Genomes and Genes
Experts and Doctors on molecular sequence data in Lyon, Auvergne Rhône Alpes, France
Locale: Lyon, Auvergne Rhône Alpes, France
Topic: molecular sequence data
Publications134 found, 100 shown here
- B hne A, Darras A, D Cotta H, Baroiller J, Galiana Arnoux D, Volff J. The vertebrate makorin ubiquitin ligase gene family has been shaped by large-scale duplication and retroposition from an ancestral gonad-specific, maternal-effect gene. BMC Genomics. 2010;11:721 pubmed publisher..Comparative expression analysis strongly suggests that the ancestral E3 ubiquitin ligase function of the single copy mkrn gene before duplication in vertebrates was gonad-specific, with maternal expression in early embryos...
- Pagès M, Chevret P, Gros Balthazard M, Hughes S, Alcover J, Hutterer R, et al. Paleogenetic analyses reveal unsuspected phylogenetic affinities between mice and the extinct Malpaisomys insularis, an endemic rodent of the Canaries. PLoS ONE. 2012;7:e31123 pubmed publisher..To reconcile molecular and morphological data, we propose to consider Malpaisomys insularis as an insular lineage of mouse. ..
- Hasan U, Zannetti C, Parroche P, Goutagny N, Malfroy M, Roblot G, et al. The human papillomavirus type 16 E7 oncoprotein induces a transcriptional repressor complex on the Toll-like receptor 9 promoter. J Exp Med. 2013;210:1369-87 pubmed publisher..Our studies highlight a novel HPV16-mediated mechanism that combines epigenetic and transcriptional events to suppress a key innate immune sensor...
- Dalla Venezia N, Gilsanz F, Alloisio N, Ducluzeau M, Benz E, Delaunay J. Homozygous 4.1(-) hereditary elliptocytosis associated with a point mutation in the downstream initiation codon of protein 4.1 gene. J Clin Invest. 1992;90:1713-7 pubmed..The ultimate change turned out to be a point mutation of the downstream translation initiation codon (AUG-->AGG). No disorders in other cell types could be related with certainty to the present 4.1(-) HE allele. ..
- Morle L, Roux A, Alloisio N, Pothier B, Starck J, Denoroy L, et al. Two elliptocytogenic alpha I/74 variants of the spectrin alpha I domain. Spectrin Culoz (GGT----GTT; alpha I 40 Gly----Val) and spectrin Lyon (CTT----TTT; alpha I 43 Leu---Phe). J Clin Invest. 1990;86:548-54 pubmed..Variants such as spectrin Culoz and spectrin Lyon should provide insight into a region that participates in spectrin dimer self-association and whose susceptibility to proteolysis must reflect subtle conformational changes. ..
- Rouault J, Falette N, Guéhenneux F, Guillot C, Rimokh R, Wang Q, et al. Identification of BTG2, an antiproliferative p53-dependent component of the DNA damage cellular response pathway. Nat Genet. 1996;14:482-6 pubmed..7). Here, we cloned and localized the human BTG2 gene. We show that BTG2 expression is induced through a p53-dependent mechanism and that BTG2 function may be relevant to cell cycle control and cellular response to DNA damage. ..
- Raffalli Mathieu F, Geneste O, Lang M. Characterization of two nuclear proteins that interact with cytochrome P-450 1A2 mRNA. Regulation of RNA binding and possible role in the expression of the Cyp1a2 gene. Eur J Biochem. 1997;245:17-24 pubmed
- Giry Lozinguez C, Aubert Foucher E, Penin F, Deleage G, Dublet B, van der Rest M. Identification and characterization of a heparin binding site within the NC1 domain of chicken collagen XIV. Matrix Biol. 1998;17:145-9 pubmed..These fragments interact specifically with heparin, which induces an alpha-helical fold with a maximum effect for equimolar heparin/peptide ratio. These data demonstrate the existence of a glycosaminoglycan binding site in NC1. ..
