Genomes and Genes
Experts and Doctors on virulence in France
Publications168 found, 100 shown here
- Zygmunt M, Hagius S, Walker J, Elzer P. Identification of Brucella melitensis 16M genes required for bacterial survival in the caprine host. Microbes Infect. 2006;8:2849-54 pubmed..Other genes identified encoded factors involved in DNA metabolism and oxidoreduction metabolism. Using STM and the caprine host for screening, potential virulence determinants in B. melitensis have been identified. ..
- Carval D, Ferriere R. A unified model for the coevolution of resistance, tolerance, and virulence. Evolution. 2010;64:2988-3009 pubmed publisher..quot; Implications for evolutionary management of infections are discussed and directions for future research are outlined. ..
- Aymeric J, Givaudan A, Duvic B. Imd pathway is involved in the interaction of Drosophila melanogaster with the entomopathogenic bacteria, Xenorhabdus nematophila and Photorhabdus luminescens. Mol Immunol. 2010;47:2342-8 pubmed publisher..coli-induced protection. However, phoP recovered a level of pathogenicity comparable to P. luminescens wild-type TT01 when injected to Drosophila flies affected on the imd pathway. ..
- Mercier Delarue S, Durier C, Colin de Verdiere N, Poveda J, Meiffredy V, Fernandez Garcia M, et al. Screening test for neutralizing antibodies against yellow fever virus, based on a flavivirus pseudotype. PLoS ONE. 2017;12:e0177882 pubmed publisher..This WN/YF17D test will be particularly useful for large epidemiological studies and for screening for neutralizing antibodies against yellow fever virus. ..
- Baillon L, Merour E, Cabon J, Louboutin L, Quenault H, Touzain F, et al. A single amino acid change in the non-structural NV protein impacts the virulence phenotype of Viral hemorrhagic septicemia virus in trout. J Gen Virol. 2017;98:1181-1184 pubmed publisher..We showed that rVHSVNVR116S was highly attenuated and that surviving fish were almost completely protected from a challenge with the wild-type VHSV. ..
- Arellano Reynoso B, Lapaque N, Salcedo S, Briones G, Ciocchini A, Ugalde R, et al. Cyclic beta-1,2-glucan is a Brucella virulence factor required for intracellular survival. Nat Immunol. 2005;6:618-25 pubmed..Brucella CbetaG is thus a virulence factor that interacts with lipid rafts and contributes to pathogen survival. ..
- Coutard F, Lozach S, Pommepuy M, Hervio Heath D. Real-time reverse transcription-PCR for transcriptional expression analysis of virulence and housekeeping genes in viable but nonculturable Vibrio parahaemolyticus after recovery of culturability. Appl Environ Microbiol. 2007;73:5183-9 pubmed..This is the first time that the use of mRNA to detect viable cells was evaluated by computing the half-lives of multiple mRNA species under conditions inducing the VBNC state. ..
- Peros J, Berger G. Diversity within natural progenies of the grapevine dieback fungus Eutypa lata. Curr Genet. 1999;36:301-9 pubmed..All the results were consistent with the hypothesis that E. lata is a random-mating species having a high degree of genetic diversity. ..
- Bierne H, Mazmanian S, Trost M, Pucciarelli M, Liu G, Dehoux P, et al. Inactivation of the srtA gene in Listeria monocytogenes inhibits anchoring of surface proteins and affects virulence. Mol Microbiol. 2002;43:869-81 pubmed..Thus, L. monocytogenes srtA is required for the cell wall anchoring of InlA and, presumably, for the anchoring of other LPXTG-containing proteins that are involved in listerial infections...
- Benoit S, Benachour A, Taouji S, Auffray Y, Hartke A. H(2)O(2), which causes macrophage-related stress, triggers induction of expression of virulence-associated plasmid determinants in Rhodococcus equi. Infect Immun. 2002;70:3768-76 pubmed
- Rainard P, Corrales J, Barrio M, Cochard T, Poutrel B. Leucotoxic activities of Staphylococcus aureus strains isolated from cows, ewes, and goats with mastitis: importance of LukM/LukF'-PV leukotoxin. Clin Diagn Lab Immunol. 2003;10:272-7 pubmed..They prompt further studies to delineate the contribution of LukM/LukF'-PV to the pathogenesis of mastitis in ruminants and the protective effect of antibodies to this leukotoxin. ..
