Experts and Doctors on amino acid sequence in Lyon, Auvergne Rhône Alpes, France


Locale: Lyon, Auvergne Rhône Alpes, France
Topic: amino acid sequence

Top Publications

  1. Rouault J, Rimokh R, Tessa C, Paranhos G, Ffrench M, Duret L, et al. BTG1, a member of a new family of antiproliferative genes. EMBO J. 1992;11:1663-70 pubmed
    ..Sequence and Northern blot analyses indicate that BTG1 and PC3 are not cognate genes. We then postulate that these two genes are the first members of a new family of antiproliferative genes. ..
  2. Chenu C, Ibaraki K, Gehron Robey P, Delmas P, Young M. Cloning and sequence analysis of bovine bone sialoprotein cDNA: conservation of acidic domains, tyrosine sulfation consensus repeats, and RGD cell attachment domain. J Bone Miner Res. 1994;9:417-21 pubmed
    ..Northern analysis of RNA from different bovine tissues indicated the presence of BSP message in bone but not in other nonmineralized tissues, confirming that bone is the major site of BSP message production. ..
  3. Legastelois I, Greenland T, Arnaud P, Mornex J, Cordier G. Sequencing of the ovine interleukin-8-encoding cDNA using the polymerase chain reaction. Gene. 1994;150:367-9 pubmed
    ..Identities with other published IL-8 aa sequences are: dog, 91%; pig, 87%; rabbit, 84%; human, 78%; guinea pig, 69%. A 49% aa identity is also found with a chicken embryo fibroblast protein. ..
  4. Rimokh R, Berger F, Bastard C, Klein B, French M, Archimbaud E, et al. Rearrangement of CCND1 (BCL1/PRAD1) 3' untranslated region in mantle-cell lymphomas and t(11q13)-associated leukemias. Blood. 1994;83:3689-96 pubmed
    ..5 hours) in three t(11q13)-associated cell lines stresses the importance of posttranscriptional derangement in the activation of CCND1. Finally, we did not observe any mutation in the coding frame of the CCND1 cDNA analyzed. ..
  5. Rouault J, Samarut C, Duret L, Tessa C, Samarut J, Magaud J. Sequence analysis reveals that the BTG1 anti-proliferative gene is conserved throughout evolution in its coding and 3' non-coding regions. Gene. 1993;129:303-6 pubmed
    ..These data confirm that BTG1 is phylogenetically highly conserved and that BTG1 and PC3/TIS21 may constitute the first members of a new family of functionally related genes. ..
  6. Gagliardi D, Breton C, Chaboud A, Vergne P, Dumas C. Expression of heat shock factor and heat shock protein 70 genes during maize pollen development. Plant Mol Biol. 1995;29:841-56 pubmed
  7. Lethias C, Descollonges Y, Boutillon M, Garrone R. Flexilin: a new extracellular matrix glycoprotein localized on collagen fibrils. Matrix Biol. 1996;15:11-9 pubmed
    ..By reference to its shape as observed by rotary shadowing, we propose the name 'flexilin' for this extracellular matrix glycoprotein. ..
  8. Font B, Eichenberger D, Goldschmidt D, Boutillon M, Hulmes D. Structural requirements for fibromodulin binding to collagen and the control of type I collagen fibrillogenesis--critical roles for disulphide bonding and the C-terminal region. Eur J Biochem. 1998;254:580-7 pubmed
    ..One of these domains could be the C-terminal end of the molecule containing the disulphide loop which is absent in the chymotrypsin-resistant fragment. ..
  9. Juy M, Penin F, Favier A, Galinier A, Montserret R, Haser R, et al. Dimerization of Crh by reversible 3D domain swapping induces structural adjustments to its monomeric homologue Hpr. J Mol Biol. 2003;332:767-76 pubmed
    ..Our data suggest that reversible 3D domain swapping of Crh might be an efficient regulatory mechanism to modulate its activity. ..

More Information

Publications102 found, 100 shown here

  1. Moreau K, Faure C, Violot S, Verdier G, Ronfort C. Mutations in the C-terminal domain of ALSV (Avian Leukemia and Sarcoma Viruses) integrase alter the concerted DNA integration process in vitro. Eur J Biochem. 2003;270:4426-38 pubmed
    ..This study points to the important role of residues at the IN C-terminal domain in the folding and dimerization of the enzyme as well as in the concerted DNA integration of viral DNA ends...
