Experts and Doctors on zinc in Israel


Locale: Israel
Topic: zinc

Top Publications

  1. Sela Passwell N, Kikkeri R, Dym O, Rozenberg H, Margalit R, Arad Yellin R, et al. Antibodies targeting the catalytic zinc complex of activated matrix metalloproteinases show therapeutic potential. Nat Med. 2011;18:143-7 pubmed publisher
    ..Here we propose a general experimental strategy for generating inhibitory antibodies that effectively target the in vivo activity of dysregulated metalloproteinases by mimicking the mechanism employed by TIMPs. ..
  2. Nitzan Y, Sekler I, Silverman W. Histochemical and histofluorescence tracing of chelatable zinc in the developing mouse. J Histochem Cytochem. 2004;52:529-39 pubmed
    ..g., in liver and blood. The ubiquity of zinc in the embryo, particularly in rapidly proliferating tissues, suggests a widespread role in fetal physiology. ..
  3. Kleifeld O, Kotra L, Gervasi D, Brown S, Bernardo M, Fridman R, et al. X-ray absorption studies of human matrix metalloproteinase-2 (MMP-2) bound to a highly selective mechanism-based inhibitor. comparison with the latent and active forms of the enzyme. J Biol Chem. 2001;276:17125-31 pubmed
    ..Interestingly, the novel mode of binding of the inhibitor to the catalytic zinc reconstructs the conformational environment around the active site metal ion back to that of the proenzyme. ..
  4. Margalit O, Simon A, Yakubov E, Puca R, Yosepovich A, Avivi C, et al. Zinc supplementation augments in vivo antitumor effect of chemotherapy by restoring p53 function. Int J Cancer. 2012;131:E562-8 pubmed publisher
    ..In addition, HIPK2 may serve as a new biomarker for tumor aggressiveness. ..
  5. Barkalifa R, Hershfinkel M, Friedman J, Kozak A, Sekler I. The lipophilic zinc chelator DP-b99 prevents zinc induced neuronal death. Eur J Pharmacol. 2009;618:15-21 pubmed publisher
    ..Our results indicate that DP-b99 is effective in attenuating Zn(2+) and Ca(2+) surges and protecting neurons against a toxic Zn(2+)-rise. This may underlie the efficacy of DP-b99 in stroke treatment. ..
  6. Rosenblum G, Meroueh S, Toth M, Fisher J, Fridman R, Mobashery S, et al. Molecular structures and dynamics of the stepwise activation mechanism of a matrix metalloproteinase zymogen: challenging the cysteine switch dogma. J Am Chem Soc. 2007;129:13566-74 pubmed
    ..Here we demonstrate the synergism among long-range protein conformational transitions, local structural rearrangements, and fine atomic events in the process of zymogen activation. ..
  7. Priel T, Hershfinkel M. Zinc influx and physiological consequences in the beta-insulinoma cell line, Min6. Biochem Biophys Res Commun. 2006;346:205-12 pubmed
    ..Our results demonstrate homeostatic crosstalk between the plasma membrane and intracellular zinc transporters and suggest that attenuating zinc influx may enhance beta-cell survival. ..
  8. Cohen N, Golik A. Zinc balance and medications commonly used in the management of heart failure. Heart Fail Rev. 2006;11:19-24 pubmed
    ..It was shown that ACE inhibitors may inhibit the activity of different MMPs. The exact interrelationship between HF, zinc-containing enzymes, zinc deficiency and the clinical manifestation of HF has to be investigated. ..
  9. Sheffer M, Simon A, Jacob Hirsch J, Rechavi G, Domany E, Givol D, et al. Genome-wide analysis discloses reversal of the hypoxia-induced changes of gene expression in colon cancer cells by zinc supplementation. Oncotarget. 2011;2:1191-202 pubmed
    ..We conclude that the hypoxia pathway is a potential therapeutic target addressed by zinc that also influences tumor cell response to anticancer drug. ..