- Gardan L, Stead D, Dauga C, Gillis M. Acidovorax valerianellae sp. nov., a novel pathogen of lamb's lettuce [Valerianella locusta (L.) Laterr]. Int J Syst Evol Microbiol. 2003;53:795-800 pubmed..The name Acidovorax valerianellae sp. nov. is proposed for this novel taxon of phytopathogenic bacteria. The type strain is strain CFBP 4730(T) (= NCPPB 4283(T))...
- Bertin Y, Boukhors K, Livrelli V, Martin C. Localization of the insertion site and pathotype determination of the locus of enterocyte effacement of shiga toxin-producing Escherichia coli strains. Appl Environ Microbiol. 2004;70:61-8 pubmed
- Camus Bouclainville C, Fiette L, Bouchiha S, Pignolet B, Counor D, Filipe C, et al. A virulence factor of myxoma virus colocalizes with NF-kappaB in the nucleus and interferes with inflammation. J Virol. 2004;78:2510-6 pubmed..Because MNF has homologs in other poxviruses, such as vaccinia, cowpox, and variola viruses, this protein is probably part of a key mechanism that contributes to the immunogenic and pathogenic properties of these viruses...
- Thomas F, Adamo S, Moore J. Parasitic manipulation: where are we and where should we go?. Behav Processes. 2005;68:185-99 pubmed
- Lavigne J, O Callaghan D, Blanc Potard A. Requirement of MgtC for Brucella suis intramacrophage growth: a potential mechanism shared by Salmonella enterica and Mycobacterium tuberculosis for adaptation to a low-Mg2+ environment. Infect Immun. 2005;73:3160-3 pubmed..MgtC appears as a remarkable virulence factor that would have been acquired by distantly related intracellular pathogens to contribute to the adaptation to a low-Mg(2+) environment in the phagosome...
- Lesic B, Carniel E. Horizontal transfer of the high-pathogenicity island of Yersinia pseudotuberculosis. J Bacteriol. 2005;187:3352-8 pubmed..This lateral transfer also involved the HPI-adjacent sequences, leading to the mobilization of a chromosomal region at least 46 kb in size. ..
- Parsot C. Shigella spp. and enteroinvasive Escherichia coli pathogenicity factors. FEMS Microbiol Lett. 2005;252:11-8 pubmed..This review presents the current model on mechanisms of invasion of the colonic epithelium by these bacteria and focuses on their pathogenicity factors, particularly the virulence plasmid-encoded type III secretion system. ..
- Dubuisson J, Vianney A, Hugouvieux Cotte Pattat N, Lazzaroni J. Tol-Pal proteins are critical cell envelope components of Erwinia chrysanthemi affecting cell morphology and virulence. Microbiology. 2005;151:3337-47 pubmed..This could be explained by a combination of impaired phenotypes in the tol-pal mutants, such as reduced growth and motility and a decreased production of pectate lyases, the major virulence factor of Er. chrysanthemi. ..
- Cornet M, Bidard F, Schwarz P, Da Costa G, Blanchin Roland S, Dromer F, et al. Deletions of endocytic components VPS28 and VPS32 affect growth at alkaline pH and virulence through both RIM101-dependent and RIM101-independent pathways in Candida albicans. Infect Immun. 2005;73:7977-87 pubmed..Finally, in an in vivo mouse model, both vps null mutants were significantly less virulent than a rim101 mutant, suggesting that VPS28 and VPS32 gene products affect virulence both through Rim-dependent and Rim-independent pathways. ..
- Valls M, Genin S, Boucher C. Integrated regulation of the type III secretion system and other virulence determinants in Ralstonia solanacearum. PLoS Pathog. 2006;2:e82 pubmed
- Moury B, Fabre F, Senoussi R. Estimation of the number of virus particles transmitted by an insect vector. Proc Natl Acad Sci U S A. 2007;104:17891-6 pubmed..Such narrow bottlenecks emphasize the strength of stochastic events acting on virus populations, and we illustrate, in modeling virus emergence, why estimating this parameter is important. ..
