Experts and Doctors on histones in Paris, Île de France, France


Locale: Paris, Île de France, France
Topic: histones

Top Publications

  1. Malmquist N, MOSS T, Mécheri S, Scherf A, Fuchter M. Small-molecule histone methyltransferase inhibitors display rapid antimalarial activity against all blood stage forms in Plasmodium falciparum. Proc Natl Acad Sci U S A. 2012;109:16708-13 pubmed publisher
  2. Gay S, Lachages A, Millot G, Courbet S, Letessier A, Debatisse M, et al. Nucleotide supply, not local histone acetylation, sets replication origin usage in transcribed regions. EMBO Rep. 2010;11:698-704 pubmed publisher
    ..Our findings reconcile results that seemed inconsistent and reveal an unsuspected effect of deacetylase inhibitors on replication dynamics. ..
  3. Hassan Zadeh V, Chilaka S, Cadoret J, Ma M, Boggetto N, West A, et al. USF binding sequences from the HS4 insulator element impose early replication timing on a vertebrate replicator. PLoS Biol. 2012;10:e1001277 pubmed publisher
    ..Taken together, our data identify a combination of cis-elements that might constitute the basic unit of multi-replicon megabase-sized early domains of DNA replication. ..
  4. Chen P, Ding S, Zanghi G, Soulard V, DiMaggio P, Fuchter M, et al. Plasmodium falciparum PfSET7: enzymatic characterization and cellular localization of a novel protein methyltransferase in sporozoite, liver and erythrocytic stage parasites. Sci Rep. 2016;6:21802 pubmed publisher
  5. Adam S, Polo S, Almouzni G. How to restore chromatin structure and function in response to DNA damage--let the chaperones play: delivered on 9 July 2013 at the 38th FEBS Congress in St Petersburg, Russia. FEBS J. 2014;281:2315-23 pubmed publisher
    ..Finally, we discuss how, in addition to restoring chromatin integrity, the cellular networks that signal and repair DNA damage may also provide a window of opportunity for modulating the information conveyed by chromatin. ..
  6. Soares D, Battistella A, Rocca C, Matuo R, Henriques J, Larsen A, et al. Ataxia telangiectasia mutated- and Rad3-related kinase drives both the early and the late DNA-damage response to the monofunctional antitumour alkylator S23906. Biochem J. 2011;437:63-73 pubmed publisher
    ..These findings identify ATR as a central co-ordinator of the DNA-damage response to S23906, and provide a mechanistic rationale for combinations of S23906 and similar agents with checkpoint abrogators. ..
  7. Ghislin S, Deshayes F, Lauriol J, Middendorp S, Martins I, Al Daccak R, et al. Plasticity of melanoma cells induced by neural cell crest conditions and three-dimensional growth. Melanoma Res. 2012;22:184-94 pubmed publisher
    ..This in-vitro model will allow further characterization and targeting of melanoma invasive cell populations. ..
  8. Bertran Gonzalez J, Bosch C, Maroteaux M, Matamales M, Herve D, Valjent E, et al. Opposing patterns of signaling activation in dopamine D1 and D2 receptor-expressing striatal neurons in response to cocaine and haloperidol. J Neurosci. 2008;28:5671-85 pubmed publisher
  9. Raymond B, Batsche E, Boutillon F, Wu Y, Leduc D, Balloy V, et al. Anthrax lethal toxin impairs IL-8 expression in epithelial cells through inhibition of histone H3 modification. PLoS Pathog. 2009;5:e1000359 pubmed publisher
    ..This epigenetic reprogramming, in addition to previously reported effects of LT, may represent an efficient strategy used by B. anthracis for invading the host. ..

More Information


  1. Lopez Rubio J, Gontijo A, Nunes M, Issar N, Hernandez Rivas R, Scherf A. 5' flanking region of var genes nucleate histone modification patterns linked to phenotypic inheritance of virulence traits in malaria parasites. Mol Microbiol. 2007;66:1296-305 pubmed
    ..Our work points to a pivotal role of the histone methyl mark writing and reading machinery in the phenotypic inheritance of virulence traits in the malaria parasite. ..
