Experts and Doctors on gene expression profiling in Paris, Île de France, France

Summary

Locale: Paris, Île de France, France
Topic: gene expression profiling

Top Publications

  1. Cheval L, Duong Van Huyen J, Bruneval P, Verbavatz J, Elalouf J, Doucet A. Plasticity of mouse renal collecting duct in response to potassium depletion. Physiol Genomics. 2004;19:61-73 pubmed
    ..Finally, comparison of mouse and human OMCD transcriptomes allowed us to address the question of the relevance of the mouse as a model for human physiology and pathophysiology. ..
  2. Cairo S, Wang Y, de Reynies A, Duroure K, Dahan J, Redon M, et al. Stem cell-like micro-RNA signature driven by Myc in aggressive liver cancer. Proc Natl Acad Sci U S A. 2010;107:20471-6 pubmed publisher
    ..Our data argue that Myc-driven reprogramming of miR expression patterns contributes to the aggressive phenotype of liver tumors originating from hepatic progenitor cells. ..
  3. Ramgolam K, Lauriol J, Lalou C, Lauden L, Michel L, de la Grange P, et al. Melanoma spheroids grown under neural crest cell conditions are highly plastic migratory/invasive tumor cells endowed with immunomodulator function. PLoS ONE. 2011;6:e18784 pubmed publisher
    ..Therefore, it could be constructive to investigate melanoma aggressiveness, relevant to patients and clinical transferability. ..
  4. Favier J, Igaz P, Burnichon N, Amar L, Libe R, Badoual C, et al. Rationale for anti-angiogenic therapy in pheochromocytoma and paraganglioma. Endocr Pathol. 2012;23:34-42 pubmed publisher
    ..Our results suggest that there is a strong rationale for anti-VEGF-based therapeutic strategies in malignant pheochromocytomas and paragangliomas, in particular in those associated with mutations in the SDHB gene. ..
  5. Ho J, Chapeaublanc E, Kirkwood L, Nicolle R, Benhamou S, Lebret T, et al. Deregulation of Rab and Rab effector genes in bladder cancer. PLoS ONE. 2012;7:e39469 pubmed publisher
    ..This approach is applicable to other group of genes and types of cancer. ..
  6. Antherieu S, Le Guillou D, Coulouarn C, Begriche K, Trak Smayra V, Martinais S, et al. Chronic exposure to low doses of pharmaceuticals disturbs the hepatic expression of circadian genes in lean and obese mice. Toxicol Appl Pharmacol. 2014;276:63-72 pubmed publisher
    ..g. acetaminophen, carbamazepine, ibuprofen) our data could be relevant in environmental toxicology, especially for obese individuals exposed to these contaminants. ..
  7. Assie G, Letouze E, Fassnacht M, Jouinot A, Luscap W, Barreau O, et al. Integrated genomic characterization of adrenocortical carcinoma. Nat Genet. 2014;46:607-12 pubmed publisher
    ..Thus, aggressive and indolent ACCs correspond to two distinct molecular entities driven by different oncogenic alterations...
  8. Breuiller Fouche M, Germain G. Gene and protein expression in the myometrium in pregnancy and labor. Reproduction. 2006;131:837-50 pubmed
    ..These studies also represent an indicative step that will have to be paralleled, in the future, with the results of the systematic proteomic analysis of the myometrium. ..
  9. Cheval L, Pierrat F, Dossat C, Genete M, Imbert Teboul M, Duong Van Huyen J, et al. Atlas of gene expression in the mouse kidney: new features of glomerular parietal cells. Physiol Genomics. 2011;43:161-73 pubmed publisher
    ..Finally, functional annotation of glomerulus-specific transcripts suggested a high proliferation activity of glomerular cells. Immunolabeling for PCNA confirmed a high percentage of proliferating cells in the glomerulus parietal sheet. ..

More Information

Publications187 found, 100 shown here

  1. Mongiat Artus P, Miquel C, van der Aa M, Buhard O, Hamelin R, Soliman H, et al. Microsatellite instability and mutation analysis of candidate genes in urothelial cell carcinomas of upper urinary tract. Oncogene. 2006;25:2113-8 pubmed
    ..In conclusion, MSI UUC represent a small proportion of UUC in which BAX and MRE11 mutations are frequent and may play a role early in UUC tumorigenesis. ..
