Experts and Doctors on female in Rennes, Brittany, France
Locale: Rennes, Brittany, France
- Gilot D, Migault M, Bachelot L, Journe F, Rogiers A, Donnou Fournet E, et al. A non-coding function of TYRP1 mRNA promotes melanoma growth. Nat Cell Biol. 2017;19:1348-1357 pubmed publisher..Together, our findings assign a pathogenic non-coding function to TYRP1 mRNA and highlight miRNA displacement as a promising targeted therapeutic approach for melanoma. ..
- Nerré A, Bétrémieux P, Nivot Adamiak S. Case Report of Clitoral Hypertrophy in 2 Extremely Premature Girls With an Ovarian Cyst. Pediatrics. 2017;140: pubmed publisher..Drug therapy abstention and clinical and ultrasound monitoring are recommended because spontaneous regression of clitoral hypertrophy seems to be the most common outcome in the literature, as it was in our 2 observations. ..
- Duvergé L, Castelli J, Lizée T, De Crevoisier R, Azria D. [Doses to organs at risk for conformational and stereotactic radiotherapy: Bladder]. Cancer Radiother. 2017;21:597-603 pubmed publisher..In case of conformational radiotherapy of cervix cancer, postoperative endometrium, anal canal and rectum, the recommendations are V40Gy<40% and D2% lower than the prescribed dose. ..
- Bibault J, Dussart S, Pommier P, Morelle M, Huguet M, Boisselier P, et al. Clinical Outcomes of Several IMRT Techniques for Patients With Head and Neck Cancer: A Propensity Score-Weighted Analysis. Int J Radiat Oncol Biol Phys. 2017;99:929-937 pubmed publisher..No significant difference was shown in progression-free and overall survival. These results should be explored in a randomized trial. ..
- Dufies M, Giuliano S, Viotti J, Borchiellini D, Cooley L, Ambrosetti D, et al. CXCL7 is a predictive marker of sunitinib efficacy in clear cell renal cell carcinomas. Br J Cancer. 2017;117:947-953 pubmed publisher..These results were confirmed in a retrospective validation cohort. The levels of CXCL7 did not influence PFS of the bevacizumab-treated patients. CXCL7 may be considered as a predictive marker of sunitinib efficacy for ccRCC patients. ..
- Bergeron A, Chevret S, Granata A, Chevallier P, Vincent L, Huynh A, et al. Effect of Azithromycin on Airflow Decline-Free Survival After Allogeneic Hematopoietic Stem Cell Transplant: The ALLOZITHRO Randomized Clinical Trial. JAMA. 2017;318:557-566 pubmed publisher..The potential for harm related to relapse requires further investigation. clinicaltrials.gov Identifier: NCT01959100. ..
- Auffret V, Lefevre T, Van Belle E, Eltchaninoff H, Iung B, Koning R, et al. Temporal Trends in Transcatheter Aortic Valve Replacement in France: FRANCE 2 to FRANCE TAVI. J Am Coll Cardiol. 2017;70:42-55 pubmed publisher..Registry of Aortic Valve Bioprostheses Established by Catheter [FRANCE TAVI]; NCT01777828). ..
- Lopes R, Alings M, Connolly S, Beresh H, Granger C, Mazuecos J, et al. Rationale and design of the Apixaban for the Reduction of Thrombo-Embolism in Patients With Device-Detected Sub-Clinical Atrial Fibrillation (ARTESiA) trial. Am Heart J. 2017;189:137-145 pubmed publisher..ARTESiA will determine whether oral anticoagulation therapy with apixaban compared with aspirin reduces the risk of stroke or systemic embolism in patients with subclinical AF and additional risk factors. ..
- Davies M, Saiag P, Robert C, Grob J, Flaherty K, Arance A, et al. Dabrafenib plus trametinib in patients with BRAFV600-mutant melanoma brain metastases (COMBI-MB): a multicentre, multicohort, open-label, phase 2 trial. Lancet Oncol. 2017;18:863-873 pubmed publisher..These results provide evidence of clinical benefit with dabrafenib plus trametinib and support the need for additional research to further improve outcomes in patients with melanoma brain metastases. Novartis. ..
- Ducassou S, Leverger G, Fernandes H, Chambost H, Bertrand Y, Armari Alla C, et al. Benefits of rituximab as a second-line treatment for autoimmune haemolytic anaemia in children: a prospective French cohort study. Br J Haematol. 2017;177:751-758 pubmed publisher..All subgroups of patients drew benefit. Our long-term results indicate the baseline to be challenged by new treatment approaches. ..