  2. Genin P, Lin R, Hiscott J, Civas A. Recruitment of histone deacetylase 3 to the interferon-A gene promoters attenuates interferon expression. PLoS ONE. 2012;7:e38336 pubmed publisher
    ..Altogether these data indicate that reversal of histone H3K9/K14 acetylation by HDAC3 is required for attenuation of IFN-A gene transcription during viral infection. ..
  3. Pennini M, Perrinet S, Dautry Varsat A, Subtil A. Histone methylation by NUE, a novel nuclear effector of the intracellular pathogen Chlamydia trachomatis. PLoS Pathog. 2010;6:e1000995 pubmed publisher
    ..Thus, NUE is secreted by Chlamydia, translocates to the host cell nucleus and has enzymatic activity towards eukaryotic substrates. This work is the first description of a bacterial effector that directly targets mammalian histones. ..
  4. Azouz A, Wu Y, Hillion J, Tarkanyi I, Karniguian A, Aradi J, et al. Epigenetic plasticity of hTERT gene promoter determines retinoid capacity to repress telomerase in maturation-resistant acute promyelocytic leukemia cells. Leukemia. 2010;24:613-22 pubmed publisher
    ..We propose that epigenetic modifications targeting this distal region could modulate the binding of hTERT repressors and account either for hTERT reactivation and resistance to retinoid-induced hTERT downregulation. ..
  5. Cavazza A, Miccio A, Romano O, Petiti L, Malagoli Tagliazucchi G, Peano C, et al. Dynamic Transcriptional and Epigenetic Regulation of Human Epidermal Keratinocyte Differentiation. Stem Cell Reports. 2016;6:618-632 pubmed publisher
  6. Walter M, Teissandier A, Pérez Palacios R, Bourc his D. An epigenetic switch ensures transposon repression upon dynamic loss of DNA methylation in embryonic stem cells. elife. 2016;5: pubmed publisher
  7. Padilla Parra S, Audugé N, Lalucque H, Mevel J, Coppey Moisan M, Tramier M. Quantitative comparison of different fluorescent protein couples for fast FRET-FLIM acquisition. Biophys J. 2009;97:2368-76 pubmed publisher
    ..In this particular case, the fluorescence intensity was more stable for EGFP-H4 than for mTFP1-H4. Nevertheless, we show that mTFP1/EYFP stands alone as the best FRET-FLIM couple in terms of f(D) analysis. ..
  8. Godier A, Hunt B. Plasminogen receptors and their role in the pathogenesis of inflammatory, autoimmune and malignant disease. J Thromb Haemost. 2013;11:26-34 pubmed publisher
    ..This review will discuss currently available information on plasminogen receptors, particularly their mechanisms of action and their roles in inflammatory, autoimmune and malignant disease. ..
  9. Bourbousse C, Ahmed I, Roudier F, Zabulon G, Blondet E, Balzergue S, et al. Histone H2B monoubiquitination facilitates the rapid modulation of gene expression during Arabidopsis photomorphogenesis. PLoS Genet. 2012;8:e1002825 pubmed publisher
    ..Based on these findings, we propose that H2B monoubiquitination is part of a transcription-coupled, chromatin-based mechanism to rapidly modulate gene expression. ..
  10. Toledano E, Ogryzko V, Danchin A, Ladant D, Mechold U. 3'-5' phosphoadenosine phosphate is an inhibitor of PARP-1 and a potential mediator of the lithium-dependent inhibition of PARP-1 in vivo. Biochem J. 2012;443:485-90 pubmed publisher
    ..From these results, we propose that pAp might be a physiological regulator of PARP-1 activity. ..
  11. Mozzetta C, Pontis J, Fritsch L, Robin P, Portoso M, Proux C, et al. The histone H3 lysine 9 methyltransferases G9a and GLP regulate polycomb repressive complex 2-mediated gene silencing. Mol Cell. 2014;53:277-89 pubmed publisher
    ..Taken together, our findings demonstrate an unanticipated interplay between two main histone lysine methylation mechanisms, which cooperate to maintain silencing of a subset of developmental genes. ..
