Genomes and Genes
Experts and Doctors on animals in Bordeaux, Aquitaine Limousin Poitou Charentes, France
Locale: Bordeaux, Aquitaine Limousin Poitou Charentes, France
Publications272 found, 100 shown here
- Chetrit J, Ballion B, Laquitaine S, Belujon P, Morin S, Taupignon A, et al. Involvement of Basal Ganglia network in motor disabilities induced by typical antipsychotics. PLoS ONE. 2009;4:e6208 pubmed publisher..We provide new insight into the key role of GP in the pathophysiology of APD-induced EPS suggesting that the GP can be considered as a potential target for the treatment of EPS. ..
- Vendruscolo L, Gueye A, Darnaudéry M, Ahmed S, Cador M. Sugar overconsumption during adolescence selectively alters motivation and reward function in adult rats. PLoS ONE. 2010;5:e9296 pubmed publisher..Sugar overconsumption induces a developmental stage-specific chronic depression in reward processing that may contribute to an increase in the vulnerability to reward-related psychiatric disorders. ..
- Arnou B, Dahout Gonzalez C, Pelosi L, Lauquin G, Brandolin G, Trezeguet V. Native membrane proteins vs. yeast recombinant: an example: the mitochondrial ADP/ATP carrier. Methods Mol Biol. 2010;654:19-28 pubmed publisher..We show that, as expected, length and position of the tag are important criteria for qualitative purification. We also discuss the advantages and drawbacks of purifying Ancp either from a natural source or from engineered yeast cells. ..
- Rezvani H, Ali N, Serrano Sanchez M, Dubus P, Varon C, Ged C, et al. Loss of epidermal hypoxia-inducible factor-1? accelerates epidermal aging and affects re-epithelialization in human and mouse. J Cell Sci. 2011;124:4172-83 pubmed publisher..Overall, these results indicate a role of HIF-1? in skin homeostasis especially during epidermal aging. ..
- Brossaud J, Roumes H, Moisan M, Pallet V, Redonnet A, Corcuff J. Retinoids and glucocorticoids target common genes in hippocampal HT22 cells. J Neurochem. 2013;125:518-31 pubmed publisher..In conclusion, GC and RA both interact through regulations of the two receptors, RAR? and GR. Furthermore, they both act, synergistically or oppositely, on other target proteins critical for neuronal plasticity, tTG and BDNF. ..
- von Uckermann G, Le Ray D, Combes D, Straka H, Simmers J. Spinal efference copy signaling and gaze stabilization during locomotion in juvenile Xenopus frogs. J Neurosci. 2013;33:4253-64 pubmed publisher..Thus, adaptive developmental plasticity during metamorphosis enables spinal CPG-driven extraocular motor activity to match the changing requirements for eye movement control during self-motion. ..
- Courtin J, Chaudun F, Rozeske R, Karalis N, Gonzalez Campo C, Wurtz H, et al. Prefrontal parvalbumin interneurons shape neuronal activity to drive fear expression. Nature. 2014;505:92-6 pubmed publisher..Our results identify two complementary neuronal mechanisms mediated by PVINs that precisely coordinate and enhance the neuronal activity of prefrontal projection neurons to drive fear expression. ..
- Marty V, Medina C, Combe C, Parnet P, Amédée T. ATP binding cassette transporter ABC1 is required for the release of interleukin-1beta by P2X7-stimulated and lipopolysaccharide-primed mouse Schwann cells. Glia. 2005;49:511-9 pubmed..Furthermore, ABC1 transporters could be a target of therapeutic interest for regulating IL-1beta activity in neuroinflammation disorders...
- Pasdois P, Beauvoit B, Tariosse L, Vinassa B, Bonoron Adele S, Dos Santos P. Effect of diazoxide on flavoprotein oxidation and reactive oxygen species generation during ischemia-reperfusion: a study on Langendorff-perfused rat hearts using optic fibers. Am J Physiol Heart Circ Physiol. 2008;294:H2088-97 pubmed publisher..In conclusion, the diazoxide-mediated cardioprotection is supported by a moderate H(2)O(2) production during the preconditioning phase and a strong decrease in oxidant generation during the subsequent ischemic and reperfusion phases. ..