  2. Masse N, Ainouze M, NEEL B, Wild T, Buckland R, Langedijk J. Measles virus (MV) hemagglutinin: evidence that attachment sites for MV receptors SLAM and CD46 overlap on the globular head. J Virol. 2004;78:9051-63 pubmed
  3. Galmarini C, Bouchet B, Audoynaud C, Lamblot C, Falette N, Bertholon J, et al. A p21/WAF1 mutation favors the appearance of drug resistance to paclitaxel in human noncancerous epithelial mammary cells. Int J Cancer. 2006;119:60-6 pubmed
    ..Our data suggest that p21/WAF1 inactivation may confer a strong resistance to paclitaxel in noncancerous breast epithelial cells harboring a p21/WAF1 mutant. ..
  4. Tavtigian S, Samollow P, de Silva D, Thomas A. An analysis of unclassified missense substitutions in human BRCA1. Fam Cancer. 2006;5:77-88 pubmed
  5. Szecsi J, Drury R, Josserand V, Grange M, Boson B, Hartl I, et al. Targeted retroviral vectors displaying a cleavage site-engineered hemagglutinin (HA) through HA-protease interactions. Mol Ther. 2006;14:735-44 pubmed
    ..These vectors will allow useful gene transfer applications into target cells exhibiting specific protease activities. ..
  6. Verlaeten O, Casery C, Cavagna S, Naville D, Giraudon P, Belin M, et al. Identification of Urop11, a novel leptin-modulated gene that is upregulated in the hypothalamus of mice with virus-induced obesity. J Mol Endocrinol. 2007;38:3-17 pubmed
    ..This new gene can be considered a key molecule in the hypothalamic integration pathway and demonstrates the importance of Urop11 as a target of leptin action. ..
  7. Creze C, Castang S, Derivery E, Haser R, Hugouvieux Cotte Pattat N, Shevchik V, et al. The crystal structure of pectate lyase peli from soft rot pathogen Erwinia chrysanthemi in complex with its substrate. J Biol Chem. 2008;283:18260-8 pubmed publisher
    ..However, our study suggests that the catalytic base in PelI is not a conventional arginine but a lysine as proposed in family PL-9. ..
  8. Lazert C, Chazal N, Briant L, Gerlier D, Cortay J. Refined study of the interaction between HIV-1 p6 late domain and ALIX. Retrovirology. 2008;5:39 pubmed publisher
    ..Altogether, our data support a model where the C-terminal proline-rich domain of ALIX allows the access of its binding site to p6 by alleviating a conformational constraint resulting from the presence of the central p6 hinge. ..
  9. Guillemin Y, Lopez J, Gimenez D, Fuertes G, Valero J, Blum L, et al. Active fragments from pro- and antiapoptotic BCL-2 proteins have distinct membrane behavior reflecting their functional divergence. PLoS ONE. 2010;5:e9066 pubmed publisher
    ..BCL-2 family-derived pore-forming helices thus represent structurally analogous, but functionally dissimilar membrane domains. ..
  10. Falah N, Violot S, D cimo D, Berri F, Foucault Grunenwald M, Ohlmann T, et al. Ex vivo and in vivo inhibition of human rhinovirus replication by a new pseudosubstrate of viral 2A protease. J Virol. 2012;86:691-704 pubmed publisher
    ..To our knowledge, this is the first report validating a compound against HRV infection in a mouse model...
  11. Hamadou W, Abed R, Besbes S, Bourdon V, Fabre A, Youssef Y, et al. Familial hematological malignancies: ASXL1 gene investigation. Clin Transl Oncol. 2016;18:385-90 pubmed publisher
    ..This variant should be considered since a potential damaging effect was predicted by in silico analysis, with a view to develop functional assay in order to investigate the biological assessment. ..
  12. Zrhidri A, Jaouad I, Lyahyai J, Raymond L, Egéa G, Taoudi M, et al. Identification of two novel SH3PXD2B gene mutations in Frank-Ter Haar syndrome by exome sequencing: Case report and review of the literature. Gene. 2017;628:190-193 pubmed publisher
    ..Our study shows also, that exome sequencing is a powerful and a cost-effective tool for the diagnosis of a supposed genetically heterogeneous disorder such FTHS. ..
  13. Hamrouni A, Aublin A, Guillaume P, Maryanski J. T cell receptor gene rearrangement lineage analysis reveals clues for the origin of highly restricted antigen-specific repertoires. J Exp Med. 2003;197:601-14 pubmed
    ..Thus, the diversity of TCR-alpha's selected as partners for a given VDJ-beta rearrangement into the mature TCR repertoire may indeed be very limited. ..
