Genomes and Genes
Experts and Doctors on zinc in Israel
- Ohana E, Hoch E, Keasar C, Kambe T, Yifrach O, Hershfinkel M, et al. Identification of the Zn2+ binding site and mode of operation of a mammalian Zn2+ transporter. J Biol Chem. 2009;284:17677-86 pubmed publisher..These findings indicate, for the first time, that Zn2+ transport mediated by a mammalian ZnT is catalyzed by H+/Zn2+ exchange and identify the zinc binding site of ZnT proteins essential for zinc transport. ..
- Morad Y, Banin E, Averbukh E, Berenshtein E, Obolensky A, Chevion M. Treatment of ocular tissues exposed to nitrogen mustard: beneficial effect of zinc desferrioxamine combined with steroids. Invest Ophthalmol Vis Sci. 2005;46:1640-6 pubmed
- Levy S, Kafri M, Carmi M, Barkai N. The competitive advantage of a dual-transporter system. Science. 2011;334:1408-12 pubmed publisher..Dual-transporter systems appear to prolong preparation for starvation and to facilitate subsequent recovery, which may optimize sensing of nutrient depletion by integrating internal and external information about nutrient availability. ..
- Elgazar V, Razanov V, Stoltenberg M, Hershfinkel M, Huleihel M, Nitzan Y, et al. Zinc-regulating proteins, ZnT-1, and metallothionein I/II are present in different cell populations in the mouse testis. J Histochem Cytochem. 2005;53:905-12 pubmed..The specific expression of ZnT-1 in the Sertoli cells, moreover, is consistent with their role in maintaining a nurturing, closely regulated environment for spermatogenesis. ..
- Besser L, Chorin E, Sekler I, Silverman W, Atkin S, Russell J, et al. Synaptically released zinc triggers metabotropic signaling via a zinc-sensing receptor in the hippocampus. J Neurosci. 2009;29:2890-901 pubmed publisher..Our results describe a unique role for synaptic Zn(2+) acting as the physiological ligand of a metabotropic receptor and provide a novel pathway by which synaptic Zn(2+) can regulate neuronal function. ..
- Ohana E, Segal D, Palty R, Ton That D, Moran A, Sensi S, et al. A sodium zinc exchange mechanism is mediating extrusion of zinc in mammalian cells. J Biol Chem. 2004;279:4278-84 pubmed..Such mechanism is likely to play an important role, not only in generating the transmembrane zinc gradients, but also in protecting cells from the potentially toxic effects of permeation of this ion. ..
- Cohen L, Asraf H, Sekler I, Hershfinkel M. Extracellular pH regulates zinc signaling via an Asp residue of the zinc-sensing receptor (ZnR/GPR39). J Biol Chem. 2012;287:33339-50 pubmed..In conclusion, ZnR/GPR39 is tuned to sense physiologically relevant changes in extracellular pH that thus regulate ZnR-dependent signaling and ion transport activity. ..
- Solomon H, Buganim Y, Kogan Sakin I, Pomeraniec L, Assia Y, Madar S, et al. Various p53 mutant proteins differently regulate the Ras circuit to induce a cancer-related gene signature. J Cell Sci. 2012;125:3144-52 pubmed publisher..Our findings were further corroborated in human tumor-derived cell lines expressing Ras and the aforementioned mutated p53 proteins. These data might assist in future tailor-made therapy targeting the mutant p53-Ras axis in cancer. ..
- Sharir H, Zinger A, Nevo A, Sekler I, Hershfinkel M. Zinc released from injured cells is acting via the Zn2+-sensing receptor, ZnR, to trigger signaling leading to epithelial repair. J Biol Chem. 2010;285:26097-106 pubmed publisher..Thus our results indicate that extracellular Zn(2+), which is either applied or released following injury, activates ZnR/GPR39 to promote signaling leading to epithelial repair. ..
- Karol N, Brodski C, Bibi Y, Kaisman T, Forberg M, Hershfinkel M, et al. Zinc homeostatic proteins in the CNS are regulated by crosstalk between extracellular and intracellular zinc. J Cell Physiol. 2010;224:567-74 pubmed publisher..Our findings support the conclusion that ZHP expression is regulated by crosstalk between synaptic and intracellular pools of Zn(2+). ..
