Genomes and Genes
Experts and Doctors on genetic transcription in Paris, Île de France, France
Locale: Paris, Île de France, France
Topic: genetic transcription
Publications179 found, 100 shown here
- Kadri Z, Maouche Chretien L, Rooke H, Orkin S, Romeo P, Mayeux P, et al. Phosphatidylinositol 3-kinase/Akt induced by erythropoietin renders the erythroid differentiation factor GATA-1 competent for TIMP-1 gene transactivation. Mol Cell Biol. 2005;25:7412-22 pubmed..These findings provide the first example of a chain of coupling mechanisms between the binding of erythropoietin to its receptor and GATA-1-dependent gene expression. ..
- Vogel R, Mammeri H, Mallet J. Lentiviral vectors mediate nonimmunosuppressive rapamycin analog-induced production of secreted therapeutic factors in the brain: regulation at the level of transcription and exocytosis. Hum Gene Ther. 2008;19:167-78 pubmed publisher..In vivo, tightly regulated production of GFP and GDNF was observed after injection of the constructs into the striata of mice. The vectors thus fulfill key requirements for application in gene therapy. ..
- Patrat C, Okamoto I, Diabangouaya P, Vialon V, Le Baccon P, Chow J, et al. Dynamic changes in paternal X-chromosome activity during imprinted X-chromosome inactivation in mice. Proc Natl Acad Sci U S A. 2009;106:5198-203 pubmed publisher..These results reveal that imprinted X inactivation in mice is far less concerted than previously thought and highlight the epigenetic diversity underlying the dosage compensation process during early mammalian development. ..
- Ben Arous J, Laffont S, Chatenay D. Molecular and sensory basis of a food related two-state behavior in C. elegans. PLoS ONE. 2009;4:e7584 pubmed publisher..Biogenic amines signaling could allow the worm to adapt to fast changes in the environment when peptide transcriptional pathways may mediate slower adaptive changes. ..
- Gay S, Lachages A, Millot G, Courbet S, Letessier A, Debatisse M, et al. Nucleotide supply, not local histone acetylation, sets replication origin usage in transcribed regions. EMBO Rep. 2010;11:698-704 pubmed publisher..Our findings reconcile results that seemed inconsistent and reveal an unsuspected effect of deacetylase inhibitors on replication dynamics. ..
- Koike S, Schaeffer L, Changeux J. Identification of a DNA element determining synaptic expression of the mouse acetylcholine receptor delta-subunit gene. Proc Natl Acad Sci U S A. 1995;92:10624-8 pubmed
- Muchardt C, Yaniv M. A human homologue of Saccharomyces cerevisiae SNF2/SWI2 and Drosophila brm genes potentiates transcriptional activation by the glucocorticoid receptor. EMBO J. 1993;12:4279-90 pubmed..The co-operation between hbrm and GR required the DNA binding domain of GR and two separated regions of the hbrm protein, including a domain with homology to known helicases. ..
- Francetic O, Pugsley A. The cryptic general secretory pathway (gsp) operon of Escherichia coli K-12 encodes functional proteins. J Bacteriol. 1996;178:3544-9 pubmed..Thus, the gsp operon of E. coli K-12 includes at least two functional genes which, together with the rest of the operon, are probably not expressed under laboratory conditions. ..
- Patry C, Sibille Y, Lehuen A, Monteiro R. Identification of Fc alpha receptor (CD89) isoforms generated by alternative splicing that are differentially expressed between blood monocytes and alveolar macrophages. J Immunol. 1996;156:4442-8 pubmed..2 isoform, that might have physiologic relevance in IgA-mediated host defense at mucosal sites. ..
- Villey I, Caillol D, Selz F, Ferrier P, de Villartay J. Defect in rearrangement of the most 5' TCR-J alpha following targeted deletion of T early alpha (TEA): implications for TCR alpha locus accessibility. Immunity. 1996;5:331-42 pubmed..These results are consistent with TEA acting as a "rearrangement-focusing" element, targeting the primary waves of V alpha-J alpha recombination to the most 5' J alpha S in an ongoing TCR-J alpha rearrangement model. ..
- Iouzalen N, Moreau J, Mechali M. H2A.ZI, a new variant histone expressed during Xenopus early development exhibits several distinct features from the core histone H2A. Nucleic Acids Res. 1996;24:3947-52 pubmed..The characteristics of H2A.ZI suggest that its incorporation into nucleosomes would lead to a chromatin structure more competent for gene expression during development. ..
