Experts and Doctors on virulence in France


Locale: France
Topic: virulence

Top Publications

  1. Locht C. Molecular aspects of Bordetella pertussis pathogenesis. Int Microbiol. 1999;2:137-44 pubmed
    ..pertussis strains to be used as recombinant live bacterial vaccine vectors for homologous and heterologous protection. ..
  2. Candresse T, Gora Sochacka A, Zagorski W. Restoration of secondary hairpin II is associated with restoration of infectivity of a non-viable recombinant viroid. Virus Res. 2001;75:29-34 pubmed
    ..These results show that agro-infection is a suitable technique for the recovery of viable molecules from non-infectious viroid mutants and confirm that the ability to form secondary hairpin II is a prerequisite for viroid infectivity. ..
  3. Constant P, Perez E, Malaga W, Lanéelle M, Saurel O, Daffe M, et al. Role of the pks15/1 gene in the biosynthesis of phenolglycolipids in the Mycobacterium tuberculosis complex. Evidence that all strains synthesize glycosylated p-hydroxybenzoic methyl esters and that strains devoid of phenolglycolipids harbor a frames. J Biol Chem. 2002;277:38148-58 pubmed
    ..These data indicate that Pks15/1 is involved in the elongation of p-hydroxybenzoic acid to give p-hydroxyphenylalkanoates, which in turn are converted, presumably by the PpsA-E synthase, to phenolphthiocerol derivatives. ..
  4. Mavris M, Sansonetti P, Parsot C. Identification of the cis-acting site involved in activation of promoters regulated by activity of the type III secretion apparatus in Shigella flexneri. J Bacteriol. 2002;184:6751-9 pubmed
    ..We also present evidence that at least one ipaH gene that is carried by the chromosome is controlled by MxiE and IpgC...
  5. Rocha E. An appraisal of the potential for illegitimate recombination in bacterial genomes and its consequences: from duplications to genome reduction. Genome Res. 2003;13:1123-32 pubmed
    ..The assembly of these results indicates that shortly spaced repeats are key players in the dynamics of genome evolution. ..
  6. Fudal I, Böhnert H, Tharreau D, Lebrun M. Transposition of MINE, a composite retrotransposon, in the avirulence gene ACE1 of the rice blast fungus Magnaporthe grisea. Fungal Genet Biol. 2005;42:761-72 pubmed
    ..Such chimera could be formed during MGL reverse transcription as proposed for human U6-LINE1 chimeric retrotransposons and integrated into M. grisea genome using MGL machinery...
  7. Lopez Villavicencio M, Enjalbert J, Hood M, Shykoff J, Raquin C, Giraud T. The anther smut disease on Gypsophila repens: a case of parasite sub-optimal performance following a recent host shift?. J Evol Biol. 2005;18:1293-303 pubmed
    ..repens may thus represent an interesting case study for investigating the conditions leading to adaptation of parasites on new hosts...
  8. Girardeau J, Dalmasso A, Bertin Y, Ducrot C, Bord S, Livrelli V, et al. Association of virulence genotype with phylogenetic background in comparison to different seropathotypes of Shiga toxin-producing Escherichia coli isolates. J Clin Microbiol. 2005;43:6098-107 pubmed
    ..A practical benefit of our phylogenetic analysis of STEC strains is that phylogenetic group A status appears to be highly predictive of "nonvirulent" seropathotypes. ..
  9. Brodin P, Majlessi L, Marsollier L, de Jonge M, Bottai D, Demangel C, et al. Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence. Infect Immun. 2006;74:88-98 pubmed
    ..The present study has allowed us to identify new aspects of the extRD1 region of M. tuberculosis and to explore its role in the pathogenesis of tuberculosis. ..

More Information

Publications168 found, 100 shown here

  1. Zygmunt M, Hagius S, Walker J, Elzer P. Identification of Brucella melitensis 16M genes required for bacterial survival in the caprine host. Microbes Infect. 2006;8:2849-54 pubmed
    ..Other genes identified encoded factors involved in DNA metabolism and oxidoreduction metabolism. Using STM and the caprine host for screening, potential virulence determinants in B. melitensis have been identified. ..