  14. Peyron F, Lobry J, Musset K, Ferrandiz J, Gomez Marin J, Petersen E, et al. Serotyping of Toxoplasma gondii in chronically infected pregnant women: predominance of type II in Europe and types I and III in Colombia (South America). Microbes Infect. 2006;8:2333-40 pubmed
    ..We demonstrated that, despite some limitation due to antigen and/or antibody specificity, serotyping is a promising assay to investigate the relationship between type of strain and severity of the disease. ..
  15. Hayette S, Gadoux M, Martel S, Bertrand S, Tigaud I, Magaud J, et al. FLRG (follistatin-related gene), a new target of chromosomal rearrangement in malignant blood disorders. Oncogene. 1998;16:2949-54 pubmed
    ..Besides the t(11;19)-carrying leukemia described in this work, structural rearrangements of the FLRG locus have been found in a non-Hodgkin lymphoma, suggesting that it may play a role in leukemogenesis. ..
  16. Villalba F, Lebrun M, Hua Van A, Daboussi M, Grosjean Cournoyer M. Transposon impala, a novel tool for gene tagging in the rice blast fungus Magnaporthe grisea. Mol Plant Microbe Interact. 2001;14:308-15 pubmed
    ..This gene, called ORP1, is essential for penetration of host leaves by M. grisea and has no sequence homology to known genes. ..
  17. Gabus C, Derrington E, Leblanc P, Chnaiderman J, Dormont D, Swietnicki W, et al. The prion protein has RNA binding and chaperoning properties characteristic of nucleocapsid protein NCP7 of HIV-1. J Biol Chem. 2001;276:19301-9 pubmed
    ..Interestingly, PrP localizes in the membrane and cytoplasm of PrP-expressing cells. These findings suggest that PrP is a multifunctional protein possibly participating in nucleic acid metabolism. ..
  18. Tappaz M, Bitoun M, Reymond I, Sergeant A. Characterization of the cDNA coding for rat brain cysteine sulfinate decarboxylase: brain and liver enzymes are identical proteins encoded by two distinct mRNAs. J Neurochem. 1999;73:903-12 pubmed
    ..Through selective RT-PCR the brain form was detected in brain only, whereas the liver form was found in liver and kidney. These results indicate a tissue-specific regulation of CSD genomic expression. ..
  19. Das S, Cong R, Shandilya J, Senapati P, Moindrot B, Monier K, et al. Characterization of nucleolin K88 acetylation defines a new pool of nucleolin colocalizing with pre-mRNA splicing factors. FEBS Lett. 2013;587:417-24 pubmed publisher
    ..Our findings show that acetylation defines a new pool of nucleolin which support a role for nucleolin in the regulation of mRNA maturation and transcription by RNA polymerase II. ..
  20. de Coignac A, Elson G, Delneste Y, Magistrelli G, Jeannin P, Aubry J, et al. Cloning of MMP-26. A novel matrilysin-like proteinase. Eur J Biochem. 2000;267:3323-9 pubmed
    ..Recombinant MMP-26 was produced in mammalian cells and used to demonstrate a proteolytic activity of the enzyme on gelatin and beta-casein. ..
  21. Hamimes S, Bourgeon D, Stasiak A, Stasiak A, Van Dyck E. Nucleic acid-binding properties of the RRM-containing protein RDM1. Biochem Biophys Res Commun. 2006;344:87-94 pubmed
    ..Based on reported studies of RAD52, we have generated an RDM1 variant mutated in its RD motif. We find that the L119GF --> AAA mutation affects the mode of RDM1 binding to single-stranded DNA. ..
  22. Montagna M, Serova O, Sylla B, Feunteun J, Lenoir G. A 100-kb physical and transcriptional map around the EDH17B2 gene: identification of three novel genes and a pseudogene of a human homologue of the rat PRL-1 tyrosine phosphatase. Hum Genet. 1995;96:532-8 pubmed
    ..They did not reveal striking homologies in database sequence comparison and therefore represent new genes localised on chromosome 17q, in a region that frequently shows loss of heterozigosity in sporadic breast and ovarian cancers. ..
  23. Exposito J, Boute N, Deleage G, Garrone R. Characterization of two genes coding for a similar four-cysteine motif of the amino-terminal propeptide of a sea urchin fibrillar collagen. Eur J Biochem. 1995;234:59-65 pubmed
    ..Curiously, one of these genes lacks the exons coding for four repeats of this motif while, in another gene, the same exons are submitted to an alternative splicing event...
  24. Carulli S, Beck K, Dayan G, Boulesteix S, Lortat Jacob H, Rousselle P. Cell surface proteoglycans syndecan-1 and -4 bind overlapping but distinct sites in laminin ?3 LG45 protein domain. J Biol Chem. 2012;287:12204-16 pubmed publisher
    ..These results suggest that LG45 may trigger different signals toward keratinocytes depending on its interaction with syndecan-1 or -4. ..