  12. Jordi E, Heiman M, Marion Poll L, Guermonprez P, Cheng S, Nairn A, et al. Differential effects of cocaine on histone posttranslational modifications in identified populations of striatal neurons. Proc Natl Acad Sci U S A. 2013;110:9511-6 pubmed publisher
    ..The method described should have general utility for studying nuclear modifications in different types of neuronal or nonneuronal cell types. ..
  13. Bertran Gonzalez J, Hakansson K, Borgkvist A, Irinopoulou T, Brami Cherrier K, Usiello A, et al. Histone H3 phosphorylation is under the opposite tonic control of dopamine D2 and adenosine A2A receptors in striatopallidal neurons. Neuropsychopharmacology. 2009;34:1710-20 pubmed publisher
    ..Thus, blockade of D2Rs promotes histone H3 phosphorylation through the A2AR-mediated activation of Galpha(olf) and inhibition of protein phosphatase-1 (PP-1) through the PKA-dependent phosphorylation of DARPP-32. ..
  14. Baritaud M, Boujrad H, Lorenzo H, Krantic S, Susin S. Histone H2AX: The missing link in AIF-mediated caspase-independent programmed necrosis. Cell Cycle. 2010;9:3166-73 pubmed
    ..In the present article, we outline the current knowledge on cell death by programmed necrosis and discuss the relevance of the AIF/H2AX/CypA DNA-degrading complex in the regulation of this original form of cell death. ..
  15. Ridinger Saison M, Evanno E, Gallais I, Rimmelé P, Selimoglu Buet D, Sapharikas E, et al. Epigenetic silencing of Bim transcription by Spi-1/PU.1 promotes apoptosis resistance in leukaemia. Cell Death Differ. 2013;20:1268-78 pubmed publisher
    ..Our results identify a new mechanism whereby Spi-1 represses transcription and provide mechanistic insights on the antiapoptotic function of a transcription factor mediated by the epigenetic control of gene expression. ..
  16. Haque F, Varlet P, Puntonet J, Storer L, Bountali A, Rahman R, et al. Evaluation of a novel antibody to define histone 3.3 G34R mutant brain tumours. Acta Neuropathol Commun. 2017;5:45 pubmed publisher
  17. Ray Gallet D, Woolfe A, Vassias I, Pellentz C, Lacoste N, Puri A, et al. Dynamics of histone H3 deposition in vivo reveal a nucleosome gap-filling mechanism for H3.3 to maintain chromatin integrity. Mol Cell. 2011;44:928-41 pubmed publisher
    ..3, and HIRA association with Pol II ensures local H3.3 enrichment at specific sites. We discuss the importance of this H3.3 deposition as a salvage pathway to maintain chromatin integrity. ..
  18. Ferry L, Fournier A, Tsusaka T, Adelmant G, Shimazu T, Matano S, et al. Methylation of DNA Ligase 1 by G9a/GLP Recruits UHRF1 to Replicating DNA and Regulates DNA Methylation. Mol Cell. 2017;67:550-565.e5 pubmed publisher
    ..These results further elucidate the function of UHRF1, identify a non-histone target of G9a and GLP, and provide an example of a histone mimic that coordinates DNA replication and DNA methylation maintenance. ..
  19. Escamilla Del Arenal M, da Rocha S, Heard E. Evolutionary diversity and developmental regulation of X-chromosome inactivation. Hum Genet. 2011;130:307-27 pubmed publisher
  20. Borde V, Robine N, Lin W, Bonfils S, Geli V, Nicolas A. Histone H3 lysine 4 trimethylation marks meiotic recombination initiation sites. EMBO J. 2009;28:99-111 pubmed publisher
    ..Novel perspectives to dissect the various layers of the controls of meiotic DSB formation are discussed. ..
  21. Loyola A, Bonaldi T, Roche D, Imhof A, Almouzni G. PTMs on H3 variants before chromatin assembly potentiate their final epigenetic state. Mol Cell. 2006;24:309-16 pubmed
    ..Although the set of initial modifications present on H3.1 is permissive for further modifications, in H3.3 a subset cannot be K9me3. Thus, initial modifications impact final PTMs within chromatin. ..
