Genomes and Genes
Experts and Doctors on cell cycle proteins in Paris, Île de France, France
Locale: Paris, Île de France, France
Topic: cell cycle proteins
Publications110 found, 100 shown here
- Wright D, Marchal C, Hoang K, Ankney J, Nguyen S, Rushing A, et al. Human T-cell leukemia virus type-1-encoded protein HBZ represses p53 function by inhibiting the acetyltransferase activity of p300/CBP and HBO1. Oncotarget. 2016;7:1687-706 pubmed publisher..This mechanism may explain how p53 activity is restricted in ATL cells that do not express Tax due to modifications of the HTLV-1 provirus, which accounts for a majority of patient samples. ..
- Johansson Ã, Eriksson N, Lindholm D, Varenhorst C, James S, SyvÃ¤nen A, et al. Genome-wide association and Mendelian randomization study of NT-proBNP in patients with acute coronary syndrome. Hum Mol Genet. 2016;25:1447-56 pubmed publisher..Due to pleotropic effects of SLC39A8, these results do not suggest that NT-proBNP levels have a direct effect on mortality in ACS patients. PLATO Clinical Trial Registration: www.clinicaltrials.gov; NCT00391872. ..
- Gavard J, Marthiens V, Monnet C, Lambert M, Mège R. N-cadherin activation substitutes for the cell contact control in cell cycle arrest and myogenic differentiation: involvement of p120 and beta-catenin. J Biol Chem. 2004;279:36795-802 pubmed..Our results demonstrate that N-cadherin adhesion may account for cell-cell contact-dependent cell cycle arrest and differentiation of myogenic cells, involving regulation through p120 and beta-catenins. ..
- Bellaiche Y, Gotta M. Heterotrimeric G proteins and regulation of size asymmetry during cell division. Curr Opin Cell Biol. 2005;17:658-63 pubmed..Interestingly, recent work in mammalian cells suggests that heterotrimeric G proteins may control spindle positioning in higher organisms during symmetric and asymmetric cell divisions. ..
- O Sullivan R, Arnoult N, Lackner D, Oganesian L, Haggblom C, Corpet A, et al. Rapid induction of alternative lengthening of telomeres by depletion of the histone chaperone ASF1. Nat Struct Mol Biol. 2014;21:167-74 pubmed publisher..The induction of ALT phenotypes as a consequence of ASF1 depletion strongly supports the hypothesis that ALT is a consequence of histone management dysfunction. ..
- Holmes A, Roseaulin L, Schurra C, Waxin H, Lambert S, Zaratiegui M, et al. Lsd1 and lsd2 control programmed replication fork pauses and imprinting in fission yeast. Cell Rep. 2012;2:1513-20 pubmed publisher..These findings reveal a role for the Lsd1/2 demethylases in controlling polar replication fork progression, imprint formation, and subsequent asymmetric cell divisions. ..
- Borck G, Zarhrate M, Bonnefont J, Munnich A, Cormier Daire V, Colleaux L. Incidence and clinical features of X-linked Cornelia de Lange syndrome due to SMC1L1 mutations. Hum Mutat. 2007;28:205-6 pubmed..If confirmed, these data may have important implications for directing mutation screening in CdLS...
- Jacquemin V, Rieunier G, Jacob S, Bellanger D, d Enghien C, Lauge A, et al. Underexpression and abnormal localization of ATM products in ataxia telangiectasia patients bearing ATM missense mutations. Eur J Hum Genet. 2012;20:305-12 pubmed publisher..This new finding highlights ATM mislocalization as a new mechanism of ATM dysfunction, which may lead to therapeutic strategies for missense mutation associated A-T...
- Delaguillaumie A, Lagaudrière Gesbert C, Popoff M, Conjeaud H. Rho GTPases link cytoskeletal rearrangements and activation processes induced via the tetraspanin CD82 in T lymphocytes. J Cell Sci. 2002;115:433-43 pubmed..This novel link between a tetraspanin and the Rho GTPase cascade could explain why tetraspanins, which are known to form heterocomplexes, are involved in cell activation, adhesion, growth and metastasis. ..