- Santacruz H, Vriz S, Angelier N. Molecular characterization of a heat shock cognate cDNA of zebrafish, hsc70, and developmental expression of the corresponding transcripts. Dev Genet. 1997;21:223-33 pubmed..These results suggest that the hsc70 gene may be involved in developmental differentiation events. ..
- Nair S, Frehel C, Nguyen L, Escuyer V, Berche P. ClpE, a novel member of the HSP100 family, is involved in cell division and virulence of Listeria monocytogenes. Mol Microbiol. 1999;31:185-96 pubmed..These results show that the Clp chaperones play a crucial role in both cell division and virulence of L. monocytogenes...
- Desbois Mouthon C, Cadoret A, Blivet Van Eggelpoël M, Bertrand F, Cherqui G, Perret C, et al. Insulin and IGF-1 stimulate the beta-catenin pathway through two signalling cascades involving GSK-3beta inhibition and Ras activation. Oncogene. 2001;20:252-9 pubmed..These findings demonstrate for the first time the ability of insulin and IGF-1 to activate the beta-catenin pathway in hepatoma cells and thereby provide new insights into the role of these factors in hepatocarcinogenesis. ..
- Blin Wakkach C, Lezot F, Ghoul Mazgar S, Hotton D, Monteiro S, Teillaud C, et al. Endogenous Msx1 antisense transcript: in vivo and in vitro evidences, structure, and potential involvement in skeleton development in mammals. Proc Natl Acad Sci U S A. 2001;98:7336-41 pubmed
- Abachin E, Poyart C, Pellegrini E, Milohanic E, Fiedler F, Berche P, et al. Formation of D-alanyl-lipoteichoic acid is required for adhesion and virulence of Listeria monocytogenes. Mol Microbiol. 2002;43:1-14 pubmed..These results show that the D-alanylation of the LTAs contributes to the virulence of the intracellular pathogen L. monocytogenes. ..
- Uchida T, Rossignol F, Matthay M, Mounier R, Couette S, Clottes E, et al. Prolonged hypoxia differentially regulates hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha expression in lung epithelial cells: implication of natural antisense HIF-1alpha. J Biol Chem. 2004;279:14871-8 pubmed..This trans-regulation between HIF-1alpha and HIF-2alpha during hypoxia likely conveys target gene specificity. ..
- Cheval L, Duong Van Huyen J, Bruneval P, Verbavatz J, Elalouf J, Doucet A. Plasticity of mouse renal collecting duct in response to potassium depletion. Physiol Genomics. 2004;19:61-73 pubmed..Finally, comparison of mouse and human OMCD transcriptomes allowed us to address the question of the relevance of the mouse as a model for human physiology and pathophysiology. ..
- Girardot F, Monnier V, Tricoire H. Genome wide analysis of common and specific stress responses in adult drosophila melanogaster. BMC Genomics. 2004;5:74 pubmed..According to our functional analysis, a large part of the genome may play a role in protective mechanisms against oxidative stress in Drosophila. ..
- Haumaitre C, Barbacci E, Jenny M, Ott M, Gradwohl G, Cereghini S. Lack of TCF2/vHNF1 in mice leads to pancreas agenesis. Proc Natl Acad Sci U S A. 2005;102:1490-5 pubmed..This study provides further insights into early molecular events controlling pancreas development and may contribute to the development of cell-replacement strategies for diabetes. ..
- Cuilliere Dartigues P, El Bchiri J, Krimi A, Buhard O, Fontanges P, Flejou J, et al. TCF-4 isoforms absent in TCF-4 mutated MSI-H colorectal cancer cells colocalize with nuclear CtBP and repress TCF-4-mediated transcription. Oncogene. 2006;25:4441-8 pubmed..They also suggest a role for TCF-4 frameshift mutation during MSI-H colorectal tumour progression, by regulating the relative proportion of the different TCF-4 isoforms. ..
- Clement N, Glorian M, Raymondjean M, Andreani M, Limon I. PGE2 amplifies the effects of IL-1beta on vascular smooth muscle cell de-differentiation: a consequence of the versatility of PGE2 receptors 3 due to the emerging expression of adenylyl cyclase 8. J Cell Physiol. 2006;208:495-505 pubmed..Using real time PCR, pharmacological tools and small interfering RNA (siRNA), we demonstrated that the different integration of PGE2 signals depends on the upregulation of calcium/calmodulin stimulable adenylyl cyclase 8. ..