  2. Carval D, Ferriere R. A unified model for the coevolution of resistance, tolerance, and virulence. Evolution. 2010;64:2988-3009 pubmed publisher
    ..quot; Implications for evolutionary management of infections are discussed and directions for future research are outlined. ..
  3. Aymeric J, Givaudan A, Duvic B. Imd pathway is involved in the interaction of Drosophila melanogaster with the entomopathogenic bacteria, Xenorhabdus nematophila and Photorhabdus luminescens. Mol Immunol. 2010;47:2342-8 pubmed publisher
    ..coli-induced protection. However, phoP recovered a level of pathogenicity comparable to P. luminescens wild-type TT01 when injected to Drosophila flies affected on the imd pathway. ..
  4. Mercier Delarue S, Durier C, Colin de Verdiere N, Poveda J, Meiffredy V, Fernandez Garcia M, et al. Screening test for neutralizing antibodies against yellow fever virus, based on a flavivirus pseudotype. PLoS ONE. 2017;12:e0177882 pubmed publisher
    ..This WN/YF17D test will be particularly useful for large epidemiological studies and for screening for neutralizing antibodies against yellow fever virus. ..
  5. Baillon L, Merour E, Cabon J, Louboutin L, Quenault H, Touzain F, et al. A single amino acid change in the non-structural NV protein impacts the virulence phenotype of Viral hemorrhagic septicemia virus in trout. J Gen Virol. 2017;98:1181-1184 pubmed publisher
    ..We showed that rVHSVNVR116S was highly attenuated and that surviving fish were almost completely protected from a challenge with the wild-type VHSV. ..
  6. Arellano Reynoso B, Lapaque N, Salcedo S, Briones G, Ciocchini A, Ugalde R, et al. Cyclic beta-1,2-glucan is a Brucella virulence factor required for intracellular survival. Nat Immunol. 2005;6:618-25 pubmed
    ..Brucella CbetaG is thus a virulence factor that interacts with lipid rafts and contributes to pathogen survival. ..
  7. Coutard F, Lozach S, Pommepuy M, Hervio Heath D. Real-time reverse transcription-PCR for transcriptional expression analysis of virulence and housekeeping genes in viable but nonculturable Vibrio parahaemolyticus after recovery of culturability. Appl Environ Microbiol. 2007;73:5183-9 pubmed
    ..This is the first time that the use of mRNA to detect viable cells was evaluated by computing the half-lives of multiple mRNA species under conditions inducing the VBNC state. ..
  8. Peros J, Berger G. Diversity within natural progenies of the grapevine dieback fungus Eutypa lata. Curr Genet. 1999;36:301-9 pubmed
    ..All the results were consistent with the hypothesis that E. lata is a random-mating species having a high degree of genetic diversity. ..
  9. Bierne H, Mazmanian S, Trost M, Pucciarelli M, Liu G, Dehoux P, et al. Inactivation of the srtA gene in Listeria monocytogenes inhibits anchoring of surface proteins and affects virulence. Mol Microbiol. 2002;43:869-81 pubmed
    ..Thus, L. monocytogenes srtA is required for the cell wall anchoring of InlA and, presumably, for the anchoring of other LPXTG-containing proteins that are involved in listerial infections...
  10. Benoit S, Benachour A, Taouji S, Auffray Y, Hartke A. H(2)O(2), which causes macrophage-related stress, triggers induction of expression of virulence-associated plasmid determinants in Rhodococcus equi. Infect Immun. 2002;70:3768-76 pubmed
  11. Rainard P, Corrales J, Barrio M, Cochard T, Poutrel B. Leucotoxic activities of Staphylococcus aureus strains isolated from cows, ewes, and goats with mastitis: importance of LukM/LukF'-PV leukotoxin. Clin Diagn Lab Immunol. 2003;10:272-7 pubmed
    ..They prompt further studies to delineate the contribution of LukM/LukF'-PV to the pathogenesis of mastitis in ruminants and the protective effect of antibodies to this leukotoxin. ..
