Genomes and Genes
Experts and Doctors on bacterial proteins in Paris, Île de France, France
Locale: Paris, Île de France, France
Topic: bacterial proteins
Publications280 found, 100 shown here
- Depardieu F, Bonora M, Reynolds P, Courvalin P. The vanG glycopeptide resistance operon from Enterococcus faecalis revisited. Mol Microbiol. 2003;50:931-48 pubmed..Sequence determination of the flanking regions of the vanG cluster in donor and transconjugants revealed the same 4 bp direct repeats and 22 bp imperfect inverted repeats that delineated the large element. ..
- Arluison V, Folichon M, Marco S, Derreumaux P, Pellegrini O, Seguin J, et al. The C-terminal domain of Escherichia coli Hfq increases the stability of the hexamer. Eur J Biochem. 2004;271:1258-65 pubmed..On the basis of these results, we propose that the C-terminal domain could protect the interface between the subunits and stabilize the hexameric Hfq structure. The origin of this C-terminal domain is also discussed. ..
- Cazalet C, Gomez Valero L, Rusniok C, Lomma M, Dervins Ravault D, Newton H, et al. Analysis of the Legionella longbeachae genome and transcriptome uncovers unique strategies to cause Legionnaires' disease. PLoS Genet. 2010;6:e1000851 pubmed publisher..longbeachae is encapsulated. These species-specific differences may account for the different environmental niches and disease epidemiology of these two Legionella species...
- Pennini M, Perrinet S, Dautry Varsat A, Subtil A. Histone methylation by NUE, a novel nuclear effector of the intracellular pathogen Chlamydia trachomatis. PLoS Pathog. 2010;6:e1000995 pubmed publisher..Thus, NUE is secreted by Chlamydia, translocates to the host cell nucleus and has enzymatic activity towards eukaryotic substrates. This work is the first description of a bacterial effector that directly targets mammalian histones. ..
- André G, Haudecoeur E, Monot M, Ohtani K, Shimizu T, Dupuy B, et al. Global regulation of gene expression in response to cysteine availability in Clostridium perfringens. BMC Microbiol. 2010;10:234 pubmed publisher..The existence of links between the C. perfringens virulence regulon and sulfur metabolism prompted us to analyze this metabolism in more detail...
- Poirel L, Al Maskari Z, Al Rashdi F, Bernabeu S, Nordmann P. NDM-1-producing Klebsiella pneumoniae isolated in the Sultanate of Oman. J Antimicrob Chemother. 2011;66:304-6 pubmed publisher..In both isolates, the bla(NDM-1) gene was located on plasmids that were of similar size (170 kb), but of different incompatibility groups. This is the first description of NDM-1 producers in the Arabian peninsula and in the Middle East. ..
- Rolando M, Buchrieser C. Post-translational modifications of host proteins by Legionella pneumophila: a sophisticated survival strategy. Future Microbiol. 2012;7:369-81 pubmed publisher..In this review, we focus on those effectors in the repertoire of L. pneumophila proteins that target key cellular pathways by specific post-translational modifications...
- Caillet Saguy C, Piccioli M, Turano P, Lukat Rodgers G, Wolff N, Rodgers K, et al. Role of the iron axial ligands of heme carrier HasA in heme uptake and release. J Biol Chem. 2012;287:26932-43 pubmed publisher..Here, we demonstrate that these states do not naturally occur in the free protein but can only be driven by the interaction with the partner proteins. ..
- Durand S, Jahn N, Condon C, Brantl S. Type I toxin-antitoxin systems in Bacillus subtilis. RNA Biol. 2012;9:1491-7 pubmed publisher..Here we review what is known about these confirmed and putative toxin-antitoxin families in B. subtilis, their regulatory mechanisms, their potential roles and how they may link to the physiology of the cell. ..
- Turlin E, Debarbouille M, Augustyniak K, Gilles A, Wandersman C. Staphylococcus aureus FepA and FepB proteins drive heme iron utilization in Escherichia coli. PLoS ONE. 2013;8:e56529 pubmed publisher..Our results show that the function in heme iron extraction is conserved in the two orthologous systems. ..