- Asnafi V, Buzyn A, Le Noir S, Baleydier F, Simon A, Beldjord K, et al. NOTCH1/FBXW7 mutation identifies a large subgroup with favorable outcome in adult T-cell acute lymphoblastic leukemia (T-ALL): a Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL) study. Blood. 2009;113:3918-24 pubmed publisher..01, respectively). These data demonstrate that NOTCH1 pathway activation by either NOTCH1 or FBXW7 mutation identifies a large group of patients with a favorable outcome that could justify individual therapeutic stratification for T-ALL. ..
- Lhuillier P, Rode B, Escalier D, Lores P, Dirami T, Bienvenu T, et al. Absence of annulus in human asthenozoospermia: case report. Hum Reprod. 2009;24:1296-303 pubmed publisher..The case we studied, so far unreported in human, confirms the involvement of Tat1 and Septin proteins in the constitution of the annulus, but also raises questions about the function of this structure in human sperm motility. ..
- Artus C, Glacial F, Ganeshamoorthy K, Ziegler N, Godet M, Guilbert T, et al. The Wnt/planar cell polarity signaling pathway contributes to the integrity of tight junctions in brain endothelial cells. J Cereb Blood Flow Metab. 2014;34:433-40 pubmed publisher..In conclusion, this study suggests that the Wnt/Par/aPKC PCP pathway, in addition to the Wnt/?-catenin canonical pathway, is a key regulator of the BBB. ..
- Ossareh Nazari B, Bonizec M, Cohen M, Dokudovskaya S, Delalande F, Schaeffer C, et al. Cdc48 and Ufd3, new partners of the ubiquitin protease Ubp3, are required for ribophagy. EMBO Rep. 2010;11:548-54 pubmed publisher..Our data favour the idea that these factors cooperate to recognize and deubiquitinate specific substrates of ribophagy before their vacuolar degradation. ..
- Karimova G, Davi M, Ladant D. The ?-lactam resistance protein Blr, a small membrane polypeptide, is a component of the Escherichia coli cell division machinery. J Bacteriol. 2012;194:5576-88 pubmed..Altogether, our results suggest that the small membrane polypeptide Blr is a novel component of the E. coli cell division apparatus involved in the stabilization of the divisome under certain stress conditions. ..
- Serre V, Rozanska A, Beinat M, Chretien D, Boddaert N, Munnich A, et al. Mutations in mitochondrial ribosomal protein MRPL12 leads to growth retardation, neurological deterioration and mitochondrial translation deficiency. Biochim Biophys Acta. 2013;1832:1304-12 pubmed publisher..Therefore, analysis of the mutated version found in the subject presented here suggests that the mammalian protein does not function in an entirely analogous manner to the eubacterial L7/L12 equivalent. ..
- Stojkovic T, Hammouda E, Richard P, Lopez de Munain A, Ruiz Martinez J, Camaño P, et al. Clinical outcome in 19 French and Spanish patients with valosin-containing protein myopathy associated with Paget's disease of bone and frontotemporal dementia. Neuromuscul Disord. 2009;19:316-23 pubmed publisher..We observed intrafamilial and interfamilial variability in terms of severity, distribution of weakness and presence or not of Paget's disease or cognitive impairment...
- Vitour D, Dabo S, Ahmadi Pour M, Vilasco M, Vidalain P, Jacob Y, et al. Polo-like kinase 1 (PLK1) regulates interferon (IFN) induction by MAVS. J Biol Chem. 2009;284:21797-809 pubmed publisher..Altogether, these data demonstrate a new function for PLK1 as a regulator of IFN induction and provide the basis for the development of inhibitors preventing the PLK1/MAVS association to sustain innate immunity. ..
- Corpet A, de Koning L, Toedling J, Savignoni A, Berger F, Lemaître C, et al. Asf1b, the necessary Asf1 isoform for proliferation, is predictive of outcome in breast cancer. EMBO J. 2011;30:480-93 pubmed publisher..We discuss the implications of these results for breast cancer diagnosis and prognosis. ..