  12. Gardan L, Stead D, Dauga C, Gillis M. Acidovorax valerianellae sp. nov., a novel pathogen of lamb's lettuce [Valerianella locusta (L.) Laterr]. Int J Syst Evol Microbiol. 2003;53:795-800 pubmed
    ..The name Acidovorax valerianellae sp. nov. is proposed for this novel taxon of phytopathogenic bacteria. The type strain is strain CFBP 4730(T) (= NCPPB 4283(T))...
  13. Bertin Y, Boukhors K, Livrelli V, Martin C. Localization of the insertion site and pathotype determination of the locus of enterocyte effacement of shiga toxin-producing Escherichia coli strains. Appl Environ Microbiol. 2004;70:61-8 pubmed
  14. Camus Bouclainville C, Fiette L, Bouchiha S, Pignolet B, Counor D, Filipe C, et al. A virulence factor of myxoma virus colocalizes with NF-kappaB in the nucleus and interferes with inflammation. J Virol. 2004;78:2510-6 pubmed
    ..Because MNF has homologs in other poxviruses, such as vaccinia, cowpox, and variola viruses, this protein is probably part of a key mechanism that contributes to the immunogenic and pathogenic properties of these viruses...
  15. Thomas F, Adamo S, Moore J. Parasitic manipulation: where are we and where should we go?. Behav Processes. 2005;68:185-99 pubmed
  16. Lavigne J, O Callaghan D, Blanc Potard A. Requirement of MgtC for Brucella suis intramacrophage growth: a potential mechanism shared by Salmonella enterica and Mycobacterium tuberculosis for adaptation to a low-Mg2+ environment. Infect Immun. 2005;73:3160-3 pubmed
    ..MgtC appears as a remarkable virulence factor that would have been acquired by distantly related intracellular pathogens to contribute to the adaptation to a low-Mg(2+) environment in the phagosome...
  17. Lesic B, Carniel E. Horizontal transfer of the high-pathogenicity island of Yersinia pseudotuberculosis. J Bacteriol. 2005;187:3352-8 pubmed
    ..This lateral transfer also involved the HPI-adjacent sequences, leading to the mobilization of a chromosomal region at least 46 kb in size. ..
  18. Parsot C. Shigella spp. and enteroinvasive Escherichia coli pathogenicity factors. FEMS Microbiol Lett. 2005;252:11-8 pubmed
    ..This review presents the current model on mechanisms of invasion of the colonic epithelium by these bacteria and focuses on their pathogenicity factors, particularly the virulence plasmid-encoded type III secretion system. ..
  19. Dubuisson J, Vianney A, Hugouvieux Cotte Pattat N, Lazzaroni J. Tol-Pal proteins are critical cell envelope components of Erwinia chrysanthemi affecting cell morphology and virulence. Microbiology. 2005;151:3337-47 pubmed
    ..This could be explained by a combination of impaired phenotypes in the tol-pal mutants, such as reduced growth and motility and a decreased production of pectate lyases, the major virulence factor of Er. chrysanthemi. ..
  20. Cornet M, Bidard F, Schwarz P, Da Costa G, Blanchin Roland S, Dromer F, et al. Deletions of endocytic components VPS28 and VPS32 affect growth at alkaline pH and virulence through both RIM101-dependent and RIM101-independent pathways in Candida albicans. Infect Immun. 2005;73:7977-87 pubmed
    ..Finally, in an in vivo mouse model, both vps null mutants were significantly less virulent than a rim101 mutant, suggesting that VPS28 and VPS32 gene products affect virulence both through Rim-dependent and Rim-independent pathways. ..
  21. Valls M, Genin S, Boucher C. Integrated regulation of the type III secretion system and other virulence determinants in Ralstonia solanacearum. PLoS Pathog. 2006;2:e82 pubmed
  22. Moury B, Fabre F, Senoussi R. Estimation of the number of virus particles transmitted by an insect vector. Proc Natl Acad Sci U S A. 2007;104:17891-6 pubmed
    ..Such narrow bottlenecks emphasize the strength of stochastic events acting on virus populations, and we illustrate, in modeling virus emergence, why estimating this parameter is important. ..
