Experts and Doctors on colonic neoplasms in Helsinki, Uusimaa, Finland
Locale: Helsinki, Uusimaa, Finland
Topic: colonic neoplasms
Hoglund P, Haila S, Socha J, Tomaszewski L, Saarialho Kere U, Karjalainen Lindsberg M, et al
. Mutations of the Down-regulated in adenoma (DRA) gene cause congenital chloride diarrhoea. Nat Genet. 1996;14:316-9 pubmed
..We conclude that DRA is an intestinal anion transport molecule that causes chloride diarrhoea when mutated. ..
Bister V, Salmela M, Karjalainen Lindsberg M, Uria J, Lohi J, Puolakkainen P, et al
. Differential expression of three matrix metalloproteinases, MMP-19, MMP-26, and MMP-28, in normal and inflamed intestine and colon cancer. Dig Dis Sci. 2004;49:653-61 pubmed
..In contrast to many previously characterized MMPs, MMP-19 and MMP-28 are downregulated during malignant transformation of the colon and may play a prominent role in tissue homeostasis. ..
Abdel Rahman W, Knuutila S, Peltomaki P, Harrison D, Bader S. Truncation of MBD4 predisposes to reciprocal chromosomal translocations and alters the response to therapeutic agents in colon cancer cells. DNA Repair (Amst). 2008;7:321-8 pubmed
..We also show that over-expression of MBD4(tru) in DLD1 alters the colony survival after exposure to cisplatin or etoposide. These data suggest a wide role for MBD4 in DNA damage response and maintaining chromosomal stability. ..
Haveri H, Westerholm Ormio M, Lindfors K, Maki M, Savilahti E, Andersson L, et al
. Transcription factors GATA-4 and GATA-6 in normal and neoplastic human gastrointestinal mucosa. BMC Gastroenterol. 2008;8:9 pubmed publisher
..Furthermore, GATA-4, GATA-6 and Ihh expression is altered in premalignant dysplastic lesions and reduced in overt cancer. ..
Ylösmäki E, Lavilla Alonso S, Jäämaa S, Vaha Koskela M, af Hällström T, Hemminki A, et al
. MicroRNA-mediated suppression of oncolytic adenovirus replication in human liver. PLoS ONE. 2013;8:e54506 pubmed publisher
Petrova T, Nykänen A, Norrmen C, Ivanov K, Andersson L, Haglund C, et al
. Transcription factor PROX1 induces colon cancer progression by promoting the transition from benign to highly dysplastic phenotype. Cancer Cell. 2008;13:407-19 pubmed publisher
..Our data underscore the complexity of cancer pathogenesis and implicate PROX1 in malignant tumor progression through the regulation of cell polarity and adhesion. ..