  2. Bredoux R, Corvazier E, Dally S, Chaabane C, Bobe R, Raies A, et al. Human platelet Ca2+-ATPases: new markers of cell differentiation as illustrated in idiopathic scoliosis. Platelets. 2006;17:421-33 pubmed
    ..A systemic defect in cell differentiation involving caspase-3 can be proposed as a novel mechanism in the etiopathogenesis of the most frequent type of AIS. *R. Bredoux and E. Corvazier contributed equally to this work. ..
  3. Saadoun D, Bieche I, Authier F, Laurendeau I, Jambou F, Piette J, et al. Role of matrix metalloproteinases, proinflammatory cytokines, and oxidative stress-derived molecules in hepatitis C virus-associated mixed cryoglobulinemia vasculitis neuropathy. Arthritis Rheum. 2007;56:1315-24 pubmed
    ..This comprehensive molecular study of HCV-MC vasculitis provides strong evidence that MMPs, proinflammatory cytokines, and oxidative stress-derived molecules have a role in the pathogenesis of HCV-MC vasculitis neuropathy. ..
  4. Ducray F, Idbaih A, de Reynies A, Bieche I, Thillet J, Mokhtari K, et al. Anaplastic oligodendrogliomas with 1p19q codeletion have a proneural gene expression profile. Mol Cancer. 2008;7:41 pubmed publisher
  5. Berthet N, Reinhardt A, Leclercq I, van Ooyen S, Batejat C, Dickinson P, et al. Phi29 polymerase based random amplification of viral RNA as an alternative to random RT-PCR. BMC Mol Biol. 2008;9:77 pubmed publisher
    ..We adapted the QuantiTect Whole Transcriptome Kit (Qiagen) to our purposes and designated the method as Whole Transcriptome Amplification (WTA)...
  6. Bertherat J, Bertagna X. Pathogenesis of adrenocortical cancer. Best Pract Res Clin Endocrinol Metab. 2009;23:261-71 pubmed publisher
  7. Jung A, Briolat J, Millon R, de Reyniès A, Rickman D, Thomas E, et al. Biological and clinical relevance of transcriptionally active human papillomavirus (HPV) infection in oropharynx squamous cell carcinoma. Int J Cancer. 2010;126:1882-1894 pubmed publisher
  8. Schibler L, Gibbs L, Benoist Lasselin C, Decraene C, Martinovic J, Loget P, et al. New insight on FGFR3-related chondrodysplasias molecular physiopathology revealed by human chondrocyte gene expression profiling. PLoS ONE. 2009;4:e7633 pubmed publisher
    ..These results also suggest that many signaling pathways may be directly or indirectly altered by FGFR3 and confirm the crucial role of FGFR3 in the control of growth plate development. ..
  9. Weiswald L, Guinebretiere J, Richon S, Bellet D, Saubamea B, Dangles Marie V. In situ protein expression in tumour spheres: development of an immunostaining protocol for confocal microscopy. BMC Cancer. 2010;10:106 pubmed publisher
    ..It should prove useful to study rare events like CSCs within tumour spheres. ..
  10. Fabre V, Massart R, Rachalski A, Jennings K, Brass A, Sharp T, et al. Differential gene expression in mutant mice overexpressing or deficient in the serotonin transporter: a focus on urocortin 1. Eur Neuropsychopharmacol. 2011;21:33-44 pubmed publisher
    ..Thus, 5-HTT expression correlates with that of urocortin 1, suggesting that this peptide can be involved in the behavioral changes observed in 5-HTT mutant mice. ..
  11. Firon A, Tazi A, Da Cunha V, Brinster S, Sauvage E, Dramsi S, et al. The Abi-domain protein Abx1 interacts with the CovS histidine kinase to control virulence gene expression in group B Streptococcus. PLoS Pathog. 2013;9:e1003179 pubmed publisher
    ..In conclusion, our study reports a regulatory function for Abx1, a member of a large protein family with a characteristic Abi-domain, which forms a signaling complex with the histidine kinase CovS in GBS...