  23. Holzmuller P, Biron D, Courtois P, Koffi M, Bras Gonçalves R, Daulouede S, et al. Virulence and pathogenicity patterns of Trypanosoma brucei gambiense field isolates in experimentally infected mouse: differences in host immune response modulation by secretome and proteomics. Microbes Infect. 2008;10:79-86 pubmed
    ..This highlighted the potential involvement of the differential expression of the same genome in the diverse infectious properties of trypanosomes...
  24. Abi Khattar Z, Rejasse A, Destoumieux Garzón D, Escoubas J, Sanchis V, Lereclus D, et al. The dlt operon of Bacillus cereus is required for resistance to cationic antimicrobial peptides and for virulence in insects. J Bacteriol. 2009;191:7063-73 pubmed publisher
    ..cereus against insect humoral immune mediators, including hemolymph cationic AMPs, and may be critical for the establishment of lethal septicemia in insects and in nosocomial infections in humans. ..
  25. Soubies S, Volmer C, Croville G, Loupias J, Peralta B, Costes P, et al. Species-specific contribution of the four C-terminal amino acids of influenza A virus NS1 protein to virulence. J Virol. 2010;84:6733-47 pubmed publisher
    ..H7N1 virus with a C-terminal RSKV motif replicated to higher levels in ducks and induced higher levels of Mx, a type I interferon-stimulated gene. Thus, we identify the C-terminal domain of NS1 as a species-specific virulence domain. ..
  26. Marteyn B, Scorza F, Sansonetti P, Tang C. Breathing life into pathogens: the influence of oxygen on bacterial virulence and host responses in the gastrointestinal tract. Cell Microbiol. 2011;13:171-6 pubmed publisher
    ..Here we review the mechanisms bacterial pathogens utilize to sense oxygen within the gastrointestinal tract, and recent insights into how this acts as a signal to trigger virulence and to modulate host responses. ..
  27. Limmer S, Haller S, Drenkard E, Lee J, Yu S, Kocks C, et al. Pseudomonas aeruginosa RhlR is required to neutralize the cellular immune response in a Drosophila melanogaster oral infection model. Proc Natl Acad Sci U S A. 2011;108:17378-83 pubmed publisher
    ..These results illustrate the power of studying infection from the dual perspective of host and pathogen by revealing that RhlR plays a more complex role during pathogenesis than previously appreciated...
  28. van der Mee Marquet N, Corvaglia A, Valentin A, Hernandez D, Bertrand X, Girard M, et al. Analysis of prophages harbored by the human-adapted subpopulation of Staphylococcus aureus CC398. Infect Genet Evol. 2013;18:299-308 pubmed publisher
    ..aureus isolates. We demonstrate that functional prophage elements can condition host specificity and confer new virulence traits on emerging intra-species clones of bacteria. ..
  29. Bonanno L, Petit M, Loukiadis E, Michel V, Auvray F. Heterogeneity in Induction Level, Infection Ability, and Morphology of Shiga Toxin-Encoding Phages (Stx Phages) from Dairy and Human Shiga Toxin-Producing Escherichia coli O26:H11 Isolates. Appl Environ Microbiol. 2016;82:2177-2186 pubmed publisher
    ..coli O26:H11 to six Stx phages differed among the 17 strains tested and our attempts to convert them into STEC were unsuccessful, indicating that their lysogenization was a rare event. ..
  30. Loiseau L, Fyfe C, Aussel L, Hajj Chehade M, Hernández S, Faivre B, et al. The UbiK protein is an accessory factor necessary for bacterial ubiquinone (UQ) biosynthesis and forms a complex with the UQ biogenesis factor UbiJ. J Biol Chem. 2017;292:11937-11950 pubmed publisher
  31. Genin S, Gough C, Zischek C, Boucher C. Evidence that the hrpB gene encodes a positive regulator of pathogenicity genes from Pseudomonas solanacearum. Mol Microbiol. 1992;6:3065-76 pubmed
    ..We also show in this paper that the transcription of hrpB is induced in minimal medium and is partly autoregulated...