- Holzmuller P, Biron D, Courtois P, Koffi M, Bras Gonçalves R, Daulouede S, et al. Virulence and pathogenicity patterns of Trypanosoma brucei gambiense field isolates in experimentally infected mouse: differences in host immune response modulation by secretome and proteomics. Microbes Infect. 2008;10:79-86 pubmed..This highlighted the potential involvement of the differential expression of the same genome in the diverse infectious properties of trypanosomes...
- Abi Khattar Z, Rejasse A, Destoumieux Garzón D, Escoubas J, Sanchis V, Lereclus D, et al. The dlt operon of Bacillus cereus is required for resistance to cationic antimicrobial peptides and for virulence in insects. J Bacteriol. 2009;191:7063-73 pubmed publisher..cereus against insect humoral immune mediators, including hemolymph cationic AMPs, and may be critical for the establishment of lethal septicemia in insects and in nosocomial infections in humans. ..
- Soubies S, Volmer C, Croville G, Loupias J, Peralta B, Costes P, et al. Species-specific contribution of the four C-terminal amino acids of influenza A virus NS1 protein to virulence. J Virol. 2010;84:6733-47 pubmed publisher..H7N1 virus with a C-terminal RSKV motif replicated to higher levels in ducks and induced higher levels of Mx, a type I interferon-stimulated gene. Thus, we identify the C-terminal domain of NS1 as a species-specific virulence domain. ..
- Marteyn B, Scorza F, Sansonetti P, Tang C. Breathing life into pathogens: the influence of oxygen on bacterial virulence and host responses in the gastrointestinal tract. Cell Microbiol. 2011;13:171-6 pubmed publisher..Here we review the mechanisms bacterial pathogens utilize to sense oxygen within the gastrointestinal tract, and recent insights into how this acts as a signal to trigger virulence and to modulate host responses. ..
- Limmer S, Haller S, Drenkard E, Lee J, Yu S, Kocks C, et al. Pseudomonas aeruginosa RhlR is required to neutralize the cellular immune response in a Drosophila melanogaster oral infection model. Proc Natl Acad Sci U S A. 2011;108:17378-83 pubmed publisher..These results illustrate the power of studying infection from the dual perspective of host and pathogen by revealing that RhlR plays a more complex role during pathogenesis than previously appreciated...
- van der Mee Marquet N, Corvaglia A, Valentin A, Hernandez D, Bertrand X, Girard M, et al. Analysis of prophages harbored by the human-adapted subpopulation of Staphylococcus aureus CC398. Infect Genet Evol. 2013;18:299-308 pubmed publisher..aureus isolates. We demonstrate that functional prophage elements can condition host specificity and confer new virulence traits on emerging intra-species clones of bacteria. ..
- Bonanno L, Petit M, Loukiadis E, Michel V, Auvray F. Heterogeneity in Induction Level, Infection Ability, and Morphology of Shiga Toxin-Encoding Phages (Stx Phages) from Dairy and Human Shiga Toxin-Producing Escherichia coli O26:H11 Isolates. Appl Environ Microbiol. 2016;82:2177-2186 pubmed publisher..coli O26:H11 to six Stx phages differed among the 17 strains tested and our attempts to convert them into STEC were unsuccessful, indicating that their lysogenization was a rare event. ..
- Genin S, Gough C, Zischek C, Boucher C. Evidence that the hrpB gene encodes a positive regulator of pathogenicity genes from Pseudomonas solanacearum. Mol Microbiol. 1992;6:3065-76 pubmed..We also show in this paper that the transcription of hrpB is induced in minimal medium and is partly autoregulated...
- Locht C, Antoine R, Jacob Dubuisson F. Bordetella pertussis, molecular pathogenesis under multiple aspects. Curr Opin Microbiol. 2001;4:82-9 pubmed..They are regulated by iron, although in one case, the production of a siderophore receptor could be linked to the BvgAS regulon. ..
- Kohler S, Foulongne V, Ouahrani Bettache S, Bourg G, Teyssier J, Ramuz M, et al. The analysis of the intramacrophagic virulome of Brucella suis deciphers the environment encountered by the pathogen inside the macrophage host cell. Proc Natl Acad Sci U S A. 2002;99:15711-6 pubmed..suis resides. We propose calling this specific compartment "brucellosome."..