- Bergeron J, Clappier E, Radford I, Buzyn A, Millien C, Soler G, et al. Prognostic and oncogenic relevance of TLX1/HOX11 expression level in T-ALLs. Blood. 2007;110:2324-30 pubmed..We propose that TLX1(+) T-ALLs be defined as cases expressing TLX1/ABL ratios greater than 1 and/or demonstrating TLX1 rearrangement. Therapeutic modification should be considered for those patients. ..
- Bristeau Leprince A, Mateo V, Lim A, Magerus Chatinet A, Solary E, Fischer A, et al. Human TCR alpha/beta+ CD4-CD8- double-negative T cells in patients with autoimmune lymphoproliferative syndrome express restricted Vbeta TCR diversity and are clonally related to CD8+ T cells. J Immunol. 2008;181:440-8 pubmed..CDR3 sequencing of matching clonotypes revealed a significant sharing of CDR3 sequences from selected Vbeta-Jbeta transcripts between DN and CD8+ T cells. Altogether, these data strongly argue for a CD8 origin of DN T cells in ALPS. ..
- Dawid A, Cayrol B, Isambert H. RNA synthetic biology inspired from bacteria: construction of transcription attenuators under antisense regulation. Phys Biol. 2009;6:025007 pubmed publisher..Overall, this suggests that direct coupling among synthesis, folding and regulation of RNAs may have enabled the early emergence of autonomous RNA-based regulation networks in absence of both DNA and protein partners. ..
- De The H, Vivanco Ruiz M, Tiollais P, Stunnenberg H, Dejean A. Identification of a retinoic acid responsive element in the retinoic acid receptor beta gene. Nature. 1990;343:177-80 pubmed..Both alpha and beta receptors enhance retinoic acid response in CV1 cells, indicating that they can both act through the same DNA sequence. ..
- McAllister A, Tangy F, Aubert C, Brahic M. Molecular cloning of the complete genome of Theiler's virus, strain DA, and production of infectious transcripts. Microb Pathog. 1989;7:381-8 pubmed..At this stage no RNA or antigens were found in neurons. Therefore the phenotype of R1-DA was indistinguishable from that of genuine DA Theiler's virus. ..
- Moreau Gachelin F, Ray D, Mattei M, Tambourin P, Tavitian A. The putative oncogene Spi-1: murine chromosomal localization and transcriptional activation in murine acute erythroleukemias. Oncogene. 1989;4:1449-56 pubmed..Proviruses always integrate outside, upstream and in the opposite orientation of the protein-encoding domain. This suggests that SFFV integration activates the expression of Spi-2 gene that may contribute to the erythroleukemic process. ..
- Lamande N, Mazo A, Lucas M, Montarras D, Pinset C, Gros F, et al. Murine muscle-specific enolase: cDNA cloning, sequence, and developmental expression. Proc Natl Acad Sci U S A. 1989;86:4445-9 pubmed
- Martin A, Escriou N, Chao S, Girard M, Lemon S, Wychowski C. Identification and site-directed mutagenesis of the primary (2A/2B) cleavage site of the hepatitis A virus polyprotein: functional impact on the infectivity of HAV RNA transcripts. Virology. 1995;213:213-22 pubmed..Arg substitution abolished cleavage and was lethal to HAV replication. In addition to identifying the site of the primary HAV polyprotein cleavage, these results shed light on the in vivo specificities of the HAV 3C protease. ..
- Delahodde A, Delaveau T, Jacq C. Positive autoregulation of the yeast transcription factor Pdr3p, which is involved in control of drug resistance. Mol Cell Biol. 1995;15:4043-51 pubmed..Finally, we provide evidence in the absence of PDR1 for a PDR3-controlled transcriptional induction of the drug pump by cycloheximide and propose a model for the mechanism governing the transcriptional autoregulation of Pdr3p...
- Traiffort E, Vizuete M, Tardivel Lacombe J, Souil E, Schwartz J, Ruat M. The guinea pig histamine H2 receptor: gene cloning, tissue expression and chromosomal localization of its human counterpart. Biochem Biophys Res Commun. 1995;211:570-7 pubmed..In addition, using Southern analysis of a chromosome mapping panel constructed from human x hamster hybridomas, we assigned the H2 receptor gene to human chromosome 5. ..