- Prost J, Cozzone A. Detection of an extended-10 element in the promoter region of the pckA gene encoding phosphoenolpyruvate carboxykinase in Escherichia coli. Biochimie. 1999;81:197-200 pubmed..It was concluded that the promoter region of pckA contains an extended -10 module, 5'-TG-3', located one base upstream of the -10 hexamer, which is crucial for transcription. ..
- Honnorat J, Byk T, Kusters I, Aguera M, Ricard D, Rogemond V, et al. Ulip/CRMP proteins are recognized by autoantibodies in paraneoplastic neurological syndromes. Eur J Neurosci. 1999;11:4226-32 pubmed..The identification of the Ulip/CRMP proteins as recognized by anti-CV2 sera should provide new insights into the role of Ulip/CRMPs in oligodendrocytes and into pathophysiology of PND. ..
- Rippert P, Matringe M. Purification and kinetic analysis of the two recombinant arogenate dehydrogenase isoforms of Arabidopsis thaliana. Eur J Biochem. 2002;269:4753-61 pubmed..For both enzymes, steady-state velocity patterns are consistent with a rapid equilibrium, random mechanism in which two dead-end complexes, E-NADPH-arogenate and E-NADP-tyrosine, are formed. ..
- Dubois V, Favre Victoire I, Gebuhrer L. Three new DRB alleles routinely identified by sequence-based typing: DRB1*010103, DRB1*0326 and DRB3*0219. Tissue Antigens. 2004;64:621-3 pubmed..DRB3*0219 differs from DRB3*020201 by two-point mutations at codons 60 and 74 (A/C and A/G, respectively). These mutations at positions 266 and 308 were responsible for two amino acid substitutions (Tyr to Ser and Gln to Arg). ..
- Popa I, Ishikawa D, Tanaka M, Ogino K, Portoukalian J, Taki T. GD3-replica peptides selected from a phage peptide library induce a GD3 ganglioside antibody response. FEBS Lett. 2006;580:1398-404 pubmed..The present data indicate that the immunogenic GD3P4 is processed in a certain size and exposed on the antigen-presenting cells with a molecular shape quite similar to that of the GD3 epitope in 4F6. ..
- Coustham V, Bedet C, Monier K, Schott S, Karali M, Palladino F. The C. elegans HP1 homologue HPL-2 and the LIN-13 zinc finger protein form a complex implicated in vulval development. Dev Biol. 2006;297:308-22 pubmed..We further show by in vivo localization studies that LIN-13 is required for HPL-2 recruitment in nuclear foci. Our data suggest that the LIN-13/HPL-2 complex may physically link a subset of the Rb related synMuv proteins to chromatin. ..
- Reynaud C, Baas D, Gleyzal C, Le Guellec D, Sommer P. Morpholino knockdown of lysyl oxidase impairs zebrafish development, and reflects some aspects of copper metabolism disorders. Matrix Biol. 2008;27:547-60 pubmed publisher..Taken together, these data reveal a role for Lox in early morphogenesis, especially in muscle development and neurogenesis, and resume some aspects of physiopathology of copper metabolism. ..
- Gregoire I, Richetta C, Meyniel Schicklin L, Borel S, Pradezynski F, Diaz O, et al. IRGM is a common target of RNA viruses that subvert the autophagy network. PLoS Pathog. 2011;7:e1002422 pubmed publisher..Our work reveals an unexpected role of IRGM in virus-induced autophagy and suggests that several different families of RNA viruses may use common strategies to manipulate autophagy to improve viral infectivity. ..
- Prudent J, Popgeorgiev N, Bonneau B, Thibaut J, Gadet R, Lopez J, et al. Bcl-wav and the mitochondrial calcium uniporter drive gastrula morphogenesis in zebrafish. Nat Commun. 2013;4:2330 pubmed publisher..Thus, from an evolutionary point of view, the original function of Bcl-2 proteins might have been to contribute in controlling the global positioning system of blastomeres during gastrulation, a critical step in metazoan development. ..