  12. Michot C, Mamoune A, Vamecq J, Viou M, Hsieh L, Testet E, et al. Combination of lipid metabolism alterations and their sensitivity to inflammatory cytokines in human lipin-1-deficient myoblasts. Biochim Biophys Acta. 2013;1832:2103-14 pubmed publisher
    ..Our data suggest that the pathogenic mechanism of rhabdomyolysis in lipin-1-deficient patients combines the predisposing constitutive impairment of lipid metabolism and its exacerbation by pro-inflammatory cytokines. ..
  13. Ducat A, Doridot L, Calicchio R, Méhats C, Vilotte J, Castille J, et al. Endothelial cell dysfunction and cardiac hypertrophy in the STOX1 model of preeclampsia. Sci Rep. 2016;6:19196 pubmed publisher
    ..The STOX1 mice could help to better understand the endothelial dysfunction in the context of preeclampsia, and guide the search for efficient therapies able to protect the maternal endothelium during the disease and its aftermath. ..
  14. Jacobsen M, Mentzel C, Olesen A, Huby T, Jørgensen C, Barrès R, et al. Altered Methylation Profile of Lymphocytes Is Concordant with Perturbation of Lipids Metabolism and Inflammatory Response in Obesity. J Diabetes Res. 2016;2016:8539057 pubmed publisher
  15. Mazaud S, Oreal E, Guigon C, Carre Eusebe D, Magre S. Lhx9 expression during gonadal morphogenesis as related to the state of cell differentiation. Gene Expr Patterns. 2002;2:373-7 pubmed
    ..In conclusion, Lhx9 expression can be inversely correlated with the commitment into a differentiation pathway of the different categories of mesothelium-derived cells of the gonad. ..
  16. Girardot F, Monnier V, Tricoire H. Genome wide analysis of common and specific stress responses in adult drosophila melanogaster. BMC Genomics. 2004;5:74 pubmed
    ..According to our functional analysis, a large part of the genome may play a role in protective mechanisms against oxidative stress in Drosophila. ..
  17. Javelaud D, Delmas V, Moller M, Sextius P, Andre J, Menashi S, et al. Stable overexpression of Smad7 in human melanoma cells inhibits their tumorigenicity in vitro and in vivo. Oncogene. 2005;24:7624-9 pubmed
    ..These results suggest that TGF-beta production by melanoma cells not only affects the tumor environment but also directly contributes to tumor cell aggressiveness through autocrine activation of Smad signaling. ..
  18. Assie G, Auzan C, Gasc J, Baviera E, Balaton A, Elalouf J, et al. Steroidogenesis in aldosterone-producing adenoma revisited by transcriptome analysis. J Clin Endocrinol Metab. 2005;90:6638-49 pubmed
    ..Finally, other differentially expressed genes include three genes encoding unidentified proteins. This work provides an original and integrated view of the mechanisms of aldosterone production in PAL. ..
  19. Lecomte C, Andujar P, Renier A, Kheuang L, Abramowski V, Mellottee L, et al. Similar tumor suppressor gene alteration profiles in asbestos-induced murine and human mesothelioma. Cell Cycle. 2005;4:1862-9 pubmed
    ..Thus, the mouse mesothelioma model could be useful for human risk assessment, taking into account interindividual variations in genetic sensitivity to carcinogens. ..
  20. Nguyen J, Dumont J, Bauvois B. Comparative effects of interferon-gamma and all- trans retinoic acid on secreted and surface-associated matrix metalloproteinase-9 expression of human monocytes. Cell Mol Biol (Noisy-le-grand). 2006;52:51-8 pubmed
    ..Together, our data suggest the potential relevance of all-trans retinoic acid as a pharmacological tool to attenuate matrix metalloproteinase-9 secretion in pathological situations. ..
  21. Natalang O, Bischoff E, Deplaine G, Proux C, Dillies M, Sismeiro O, et al. Dynamic RNA profiling in Plasmodium falciparum synchronized blood stages exposed to lethal doses of artesunate. BMC Genomics. 2008;9:388 pubmed publisher
    ..Further work is needed to clarify which transcriptome alterations observed reflect a specific response to overcome artesunate toxicity or more general perturbations on the path to cellular death. ..
