Experts and Doctors on pregnancy in Rennes, Brittany, France


Locale: Rennes, Brittany, France
Topic: pregnancy

Top Publications

  1. Laugeray A, Herzine A, Perche O, Richard O, Montécot Dubourg C, Menuet A, et al. In utero and lactational exposure to low-doses of the pyrethroid insecticide cypermethrin leads to neurodevelopmental defects in male mice-An ethological and transcriptomic study. PLoS ONE. 2017;12:e0184475 pubmed publisher
  2. Dubourg C, Lazaro L, Pasquier L, Bendavid C, Blayau M, Le Duff F, et al. Molecular screening of SHH, ZIC2, SIX3, and TGIF genes in patients with features of holoprosencephaly spectrum: Mutation review and genotype-phenotype correlations. Hum Mutat. 2004;24:43-51 pubmed
    ..This study confirms the great genetic heterogeneity of the disease, the important phenotypic variability in HPE families, and the difficulty to establish genotype-phenotype correlations. ..
  3. Chevrier C, Perret C, Bahuau M, Zhu H, Nelva A, Herman C, et al. Fetal and maternal MTHFR C677T genotype, maternal folate intake and the risk of nonsyndromic oral clefts. Am J Med Genet A. 2007;143A:248-57 pubmed
    ..The modest sample size limits this study, which nonetheless provides new estimate of the possible impact of dietary folate intake and MTHFR polymorphism on oral clefts. ..
  4. Mercier S, Dubourg C, Garcelon N, Campillo Gimenez B, Gicquel I, Belleguic M, et al. New findings for phenotype-genotype correlations in a large European series of holoprosencephaly cases. J Med Genet. 2011;48:752-60 pubmed publisher
    ..An algorithm is proposed based on these new phenotype-genotype correlations, to facilitate molecular analysis and genetic counselling for HPE. ..
  5. Guibert F, Richard Yris M, Lumineau S, Kotrschal K, Möstl E, Houdelier C. Yolk testosterone levels and offspring phenotype correlate with parental age in a precocial bird. Physiol Behav. 2012;105:242-50 pubmed publisher
    ..Our study shows, for the first time in a bird species, a strong impact of parental age on offspring phenotype, and especially on behaviour, an impact that is possibly mediated via modulation of yolk testosterone content...
  6. Revest M, Minjolle S, Veyer D, Lagathu G, Michelet C, Colimon R. Detection of HHV-6 in over a thousand samples: new types of infection revealed by an analysis of positive results. J Clin Virol. 2011;51:20-4 pubmed publisher
    ..Clinical manifestations of human herpesvirus-6 (HHV-6) have not been clearly defined, and the role of HHV-6 in human disease remains to be fully elucidated...
  7. Le Berre L, Rousse J, Gourraud P, Imbert Marcille B, Salama A, Evanno G, et al. Decrease of blood anti-?1,3 Galactose Abs levels in multiple sclerosis (MS) and clinically isolated syndrome (CIS) patients. Clin Immunol. 2017;180:128-135 pubmed publisher
    ..Since anti-Gal result from an immunization against ?1,3 Gal, lacking in humans but produced in the gut, our data suggest that CIS and MS patients have an altered microbiota or an altered response to this microbiotic epitope. ..
  8. Quelin C, Loget P, Rozel C, D Hervé D, Fradin M, Demurger F, et al. Fetal costello syndrome with neuromuscular spindles excess and p.Gly12Val HRAS mutation. Eur J Med Genet. 2017;60:395-398 pubmed publisher
    ..Gly12Val mutation and severe CS phenotype and points out the importance of a muscle biopsy performed according to the suitable procedure in neuromuscular disorders for any fetal arthrogryposis. ..
  9. Garlantezec R, Warembourg C, Monfort C, Labat L, Pulkkinen J, Bonvallot N, et al. Urinary glycol ether metabolites in women and time to pregnancy: the PELAGIE cohort. Environ Health Perspect. 2013;121:1167-73 pubmed publisher
    ..Glycol ethers are present in a wide range of occupational and domestic products. Animal studies have suggested that some of them may affect ovarian function...