- Fernagut P, Li Q, Dovero S, Chan P, Wu T, Ravenscroft P, et al. Dopamine transporter binding is unaffected by L-DOPA administration in normal and MPTP-treated monkeys. PLoS ONE. 2010;5:e14053 pubmed publisher..Thus, results of these studies may have been affected by factors other than the primary biological process investigated...
- Retailleau A, Etienne S, Guthrie M, Boraud T. Where is my reward and how do I get it? Interaction between the hippocampus and the basal ganglia during spatial learning. J Physiol Paris. 2012;106:72-80 pubmed publisher..Each of the three loops serves a different aspect of spatial decision making and all three are linked by their mutual connections and are under the control of the dopaminergic learning signal. ..
- Kechkar A, Nair D, Heilemann M, Choquet D, Sibarita J. Real-time analysis and visualization for single-molecule based super-resolution microscopy. PLoS ONE. 2013;8:e62918 pubmed publisher..Automatic feedback control ensures optimal molecule density throughout the acquisition process. With this method, we significantly improve the efficiency and feasibility of localization-based super-resolution microscopy. ..
- Martin A, Salvador F, Moreno Bueno G, Floristán A, Ruiz Herguido C, Cuevas E, et al. Lysyl oxidase-like 2 represses Notch1 expression in the skin to promote squamous cell carcinoma progression. EMBO J. 2015;34:1090-109 pubmed publisher..Our data identify for the first time novel LOXL2 roles in tissue homeostasis and support it as a target for SCC therapy. ..
- Dumas De La Roque E, Smeralda G, Quignard J, Freund Michel V, Courtois A, Marthan R, et al. Altered vasoreactivity in neonatal rats with pulmonary hypertension associated with bronchopulmonary dysplasia: Implication of both eNOS phosphorylation and calcium signaling. PLoS ONE. 2017;12:e0173044 pubmed publisher..Reduced activating eNOS phosphorylation and enhanced Ca2+ signaling likely account for alterations of pulmonary arterial reactivity. ..
- Robert Richard E, Moreau Gaudry F, Lalanne M, Lamrissi Garcia I, Cario Andre M, Guyonnet Duperat V, et al. Effective gene therapy of mice with congenital erythropoietic porphyria is facilitated by a survival advantage of corrected erythroid cells. Am J Hum Genet. 2008;82:113-24 pubmed publisher..These results demonstrate that the cure of this mouse model of CEP at a moderate transduction level supports the proof of concept of a gene therapy in this disease by transplantation of genetically modified hematopoietic stem cells. ..
- Rottiers P, Saltel F, Daubon T, Chaigne Delalande B, Tridon V, Billottet C, et al. TGFbeta-induced endothelial podosomes mediate basement membrane collagen degradation in arterial vessels. J Cell Sci. 2009;122:4311-8 pubmed publisher..We propose that podosome rosettes are involved in arterial vessel remodeling. ..
- Moreau M, Piguel N, Papouin T, Koehl M, Durand C, Rubio M, et al. The planar polarity protein Scribble1 is essential for neuronal plasticity and brain function. J Neurosci. 2010;30:9738-52 pubmed publisher..Our data identify Scrib1 as a crucial regulator of brain development and spine morphology, and suggest that Scrib1(crc/+) mice might be a model for studying synaptic dysfunction and human psychiatric disorders. ..
- Nargeot R, Simmers J. Neural mechanisms of operant conditioning and learning-induced behavioral plasticity in Aplysia. Cell Mol Life Sci. 2011;68:803-16 pubmed publisher..Aplysia therefore continues to provide a model system for understanding learning and memory formation that enables establishing the neurobiological links between behavioral, network, and cellular levels of analysis. ..
- Bouchecareilh M, Higa A, Fribourg S, Moenner M, Chevet E. Peptides derived from the bifunctional kinase/RNase enzyme IRE1? modulate IRE1? activity and protect cells from endoplasmic reticulum stress. FASEB J. 2011;25:3115-29 pubmed publisher..4-fold in cells expressing this peptide. Hence, targeted and selective activation of the catalytic properties of IRE1? may consequently define new strategies to protect cells from deleterious effects of ER stress signaling. ..