  22. Pérot G, Chibon F, Montero A, Lagarde P, De The H, Terrier P, et al. Constant p53 pathway inactivation in a large series of soft tissue sarcomas with complex genetics. Am J Pathol. 2010;177:2080-90 pubmed publisher
    ..Conversely, in TP53-altered tumors, p15 and p16 are well expressed, a feature not incompatible with an oncogenic process. ..
  23. Karaca M. In vivo functional heterogeneity among β-cells. Islets. 2010;2:124-6 pubmed publisher
    ..Here we summarize our main results on β(high) and β(low)-cell populations and discuss some of the open remaining questions. ..
  24. Chaussepied M, Janski N, Baumgartner M, Lizundia R, Jensen K, Weir W, et al. TGF-b2 induction regulates invasiveness of Theileria-transformed leukocytes and disease susceptibility. PLoS Pathog. 2010;6:e1001197 pubmed publisher
    ..We propose that a TGF-b autocrine loop confers an amoeboid-like motility on Theileria-infected leukocytes, which combines with MMP-dependent motility to drive invasiveness and virulence. ..
  25. Corpet A, de Koning L, Toedling J, Savignoni A, Berger F, Lemaître C, et al. Asf1b, the necessary Asf1 isoform for proliferation, is predictive of outcome in breast cancer. EMBO J. 2011;30:480-93 pubmed publisher
    ..We discuss the implications of these results for breast cancer diagnosis and prognosis. ..
  26. Olivier A, Sainz Perez A, Dong H, Sparwasser T, Majlessi L, Leclerc C. The adjuvant effect of TLR agonists on CD4(+) effector T cells is under the indirect control of regulatory T cells. Eur J Immunol. 2011;41:2303-13 pubmed publisher
    ..The phenotypic Treg activation observed in vivo, following TLR administration, does not result from cross-talk with conventional T cells but is rather a consequence of the interaction with other immune cell type(s). ..
  27. De Cremoux P, Valet F, Gentien D, Lehmann Che J, Scott V, Tran Perennou C, et al. Importance of pre-analytical steps for transcriptome and RT-qPCR analyses in the context of the phase II randomised multicentre trial REMAGUS02 of neoadjuvant chemotherapy in breast cancer patients. BMC Cancer. 2011;11:215 pubmed publisher
    ..More stringent criteria are needed for transcriptome analysis for clinical applications. ..
  28. Dib H, Chafey P, Clary G, Federici C, Le Gall M, Dwyer J, et al. Proteomes of umbilical vein and microvascular endothelial cells reflect distinct biological properties and influence immune recognition. Proteomics. 2012;12:2547-55 pubmed publisher
    ..The proteome profiles of HUVEC and microvascular EC differ noticeably, which reflects distinct biological properties and influence immune recognition. ..
  29. Manceau G, Letouze E, Guichard C, Didelot A, Cazes A, Corté H, et al. Recurrent inactivating mutations of ARID2 in non-small cell lung carcinoma. Int J Cancer. 2013;132:2217-21 pubmed publisher
  30. Giraud E, Lecoeur H, Soubigou G, Coppee J, Milon G, Prina E, et al. Distinct transcriptional signatures of bone marrow-derived C57BL/6 and DBA/2 dendritic leucocytes hosting live Leishmania amazonensis amastigotes. PLoS Negl Trop Dis. 2012;6:e1980 pubmed publisher
  31. Zinovyev A, Kuperstein I, Barillot E, Heyer W. Synthetic lethality between gene defects affecting a single non-essential molecular pathway with reversible steps. PLoS Comput Biol. 2013;9:e1003016 pubmed publisher
    ..These observations extend the canonical interpretation of synthetic-lethal or synthetic-sick interactions with direct implications to reconstruct molecular pathways and improve therapeutic approaches to diseases such as cancer. ..