  32. Locht C, Antoine R, Jacob Dubuisson F. Bordetella pertussis, molecular pathogenesis under multiple aspects. Curr Opin Microbiol. 2001;4:82-9 pubmed
    ..They are regulated by iron, although in one case, the production of a siderophore receptor could be linked to the BvgAS regulon. ..
  33. Kohler S, Foulongne V, Ouahrani Bettache S, Bourg G, Teyssier J, Ramuz M, et al. The analysis of the intramacrophagic virulome of Brucella suis deciphers the environment encountered by the pathogen inside the macrophage host cell. Proc Natl Acad Sci U S A. 2002;99:15711-6 pubmed
    ..suis resides. We propose calling this specific compartment "brucellosome."..
  34. Seddas P, Boissinot S, Strub J, Van Dorsselaer A, Van Regenmortel M, Pattus F. Rack-1, GAPDH3, and actin: proteins of Myzus persicae potentially involved in the transcytosis of beet western yellows virus particles in the aphid. Virology. 2004;325:399-412 pubmed
    ..We hypothesize that three polypeptides, identified by mass spectrometry as Rack-1, GAPDH3, and actin, may be involved in the epithelial transcytosis of virus particles in the aphid vector...
  35. Coutard F, Pommepuy M, Loaec S, Hervio Heath D. mRNA detection by reverse transcription-PCR for monitoring viability and potential virulence in a pathogenic strain of Vibrio parahaemolyticus in viable but nonculturable state. J Appl Microbiol. 2005;98:951-61 pubmed
    ..Use of RT-PCR for investigating the maintenance or not of viability and potential virulence in VBNC V. parahaemolyticus will facilitate further study to evaluate the potential risk presented by this pathogen in the environment. ..
  36. Verneuil N, Rinc A, Sanguinetti M, Posteraro B, Fadda G, Auffray Y, et al. Contribution of a PerR-like regulator to the oxidative-stress response and virulence of Enterococcus faecalis. Microbiology. 2005;151:3997-4004 pubmed publisher
    ..The combined results show that PerR affects E. faecalis virulence and that its implication in the transcriptional regulation in this bacterium deviates from the B. subtilis model...
  37. Domelier A, van der Mee Marquet N, Grandet A, Mereghetti L, Rosenau A, Quentin R. Loss of catabolic function in Streptococcus agalactiae strains and its association with neonatal meningitis. J Clin Microbiol. 2006;44:3245-50 pubmed
    ..Identification of particular S. agalactiae biotypes may therefore be one of the criteria to assist clinicians in assessing the level of risk of neonatal meningitis when a mother and/or her neonate is colonized with S. agalactiae. ..
  38. de Chastellier C. The many niches and strategies used by pathogenic mycobacteria for survival within host macrophages. Immunobiology. 2009;214:526-42 pubmed publisher
    ..This overview highlights the major contribution of host cholesterol and/or fatty acids (triacylglycerol) in both prevention of phagosome maturation and persistence in granulomatous lesions. ..
  39. Rolland S, Bruel C, Rascle C, Girard V, Billon Grand G, Poussereau N. pH controls both transcription and post-translational processing of the protease BcACP1 in the phytopathogenic fungus Botrytis cinerea. Microbiology. 2009;155:2097-105 pubmed publisher
    ..Evidence is presented for an autocatalytic proteolysis of the enzyme that is triggered by acidic pH. Environmental pH therefore controls Bcacp1 production at both the transcriptional and post-translational level. ..
  40. Fournier P, El Karkouri K, Leroy Q, Robert C, Giumelli B, Renesto P, et al. Analysis of the Rickettsia africae genome reveals that virulence acquisition in Rickettsia species may be explained by genome reduction. BMC Genomics. 2009;10:166 pubmed publisher
    ..We also speculate that in Rickettsia species virulence is mostly associated with gene loss.The genome sequence was deposited in GenBank under accession number [GenBank: NZ_AAUY01000001]. ..