- Burger J, Merlet J, Tavernier N, Richaudeau B, Arnold A, Ciosk R, et al. CRL2(LRR-1) E3-ligase regulates proliferation and progression through meiosis in the Caenorhabditis elegans germline. PLoS Genet. 2013;9:e1003375 pubmed publisher..Given its widespread evolutionary conservation, CUL-2 may similarly regulate germline development in other organisms as well. ..
- Houlard M, Arudchandran R, Regnier Ricard F, Germani A, Gisselbrecht S, Blank U, et al. Vav1 is a component of transcriptionally active complexes. J Exp Med. 2002;195:1115-27 pubmed..Thus, we describe a novel nuclear role for Vav1 as a component and facilitator of NFAT and NFkappaB-like transcriptional activity. ..
- Ray Gallet D, Woolfe A, Vassias I, Pellentz C, Lacoste N, Puri A, et al. Dynamics of histone H3 deposition in vivo reveal a nucleosome gap-filling mechanism for H3.3 to maintain chromatin integrity. Mol Cell. 2011;44:928-41 pubmed publisher..3, and HIRA association with Pol II ensures local H3.3 enrichment at specific sites. We discuss the importance of this H3.3 deposition as a salvage pathway to maintain chromatin integrity. ..
- Rahmani Z, Gagou M, Lefebvre C, Emre D, Karess R. Separating the spindle, checkpoint, and timer functions of BubR1. J Cell Biol. 2009;187:597-605 pubmed publisher..Timing is shorter in bubR1-KEN mad2 double mutants, yet in these flies, lacking both critical SAC components, chromosomes still segregate accurately, reconfirming that in Drosophila, reliable mitosis does not need the SAC. ..
- Drapier D, Girard Bascou J, Stern D, Wollman F. A dominant nuclear mutation in Chlamydomonas identifies a factor controlling chloroplast mRNA stability by acting on the coding region of the atpA transcript. Plant J. 2002;31:687-97 pubmed..We discuss the action of MDA1 in relation to the unusual pattern of expression of atpA that associates particularly short lived-transcripts with a very high translational efficiency. ..
- Lebrun N, Lebon S, Jeannet P, Jacquemont S, Billuart P, Bienvenu T. Early-onset encephalopathy with epilepsy associated with a novel splice site mutation in SMC1A. Am J Med Genet A. 2015;167A:3076-81 pubmed publisher..Our findings suggest that loss-of-function mutations of SMC1A may be associated with early-onset encephalopathy with epilepsy. ..
- Kos I, Patterson M, Znaidi S, Kaloriti D, da Silva Dantas A, Herrero de Dios C, et al. Mechanisms Underlying the Delayed Activation of the Cap1 Transcription Factor in Candida albicans following Combinatorial Oxidative and Cationic Stress Important for Phagocytic Potency. MBio. 2016;7:e00331 pubmed publisher..These mechanisms probably explain the potency of neutrophils, which employ multiple stresses to kill fungal pathogens. ..
- Bellanger S, Blachon S, Mechali F, Bonne Andrea C, Thierry F. High-risk but not low-risk HPV E2 proteins bind to the APC activators Cdh1 and Cdc20 and cause genomic instability. Cell Cycle. 2005;4:1608-15 pubmed publisher..The finding that high-risk, but not low-risk HPV E2 proteins, induce genomic instability, raises the intriguing possibility that E2 proteins play a role in the oncogenic potential of high-risk papillomaviruses...
- Chapgier A, Boisson Dupuis S, Jouanguy E, Vogt G, Feinberg J, Prochnicka Chalufour A, et al. Novel STAT1 alleles in otherwise healthy patients with mycobacterial disease. PLoS Genet. 2006;2:e131 pubmed..These STAT1 alleles define two forms of dominant STAT1 deficiency, depending on whether the mutations impair STAT1 phosphorylation or DNA binding. ..
- Azouz A, Wu Y, Hillion J, Tarkanyi I, Karniguian A, Aradi J, et al. Epigenetic plasticity of hTERT gene promoter determines retinoid capacity to repress telomerase in maturation-resistant acute promyelocytic leukemia cells. Leukemia. 2010;24:613-22 pubmed publisher..We propose that epigenetic modifications targeting this distal region could modulate the binding of hTERT repressors and account either for hTERT reactivation and resistance to retinoid-induced hTERT downregulation. ..