  32. Veluchamy A, Lin X, Maumus F, Rivarola M, Bhavsar J, Creasy T, et al. Insights into the role of DNA methylation in diatoms by genome-wide profiling in Phaeodactylum tricornutum. Nat Commun. 2013;4:2091 pubmed publisher
    ..These patterns contrast with those found previously in other eukaryotes. By going beyond plants, animals and fungi, this stramenopile methylome adds significantly to our understanding of the evolution of DNA methylation in eukaryotes. ..
  33. Ragazzon B, Libe R, Assie G, Tissier F, Barreau O, Houdayer C, et al. Mass-array screening of frequent mutations in cancers reveals RB1 alterations in aggressive adrenocortical carcinomas. Eur J Endocrinol. 2014;170:385-91 pubmed publisher
    ..Parallel analysis of somatic mutations among known cancer genes allowed us to identify RB1 as a new actor in aggressive ACCs. These results suggest a prognostic significance of pRb expression loss in ACCs. ..
  34. Engert A, Balduini C, Brand A, Coiffier B, Cordonnier C, Döhner H, et al. The European Hematology Association Roadmap for European Hematology Research: a consensus document. Haematologica. 2016;101:115-208 pubmed publisher
  35. Hommais F, Krin E, Laurent Winter C, Soutourina O, Malpertuy A, Le Caer J, et al. Large-scale monitoring of pleiotropic regulation of gene expression by the prokaryotic nucleoid-associated protein, H-NS. Mol Microbiol. 2001;40:20-36 pubmed
    ..These results suggest that there is a strong relationship between the H-NS regulon and the maintenance of intracellular homeostasis. ..
  36. Biville F, Oshima T, Mori H, Kawagoe Y, Bouvet O, Rager M, et al. Escherichia coli response to exogenous pyrophosphate and analogs. J Mol Microbiol Biotechnol. 2003;5:37-45 pubmed
    ..The transcriptome data also indicated that processes other than iron uptake might be involved in the cellular response to exogenous pyrophosphate or methylenediphosphonic acid. ..
  37. Weller S, Braun M, Tan B, Rosenwald A, Cordier C, Conley M, et al. Human blood IgM "memory" B cells are circulating splenic marginal zone B cells harboring a prediversified immunoglobulin repertoire. Blood. 2004;104:3647-54 pubmed
    ..It is therefore proposed that these IgM(+)IgD(+)CD27(+) B cells provide the splenic marginal zone with a diversified and protective preimmune repertoire in charge of the responses against encapsulated bacteria. ..
  38. Laurent S, Boutouyrie P, Lacolley P. Structural and genetic bases of arterial stiffness. Hypertension. 2005;45:1050-5 pubmed
    ..These data provide strong evidence that arterial stiffness is affected by the amount and density of stiff wall material and the spatial organization of that material. ..
  39. Saadoun D, Bieche I, Maisonobe T, Asselah T, Laurendeau I, Piette J, et al. Involvement of chemokines and type 1 cytokines in the pathogenesis of hepatitis C virus-associated mixed cryoglobulinemia vasculitis neuropathy. Arthritis Rheum. 2005;52:2917-25 pubmed
    ..4 +/- 8.3 versus 5.3 +/- 3.4 for MIP-1alpha and 7.2 +/- 1.5 versus 2.5 +/- 0.9 for CXCR3). This study is the first to demonstrate a role of cellular immunity and Th1 lymphocytes in the pathogenesis of HCV-MC vasculitic nerve lesions. ..
  40. Bonay M, Boutten A, Leçon Malas V, Marchal J, Soler P, Fournier M, et al. Hepatocyte and keratinocyte growth factors and their receptors in human lung emphysema. BMC Pulm Med. 2005;5:13 pubmed
    ..Hepatocyte growth factor mRNA correlates with the severity of airflow obstruction in smokers. ..
  41. Chouquet B, Debernard S, Bozzolan F, Solvar M, Maïbèche Coisne M, Lucas P. A TRP channel is expressed in Spodoptera littoralis antennae and is potentially involved in insect olfactory transduction. Insect Mol Biol. 2009;18:213-22 pubmed publisher
    ..This work is the first step in understanding the involvement of TRPgamma in signalling pathways involved in the development and function of the insect olfactory system. ..