  22. Clement C, Almouzni G. MCM2 binding to histones H3-H4 and ASF1 supports a tetramer-to-dimer model for histone inheritance at the replication fork. Nat Struct Mol Biol. 2015;22:587-9 pubmed publisher
  23. Jacquemin V, Rieunier G, Jacob S, Bellanger D, d Enghien C, Lauge A, et al. Underexpression and abnormal localization of ATM products in ataxia telangiectasia patients bearing ATM missense mutations. Eur J Hum Genet. 2012;20:305-12 pubmed publisher
    ..This new finding highlights ATM mislocalization as a new mechanism of ATM dysfunction, which may lead to therapeutic strategies for missense mutation associated A-T...
  24. Bierne H, Tham T, Batsche E, Dumay A, Leguillou M, Kernéis Golsteyn S, et al. Human BAHD1 promotes heterochromatic gene silencing. Proc Natl Acad Sci U S A. 2009;106:13826-31 pubmed publisher
    ..Collectively, these findings provide evidence that BAHD1 acts as a silencer by recruiting at specific promoters a set of proteins that coordinate heterochromatin assembly. ..
  25. Mauvieux L, Villey I, de Villartay J. TEA regulates local TCR-Jalpha accessibility through histone acetylation. Eur J Immunol. 2003;33:2216-22 pubmed
    ..TEA-dependent histone acetylation of the most upstream Jalpha segments leads to enhanced DNA accessibility thus optimizing TCRJalpha usage and increasing Ag receptor diversity potential. ..
  26. Roudier F, Ahmed I, Bérard C, Sarazin A, Mary Huard T, Cortijo S, et al. Integrative epigenomic mapping defines four main chromatin states in Arabidopsis. EMBO J. 2011;30:1928-38 pubmed publisher
    ..This first combinatorial view of the Arabidopsis epigenome points to simple principles of organization as in metazoans and provides a framework for further studies of chromatin-based regulatory mechanisms in plants. ..
  27. Okamoto I, Patrat C, Thepot D, Peynot N, Fauque P, Daniel N, et al. Eutherian mammals use diverse strategies to initiate X-chromosome inactivation during development. Nature. 2011;472:370-4 pubmed publisher
    ..Our study demonstrates the remarkable diversity in XCI regulation and highlights differences between mammals in their requirement for dosage compensation during early embryogenesis...
  28. Pineau P, Henry M, Susp ne R, Marchio A, Dettai A, Debruyne R, et al. A universal primer set for PCR amplification of nuclear histone H4 genes from all animal species. Mol Biol Evol. 2005;22:582-8 pubmed publisher
    ..The data indicate that the HIST2H4 amplimers are, thus, suitable for both DNA quality testing as well as species identification in the animal kingdom...
  29. Saint André V, Batsche E, Rachez C, Muchardt C. Histone H3 lysine 9 trimethylation and HP1? favor inclusion of alternative exons. Nat Struct Mol Biol. 2011;18:337-44 pubmed publisher
    ..They further implicate HP1? as a possible bridging molecule between the chromatin and the maturating mRNA, with a general impact on splicing decisions. ..
  30. Cassinat B, Zassadowski F, Ferry C, Llopis L, Bruck N, Lainey E, et al. New role for granulocyte colony-stimulating factor-induced extracellular signal-regulated kinase 1/2 in histone modification and retinoic acid receptor ? recruitment to gene promoters: relevance to acute promyelocytic leukemia cell differentiation. Mol Cell Biol. 2011;31:1409-18 pubmed publisher
    ..Thus, combinatorial activation of cytokines and RARs potentiates transcriptional activity through epigenetic modifications induced by specific signaling pathways. ..