- Dubreucq S, Durand A, Matias I, Benard G, Richard E, Soria Gomez E, et al. Ventral tegmental area cannabinoid type-1 receptors control voluntary exercise performance. Biol Psychiatry. 2013;73:895-903 pubmed publisher..These results position the endocannabinoid control of inhibitory transmission as a prerequisite for wheel-running performance in mice. ..
- Ammar Z, Plazolles N, Baltz T, Coustou V. Identification of trans-sialidases as a common mediator of endothelial cell activation by African trypanosomes. PLoS Pathog. 2013;9:e1003710 pubmed publisher..b. brucei. The corresponding TS were characterized and shown to activate endothelial cells, suggesting that TS represent a common mediator of endothelium activation among trypanosome species with divergent physiopathologies. ..
- Ducassou S, Prouzet Mauleon V, Deau M, Brunet de la Grange P, Cardinaud B, Soueidan H, et al. MYB-GATA1 fusion promotes basophilic leukaemia: involvement of interleukin-33 and nerve growth factor receptors. J Pathol. 2017;242:347-357 pubmed publisher..Our results highlight the role of IL-33 and NGF receptors in the basophilic differentiation of normal and leukaemic cells. Copyright © 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. ..
- Bureau I, Bischoff S, Heinemann S, Mulle C. Kainate receptor-mediated responses in the CA1 field of wild-type and GluR6-deficient mice. J Neurosci. 1999;19:653-63 pubmed..These results indicate that in CA1 pyramidal cells, distinct subtypes of kainate receptors mediate several functionally antagonistic effects. ..
- Laharie D, Menard S, Asencio C, Vidal Martinez T, Rullier A, Zerbib F, et al. Effect of rebamipide on the colonic barrier in interleukin-10-deficient mice. Dig Dis Sci. 2007;52:84-92 pubmed..These properties could be helpful in the management of some inflammatory bowel diseases. ..
- Groc L, Choquet D, Stephenson F, Verrier D, Manzoni O, Chavis P. NMDA receptor surface trafficking and synaptic subunit composition are developmentally regulated by the extracellular matrix protein Reelin. J Neurosci. 2007;27:10165-75 pubmed..Our data reveal a new mode of control of synaptic NMDAR assembly at postnatal hippocampal synapses and an unprecedented role of ECM proteins in regulating glutamate receptor surface diffusion. ..
- Pinheiro P, Mulle C. Presynaptic glutamate receptors: physiological functions and mechanisms of action. Nat Rev Neurosci. 2008;9:423-36 pubmed publisher..Furthermore, we discuss the physiological conditions that are necessary for their activation, the source of the glutamate that activates them, their mechanisms of action and their involvement in higher brain function. ..
- Dausse E, Da Rocha Gomes S, Toulmé J. Aptamers: a new class of oligonucleotides in the drug discovery pipeline?. Curr Opin Pharmacol. 2009;9:602-7 pubmed publisher..Aptamers constitute promising molecules for therapeutic applications as exemplified by pegaptanib, an aptamer-derived anti-VEGF compound shown to be effective in treating age-related macular degeneration. ..
- Giannone G, Hosy E, Levet F, Constals A, Schulze K, Sobolevsky A, et al. Dynamic superresolution imaging of endogenous proteins on living cells at ultra-high density. Biophys J. 2010;99:1303-10 pubmed publisher..We show here that the unprecedented large statistics obtained by uPAINT on single cells reveal local diffusion properties of specific proteins, either in distinct membrane compartments of adherent cells or in neuronal synapses. ..
- Favereaux A, Thoumine O, Bouali Benazzouz R, Roques V, Papon M, Salam S, et al. Bidirectional integrative regulation of Cav1.2 calcium channel by microRNA miR-103: role in pain. EMBO J. 2011;30:3830-41 pubmed publisher..Moreover, we demonstrate that miR-103 is down-regulated in neuropathic animals and that miR-103 intrathecal applications successfully relieve pain, identifying miR-103 as a novel possible therapeutic target in neuropathic chronic pain. ..