- Henglein B, Chenivesse X, Wang J, Eick D, Brechot C. Structure and cell cycle-regulated transcription of the human cyclin A gene. Proc Natl Acad Sci U S A. 1994;91:5490-4 pubmed..Cell cycle regulation of the cyclin A gene promoter is mediated by sequences extending from -79 to +100 relative to the predominant transcription start site. It does not require the presence of a functional retinoblastoma protein. ..
- Chassin D, Laurent A, Janneau J, Berger R, Bellet D. Cloning of a new member of the insulin gene superfamily (INSL4) expressed in human placenta. Genomics. 1995;29:465-70 pubmed..By in situ hybridization, the INSL4 gene was assigned to band p24 of the short arm of chromosome 9. RT-PCR analysis of EPIL tissue distribution revealed that its transcripts are expressed in the placenta and uterus. ..
- Taha M, Giorgini D, Nassif X. The pilA regulatory gene modulates the pilus-mediated adhesion of Neisseria meningitidis by controlling the transcription of pilC1. Mol Microbiol. 1996;19:1073-84 pubmed..Thus, in addition to phase variation, a more co-ordinate and responsive system may allow a fine adaptation of adhesiveness of meningococci to various environmental signals...
- Cruz Ramos H, Boursier L, Moszer I, Kunst F, Danchin A, Glaser P. Anaerobic transcription activation in Bacillus subtilis: identification of distinct FNR-dependent and -independent regulatory mechanisms. EMBO J. 1995;14:5984-94 pubmed..Thus induction of genes involved in anaerobic respiration requires in B.subtilis at least two levels of regulation: activation of fnr transcription and activation of FNR to induce transcription of FNR-dependent promoters. ..
- Hajnsdorf E, Braun F, Haugel Nielsen J, Le Derout J, Regnier P. Multiple degradation pathways of the rpsO mRNA of Escherichia coli. RNase E interacts with the 5' and 3' extremities of the primary transcript. Biochimie. 1996;78:416-24 pubmed..Looping of the rpsO mRNA might explain how RNase E bound at the 5' end can cleave at a site located just upstream the hairpin of the transcription terminator. ..
- Brechot J, Hurbain I, Fajac A, Daty N, Bernaudin J. Different pattern of MRP localization in ciliated and basal cells from human bronchial epithelium. J Histochem Cytochem. 1998;46:513-7 pubmed..In conclusion, the different patterns of localization suggest specific roles for MRP in basal and ciliated cells...
- Bertolotto C, Abbe P, Hemesath T, Bille K, Fisher D, Ortonne J, et al. Microphthalmia gene product as a signal transducer in cAMP-induced differentiation of melanocytes. J Cell Biol. 1998;142:827-35 pubmed
- Ozon S, El Mestikawy S, Sobel A. Differential, regional, and cellular expression of the stathmin family transcripts in the adult rat brain. J Neurosci Res. 1999;56:553-64 pubmed..Altogether, our results suggest distinct roles for each member of the stathmin-related phosphoprotein family, in regard to their specific regional and cellular localization in the rat brain. ..
- Presecan Siedel E, Galinier A, Longin R, Deutscher J, Danchin A, Glaser P, et al. Catabolite regulation of the pta gene as part of carbon flow pathways in Bacillus subtilis. J Bacteriol. 1999;181:6889-97 pubmed..In addition to CcpA, carbon catabolite activation of the pta gene therefore requires at least two other cofactors, FBP and either HPr or Crh, phosphorylated at Ser-46 by the ATP-dependent Hpr kinase. ..
- Goffin V, Binart N, Clement Lacroix P, Bouchard B, Bole Feysot C, Edery M, et al. From the molecular biology of prolactin and its receptor to the lessons learned from knockout mice models. Genet Anal. 1999;15:189-201 pubmed..The development of genetic models provides new opportunities to understand how PRL can participate to the development of pathologies throughout life, as for example the initiation and progression of breast cancer. ..
- Klochendler Yeivin A, Fiette L, Barra J, Muchardt C, Babinet C, Yaniv M. The murine SNF5/INI1 chromatin remodeling factor is essential for embryonic development and tumor suppression. EMBO Rep. 2000;1:500-6 pubmed..Furthermore, heterozygous mice develop nervous system and soft tissue sarcomas. In these tumors the wild-type allele was lost, providing further evidence that SNF5 functions as a tumor suppressor gene in certain cell types. ..