- Seddas P, Boissinot S, Strub J, Van Dorsselaer A, Van Regenmortel M, Pattus F. Rack-1, GAPDH3, and actin: proteins of Myzus persicae potentially involved in the transcytosis of beet western yellows virus particles in the aphid. Virology. 2004;325:399-412 pubmed..We hypothesize that three polypeptides, identified by mass spectrometry as Rack-1, GAPDH3, and actin, may be involved in the epithelial transcytosis of virus particles in the aphid vector...
- Coutard F, Pommepuy M, Loaec S, Hervio Heath D. mRNA detection by reverse transcription-PCR for monitoring viability and potential virulence in a pathogenic strain of Vibrio parahaemolyticus in viable but nonculturable state. J Appl Microbiol. 2005;98:951-61 pubmed..Use of RT-PCR for investigating the maintenance or not of viability and potential virulence in VBNC V. parahaemolyticus will facilitate further study to evaluate the potential risk presented by this pathogen in the environment. ..
- Verneuil N, Rinc A, Sanguinetti M, Posteraro B, Fadda G, Auffray Y, et al. Contribution of a PerR-like regulator to the oxidative-stress response and virulence of Enterococcus faecalis. Microbiology. 2005;151:3997-4004 pubmed publisher..The combined results show that PerR affects E. faecalis virulence and that its implication in the transcriptional regulation in this bacterium deviates from the B. subtilis model...
- Domelier A, van der Mee Marquet N, Grandet A, Mereghetti L, Rosenau A, Quentin R. Loss of catabolic function in Streptococcus agalactiae strains and its association with neonatal meningitis. J Clin Microbiol. 2006;44:3245-50 pubmed..Identification of particular S. agalactiae biotypes may therefore be one of the criteria to assist clinicians in assessing the level of risk of neonatal meningitis when a mother and/or her neonate is colonized with S. agalactiae. ..
- de Chastellier C. The many niches and strategies used by pathogenic mycobacteria for survival within host macrophages. Immunobiology. 2009;214:526-42 pubmed publisher..This overview highlights the major contribution of host cholesterol and/or fatty acids (triacylglycerol) in both prevention of phagosome maturation and persistence in granulomatous lesions. ..
- Rolland S, Bruel C, Rascle C, Girard V, Billon Grand G, Poussereau N. pH controls both transcription and post-translational processing of the protease BcACP1 in the phytopathogenic fungus Botrytis cinerea. Microbiology. 2009;155:2097-105 pubmed publisher..Evidence is presented for an autocatalytic proteolysis of the enzyme that is triggered by acidic pH. Environmental pH therefore controls Bcacp1 production at both the transcriptional and post-translational level. ..
- Fournier P, El Karkouri K, Leroy Q, Robert C, Giumelli B, Renesto P, et al. Analysis of the Rickettsia africae genome reveals that virulence acquisition in Rickettsia species may be explained by genome reduction. BMC Genomics. 2009;10:166 pubmed publisher..We also speculate that in Rickettsia species virulence is mostly associated with gene loss.The genome sequence was deposited in GenBank under accession number [GenBank: NZ_AAUY01000001]. ..
- van Schaik W, Château A, Dillies M, Coppee J, Sonenshein A, Fouet A. The global regulator CodY regulates toxin gene expression in Bacillus anthracis and is required for full virulence. Infect Immun. 2009;77:4437-45 pubmed publisher..Overexpression of atxA restored toxin component synthesis in the codY mutant strain. These results suggest that CodY controls toxin gene expression by regulating AtxA accumulation posttranslationally. ..
- Daviet S, Van Borm S, Habyarimana A, Ahanda M, Morin V, Oudin A, et al. Induction of Mx and PKR failed to protect chickens from H5N1 infection. Viral Immunol. 2009;22:467-72 pubmed publisher..This weak immune response, probably due in part to the absence of type I interferon, was not sufficient to counteract the hpH5N1 virus and protect the chicken from death. ..
- Laouami S, Messaoudi K, Alberto F, Clavel T, Duport C. Lactate dehydrogenase A promotes communication between carbohydrate catabolism and virulence in Bacillus cereus. J Bacteriol. 2011;193:1757-66 pubmed publisher..cereus. The data presented also provide evidence that LdhA-dependent regulation of enterotoxin gene expression is oxygen independent. This study is the first report to describe a role of a fermentative enzyme in virulence in B. cereus. ..