- Carta M, Opazo P, Veran J, Athane A, Choquet D, Coussen F, et al. CaMKII-dependent phosphorylation of GluK5 mediates plasticity of kainate receptors. EMBO J. 2013;32:496-510 pubmed publisher..We propose that CaMKII-dependent phosphorylation of GluK5 is responsible for synaptic depression by untrapping of KARs from the PSD and increased diffusion away from synaptic sites. ..
- Daburon S, Devaud C, Costet P, Morello A, Garrigue Antar L, Maillasson M, et al. Functional characterization of a chimeric soluble Fas ligand polymer with in vivo anti-tumor activity. PLoS ONE. 2013;8:e54000 pubmed publisher..Therefore, the optimization of the FasL conformation has to be considered for the development of efficient FasL-derived anti-cancer drugs targeting Fas. ..
- Guthrie M, Leblois A, Garenne A, Boraud T. Interaction between cognitive and motor cortico-basal ganglia loops during decision making: a computational study. J Neurophysiol. 2013;109:3025-40 pubmed publisher..As learning progresses, the action selection becomes based on learned visual cue values and is not interfered with by the noise that was necessary before learning. ..
- Fessart D, Marza E, Taouji S, Delom F, Chevet E. P97/CDC-48: proteostasis control in tumor cell biology. Cancer Lett. 2013;337:26-34 pubmed publisher..Moreover p97/CDC-48 inhibitors were developed and are currently under intense investigation as anticancer drugs. Herein, we discuss the role of p97/CDC-48 in cancer development and its therapeutic potential in tumor cell biology. ..
- Currie S, Combes D, Scott N, Simmers J, Sillar K. A behaviorally related developmental switch in nitrergic modulation of locomotor rhythmogenesis in larval Xenopus tadpoles. J Neurophysiol. 2016;115:1446-57 pubmed publisher..Finally, NO's activation of neurons in the brain stem also leads to the release of NO in the spinal cord that subsequently contributes to NO's facilitation of swimming. ..
- Mazurier F, Fontanellas A, Salesse S, Taine L, Landriau S, Moreau Gaudry F, et al. A novel immunodeficient mouse model--RAG2 x common cytokine receptor gamma chain double mutants--requiring exogenous cytokine administration for human hematopoietic stem cell engraftment. J Interferon Cytokine Res. 1999;19:533-41 pubmed..This unique feature of the RAG2-/-/gamma c- mouse model should be particularly well suited for assessing the role of different cytokines in human lymphopoiesis and stem/progenitor cell function in vivo. ..
- Frenois F, Cador M, Caillé S, Stinus L, Le Moine C. Neural correlates of the motivational and somatic components of naloxone-precipitated morphine withdrawal. Eur J Neurosci. 2002;16:1377-89 pubmed
- Salles J, Sargueil F, Knoll Gellida A, Witters L, Cassagne C, Garbay B. Acetyl-CoA carboxylase and SREBP expression during peripheral nervous system myelination. Biochim Biophys Acta. 2003;1631:229-38 pubmed..Taken together, these results suggest that the coordinate expression of several lipogenic genes, which occurs during PNS myelination, could possibly be regulated by SREBP 2. ..
- Thoumine O, Lambert M, Mège R, Choquet D. Regulation of N-cadherin dynamics at neuronal contacts by ligand binding and cytoskeletal coupling. Mol Biol Cell. 2006;17:862-75 pubmed..Finally, spontaneous neuronal contacts enriched in N-cadherin exhibited similar turnover rates, suggesting that such dynamics of N-cadherin may represent an intrinsic mechanism underlying the plasticity of neuronal adhesions. ..
- Si Tayeb K, Monvoisin A, Mazzocco C, Lepreux S, Decossas M, Cubel G, et al. Matrix metalloproteinase 3 is present in the cell nucleus and is involved in apoptosis. Am J Pathol. 2006;169:1390-401 pubmed..This study elucidates for the first time the mechanisms of nuclear localization of a MMP and shows that nuclear MMP-3 can induce apoptosis via its catalytic activity. ..
- Dumartin B, Doudnikoff E, Gonon F, Bloch B. Differences in ultrastructural localization of dopaminergic D1 receptors between dorsal striatum and nucleus accumbens in the rat. Neurosci Lett. 2007;419:273-7 pubmed
- D Incau E, Couture C, Maureille B. Human tooth wear in the past and the present: tribological mechanisms, scoring systems, dental and skeletal compensations. Arch Oral Biol. 2012;57:214-29 pubmed publisher..Today's tribochemical pathological model has replaced the abrasive physiological model of the past. ..