- Cheret C, Doyen A, Yaniv M, Pontoglio M. Hepatocyte nuclear factor 1 alpha controls renal expression of the Npt1-Npt4 anionic transporter locus. J Mol Biol. 2002;322:929-41 pubmed..Transient transfection experiments confirmed that HNF1alpha directly transactivates the Npt1 promoter and that the HSS3 region contributes to this activation. ..
- Desbois Mouthon C, Blivet Van Eggelpoël M, Beurel E, Boissan M, Delelo R, Cadoret A, et al. Dysregulation of glycogen synthase kinase-3beta signaling in hepatocellular carcinoma cells. Hepatology. 2002;36:1528-36 pubmed..Persistent phosphorylation of GSK-3beta could be critical for regulation of glycogen metabolism and cell growth in hepatoma cells. ..
- Angelier N, Tramier M, Louvet E, Coppey Moisan M, Savino T, De Mey J, et al. Tracking the interactions of rRNA processing proteins during nucleolar assembly in living cells. Mol Biol Cell. 2005;16:2862-71 pubmed..Interestingly interactions between such proteins also occur in PNBs but not at the chromosome periphery. The dynamics of these interactions suggests that PNBs are preassembly platforms for rRNA processing complexes. ..
- Carbone A, Madden R. Insights on the evolution of metabolic networks of unicellular translationally biased organisms from transcriptomic data and sequence analysis. J Mol Evol. 2005;61:456-69 pubmed
- Peignon G, Thenet S, Schreider C, Fouquet S, Ribeiro A, Dussaulx E, et al. E-cadherin-dependent transcriptional control of apolipoprotein A-IV gene expression in intestinal epithelial cells: a role for the hepatic nuclear factor 4. J Biol Chem. 2006;281:3560-8 pubmed..Altogether, our results suggest that E-cadherin controls enterocyte-specific expression of genes, such as the apoA-IV gene, through the control of hepatic nuclear factor 4alpha nuclear abundance. ..
- Oberto J, Nabti S, Jooste V, Mignot H, Rouviere Yaniv J. The HU regulon is composed of genes responding to anaerobiosis, acid stress, high osmolarity and SOS induction. PLoS ONE. 2009;4:e4367 pubmed publisher..The uniform chromosomal distribution of the many operons regulated by HU strongly suggests that the transcriptional and nucleoid architectural functions of HU constitute two aspects of a unique protein-DNA interaction mechanism. ..
- Gruel N, Lucchesi C, Raynal V, Rodrigues M, Pierron G, Goudefroye R, et al. Lobular invasive carcinoma of the breast is a molecular entity distinct from luminal invasive ductal carcinoma. Eur J Cancer. 2010;46:2399-407 pubmed publisher..These molecular specificities should help with the identification of new therapeutic targets for ILC patients. ..
- Marie I, Hovanessian A. The 69-kDa 2-5A synthetase is composed of two homologous and adjacent functional domains. J Biol Chem. 1992;267:9933-9 pubmed
- Rey Campos J, Chouard T, Yaniv M, Cereghini S. vHNF1 is a homeoprotein that activates transcription and forms heterodimers with HNF1. EMBO J. 1991;10:1445-57 pubmed..Our results raise the possibility that heterodimerization between homeoproteins could be a common phenomenon in higher eukaryotes, which may have implications in the regulatory network sustained between these factors. ..
- Monnot C, Weber V, Stinnakre J, Bihoreau C, Teutsch B, Corvol P, et al. Cloning and functional characterization of a novel mas-related gene, modulating intracellular angiotensin II actions. Mol Endocrinol. 1991;5:1477-87 pubmed
- Vidal Ingigliardi D, Raibaud O. Three adjacent binding sites for cAMP receptor protein are involved in the activation of the divergent malEp-malKp promoters. Proc Natl Acad Sci U S A. 1991;88:229-33 pubmed..The participation of several adjacent bound CRP molecules in the activation of a promoter is an unprecedented observation and might involve molecular mechanisms quite different from those used in the other CRP-controlled promoters. ..
- Lyons G, Buckingham M, Mannherz H. alpha-Actin proteins and gene transcripts are colocalized in embryonic mouse muscle. Development. 1991;111:451-4 pubmed..In cardiac muscle, alpha-actin transcripts and proteins are abundantly expressed as soon as a cardiac tube forms. ..
- Montarras D, Chelly J, Bober E, Arnold H, Ott M, Gros F, et al. Developmental patterns in the expression of Myf5, MyoD, myogenin, and MRF4 during myogenesis. New Biol. 1991;3:592-600 pubmed..Temporal and phenotypic differences related to the expression of Myf5, MyoD, Myogenin, and MRF4 suggest that these factors fulfil distinct roles in the control of myogenesis. ..
