaluated the effects of cystic fibrosis transmembrane conductance regulator (CFTR) deficiency on the enterohepatic disposition of bile acids (BAs)...
- Sakar Y, Nazaret C, Letteron P, Ait Omar A, Avenati M, Viollet B, et al. Positive regulatory control loop between gut leptin and intestinal GLUT2/GLUT5 transporters links to hepatic metabolic functions in rodents. PLoS ONE. 2009;4:e7935 pubmed publisher..This loop appears to be a new mechanism (possibly pathogenic) by which fructose consumption rapidly becomes highly lipogenic and deleterious. ..
- Ferre P, Foufelle F. SREBP-1c transcription factor and lipid homeostasis: clinical perspective. Horm Res. 2007;68:72-82 pubmed
- Arbogast S, Beuvin M, Fraysse B, Zhou H, Muntoni F, Ferreiro A. Oxidative stress in SEPN1-related myopathy: from pathophysiology to treatment. Ann Neurol. 2009;65:677-86 pubmed publisher..These findings pave the way to SEPN1-RM treatment, which would represent a first specific pharmacological treatment for a congenital myopathy. ..
- Theret M, Gsaier L, Schaffer B, Juban G, Ben Larbi S, Weiss Gayet M, et al. AMPKα1-LDH pathway regulates muscle stem cell self-renewal by controlling metabolic homeostasis. EMBO J. 2017;36:1946-1962 pubmed publisher..Finally, providing specific nutrients (galactose/glucose) to MuSCs directly controlled their fate through the AMPKα1/LDH pathway, emphasizing the importance of metabolism in stem cell fate. ..
- ..This review looks at newer data on this topic...
- Raoul W, Poupel L, Tregouet D, Lavalette S, Camelo S, Keller N, et al. MFGE8 does not influence chorio-retinal homeostasis or choroidal neovascularization in vivo. PLoS ONE. 2012;7:e33244 pubmed publisher..Despite a reproducible minor increase of rs1878326 in AMD patients and a very modest increase in BM in Mfge8(-/-) mice, our data suggests that MFGE8 dysfunction does not play a critical role in the pathogenesis of AMD. ..
- Prie D, Beck L, Friedlander G, Silve C. Sodium-phosphate cotransporters, nephrolithiasis and bone demineralization. Curr Opin Nephrol Hypertens. 2004;13:675-81 pubmed..We discuss how recent findings obtained in disorders of phosphate metabolism in humans and in animal models have provided insights into the pathogenesis of renal stone formation and bone demineralization...
- Rouzier C, Moore D, Delorme C, Lacas Gervais S, Ait El Mkadem S, Fragaki K, et al. A novel CISD2 mutation associated with a classical Wolfram syndrome phenotype alters Ca2+ homeostasis and ER-mitochondria interactions. Hum Mol Genet. 2017;26:1599-1611 pubmed publisher..Our results provide important novel insight into the potential disease mechanisms underlying the neurodegenerative consequences of CISD2 mutations and the subsequent development of multisystemic disease. ..
- Prie D, Beck L, Urena P, Friedlander G. Recent findings in phosphate homeostasis. Curr Opin Nephrol Hypertens. 2005;14:318-24 pubmed..We summarize the most recent findings on the proteins that interact with sodium/inorganic phosphate (Na/Pi) cotransporters, the factors that regulate Pi homeostasis and their role in pathology...
- Ferre P, Foufelle F. Hepatic steatosis: a role for de novo lipogenesis and the transcription factor SREBP-1c. Diabetes Obes Metab. 2010;12 Suppl 2:83-92 pubmed publisher..ER is thus a new partner in steatosis and metabolic syndrome which is worth considering as a potential therapeutic target. ..
- Menasche G, De Saint Basile G. EBAG9 tempers lymphocyte killing activity. J Clin Invest. 2009;119:2136-40 pubmed publisher..This finding adds a new piece to the puzzle of complex mechanisms that tightly regulate the capacity of the cytotoxic response and suggests a new target to negatively modulate CTL responsiveness. ..
- Gouya L, Muzeau F, Robreau A, Letteron P, Couchi E, Lyoumi S, et al. Genetic study of variation in normal mouse iron homeostasis reveals ceruloplasmin as an HFE-hemochromatosis modifier gene. Gastroenterology. 2007;132:679-86 pubmed..This study highlights the existence of complex interactions between Cp and HFE and represents the first example of a modifier gene with a protective effect, in which heterozygosity reduces the iron load in the context of HFE deficiency. ..
- Barreau F, Meinzer U, Chareyre F, Berrebi D, Niwa Kawakita M, Dussaillant M, et al. CARD15/NOD2 is required for Peyer's patches homeostasis in mice. PLoS ONE. 2007;2:e523 pubmed..These observations provide a comprehensive link between the molecular defect and the Human CARD15/NOD2 associated disorders: CD and GVHD. ..
- Cavazzana Calvo M, Payen E, Negre O, Wang G, Hehir K, Fusil F, et al. Transfusion independence and HMGA2 activation after gene therapy of human ?-thalassaemia. Nature. 2010;467:318-22 pubmed publisher..The clonal dominance that accompanies therapeutic efficacy may be coincidental and stochastic or result from a hitherto benign cell expansion caused by dysregulation of the HMGA2 gene in stem/progenitor cells. ..