- Touyarot K, Bonhomme D, Roux P, Alfos S, Lafenetre P, Richard E, et al. A mid-life vitamin A supplementation prevents age-related spatial memory deficits and hippocampal neurogenesis alterations through CRABP-I. PLoS ONE. 2013;8:e72101 pubmed publisher..Thus, vitamin A supplementation from middle-age could be a good strategy to maintain hippocampal plasticity and functions. ..
- ..We will discuss here the different conceptual and methodological advances that have led to a rethinking of the synapse as an organelle whose function is tightly linked to its dynamic organization. ..
- Barral Fraga L, Morin S, Rovira M, Urrea G, Magellan K, Guasch H. Short-term arsenic exposure reduces diatom cell size in biofilm communities. Environ Sci Pollut Res Int. 2016;23:4257-70 pubmed publisher..Our results have important implications for risk assessment, as the experimental As concentration used was lower than acute toxicity criteria established by the USEPA. ..
- Montespan C, Marvin S, Austin S, Burrage A, Roger B, Rayne F, et al. Multi-layered control of Galectin-8 mediated autophagy during adenovirus cell entry through a conserved PPxY motif in the viral capsid. PLoS Pathog. 2017;13:e1006217 pubmed publisher..2 resulting in reduced antigenic presentation. Our data thus demonstrate that a short PPxY-peptide motif in the adenoviral capsid permits multi-layered viral control of autophagic processes during entry. ..
- Konsman J, Parnet P, Dantzer R. Cytokine-induced sickness behaviour: mechanisms and implications. Trends Neurosci. 2002;25:154-9 pubmed..The cellular and molecular components of this previously unsuspected system are being progressively identified. These advances are opening new avenues for understanding brain disorders, including depression. ..
- Heine M, Groc L, Frischknecht R, Beique J, Lounis B, Rumbaugh G, et al. Surface mobility of postsynaptic AMPARs tunes synaptic transmission. Science. 2008;320:201-5 pubmed publisher..Physiological regulation of postsynaptic receptor mobility affects the fidelity of synaptic transmission by shaping the frequency dependence of synaptic responses. ..
- Monfoulet L, Rabier B, Chassande O, Fricain J. Drilled hole defects in mouse femur as models of intramembranous cortical and cancellous bone regeneration. Calcif Tissue Int. 2010;86:72-81 pubmed publisher..These models enable experimental genetics studies to investigate the cellular and molecular mechanisms of spontaneous cortical and cancellous bone repair and may be useful for pharmacological studies...
- Monfoulet L, Rabier B, Dacquin R, Anginot A, Photsavang J, Jurdic P, et al. Thyroid hormone receptor ? mediates thyroid hormone effects on bone remodeling and bone mass. J Bone Miner Res. 2011;26:2036-44 pubmed publisher..These data shed new light on the respective roles of TRs in the control of bone metabolism by TH...
- Kasanetz F, Lafourcade M, Deroche Gamonet V, Revest J, Berson N, Balado E, et al. Prefrontal synaptic markers of cocaine addiction-like behavior in rats. Mol Psychiatry. 2013;18:729-37 pubmed publisher..These data identify specific synaptic impairments in the pPFC associated with addiction and support the idea that alterations of synaptic plasticity are core markers of drug dependence. ..
- Tison F, Negre Pages L, Meissner W, Dupouy S, Li Q, Thiolat M, et al. Simvastatin decreases levodopa-induced dyskinesia in monkeys, but not in a randomized, placebo-controlled, multiple cross-over ("n-of-1") exploratory trial of simvastatin against levodopa-induced dyskinesia in Parkinson's disease patients. Parkinsonism Relat Disord. 2013;19:416-21 pubmed publisher..Simvastatin may improve levodopa-induced dyskinesia through striatal Ras-extracellular signal-regulated kinase pathway modulation...