- Chelly J, Gilgenkrantz H, Lambert M, Hamard G, Chafey P, Recan D, et al. Effect of dystrophin gene deletions on mRNA levels and processing in Duchenne and Becker muscular dystrophies. Cell. 1990;63:1239-48 pubmed..In two BMD patients with out-of-frame deletions, the presence of minor in-frame alternatively spliced mRNA species is congruent with the observed truncated dystrophin and the mild phenotype. ..
- Evers S, Courvalin P. Regulation of VanB-type vancomycin resistance gene expression by the VanS(B)-VanR (B) two-component regulatory system in Enterococcus faecalis V583. J Bacteriol. 1996;178:1302-9 pubmed..Vancomycin, but not teicoplanin, was an inducer, which explains teicoplanin susceptibility of VanB-type enterococci...
- Simmler M, Cunningham D, Clerc P, Vermat T, Caudron B, Cruaud C, et al. A 94 kb genomic sequence 3' to the murine Xist gene reveals an AT rich region containing a new testis specific gene Tsx. Hum Mol Genet. 1996;5:1713-26 pubmed..The mouse and rat Tsx sequences are highly divergent, suggesting that part of the X inactivation centre, including both Xist and Tsx are subject to relatively weak evolutionary constraints. ..
- Cecchi C, Biasotto M, Tosi M, Avner P. The mottled mouse as a model for human Menkes disease: identification of mutations in the Atp7a gene. Hum Mol Genet. 1997;6:425-33 pubmed
- Kaminski P, Elmerich C. The control of Azorhizobium caulinodans nifA expression by oxygen, ammonia and by the HF-I-like protein, NrfA. Mol Microbiol. 1998;28:603-13 pubmed..NrfA also restores the defect in rpoS translation to an Escherichia coli hfq mutant, indicating that HF-I and NrfA have similar activities in both A. caulinodans and E. coli. ..
- Magnet S, Courvalin P, Lambert T. Activation of the cryptic aac(6')-Iy aminoglycoside resistance gene of Salmonella by a chromosomal deletion generating a transcriptional fusion. J Bacteriol. 1999;181:6650-5 pubmed..This genomic environment suggests a role in the catabolism of a specific sugar for AAC(6')-Iy in Salmonella...
- Di Santo J, Radtke F, Rodewald H. To be or not to be a pro-T?. Curr Opin Immunol. 2000;12:159-65 pubmed
- El Bissati K, Kirilovsky D. Regulation of psbA and psaE expression by light quality in Synechocystis species PCC 6803. A redox control mechanism. Plant Physiol. 2001;125:1988-2000 pubmed..Its reduction induces accumulation of psaE transcripts, and its oxidation induces accumulation of psbA mRNAs. ..
- Torres Padilla M, Fougère Deschatrette C, Weiss M. Expression of HNF4alpha isoforms in mouse liver development is regulated by sequential promoter usage and constitutive 3' end splicing. Mech Dev. 2001;109:183-93 pubmed
- Sirri V, Hernandez Verdun D, Roussel P. Cyclin-dependent kinases govern formation and maintenance of the nucleolus. J Cell Biol. 2002;156:969-81 pubmed..Thus, we propose that the mechanisms governing both formation and maintenance of functional nucleoli involve CDK activities and couple the cell cycle to ribosome biogenesis. ..
- Guissouma H, Dupré S, Becker N, Jeannin E, Seugnet I, Desvergne B, et al. Feedback on hypothalamic TRH transcription is dependent on thyroid hormone receptor N terminus. Mol Endocrinol. 2002;16:1652-66 pubmed..Thus N-terminal sequences specify TR T(3)-dependent repression of TRH transcription but not DNA recognition, emphasizing as yet unknown neuron-specific contributions to protein-promoter interactions in vivo. ..
- Bensaad K, Le Bras M, Unsal K, Strano S, Blandino G, Tominaga O, et al. Change of conformation of the DNA-binding domain of p53 is the only key element for binding of and interference with p73. J Biol Chem. 2003;278:10546-55 pubmed..These results reinforce the notion that mutant p53 with a conformational change can act as a down-regulator of the p73 pathway in human cancer and could confer a selective advantage to the tumor. ..