- Stoppa Lyonnet D, Soulier J, Lauge A, Dastot H, Garand R, Sigaux F, et al. Inactivation of the ATM gene in T-cell prolymphocytic leukemias. Blood. 1998;91:3920-6 pubmed..ATM is thus a tumor suppressor gene whose inactivation is a key event in the development of T-cell prolymphocytic leukemias. ..
- Hached K, Xie S, Buffin E, Cladière D, Rachez C, Sacras M, et al. Mps1 at kinetochores is essential for female mouse meiosis I. Development. 2011;138:2261-71 pubmed publisher..In addition, we settle a long-standing question in showing that kinetochore-microtubule attachments are present in prometaphase I at a time when most of the SAC protein Mad2 disappears from kinetochores. ..
- Jullien Flores V, Dorseuil O, Romero F, Letourneur F, Saragosti S, Berger R, et al. Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activity. J Biol Chem. 1995;270:22473-7 pubmed..We propose that these pathways are linked through a cascade composed of Ras --> Ra1GDS --> Ra1 --> RLIP76 --> CDC42/Rac1/Rho, allowing modulation of the Rho pathway by the Ras pathway...
- Geha S, Pallud J, Junier M, Devaux B, Leonard N, Chassoux F, et al. NG2+/Olig2+ cells are the major cycle-related cell population of the adult human normal brain. Brain Pathol. 2010;20:399-411 pubmed publisher..These results provide evidence for a persistent gliogenesis in the human cortex and white matter that is enhanced in an epileptic environment. ..
- Soares D, Battistella A, Rocca C, Matuo R, Henriques J, Larsen A, et al. Ataxia telangiectasia mutated- and Rad3-related kinase drives both the early and the late DNA-damage response to the monofunctional antitumour alkylator S23906. Biochem J. 2011;437:63-73 pubmed publisher..These findings identify ATR as a central co-ordinator of the DNA-damage response to S23906, and provide a mechanistic rationale for combinations of S23906 and similar agents with checkpoint abrogators. ..
- JemaÃ M, Manic G, Lledo G, Lissa D, Reynès C, Morin N, et al. Whole-genome duplication increases tumor cell sensitivity to MPS1 inhibition. Oncotarget. 2016;7:885-901 pubmed publisher..Altogether, our results suggest that MPS1 inhibition could be used as a therapeutic strategy for targeting tetraploid cancer cells. ..
- Esterle L, Sabatier J, Guillon Metz F, Walrant Debray O, Guaydier Souquières G, Jehan F, et al. Milk, rather than other foods, is associated with vertebral bone mass and circulating IGF-1 in female adolescents. Osteoporos Int. 2009;20:567-75 pubmed publisher..Aside from being a major source of calcium, milk provides phosphates, magnesium, proteins, and as yet unidentified nutrients likely to favor bone health. ..
- Millecamps S, Corcia P, Cazeneuve C, Boillee S, Seilhean D, Danel Brunaud V, et al. Mutations in UBQLN2 are rare in French amyotrophic lateral sclerosis. Neurobiol Aging. 2012;33:839.e1-3 pubmed publisher..This variant did not segregate with the disease in the corresponding family and was also detected in 1/380 control subject. Our results suggest that UBQLN2 gene mutations are rare in French ALS. ..
- Maire V, Baldeyron C, Richardson M, Tesson B, Vincent Salomon A, Gravier E, et al. TTK/hMPS1 is an attractive therapeutic target for triple-negative breast cancer. PLoS ONE. 2013;8:e63712 pubmed publisher..These results point out TTK as a protein kinase overexpressed in TNBC that may represent an attractive therapeutic target specifically for this poor prognosis associated subgroup of breast cancer. ..
- Nordmann P, Poirel L. Emerging carbapenemases in Gram-negative aerobes. Clin Microbiol Infect. 2002;8:321-31 pubmed..Because most of these carbapenemases confer only reduced susceptibility to carbapenems in Enterobacteriaceae, they may remain underestimated as a consequence of the lack of their detection. ..