- Plumbridge J. A dominant mutation in the gene for the Nag repressor of Escherichia coli that renders the nag regulon uninducible. J Gen Microbiol. 1992;138:1011-7 pubmed..The mutation is semi-dominant since heterozygous diploids have reduced growth rates on glucosamine and N-acetylglucosamine compared to the wild-type strain. ..
- Kaminski P, Mandon K, Arigoni F, Desnoues N, Elmerich C. Regulation of nitrogen fixation in Azorhizobium caulinodans: identification of a fixK-like gene, a positive regulator of nifA. Mol Microbiol. 1991;5:1983-91 pubmed..A model of regulation, based on these data, is presented and might explain the unusual ability of A. caulinodans to fix nitrogen both under symbiotic conditions and in the free-living state. ..
- Msadek T, Kunst F, Rapoport G. MecB of Bacillus subtilis, a member of the ClpC ATPase family, is a pleiotropic regulator controlling competence gene expression and growth at high temperature. Proc Natl Acad Sci U S A. 1994;91:5788-92 pubmed..In response to an unknown signal, active ComK would accumulate through a positive feedback loop, leading to expression of competence genes allowing DNA uptake. ..
- Pugsley A, Francetic O. Protein secretion in Escherichia coli K-12: dead or alive?. Cell Mol Life Sci. 1998;54:347-52 pubmed
- Rowe Magnus D, Guerout A, Mazel D. Bacterial resistance evolution by recruitment of super-integron gene cassettes. Mol Microbiol. 2002;43:1657-69 pubmed..These results demonstrate that otherwise phenotypically sensitive strains may still be a genetic source for the evolution of resistance to clinically relevant antibiotics through integron-mediated recombination events...
- Nora T, Lomma M, Gomez Valero L, Buchrieser C. Molecular mimicry: an important virulence strategy employed by Legionella pneumophila to subvert host functions. Future Microbiol. 2009;4:691-701 pubmed publisher..Collectively, these data have shed new light on the virulence strategies of L. pneumophila, a major aspect of which is molecular mimicry. ..
- Allaoui A, Mounier J, Pr vost M, Sansonetti P, Parsot C. icsB: a Shigella flexneri virulence gene necessary for the lysis of protrusions during intercellular spread. Mol Microbiol. 1992;6:1605-16 pubmed..These results indicate that IcsB is involved in the lysis of the protrusions, a step necessary for intercellular spread...
- Bachellier S, Clement J, Hofnung M, Gilson E. Bacterial interspersed mosaic elements (BIMEs) are a major source of sequence polymorphism in Escherichia coli intergenic regions including specific associations with a new insertion sequence. Genetics. 1997;145:551-62 pubmed..Unlike BIMEs, IS 1397 is not detected in all E. coli isolates. Possible relationships between the presence of this IS element and the evolution of BIMEs are discussed. ..
- Geissmann T, Touati D. Hfq, a new chaperoning role: binding to messenger RNA determines access for small RNA regulator. EMBO J. 2004;23:396-405 pubmed..Thus, Hfq is a critical chaperone in vivo and in vitro, changing the folding of the target mRNA to make it subject to the small RNA regulator. ..
- Ruimy R, Armand Lefevre L, Barbier F, Ruppe E, Cocojaru R, Mesli Y, et al. Comparisons between geographically diverse samples of carried Staphylococcus aureus. J Bacteriol. 2009;191:5577-83 pubmed publisher..Phylogenetic analysis revealed a highly divergent and uncharacterized genotype (ST1223) within Cambodia. This lineage is related to CC75, which has previously been observed only in remote aboriginal populations in northern Australia. ..
- Laalami S, Sacerdot C, Vachon G, Mortensen K, Sperling Petersen H, Cenatiempo Y, et al. Structural and functional domains of E coli initiation factor IF2. Biochimie. 1991;73:1557-66 pubmed..Here we review evidence which indicates the functional importance of the different structural domains of IF2, emphasizing new information obtained by in vivo experiments. ..
- Debarbouille M, Martin Verstraete I, Kunst F, Rapoport G. The Bacillus subtilis sigL gene encodes an equivalent of sigma 54 from gram-negative bacteria. Proc Natl Acad Sci U S A. 1991;88:9092-6 pubmed..These results indicate that the sigL gene encodes an equivalent of the sigma 54 factor in B. subtilis, to our knowledge, the first of this type to be identified in Gram-positive bacteria. ..