- Rimokh R, Rouault J, Wahbi K, Gadoux M, Lafage M, Archimbaud E, et al. A chromosome 12 coding region is juxtaposed to the MYC protooncogene locus in a t(8;12)(q24;q22) translocation in a case of B-cell chronic lymphocytic leukemia. Genes Chromosomes Cancer. 1991;3:24-36 pubmed..This chromosome 12 coding sequence is conserved in evolution and a transcript of similar size is present in murine tissues. ..
- Deutscher J, Kuster E, Bergstedt U, Charrier V, Hillen W. Protein kinase-dependent HPr/CcpA interaction links glycolytic activity to carbon catabolite repression in gram-positive bacteria. Mol Microbiol. 1995;15:1049-53 pubmed..The sensitivity of this complex formation to phosphorylation of HPr at His-15 also suggests a link between carbon catabolite repression and PTS transport activity. ..
- Ruffet M, Lebrun M, Droux M, Douce R. Subcellular distribution of serine acetyltransferase from Pisum sativum and characterization of an Arabidopsis thaliana putative cytosolic isoform. Eur J Biochem. 1995;227:500-9 pubmed..coli serine acetyltransferase. Since none of the general features of transit peptides could be observed in the N-terminal region of this isoform, we assume that it is a cytosolic form. ..
- Gagliardi D, Breton C, Chaboud A, Vergne P, Dumas C. Expression of heat shock factor and heat shock protein 70 genes during maize pollen development. Plant Mol Biol. 1995;29:841-56 pubmed
- Lacan P, Kister J, Francina A, Souillet G, Galacteros F, Delaunay J, et al. Hemoglobin Debrousse (beta 96[FG3]Leu-->Pro): a new unstable hemoglobin with twofold increased oxygen affinity. Am J Hematol. 1996;51:276-81 pubmed..This electrophoretically neutral hemoglobin was found as a de novo case in a 6-year-old girl suffering from severe anemia with hemolysis and transient aplastic crisis, following infection by parvovirus B19. ..
- Lamartine J, Seri M, Cinti R, Heitzmann F, Creaven M, Radomski N, et al. Molecular cloning and mapping of a human cDNA (PA2G4) that encodes a protein highly homologous to the mouse cell cycle protein p38-2G4. Cytogenet Cell Genet. 1997;78:31-5 pubmed..The deduced amino acid sequence of this human protein shows very strong homology to the mouse protein p38-2G4. The cDNA analyzed probably corresponds to a functional copy found at 12q13. ..
- Lyon M, Leroux C, Greenland T, Chastang J, Patet J, Mornex J. Presence of a unique parainfluenza virus 3 strain identified by RT-PCR in visna-maedi virus infected sheep. Vet Microbiol. 1997;57:95-104 pubmed
- Prost J, Negre D, Cornet Javaux F, Cortay J, Cozzone A, Herbage D, et al. Isolation, cloning, and expression of a new murine zinc finger encoding gene. Biochim Biophys Acta. 1999;1447:278-83 pubmed..These data suggest that ZF-12 might play an important role not only in cartilage differentiation, but also in basic cellular processes. ..
- de Coignac A, Elson G, Delneste Y, Magistrelli G, Jeannin P, Aubry J, et al. Cloning of MMP-26. A novel matrilysin-like proteinase. Eur J Biochem. 2000;267:3323-9 pubmed..Recombinant MMP-26 was produced in mammalian cells and used to demonstrate a proteolytic activity of the enzyme on gelatin and beta-casein. ..
- Corvi R, Berger N, Balczon R, Romeo G. RET/PCM-1: a novel fusion gene in papillary thyroid carcinoma. Oncogene. 2000;19:4236-42 pubmed..However, heterozygosity is retained for seven microsatellite markers in the 8p21-22 region, suggesting that the non-rearranged PCM-1 allele is not lost and that the translocation is balanced. Oncogene (2000) 19, 4236 - 4242 ..
- Chemin I, Zoulim F, Merle P, Arkhis A, Chevallier M, Kay A, et al. High incidence of hepatitis B infections among chronic hepatitis cases of unknown aetiology. J Hepatol. 2001;34:447-54 pubmed..Improved HBV detection tests, which appear mandatory for the diagnosis and management of non-A non-E hepatitis as well as for improved safety of transfusions and transplantations are needed. ..