More Information


  1. Ohana E, Hoch E, Keasar C, Kambe T, Yifrach O, Hershfinkel M, et al. Identification of the Zn2+ binding site and mode of operation of a mammalian Zn2+ transporter. J Biol Chem. 2009;284:17677-86 pubmed publisher
    ..These findings indicate, for the first time, that Zn2+ transport mediated by a mammalian ZnT is catalyzed by H+/Zn2+ exchange and identify the zinc binding site of ZnT proteins essential for zinc transport. ..
  2. Morad Y, Banin E, Averbukh E, Berenshtein E, Obolensky A, Chevion M. Treatment of ocular tissues exposed to nitrogen mustard: beneficial effect of zinc desferrioxamine combined with steroids. Invest Ophthalmol Vis Sci. 2005;46:1640-6 pubmed
  3. Levy S, Kafri M, Carmi M, Barkai N. The competitive advantage of a dual-transporter system. Science. 2011;334:1408-12 pubmed publisher
    ..Dual-transporter systems appear to prolong preparation for starvation and to facilitate subsequent recovery, which may optimize sensing of nutrient depletion by integrating internal and external information about nutrient availability. ..
  4. Elgazar V, Razanov V, Stoltenberg M, Hershfinkel M, Huleihel M, Nitzan Y, et al. Zinc-regulating proteins, ZnT-1, and metallothionein I/II are present in different cell populations in the mouse testis. J Histochem Cytochem. 2005;53:905-12 pubmed
    ..The specific expression of ZnT-1 in the Sertoli cells, moreover, is consistent with their role in maintaining a nurturing, closely regulated environment for spermatogenesis. ..
  5. Besser L, Chorin E, Sekler I, Silverman W, Atkin S, Russell J, et al. Synaptically released zinc triggers metabotropic signaling via a zinc-sensing receptor in the hippocampus. J Neurosci. 2009;29:2890-901 pubmed publisher
    ..Our results describe a unique role for synaptic Zn(2+) acting as the physiological ligand of a metabotropic receptor and provide a novel pathway by which synaptic Zn(2+) can regulate neuronal function. ..
  6. Ohana E, Segal D, Palty R, Ton That D, Moran A, Sensi S, et al. A sodium zinc exchange mechanism is mediating extrusion of zinc in mammalian cells. J Biol Chem. 2004;279:4278-84 pubmed
    ..Such mechanism is likely to play an important role, not only in generating the transmembrane zinc gradients, but also in protecting cells from the potentially toxic effects of permeation of this ion. ..
  7. Cohen L, Asraf H, Sekler I, Hershfinkel M. Extracellular pH regulates zinc signaling via an Asp residue of the zinc-sensing receptor (ZnR/GPR39). J Biol Chem. 2012;287:33339-50 pubmed
    ..In conclusion, ZnR/GPR39 is tuned to sense physiologically relevant changes in extracellular pH that thus regulate ZnR-dependent signaling and ion transport activity. ..
  8. Solomon H, Buganim Y, Kogan Sakin I, Pomeraniec L, Assia Y, Madar S, et al. Various p53 mutant proteins differently regulate the Ras circuit to induce a cancer-related gene signature. J Cell Sci. 2012;125:3144-52 pubmed publisher
    ..Our findings were further corroborated in human tumor-derived cell lines expressing Ras and the aforementioned mutated p53 proteins. These data might assist in future tailor-made therapy targeting the mutant p53-Ras axis in cancer. ..
  9. Hoch E, Lin W, Chai J, Hershfinkel M, Fu D, Sekler I. Histidine pairing at the metal transport site of mammalian ZnT transporters controls Zn2+ over Cd2+ selectivity. Proc Natl Acad Sci U S A. 2012;109:7202-7 pubmed publisher
  10. Sharir H, Zinger A, Nevo A, Sekler I, Hershfinkel M. Zinc released from injured cells is acting via the Zn2+-sensing receptor, ZnR, to trigger signaling leading to epithelial repair. J Biol Chem. 2010;285:26097-106 pubmed publisher
    ..Thus our results indicate that extracellular Zn(2+), which is either applied or released following injury, activates ZnR/GPR39 to promote signaling leading to epithelial repair. ..
  11. Karol N, Brodski C, Bibi Y, Kaisman T, Forberg M, Hershfinkel M, et al. Zinc homeostatic proteins in the CNS are regulated by crosstalk between extracellular and intracellular zinc. J Cell Physiol. 2010;224:567-74 pubmed publisher
    ..Our findings support the conclusion that ZHP expression is regulated by crosstalk between synaptic and intracellular pools of Zn(2+). ..