More Information


  1. Chevrier C, Warembourg C, Gaudreau E, Monfort C, Le Blanc A, Guldner L, et al. Organochlorine pesticides, polychlorinated biphenyls, seafood consumption, and time-to-pregnancy. Epidemiology. 2013;24:251-60 pubmed publisher
    ..Our findings were robust in sensitivity analyses, including analysis restricted to primiparous women. These results suggest that PCBs, p,p'-DDE, and other shellfish contaminants may impair human fertility. ..
  2. Cordier S, Garlantezec R, Labat L, Rouget F, Monfort C, Bonvallot N, et al. Exposure during pregnancy to glycol ethers and chlorinated solvents and the risk of congenital malformations. Epidemiology. 2012;23:806-12 pubmed publisher
    ..Exposure to solvents during pregnancy has long been suspected of increasing the risk of congenital malformations, but the lack of prospective assessment of specific solvent exposures has prevented definitive conclusions...
  3. Robert Gangneux F, Murat J, Fricker Hidalgo H, Brenier Pinchart M, Gangneux J, Pelloux H. The placenta: a main role in congenital toxoplasmosis?. Trends Parasitol. 2011;27:530-6 pubmed publisher
    ..Here we argue in favour of placental examination for both diagnostic and epidemiological purposes...
  4. Guivarc h Levêque A, Homer L, Arvis P, Broux P, Moy L, Priou G, et al. Programming in vitro fertilization retrievals during working days after a gonadotropin-releasing hormone antagonist protocol with estrogen pretreatment: does the length of exposure to estradiol impact on controlled ovarian hyperstimulation outcomes?. Fertil Steril. 2011;96:872-6 pubmed publisher
    ..To verify whether a variable number of days beyond the menses of estrogen (E) pretreatment may impact on controlled ovarian hyperstimulation (COH) outcomes and birth rate using a GnRH antagonist protocol...
  5. Aubry F, Mattei M, Barque J, Galibert F. Chromosomal localization and expression pattern of the RNase L inhibitor gene. FEBS Lett. 1996;381:135-9 pubmed
    ..The RLI gene was localized to locus 4q31 by in situ hybridization indicating that this gene and other enzymes of the 2-5A pathway are not organized in cluster in the human genome...
  6. Bendavid C, Dupé V, Rochard L, Gicquel I, Dubourg C, David V. Holoprosencephaly: An update on cytogenetic abnormalities. Am J Med Genet C Semin Med Genet. 2010;154C:86-92 pubmed publisher
    ..The accumulation of recurrent genomic imbalances will lead to the further delineation of minimal critical HPE loci, which is the first step to the identification of new HPE genes...
  7. Cabaret A, Loget P, Loeuillet L, Odent S, Poulain P. Embryology of neural tube defects: information provided by associated malformations. Prenat Diagn. 2007;27:738-42 pubmed
    ..To get information about embryologic mechanisms of neural tube defects (NTD), by studying the associated malformations...
  8. Riffaud L, Ferre J, Carsin Nicol B, Morandi X. Endoscopic third ventriculostomy for the treatment of obstructive hydrocephalus during pregnancy. Obstet Gynecol. 2006;108:801-4 pubmed
  9. Pasquier L, Dubourg C, Gonzales M, Lazaro L, David V, Odent S, et al. First occurrence of aprosencephaly/atelencephaly and holoprosencephaly in a family with a SIX3 gene mutation and phenotype/genotype correlation in our series of SIX3 mutations. J Med Genet. 2005;42:e4 pubmed
  10. Ilyin G, Serandour A, Pigeon C, Rialland M, Glaise D, Guguen Guillouzo C. A new subfamily of structurally related human F-box proteins. Gene. 2002;296:11-20 pubmed
    ..Specifically, FBG2 mRNA was expressed in foetal liver, decreased after birth and re-accumulated in adult liver. Expression of FBG2 was strongly inhibited in hepatoma cells by okadaic acid. ..
  11. Chevrier C, Limon G, Monfort C, Rouget F, Garlantezec R, Petit C, et al. Urinary biomarkers of prenatal atrazine exposure and adverse birth outcomes in the PELAGIE birth cohort. Environ Health Perspect. 2011;119:1034-41 pubmed publisher
    ..Evidence of associations with adverse birth outcomes raises particular concerns for countries where atrazine is still in use. ..
  12. Robert Gangneux F, Gangneux J, Vu N, Jaillard S, Guiguen C, Amiot L. High level of soluble HLA-G in amniotic fluid is correlated with congenital transmission of Toxoplasma gondii. Clin Immunol. 2011;138:129-34 pubmed publisher
    ..05). These data suggest that sHLA-G could participate in immunomodulation necessary to avoid fetal loss due to Toxoplasma infection, but that over-expression could favor congenital transmission. ..
  13. Chevrier C, Bahuau M, Perret C, Iovannisci D, Nelva A, Herman C, et al. Genetic susceptibilities in the association between maternal exposure to tobacco smoke and the risk of nonsyndromic oral cleft. Am J Med Genet A. 2008;146A:2396-406 pubmed publisher
    ..We did not confirm the maternal smoking-infant GSTT1 null interaction previously reported by other investigators. ..