Experts and Doctors on vulva in United States


Locale: United States
Topic: vulva

Top Publications

  1. Inoue T, Wang M, Ririe T, Fernandes J, Sternberg P. Transcriptional network underlying Caenorhabditis elegans vulval development. Proc Natl Acad Sci U S A. 2005;102:4972-7 pubmed
  2. Sternberg P, Felix M. Evolution of cell lineage. Curr Opin Genet Dev. 1997;7:543-50 pubmed
    ..Stochastic specification of cell fate may evolve to a fixed cell lineage and specification by cell interactions to autonomous specification. Comparative developmental studies also shed light on the evolution of asymmetry. ..
  3. Lenschow C, Copley S, Gardiner J, Talbot Z, Vitenzon A, Brecht M. Sexually Monomorphic Maps and Dimorphic Responses in Rat Genital Cortex. Curr Biol. 2016;26:106-13 pubmed publisher
    ..Genital maps indicate a deep homology of penis and clitoris representations in line with a fundamentally bi-sexual layout [16] of the vertebrate brain. ..
  4. Brown C, Bachmann G, Wan J, Foster D. Pain Rating in Women with Provoked Vestibulodynia: Evaluating Influence of Race. J Womens Health (Larchmt). 2016;25:57-62 pubmed publisher
    ..06 units). Race had no effect on pain after adjusting for other variables. While race was associated with functional impairment, after accounting for this, race was not associated with level of vulvar pain with PVD. ..
  5. Goetsch M. Incidence of Bartholin's duct occlusion after superficial localized vestibulectomy. Am J Obstet Gynecol. 2009;200:688.e1-6 pubmed publisher
    ..The objective of the study was to analyze the incidence of occlusion of Bartholin's ducts after the procedure of superficial localized vestibulectomy for severe vulvar vestibulitis...
  6. Prause N, Cerny J, Janssen E. The labial photoplethysmograph: a new instrument for assessing genital hemodynamic changes in women. J Sex Med. 2005;2:58-65 pubmed
    ..The LP, while somewhat more difficult to place and less comfortable than the VP, is a promising new measure of genital response in women that warrants further development. ..
  7. Thompson B, Lamont L, Kimble J. Germ-line induction of the Caenorhabditis elegans vulva. Proc Natl Acad Sci U S A. 2006;103:620-5 pubmed
    ..Our findings reveal new insights into germ line-to-soma signals and the role of PUF proteins in animal development. ..
  8. Ambros V. Cell cycle-dependent sequencing of cell fate decisions in Caenorhabditis elegans vulva precursor cells. Development. 1999;126:1947-56 pubmed
    ..Coupling developmental decisions to cell cycle transitions may provide a mechanism for prioritizing or ordering choices of cell fates for multipotential cells...
  9. Barr M, Sternberg P. A polycystic kidney-disease gene homologue required for male mating behaviour in C. elegans. Nature. 1999;401:386-9 pubmed
    ..PKD-2, the C. elegans homologue of PKD2, is localized to the same neurons as LOV-1, suggesting that they function in the same pathway...

More Information


  1. Green J, Inoue T, Sternberg P. The C. elegans ROR receptor tyrosine kinase, CAM-1, non-autonomously inhibits the Wnt pathway. Development. 2007;134:4053-62 pubmed
    ..A sequestration model is supported by our findings that the CAM-1 ECD binds to several Wnts in vitro. These results demonstrate how ROR proteins help to refine the spatial pattern of Wnt activity in a complex multicellular environment...
  2. Hobson R, Hapiak V, Xiao H, Buehrer K, Komuniecki P, Komuniecki R. SER-7, a Caenorhabditis elegans 5-HT7-like receptor, is essential for the 5-HT stimulation of pharyngeal pumping and egg laying. Genetics. 2006;172:159-69 pubmed
    ..Taken together, these results suggest that SER-7 is essential for the 5-HT stimulation of both egg laying and pharyngeal pumping, but that other signaling pathways can probably fulfill similar roles in vivo. ..
  3. Inoue T, Sherwood D, Aspöck G, Butler J, Gupta B, Kirouac M, et al. Gene expression markers for Caenorhabditis elegans vulval cells. Gene Expr Patterns. 2002;2:235-41 pubmed
    ..Together, expressions of markers distinguish six cell types, and reveal a strict temporal control of gene expression in the developing vulva. ..
  4. Sherwood D, Butler J, Kramer J, Sternberg P. FOS-1 promotes basement-membrane removal during anchor-cell invasion in C. elegans. Cell. 2005;121:951-62 pubmed
    ..These results reveal a key genetic network that controls basement-membrane removal during cell invasion. ..