- Picard E, Le Rouzic Q, Oudar A, Berdugo M, El Sanharawi M, Andrieu Soler C, et al. Targeting iron-mediated retinal degeneration by local delivery of transferrin. Free Radic Biol Med. 2015;89:1105-21 pubmed publisher..These results clearly demonstrate the synergistic neuroprotective roles of Tf against retinal degeneration and allow identify Tf as an innovative and not toxic therapy for retinal diseases associated with oxidative stress. ..
- Segretain D, Falk M. Regulation of connexin biosynthesis, assembly, gap junction formation, and removal. Biochim Biophys Acta. 2004;1662:3-21 pubmed
- Tourneur E, Chassin C. Neonatal immune adaptation of the gut and its role during infections. Clin Dev Immunol. 2013;2013:270301 pubmed publisher..This review summarizes the molecular events leading to the establishment of postnatal immune tolerance and how pathogens can avoid host immunity and induce neonatal infections and sepsis. ..
- Klein Wolterink R, Serafini N, van Nimwegen M, Vosshenrich C, de Bruijn M, Fonseca Pereira D, et al. Essential, dose-dependent role for the transcription factor Gata3 in the development of IL-5+ and IL-13+ type 2 innate lymphoid cells. Proc Natl Acad Sci U S A. 2013;110:10240-5 pubmed publisher..Collectively, these results identify Gata3 as a critical early regulator of ILC2 development, thereby extending the paradigm of Gata3-dependent control of type 2 immunity to include both innate and adaptive lymphocytes. ..
- Prie D, Torres P, Friedlander G. Phosphate handling: new genes, new molecules. Horm Res Paediatr. 2011;76 Suppl 1:71-5 pubmed publisher..This progress may allow development of new drugs that interfere with phosphate transporters, hormonal receptors or associated proteins to improve treatment and to help prevent secondary hyperparathyroidism. ..
- Beaumont M, Portune K, Steuer N, Lan A, Cerrudo V, Audebert M, et al. Quantity and source of dietary protein influence metabolite production by gut microbiota and rectal mucosa gene expression: a randomized, parallel, double-blind trial in overweight humans. Am J Clin Nutr. 2017;106:1005-1019 pubmed publisher..This trial was registered at clinicaltrials.gov as NCT02351297. ..
- Saadoun D, Rosenzwajg M, Landau D, Piette J, Klatzmann D, Cacoub P. Restoration of peripheral immune homeostasis after rituximab in mixed cryoglobulinemia vasculitis. Blood. 2008;111:5334-41 pubmed publisher..01). Our findings indicate that in patients with MC, response to B-cell depletion induced by rituximab effectively normalizes many of the disturbances in peripheral B- and T-lymphocyte homeostasis. ..
- Pontoglio M. Hepatocyte nuclear factor 1, a transcription factor at the crossroads of glucose homeostasis. J Am Soc Nephrol. 2000;11 Suppl 16:S140-3 pubmed..These data show that HNF1 is a major regulator of glucose homeostasis, regulating the expression of genes that are expressed in the liver, kidney, and pancreas. ..
- Orestes Cardoso S, Nefussi J, Hotton D, Mesbah M, Orestes Cardoso M, Robert B, et al. Postnatal Msx1 expression pattern in craniofacial, axial, and appendicular skeleton of transgenic mice from the first week until the second year. Dev Dyn. 2001;221:1-13 pubmed..The present study suggests that these signalling pathways are jointly important throughout the entire lifetime with an exquisite site-specificity spatially related to early patterning. ..
- Houard X, Goldring M, Berenbaum F. Homeostatic mechanisms in articular cartilage and role of inflammation in osteoarthritis. Curr Rheumatol Rep. 2013;15:375 pubmed publisher..This review focuses on mechanisms responsible for the maintenance of cartilage homeostasis and highlights the role of inflammatory processes in OA progression. ..
- Moulouel B, Houamel D, Delaby C, Tchernitchko D, Vaulont S, Letteron P, et al. Hepcidin regulates intrarenal iron handling at the distal nephron. Kidney Int. 2013;84:756-66 pubmed publisher..Thus, kidneys exhibit a tissue-specific handling of iron that depends on the extra iron source. Hepcidin may control the expression of iron transporters to prevent renal iron overload. ..
- Lalanne A, Moraga I, Hao Y, Pereira J, Alves N, Huntington N, et al. CpG inhibits pro-B cell expansion through a cathepsin B-dependent mechanism. J Immunol. 2010;184:5678-85 pubmed publisher..Thus, TLR9 signals can regulate B lymphopoiesis in vivo. ..
- Le Grand F, Grifone R, Mourikis P, Houbron C, Gigaud C, Pujol J, et al. Six1 regulates stem cell repair potential and self-renewal during skeletal muscle regeneration. J Cell Biol. 2012;198:815-32 pubmed publisher..We conclude that Six1 homeoproteins act as a rheostat system to ensure proper regeneration of the tissue and replenishment of the stem cell pool during the events that follow skeletal muscle trauma. ..