- Najioullah F, Barlet V, Renaudier P, Guitton C, Crova P, Guerin J, et al. Failure and success of HIV tests for the prevention of HIV-1 transmission by blood and tissue donations. J Med Virol. 2004;73:347-9 pubmed..In contrast, introduction of NAT should be considered to increase tissue donation safety as soon as such screening will be possible technically. ..
- Tong W, Lee M, Galendo D, Wang Z, Sabapathy K. Aflatoxin-B exposure does not lead to p53 mutations but results in enhanced liver cancer of Hupki (human p53 knock-in) mice. Int J Cancer. 2006;119:745-9 pubmed..Furthermore, humanized p53 appears not to be as effective as murine p53 in the mouse cellular environment in preventing malignant transformation. ..
- Szecsi J, Drury R, Josserand V, Grange M, Boson B, Hartl I, et al. Targeted retroviral vectors displaying a cleavage site-engineered hemagglutinin (HA) through HA-protease interactions. Mol Ther. 2006;14:735-44 pubmed..These vectors will allow useful gene transfer applications into target cells exhibiting specific protease activities. ..
- Peyron F, Lobry J, Musset K, Ferrandiz J, Gomez Marin J, Petersen E, et al. Serotyping of Toxoplasma gondii in chronically infected pregnant women: predominance of type II in Europe and types I and III in Colombia (South America). Microbes Infect. 2006;8:2333-40 pubmed..We demonstrated that, despite some limitation due to antigen and/or antibody specificity, serotyping is a promising assay to investigate the relationship between type of strain and severity of the disease. ..
- el Zein L, Ait Lounis A, Morlé L, Thomas J, Chhin B, Spassky N, et al. RFX3 governs growth and beating efficiency of motile cilia in mouse and controls the expression of genes involved in human ciliopathies. J Cell Sci. 2009;122:3180-9 pubmed publisher..In conclusion, RFX proteins not only regulate genes involved in ciliary assembly, but also genes that are involved in ciliary motility and that are associated with ciliopathies such as primary ciliary dyskinesia in humans. ..
- Kremer N, Voronin D, Charif D, Mavingui P, Mollereau B, Vavre F. Wolbachia interferes with ferritin expression and iron metabolism in insects. PLoS Pathog. 2009;5:e1000630 pubmed publisher..By impacting the general physiology of the host, the presence of a symbiont may select for host compensatory mechanisms, which extends the possible consequences of persistent endosymbiont on the evolution of their hosts...
- Molle V, Leiba J, Zanella Cleon I, Becchi M, Kremer L. An improved method to unravel phosphoacceptors in Ser/Thr protein kinase-phosphorylated substrates. Proteomics. 2010;10:3910-5 pubmed publisher..A comparative analysis with a standard method that includes mass spectrometry analysis of in vitro phosphorylated substrates is also addressed. ..
- Blaha D, Arous S, Blériot C, Dorel C, Mandrand Berthelot M, Rodrigue A. The Escherichia coli metallo-regulator RcnR represses rcnA and rcnR transcription through binding on a shared operator site: Insights into regulatory specificity towards nickel and cobalt. Biochimie. 2011;93:434-9 pubmed publisher..In addition to rcnA, RcnR controls expression of its own gene in response to Ni and Co, but the two genes are differentially expressed. ..
- Galmès J, Li Y, Rajoharison A, Ren L, Dollet S, Richard N, et al. Potential implication of new torque teno mini viruses in parapneumonic empyema in children. Eur Respir J. 2013;42:470-9 pubmed publisher..This study reports the description of replicative TTMV-LY isolated from parapneumonic effusions of children hospitalised with PPE, suggesting a potential role of the virus in the pathogenesis of pneumonia. ..
- Sulka B, Lortat Jacob H, Terreux R, Letourneur F, Rousselle P. Tyrosine dephosphorylation of the syndecan-1 PDZ binding domain regulates syntenin-1 recruitment. J Biol Chem. 2009;284:10659-71 pubmed publisher..We propose that tyrosine dephosphorylation of syndecan-1 may regulate its association with cytoskeleton components. ..