- Maire V, Nemati F, Richardson M, Vincent Salomon A, Tesson B, Rigaill G, et al. Polo-like kinase 1: a potential therapeutic option in combination with conventional chemotherapy for the management of patients with triple-negative breast cancer. Cancer Res. 2013;73:813-23 pubmed publisher..Altogether, our observations suggest PLK1 inhibition as an attractive therapeutic approach, in association with conventional chemotherapy, for the management of patients with TNBC. ..
- Ghigo J, Weiss D, Chen J, Yarrow J, Beckwith J. Localization of FtsL to the Escherichia coli septal ring. Mol Microbiol. 1999;31:725-37 pubmed..We propose that FtsL is a relatively late recruit to the ring structure that mediates septation. ..
- Périn J P -, Seddiqi N, Charbonnier F, Goudou D, Belkadi L, Rieger F, et al. Genomic organization and expression of the ubiquitin-proteasome complex-associated protein Rbx1/ROC1/Hrt1. Cell Mol Biol (Noisy-le-grand). 1999;45:1131-7 pubmed
- Camus A, Mesbah K, Rallu M, Babinet C, Barra J. Gene trap insertion reveals two open reading frames in the mouse SSeCKS gene: the form predominantly detected in the nervous system is suppressed by the insertion while the other, specific of the testis, remains expressed. Mech Dev. 2001;105:79-91 pubmed..Nevertheless and surprisingly, these mice do not exhibit any obvious phenotype. The functional implications of these observations are discussed. ..
- Terret M, Ferby I, Nebreda A, Verlhac M. RINGO efficiently triggers meiosis resumption in mouse oocytes and induces cell cycle arrest in embryos. Biol Cell. 2001;93:89-97 pubmed..The injection of RINGO mimics Mos effects: GVBD induction and efficient cleavage arrest. However, our results in mouse oocytes suggest that RINGO may have additional functions in meiosis regulation. ..
- Poinsignon C, de Chasseval R, Soubeyrand S, Moshous D, Fischer A, Haché R, et al. Phosphorylation of Artemis following irradiation-induced DNA damage. Eur J Immunol. 2004;34:3146-55 pubmed..Thus, Artemis is an effector of DNA repair that can be phosphorylated by ATM, and possibly by DNA-PKcs and ATR depending upon the type of DNA damage. ..
- David N, Martin C, Segalen M, Rosenfeld F, Schweisguth F, Bellaiche Y. Drosophila Ric-8 regulates Galphai cortical localization to promote Galphai-dependent planar orientation of the mitotic spindle during asymmetric cell division. Nat Cell Biol. 2005;7:1083-90 pubmed..Thus, Frizzled and heterotrimeric G-protein signalling act in opposition to ensure that the spindle aligns both in the plane of the epithelium and along the tissue polarity axis. ..
- Latasa M, Couton D, Charvet C, Lafanechère A, Guidotti J, Li Z, et al. Delayed liver regeneration in mice lacking liver serum response factor. Am J Physiol Gastrointest Liver Physiol. 2007;292:G996-G1001 pubmed..In conclusion, our work suggests that SRF is an early response transcription factor that may contribute to the initial phases of liver regeneration through its activation of IEGs. ..
- Bivik C, MacDonald R, Gunnar E, Mazouni K, Schweisguth F, Thor S. Control of Neural Daughter Cell Proliferation by Multi-level Notch/Su(H)/E(spl)-HLH Signaling. PLoS Genet. 2016;12:e1005984 pubmed publisher..These results point to a multi-level signaling model and may help shed light on the dichotomous proliferative role of Notch signaling in many other systems. ..
- Lefebvre C, Terret M, Djiane A, Rassinier P, Maro B, Verlhac M. Meiotic spindle stability depends on MAPK-interacting and spindle-stabilizing protein (MISS), a new MAPK substrate. J Cell Biol. 2002;157:603-13 pubmed..We therefore have discovered a new MAPK substrate involved in maintaining spindle integrity during the CSF arrest of mouse oocytes, called MISS (for MAP kinase-interacting and spindle-stabilizing protein). ..