  31. Guillemin C, Maleszewska M, Guais A, Maës J, Rouyez M, Yacia A, et al. Chromatin modifications in hematopoietic multipotent and committed progenitors are independent of gene subnuclear positioning relative to repressive compartments. Stem Cells. 2009;27:108-15 pubmed publisher
  32. Szekvolgyi L, Nicolas A. From meiosis to postmeiotic events: homologous recombination is obligatory but flexible. FEBS J. 2010;277:571-89 pubmed publisher
    ..Flexibility in the distribution of meiotic recombination events within genomes may reside in regulation at the chromatin level, with histone modifications playing a recently recognized role. ..
  33. Sommermeyer V, Béneut C, Chaplais E, Serrentino M, Borde V. Spp1, a member of the Set1 Complex, promotes meiotic DSB formation in promoters by tethering histone H3K4 methylation sites to chromosome axes. Mol Cell. 2013;49:43-54 pubmed publisher
    ..This paper provides the molecular mechanism linking DSB sequences to chromosome axes and explains why H3K4 methylation is important for meiotic recombination. ..
  34. Herbert S, Brion A, Arbona J, Lelek M, Veillet A, Lelandais B, et al. Chromatin stiffening underlies enhanced locus mobility after DNA damage in budding yeast. EMBO J. 2017;36:2595-2608 pubmed publisher
    ..Our results support a genome-wide stiffening of the chromatin fiber as a consequence of DNA damage and as a novel mechanism underlying increased chromatin mobility. ..
  35. Brustel J, Kirstein N, Izard F, Grimaud C, Prorok P, Cayrou C, et al. Histone H4K20 tri-methylation at late-firing origins ensures timely heterochromatin replication. EMBO J. 2017;36:2726-2741 pubmed publisher
    ..Altogether, these results reveal Suv4-20h-mediated H4K20 tri-methylation as a critical determinant in the selection of active replication initiation sites in heterochromatin regions of mammalian genomes. ..
  36. De Wever O, Sobczak Thepot J, Vercoutter Edouart A, Michalski J, Ouelaa Benslama R, Stupack D, et al. Priming and potentiation of DNA damage response by fibronectin in human colon cancer cells and tumor-derived myofibroblasts. Int J Oncol. 2011;39:393-400 pubmed publisher
    ..These data provide evidence that FN promotes DNA damage recognition and chemosensitization to cisplatin via the potentiation of the DNA damage signaling responses in human colon cancer cells and tumor-derived myofibroblasts. ..
  37. Duffié R, Ajjan S, Greenberg M, Zamudio N, Escamilla Del Arenal M, Iranzo J, et al. The Gpr1/Zdbf2 locus provides new paradigms for transient and dynamic genomic imprinting in mammals. Genes Dev. 2014;28:463-78 pubmed publisher
    ..Together, our work underlines the developmental and evolutionary need to ensure proper Liz/Zdbf2 dosage as a driving force for dynamic genomic imprinting at the Gpr1/Zdbf2 locus. ..
  38. Iouzalen N, Moreau J, Mechali M. H2A.ZI, a new variant histone expressed during Xenopus early development exhibits several distinct features from the core histone H2A. Nucleic Acids Res. 1996;24:3947-52 pubmed
    ..The characteristics of H2A.ZI suggest that its incorporation into nucleosomes would lead to a chromatin structure more competent for gene expression during development. ..
  39. Letouze E, Martinelli C, Loriot C, Burnichon N, Abermil N, Ottolenghi C, et al. SDH mutations establish a hypermethylator phenotype in paraganglioma. Cancer Cell. 2013;23:739-52 pubmed publisher
    ..Finally, inactivating FH mutations were identified in the only hypermethylated tumor without SDHx mutations. These findings emphasize the interplay between the Krebs cycle, epigenomic changes, and cancer...
  40. Surdez D, Benetkiewicz M, Perrin V, Han Z, Pierron G, Ballet S, et al. Targeting the EWSR1-FLI1 oncogene-induced protein kinase PKC-? abolishes ewing sarcoma growth. Cancer Res. 2012;72:4494-503 pubmed
    ..Taken together, our findings offer a preclinical proof-of-concept for PRKCB as a promising therapeutic target in Ewing sarcoma. ..