  25. Darlix J, Godet J, Ivanyi Nagy R, Fosse P, Mauffret O, Mely Y. Flexible nature and specific functions of the HIV-1 nucleocapsid protein. J Mol Biol. 2011;410:565-81 pubmed publisher
  26. Rippert P, Matringe M. Purification and kinetic analysis of the two recombinant arogenate dehydrogenase isoforms of Arabidopsis thaliana. Eur J Biochem. 2002;269:4753-61 pubmed
    ..For both enzymes, steady-state velocity patterns are consistent with a rapid equilibrium, random mechanism in which two dead-end complexes, E-NADPH-arogenate and E-NADP-tyrosine, are formed. ..
  27. Reynard F, Fatmi A, Verrier B, Bedin F. HIV-1 acute infection env glycomutants designed from 3D model: effects on processing, antigenicity, and neutralization sensitivity. Virology. 2004;324:90-102 pubmed
    ..These results could guide the selection of env mutants with the fewest antigenic and functional alterations but with enhanced neutralization sensitivity. ..
  28. Sheng W, Bouguermouh A, Bouzid M, Djennaoui D, Ooka T. BAMHI DNA fragment H-polymorphism of Epstein-Barr virus is associated with the mutations present in an 89 BP sequence localized in EBNA2 gene. Virus Genes. 2004;29:99-108 pubmed
    ..This suggests that EBV with H1-H2-polymorphism is tightly implicated in NPC development in North Africa rather than EBV with H-polymorphism. ..
  29. Tavtigian S, Deffenbaugh A, Yin L, Judkins T, Scholl T, Samollow P, et al. Comprehensive statistical study of 452 BRCA1 missense substitutions with classification of eight recurrent substitutions as neutral. J Med Genet. 2006;43:295-305 pubmed publisher
    ..For most of these, clinical reclassification will require integrated application of other methods such as pooled family histories, segregation analysis, or validated functional assay...
  30. Lacan P, Kister J, Francina A, Souillet G, Galacteros F, Delaunay J, et al. Hemoglobin Debrousse (beta 96[FG3]Leu-->Pro): a new unstable hemoglobin with twofold increased oxygen affinity. Am J Hematol. 1996;51:276-81 pubmed
    ..This electrophoretically neutral hemoglobin was found as a de novo case in a 6-year-old girl suffering from severe anemia with hemolysis and transient aplastic crisis, following infection by parvovirus B19. ..
  31. B hne A, Zhou Q, Darras A, Schmidt C, Schartl M, Galiana Arnoux D, et al. Zisupton--a novel superfamily of DNA transposable elements recently active in fish. Mol Biol Evol. 2012;29:631-45 pubmed publisher
    ..To conclude, our analysis has uncovered a new superfamily of DNA transposons with potential roles in genome diversity and evolutionary innovation in fish and other organisms...
  32. Castro R, Greenland T, Leite R, Gouveia A, Mornex J, Cordier G. Conserved sequence motifs involving the tat reading frame of Brazilian caprine lentiviruses indicate affiliations to both caprine arthritis-encephalitis virus and visna-maedi virus. J Gen Virol. 1999;80 ( Pt 7):1583-9 pubmed
    ..This may be useful for epizoological tracing of the origin of outbreaks...
  33. Selmi Ruby S, Watrin C, Trouttet Masson S, Bernier Valentin F, Flachon V, Munari Silem Y, et al. The porcine sodium/iodide symporter gene exhibits an uncommon expression pattern related to the use of alternative splice sites not present in the human or murine species. Endocrinology. 2003;144:1074-85 pubmed
    ..Our data show that porcine NIS gene, contrary to the NIS gene from other species, gives rise to splice variants leading to three active and one inactive NIS proteins. ..
  34. Rogemond V, Auger C, Giraudon P, Becchi M, Auvergnon N, Belin M, et al. Processing and nuclear localization of CRMP2 during brain development induce neurite outgrowth inhibition. J Biol Chem. 2008;283:14751-61 pubmed publisher
    ..Therefore, post-transcriptional processing of CRMP2 together with its nuclear localization may be an important key in the regulation of neurite outgrowth in brain development. ..
  35. Vagne Descroix M, Pansu D, Jornvall H, Carlquist M, Guignard H, Jourdan G, et al. Isolation and characterisation of porcine sorbin. Eur J Biochem. 1991;201:53-9 pubmed
    ..No structural similarity was observed with other known proteins in data bases, but several segments have special properties and the C-terminal half is rich in Pro and Arg. ..