  12. Kessler E, Safrin M, Abrams W, Rosenbloom J, Ohman D. Inhibitors and specificity of Pseudomonas aeruginosa LasA. J Biol Chem. 1997;272:9884-9 pubmed
    ..Substrates that contain no Gly-Gly peptide bonds such as beta-casein appear to be resistant to LasA. ..
  13. Asraf H, Salomon S, Nevo A, Sekler I, Mayer D, Hershfinkel M. The ZnR/GPR39 interacts with the CaSR to enhance signaling in prostate and salivary epithelia. J Cell Physiol. 2014;229:868-77 pubmed publisher
    ..Importantly, Zn(2+) -dependent activation of ZnR/GPR39 also enhances the expression of the Ca(2+) -binding protein S100A4 that is linked to invasion of prostate cancer cells. ..
  14. Perez Y, Shorer Z, Liani Leibson K, Chabosseau P, Kadir R, Volodarsky M, et al. SLC30A9 mutation affecting intracellular zinc homeostasis causes a novel cerebro-renal syndrome. Brain. 2017;140:928-939 pubmed publisher
  15. Cohen L, Azriel Tamir H, Arotsker N, Sekler I, Hershfinkel M. Zinc sensing receptor signaling, mediated by GPR39, reduces butyrate-induced cell death in HT29 colonocytes via upregulation of clusterin. PLoS ONE. 2012;7:e35482 pubmed publisher
    ..Moreover, we identify GPR39 as the molecular moiety of ZnR in HT29 and native colonocytes. ..
  16. Hershfinkel M, Kandler K, Knoch M, Dagan Rabin M, Aras M, Abramovitch Dahan C, et al. Intracellular zinc inhibits KCC2 transporter activity. Nat Neurosci. 2009;12:725-7 pubmed publisher
    ..The link between Zn(2+) and KCC2 activity provides a previously unknown target for neuroprotection and may be important in activity-dependent regulation of inhibitory synaptic transmission. ..
  17. Avraham N, Soifer I, Carmi M, Barkai N. Increasing population growth by asymmetric segregation of a limiting resource during cell division. Mol Syst Biol. 2013;9:656 pubmed publisher
    ..Our data suggest a new stress-response strategy, in which the dilution of a limiting cellular resource is prevented by maintaining it within a subset of dividing cells, thereby increasing population growth. ..
  18. Beharier O, Dror S, Levy S, Kahn J, Mor M, Etzion S, et al. ZnT-1 protects HL-1 cells from simulated ischemia-reperfusion through activation of Ras-ERK signaling. J Mol Med (Berl). 2012;90:127-38 pubmed publisher
    ..However, following reperfusion ZnT-1 levels were found to be decreased. Our findings indicate that ZnT-1 may have important role in the ischemic myocardium through its ability to interact with Raf-1 kinase. ..
  19. Kaisman Elbaz T, Sekler I, Fishman D, Karol N, Forberg M, Kahn N, et al. Cell death induced by zinc and cadmium is mediated by clusterin in cultured mouse seminiferous tubules. J Cell Physiol. 2009;220:222-9 pubmed publisher
    ..Taken together, our results indicate that Zn(2+) and Cd(2+) influx induce expression and secretion of clusterin, thereby linking metal homeostasis and germ cell fate...
  20. Tako E, Ferket P, Uni Z. Changes in chicken intestinal zinc exporter mRNA expression and small intestinal functionality following intra-amniotic zinc-methionine administration. J Nutr Biochem. 2005;16:339-46 pubmed
    ..These results suggest that ZnMet administration into prenatal intestine via injection into the amniotic fluid enhances intestinal development and improves its functionality. ..
  21. Bar A, Razaphkovsky V, Shinder D, Vax E. Alternative procedures for molt induction: practical aspects. Poult Sci. 2003;82:543-50 pubmed
    ..Zn feeding increased the yolk Zn content slightly in eggs laid during the induction period and at the onset of production. In trial 2, only Zn-CaP markedly increased yolk Zn of eggs laid during the first 5 d of production...
  22. Hershkovitz E, Printzman L, Segev Y, Levy J, Phillip M. Zinc supplementation increases the level of serum insulin-like growth factor-I but does not promote growth in infants with nonorganic failure to thrive. Horm Res. 1999;52:200-4 pubmed
    ..88-21.31). No change was demonstrated in serum IGFBP-3 levels in either study group. We conclude that although zinc supplementation increased serum IGF-I levels, it did not improve the growth parameters of infants with NOFTT...