- Biville F, Oshima T, Mori H, Kawagoe Y, Bouvet O, Rager M, et al. Escherichia coli response to exogenous pyrophosphate and analogs. J Mol Microbiol Biotechnol. 2003;5:37-45 pubmed..The transcriptome data also indicated that processes other than iron uptake might be involved in the cellular response to exogenous pyrophosphate or methylenediphosphonic acid. ..
- Truchet S, Chebrout M, Djediat C, Wietzerbin J, Debey P. Presence of permanently activated signal transducers and activators of transcription in nuclear interchromatin granules of unstimulated mouse oocytes and preimplantation embryos. Biol Reprod. 2004;71:1330-9 pubmed
- Manhes C, Kayser C, Bertheau P, Kelder B, Kopchick J, Kelly P, et al. Local over-expression of prolactin in differentiating mouse mammary gland induces functional defects and benign lesions, but no carcinoma. J Endocrinol. 2006;190:271-85 pubmed..This deserves further investigations on the emerging concept that autocrine PRL may have different effects on pathological development of the mammary gland depending on the differentiation state of the latter. ..
- Bahi Buisson N, Chelly J, Des Portes V. [Update on the genetics of X-linked mental retardation]. Rev Neurol (Paris). 2006;162:952-63 pubmed..Non syndromic XLMR proteins include 5 distinct classes: transmembrane receptors, small GTPases effectors or regulators, enzymes and translational regulators. ..
- Abal M, Obrador Hevia A, Janssen K, Casadome L, Menendez M, Carpentier S, et al. APC inactivation associates with abnormal mitosis completion and concomitant BUB1B/MAD2L1 up-regulation. Gastroenterology. 2007;132:2448-58 pubmed..In addition to the known function of APC during correct spindle assembly and positioning, we propose a concomitant involvement of APC in the surveillance mechanism of accurate mitosis. ..
- Benayoun B, Batista F, Auer J, Dipietromaria A, L hôte D, De Baere E, et al. Positive and negative feedback regulates the transcription factor FOXL2 in response to cell stress: evidence for a regulatory imbalance induced by disease-causing mutations. Hum Mol Genet. 2009;18:632-44 pubmed publisher..Taken together, our results establish that FOXL2 is an actor of the stress response and provide new insights into the pathogenic consequences of FOXL2 mutations. ..
- Gueriri I, Bay S, Dubrac S, Cyncynatus C, Msadek T. The Pta-AckA pathway controlling acetyl phosphate levels and the phosphorylation state of the DegU orphan response regulator both play a role in regulating Listeria monocytogenes motility and chemotaxis. Mol Microbiol. 2008;70:1342-57 pubmed publisher..Our findings suggest that phosphorylation by acetyl phosphate could play an important role in modulating DegU activity in vivo, linking its phosphorylation state to the metabolic status of L. monocytogenes. ..
- Proux F, Dreyfus M. Construction and characterization of E. coli K12 strains in which the transcription of selected genes is desynchronized from translation. Methods Enzymol. 2008;447:243-58 pubmed publisher..Protocols in use in this laboratory for RNA extraction, Northern blotting, and beta-galactosidase assay are described and critically discussed. ..
- Toka I, Planchais S, Cabassa C, Justin A, De Vos D, Richard L, et al. Mutations in the hyperosmotic stress-responsive mitochondrial BASIC AMINO ACID CARRIER2 enhance proline accumulation in Arabidopsis. Plant Physiol. 2010;152:1851-62 pubmed publisher..Our data suggest that BAC2 is a hyperosmotic stress-inducible transporter of basic amino acids that contributes to proline accumulation in response to hyperosmotic stress in Arabidopsis. ..
- Putzer H, Gendron N, Grunberg Manago M. Co-ordinate expression of the two threonyl-tRNA synthetase genes in Bacillus subtilis: control by transcriptional antitermination involving a conserved regulatory sequence. EMBO J. 1992;11:3117-27 pubmed..e. the consensus sequence preceding a terminator structure, are found in the leader regions of most aminoacyl-tRNA synthetase genes of Gram-positive bacteria. This suggests that they are regulated by a common mechanism. ..
- Gautron S, dos Santos G, Pinto Henrique D, Koulakoff A, Gros F, Berwald Netter Y. The glial voltage-gated sodium channel: cell- and tissue-specific mRNA expression. Proc Natl Acad Sci U S A. 1992;89:7272-6 pubmed..Its level varies according to the tissue and is developmentally regulated. The sequence and expression data concur in designating Na-G as an distinct type of Na channel, presumably with low sensitivity to tetrodotoxin. ..
