Experts and Doctors on rna interference in Strasbourg, Alsace Champagne Ardenne Lorraine, France


Locale: Strasbourg, Alsace Champagne Ardenne Lorraine, France
Topic: rna interference

Top Publications

  1. Dunoyer P, Himber C, Voinnet O. Induction, suppression and requirement of RNA silencing pathways in virulent Agrobacterium tumefaciens infections. Nat Genet. 2006;38:258-63 pubmed
    ..The similarities and specificities of the A. tumefaciens RNA silencing interaction are discussed and contrasted with the situation encountered with plant viruses. ..
  2. Zuber H, Scheer H, Ferrier E, Sement F, Mercier P, Stupfler B, et al. Uridylation and PABP Cooperate to Repair mRNA Deadenylated Ends in Arabidopsis. Cell Rep. 2016;14:2707-17 pubmed publisher
    ..Taken together, our results uncover a role for uridylation and PABP in repairing mRNA deadenylated ends and reveal that uridylation plays diverse roles in eukaryotic mRNA metabolism. ..
  3. Garcia D, Garcia S, Pontier D, Marchais A, Renou J, Lagrange T, et al. Ago hook and RNA helicase motifs underpin dual roles for SDE3 in antiviral defense and silencing of nonconserved intergenic regions. Mol Cell. 2012;48:109-20 pubmed publisher
    ..We identified endogenous SDE3 targets corresponding to nonconserved intergenic regions, transposons and recently evolved pseudogenes, unraveling striking functional convergences among plant and metazoan SDE3 pathways. ..
  4. Lupberger J, Zeisel M, Xiao F, Thumann C, Fofana I, Zona L, et al. EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy. Nat Med. 2011;17:589-95 pubmed publisher
    ..Inhibition of RTK function may constitute a new approach for prevention and treatment of HCV infection. ..
  5. Bai P, Canto C, Oudart H, Brunyánszki A, Cen Y, Thomas C, et al. PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation. Cell Metab. 2011;13:461-468 pubmed publisher
    ..These data show how PARP-1 inhibition has strong metabolic implications through the modulation of SIRT1 activity, a property that could be useful in the management not only of metabolic diseases, but also of cancer. ..
  6. Bai P, Canto C, Brunyánszki A, Huber A, Szántó M, Cen Y, et al. PARP-2 regulates SIRT1 expression and whole-body energy expenditure. Cell Metab. 2011;13:450-460 pubmed publisher
  7. Mueller S, Gausson V, Vodovar N, Deddouche S, Troxler L, Perot J, et al. RNAi-mediated immunity provides strong protection against the negative-strand RNA vesicular stomatitis virus in Drosophila. Proc Natl Acad Sci U S A. 2010;107:19390-5 pubmed publisher
    ..This result is of particular interest in view of the frequent transmission of medically relevant negative-strand RNA viruses to humans by insect vectors. ..
  8. Rejiba S, Bigand C, Parmentier C, Hajri A. Gemcitabine-based chemogene therapy for pancreatic cancer using Ad-dCK::UMK GDEPT and TS/RR siRNA strategies. Neoplasia. 2009;11:637-50 pubmed
    ..Together, these findings suggest that simultaneous TS/RRM2-gene silencing and dCK::UMK gene overexpression markedly improved gemcitabine's therapeutic activity. Clearly, this combined strategy warrants further investigation. ..
  9. Bortolamiol D, Pazhouhandeh M, Marrocco K, Genschik P, Ziegler Graff V. The Polerovirus F box protein P0 targets ARGONAUTE1 to suppress RNA silencing. Curr Biol. 2007;17:1615-21 pubmed
    ..Finally, we provide evidence that P0 physically interacts with AGO1. Based on these results, we propose that P0 hijacks the host SCF machinery to modulate gene silencing by destabilizing AGO1. ..