  41. Dunleavy E, Roche D, Tagami H, Lacoste N, Ray Gallet D, Nakamura Y, et al. HJURP is a cell-cycle-dependent maintenance and deposition factor of CENP-A at centromeres. Cell. 2009;137:485-97 pubmed publisher
    ..We conclude that HJURP is a key factor for CENP-A deposition and maintenance at centromeres. ..
  42. Gatto S, Gagliardi M, Franzese M, Leppert S, Papa M, Cammisa M, et al. ICF-specific DNMT3B dysfunction interferes with intragenic regulation of mRNA transcription and alternative splicing. Nucleic Acids Res. 2017;45:5739-5756 pubmed publisher
    ..Our genome-scale approach sheds light on the mechanisms still poorly understood of the intragenic function of DNMT3B and DNA methylation in gene expression regulation. ..
  43. Dastidar E, Dzeyk K, Krijgsveld J, Malmquist N, Doerig C, Scherf A, et al. Comprehensive histone phosphorylation analysis and identification of Pf14-3-3 protein as a histone H3 phosphorylation reader in malaria parasites. PLoS ONE. 2013;8:e53179 pubmed publisher
    ..The identification of a second member of the histone modification reading machinery suggests a widespread use of histone phosphorylation in the control of various nuclear processes in malaria parasites. ..
  44. Veron M, Zou Y, Yu Q, Bi X, Selmi A, Gilson E, et al. Histone H1 of Saccharomyces cerevisiae inhibits transcriptional silencing. Genetics. 2006;173:579-87 pubmed
    ..Histone H1 is a linker histone that binds the outside of nucleosomes and modifies chromatin dynamics. Here we show that Hho1p reinforces the action of several types of barrier elements, and also inhibits silencing on its own. ..
  45. Lopez Rubio J, Mancio Silva L, Scherf A. Genome-wide analysis of heterochromatin associates clonally variant gene regulation with perinuclear repressive centers in malaria parasites. Cell Host Microbe. 2009;5:179-90 pubmed publisher
    ..Our data point to the existence of perinuclear repressive centers associated with control of expression of malaria parasite genes involved in phenotypic variation and pathogenesis. ..
  46. Rolando M, Sanulli S, Rusniok C, Gomez Valero L, Bertholet C, Sahr T, et al. Legionella pneumophila effector RomA uniquely modifies host chromatin to repress gene expression and promote intracellular bacterial replication. Cell Host Microbe. 2013;13:395-405 pubmed publisher
    ..Thus, a secreted L. pneumophila effector targets the host cell nucleus and modifies histones to repress gene expression and promote efficient intracellular replication...
  47. Margueron R, Reinberg D. The Polycomb complex PRC2 and its mark in life. Nature. 2011;469:343-9 pubmed publisher
    ..Recent studies of PRC2 have expanded our perspectives on its function and regulation, and uncovered a role for non-coding RNA in the recruitment of PRC2 to target genes. ..
  48. Le Romancer M, Reyl Desmars F, Cherifi Y, Pigeon C, Bottari S, Meyer O, et al. The 86-kDa subunit of autoantigen Ku is a somatostatin receptor regulating protein phosphatase-2A activity. J Biol Chem. 1994;269:17464-8 pubmed
    ..Given the key role played by PP2A in cell cycle regulation, the current findings suggest that p86-Ku could be a physiological target of somatostatin antiproliferative action. ..
  49. Sharma P, Azebi S, England P, Christensen T, Møller Larsen A, Petersen T, et al. Citrullination of histone H3 interferes with HP1-mediated transcriptional repression. PLoS Genet. 2012;8:e1002934 pubmed publisher
  50. Baritaud M, Cabon L, Delavallée L, Galán Malo P, Gilles M, Brunelle Navas M, et al. AIF-mediated caspase-independent necroptosis requires ATM and DNA-PK-induced histone H2AX Ser139 phosphorylation. Cell Death Dis. 2012;3:e390 pubmed publisher
    ..Further, DNA-PK contributes to H2AX Ser139 phosphorylation. In revealing the pivotal role of PIKKs in MNNG-induced cell death, our data uncover a milestone in the mechanisms regulating AIF-mediated caspase-independent necroptosis. ..