  5. Margesson L. Vulvovaginal dryness and itching. Skin Therapy Lett. 2001;6:3-4 pubmed
    ..Dermatologists should be able to sort out the causes of the itching and irritation, and understand the approaches to therapy...
  6. Mohler W, Shemer G, del Campo J, Valansi C, Opoku Serebuoh E, Scranton V, et al. The type I membrane protein EFF-1 is essential for developmental cell fusion. Dev Cell. 2002;2:355-62 pubmed
    ..Thus, EFF-1 is a key component in the mechanism of cell fusion, a process essential to normal animal development. ..
  7. Johnson R, Liu L, Hanna Rose W, Chamberlin H. The Caenorhabditis elegans heterochronic gene lin-14 coordinates temporal progression and maturation in the egg-laying system. Dev Dyn. 2009;238:394-404 pubmed publisher
    ..Together, these experiments outline a function for LIN-14 in coordinating the temporal progression of development, which is separable from its role in regulating stage-specific events during C. elegans postembryonic development. ..
  8. Rufforny I, Wilkinson E, Liu C, Zhu H, Buteral M, Massoll N. Human papillomavirus infection and p16(INK4a) protein expression in vulvar intraepithelial neoplasia and invasive squamous cell carcinoma. J Low Genit Tract Dis. 2005;9:108-13 pubmed
    ..Expression of p16(INK4a) may aid in the diagnosis of HPV-related lesions and as such may be of value as a surrogate marker in the diagnosis of vulvar premalignant and malignant lesions. ..
  9. Giurumescu C, Sternberg P, Asthagiri A. Predicting phenotypic diversity and the underlying quantitative molecular transitions. PLoS Comput Biol. 2009;5:e1000354 pubmed publisher
  10. Portman D, Bachmann G, Simon J. Ospemifene, a novel selective estrogen receptor modulator for treating dyspareunia associated with postmenopausal vulvar and vaginal atrophy. Menopause. 2013;20:623-30 pubmed publisher
  11. Seney M, Goldman B, Forger N. Breeding status affects motoneuron number and muscle size in naked mole-rats: recruitment of perineal motoneurons?. J Neurobiol. 2006;66:1354-64 pubmed
    ..We propose that small, relatively undifferentiated cells are recruited to the pool of large Onuf's nucleus motoneurons when subordinate naked mole-rats become breeders...
  12. Green J, Inoue T, Sternberg P. Opposing Wnt pathways orient cell polarity during organogenesis. Cell. 2008;134:646-56 pubmed publisher
    ..Thus, tissue polarity is determined by the integration of multiple Wnt pathways...
  13. Rajakumar V, Chamberlin H. The Pax2/5/8 gene egl-38 coordinates organogenesis of the C. elegans egg-laying system. Dev Biol. 2007;301:240-53 pubmed
    ..As the Pax2 gene performs similar roles in the development of the mammalian kidney, we show that coordinating organogenesis is a conserved function for Pax2/5/8 transcription factors...
  14. Roy S, Clayton J, Holmen J, Beltz E, Saito R. Control of Cdc14 activity coordinates cell cycle and development in Caenorhabditis elegans. Mech Dev. 2011;128:317-26 pubmed publisher
    ..We propose that these mechanisms collaborate to restrict the activity of cdc-14 as central components of an evolutionarily conserved regulatory network to coordinate cell-cycle progression with development. ..
  15. Fernandes J, Sternberg P. The tailless ortholog nhr-67 regulates patterning of gene expression and morphogenesis in the C. elegans vulva. PLoS Genet. 2007;3:e69 pubmed
    ..We postulate that the differential levels and combinatorial patterns of lin-11, cog-1, and nhr-67 expression are a part of a regulatory code for the mature vulval cell types...
  16. Wang M, Sternberg P. Pattern formation during C. elegans vulval induction. Curr Top Dev Biol. 2001;51:189-220 pubmed
    ..The temporal and spatial regulation of VPC competence and production of the inductive and the lateral signal are precisely coordinated to ensure the wild-type vulval pattern...
  17. Holway A, Rieger Christ K, Miner W, Cain J, Dugan J, Pezza J, et al. Somatic mutation of PTEN in vulvar cancer. Clin Cancer Res. 2000;6:3228-35 pubmed
    ..These results suggest that PTEN is frequently altered in vulvar carcinomas and can be found associated with early dysplastic changes in vulvar mucosa. ..
  18. Chang C, Hopper N, Sternberg P. Caenorhabditis elegans SOS-1 is necessary for multiple RAS-mediated developmental signals. EMBO J. 2000;19:3283-94 pubmed
    ..This SOS-1-independent signaling is not inhibited by SLI-1/Cbl and is not mediated by PTP-2/SHP, raising the possibility that there could be another RasGEF...
