Experts and Doctors on vldl lipoproteins in Germany
Topic: vldl lipoproteins
Nofer J, Junker R, Pulawski E, Fobker M, Levkau B, von Eckardstein A, et al
. High density lipoproteins induce cell cycle entry in vascular smooth muscle cells via mitogen activated protein kinase-dependent pathway. Thromb Haemost. 2001;85:730-5 pubmed
..The strong and specific mitogenic effect of HDL should be taken into account, when therapeutic strategies to elevate the plasma level of these lipoproteins are developed. ..
Klein S, Spannagl M, Engelmann B. Phosphatidylethanolamine participates in the stimulation of the contact system of coagulation by very-low-density lipoproteins. Arterioscler Thromb Vasc Biol. 2001;21:1695-700 pubmed
..In summary, VLDL stimulates the contact pathway of blood coagulation, ethanolamine phospholipids being the most active components of the particles. ..
Reinbold M, Hufnagel B, Kewitz T, Klumpp S, Krieglstein J. Unsaturated fatty acids liberated from VLDL cause apoptosis in endothelial cells. Mol Nutr Food Res. 2008;52:581-8 pubmed publisher
..In conclusion, our results show that the amounts of UFAs liberated from lipoproteins are high enough to induce apoptosis in endothelial cells. This underlines the proatherogenic role of UFAs in hyperlipoproteinemias. ..
Siech M, Zhou Z, Zhou S, Bair B, Alt A, Hamm S, et al
. Stimulation of stellate cells by injured acinar cells: a model of acute pancreatitis induced by alcohol and fat (VLDL). Am J Physiol Gastrointest Liver Physiol. 2009;297:G1163-71 pubmed publisher
Andersen O, Benhayon D, Curran T, Willnow T. Differential binding of ligands to the apolipoprotein E receptor 2. Biochemistry. 2003;42:9355-64 pubmed
..This finding indicates that aggregation of apoER2 by multivalent ligands such as Reelin may be the structural basis for signal transduction. ..
Ringseis R, Eder K. Dietary oxidized cholesterol decreases expression of hepatic microsomal triglyceride transfer protein in rats. J Nutr Biochem. 2004;15:103-11 pubmed
..In conclusion, the data of this study suggest, that dietary oxidized cholesterol affects VLDL assembly and/or secretion by reducing the synthesis of MTP but not by impairing hepatic lipogenesis or synthesis of apolipoprotein B. ..