  42. Osorio y Fortéa J, de La Llave E, Regnault B, Coppee J, Milon G, Lang T, et al. Transcriptional signatures of BALB/c mouse macrophages housing multiplying Leishmania amazonensis amastigotes. BMC Genomics. 2009;10:119 pubmed publisher
    ..Moreover, these MPhi hosting multiplying L. amazonensis amastigotes display a transcriptional profile biased towards parasite-and host tissue-protective processes. ..
  43. Moldrich R, Dauphinot L, Laffaire J, Vitalis T, Herault Y, Beart P, et al. Proliferation deficits and gene expression dysregulation in Down's syndrome (Ts1Cje) neural progenitor cells cultured from neurospheres. J Neurosci Res. 2009;87:3143-52 pubmed publisher
    ..Interestingly, proliferation and gene expression dysregulation detected in the Ts1Cje mice did not require overexpression of the chromosome 21 genes amyloid precursor protein (App) and soluble superoxide dismutase 1 (Sod1). ..
  44. Sapriel G, Quinet M, Heijde M, Jourdren L, Tanty V, Luo G, et al. Genome-wide transcriptome analyses of silicon metabolism in Phaeodactylum tricornutum reveal the multilevel regulation of silicic acid transporters. PLoS ONE. 2009;4:e7458 pubmed publisher
    ..Analyzing at the global scale the genes networks involved in Si transport and metabolism is critical in order to elucidate Si biomineralization, and to understand diatoms contribution to biogeochemical cycles...
  45. Assie G, Guillaud Bataille M, Ragazzon B, Bertagna X, Bertherat J, Clauser E. The pathophysiology, diagnosis and prognosis of adrenocortical tumors revisited by transcriptome analyses. Trends Endocrinol Metab. 2010;21:325-34 pubmed publisher
  46. Miraoui H, Ringe J, Häupl T, Marie P. Increased EFG- and PDGFalpha-receptor signaling by mutant FGF-receptor 2 contributes to osteoblast dysfunction in Apert craniosynostosis. Hum Mol Genet. 2010;19:1678-89 pubmed publisher
  47. Cherfils Vicini J, Platonova S, Gillard M, Laurans L, Validire P, Caliandro R, et al. Triggering of TLR7 and TLR8 expressed by human lung cancer cells induces cell survival and chemoresistance. J Clin Invest. 2010;120:1285-97 pubmed publisher
  48. Ragazzon B, Libe R, Gaujoux S, Assie G, Fratticci A, Launay P, et al. Transcriptome analysis reveals that p53 and {beta}-catenin alterations occur in a group of aggressive adrenocortical cancers. Cancer Res. 2010;70:8276-81 pubmed publisher
    ..This study shows the important respective roles of p53 and ?-catenin in ACC development, delineating subgroups of ACC with different tumorigenesis and outcomes. ..
  49. Gibault L, Pérot G, Chibon F, Bonnin S, Lagarde P, Terrier P, et al. New insights in sarcoma oncogenesis: a comprehensive analysis of a large series of 160 soft tissue sarcomas with complex genomics. J Pathol. 2011;223:64-71 pubmed publisher
    ..These data suggest a very complex interplay between pathways downstream of PTEN and the WNT canonical pathway, providing new hints about SCG pathobiology and their potential therapeutic targets...
  50. Assie G, Giordano T, Bertherat J. Gene expression profiling in adrenocortical neoplasia. Mol Cell Endocrinol. 2012;351:111-7 pubmed publisher
  51. Frisan E, Vandekerckhove J, de Thonel A, Pierre Eugène C, Sternberg A, Arlet J, et al. Defective nuclear localization of Hsp70 is associated with dyserythropoiesis and GATA-1 cleavage in myelodysplastic syndromes. Blood. 2012;119:1532-42 pubmed publisher
    ..Alteration of Hsp70 cytosolic-nuclear shuttling is a major feature of MDS that favors GATA-1 cleavage and differentiation impairment, but not apoptosis, in dysplastic erythroblasts...
