Experts and Doctors on viral proteins in United States

Summary

Locale: United States
Topic: viral proteins

Top Publications

  1. Mallory A, Ely L, Smith T, Marathe R, Anandalakshmi R, Fagard M, et al. HC-Pro suppression of transgene silencing eliminates the small RNAs but not transgene methylation or the mobile signal. Plant Cell. 2001;13:571-83 pubmed
    ..These results demonstrate that HC-Pro functions downstream of transgene methylation and the mobile signal at a step preceding accumulation of the small RNAs. ..
  2. van Wezel R, Liu H, Tien P, Stanley J, Hong Y. Gene C2 of the monopartite geminivirus tomato yellow leaf curl virus-China encodes a pathogenicity determinant that is localized in the nucleus. Mol Plant Microbe Interact. 2001;14:1125-8 pubmed
    ..Our data demonstrate that the TYLCV-C C2 protein may contribute to viral pathogenicity in planta and is nuclear localized...
  3. Hötzel I, Cheevers W. Caprine arthritis-encephalitis virus envelope surface glycoprotein regions interacting with the transmembrane glycoprotein: structural and functional parallels with human immunodeficiency virus type 1 gp120. J Virol. 2003;77:11578-87 pubmed
    ..Our results indicate structural and functional parallels between CAEV gp135 and HIV-1 gp120 that may be more broadly applicable to the SU of other lentiviruses. ..
  4. Strand M, Beck M, Lavine M, Clark K. Microplitis demolitor bracovirus inhibits phagocytosis by hemocytes from Pseudoplusia includens. Arch Insect Biochem Physiol. 2006;61:134-45 pubmed
    ..Collectively, these results indicate that glc1.8 is a key virulence determinant in disruption of both adhesion and phagocytosis by insect immune cells. ..
  5. Ausar S, Foubert T, Hudson M, Vedvick T, Middaugh C. Conformational stability and disassembly of Norwalk virus-like particles. Effect of pH and temperature. J Biol Chem. 2006;281:19478-88 pubmed
    ..Complementary, differential scanning calorimetric analyses suggest that the two domains of VP1 unfold independently in a pH-dependent manner. ..
  6. Saffert R, Kalejta R. Human cytomegalovirus gene expression is silenced by Daxx-mediated intrinsic immune defense in model latent infections established in vitro. J Virol. 2007;81:9109-20 pubmed
    ..This identifies Daxx as one of the likely multiple viral and cellular determinants in the pathway of HCMV quiescence in vitro, and perhaps in natural latent infections as well. ..
  7. Jaag H, Stork J, Nagy P. Host transcription factor Rpb11p affects tombusvirus replication and recombination via regulating the accumulation of viral replication proteins. Virology. 2007;368:388-404 pubmed publisher
    ..We propose a model that the concentration (molecular crowding) of replication proteins within the viral replicase is a factor affecting viral replication and recombination...
  8. Palmeri D, Spadavecchia S, Carroll K, Lukac D. Promoter- and cell-specific transcriptional transactivation by the Kaposi's sarcoma-associated herpesvirus ORF57/Mta protein. J Virol. 2007;81:13299-314 pubmed
    ..We propose that one molecular mechanism of Mta-mediated transactivation is a direct effect on transcription by direct and indirect promoter association. ..
  9. Li Z, Barajas D, Panavas T, Herbst D, Nagy P. Cdc34p ubiquitin-conjugating enzyme is a component of the tombusvirus replicase complex and ubiquitinates p33 replication protein. J Virol. 2008;82:6911-26 pubmed publisher
    ..In addition, we have shown that p33 becomes ubiquitinated in vivo. We propose that ubiquitination of p33 likely alters its function or affects the recruitment of host factors during TBSV replication...