- Chassot S, Lambert V, Kay A, Godinot C, Roux B, Trepo C, et al. Fine mapping of neutralization epitopes on duck hepatitis B virus (DHBV) pre-S protein using monoclonal antibodies and overlapping peptides. Virology. 1993;192:217-23 pubmed..To define the amino acids essential for binding to the highly neutralizing Mab 900, we have used single amino acid replacement and demonstrated that two residues Q87 and W88 were important for antibody recognition...
- Bonello J, Opsahl Ferstad H, Perez P, Dumas C, Rogowsky P. Esr genes show different levels of expression in the same region of maize endosperm. Gene. 2000;246:219-27 pubmed
- Herbreteau C, Weill L, Decimo D, Prévôt D, Darlix J, Sargueil B, et al. HIV-2 genomic RNA contains a novel type of IRES located downstream of its initiation codon. Nat Struct Mol Biol. 2005;12:1001-7 pubmed..A combination of translation assays and structural studies reveal that sequences located 50 nucleotides downstream of the AUG codon are crucial for IRES activity...
- Hollstein M, Metcalf R, Welsh J, Montesano R, Harris C. Frequent mutation of the p53 gene in human esophageal cancer. Proc Natl Acad Sci U S A. 1990;87:9958-61 pubmed..The identification of aberrant p53 gene alleles in one-third of the tumors we tested suggests that mutations at this locus are common genetic events in the pathogenesis of squamous cell carcinomas of the esophagus. ..
- Morle L, Morle F, Roux A, Godet J, Forget B, Denoroy L, et al. Spectrin Tunis (Sp alpha I/78), an elliptocytogenic variant, is due to the CGG----TGG codon change (Arg----Trp) at position 35 of the alpha I domain. Blood. 1989;74:828-32 pubmed..The modified proteolytic site, located 25 amino acid residues upstream, occurs at the beginning of the helix. ..
- Hamimes S, Bourgeon D, Stasiak A, Stasiak A, Van Dyck E. Nucleic acid-binding properties of the RRM-containing protein RDM1. Biochem Biophys Res Commun. 2006;344:87-94 pubmed..Based on reported studies of RAD52, we have generated an RDM1 variant mutated in its RD motif. We find that the L119GF --> AAA mutation affects the mode of RDM1 binding to single-stranded DNA. ..
- Guéhenneux F, Duret L, Callanan M, Bouhas R, Hayette S, Berthet C, et al. Cloning of the mouse BTG3 gene and definition of a new gene family (the BTG family) involved in the negative control of the cell cycle. Leukemia. 1997;11:370-5 pubmed..This family is mainly characterized by the presence of two conserved domains (BTG boxes A and B) of as yet undetermined function which are separated by a non-conserved 20-25 amino acid sequence. ..
- Menard A, Monnez C, Estrada de Los Santos P, Segonds C, Caballero Mellado J, LiPuma J, et al. Selection of nitrogen-fixing deficient Burkholderia vietnamiensis strains by cystic fibrosis patients: involvement of nif gene deletions and auxotrophic mutations. Environ Microbiol. 2007;9:1176-85 pubmed..For 17% of B. vietnamiensis clinical strains, CF lungs appeared to have favoured the selection of mutations or deletions leading to N(2)-fixing deficiencies. ..
- Frandi A, Mengoni A, Brilli M. Comparative genomics of VirR regulons in Clostridium perfringens strains. BMC Microbiol. 2010;10:65 pubmed publisher..Main result was that the VirR regulon is variable in different C. perfringens strains with 4 genes controlled in all but one strains and most genes controlled in one or two strains only. ..
- Gibert B, Hadchity E, Czekalla A, Aloy M, Colas P, Rodriguez Lafrasse C, et al. Inhibition of heat shock protein 27 (HspB1) tumorigenic functions by peptide aptamers. Oncogene. 2011;30:3672-81 pubmed publisher..Our data suggest that PAs could provide a potential tool to develop strategies for the discovery of Hsp27 chemical inhibitors. ..