  41. van Schaik W, Château A, Dillies M, Coppee J, Sonenshein A, Fouet A. The global regulator CodY regulates toxin gene expression in Bacillus anthracis and is required for full virulence. Infect Immun. 2009;77:4437-45 pubmed publisher
    ..Overexpression of atxA restored toxin component synthesis in the codY mutant strain. These results suggest that CodY controls toxin gene expression by regulating AtxA accumulation posttranslationally. ..
  42. Daviet S, Van Borm S, Habyarimana A, Ahanda M, Morin V, Oudin A, et al. Induction of Mx and PKR failed to protect chickens from H5N1 infection. Viral Immunol. 2009;22:467-72 pubmed publisher
    ..This weak immune response, probably due in part to the absence of type I interferon, was not sufficient to counteract the hpH5N1 virus and protect the chicken from death. ..
  43. Biacchesi S, Lamoureux A, Merour E, Bernard J, Bremont M. Limited interference at the early stage of infection between two recombinant novirhabdoviruses: viral hemorrhagic septicemia virus and infectious hematopoietic necrosis virus. J Virol. 2010;84:10038-50 pubmed publisher
  44. Laouami S, Messaoudi K, Alberto F, Clavel T, Duport C. Lactate dehydrogenase A promotes communication between carbohydrate catabolism and virulence in Bacillus cereus. J Bacteriol. 2011;193:1757-66 pubmed publisher
    ..cereus. The data presented also provide evidence that LdhA-dependent regulation of enterotoxin gene expression is oxygen independent. This study is the first report to describe a role of a fermentative enzyme in virulence in B. cereus. ..
  45. Reffuveille F, Leneveu C, Chevalier S, Auffray Y, Rincé A. Lipoproteins of Enterococcus faecalis: bioinformatic identification, expression analysis and relation to virulence. Microbiology. 2011;157:3001-13 pubmed publisher
    ..Taken together, these data suggest a potential involvement of lipoproteins in E. faecalis virulence, making them serious candidates for vaccine production. ..
  46. Mhedbi Hajri N, Malfatti P, P dron J, Gaubert S, Reverchon S, Van Gijsegem F. PecS is an important player in the regulatory network governing the coordinated expression of virulence genes during the interaction between Dickeya dadantii 3937 and plants. Environ Microbiol. 2011;13:2901-14 pubmed publisher
  47. Mhedbi Hajri N, Hajri A, Boureau T, Darrasse A, Durand K, Brin C, et al. Evolutionary history of the plant pathogenic bacterium Xanthomonas axonopodis. PLoS ONE. 2013;8:e58474 pubmed publisher
    ..These transfers may have favored the emergence of novel pathotypes. Finally, we argue that the largest ecological entity within X. axonopodis is the pathovar. ..
  48. Flaugnatti N, Le T, Canaan S, Aschtgen M, Nguyen V, Blangy S, et al. A phospholipase A1 antibacterial Type VI secretion effector interacts directly with the C-terminal domain of the VgrG spike protein for delivery. Mol Microbiol. 2016;99:1099-118 pubmed publisher
    ..Based on these results, we propose an additional mechanism of transport of T6SS effectors in which cognate effectors are selected by specific motifs located at the C-terminus of VgrG proteins. ..
  49. Mock M, Fouet A. Anthrax. Annu Rev Microbiol. 2001;55:647-71 pubmed publisher
    ..Spore-structure analysis could contribute to the improvement of human nonliving vaccines. The phylogeny of B. anthracis within the Bacillus cereus group is also reviewed...
  50. Watt S, Lanotte P, Mereghetti L, Moulin Schouleur M, Picard B, Quentin R. Escherichia coli strains from pregnant women and neonates: intraspecies genetic distribution and prevalence of virulence factors. J Clin Microbiol. 2003;41:1929-35 pubmed
    ..These findings could serve as a basis for developing tools to recognize vaginal strains, which present a high risk for neonates, for use in prophylaxis programs...