More Information


  1. Bischoff V, Vignal C, Duvic B, Boneca I, Hoffmann J, Royet J. Downregulation of the Drosophila immune response by peptidoglycan-recognition proteins SC1 and SC2. PLoS Pathog. 2006;2:e14 pubmed
    ..We further show that a strict control of IMD-pathway activation is essential to prevent bacteria-induced developmental defects and larval death. ..
  2. Huszar T, Imler J. Drosophila viruses and the study of antiviral host-defense. Adv Virus Res. 2008;72:227-65 pubmed publisher
    ..melanogaster model to study antiviral innate immunity and to better understand the complex interaction between arthropod-borne viruses and their insect vectors. ..
  3. Kemp C, Imler J. Antiviral immunity in drosophila. Curr Opin Immunol. 2009;21:3-9 pubmed publisher
    ..In particular, DExD/H box helicases appear to play a crucial role in the cytosolic detection of viral RNAs in flies and mammals...
  4. Momboisse F, Lonchamp E, Calco V, Ceridono M, Vitale N, Bader M, et al. betaPIX-activated Rac1 stimulates the activation of phospholipase D, which is associated with exocytosis in neuroendocrine cells. J Cell Sci. 2009;122:798-806 pubmed publisher
  5. Kozlowska Makulska A, Guilley H, Szyndel M, Beuve M, Lemaire O, Herrbach E, et al. P0 proteins of European beet-infecting poleroviruses display variable RNA silencing suppression activity. J Gen Virol. 2010;91:1082-91 pubmed publisher
    ..These results are the first reported evidence that P0 proteins of two closely related beet poleroviruses show strain-specific differences in their effects on RNA silencing. ..
  6. Selimovic D, Sprenger A, Hannig M, Haikel Y, Hassan M. Apoptosis related protein-1 triggers melanoma cell death via interaction with the juxtamembrane region of p75 neurotrophin receptor. J Cell Mol Med. 2012;16:349-61 pubmed publisher
    ..Thus, besides the analysis of its pro-apoptotic function, our data provide insight into the molecular mechanism of APR-1-induced apoptosis of melanoma cells. ..
  7. Jacques A, Ghannam A, Erhardt M, De Ruffray P, Baillieul F, Kauffmann S. NtLRP1, a tobacco leucine-rich repeat gene with a possible role as a modulator of the hypersensitive response. Mol Plant Microbe Interact. 2006;19:747-57 pubmed publisher
    ..The results suggest that NtLRP1 acts as a modulator of the HR and that retention in the ER is essential for its function...
  8. Marrocco K, Criqui M, Zervudacki J, Schott G, Eisler H, Parnet A, et al. APC/C-mediated degradation of dsRNA-binding protein 4 (DRB4) involved in RNA silencing. PLoS ONE. 2012;7:e35173 pubmed publisher
  9. Meyer M, Déliot N, Chasserot Golaz S, Premont R, Bader M, Vitale N. Regulation of neuroendocrine exocytosis by the ARF6 GTPase-activating protein GIT1. J Biol Chem. 2006;281:7919-26 pubmed
    ..We propose that GIT1 represents part of the pathway that inactivates ARF6-dependent reactions and thereby negatively regulates and/or terminates exocytotic release. ..
  10. Chiba S, Hleibieh K, Delbianco A, Klein E, Ratti C, Ziegler Graff V, et al. The benyvirus RNA silencing suppressor is essential for long-distance movement, requires both zinc-finger and NoLS basic residues but not a nucleolar localization for its silencing-suppression activity. Mol Plant Microbe Interact. 2013;26:168-81 pubmed publisher
    ..Conversely, RNA silencing suppression appeared independent of the nucleolar localization of the protein, and a correlation between BNYVV VSR expression and long-distance movement was established. ..
  11. Hoffmann L, Besseau S, Geoffroy P, Ritzenthaler C, Meyer D, Lapierre C, et al. Silencing of hydroxycinnamoyl-coenzyme A shikimate/quinate hydroxycinnamoyltransferase affects phenylpropanoid biosynthesis. Plant Cell. 2004;16:1446-65 pubmed
    ..These results demonstrate the function of the acyltransferase in phenylpropanoid biosynthesis. ..
  12. Haas G, Azevedo J, Moissiard G, Geldreich A, Himber C, Bureau M, et al. Nuclear import of CaMV P6 is required for infection and suppression of the RNA silencing factor DRB4. EMBO J. 2008;27:2102-12 pubmed publisher
    ..This study identifies both genetic and physical interactions between a VSR to a host RNA silencing component, and highlights the importance of subcellular compartmentalization in VSR function...
  13. Agouni A, Sourbier C, Danilin S, Rothhut S, Lindner V, Jacqmin D, et al. Parathyroid hormone-related protein induces cell survival in human renal cell carcinoma through the PI3K Akt pathway: evidence for a critical role for integrin-linked kinase and nuclear factor kappa B. Carcinogenesis. 2007;28:1893-901 pubmed
    ..Since RCC remains refractory to current therapies, our results establish that the PI3K/ILK/Akt/NF-kappaB axis is a promising target for therapeutic intervention. ..
  14. Besseau S, Hoffmann L, Geoffroy P, Lapierre C, Pollet B, Legrand M. Flavonoid accumulation in Arabidopsis repressed in lignin synthesis affects auxin transport and plant growth. Plant Cell. 2007;19:148-62 pubmed
    ..These data demonstrate that the reduced size phenotype of HCT-silenced plants is not due to the alteration of lignin synthesis but to flavonoid accumulation. ..