- Bourhis J, Mariano N, Zhao Y, Harlos K, Exposito J, Jones E, et al. Structural basis of fibrillar collagen trimerization and related genetic disorders. Nat Struct Mol Biol. 2012;19:1031-6 pubmed publisher..The results have broad implications for understanding genetic disorders of connective tissues and designing new therapeutic strategies. ..
- Rimokh R, Berger F, Bastard C, Klein B, French M, Archimbaud E, et al. Rearrangement of CCND1 (BCL1/PRAD1) 3' untranslated region in mantle-cell lymphomas and t(11q13)-associated leukemias. Blood. 1994;83:3689-96 pubmed..5 hours) in three t(11q13)-associated cell lines stresses the importance of posttranscriptional derangement in the activation of CCND1. Finally, we did not observe any mutation in the coding frame of the CCND1 cDNA analyzed. ..
- Kremer N, Charif D, Henri H, Bataille M, Prevost G, Kraaijeveld K, et al. A new case of Wolbachia dependence in the genus Asobara: evidence for parthenogenesis induction in Asobara japonica. Heredity (Edinb). 2009;103:248-56 pubmed publisher..Although dependence should lead to co-divergence between Wolbachia and its hosts, the very few cases of co-speciation observed in host-Wolbachia associations question the stability of these obligatory associations. ..
- Atanassov I, Delichère C, Filatov D, Charlesworth D, Negrutiu I, Moneger F. Analysis and evolution of two functional Y-linked loci in a plant sex chromosome system. Mol Biol Evol. 2001;18:2162-8 pubmed..These results suggest that, as for human XY-linked genes, the sex-linked plant loci ceased recombining at different times and reveal distinct events in the evolutionary history of the sex chromosomes. ..
- Buchet Poyau K, Courchet J, Le Hir H, Seraphin B, Scoazec J, Duret L, et al. Identification and characterization of human Mex-3 proteins, a novel family of evolutionarily conserved RNA-binding proteins differentially localized to processing bodies. Nucleic Acids Res. 2007;35:1289-300 pubmed
- Wilmotte R, Marechal J, Morle L, Baklouti F, Philippe N, Kastally R, et al. Low expression allele alpha LELY of red cell spectrin is associated with mutations in exon 40 (alpha V/41 polymorphism) and intron 45 and with partial skipping of exon 46. J Clin Invest. 1993;91:2091-6 pubmed..We hypothesized that the lack of exon 46 would hamper the nucleation process and eventually account for the low expression feature. The present doubly mutated allele was renamed allele alpha LELY (low expression, Lyon). ..
- Geneste O, Raffalli F, Lang M. Identification and characterization of a 44 kDa protein that binds specifically to the 3'-untranslated region of CYP2a5 mRNA: inducibility, subcellular distribution and possible role in mRNA stabilization. Biochem J. 1996;313 ( Pt 3):1029-37 pubmed..We propose that this 44 kDa RNA-binding protein is involved in the stabilization of CYP2a5 mRNA by controlling the length of the poly(A) tail. ..
- Renaud F, Aubel D, Riegel P, Meugnier H, Bollet C. Corynebacterium freneyi sp. nov., alpha-glucosidase-positive strains related to Corynebacterium xerosis. Int J Syst Evol Microbiol. 2001;51:1723-8 pubmed..The name Corynebacterium freneyi sp. nov. is proposed with the type strain ISPB 6695110T (= CIP 106767T = DSM 44506T). ..
- Castro R, Greenland T, Leite R, Gouveia A, Mornex J, Cordier G. Conserved sequence motifs involving the tat reading frame of Brazilian caprine lentiviruses indicate affiliations to both caprine arthritis-encephalitis virus and visna-maedi virus. J Gen Virol. 1999;80 ( Pt 7):1583-9 pubmed..This may be useful for epizoological tracing of the origin of outbreaks...