- Gilson E, Perrin D, Hofnung M. DNA polymerase I and a protein complex bind specifically to E. coli palindromic unit highly repetitive DNA: implications for bacterial chromosome organization. Nucleic Acids Res. 1990;18:3941-52 pubmed..The other activity contained at least five polypeptides. Its binding to PU DNA sequences was confirmed by native gel electrophoresis. Implications for the possible origin and functions of PU are discussed. ..
- Bonnefoy E, Almeida A, Rouviere Yaniv J. Lon-dependent regulation of the DNA binding protein HU in Escherichia coli. Proc Natl Acad Sci U S A. 1989;86:7691-5 pubmed
- Heym B, Alzari P, Honor N, Cole S. Missense mutations in the catalase-peroxidase gene, katG, are associated with isoniazid resistance in Mycobacterium tuberculosis. Mol Microbiol. 1995;15:235-45 pubmed..The second group comprises a frequently occurring amino acid substitution and a single mutation that are both located in the C-terminal domain but do not noticeably alter either enzyme activity or heat stability...
- Cruz Ramos H, Boursier L, Moszer I, Kunst F, Danchin A, Glaser P. Anaerobic transcription activation in Bacillus subtilis: identification of distinct FNR-dependent and -independent regulatory mechanisms. EMBO J. 1995;14:5984-94 pubmed..Thus induction of genes involved in anaerobic respiration requires in B.subtilis at least two levels of regulation: activation of fnr transcription and activation of FNR to induce transcription of FNR-dependent promoters. ..
- Joutel A, Ducros A, Alamowitch S, Cruaud C, Domenga V, Marechal E, et al. A human homolog of bacterial acetolactate synthase genes maps within the CADASIL critical region. Genomics. 1996;38:192-8 pubmed
- Arthur M, Depardieu F, Cabanie L, Reynolds P, Courvalin P. Requirement of the VanY and VanX D,D-peptidases for glycopeptide resistance in enterococci. Mol Microbiol. 1998;30:819-30 pubmed..Thus, VanX and VanY had non-overlapping functions involving the hydrolysis of D-Ala-D-Ala and the removal of D-Ala from membrane-bound lipid intermediates respectively. ..
- Mavris M, Page A, Tournebize R, Demers B, Sansonetti P, Parsot C. Regulation of transcription by the activity of the Shigella flexneri type III secretion apparatus. Mol Microbiol. 2002;43:1543-53 pubmed..This suggests that the activity of secretion is sensed by the presence of free IpgC, which acts as a coactivator to allow MxiE to activate transcription at its target promoters...
- Vignon G, Köhler R, Larquet E, Giroux S, Prevost M, Roux P, et al. Type IV-like pili formed by the type II secreton: specificity, composition, bundling, polar localization, and surface presentation of peptides. J Bacteriol. 2003;185:3416-28 pubmed..Abnormally long pili that extend beyond the outer membrane are produced only when pilus length control and retraction are deregulated by overproduction of the major pseudopilus subunit (PulG). ..
- Slamti L, Perchat S, Gominet M, Vilas B as G, Fouet A, Mock M, et al. Distinct mutations in PlcR explain why some strains of the Bacillus cereus group are nonhemolytic. J Bacteriol. 2004;186:3531-8 pubmed publisher..We also found that the plcR genes of three B. anthracis strains belonging to different phylogenetic groups contained the same nonsense mutation, suggesting that this mutation is a distinctive trait of this species...
- Kim D, Lenzen G, Page A, Legrain P, Sansonetti P, Parsot C. The Shigella flexneri effector OspG interferes with innate immune responses by targeting ubiquitin-conjugating enzymes. Proc Natl Acad Sci U S A. 2005;102:14046-51 pubmed..This finding indicates that OspG negatively controls the host innate response induced by S. flexneri upon invasion of the epithelium. ..
- Davison S, Couture Tosi E, Candela T, Mock M, Fouet A. Identification of the Bacillus anthracis (gamma) phage receptor. J Bacteriol. 2005;187:6742-9 pubmed..B. thuringiensis 97-27, a strain which, by sequence analysis, is predicted to harbor a GamR-like protein, is resistant to the phage but nevertheless displays phage binding...