  51. Stik G, Laurent S, Coupeau D, Coutaud B, Dambrine G, Rasschaert D, et al. A p53-dependent promoter associated with polymorphic tandem repeats controls the expression of a viral transcript encoding clustered microRNAs. RNA. 2010;16:2263-76 pubmed publisher
  52. Gladieux P, Guérin F, Giraud T, Caffier V, Lemaire C, Parisi L, et al. Emergence of novel fungal pathogens by ecological speciation: importance of the reduced viability of immigrants. Mol Ecol. 2011;20:4521-32 pubmed publisher
    ..Additional intrinsic and extrinsic postzygotic barriers might complete reproductive isolation and explain why the rare migrants and F1 hybrids detected do not lead to pervasive gene flow across years. ..
  53. Jaouannet M, Magliano M, Arguel M, Gourgues M, Evangelisti E, Abad P, et al. The root-knot nematode calreticulin Mi-CRT is a key effector in plant defense suppression. Mol Plant Microbe Interact. 2013;26:97-105 pubmed publisher
    ..Our results show that Mi-CRT secreted in the apoplasm by the nematode has a role in the suppression of plant basal defenses during the interaction...
  54. Sepulchre J, Reverchon S, Nasser W. Modeling the onset of virulence in a pectinolytic bacterium. J Theor Biol. 2007;244:239-57 pubmed
    ..This first modeling of the regulation of pel genes opens the way to new confrontations between theoretical ideas with experiments and possible strategies to fight the soft-rot disease of plants. ..
  55. Stinear T, Seemann T, Pidot S, Frigui W, Reysset G, Garnier T, et al. Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer. Genome Res. 2007;17:192-200 pubmed
    ..ulcerans and M. marinum. This work offers significant insight into the biology and evolution of mycobacterial pathogens and is an important component of international efforts to counter Buruli ulcer...
  56. Riboulet Bisson E, Sanguinetti M, Budin Verneuil A, Auffray Y, Hartke A, Giard J. Characterization of the Ers regulon of Enterococcus faecalis. Infect Immun. 2008;76:3064-74 pubmed publisher
    ..Taken together, these results indicate that the regulator Ers has a pleiotropic effect, especially in the cellular metabolism and virulence of E. faecalis. ..
  57. Yousef Mohamad K, Roche S, Myers G, Bavoil P, Laroucau K, Magnino S, et al. Preliminary phylogenetic identification of virulent Chlamydophila pecorum strains. Infect Genet Evol. 2008;8:764-71 pubmed publisher
    ..MVLST appears to be a promising method for the differential identification of virulent C. pecorum strains, and the ompA, incA and ORF663 genes appear to be good molecular markers for further epidemiological investigation of C. pecorum. ..
  58. Pihet M, Vandeputte P, Tronchin G, Renier G, Saulnier P, Georgeault S, et al. Melanin is an essential component for the integrity of the cell wall of Aspergillus fumigatus conidia. BMC Microbiol. 2009;9:177 pubmed publisher
  59. Chapuy Regaud S, Ogunniyi A, Diallo N, Huet Y, Desnottes J, Paton J, et al. RegR, a global LacI/GalR family regulator, modulates virulence and competence in Streptococcus pneumoniae. Infect Immun. 2003;71:2615-25 pubmed
    ..This LacI/GalR regulator, not essential for in vitro growth in rich media, is indeed involved in the adaptive response of the pneumococcus via its control of competence, adherence, and virulence. ..
  60. Chastanet A, Derre I, Nair S, Msadek T. clpB, a novel member of the Listeria monocytogenes CtsR regulon, is involved in virulence but not in general stress tolerance. J Bacteriol. 2004;186:1165-74 pubmed
    ..monocytogenes to lethal temperatures. This work gives the first example of a clpB gene directly controlled by CtsR and describes the first role for a ClpB protein in induced thermotolerance and virulence in a gram-positive organism...
  61. Dussurget O, Dumas E, Archambaud C, Chafsey I, Chambon C, Hebraud M, et al. Listeria monocytogenes ferritin protects against multiple stresses and is required for virulence. FEMS Microbiol Lett. 2005;250:253-61 pubmed
    ..A comparative proteomic analysis revealed an effect of the fri deletion on the levels of listeriolysin O and several stress proteins. Together, our study demonstrates that fri has multiple roles that contribute to Listeria virulence. ..