- Letavernier E, Rodenas A, Guerrot D, Haymann J. Williams-Beuren syndrome hypercalcemia: is TRPC3 a novel mediator in calcium homeostasis?. Pediatrics. 2012;129:e1626-30 pubmed publisher..This original observation prompts further investigation of TRPC3 as a novel actor of calcium homeostasis. ..
- Sawa S, Cherrier M, Lochner M, Satoh Takayama N, Fehling H, Langa F, et al. Lineage relationship analysis of RORgammat+ innate lymphoid cells. Science. 2010;330:665-9 pubmed publisher..Contrary to ROR?t(+) T cells, however, ROR?t(+) ILCs develop in the absence of microbiota. Our study indicates that ROR?t(+) ILCs evolve to preempt intestinal colonization by microbial symbionts...
- Klezovich Bénard M, Corre J, Jusforgues Saklani H, Fiole D, Burjek N, Tournier J, et al. Mechanisms of NK cell-macrophage Bacillus anthracis crosstalk: a balance between stimulation by spores and differential disruption by toxins. PLoS Pathog. 2012;8:e1002481 pubmed publisher..This highlights the potential implication of the crosstalk between host innate defences and B. anthracis in initial anthrax control mechanisms...
- Hill G, Heudes D, Bariety J. Morphometric study of arterioles and glomeruli in the aging kidney suggests focal loss of autoregulation. Kidney Int. 2003;63:1027-36 pubmed..Hyaline arteriolosclerosis of the nonobstructive sort is strongly associated with these changes and may play a role in their pathogenesis. ..
- Planelles G. Ammonium homeostasis and human Rhesus glycoproteins. Nephron Physiol. 2007;105:p11-7 pubmed..Direct NH(3) transport (associated or not with NH(4)(+) transport) raises the exciting hypothesis that Rh glycoproteins may also transport other gases than NH(3) (namely, CO(2)). ..
- Rueda P, Richart A, Recalde A, Gasse P, Vilar J, Guérin C, et al. Homeostatic and tissue reparation defaults in mice carrying selective genetic invalidation of CXCL12/proteoglycan interactions. Circulation. 2012;126:1882-95 pubmed publisher..These findings prove the role played by heparan sulfate interactions in the functions of CXCL12 in both homeostasis and physiopathological settings and document for the first time the paradigm of chemokine immobilization in vivo. ..
- Le Campion A, Pommier A, Delpoux A, Stouvenel L, Auffray C, Martin B, et al. IL-2 and IL-7 determine the homeostatic balance between the regulatory and conventional CD4+ T cell compartments during peripheral T cell reconstitution. J Immunol. 2012;189:3339-46 pubmed
- Stritt S, Nurden P, Favier R, Favier M, Ferioli S, Gotru S, et al. Defects in TRPM7 channel function deregulate thrombopoiesis through altered cellular Mg(2+) homeostasis and cytoskeletal architecture. Nat Commun. 2016;7:11097 pubmed publisher..Collectively, our findings reveal that TRPM7 dysfunction may cause macrothrombocytopenia in humans and mice. ..
- Brasse Lagnel C, Karim Z, Letteron P, Bekri S, Bado A, Beaumont C. Intestinal DMT1 cotransporter is down-regulated by hepcidin via proteasome internalization and degradation. Gastroenterology. 2011;140:1261-1271.e1 pubmed publisher..An acute increase in hepcidin concentration reduces intestinal iron absorption through ubiquitin-dependent proteasome degradation of DMT1. ..
- Gadadhar S, Dadi H, Bodakuntla S, Schnitzler A, BiÃ¨che I, Rusconi F, et al. Tubulin glycylation controls primary cilia length. J Cell Biol. 2017;216:2701-2713 pubmed publisher..This strongly suggests that glycylation is essential for the homeostasis of primary cilia, which has important implications for human disorders related to primary cilia dysfunctions, such as ciliopathies and certain types of cancer. ..
- Mastrogiannaki M, Matak P, Peyssonnaux C. The gut in iron homeostasis: role of HIF-2 under normal and pathological conditions. Blood. 2013;122:885-92 pubmed publisher..We also discuss implications for adapting HIF-2-based therapeutic strategies in iron-related pathological conditions. ..
- Hepp R, Tricoire L, Hu E, Gervasi N, Paupardin Tritsch D, Lambolez B, et al. Phosphodiesterase type 2 and the homeostasis of cyclic GMP in living thalamic neurons. J Neurochem. 2007;102:1875-1886 pubmed publisher..Basal cGMP level is poised at an intermediate level from which it can be up or down-regulated according to the cyclase and PDE activities. ..
- Teissier N, Delezoide A, Mas A, Khung Savatovsky S, Bessières B, Nardelli J, et al. Inner ear lesions in congenital cytomegalovirus infection of human fetuses. Acta Neuropathol. 2011;122:763-74 pubmed publisher..In addition, the occurrence of SNHL depends on the intensity and duration of the viral infection and inflammation...