- Courvalin P. Vancomycin resistance in gram-positive cocci. Clin Infect Dis. 2006;42 Suppl 1:S25-34 pubmed..The diversity, regulation, evolution, and recent dissemination of methicillin-resistant Staphylococcus aureus are then discussed. ..
- Aires J, Doucet Populaire F, Butel M. Tetracycline resistance mediated by tet(W), tet(M), and tet(O) genes of Bifidobacterium isolates from humans. Appl Environ Microbiol. 2007;73:2751-4 pubmed..tet(W) and tet(M) were found in 26 and 7%, respectively, of the Bifidobacterium isolates, and one isolate contained both genes. Chromosomal DNA hybridization showed that there was one chromosomal copy of tet(W) and/or tet(M)...
- Veziris N, Martin C, Brossier F, Bonnaud F, Denis F, Aubry A. Treatment failure in a case of extensively drug-resistant tuberculosis associated with selection of a GyrB mutant causing fluoroquinolone resistance. Eur J Clin Microbiol Infect Dis. 2007;26:423-5 pubmed
- Haentjens Sitri J, Allemand F, Springer M, Chiaruttini C. A competition mechanism regulates the translation of the Escherichia coli operon encoding ribosomal proteins L35 and L20. J Mol Biol. 2008;375:612-25 pubmed..We show that the pseudoknot, which is known to be essential for L20 binding and regulation, also enhances 30S binding to mRNA as if this structure is specifically recognised by the ribosome. ..
- Sacquin Mora S, Sebban P, Derrien V, Frick B, Lavery R, Alba Simionesco C. Probing the flexibility of the bacterial reaction center: the wild-type protein is more rigid than two site-specific mutants. Biochemistry. 2007;46:14960-8 pubmed..L212Glu, which is systematically conserved in all photosynthetic bacteria, seems to be one of the key residues that exerts a distant control over the rigidity of the core of the protein. ..
- Delevoye C, Nilges M, Dehoux P, Paumet F, Perrinet S, Dautry Varsat A, et al. SNARE protein mimicry by an intracellular bacterium. PLoS Pathog. 2008;4:e1000022 pubmed publisher..Moreover, point mutations in the central layer of IncA SNARE-like motifs resulted in the loss of binding to host SNAREs. Altogether, our data demonstrate for the first time mimicry of the SNARE motif by a bacterium. ..
- Servet C, Ghelis T, Richard L, Zilberstein A, Savoure A. Proline dehydrogenase: a key enzyme in controlling cellular homeostasis. Front Biosci (Landmark Ed). 2012;17:607-20 pubmed
- Meinzer U, Barreau F, Esmiol Welterlin S, Jung C, Villard C, Léger T, et al. Yersinia pseudotuberculosis effector YopJ subverts the Nod2/RICK/TAK1 pathway and activates caspase-1 to induce intestinal barrier dysfunction. Cell Host Microbe. 2012;11:337-51 pubmed publisher..Thus, YopJ alters intestinal permeability and promotes the dissemination of Yersinia as well as commensal bacteria by exploiting the mucosal inflammatory response...
- Govind R, Dupuy B. Secretion of Clostridium difficile toxins A and B requires the holin-like protein TcdE. PLoS Pathog. 2012;8:e1002727 pubmed publisher..TcdE appears to be the first example of a bacterial protein that releases toxins into the environment by a phage-like system...
- Rebuffat S. Microcins in action: amazing defence strategies of Enterobacteria. Biochem Soc Trans. 2012;40:1456-62 pubmed publisher..They offer new and promising tracks for further design and engineering of novel efficient antibiotics. ..
- Collot M, Wilms C, Bentkhayet A, Marcaggi P, Couchman K, Charpak S, et al. CaRuby-Nano: a novel high affinity calcium probe for dual color imaging. elife. 2015;4: pubmed publisher..We tested the new indicator using in vitro and in vivo experiments demonstrating the high sensitivity of CaRuby-Nano as well as its power in dual color imaging experiments. ..