  51. Artus C, Boujrad H, Bouharrour A, Brunelle M, Hoos S, Yuste V, et al. AIF promotes chromatinolysis and caspase-independent programmed necrosis by interacting with histone H2AX. EMBO J. 2010;29:1585-99 pubmed publisher
    ..Overall, our data shed new light in the mechanisms regulating programmed necrosis, elucidate a key nuclear partner of AIF, and uncover an AIF apoptogenic motif. ..
  52. Balandina A, Claret L, Hengge Aronis R, Rouviere Yaniv J. The Escherichia coli histone-like protein HU regulates rpoS translation. Mol Microbiol. 2001;39:1069-79 pubmed
    ..We demonstrate here that HU, an abundant DNA-binding, histone-like protein, is able specifically to recognize an RNA molecule and therefore play a role in post-transcriptional regulation. ..
  53. Dembele L, Franetich J, Lorthiois A, Gego A, Zeeman A, Kocken C, et al. Persistence and activation of malaria hypnozoites in long-term primary hepatocyte cultures. Nat Med. 2014;20:307-12 pubmed publisher
    ..The protocol presented may further enable investigations of hypnozoite biology and the search for compounds that kill hypnozoites or disrupt their quiescence. ..
  54. Escamilla Del Arenal M, da Rocha S, Spruijt C, Masui O, Renaud O, Smits A, et al. Cdyl, a new partner of the inactive X chromosome and potential reader of H3K27me3 and H3K9me2. Mol Cell Biol. 2013;33:5005-20 pubmed publisher
    ..We propose that the combination of H3K9me2 and H3K27me3 recruits Cdyl to Xi, and this, in turn, may facilitate propagation of the H3K9me2 mark by anchoring G9a. ..
  55. Munier A, Feral C, Milon L, Pinon V, Gyapay G, Capeau J, et al. A new human nm23 homologue (nm23-H5) specifically expressed in testis germinal cells. FEBS Lett. 1998;434:289-94 pubmed
    ..However, under usual assay conditions, Nm23-H5 expressed in Escherichia coli did not exhibit NDP kinase activity. These results suggest that Nm23-H5 is specifically involved in early stages of spermatogenesis. ..
  56. Okamoto I, Otte A, Allis C, Reinberg D, Heard E. Epigenetic dynamics of imprinted X inactivation during early mouse development. Science. 2004;303:644-9 pubmed
    ..This reveals the remarkable plasticity of the X-inactivation process during preimplantation development and underlines the importance of the ICM in global reprogramming of epigenetic marks in the early embryo...
  57. Havis E, Anselme I, Schneider Maunoury S. Whole embryo chromatin immunoprecipitation protocol for the in vivo study of zebrafish development. Biotechniques. 2006;40:34, 36, 38 passim pubmed
  58. Feyder M, Södersten E, Santini E, Vialou V, LaPlant Q, Watts E, et al. A Role for Mitogen- and Stress-Activated Kinase 1 in L-DOPA-Induced Dyskinesia and ∆FosB Expression. Biol Psychiatry. 2016;79:362-71 pubmed publisher
    ..Results also show that accumulation of ∆FosB in striatonigral neurons is causally related to the development of dyskinesia. ..
  59. Cock Rada A, Medjkane S, Janski N, Yousfi N, Perichon M, Chaussepied M, et al. SMYD3 promotes cancer invasion by epigenetic upregulation of the metalloproteinase MMP-9. Cancer Res. 2012;72:810-20 pubmed publisher
    ..Together, our results define SMYD3 as an important new regulator of MMP-9 transcription, and they provide a molecular link between SMYD3 overexpression and metastatic cancer progression. ..
  60. Eskandarian H, Impens F, Nahori M, Soubigou G, Coppee J, Cossart P, et al. A role for SIRT2-dependent histone H3K18 deacetylation in bacterial infection. Science. 2013;341:1238858 pubmed publisher
    ..Thus, SIRT2-mediated H3K18 deacetylation plays a critical role during infection, which reveals an epigenetic mechanism imposed by a pathogenic bacterium to reprogram its host. ..