  36. Baldet P, Ruffet M. Biotin synthesis in higher plants: isolation of a cDNA encoding Arabidopsis thaliana bioB-gene product equivalent by functional complementation of a biotin auxotroph mutant bioB105 of Escherichia coli K12. C R Acad Sci III. 1996;319:99-106 pubmed
    ..Furthermore, it does not present a transit peptide in its N-terminal region suggesting that the A. thaliana bioB-gene product reported in this paper is located in the cytosolic compartment. ..
  37. Quach T, Mosinger B, Ricard D, Copeland N, Gilbert D, Jenkins N, et al. Collapsin response mediator protein-3/unc-33-like protein-4 gene: organization, chromosomal mapping and expression in the developing mouse brain. Gene. 2000;242:175-82 pubmed
  38. Bardet P, Horard B, Robinson Rechavi M, Laudet V, Vanacker J. Characterization of oestrogen receptors in zebrafish (Danio rerio). J Mol Endocrinol. 2002;28:153-63 pubmed
    ..After 48 h after fertilization, all ERs, but predominantly ER alpha, began to be expressed. We conclude that oestrogen signal transduction can operate during zebrafish development only within discrete time windows. ..
  39. Bardet P, Schubert M, Horard B, Holland L, Laudet V, Holland N, et al. Expression of estrogen-receptor related receptors in amphioxus and zebrafish: implications for the evolution of posterior brain segmentation at the invertebrate-to-vertebrate transition. Evol Dev. 2005;7:223-33 pubmed
  40. Ricard Blum S, Ruggiero F. The collagen superfamily: from the extracellular matrix to the cell membrane. Pathol Biol (Paris). 2005;53:430-42 pubmed
    ..Recent advances in the characterization of proteins containing triple-helical domains but not referred to as collagens are also discussed. ..
  41. Buchet Poyau K, Courchet J, Le Hir H, Seraphin B, Scoazec J, Duret L, et al. Identification and characterization of human Mex-3 proteins, a novel family of evolutionarily conserved RNA-binding proteins differentially localized to processing bodies. Nucleic Acids Res. 2007;35:1289-300 pubmed
  42. Exposito J, Larroux C, Cluzel C, Valcourt U, Lethias C, Degnan B. Demosponge and sea anemone fibrillar collagen diversity reveals the early emergence of A/C clades and the maintenance of the modular structure of type V/XI collagens from sponge to human. J Biol Chem. 2008;283:28226-35 pubmed publisher
    ..This observation is compatible with the suggested primordial function of type V/XI fibrillar collagens in the initiation of the formation of the collagen fibrils...
  43. Besseyre des Horts T, Dumitrescu O, Badiou C, Thomas D, Benito Y, Etienne J, et al. A histidine-to-arginine substitution in Panton-Valentine leukocidin from USA300 community-acquired methicillin-resistant Staphylococcus aureus does not impair its leukotoxicity. Infect Immun. 2010;78:260-4 pubmed publisher
    ..We show here that the H176R variation in the PVL sequence causes no change in leukotoxicity and that the R variant is as efficient as wild-type PVL at inducing pore formation in leukocytes...
  44. Hayette S, Thomas X, Jallades L, Chabane K, Charlot C, Tigaud I, et al. High DNA methyltransferase DNMT3B levels: a poor prognostic marker in acute myeloid leukemia. PLoS ONE. 2012;7:e51527 pubmed publisher
    ..Its quantification should be implemented to the genetic profile used to stratify patients for therapeutical strategies and should be useful to identify patients who may benefit from therapy based on demethylating agents. ..
  45. Dimassi S, Labalme A, Ville D, Calender A, Mignot C, Boutry Kryza N, et al. Whole-exome sequencing improves the diagnosis yield in sporadic infantile spasm syndrome. Clin Genet. 2016;89:198-204 pubmed publisher
    ..In addition, we found a possibly pathogenic variant in KIF3C that encodes a kinesin expressed during neural development. Our results confirm that WES improves significantly the diagnosis yield in patients with sporadic ISs. ..
  46. Cortay J, Negre D, Scarabel M, Ramseier T, Vartak N, Reizer J, et al. In vitro asymmetric binding of the pleiotropic regulatory protein, FruR, to the ace operator controlling glyoxylate shunt enzyme synthesis. J Biol Chem. 1994;269:14885-91 pubmed
    ..It was observed that FruR asymmetrically binds to a 16-base pair DNA sequence located 170 base pairs upstream from the transcriptional start point of the ace operon. ..