- Mazodier P, Guglielmi G, Davies J, Thompson C. Characterization of the groEL-like genes in Streptomyces albus. J Bacteriol. 1991;173:7382-6 pubmed..At least two groEL-like genes were present in all 12 Streptomyces species tested; they were not closely linked in the genome. groEL1, but not groEL2, was adjacent to a groES-like gene. ..
- Kaminski P, Elmerich C. Involvement of fixLJ in the regulation of nitrogen fixation in Azorhizobium caulinodans. Mol Microbiol. 1991;5:665-73 pubmed..Using pnifH-lacZ and pnifA-lacZ fusions, it was shown that the FixLJ products controlled the expression of nifH and nifA in bacteria grown in the free-living state. ..
- Raibaud O, Vidal Ingigliardi D, Richet E. A complex nucleoprotein structure involved in activation of transcription of two divergent Escherichia coli promoters. J Mol Biol. 1989;205:471-85 pubmed..We propose a model for the nucleoprotein structure that might be involved in transcription activation at these divergent promoters. ..
- Honor N, Bergh S, Chanteau S, Doucet Populaire F, Eiglmeier K, Garnier T, et al. Nucleotide sequence of the first cosmid from the Mycobacterium leprae genome project: structure and function of the Rif-Str regions. Mol Microbiol. 1993;7:207-14 pubmed..This finding may well be significant as M. leprae, an intracellular pathogen, lives within macrophages...
- Betton J, Boscus D, Missiakas D, Raina S, Hofnung M. Probing the structural role of an alpha beta loop of maltose-binding protein by mutagenesis: heat-shock induction by loop variants of the maltose-binding protein that form periplasmic inclusion bodies. J Mol Biol. 1996;262:140-50 pubmed..We found that the extent of formation of inclusion bodies in the periplasm of E. coli, from misfolded loop variant MBPs, correlated with the level of heat-shock response regulated by the alternate heat-shock sigma factor, sigma 24...
- Arthur M, Depardieu F, Gerbaud G, Galimand M, Leclercq R, Courvalin P. The VanS sensor negatively controls VanR-mediated transcriptional activation of glycopeptide resistance genes of Tn1546 and related elements in the absence of induction. J Bacteriol. 1997;179:97-106 pubmed..Activation of the VanR response regulator in the absence of VanS may involve autophosphorylation of VanR with acetyl phosphate or phosphorylation by a heterologous histidine protein kinase...
- Grillot Courvalin C, Goussard S, Huetz F, Ojcius D, Courvalin P. Functional gene transfer from intracellular bacteria to mammalian cells. Nat Biotechnol. 1998;16:862-6 pubmed..Expression of the acquired genes occurs in both dividing and quiescent cells. The only requirement for bacteria to transfer genetic material into nonprofessional phagocytic cells and macrophages is the ability to invade the host cell. ..
- Nassif X. Genomics of Neisseria meningitidis. Int J Med Microbiol. 2002;291:419-23 pubmed..This review will address the new possibilities offered by the recent availability of meningococcal genome sequences. ..
- Boccara M, Mills C, Zeier J, Anzi C, Lamb C, Poole R, et al. Flavohaemoglobin HmpX from Erwinia chrysanthemi confers nitrosative stress tolerance and affects the plant hypersensitive reaction by intercepting nitric oxide produced by the host. Plant J. 2005;43:226-37 pubmed
- Chaput C, Ecobichon C, Cayet N, Girardin S, Werts C, Guadagnini S, et al. Role of AmiA in the morphological transition of Helicobacter pylori and in immune escape. PLoS Pathog. 2006;2:e97 pubmed publisher..pylori infection...
- Coornaert A, Lu A, Mandin P, Springer M, Gottesman S, Guillier M. MicA sRNA links the PhoP regulon to cell envelope stress. Mol Microbiol. 2010;76:467-79 pubmed publisher..In addition, we found that Hfq strongly affects the expression of phoP independently of MicA, raising the possibility that even more sRNAs, which remain to be identified, could regulate PhoPQ synthesis. ..
- Beaufort N, Corvazier E, Hervieu A, Choqueux C, Dussiot M, Louedec L, et al. The thermolysin-like metalloproteinase and virulence factor LasB from pathogenic Pseudomonas aeruginosa induces anoikis of human vascular cells. Cell Microbiol. 2011;13:1149-67 pubmed publisher..Thus, among P. aeruginosa-secreted metalloproteinases, LasB can induce vascular cell anoikis through simultaneous proteolysis of ECM components and cell receptors, suggesting the uPAR-vitronectin axis as a major target in this process. ..