- Kessler E, Safrin M, Abrams W, Rosenbloom J, Ohman D. Inhibitors and specificity of Pseudomonas aeruginosa LasA. J Biol Chem. 1997;272:9884-9 pubmed..Substrates that contain no Gly-Gly peptide bonds such as beta-casein appear to be resistant to LasA. ..
- Asraf H, Salomon S, Nevo A, Sekler I, Mayer D, Hershfinkel M. The ZnR/GPR39 interacts with the CaSR to enhance signaling in prostate and salivary epithelia. J Cell Physiol. 2014;229:868-77 pubmed publisher..Importantly, Zn(2+) -dependent activation of ZnR/GPR39 also enhances the expression of the Ca(2+) -binding protein S100A4 that is linked to invasion of prostate cancer cells. ..
- Cohen L, Azriel Tamir H, Arotsker N, Sekler I, Hershfinkel M. Zinc sensing receptor signaling, mediated by GPR39, reduces butyrate-induced cell death in HT29 colonocytes via upregulation of clusterin. PLoS ONE. 2012;7:e35482 pubmed publisher..Moreover, we identify GPR39 as the molecular moiety of ZnR in HT29 and native colonocytes. ..
- Hershfinkel M, Kandler K, Knoch M, Dagan Rabin M, Aras M, Abramovitch Dahan C, et al. Intracellular zinc inhibits KCC2 transporter activity. Nat Neurosci. 2009;12:725-7 pubmed publisher..The link between Zn(2+) and KCC2 activity provides a previously unknown target for neuroprotection and may be important in activity-dependent regulation of inhibitory synaptic transmission. ..
- Avraham N, Soifer I, Carmi M, Barkai N. Increasing population growth by asymmetric segregation of a limiting resource during cell division. Mol Syst Biol. 2013;9:656 pubmed publisher..Our data suggest a new stress-response strategy, in which the dilution of a limiting cellular resource is prevented by maintaining it within a subset of dividing cells, thereby increasing population growth. ..
- Beharier O, Dror S, Levy S, Kahn J, Mor M, Etzion S, et al. ZnT-1 protects HL-1 cells from simulated ischemia-reperfusion through activation of Ras-ERK signaling. J Mol Med (Berl). 2012;90:127-38 pubmed publisher..However, following reperfusion ZnT-1 levels were found to be decreased. Our findings indicate that ZnT-1 may have important role in the ischemic myocardium through its ability to interact with Raf-1 kinase. ..
- Kaisman Elbaz T, Sekler I, Fishman D, Karol N, Forberg M, Kahn N, et al. Cell death induced by zinc and cadmium is mediated by clusterin in cultured mouse seminiferous tubules. J Cell Physiol. 2009;220:222-9 pubmed publisher..Taken together, our results indicate that Zn(2+) and Cd(2+) influx induce expression and secretion of clusterin, thereby linking metal homeostasis and germ cell fate...
- Tako E, Ferket P, Uni Z. Changes in chicken intestinal zinc exporter mRNA expression and small intestinal functionality following intra-amniotic zinc-methionine administration. J Nutr Biochem. 2005;16:339-46 pubmed..These results suggest that ZnMet administration into prenatal intestine via injection into the amniotic fluid enhances intestinal development and improves its functionality. ..
- Bar A, Razaphkovsky V, Shinder D, Vax E. Alternative procedures for molt induction: practical aspects. Poult Sci. 2003;82:543-50 pubmed..Zn feeding increased the yolk Zn content slightly in eggs laid during the induction period and at the onset of production. In trial 2, only Zn-CaP markedly increased yolk Zn of eggs laid during the first 5 d of production...
- Hershkovitz E, Printzman L, Segev Y, Levy J, Phillip M. Zinc supplementation increases the level of serum insulin-like growth factor-I but does not promote growth in infants with nonorganic failure to thrive. Horm Res. 1999;52:200-4 pubmed..88-21.31). No change was demonstrated in serum IGFBP-3 levels in either study group. We conclude that although zinc supplementation increased serum IGF-I levels, it did not improve the growth parameters of infants with NOFTT...