  47. Rimokh R, Gadoux M, Bertheas M, Berger F, Garoscio M, Deleage G, et al. FVT-1, a novel human transcription unit affected by variant translocation t(2;18)(p11;q21) of follicular lymphoma. Blood. 1993;81:136-42 pubmed
    ..The proximity of FVT-1 to the BCL-2 locus suggests that in the t(14;18) currently observed in follicular lymphomas, both genes would participate in the tumoral process. ..
  48. Ravanel S, Ruffet M, Douce R. Cloning of an Arabidopsis thaliana cDNA encoding cystathionine beta-lyase by functional complementation in Escherichia coli. Plant Mol Biol. 1995;29:875-82 pubmed
    ..Southern blot analysis suggested that cystathionine beta-lyase is encoded by a single copy gene in A. thaliana. ..
  49. Honnorat J, Byk T, Kusters I, Aguera M, Ricard D, Rogemond V, et al. Ulip/CRMP proteins are recognized by autoantibodies in paraneoplastic neurological syndromes. Eur J Neurosci. 1999;11:4226-32 pubmed
    ..The identification of the Ulip/CRMP proteins as recognized by anti-CV2 sera should provide new insights into the role of Ulip/CRMPs in oligodendrocytes and into pathophysiology of PND. ..
  50. Birot A, Duret L, Bartholin L, Santalucia B, Tigaud I, Magaud J, et al. Identification and molecular analysis of BANP. Gene. 2000;253:189-96 pubmed
  51. Paris S, Wessel P, Dumas R. Overproduction, purification, and characterization of recombinant aspartate semialdehyde dehydrogenase from Arabidopsis thaliana. Protein Expr Purif. 2002;24:99-104 pubmed
    ..The plant enzyme exhibited a specific activity of 26 micromol NADPH oxidized min(-1) mg(-1) of protein with a K(M) value for NADPH of 92 microM. ASDH showed cooperative behavior for aspartyl phosphate with a K(0.5) value of 37 microM. ..
  52. Bonnaud B, Bouton O, Oriol G, Cheynet V, Duret L, Mallet F. Evidence of selection on the domesticated ERVWE1 env retroviral element involved in placentation. Mol Biol Evol. 2004;21:1895-901 pubmed publisher
    ..The identification of selective constraints on env ERVWE1 confirms that this retroviral locus has been recruited in the hominoid lineage to become a bona fide gene...
  53. Coustham V, Bedet C, Monier K, Schott S, Karali M, Palladino F. The C. elegans HP1 homologue HPL-2 and the LIN-13 zinc finger protein form a complex implicated in vulval development. Dev Biol. 2006;297:308-22 pubmed
    ..We further show by in vivo localization studies that LIN-13 is required for HPL-2 recruitment in nuclear foci. Our data suggest that the LIN-13/HPL-2 complex may physically link a subset of the Rb related synMuv proteins to chromatin. ..
  54. Grangeasse C, Cozzone A, Deutscher J, Mijakovic I. Tyrosine phosphorylation: an emerging regulatory device of bacterial physiology. Trends Biochem Sci. 2007;32:86-94 pubmed
  55. Varrin Doyer M, Vincent P, Cavagna S, Auvergnon N, Noraz N, Rogemond V, et al. Phosphorylation of collapsin response mediator protein 2 on Tyr-479 regulates CXCL12-induced T lymphocyte migration. J Biol Chem. 2009;284:13265-76 pubmed publisher
    ..In addition to providing a novel mechanism for T lymphocyte motility, our findings reveal CRMP2 as a transducer of chemokine signaling. ..
  56. Grandin N, Charbonneau M. Rvb2/reptin physically associates with telomerase in budding yeast. FEBS Lett. 2011;585:3890-7 pubmed publisher
    ..Finally, we could also isolate RVB2 mutant alleles conferring slight, but stable, telomere shortening. ..
  57. Morle L, Roux A, Alloisio N, Pothier B, Starck J, Denoroy L, et al. Two elliptocytogenic alpha I/74 variants of the spectrin alpha I domain. Spectrin Culoz (GGT----GTT; alpha I 40 Gly----Val) and spectrin Lyon (CTT----TTT; alpha I 43 Leu---Phe). J Clin Invest. 1990;86:548-54 pubmed
    ..Variants such as spectrin Culoz and spectrin Lyon should provide insight into a region that participates in spectrin dimer self-association and whose susceptibility to proteolysis must reflect subtle conformational changes. ..