- Pineau P, Marchio A, Nagamori S, Seki S, Tiollais P, Dejean A. Homozygous deletion scanning in hepatobiliary tumor cell lines reveals alternative pathways for liver carcinogenesis. Hepatology. 2003;37:852-61 pubmed..In conclusion, our data suggest that these genes may represent novel liver tumor suppressive targets. Additional tumorigenic pathways should be carefully considered in hepatocarcinogenesis. ..
- Bieche I, Manceau V, Curmi P, Laurendeau I, Lachkar S, Leroy K, et al. Quantitative RT-PCR reveals a ubiquitous but preferentially neural expression of the KIS gene in rat and human. Brain Res Mol Brain Res. 2003;114:55-64 pubmed
- Paoletti A, Bordes N, Haddad R, Schwartz C, Chang F, Bornens M. Fission yeast cdc31p is a component of the half-bridge and controls SPB duplication. Mol Biol Cell. 2003;14:2793-808 pubmed
- Levy L, Wei Y, Labalette C, Wu Y, Renard C, Buendia M, et al. Acetylation of beta-catenin by p300 regulates beta-catenin-Tcf4 interaction. Mol Cell Biol. 2004;24:3404-14 pubmed..Thus, our results describe a new mechanism by which p300 might regulate beta-catenin transcriptional activity. ..
- Lener M, Fernandes M, Poirier C, Bazzali Hernandez C, Tosi M, Meo T. The C1 inhibitor encoding gene (C1nh) maps to mouse chromosome 2. Mamm Genome. 1998;9:94 pubmed
- Colucci F, Rosmaraki E, Bregenholt S, Samson S, Di Bartolo V, Turner M, et al. Functional dichotomy in natural killer cell signaling: Vav1-dependent and -independent mechanisms. J Exp Med. 2001;193:1413-24 pubmed..These results highlight fundamental differences between proximal signaling events in T and NK cells and suggest a functional dichotomy for Vav1 in NK cells: a role in cytotoxicity but not for IFN-gamma production. ..
- Estrabaud E, Le Rouzic E, Lopez Verges S, Morel M, Belaïdouni N, Benarous R, et al. Regulated degradation of the HIV-1 Vpu protein through a betaTrCP-independent pathway limits the release of viral particles. PLoS Pathog. 2007;3:e104 pubmed..Conservation of the Vpu degradation determinant, despite its negative effect on virion release, argues for a role in overall HIV-1 fitness. ..
- Perfettini J, Nardacci R, Séror C, Bourouba M, Subra F, Gros L, et al. The tumor suppressor protein PML controls apoptosis induced by the HIV-1 envelope. Cell Death Differ. 2009;16:298-311 pubmed publisher..Altogether, these data indicate that PML activation is a critical early event that participates in the apoptotic demise of HIV-1-elicited syncytia. ..
- El Shamieh S, Neuillé M, Terray A, Orhan E, Condroyer C, Démontant V, et al. Whole-exome sequencing identifies KIZ as a ciliary gene associated with autosomal-recessive rod-cone dystrophy. Am J Hum Genet. 2014;94:625-33 pubmed publisher..Immunohistology revealed KIZ localization at the basal body of the cilia in human fibroblasts, thus shedding light on another ciliary protein implicated in autosomal-recessive RCD. ..
- Blanco I, Kuchenbaecker K, Cuadras D, Wang X, Barrowdale D, de Garibay G, et al. Assessing associations between the AURKA-HMMR-TPX2-TUBG1 functional module and breast cancer risk in BRCA1/2 mutation carriers. PLoS ONE. 2015;10:e0120020 pubmed publisher..Together, the results of this study support the hypothesis of a causative link between altered function of AURKA-HMMR-TPX2-TUBG1 and breast carcinogenesis in BRCA1/2 mutation carriers. ..
- Thomas Y, Cirillo L, Panbianco C, Martino L, Tavernier N, Schwager F, et al. Cdk1 Phosphorylates SPAT-1/Bora to Promote Plk1 Activation in C. elegans and Human Cells. Cell Rep. 2016;15:510-518 pubmed publisher..Our results reveal a crucial and conserved role of phosphorylation of the N terminus of Bora for Plk1 activation and mitotic entry. ..