- Reffuveille F, Leneveu C, Chevalier S, Auffray Y, Rincé A. Lipoproteins of Enterococcus faecalis: bioinformatic identification, expression analysis and relation to virulence. Microbiology. 2011;157:3001-13 pubmed publisher..Taken together, these data suggest a potential involvement of lipoproteins in E. faecalis virulence, making them serious candidates for vaccine production. ..
- Mhedbi Hajri N, Malfatti P, P dron J, Gaubert S, Reverchon S, Van Gijsegem F. PecS is an important player in the regulatory network governing the coordinated expression of virulence genes during the interaction between Dickeya dadantii 3937 and plants. Environ Microbiol. 2011;13:2901-14 pubmed publisher
- Mhedbi Hajri N, Hajri A, Boureau T, Darrasse A, Durand K, Brin C, et al. Evolutionary history of the plant pathogenic bacterium Xanthomonas axonopodis. PLoS ONE. 2013;8:e58474 pubmed publisher..These transfers may have favored the emergence of novel pathotypes. Finally, we argue that the largest ecological entity within X. axonopodis is the pathovar. ..
- Flaugnatti N, Le T, Canaan S, Aschtgen M, Nguyen V, Blangy S, et al. A phospholipase A1 antibacterial Type VI secretion effector interacts directly with the C-terminal domain of the VgrG spike protein for delivery. Mol Microbiol. 2016;99:1099-118 pubmed publisher..Based on these results, we propose an additional mechanism of transport of T6SS effectors in which cognate effectors are selected by specific motifs located at the C-terminus of VgrG proteins. ..
- ..Spore-structure analysis could contribute to the improvement of human nonliving vaccines. The phylogeny of B. anthracis within the Bacillus cereus group is also reviewed...
- Watt S, Lanotte P, Mereghetti L, Moulin Schouleur M, Picard B, Quentin R. Escherichia coli strains from pregnant women and neonates: intraspecies genetic distribution and prevalence of virulence factors. J Clin Microbiol. 2003;41:1929-35 pubmed..These findings could serve as a basis for developing tools to recognize vaginal strains, which present a high risk for neonates, for use in prophylaxis programs...
- Gladieux P, Guérin F, Giraud T, Caffier V, Lemaire C, Parisi L, et al. Emergence of novel fungal pathogens by ecological speciation: importance of the reduced viability of immigrants. Mol Ecol. 2011;20:4521-32 pubmed publisher..Additional intrinsic and extrinsic postzygotic barriers might complete reproductive isolation and explain why the rare migrants and F1 hybrids detected do not lead to pervasive gene flow across years. ..
- Jaouannet M, Magliano M, Arguel M, Gourgues M, Evangelisti E, Abad P, et al. The root-knot nematode calreticulin Mi-CRT is a key effector in plant defense suppression. Mol Plant Microbe Interact. 2013;26:97-105 pubmed publisher..Our results show that Mi-CRT secreted in the apoplasm by the nematode has a role in the suppression of plant basal defenses during the interaction...
- Sepulchre J, Reverchon S, Nasser W. Modeling the onset of virulence in a pectinolytic bacterium. J Theor Biol. 2007;244:239-57 pubmed..This first modeling of the regulation of pel genes opens the way to new confrontations between theoretical ideas with experiments and possible strategies to fight the soft-rot disease of plants. ..
- Stinear T, Seemann T, Pidot S, Frigui W, Reysset G, Garnier T, et al. Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer. Genome Res. 2007;17:192-200 pubmed..ulcerans and M. marinum. This work offers significant insight into the biology and evolution of mycobacterial pathogens and is an important component of international efforts to counter Buruli ulcer...
- Riboulet Bisson E, Sanguinetti M, Budin Verneuil A, Auffray Y, Hartke A, Giard J. Characterization of the Ers regulon of Enterococcus faecalis. Infect Immun. 2008;76:3064-74 pubmed publisher..Taken together, these results indicate that the regulator Ers has a pleiotropic effect, especially in the cellular metabolism and virulence of E. faecalis. ..