- Arbogast T, Iacono G, Chevalier C, Afinowi N, Houbaert X, van Eede M, et al. Mouse models of 17q21.31 microdeletion and microduplication syndromes highlight the importance of Kansl1 for cognition. PLoS Genet. 2017;13:e1006886 pubmed publisher..31 deletion. Together, these novel mouse models provide new genetic tools valuable for the development of therapeutic approaches. ..
- Diguet E, Fernagut P, Normand E, Centelles L, Mulle C, Tison F. Experimental basis for the putative role of GluR6/kainate glutamate receptor subunit in Huntington's disease natural history. Neurobiol Dis. 2004;15:667-75 pubmed
- Bonfardin V, Theodosis D, Konnerth A, Oliet S. Kainate receptor-induced retrograde inhibition of glutamatergic transmission in vasopressin neurons. J Neurosci. 2012;32:1301-10 pubmed publisher..These findings suggest that activation of postsynaptic GluK1-containing KARs on VP neurons leads to the release of dynorphin, which in turn acts on presynaptic ?-opioid receptors to inhibit glutamate release. ..
- Zhang H, Etherington L, Hafner A, Belelli D, Coussen F, Delagrange P, et al. Regulation of AMPA receptor surface trafficking and synaptic plasticity by a cognitive enhancer and antidepressant molecule. Mol Psychiatry. 2013;18:471-84 pubmed publisher..Collectively, these data provide the first evidence that a therapeutically used drug targets the surface diffusion of AMPAR through a CaMKII-stargazin-PSD-95 pathway, to promote long-term synaptic plasticity. ..
- Taouji S, Higa A, Delom F, Palcy S, Mahon F, Pasquet J, et al. Phosphorylation of serine palmitoyltransferase long chain-1 (SPTLC1) on tyrosine 164 inhibits its activity and promotes cell survival. J Biol Chem. 2013;288:17190-201 pubmed publisher..Our observations provide a mechanistic explanation for imatinib-mediated cell death and a novel avenue for therapeutic strategies. ..
- Laye S, Gheusi G, Cremona S, Combe C, Kelley K, Dantzer R, et al. Endogenous brain IL-1 mediates LPS-induced anorexia and hypothalamic cytokine expression. Am J Physiol Regul Integr Comp Physiol. 2000;279:R93-8 pubmed..These findings indicate that endogenous brain IL-1 plays a pivotal role in the development of the hypothalamic cytokine response to a systemic inflammatory stimulus...
- Rome C, Roullot V, Couillaud F. Polymorphism of the untranslated regions of the F3/contactin mRNA in the rat nervous system. Brain Res Mol Brain Res. 2005;139:184-91 pubmed..The F3/contactin rat gene differs from the mouse gene for two reasons: (1) it contains two additional untranslated exons that are alternatively spliced and (2) it lacks the homologue mouse untranslated exon 0. ..
- Rakotoarisoa L, Carricaburu V, Leblanc C, Mironneau C, Mironneau J, Macrez N. Angiotensin II-induced delayed stimulation of phospholipase C gamma1 requires activation of both phosphatidylinositol 3-kinase gamma and tyrosine kinase in vascular myocytes. J Cell Mol Med. 2006;10:734-48 pubmed
- Hocquellet A, Odaert B, Cabanne C, Noubhani A, Dieryck W, Joucla G, et al. Structure-activity relationship of human liver-expressed antimicrobial peptide 2. Peptides. 2010;31:58-66 pubmed publisher..Altogether, these results show that the secondary structure of human LEAP-2 has a profound impact on its antibacterial activity. ..
- Strale P, Azioune A, Bugnicourt G, Lecomte Y, Chahid M, Studer V. Multiprotein Printing by Light-Induced Molecular Adsorption. Adv Mater. 2016;28:2024-9 pubmed publisher..LIMAP is used to perform selective immuno-assays, to dynamically control the adhesion of individual cells, and to achieve hierarchical co-cultures instrumental for tissue engineering. ..
- Bringaud F, Biteau N, Melville S, Hez S, El Sayed N, Leech V, et al. A new, expressed multigene family containing a hot spot for insertion of retroelements is associated with polymorphic subtelomeric regions of Trypanosoma brucei. Eukaryot Cell. 2002;1:137-51 pubmed..brucei strain TREU927/4 GUTat10.1. RHS genes comprise the remaining sequence of the size-polymorphic "repetitive region" described for T. brucei chromosome I, and a homologous gene family is present in the Trypanosoma cruzi genome...