- Norel F, Pisano M, Nicoli J, Popoff M. Nucleotide sequence of the plasmid-borne virulence gene mkfA encoding a 28 kDa polypeptide from Salmonella typhimurium. Res Microbiol. 1989;140:263-5 pubmed
- Maucuer A, Camonis J, Sobel A. Stathmin interaction with a putative kinase and coiled-coil-forming protein domains. Proc Natl Acad Sci U S A. 1995;92:3100-4 pubmed..The molecular and biological characterization of KIS, CC1, and CC2 proteins will give further insights into the molecular functions and mechanisms of action of stathmin as a relay of integrated intracellular regulatory pathways. ..
- Lim E, Rauzier J, Timm J, Torrea G, Murray A, Gicquel B, et al. Identification of mycobacterium tuberculosis DNA sequences encoding exported proteins by using phoA gene fusions. J Bacteriol. 1995;177:59-65 pubmed..This approach thus appears to identify sequences directing protein export, and we expect that more extensive screening of such libraries will lead to a better understanding of protein export in M. tuberculosis. ..
- Calogero S, Gardan R, Glaser P, Schweizer J, Rapoport G, Debarbouille M. RocR, a novel regulatory protein controlling arginine utilization in Bacillus subtilis, belongs to the NtrC/NifA family of transcriptional activators. J Bacteriol. 1994;176:1234-41 pubmed..After LevR, RocR is the second example of an activator stimulating sigma 54-dependent promoters in gram-positive bacteria. ..
- Dumay V, Danchin A, Crasnier M. Regulation of Escherichia coli adenylate cyclase activity during hexose phosphate transport. Microbiology. 1996;142 ( Pt 3):575-83 pubmed..We present data indicating that Glc6P per se or its degradation is unlikely to be responsible for the low cAMP level. It is concluded that the level of cAMP in the cell is determined by the flux of Glc6P through UhpT. ..
- Camus A, Kress C, Babinet C, Barra J. Unexpected behavior of a gene trap vector comprising a fusion between the Sh ble and the lacZ genes. Mol Reprod Dev. 1996;45:255-63 pubmed..Germline chimeras were subsequently obtained and 15 mouse lines have been established. Intercrosses of animals heterozygous for the insertion revealed a mutant phenotype in several lines. ..
- Chiaruttini C, Milet M, Springer M. Translational coupling by modulation of feedback repression in the IF3 operon of Escherichia coli. Proc Natl Acad Sci U S A. 1997;94:9208-13 pubmed..The result is a novel type of translational coupling, where unfolding of the pseudoknot by ribosomes translating IF3 does not increase expression of L35 directly, but alleviates its repression by L20. ..
- De Reuse H, Taha M. RegF, an SspA homologue, regulates the expression of the Neisseria gonorrhoeae pilE gene. Res Microbiol. 1997;148:289-303 pubmed publisher..gonorrhoeae, RegF acts as a negative regulator of pilE transcription, and (ii) in E. coli, RegF increases pilE transcription by preventing sigma 54-associated steric hindrance at pilE promoters described previously...
- Possot O, Vignon G, Bomchil N, Ebel F, Pugsley A. Multiple interactions between pullulanase secreton components involved in stabilization and cytoplasmic membrane association of PulE. J Bacteriol. 2000;182:2142-52 pubmed
- Wolff N, Sapriel G, Bodenreider C, Chaffotte A, Delepelaire P. Antifolding activity of the SecB chaperone is essential for secretion of HasA, a quickly folding ABC pathway substrate. J Biol Chem. 2003;278:38247-53 pubmed..Refolding of both mutants was much slower than that of wild-type HasA and they were secreted essentially independently of SecB. We conclude that SecB has mainly an antifolding function in the HasA ABC secretion pathway. ..