- Wang Y, Toury R, Hauchecorne M, Balmain N. Expression and subcellular localization of the Myc superfamily proteins: c-Myc, Max, Mad1 and Mxi1 in the epiphyseal plate cartilage chondrocytes of growing rats. Cell Mol Biol (Noisy-le-grand). 1997;43:175-88 pubmed..The variations in immuno-patterns and intracellular distributions suggest that each protooncogene protein has specific roles in the functional changes in the chondrocytes at each step of their terminal differentiation. ..
- Calipel A, Lefevre G, Pouponnot C, Mouriaux F, Eychene A, Mascarelli F. Mutation of B-Raf in human choroidal melanoma cells mediates cell proliferation and transformation through the MEK/ERK pathway. J Biol Chem. 2003;278:42409-18 pubmed..Our results pinpoint this pathway as an important component in choroidal melanoma cell lines. ..
- Le Toriellec E, Despouy G, Pierron G, Gaye N, Joiner M, Bellanger D, et al. Haploinsufficiency of CDKN1B contributes to leukemogenesis in T-cell prolymphocytic leukemia. Blood. 2008;111:2321-8 pubmed..The second Cdkn1b allele was maintained and expressed in these preleukemic clones. Altogether, these data strongly implicate CDKN1B haploinsufficiency in the pathogenesis of T-PLL. ..
- Ossareh Nazari B, Cohen M, Dargemont C. The Rsp5 ubiquitin ligase and the AAA-ATPase Cdc48 control the ubiquitin-mediated degradation of the COPII component Sec23. Exp Cell Res. 2010;316:3351-7 pubmed publisher..Our data favor the idea that Cdc48 plays a key role in deciphering fates of ubiquitylated Sec23 to degradation or deubiquitylation/stabilization via its cofactors. ..
- Romero F, Dargemont C, Pozo F, Reeves W, Camonis J, Gisselbrecht S, et al. p95vav associates with the nuclear protein Ku-70. Mol Cell Biol. 1996;16:37-44 pubmed..Therefore, the interaction of Vav with Ku-70 may be a novel form of protein-protein interaction. The potential role of Vav/Ku-70 complexes is discussed. ..
- Niault T, Hached K, Sotillo R, Sorger P, Maro B, Benezra R, et al. Changing Mad2 levels affects chromosome segregation and spindle assembly checkpoint control in female mouse meiosis I. PLoS ONE. 2007;2:e1165 pubmed..Furthermore, SAC control is impaired in mad2+/- oocytes, also leading to the generation of aneuploidies in meiosis I. ..
- Dargemont C, Ossareh Nazari B. Cdc48/p97, a key actor in the interplay between autophagy and ubiquitin/proteasome catabolic pathways. Biochim Biophys Acta. 2012;1823:138-44 pubmed publisher..This review will focus on the recently described functions of Cdc48/p97 in autophagosome biogenesis as well as selective autophagy. ..
- Gineau L, Cognet C, Kara N, Lach F, Dunne J, Veturi U, et al. Partial MCM4 deficiency in patients with growth retardation, adrenal insufficiency, and natural killer cell deficiency. J Clin Invest. 2012;122:821-32 pubmed publisher..Thus, partial MCM4 deficiency results in a genetic syndrome of growth retardation with adrenal insufficiency and selective NK deficiency. ..
- Coue M, Kearsey S, Mechali M. Chromatin binding, nuclear localization and phosphorylation of Xenopus cdc21 are cell-cycle dependent and associated with the control of initiation of DNA replication. EMBO J. 1996;15:1085-97 pubmed..These properties identify Xenopus cdc21 as a possible component of the DNA licensing factor. ..
- Wassmann K, Niault T, Maro B. Metaphase I arrest upon activation of the Mad2-dependent spindle checkpoint in mouse oocytes. Curr Biol. 2003;13:1596-608 pubmed..Our study shows for the first time that a functional Mad2-dependent spindle checkpoint exists during the first meiotic division in mammalian oocytes. ..