- Lesage P, Chiaruttini C, Graffe M, Dondon J, Milet M, Springer M. Messenger RNA secondary structure and translational coupling in the Escherichia coli operon encoding translation initiation factor IF3 and the ribosomal proteins, L35 and L20. J Mol Biol. 1992;228:366-86 pubmed
- Ozden S, Aubert C, Gonzalez Dunia D, Brahic M. In situ analysis of proteolipid protein gene transcripts during persistent Theiler's virus infection. J Histochem Cytochem. 1991;39:1305-9 pubmed..Our data indicate that viral infection of oligodendrocytes reduces the level of PLP mRNA by about 80%. ..
- Coen D. P element regulatory products enhance zeste repression of a P[white duplicated] transgene in Drosophila melanogaster. Genetics. 1990;126:949-60 pubmed..3]19DE in any backgrounds. P repression acts to reduce the amount of the major white transcript. This suggests that P regulatory products may act through cis-interactions at a distance of over 3 kb. ..
- Hazan U, Thomas D, Alcami J, Bachelerie F, Israel N, Yssel H, et al. Stimulation of a human T-cell clone with anti-CD3 or tumor necrosis factor induces NF-kappa B translocation but not human immunodeficiency virus 1 enhancer-dependent transcription. Proc Natl Acad Sci U S A. 1990;87:7861-5 pubmed..Furthermore, our results suggest that events linked to T-cell activation, in addition to NF-kappa B translocation per se, induce functional interactions of the NF-kappa B complex with the HIV enhancer. ..
- Moreau Gachelin F, Ray D, De Both N, van der Feltz M, Tambourin P, Tavitian A. Spi-1 oncogene activation in Rauscher and Friend murine virus-induced acute erythroleukemias. Leukemia. 1990;4:20-3 pubmed..These results indicate that Spi-1 gene activation is a general feature in the malignant proerythroblastic transformation which occurs in mice infected with Friend and Rauscher viruses. ..
- Yanicostas C, Vincent A, Lepesant J. Transcriptional and posttranscriptional regulation contributes to the sex-regulated expression of two sequence-related genes at the janus locus of Drosophila melanogaster. Mol Cell Biol. 1989;9:2526-35 pubmed..The janA gene displayed a much more complex expression; one of the major mRNAs was found in both sexes and at all stages, whereas the two other janA transcripts were expressed only in males. ..
- Plumbridge J. Sequence of the nagBACD operon in Escherichia coli K12 and pattern of transcription within the nag regulon. Mol Microbiol. 1989;3:505-15 pubmed..A second promoter producing nagD-specific transcripts has been mapped just in front of the nagD gene...
- Colin Y, Le Van Kim C, Tsapis A, Clerget M, d Auriol L, London J, et al. Human erythrocyte glycophorin C. Gene structure and rearrangement in genetic variants. J Biol Chem. 1989;264:3773-80 pubmed..From these observations we suggest that the Ge-2,-3 and Ge-2,+3 genes might represent the two allelic forms of a unique ancestral form of the GPC gene, following successive internal duplication and deletion events. ..
- Antoniewski C, Laval M, Dahan A, Lepesant J. The ecdysone response enhancer of the Fbp1 gene of Drosophila melanogaster is a direct target for the EcR/USP nuclear receptor. Mol Cell Biol. 1994;14:4465-74 pubmed..These results provide strong evidence for a direct role of the EcR/USP heterodimer in driving gene expression in response to changes of the ecdysteroid titer during Drosophila larval development. ..
- Beaumont C, Seyhan A, Yachou A, Grandchamp B, Jones R. Mouse ferritin H subunit gene. Functional analysis of the promoter and identification of an upstream regulatory element active in erythroid cells. J Biol Chem. 1994;269:20281-8 pubmed..Thus, nuclear factors that mediate inducibility of the ferritin enhancer remain to be identified. ..
- Vanet A, Plumbridge J, Alix J. Cotranscription of two genes necessary for ribosomal protein L11 methylation (prmA) and pantothenate transport (panF) in Escherichia coli K-12. J Bacteriol. 1993;175:7178-88 pubmed..Although no promoter activity was detected immediately upstream of prmA, S1 mapping detected 5' ends of mRNA in this region, implying that some mRNA processing occurs within the bicistronic panF-prmA mRNA. ..