- Yousef Mohamad K, Roche S, Myers G, Bavoil P, Laroucau K, Magnino S, et al. Preliminary phylogenetic identification of virulent Chlamydophila pecorum strains. Infect Genet Evol. 2008;8:764-71 pubmed publisher..MVLST appears to be a promising method for the differential identification of virulent C. pecorum strains, and the ompA, incA and ORF663 genes appear to be good molecular markers for further epidemiological investigation of C. pecorum. ..
- Chapuy Regaud S, Ogunniyi A, Diallo N, Huet Y, Desnottes J, Paton J, et al. RegR, a global LacI/GalR family regulator, modulates virulence and competence in Streptococcus pneumoniae. Infect Immun. 2003;71:2615-25 pubmed..This LacI/GalR regulator, not essential for in vitro growth in rich media, is indeed involved in the adaptive response of the pneumococcus via its control of competence, adherence, and virulence. ..
- Chastanet A, Derre I, Nair S, Msadek T. clpB, a novel member of the Listeria monocytogenes CtsR regulon, is involved in virulence but not in general stress tolerance. J Bacteriol. 2004;186:1165-74 pubmed..monocytogenes to lethal temperatures. This work gives the first example of a clpB gene directly controlled by CtsR and describes the first role for a ClpB protein in induced thermotolerance and virulence in a gram-positive organism...
- Dussurget O, Dumas E, Archambaud C, Chafsey I, Chambon C, Hebraud M, et al. Listeria monocytogenes ferritin protects against multiple stresses and is required for virulence. FEMS Microbiol Lett. 2005;250:253-61 pubmed..A comparative proteomic analysis revealed an effect of the fri deletion on the levels of listeriolysin O and several stress proteins. Together, our study demonstrates that fri has multiple roles that contribute to Listeria virulence. ..
- Jackson M, Stadthagen G, Gicquel B. Long-chain multiple methyl-branched fatty acid-containing lipids of Mycobacterium tuberculosis: biosynthesis, transport, regulation and biological activities. Tuberculosis (Edinb). 2007;87:78-86 pubmed
- Bingen E, Bonacorsi S, Brahimi N, Denamur E, Elion J. Virulence patterns of Escherichia coli K1 strains associated with neonatal meningitis. J Clin Microbiol. 1997;35:2981-2 pubmed..coli K1 commensal strains, and 47 E. coli blood isolates from neonates without meningitis. ibe10, sfa, and the 14.9-kb HindIII fragment were observed significantly more often in the meningitis strains than in blood or commensal strains. ..
- Marches O, Nougayrede J, Boullier S, Mainil J, Charlier G, Raymond I, et al. Role of tir and intimin in the virulence of rabbit enteropathogenic Escherichia coli serotype O103:H2. Infect Immun. 2000;68:2171-82 pubmed..In conclusion, we have confirmed the role of intimin in virulence, and we have shown, for the first time, that Tir is also a key factor in vivo for pathogenicity. ..
- Burkhardt S, Jiménez de Bagüés M, Liautard J, Kohler S. Analysis of the behavior of eryC mutants of Brucella suis attenuated in macrophages. Infect Immun. 2005;73:6782-90 pubmed..suis...
- Yamamoto Y, Pargade V, Lamberet G, Gaudu P, Thomas F, Texereau J, et al. The Group B Streptococcus NADH oxidase Nox-2 is involved in fatty acid biosynthesis during aerobic growth and contributes to virulence. Mol Microbiol. 2006;62:772-85 pubmed publisher..As the nox2 defect seems only to affect aerobic growth of GBS, its reduced virulence supports the suggestion that aerobic conditions and NADH oxidase activities are relevant to the GBS infection process...
- Yan X, Zhao C, Budin Verneuil A, Hartke A, Rinc A, Gilmore M, et al. The (p)ppGpp synthetase RelA contributes to stress adaptation and virulence in Enterococcus faecalis V583. Microbiology. 2009;155:3226-37 pubmed publisher..This virulent phenotype should stem from its increased ability to proliferate under oxidative environments...
- Dalmais B, Schumacher J, Moraga J, Le Pêcheur P, Tudzynski B, Collado I, et al. The Botrytis cinerea phytotoxin botcinic acid requires two polyketide synthases for production and has a redundant role in virulence with botrydial. Mol Plant Pathol. 2011;12:564-79 pubmed publisher..However, double mutants that do not produce botcinic acid or botrydial (bcpks6Δbcbot2Δ) exhibit markedly reduced virulence. Hence, a redundant role of botrydial and botcinic acid in the virulence of B. cinerea has been demonstrated. ..