- Rodon P, Hulin C, Pegourie B, Tiab M, Anglaret B, Benboubker L, et al. Phase II study of bendamustine, bortezomib and dexamethasone as second-line treatment for elderly patients with multiple myeloma: the Intergroupe Francophone du Myelome 2009-01 trial. Haematologica. 2015;100:e56-9 pubmed publisher
- Beaven R, Bastos R, Spanos C, RomÃ© P, Cullen C, Rappsilber J, et al. 14-3-3 regulation of Ncd reveals a new mechanism for targeting proteins to the spindle in oocytes. J Cell Biol. 2017;216:3029-3039 pubmed publisher..Therefore, 14-3-3 translates a spatial cue provided by Aurora B to target Ncd selectively to the spindle within the large volume of oocytes. ..
- Angoulvant F, Bellêttre X, Milcent K, Teglas J, Claudet I, Le Guen C, et al. Effect of Nebulized Hypertonic Saline Treatment in Emergency Departments on the Hospitalization Rate for Acute Bronchiolitis: A Randomized Clinical Trial. JAMA Pediatr. 2017;171:e171333 pubmed publisher..clinicaltrials.gov Identifier: NCT01777347. ..
- Jebrak G, Burgel P, Caillaud D, Deslee G, Brinchault G, Chanez P, et al. [Changing patterns of medication prescription for COPD patients in France. Impact of long-acting muscarinic antagonists' availability]. Rev Mal Respir. 2017;34:535-543 pubmed publisher..The use of long-acting bronchodilators increased from 68 to 80 % between both periods. Vaccinations and rehabilitation remained insufficiently prescribed. LAMA had been added but did not appear to replace other drugs. ..
- Coirier V, Lescoat A, Fournet M, Cazalets C, Coiffier G, Jouneau S, et al. [Screening for pulmonary arterial hypertension in patients with systemic sclerosis: Comparison of DETECT algorithm to decisions of a multidisciplinary team, in a competence centre]. Rev Med Interne. 2017;38:502-507 pubmed publisher..The DETECT algorithm is able to efficiently detect all PAH patients finally diagnosed by our multidisciplinary team. However, it increases by 3 the number of RHC that should be performed. ..
- Auffret V, Becerra Munoz V, Loirat A, Dumont E, Le Breton H, Paradis J, et al. Transcatheter Aortic Valve Implantation Versus Surgical Aortic Valve Replacement in Lower-Surgical-Risk Patients With Chronic Obstructive Pulmonary Disease. Am J Cardiol. 2017;120:1863-1868 pubmed publisher..Future studies should further investigate whether TAVI is associated with reduced respiratory complications, comparing transfemoral TAVI recipients treated with local anesthesia with their SAVR counterparts. ..
- Le Berre L, Rousse J, Gourraud P, Imbert Marcille B, Salama A, Evanno G, et al. Decrease of blood anti-?1,3 Galactose Abs levels in multiple sclerosis (MS) and clinically isolated syndrome (CIS) patients. Clin Immunol. 2017;180:128-135 pubmed publisher..Since anti-Gal result from an immunization against ?1,3 Gal, lacking in humans but produced in the gut, our data suggest that CIS and MS patients have an altered microbiota or an altered response to this microbiotic epitope. ..
- Quelin C, Loget P, Rozel C, D Hervé D, Fradin M, Demurger F, et al. Fetal costello syndrome with neuromuscular spindles excess and p.Gly12Val HRAS mutation. Eur J Med Genet. 2017;60:395-398 pubmed publisher..Gly12Val mutation and severe CS phenotype and points out the importance of a muscle biopsy performed according to the suitable procedure in neuromuscular disorders for any fetal arthrogryposis. ..
- Andrieu S, Guyonnet S, Coley N, Cantet C, Bonnefoy M, Bordes S, et al. Effect of long-term omega 3 polyunsaturated fatty acid supplementation with or without multidomain intervention on cognitive function in elderly adults with memory complaints (MAPT): a randomised, placebo-controlled trial. Lancet Neurol. 2017;16:377-389 pubmed publisher..French Ministry of Health, Pierre Fabre Research Institute, Gerontopole, Exhonit Therapeutics, Avid Radiopharmaceuticals. ..