  62. Jackson M, Stadthagen G, Gicquel B. Long-chain multiple methyl-branched fatty acid-containing lipids of Mycobacterium tuberculosis: biosynthesis, transport, regulation and biological activities. Tuberculosis (Edinb). 2007;87:78-86 pubmed
  63. Garnier M, Labreuche Y, Nicolas J. Molecular and phenotypic characterization of Vibrio aestuarianus subsp. francensis subsp. nov., a pathogen of the oyster Crassostrea gigas. Syst Appl Microbiol. 2008;31:358-65 pubmed publisher
  64. Cheatsazan H, de Almedia A, Russell A, Bonneaud C. Experimental evidence for a cost of resistance to the fungal pathogen, Batrachochytrium dendrobatidis, for the palmate newt, Lissotriton helveticus. BMC Ecol. 2013;13:27 pubmed publisher
  65. Bingen E, Bonacorsi S, Brahimi N, Denamur E, Elion J. Virulence patterns of Escherichia coli K1 strains associated with neonatal meningitis. J Clin Microbiol. 1997;35:2981-2 pubmed
    ..coli K1 commensal strains, and 47 E. coli blood isolates from neonates without meningitis. ibe10, sfa, and the 14.9-kb HindIII fragment were observed significantly more often in the meningitis strains than in blood or commensal strains. ..
  66. Marches O, Nougayrede J, Boullier S, Mainil J, Charlier G, Raymond I, et al. Role of tir and intimin in the virulence of rabbit enteropathogenic Escherichia coli serotype O103:H2. Infect Immun. 2000;68:2171-82 pubmed
    ..In conclusion, we have confirmed the role of intimin in virulence, and we have shown, for the first time, that Tir is also a key factor in vivo for pathogenicity. ..
  67. Burkhardt S, Jiménez de Bagüés M, Liautard J, Kohler S. Analysis of the behavior of eryC mutants of Brucella suis attenuated in macrophages. Infect Immun. 2005;73:6782-90 pubmed
  68. Yamamoto Y, Pargade V, Lamberet G, Gaudu P, Thomas F, Texereau J, et al. The Group B Streptococcus NADH oxidase Nox-2 is involved in fatty acid biosynthesis during aerobic growth and contributes to virulence. Mol Microbiol. 2006;62:772-85 pubmed publisher
    ..As the nox2 defect seems only to affect aerobic growth of GBS, its reduced virulence supports the suggestion that aerobic conditions and NADH oxidase activities are relevant to the GBS infection process...
  69. Moyrand F, Lafontaine I, Fontaine T, Janbon G. UGE1 and UGE2 regulate the UDP-glucose/UDP-galactose equilibrium in Cryptococcus neoformans. Eukaryot Cell. 2008;7:2069-77 pubmed publisher
  70. Yan X, Zhao C, Budin Verneuil A, Hartke A, Rinc A, Gilmore M, et al. The (p)ppGpp synthetase RelA contributes to stress adaptation and virulence in Enterococcus faecalis V583. Microbiology. 2009;155:3226-37 pubmed publisher
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    ..The presence of the JHP947 gene was associated with the cagA-positive genotype. The JHP947 gene is a novel virulence marker candidate of H. pylori. ..
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    ..Even though ClpP plays a minor role in the virulence of S. agalactiae in a murine infection model, the data presented here point to the importance of ClpP in oxidative stress defence in preventing heat-induced cell alterations...
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    ..Such a dual regulation mediated by an alternative sigma factor of the TTSS appears to be a level of regulation between virulence and motility not yet described among Proteobacteria...
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    ..pylori. We propose a model in which these two nonredundant systems participate in H. pylori virulence by depleting gastric or immune cells from protective amino acids such as Gln and producing toxic ammonia close to the host cells...
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    ..Therefore, despite their loss in Y. pestis, five of the nine Y. pseudotuberculosis-specific chromosomal loci studied play a role in the survival, growth, or virulence of this species. ..
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