  61. Stipanovich A, Valjent E, Matamales M, Nishi A, Ahn J, Maroteaux M, et al. A phosphatase cascade by which rewarding stimuli control nucleosomal response. Nature. 2008;453:879-84 pubmed publisher
    ..Mutation of Ser 97 profoundly alters behavioural effects of drugs of abuse and decreases motivation for food, underlining the functional importance of this signalling cascade. ..
  62. Corpet A, Almouzni G. A histone code for the DNA damage response in mammalian cells?. EMBO J. 2009;28:1828-30 pubmed publisher
  63. Lavigne M, Eskeland R, Azebi S, Saint André V, Jang S, Batsche E, et al. Interaction of HP1 and Brg1/Brm with the globular domain of histone H3 is required for HP1-mediated repression. PLoS Genet. 2009;5:e1000769 pubmed publisher
    ..Altogether, our data suggest that HP1 chromoshadow-domains can benefit from the opening of nucleosomal structures to bind chromatin and that HP1 proteins use this property to detect and arrest unwanted chromatin remodeling. ..
  64. Bonnefoy E, Rouviere Yaniv J. HU and IHF, two homologous histone-like proteins of Escherichia coli, form different protein-DNA complexes with short DNA fragments. EMBO J. 1991;10:687-96 pubmed
    ..coli (IHF) form different structures with the same DNA fragments. Moreover, HU seems to enhance the DNA-binding capacity of IHF to a DNA fragment which does not contain its consensus sequence. ..
  65. Lacoste N, Woolfe A, Tachiwana H, Garea A, Barth T, Cantaloube S, et al. Mislocalization of the centromeric histone variant CenH3/CENP-A in human cells depends on the chaperone DAXX. Mol Cell. 2014;53:631-44 pubmed publisher
    ..Our findings illustrate how changes in histone variant levels can disrupt chromatin dynamics and suggests a possible mechanism for cell resistance to anticancer treatments. ..
  66. Catoire H, Pasco M, Abu Baker A, Holbert S, Tourette C, Brais B, et al. Sirtuin inhibition protects from the polyalanine muscular dystrophy protein PABPN1. Hum Mol Genet. 2008;17:2108-17 pubmed publisher
    ..Altogether, our data identify Sir2 and AMPK inhibition as therapeutic strategies for muscle protection in OPMD, extending the value of druggable proteins in cell maintenance networks to polyalanine diseases...
  67. Morey C, Navarro P, Debrand E, Avner P, Rougeulle C, Clerc P. The region 3' to Xist mediates X chromosome counting and H3 Lys-4 dimethylation within the Xist gene. EMBO J. 2004;23:594-604 pubmed
    ..Our results raise the possibility that H3 Lys-4 dimethylation within Xist may be functionally implicated in the counting process...
  68. Granger V, Faille D, Marani V, Noel B, Gallais Y, Szely N, et al. Human blood monocytes are able to form extracellular traps. J Leukoc Biol. 2017;102:775-781 pubmed publisher
    ..This new cellular mechanism is likely to have implications in the multiple pathologic contexts where monocytes are implicated, such as inflammatory disorders, infection, or thrombosis. ..
  69. Blouin J, Penot G, Collinet M, Nacfer M, Forest C, Laurent Puig P, et al. Butyrate elicits a metabolic switch in human colon cancer cells by targeting the pyruvate dehydrogenase complex. Int J Cancer. 2011;128:2591-601 pubmed publisher
  70. Koutouzov S, Cabrespines A, Amoura Z, Chabre H, Lotton C, Bach J. Binding of nucleosomes to a cell surface receptor: redistribution and endocytosis in the presence of lupus antibodies. Eur J Immunol. 1996;26:472-86 pubmed
    ..We also show that anti-ds DNA and anti-histone antibodies can form nucleosome-anti-nucleosome immune complexes in situ at the cell surface, and thus dramatically enhance the kinetics of nucleosome endocytosis. ..
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