- Raibaud S, Vachette P, Guillier M, Allemand F, Chiaruttini C, Dardel F. How bacterial ribosomal protein L20 assembles with 23 S ribosomal RNA and its own messenger RNA. J Biol Chem. 2003;278:36522-30 pubmed
- Sabet C, Lecuit M, Cabanes D, Cossart P, Bierne H. LPXTG protein InlJ, a newly identified internalin involved in Listeria monocytogenes virulence. Infect Immun. 2005;73:6912-22 pubmed publisher..In conclusion, this postgenomic approach identified InlJ as a new virulence factor among the proteins belonging to the internalin family in L. monocytogenes...
- Helaine S, Dyer D, Nassif X, Pelicic V, Forest K. 3D structure/function analysis of PilX reveals how minor pilins can modulate the virulence properties of type IV pili. Proc Natl Acad Sci U S A. 2007;104:15888-93 pubmed
- Matta M, Gousseff M, Monsel F, Poyart C, Diebold B, Podglajen I, et al. First case of Streptococcus oligofermentans endocarditis determined based on sodA gene sequences after amplification directly from valvular samples. J Clin Microbiol. 2009;47:855-6 pubmed publisher..It was responsible for the endocarditis and left forearm abscess of a 43-year-old woman. Identification was made using molecular techniques performed directly from valvular and surgical samples. ..
- Falord M, Mäder U, Hiron A, Debarbouille M, Msadek T. Investigation of the Staphylococcus aureus GraSR regulon reveals novel links to virulence, stress response and cell wall signal transduction pathways. PLoS ONE. 2011;6:e21323 pubmed publisher..This is the first report showing a role for the GraSR TCS in high temperature and oxidative stress survival and linking this system to stress response, cell wall and pathogenesis control pathways. ..
- Prevost M, Sauguet L, Nury H, Van Renterghem C, Huon C, Poitevin F, et al. A locally closed conformation of a bacterial pentameric proton-gated ion channel. Nat Struct Mol Biol. 2012;19:642-9 pubmed publisher..Further cross-linking, accessibility and molecular dynamics data suggest that the locally closed form is a functionally relevant conformation that occurs during allosteric gating transitions. ..
- Armand Lefevre L, Angebault C, Barbier F, Hamelet E, Defrance G, Ruppe E, et al. Emergence of imipenem-resistant gram-negative bacilli in intestinal flora of intensive care patients. Antimicrob Agents Chemother. 2013;57:1488-95 pubmed publisher..9 (95% confidence interval [95% CI], 1.5 to 25.7) after 1 to 3 days of exposure and increased to 7.8 (95% CI, 2.4 to 29.8) thereafter. In conclusion, even brief exposure to imipenem is a major risk factor for IR-GNB carriage. ..
- Basmaci R, Ilharreborde B, Doit C, Presedo A, Lorrot M, Alison M, et al. Two atypical cases of Kingella kingae invasive infection with concomitant human rhinovirus infection. J Clin Microbiol. 2013;51:3137-9 pubmed publisher..Both patients had concomitant human rhinovirus infection. K. kingae strains, isolated from an oropharyngeal swab, were characterized by multilocus sequence typing and rtxA sequencing. ..
- Loza Correa M, Sahr T, Rolando M, Daniels C, Petit P, Skarina T, et al. The Legionella pneumophila kai operon is implicated in stress response and confers fitness in competitive environments. Environ Microbiol. 2014;16:359-81 pubmed publisher..pneumophila?KaiBC resemble Synechosystis?KaiC2B2 and not circadian KaiB1C1. Thus, the L.?pneumophila?Kai proteins do not encode a circadian clock, but enhance stress resistance and adaption to changes in the environments. ..
- Fribourg P, Chami M, Sorzano C, Gubellini F, Marabini R, Marco S, et al. 3D cryo-electron reconstruction of BmrA, a bacterial multidrug ABC transporter in an inward-facing conformation and in a lipidic environment. J Mol Biol. 2014;426:2059-69 pubmed publisher..Overall, the data are consistent with a mechanism of drug transport involving large conformational changes of BmrA and show that a bacterial ABC exporter can adopt at least two open inward conformations in lipid membrane...
- van der Maarel J, Guttula D, Arluison V, Egelhaaf S, Grillo I, Forsyth V. Structure of the H-NS-DNA nucleoprotein complex. Soft Matter. 2016;12:3636-42 pubmed publisher..The two observed binding modes and their modulation by magnesium ions provide a structural basis for H-NS-mediated genome organisation and expression regulation. ..