  19. Felix M, Sternberg P. A gonad-derived survival signal for vulval precursor cells in two nematode species. Curr Biol. 1998;8:287-90 pubmed
    ..Our results demonstrate the existence of intercellular cell-survival signals in nematodes and uncover an evolutionary variation in the role of the gonad in nematode vulval development. ..
  20. Huang L, Tzou P, Sternberg P. The lin-15 locus encodes two negative regulators of Caenorhabditis elegans vulval development. Mol Biol Cell. 1994;5:395-411 pubmed
    ..We have identified a molecular null allele of lin-15 and have used it to analyze the role of lin-15 in the signaling pathway. We find that lin-15 acts upstream of let-23 and in parallel to the inductive signal. ..
  21. Jongeward G, Clandinin T, Sternberg P. sli-1, a negative regulator of let-23-mediated signaling in C. elegans. Genetics. 1995;139:1553-66 pubmed
    ..Our analysis suggests that let-23 can activate distinct signaling pathways in different tissues: one pathway is required for vulval induction; another pathway is involved in hermaphrodite fertility and is not regulated by sli-1...
  22. Avila J, Nicol K, Hewitt G, Matson S. Vulvar Fibroepithelial Polyps in a Female Adolescent: A Case Report. J Pediatr Adolesc Gynecol. 2017;30:595-597 pubmed publisher
    ..The spectrum of the morphology of FEPs might make their diagnosis challenging. We describe a rare presentation of vulvar FEPs in an adolescent girl receiving hormonal contraceptive therapy. ..
  23. Bae Y, Barr M. Sensory roles of neuronal cilia: cilia development, morphogenesis, and function in C. elegans. Front Biosci. 2008;13:5959-74 pubmed
    ..elegans identified the link between ciliary dysfunction and human ciliopathies. Future studies in the worm will address important basic questions regarding ciliary development, morphogenesis, specialization, and signaling functions. ..
  24. Pinkerton J, Bushmakin A, Komm B, Abraham L. Relationship between changes in vulvar-vaginal atrophy and changes in sexual functioning. Maturitas. 2017;100:57-63 pubmed publisher
    ..Changes in clinical parameters had only small or trivial associations with sexual functioning. Trial registration number NCT00238732. ..
  25. Ririe T, Fernandes J, Sternberg P. The Caenorhabditis elegans vulva: a post-embryonic gene regulatory network controlling organogenesis. Proc Natl Acad Sci U S A. 2008;105:20095-9 pubmed publisher
    ..These results provide an overview of the regulatory network architecture for each vulval cell type...
  26. Leclair C, Goetsch M, Korcheva V, Anderson R, Peters D, Morgan T. Differences in primary compared with secondary vestibulodynia by immunohistochemistry. Obstet Gynecol. 2011;117:1307-13 pubmed publisher
    ..53 CI 1.71-17.91). Primary and secondary vestibulodynia have significantly different histologic features, suggesting that they may have separate mechanistic pathways. Clinically, this may mean the discovery of distinct conditions. ..
  27. Ulm E, Sleiman S, Chamberlin H. Developmental functions for the Caenorhabditis elegans Sp protein SPTF-3. Mech Dev. 2011;128:428-41 pubmed publisher
    ..We propose SPTF-3 provides a good model to study the in vivo functions for Sp transcription factors during animal development. ..
  28. Sims S, Stinson K, McLean F, Davis J, Wilkinson E. Angiomyofibroblastoma of the vulva: a case report of a pedunculated variant and review of the literature. J Low Genit Tract Dis. 2012;16:149-54 pubmed publisher
    ..We reviewed 70 cases of vulvar AMF that have been reported in the English-language literature and report 1 case of a pedunculated variant. Our case brings the total reported to 71 and is only the fourth pedunculated variant reported...
  29. Kingsberg S, Wysocki S, Magnus L, Krychman M. Vulvar and vaginal atrophy in postmenopausal women: findings from the REVIVE (REal Women's VIews of Treatment Options for Menopausal Vaginal ChangEs) survey. J Sex Med. 2013;10:1790-9 pubmed publisher
    ..Symptoms include dyspareunia (pain with intercourse), vaginal dryness, and irritation and may affect sexual activities, relationships, and activities of daily life...
  30. Clayton J, van den Heuvel S, Saito R. Transcriptional control of cell-cycle quiescence during C. elegans development. Dev Biol. 2008;313:603-13 pubmed
    ..These transcriptional regulators represent potential molecular connections between development and the basic cell-cycle machinery. ..