- Mormede P, Andanson S, Auperin B, Beerda B, Guémené D, Malmkvist J, et al. Exploration of the hypothalamic-pituitary-adrenal function as a tool to evaluate animal welfare. Physiol Behav. 2007;92:317-39 pubmed..Usually, these results will be integrated with data from behavioral observation, production and pathology records in a comprehensive approach of farm animal welfare. ..
- Rivat C, Laboureyras E, Laulin J, Le Roy C, Richebe P, Simonnet G. Non-nociceptive environmental stress induces hyperalgesia, not analgesia, in pain and opioid-experienced rats. Neuropsychopharmacology. 2007;32:2217-28 pubmed..This latent pain sensitization model may be important for studying the transition from acute to chronic pain and individual differences in pain vulnerability associated with prior life events. ..
- Lenoir M, Ahmed S. Supply of a nondrug substitute reduces escalated heroin consumption. Neuropsychopharmacology. 2008;33:2272-82 pubmed..Escalated drug use may therefore persist, not so much because of a relative devaluation of nondrug substitutes, but because of a loss or reduction of their availability. ..
- Chaigne Delalande B, Moreau J, Legembre P. Rewinding the DISC. Arch Immunol Ther Exp (Warsz). 2008;56:9-14 pubmed publisher..However, the accurate molecular ordering upstream from the formation of DISC remains very puzzling and is highly debated. Herein we review some of the factors that would potentially facilitate or limit the formation of the DISC. ..
- Caruso M, Jenna S, Bouchecareilh M, Baillie D, Boismenu D, Halawani D, et al. GTPase-mediated regulation of the unfolded protein response in Caenorhabditis elegans is dependent on the AAA+ ATPase CDC-48. Mol Cell Biol. 2008;28:4261-74 pubmed publisher..In addition, we describe a novel signaling module involving CRP-1 and CDC-48 which may directly link the UPR to DNA remodeling and transcription control. ..
- Leen L, Filipe C, Billon A, Garmy Susini B, Jalvy S, Robbesyn F, et al. Estrogen-stimulated endothelial repair requires osteopontin. Arterioscler Thromb Vasc Biol. 2008;28:2131-6 pubmed publisher..We demonstrate here that E(2) acceleration of the endothelial repair requires osteopontin, both for bone marrow-derived cell recruitment and for endothelial cell migration and proliferation. ..
- Lafenetre P, Chaouloff F, Marsicano G. Bidirectional regulation of novelty-induced behavioral inhibition by the endocannabinoid system. Neuropharmacology. 2009;57:715-21 pubmed publisher..These data show a tightly regulated influence of the ECS on impulsive behaviors and suggest the involvement of endocannabinoid signaling in the pathophysiological modulation of ADHD and related disorders. ..
- Sauvanet C, Duvezin Caubet S, di Rago J, Rojo M. Energetic requirements and bioenergetic modulation of mitochondrial morphology and dynamics. Semin Cell Dev Biol. 2010;21:558-65 pubmed publisher..Finally, ex vivo studies (in mammals) and in vitro studies (in yeast) confirm the essential role of the inner membrane potential for mitochondrial fusion. ..
- Coustou V, Guegan F, Plazolles N, Baltz T. Complete in vitro life cycle of Trypanosoma congolense: development of genetic tools. PLoS Negl Trop Dis. 2010;4:e618 pubmed publisher..It represents a very useful tool to understand pathogenesis mechanisms and to study potential therapeutic targets either in vitro or in vivo using a mouse model. ..
- Varon C, Dubus P, Mazurier F, Asencio C, Chambonnier L, Ferrand J, et al. Helicobacter pylori infection recruits bone marrow-derived cells that participate in gastric preneoplasia in mice. Gastroenterology. 2012;142:281-91 pubmed publisher..Nearly 25% of dysplastic lesions include cells that originate from the BM. ..
- Levic S, Dulon D. The temporal characteristics of Ca2+ entry through L-type and T-type Ca2+ channels shape exocytosis efficiency in chick auditory hair cells during development. J Neurophysiol. 2012;108:3116-23 pubmed publisher..Overall, our results suggest that the temporal characteristics of Ca(2+) entry through T-type and L-type Ca(2+) channels greatly influence synaptic release by hair cells during cochlear development. ..