- Danne C, Dramsi S. Pili of gram-positive bacteria: roles in host colonization. Res Microbiol. 2012;163:645-58 pubmed publisher..This overview should help to understand the rise of pili as an intensive field of investigation and pinpoints the areas that need further study. ..
- Peiffer I, Bernet Camard M, Rousset M, Servin A. Impairments in enzyme activity and biosynthesis of brush border-associated hydrolases in human intestinal Caco-2/TC7 cells infected by members of the Afa/Dr family of diffusely adhering Escherichia coli. Cell Microbiol. 2001;3:341-57 pubmed..Moreover, the results revealed that other pathogenic factor(s) distinct from the Afa/Dr adhesins may play(s) a crucial role in this mechanism of pathogenicity. ..
- Santos A, Queiroz D, Menard A, Marais A, Rocha G, Oliveira C, et al. New pathogenicity marker found in the plasticity region of the Helicobacter pylori genome. J Clin Microbiol. 2003;41:1651-5 pubmed..The presence of the JHP947 gene was associated with the cagA-positive genotype. The JHP947 gene is a novel virulence marker candidate of H. pylori. ..
- Salhi I, Boigegrain R, Machold J, Weise C, Cloeckaert A, Rouot B. Characterization of new members of the group 3 outer membrane protein family of Brucella spp. Infect Immun. 2003;71:4326-32 pubmed..suis or in other Brucella species and we propose a nomenclature that integrates all of these proteins to facilitate the understanding of future Brucella interspecies study results. ..
- Ponton F, Lebarbenchon C, Lefevre T, Biron D, Duneau D, Hughes D, et al. Parasitology: parasite survives predation on its host. Nature. 2006;440:756 pubmed..This remarkable tactic enables the worm to continue its life cycle. ..
- Moyrand F, Fontaine T, Janbon G. Systematic capsule gene disruption reveals the central role of galactose metabolism on Cryptococcus neoformans virulence. Mol Microbiol. 2007;64:771-81 pubmed
- Pradel E, Guiso N, Menozzi F, Locht C. Bordetella pertussis TonB, a Bvg-independent virulence determinant. Infect Immun. 2000;68:1919-27 pubmed..Nevertheless, in vivo in the mouse respiratory infection model, the colonization ability of the mutant was reduced compared to the parental strain...
- Nair S, Poyart C, Beretti J, Veiga Fernandes H, Berche P, Trieu Cuot P. Role of the Streptococcus agalactiae ClpP serine protease in heat-induced stress defence and growth arrest. Microbiology. 2003;149:407-17 pubmed publisher..Even though ClpP plays a minor role in the virulence of S. agalactiae in a murine infection model, the data presented here point to the importance of ClpP in oxidative stress defence in preventing heat-induced cell alterations...
- Cesbron S, Paulin J, Tharaud M, Barny M, Brisset M. The alternative sigma factor HrpL negatively modulates the flagellar system in the phytopathogenic bacterium Erwinia amylovora under hrp-inducing conditions. FEMS Microbiol Lett. 2006;257:221-7 pubmed..Such a dual regulation mediated by an alternative sigma factor of the TTSS appears to be a level of regulation between virulence and motility not yet described among Proteobacteria...
- Jamet A, Rousseau C, Monfort J, Frapy E, Nassif X, Martin P. A two-component system is required for colonization of host cells by meningococcus. Microbiology. 2009;155:2288-95 pubmed publisher..Thus, we provide evidence that one of the four TCSs existing in N. meningitidis contributes to the adaptation of the pathogen to growth on host cells. ..
- Leduc D, Gallaud J, Stingl K, De Reuse H. Coupled amino acid deamidase-transport systems essential for Helicobacter pylori colonization. Infect Immun. 2010;78:2782-92 pubmed publisher..pylori. We propose a model in which these two nonredundant systems participate in H. pylori virulence by depleting gastric or immune cells from protective amino acids such as Gln and producing toxic ammonia close to the host cells...