  58. Chassot S, Lambert V, Kay A, Godinot C, Roux B, Trepo C, et al. Fine mapping of neutralization epitopes on duck hepatitis B virus (DHBV) pre-S protein using monoclonal antibodies and overlapping peptides. Virology. 1993;192:217-23 pubmed
    ..To define the amino acids essential for binding to the highly neutralizing Mab 900, we have used single amino acid replacement and demonstrated that two residues Q87 and W88 were important for antibody recognition...
  59. Blond J, Beseme F, Duret L, Bouton O, Bedin F, Perron H, et al. Molecular characterization and placental expression of HERV-W, a new human endogenous retrovirus family. J Virol. 1999;73:1175-85 pubmed
    ..1-, and 1.3-kb transcripts was observed, and a putative splicing strategy was described. The apparently tissue-restricted HERV-W long terminal repeat expression is discussed with respect to physiological and pathological contexts. ..
  60. Zibara K, Bourdillon M, Chignier E, Covacho C, McGregor J. Identification and cloning of a new gene (2A3-2), homologous to human translational elongation factor, upregulated in a proliferating rat smooth muscle cell line and in carotid hyperplasia. Arterioscler Thromb Vasc Biol. 1999;19:1650-7 pubmed
    ..The 2A3-2 gene, identified in this study, may play a vital role in the cascade of events implicated in switching SMC phenotype from a quiescent to a proliferate one. ..
  61. Baron T, Madec J, Calavas D. Similar signature of the prion protein in natural sheep scrapie and bovine spongiform encephalopathy-linked diseases. J Clin Microbiol. 1999;37:3701-4 pubmed
    ..Overall results suggest that scrapie cases with features similar to those of BSE could be found more frequently in sheep than previously described...
  62. Hayette S, Tigaud I, Vanier A, Martel S, Corbo L, Charrin C, et al. AF15q14, a novel partner gene fused to the MLL gene in an acute myeloid leukaemia with a t(11;15)(q23;q14). Oncogene. 2000;19:4446-50 pubmed
    ..Immunofluorescence staining experiments with expression vectors encoding these 85 amino acids confirmed the functionality of the predicted nuclear localization site. ..
  63. Eugster A, Pécheur E, Michel F, Winsor B, Letourneur F, Friant S. Ent5p is required with Ent3p and Vps27p for ubiquitin-dependent protein sorting into the multivesicular body. Mol Biol Cell. 2004;15:3031-41 pubmed
    ..Therefore, Ent3p and Ent5p are the first proteins shown to be connectors between PtdIns(3,5)P(2)- and the Vps27p-ubiquitin-driven sorting machinery at the multivesicular body. ..
  64. Exposito J, Suzuki H, Geourjon C, Garrone R, Solursh M, Ramirez F. Identification of a cell lineage-specific gene coding for a sea urchin alpha 2(IV)-like collagen chain. J Biol Chem. 1994;269:13167-71 pubmed
    ..Finally, in situ hybridizations revealed that expression of this collagen gene is restricted to the mesenchyme cell lineage of the developing sea urchin embryo...
  65. Wilmotte R, Marechal J, Morle L, Baklouti F, Philippe N, Kastally R, et al. Low expression allele alpha LELY of red cell spectrin is associated with mutations in exon 40 (alpha V/41 polymorphism) and intron 45 and with partial skipping of exon 46. J Clin Invest. 1993;91:2091-6 pubmed
    ..We hypothesized that the lack of exon 46 would hamper the nucleation process and eventually account for the low expression feature. The present doubly mutated allele was renamed allele alpha LELY (low expression, Lyon). ..
  66. Franc S, Marzin E, Boutillon M, Lafont R, Lechene de la Porte P, Herbage D. Immunohistochemical and biochemical analyses of 20,000-25,000-year-old fossil cartilage. Eur J Biochem. 1995;234:125-31 pubmed
    ..These results confirm the cartilaginous nature of the sample and the preservation of tissue-specific components, and suggest that the process of fossilization is closely related to a mechanism of phosphatization. ..
  67. Fischer C, Geourjon C, Bourson C, Deutscher J. Cloning and characterization of the Bacillus subtilis prkA gene encoding a novel serine protein kinase. Gene. 1996;168:55-60 pubmed
    ..After expression of prkA and purification of PrkA, we could demonstrate that PrkA can indeed phosphorylate a Bs 60-kDa protein at a Ser residue. ..
  68. Leroux C, Chastang J, Greenland T, Mornex J. Genomic heterogeneity of small ruminant lentiviruses: existence of heterogeneous populations in sheep and of the same lentiviral genotypes in sheep and goats. Arch Virol. 1997;142:1125-37 pubmed
    ..A phylogenetic tree of pol gene sequences confirmed the presence of a novel genotype of SRLV in France...