  52. Vaiman D, Calicchio R, Miralles F. Landscape of transcriptional deregulations in the preeclamptic placenta. PLoS ONE. 2013;8:e65498 pubmed publisher
    ..We discuss here the molecular mechanisms of action of these transcription factors and how they can be related to the placental dysfunction in the context of preeclampsia...
  53. Loza Correa M, Sahr T, Rolando M, Daniels C, Petit P, Skarina T, et al. The Legionella pneumophila kai operon is implicated in stress response and confers fitness in competitive environments. Environ Microbiol. 2014;16:359-81 pubmed publisher
    ..pneumophila KaiBC resemble Synechosystis KaiC2B2 and not circadian KaiB1C1. Thus, the L. pneumophila Kai proteins do not encode a circadian clock, but enhance stress resistance and adaption to changes in the environments. ..
  54. Lund E, Holden L, Bøvelstad H, Plancade S, Mode N, Günther C, et al. A new statistical method for curve group analysis of longitudinal gene expression data illustrated for breast cancer in the NOWAC postgenome cohort as a proof of principle. BMC Med Res Methodol. 2016;16:28 pubmed publisher
    ..When applied to a real data set it was able to discriminate between groups of genes with non-linear similar patterns before diagnosis. ..
  55. Picard F, Robin S, Lavielle M, Vaisse C, Daudin J. A statistical approach for array CGH data analysis. BMC Bioinformatics. 2005;6:27 pubmed
    ..Adaptive methods for model selection give promising results concerning the estimation of the number of altered regions on the genome. ..
  56. Mourlevat S, Debeir T, Ferrario J, Delbe J, Caruelle D, Lejeune O, et al. Pleiotrophin mediates the neurotrophic effect of cyclic AMP on dopaminergic neurons: analysis of suppression-subtracted cDNA libraries and confirmation in vitro. Exp Neurol. 2005;194:243-54 pubmed
    ..In addition, our experiments have provided evidence for a cAMP-dependent regulatory pathway leading to protease activation, and the identification of pleiotrophin as a target of this pathway. ..
  57. Barnache S, Le Scolan E, Kosmider O, Denis N, Moreau Gachelin F. Phosphatidylinositol 4-phosphatase type II is an erythropoietin-responsive gene. Oncogene. 2006;25:1420-3 pubmed
    ..This study provides first insight for a physiological role of PI-4-phosphatase II in the proerythroblast by controlling Epo responsiveness through a negative regulation of the PI3K/Akt pathway. ..
  58. Tien M, Girardin S, Regnault B, Le Bourhis L, Dillies M, Coppee J, et al. Anti-inflammatory effect of Lactobacillus casei on Shigella-infected human intestinal epithelial cells. J Immunol. 2006;176:1228-37 pubmed
    ..casei treatment. Thus, L. casei has developed a sophisticated means to maintain intestinal homeostasis through a process that involves manipulation of the ubiquitin/proteasome pathway upstream of I-kappaBalpha. ..
  59. Le Priol Y, Puthier D, Lecureuil C, Combadiere C, Debre P, Nguyen C, et al. High cytotoxic and specific migratory potencies of senescent CD8+ CD57+ cells in HIV-infected and uninfected individuals. J Immunol. 2006;177:5145-54 pubmed
    ..CD8+ CD57+ T cells from both HIV and uninfected subjects maintain effective cytotoxic potentials but are destined to migrate to nonlymphoid tissues without further cycling. ..
  60. El Bchiri J, Guilloux A, Dartigues P, Loire E, Mercier D, Buhard O, et al. Nonsense-mediated mRNA decay impacts MSI-driven carcinogenesis and anti-tumor immunity in colorectal cancers. PLoS ONE. 2008;3:e2583 pubmed publisher
  61. Jais J, Haioun C, Molina T, Rickman D, de Reynies A, Berger F, et al. The expression of 16 genes related to the cell of origin and immune response predicts survival in elderly patients with diffuse large B-cell lymphoma treated with CHOP and rituximab. Leukemia. 2008;22:1917-24 pubmed publisher
  62. Babajko S, Petit S, Fernandes I, Meary F, LeBihan J, Pibouin L, et al. Msx1 expression regulation by its own antisense RNA: consequence on tooth development and bone regeneration. Cells Tissues Organs. 2009;189:115-21 pubmed publisher
    ..In that sense, our current results suggest a clear involvement of Msx1 in alveolar bone. ..