- Rieck B, Degiacomi G, Zimmermann M, Cascioferro A, Boldrin F, Lazar Adler N, et al. PknG senses amino acid availability to control metabolism and virulence of Mycobacterium tuberculosis. PLoS Pathog. 2017;13:e1006399 pubmed publisher..This function in amino acid homeostasis is conserved amongst the Actinobacteria and provides an example of the close relationship between metabolism and virulence. ..
- Sun C, Wacquier B, Aguilar D, Carayol N, Denis K, Boucherie S, et al. The Shigella type III effector IpgD recodes Ca2+ signals during invasion of epithelial cells. EMBO J. 2017;36:2567-2580 pubmed publisher..Consistent with this function, IpgD prevents the Ca2+-dependent activation of calpain, thereby preserving the integrity of cell adhesion structures during the early stages of infection. ..
- Danchin A, Krin E. Filling the gap between hns and adhE in Escherichia coli K12. Microbiology. 1995;141 ( Pt 4):959-60 pubmed..We report the sequence of the hns-adh region, at 27 min on the genome. ..
- Kaminski P, Desnoues N, Elmerich C. The expression of nifA in Azorhizobium caulinodans requires a gene product homologous to Escherichia coli HF-I, an RNA-binding protein involved in the replication of phage Q beta RNA. Proc Natl Acad Sci U S A. 1994;91:4663-7 pubmed..A null mutant, constructed by disruption of nrfA, exhibited the same phenotype as the missense mutant. Thus, an additional factor can be added to the already complex system of nifA regulation in A. caulinodans...
- Virlogeux I, Waxin H, Ecobichon C, Lee J, Popoff M. Characterization of the rcsA and rcsB genes from Salmonella typhi: rcsB through tviA is involved in regulation of Vi antigen synthesis. J Bacteriol. 1996;178:1691-8 pubmed..These results strongly suggest that TviA might act in concert with RcsB at the tviA promoter to activate transcription of the genes involved in Vi polymer synthesis in S. typhi in a Lon-independent manner...
- Francetic O, Pugsley A. The cryptic general secretory pathway (gsp) operon of Escherichia coli K-12 encodes functional proteins. J Bacteriol. 1996;178:3544-9 pubmed..Thus, the gsp operon of E. coli K-12 includes at least two functional genes which, together with the rest of the operon, are probably not expressed under laboratory conditions. ..
- Arsene F, Kaminski P, Elmerich C. Modulation of NifA activity by PII in Azospirillum brasilense: evidence for a regulatory role of the NifA N-terminal domain. J Bacteriol. 1996;178:4830-8 pubmed..We propose a model for the regulation of NifA activity in A. brasilense. ..
- Eiglmeier K, Fsihi H, Heym B, Cole S. On the catalase-peroxidase gene, katG, of Mycobacterium leprae and the implications for treatment of leprosy with isoniazid. FEMS Microbiol Lett. 1997;149:273-8 pubmed..Isoniazid is thus likely to be of no therapeutic benefit to leprosy patients. ..
- Danchin A. Comparison between the Escherichia coli and Bacillus subtilis genomes suggests that a major function of polynucleotide phosphorylase is to synthesize CDP. DNA Res. 1997;4:9-18 pubmed..This article briefly discusses the availability of cytosine nucleotides in eukaryotes, and suggests that they are derived from phospholipids turnover. Finally, the GC content of genomes is discussed in this new light. ..
- Tran Van Nhieu G, Ben Ze ev A, Sansonetti P. Modulation of bacterial entry into epithelial cells by association between vinculin and the Shigella IpaA invasin. EMBO J. 1997;16:2717-29 pubmed publisher..Presumably, IpaA-vinculin interaction initiates the formation of focal adhesion-like structures required for efficient invasion...
- Braun L, Dramsi S, Dehoux P, Bierne H, Lindahl G, Cossart P. InlB: an invasion protein of Listeria monocytogenes with a novel type of surface association. Mol Microbiol. 1997;25:285-94 pubmed..This motif may have important consequences for the release of surface proteins involved in interactions with eukaryotic cells. ..