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    ..An evolutionary scenario is proposed in which phylogenetic relationships of the alpha chains of fibrillar collagens of vertebrates could be related to Hox cluster history. ..
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    ..In addition, these mice were susceptible to streptozotocin-induced diabetes and endotoxic shock. These data indicate that PARG(110) plays an important role in DNA damage responses and in pathological processes. ..
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    ..Notably, RDM1 recognizes DNA distortions induced by cisplatin-DNA adducts in vitro. Finally, human RDM1 transcripts are abundant in the testis, suggesting a possible role during spermatogenesis. ..
  73. Hiriart E, Gruffat H, Buisson M, Mikaelian I, Keppler S, Meresse P, et al. Interaction of the Epstein-Barr virus mRNA export factor EB2 with human Spen proteins SHARP, OTT1, and a novel member of the family, OTT3, links Spen proteins with splicing regulation and mRNA export. J Biol Chem. 2005;280:36935-45 pubmed
    ..Thus our results suggested a new function for Spen proteins related to mRNA export and splicing. ..
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    ..Taken together, these data reveal a role for Lox in early morphogenesis, especially in muscle development and neurogenesis, and resume some aspects of physiopathology of copper metabolism. ..
  75. Pothier J, Prigent Combaret C, Haurat J, Moënne Loccoz Y, Wisniewski Dyé F. Duplication of plasmid-borne nitrite reductase gene nirK in the wheat-associated plant growth-promoting rhizobacterium Azospirillum brasilense Sp245. Mol Plant Microbe Interact. 2008;21:831-42 pubmed publisher
    ..brasilense Sp245 from a distant relative and underwent subsequent duplication; however, both paralogs remained functional and retained their upregulation by the plant partner. ..
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    ..Urinary alpha/betaCTX ratio has been proposed to reflect collagen maturation. We investigated changes in bone turnover and Col I isomerization in adult patients with OI and their relationship with Col I gene mutations...
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    ..Taken together, our results identify a new TGF? regulatory layer, whereby sumoylation strengthens the TIF1? repressive action on canonical TGF? signaling. ..
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    ..Thus, from an evolutionary point of view, the original function of Bcl-2 proteins might have been to contribute in controlling the global positioning system of blastomeres during gastrulation, a critical step in metazoan development. ..
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    ..This family is mainly characterized by the presence of two conserved domains (BTG boxes A and B) of as yet undetermined function which are separated by a non-conserved 20-25 amino acid sequence. ..
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    ..This is an example of the identification of the activity of an unknown protein through direct sequence work. Some of the parsley HPR physicochemical and kinetic properties are similar to those of the cucumber enzyme. ..
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    ..Since these polymers are considered important virulence factors, we suggest that reversible protein phosphorylation on tyrosine may be part of the cascade of reactions that determine the pathogenicity of bacteria. ..
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    ..Although the existence of other cell interaction sites is likely in this huge molecule, these similar patterns of adhesion and inhibition suggest that the fibrinogen domain might be a dominant site in the whole molecule. ..
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    ..These data suggest that ZF-12 might play an important role not only in cartilage differentiation, but also in basic cellular processes. ..
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    ..PLK1 is a proviral host factor that could be envisaged as a target for combined antiviral and antitumoral strategies against HBV infection and HBV-mediated carcinogenesis. (Hepatology 2017;66:1750-1765). ..
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    ..coli serine acetyltransferase. Since none of the general features of transit peptides could be observed in the N-terminal region of this isoform, we assume that it is a cytosolic form. ..
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    ..Examination of hydrogen bonds highlights the importance of homologous residues that seem to be conserved for their ability to fulfill helix N and C-capping roles in the LacI repressor family. ..
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    ..Overall, these data indicate that modulation by steric exclusion of cell adhesion to a KKTR-dependent cell adhesive site present within the N-terminal domain of TSP could explain the antiadhesive properties of DCN. ..
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    ..lipoferum 4B. This is the first synteny, phylogenetic, and functional analysis of factors modulating acdS expression in Azospirillum plant growth-promoting rhizobacterium...
  91. Catena R, Escoffier E, Caron C, Khochbin S, Martianov I, Davidson I. HMGB4, a novel member of the HMGB family, is preferentially expressed in the mouse testis and localizes to the basal pole of elongating spermatids. Biol Reprod. 2009;80:358-66 pubmed publisher
    ..These results show that HMGB4 and H1FNT specify distinct chromatin domains at the apical and basal poles of the elongating spermatid nucleus...
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    ..This work thus describes a CAMP factor that is carried by a mobile genetic element and has spread to different streptococcal species...