  31. Aroian R, Koga M, Mendel J, Ohshima Y, Sternberg P. The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily. Nature. 1990;348:693-9 pubmed
  32. Aroian R, Sternberg P. Multiple functions of let-23, a Caenorhabditis elegans receptor tyrosine kinase gene required for vulval induction. Genetics. 1991;128:251-67 pubmed
    ..Since various let-23 mutant phenotypes can be obtained independently, the let-23 gene is likely to have tissue-specific functions. ..
  33. Lee J, Jongeward G, Sternberg P. unc-101, a gene required for many aspects of Caenorhabditis elegans development and behavior, encodes a clathrin-associated protein. Genes Dev. 1994;8:60-73 pubmed
    ..We have sequenced the mutant alleles of unc-101 identified in various genetic screens and shown that all but one are deletions or nonsense mutations, suggesting that these alleles severely reduce unc-101 function...
  34. Moghal N, Garcia L, Khan L, Iwasaki K, Sternberg P. Modulation of EGF receptor-mediated vulva development by the heterotrimeric G-protein Galphaq and excitable cells in C. elegans. Development. 2003;130:4553-66 pubmed
  35. Hwang B, Sternberg P. A cell-specific enhancer that specifies lin-3 expression in the C. elegans anchor cell for vulval development. Development. 2004;131:143-51 pubmed
  36. Bastiani C, Gharib S, Simon M, Sternberg P. Caenorhabditis elegans Galphaq regulates egg-laying behavior via a PLCbeta-independent and serotonin-dependent signaling pathway and likely functions both in the nervous system and in muscle. Genetics. 2003;165:1805-22 pubmed
    ..Our data indicate that there are multiple signaling pathways downstream of EGL-30 and that different pathways could predominate with respect to the regulation of different behaviors. ..
  37. Deshpande R, Inoue T, Priess J, Hill R. lin-17/Frizzled and lin-18 regulate POP-1/TCF-1 localization and cell type specification during C. elegans vulval development. Dev Biol. 2005;278:118-29 pubmed
    ..These experiments suggest that Wnt signaling pathways reorient cell lineages in the posterior half of the vulva from a default orientation displayed in the anterior half of the vulva. ..
  38. Bacon J, Burgis J. Hair thread tourniquet syndrome in adolescents: a presentation and review of the literature. J Pediatr Adolesc Gynecol. 2005;18:155-6 pubmed
    ..Prompt recognition of this unusual condition is essential for treatment of this potentially serious problem. ..
  39. Lee I, Lehner B, Crombie C, Wong W, Fraser A, Marcotte E. A single gene network accurately predicts phenotypic effects of gene perturbation in Caenorhabditis elegans. Nat Genet. 2008;40:181-8 pubmed publisher
    ..We conclude that an analogous network for human genes might be similarly predictive and thus facilitate identification of disease genes and rational therapeutic targets. ..
  40. Kamikura D, Cooper J. Lipoprotein receptors and a disabled family cytoplasmic adaptor protein regulate EGL-17/FGF export in C. elegans. Genes Dev. 2003;17:2798-811 pubmed
    ..These results suggest a model in which Ce-DAB-1 coordinates selection of receptors and cargo, including EGL-17, for transport through the secretory pathway. ..
  41. Karp X, Ambros V. Developmental biology. Encountering microRNAs in cell fate signaling. Science. 2005;310:1288-9 pubmed
  42. Moghal N, Sternberg P. A component of the transcriptional mediator complex inhibits RAS-dependent vulval fate specification in C. elegans. Development. 2003;130:57-69 pubmed
    ..Thus, the glutamine-rich region contributes to specificity of this class of mediator protein. ..
  43. Tazelaar H, Batts K, Srigley J. Primary extrapulmonary sugar tumor (PEST): a report of four cases. Mod Pathol. 2001;14:615-22 pubmed
  44. Chesney M, Kidd A, Kimble J. gon-14 functions with class B and class C synthetic multivulva genes to control larval growth in Caenorhabditis elegans. Genetics. 2006;172:915-28 pubmed
    ..We suggest that gon-14 functions with class B and class C synMuv genes to promote larval growth, in part by antagonizing MES-2,3,6/ESC-E(z) and MES-4. ..
  45. Walston T, Guo C, Proenca R, Wu M, Herman M, Hardin J, et al. mig-5/Dsh controls cell fate determination and cell migration in C. elegans. Dev Biol. 2006;298:485-97 pubmed
    ..These defects demonstrate that MIG-5 is essential in determining proper cell fate and cell migration throughout C. elegans development. ..
  46. Hill R, Sternberg P. The gene lin-3 encodes an inductive signal for vulval development in C. elegans. Nature. 1992;358:470-6 pubmed
    ..Expression of lin-3 in the anchor cell stimulates vulval induction; lin-3 may encode the vulval inducing signal...