- Dumoulin R, Cortes Perez N, Gaubert S, Duhutrel P, Brinster S, Torelli R, et al. Enterococcal Rgg-like regulator ElrR activates expression of the elrA operon. J Bacteriol. 2013;195:3073-83 pubmed publisher..Virulence of simple and double elrR and elrA deletion mutants also suggests a remaining ElrR-independent expression of elrA in vivo and additional virulence-related genes controlled by ElrR. ..
- Pouillot F, Fayolle C, Carniel E. Characterization of chromosomal regions conserved in Yersinia pseudotuberculosis and lost by Yersinia pestis. Infect Immun. 2008;76:4592-9 pubmed publisher..Therefore, despite their loss in Y. pestis, five of the nine Y. pseudotuberculosis-specific chromosomal loci studied play a role in the survival, growth, or virulence of this species. ..
- Hebrard E, Poulicard N, Gérard C, Traore O, Wu H, Albar L, et al. Direct interaction between the Rice yellow mottle virus (RYMV) VPg and the central domain of the rice eIF(iso)4G1 factor correlates with rice susceptibility and RYMV virulence. Mol Plant Microbe Interact. 2010;23:1506-13 pubmed publisher..Finally, the strategies of RYMV and members of family Potyviridae to overcome recessive resistance were compared. ..
- Kühbacher A, Dambournet D, Echard A, Cossart P, Pizarro Cerda J. Phosphatidylinositol 5-phosphatase oculocerebrorenal syndrome of Lowe protein (OCRL) controls actin dynamics during early steps of Listeria monocytogenes infection. J Biol Chem. 2012;287:13128-36 pubmed publisher..monocytogenes and of actin associated with invading bacteria. These results demonstrate that through its phosphatase activity, OCRL restricts L. monocytogenes invasion by modulating actin dynamics at bacterial internalization sites. ..
- Haddad N, Tresse O, Rivoal K, Chevret D, Nonglaton Q, Burns C, et al. Polynucleotide phosphorylase has an impact on cell biology of Campylobacter jejuni. Front Cell Infect Microbiol. 2012;2:30 pubmed publisher..jejuni. In conclusion, PNPase deficiency induces limited but important consequences on C. jejuni biology that could explain swimming limitation, chick colonization delay, and the decrease of cell adhesion/invasion ability. ..
- Colinet D, Mathé Hubert H, Allemand R, Gatti J, Poirié M. Variability of venom components in immune suppressive parasitoid wasps: from a phylogenetic to a population approach. J Insect Physiol. 2013;59:205-12 pubmed publisher..Whether occurrence of such variability may permit a selection of parasitoid venom components driven by the host remains to be tested, notably in the context of the production and use of biological control auxiliaries...
- Yockteng R, Marthey S, Chiapello H, Gendrault A, Hood M, Rodolphe F, et al. Expressed sequences tags of the anther smut fungus, Microbotryum violaceum, identify mating and pathogenicity genes. BMC Genomics. 2007;8:272 pubmed..This study provides a basis for cloning the mating type locus, for further investigation of pathogenicity genes in the anther smut fungi, and for comparative genomics. ..
- Debarbouille M, Dramsi S, Dussurget O, Nahori M, Vaganay E, Jouvion G, et al. Characterization of a serine/threonine kinase involved in virulence of Staphylococcus aureus. J Bacteriol. 2009;191:4070-81 pubmed publisher..These results confirm the important role of Stk1 for full expression of S. aureus pathogenesis and suggest that phosphorylation levels controlled by stk1 are essential in controlling bacterial survival within the host. ..
- Dubois D, Prasadarao N, Mittal R, Bret L, Roujou Gris M, Bonnet R. CTX-M beta-lactamase production and virulence of Escherichia coli K1. Emerg Infect Dis. 2009;15:1988-90 pubmed publisher..The influence of CTX-M production on virulence was investigated in cell culture and a newborn mouse model of meningitis. CTX-M production had no influence on virulence but was a major factor in clinical outcome. ..
- Fouet A. AtxA, a Bacillus anthracis global virulence regulator. Res Microbiol. 2010;161:735-42 pubmed publisher..The expression of many AtxA-controlled genes is induced by the presence of bicarbonate/CO(2). AtxA links the metabolic state and virulence gene expression. ..