- Juy M, Penin F, Favier A, Galinier A, Montserret R, Haser R, et al. Dimerization of Crh by reversible 3D domain swapping induces structural adjustments to its monomeric homologue Hpr. J Mol Biol. 2003;332:767-76 pubmed..Our data suggest that reversible 3D domain swapping of Crh might be an efficient regulatory mechanism to modulate its activity. ..
- Grandin N, Charbonneau M. Rvb2/reptin physically associates with telomerase in budding yeast. FEBS Lett. 2011;585:3890-7 pubmed publisher..Finally, we could also isolate RVB2 mutant alleles conferring slight, but stable, telomere shortening. ..
- Pothier J, Prigent Combaret C, Haurat J, Moënne Loccoz Y, Wisniewski Dyé F. Duplication of plasmid-borne nitrite reductase gene nirK in the wheat-associated plant growth-promoting rhizobacterium Azospirillum brasilense Sp245. Mol Plant Microbe Interact. 2008;21:831-42 pubmed publisher..brasilense Sp245 from a distant relative and underwent subsequent duplication; however, both paralogs remained functional and retained their upregulation by the plant partner. ..
- Baldet P, Ruffet M. Biotin synthesis in higher plants: isolation of a cDNA encoding Arabidopsis thaliana bioB-gene product equivalent by functional complementation of a biotin auxotroph mutant bioB105 of Escherichia coli K12. C R Acad Sci III. 1996;319:99-106 pubmed..Furthermore, it does not present a transit peptide in its N-terminal region suggesting that the A. thaliana bioB-gene product reported in this paper is located in the cytosolic compartment. ..
- Vincent C, Doublet P, Grangeasse C, Vaganay E, Cozzone A, Duclos B. Cells of Escherichia coli contain a protein-tyrosine kinase, Wzc, and a phosphotyrosine-protein phosphatase, Wzb. J Bacteriol. 1999;181:3472-7 pubmed..Since these polymers are considered important virulence factors, we suggest that reversible protein phosphorylation on tyrosine may be part of the cascade of reactions that determine the pathogenicity of bacteria. ..
- Scalliet G, Journot N, Jullien F, Baudino S, Magnard J, Channelière S, et al. Biosynthesis of the major scent components 3,5-dimethoxytoluene and 1,3,5-trimethoxybenzene by novel rose O-methyltransferases. FEBS Lett. 2002;523:113-8 pubmed
- Rancès E, Voronin D, Tran Van V, Mavingui P. Genetic and functional characterization of the type IV secretion system in Wolbachia. J Bacteriol. 2008;190:5020-30 pubmed publisher..As VirB6 is known to associate with other VirB proteins to form a membrane-spanning structure, this finding suggests that a T4SS may function in Wolbachia. ..
- Exposito J, Larroux C, Cluzel C, Valcourt U, Lethias C, Degnan B. Demosponge and sea anemone fibrillar collagen diversity reveals the early emergence of A/C clades and the maintenance of the modular structure of type V/XI collagens from sponge to human. J Biol Chem. 2008;283:28226-35 pubmed publisher..This observation is compatible with the suggested primordial function of type V/XI fibrillar collagens in the initiation of the formation of the collagen fibrils...
- Varrin Doyer M, Vincent P, Cavagna S, Auvergnon N, Noraz N, Rogemond V, et al. Phosphorylation of collapsin response mediator protein 2 on Tyr-479 regulates CXCL12-induced T lymphocyte migration. J Biol Chem. 2009;284:13265-76 pubmed publisher..In addition to providing a novel mechanism for T lymphocyte motility, our findings reveal CRMP2 as a transducer of chemokine signaling. ..
- Dimassi S, Labalme A, Ville D, Calender A, Mignot C, Boutry Kryza N, et al. Whole-exome sequencing improves the diagnosis yield in sporadic infantile spasm syndrome. Clin Genet. 2016;89:198-204 pubmed publisher..In addition, we found a possibly pathogenic variant in KIF3C that encodes a kinesin expressed during neural development. Our results confirm that WES improves significantly the diagnosis yield in patients with sporadic ISs. ..