  63. Bernard Pierrot I, Gruel N, Stransky N, Vincent Salomon A, Reyal F, Raynal V, et al. Characterization of the recurrent 8p11-12 amplicon identifies PPAPDC1B, a phosphatase protein, as a new therapeutic target in breast cancer. Cancer Res. 2008;68:7165-75 pubmed publisher
    ..PPAPDC1B may also potentiate the estrogen receptor pathway by down-regulating DUSP22. ..
  64. Chouquet B, Bozzolan F, Solvar M, Duportets L, Jacquin Joly E, Lucas P, et al. Molecular cloning and expression patterns of a putative olfactory diacylglycerol kinase from the noctuid moth Spodoptera littoralis. Insect Mol Biol. 2008;17:485-93 pubmed
    ..These data provide the first molecular characterization of a DGK potentially involved in the regulation of signalling pathways responsible for the establishment and/or the functioning of the olfactory system in Lepidoptera. ..
  65. Andreu P, Peignon G, Slomianny C, Taketo M, Colnot S, Robine S, et al. A genetic study of the role of the Wnt/beta-catenin signalling in Paneth cell differentiation. Dev Biol. 2008;324:288-96 pubmed publisher
    ..Overall, our findings show that a high level of beta-catenin activation is required to determine Paneth cell fate and that fine tuning of beta-catenin signalling is critical for correct Paneth cell lineage...
  66. Rachidi M, Delezoide A, Delabar J, Lopes C. A quantitative assessment of gene expression (QAGE) reveals differential overexpression of DOPEY2, a candidate gene for mental retardation, in Down syndrome brain regions. Int J Dev Neurosci. 2009;27:393-8 pubmed publisher
  67. Assie G, Louiset E, Sturm N, Rene Corail F, Groussin L, Bertherat J, et al. Systematic analysis of G protein-coupled receptor gene expression in adrenocorticotropin-independent macronodular adrenocortical hyperplasia identifies novel targets for pharmacological control of adrenal Cushing's syndrome. J Clin Endocrinol Metab. 2010;95:E253-62 pubmed publisher
    ..Clonidine-induced increase in basal cortisol levels was blocked by the ADRA2A antagonist yohimbine. ADRA2A is a potential target for pharmacological treatment of Cushing's syndrome linked to AIMAH. ..
  68. de Cremoux P. [Molecular prognostic and predictive markers of breast cancer treatment]. Bull Cancer. 2010;97:1297-304 pubmed publisher
  69. Courtin A, Communal L, Vilasco M, Cimino D, Mourra N, De Bortoli M, et al. Glucocorticoid receptor activity discriminates between progesterone and medroxyprogesterone acetate effects in breast cells. Breast Cancer Res Treat. 2012;131:49-63 pubmed publisher
    ..The consequences of MPA glucocorticoid potencies as well as the importance of GR in breast tissue merit a reappraisal. ..
  70. Bandiera S, Rüberg S, Girard M, Cagnard N, Hanein S, Chretien D, et al. Nuclear outsourcing of RNA interference components to human mitochondria. PLoS ONE. 2011;6:e20746 pubmed publisher
    ..Our data outline the molecular bases for a novel layer of crosstalk between nucleus and mitochondria through a specific subset of human miRNAs that we termed 'mitomiRs'. ..
  71. Mourikis P, Sambasivan R, Castel D, Rocheteau P, Bizzarro V, Tajbakhsh S. A critical requirement for notch signaling in maintenance of the quiescent skeletal muscle stem cell state. Stem Cells. 2012;30:243-52 pubmed publisher
    ..This study establishes Notch signaling pathway as the first regulator of cellular quiescence in adult muscle stem cells. ..
  72. Genin P, Lin R, Hiscott J, Civas A. Recruitment of histone deacetylase 3 to the interferon-A gene promoters attenuates interferon expression. PLoS ONE. 2012;7:e38336 pubmed publisher
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