- Giannone G, Hosy E, Sibarita J, Choquet D, Cognet L. High-content super-resolution imaging of live cell by uPAINT. Methods Mol Biol. 2013;950:95-110 pubmed publisher..Interestingly, any membrane biomolecule that can be labeled with a fluorescent ligand can be studied, making uPAINT an extremely versatile method...
- Esteves A, Knoll Gellida A, Canclini L, Silvarrey M, AndrÃ© M, Babin P. Fatty acid binding proteins have the potential to channel dietary fatty acids into enterocyte nuclei. J Lipid Res. 2016;57:219-32 pubmed publisher..These data suggest that dietary FAs complexed with FABPs are able to reach the enterocyte nucleus with the potential to modulate nuclear activity. ..
- Barrier M, BÃ©gorre M, Baudrimont I, Dubois M, Freund Michel V, Marthan R, et al. Involvement of Heme Oxygenase-1 in particulate matter-induced impairment of NO-dependent relaxation in rat intralobar pulmonary arteries. Toxicol In Vitro. 2016;32:205-11 pubmed publisher..Therefore it highlights the role of HO-1 in particulate matter-induced detrimental effects in pulmonary circulation. ..
- Rigoulet M, Averet N, Mazat J, Guerin B, Cohadon F. Redistribution of the flux-control coefficients in mitochondrial oxidative phosphorylations in the course of brain edema. Biochim Biophys Acta. 1988;932:116-23 pubmed..5) was observed from the onset of intracellular edema for the threshold value of water/dry-weight tissue of 4.6. ..
- Hilmi S, Fournier M, Valeins H, Gandar J, Bonnet J. Myelin P0 glycoprotein: identification of the site phosphorylated in vitro and in vivo by endogenous protein kinases. J Neurochem. 1995;64:902-7 pubmed..Our results strongly suggest that the phosphorylation of these serine residues alters the secondary structure of this domain. Such a structural perturbation could play an important role in myelin compaction at the dense line level. ..
- Ciofi P. Phenotypical segregation among female rat hypothalamic gonadotropin-releasing hormone neurons as revealed by the sexually dimorphic coexpression of cholecystokinin and neurotensin. Neuroscience. 2000;99:133-47 pubmed..Thus, the gonad permanently organizes the gonadotropin-releasing hormone neuronal population, resulting, at least in females, in a mosaic of phenotypically distinct, functional subunits. ..
- Martin Negrier M, Charron G, Bloch B. Agonist stimulation provokes dendritic and axonal dopamine D(1) receptor redistribution in primary cultures of striatal neurons. Neuroscience. 2000;99:257-66 pubmed..This preparation will be useful to address various questions concerning the behavior and the trafficking of these receptors in neurons in relation to the neurotransmitter environment. ..
- Ito K, Rome C, Bouleau Y, Dulon D. Substance P mobilizes intracellular calcium and activates a nonselective cation conductance in rat spiral ganglion neurons. Eur J Neurosci. 2002;16:2095-102 pubmed..In SGNs, SP could have both a trophic action, via a calcium response, and a neuromodulatory role, by a depolarizing action through the activation of nonselective cation channels. ..
- Harizi H, Juzan M, Moreau J, Gualde N. Prostaglandins inhibit 5-lipoxygenase-activating protein expression and leukotriene B4 production from dendritic cells via an IL-10-dependent mechanism. J Immunol. 2003;170:139-46 pubmed..Taken together, our results suggest links between DC cyclooxygenase and 5-LO pathways during the inflammatory response, and FLAP is a key target for the PG-induced IL-10-suppressive effects. ..
- Porras G, De Deurwaerdère P, Moison D, Spampinato U. Conditional involvement of striatal serotonin3 receptors in the control of in vivo dopamine outflow in the rat striatum. Eur J Neurosci. 2003;17:771-81 pubmed
- Lenoir M, Serre F, Cantin L, Ahmed S. Intense sweetness surpasses cocaine reward. PLoS ONE. 2007;2:e698 pubmed