- Rolland N, Job D, Douce R. Common sequence motifs coding for higher-plant and prokaryotic O-acetylserine (thiol)-lyases: bacterial origin of a chloroplast transit peptide?. Biochem J. 1993;293 ( Pt 3):829-33 pubmed
- Penin F, Geourjon C, Montserret R, Bockmann A, Lesage A, Yang Y, et al. Three-dimensional structure of the DNA-binding domain of the fructose repressor from Escherichia coli by 1H and 15N NMR. J Mol Biol. 1997;270:496-510 pubmed..Examination of hydrogen bonds highlights the importance of homologous residues that seem to be conserved for their ability to fulfill helix N and C-capping roles in the LacI repressor family. ..
- Ricard D, Rogemond V, Charrier E, Aguera M, Bagnard D, Belin M, et al. Isolation and expression pattern of human Unc-33-like phosphoprotein 6/collapsin response mediator protein 5 (Ulip6/CRMP5): coexistence with Ulip2/CRMP2 in Sema3a- sensitive oligodendrocytes. J Neurosci. 2001;21:7203-14 pubmed
- Chuzeville S, Puymege A, Madec J, Haenni M, Payot S. Characterization of a new CAMP factor carried by an integrative and conjugative element in Streptococcus agalactiae and spreading in Streptococci. PLoS ONE. 2012;7:e48918 pubmed publisher..This work thus describes a CAMP factor that is carried by a mobile genetic element and has spread to different streptococcal species...
- Douam F, Dao Thi V, Maurin G, Fresquet J, Mompelat D, Zeisel M, et al. Critical interaction between E1 and E2 glycoproteins determines binding and fusion properties of hepatitis C virus during cell entry. Hepatology. 2014;59:776-88 pubmed publisher..Our study highlights the role of E1 as a modulator of HCV binding to receptors and membrane fusion, underlining its potential as an antiviral target...
- Zibara K, Bourdillon M, Chignier E, Covacho C, McGregor J. Identification and cloning of a new gene (2A3-2), homologous to human translational elongation factor, upregulated in a proliferating rat smooth muscle cell line and in carotid hyperplasia. Arterioscler Thromb Vasc Biol. 1999;19:1650-7 pubmed..The 2A3-2 gene, identified in this study, may play a vital role in the cascade of events implicated in switching SMC phenotype from a quiescent to a proliferate one. ..
- Hayette S, Tigaud I, Vanier A, Martel S, Corbo L, Charrin C, et al. AF15q14, a novel partner gene fused to the MLL gene in an acute myeloid leukaemia with a t(11;15)(q23;q14). Oncogene. 2000;19:4446-50 pubmed..Immunofluorescence staining experiments with expression vectors encoding these 85 amino acids confirmed the functionality of the predicted nuclear localization site. ..
- Moreau K, Faure C, Violot S, Gouet P, Verdier G, Ronfort C. Mutational analyses of the core domain of Avian Leukemia and Sarcoma Viruses integrase: critical residues for concerted integration and multimerization. Virology. 2004;318:566-81 pubmed..This study points to the important role of core domain residues in the concerted integration of viral DNA ends as well as in the oligomerization of the enzyme...
- Cortes U, Tong W, Coyle D, Meyer Ficca M, Meyer R, Petrilli V, et al. Depletion of the 110-kilodalton isoform of poly(ADP-ribose) glycohydrolase increases sensitivity to genotoxic and endotoxic stress in mice. Mol Cell Biol. 2004;24:7163-78 pubmed..In addition, these mice were susceptible to streptozotocin-induced diabetes and endotoxic shock. These data indicate that PARG(110) plays an important role in DNA damage responses and in pathological processes. ..
- Hamimes S, Arakawa H, Stasiak A, Kierzek A, Hirano S, Yang Y, et al. RDM1, a novel RNA recognition motif (RRM)-containing protein involved in the cell response to cisplatin in vertebrates. J Biol Chem. 2005;280:9225-35 pubmed..Notably, RDM1 recognizes DNA distortions induced by cisplatin-DNA adducts in vitro. Finally, human RDM1 transcripts are abundant in the testis, suggesting a possible role during spermatogenesis. ..
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