- Veiga Fernandes H, Rocha B. High expression of active CDK6 in the cytoplasm of CD8 memory cells favors rapid division. Nat Immunol. 2004;5:31-7 pubmed..Therefore G0/G1 memory cells are at a unique preactivated state that favors rapid division after antigen stimulation. ..
- Miserey Lenkei S, Couëdel Courteille A, del Nery E, Bardin S, Piel M, Racine V, et al. A role for the Rab6A' GTPase in the inactivation of the Mad2-spindle checkpoint. EMBO J. 2006;25:278-89 pubmed..Rab6A', through its interaction with p150(Glued) and GAPCenA, may thus participate in a pathway involved in the metaphase/anaphase transition. ..
- Warcoin M, Lespinasse J, Despouy G, Dubois d Enghien C, Lauge A, Portnoi M, et al. Fertility defects revealing germline biallelic nonsense NBN mutations. Hum Mutat. 2009;30:424-30 pubmed publisher..NBN mutations should thus be considered a new cause of infertility, and should be searched for if associated with the biological abnormalities of NBS. ..
- Breuer M, Kolano A, Kwon M, Li C, Tsai T, Pellman D, et al. HURP permits MTOC sorting for robust meiotic spindle bipolarity, similar to extra centrosome clustering in cancer cells. J Cell Biol. 2010;191:1251-60 pubmed publisher..Furthermore, HURP is also required for the clustering of extra centrosomes before division, arguing for a shared molecular requirement of MTOC sorting in mammalian meiosis and cancer cell division. ..
- Jonquoy A, Mugniery E, Benoist Lasselin C, Kaci N, Le Corre L, Barbault F, et al. A novel tyrosine kinase inhibitor restores chondrocyte differentiation and promotes bone growth in a gain-of-function Fgfr3 mouse model. Hum Mol Genet. 2012;21:841-51 pubmed publisher..Our data reveal a specific role for FGFR3 in the cell cycle and chondrocyte differentiation and support the development of TKIs for the treatment of FGFR3-related chondrodysplasias. ..
- Heide S, Keren B, Billette De Villemeur T, Chantot Bastaraud S, Depienne C, Nava C, et al. Copy Number Variations Found in Patients with a Corpus Callosum Abnormality and Intellectual Disability. J Pediatr. 2017;185:160-166.e1 pubmed publisher..Our results confirm the relevance of using microarray analysis as first line test in patients with corpus callosum abnormality/intellectual disability. ..
- Ramos Morales F, Romero F, Schweighoffer F, Bismuth G, Camonis J, Tortolero M, et al. The proline-rich region of Vav binds to Grb2 and Grb3-3. Oncogene. 1995;11:1665-9 pubmed..In addition we show that Vav also interacts with Grb3-3, a naturally occurring Grb2 isoform wich lacks functional SH2 domain. ..
- Karaiskou A, DuPre A, Haccard O, Jessus C. From progesterone to active Cdc2 in Xenopus oocytes: a puzzling signalling pathway. Biol Cell. 2001;93:35-46 pubmed
- Pène F, Claessens Y, Muller O, Viguie F, Mayeux P, Dreyfus F, et al. Role of the phosphatidylinositol 3-kinase/Akt and mTOR/P70S6-kinase pathways in the proliferation and apoptosis in multiple myeloma. Oncogene. 2002;21:6587-97 pubmed..Moreover, constitutive activation of this pathway is a frequent event in the biology of MM in vivo and may be more frequently observed in PCL. ..
- Terret M, Wassmann K, Waizenegger I, Maro B, Peters J, Verlhac M. The meiosis I-to-meiosis II transition in mouse oocytes requires separase activity. Curr Biol. 2003;13:1797-802 pubmed..We therefore investigated if Separase activity is required for correct chromosome segregation in meiosis I in mouse oocytes. ..
- Haccard O, Jessus C. Greatwall kinase, ARPP-19 and protein phosphatase 2A: shifting the mitosis paradigm. Results Probl Cell Differ. 2011;53:219-34 pubmed publisher..These findings provide a new element of paramount importance in the control of mitosis...
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