More Information

Publications308 found, 100 shown here

  1. Tracy E, Ye F, Baker B, Munson R. Construction of non-polar mutants in Haemophilus influenzae using FLP recombinase technology. BMC Mol Biol. 2008;9:101 pubmed publisher
    ..Utilization of this approach allowed us to readily generate unmarked non-polar mutations in NTHi genes. ..
  2. Mendu V, Chiu M, Barajas D, Li Z, Nagy P. Cpr1 cyclophilin and Ess1 parvulin prolyl isomerases interact with the tombusvirus replication protein and inhibit viral replication in yeast model host. Virology. 2010;406:342-51 pubmed publisher
    ..We also show that the Ess1p parvulin prolyl isomerase partly complements Cpr1p function as an inhibitor of tombusvirus replication...
  3. Bhoumik P, Hughes A. Reassortment of ancient neuraminidase and recent hemagglutinin in pandemic (H1N1) 2009 virus. Emerg Infect Dis. 2010;16:1748-50 pubmed publisher
    ..This pattern implies reassortment and suggests that the novel form of hemagglutinin conferred a selective advantage. ..
  4. Liu J, Wennier S, Zhang L, McFadden G. M062 is a host range factor essential for myxoma virus pathogenesis and functions as an antagonist of host SAMD9 in human cells. J Virol. 2011;85:3270-82 pubmed publisher
    ..M062 also binds and antagonizes cellular SAMD9 in human cells, suggesting that SAMD9 is a novel innate antiviral factor against poxviruses...
  5. Pagán I, Holmes E, Simon Loriere E. Level of gene expression is a major determinant of protein evolution in the viral order Mononegavirales. J Virol. 2012;86:5253-63 pubmed publisher
  6. King C. Kaposi's sarcoma-associated herpesvirus kaposin B induces unique monophosphorylation of STAT3 at serine 727 and MK2-mediated inactivation of the STAT3 transcriptional repressor TRIM28. J Virol. 2013;87:8779-91 pubmed publisher
  7. Guo P, Schwartz C, Haak J, Zhao Z. Discovery of a new motion mechanism of biomotors similar to the earth revolving around the sun without rotation. Virology. 2013;446:133-43 pubmed publisher
    ..This revolution mechanism helps to solve the undesirable dsDNA supercoiling issue involved in rotation. ..
  8. Rao V, Eugenin E, Prasad V. Evaluating the Role of Viral Proteins in HIV-Mediated Neurotoxicity Using Primary Human Neuronal Cultures. Methods Mol Biol. 2016;1354:367-76 pubmed publisher
    ..To evaluate the toxicity of any viral isolate, viral protein, or host inflammatory protein, we describe a protocol to assess the neuronal apoptosis and synaptic compromise in primary cultures of human neurons and astrocytes. ..
  9. Chatterjee P, Coren J. Isolating large nested deletions in bacterial and P1 artificial chromosomes by in vivo P1 packaging of products of Cre-catalysed recombination between the endogenous and a transposed loxP site. Nucleic Acids Res. 1997;25:2205-12 pubmed
    ..These procedures should facilitate physical and functional mapping of genes and regulatory elements in these large plasmids...
  10. Banks J, Kealoha B, Linial M. An Mpsi-containing heterologous RNA, but not env mRNA, is efficiently packaged into avian retroviral particles. J Virol. 1999;73:8926-33 pubmed
    ..Finally, deletion of sequences from the 3' end of MPsi was found to reduce the packaging efficiency of heterologous RNAs. ..
  11. Dasika G, Letchworth G. Homologous and heterologous interference requires bovine herpesvirus-1 glycoprotein D at the cell surface during virus entry. J Gen Virol. 2000;81:1041-9 pubmed
    ..Thus BHV-1 gD is required at the cell surface at the time of infection in order to block BHV-1, HSV-1 and PRV infections, consistent with a common coreceptor for the three gDs. ..
  12. Lawson T, Sweep M, Schlax P, Bohnsack R, Haas A. Kinetic analysis of the conjugation of ubiquitin to picornavirus 3C proteases catalyzed by the mammalian ubiquitin-protein ligase E3alpha. J Biol Chem. 2001;276:39629-37 pubmed
  13. Hashimoto K, Joshi S, Koni P. A conditional null allele of the major histocompatibility IA-beta chain gene. Genesis. 2002;32:152-3 pubmed
  14. Means J, Muro I, Clem R. Silencing of the baculovirus Op-iap3 gene by RNA interference reveals that it is required for prevention of apoptosis during Orgyia pseudotsugata M nucleopolyhedrovirus infection of Ld652Y cells. J Virol. 2003;77:4481-8 pubmed
    ..These results show for the first time that Op-IAP3 is necessary to prevent apoptosis during OpMNPV infection. In addition, our results demonstrate that the RNAi technique can be an effective tool for studying baculovirus gene function. ..
  15. Crittenden M, Gough M, Chester J, Kottke T, Thompson J, Ruchatz A, et al. Pharmacologically regulated production of targeted retrovirus from T cells for systemic antitumor gene therapy. Cancer Res. 2003;63:3173-80 pubmed
    ..We hypothesize that this enhanced targeting to tumor sites is responsible for the efficiency of T cell-mediated retroviral gene transfer and that this principle can be used to enhance systemic therapies using immune-cell carriers. ..
  16. Oomens A, Wertz G. The baculovirus GP64 protein mediates highly stable infectivity of a human respiratory syncytial virus lacking its homologous transmembrane glycoproteins. J Virol. 2004;78:124-35 pubmed
    ..These results demonstrate the potential of GP64 for both practical applications requiring stable pseudotypes in mammalian systems and for studies of viral glycoprotein requirements in assembly and pathogenesis. ..
  17. Lednicky J, Meehan T, Kinsel M, Dubach J, Hungerford L, Sarich N, et al. Effective primary isolation of wild-type canine distemper virus in MDCK, MV1 Lu and Vero cells without nucleotide sequence changes within the entire haemagglutinin protein gene and in subgenomic sections of the fusion and phospho protein genes. J Virol Methods. 2004;118:147-57 pubmed
    ..Different viral phenotypes and genotypes were detected. The conservation of H gene sequences in primary CDV isolates suggests that MDCK, MV1 Lu, and Vero cells express proper receptors for wild-type CDV. ..
  18. Polcicova K, Biswas P, Banerjee K, Wisner T, Rouse B, Johnson D. Herpes keratitis in the absence of anterograde transport of virus from sensory ganglia to the cornea. Proc Natl Acad Sci U S A. 2005;102:11462-7 pubmed
    ..Nevertheless, US9- HSV caused keratitis. Therefore, herpes keratitis can occur without anterograde transport from ganglia to the cornea, probably mediated by virus persistent in the cornea. ..
  19. Arnold H, Sears R. Protein phosphatase 2A regulatory subunit B56alpha associates with c-myc and negatively regulates c-myc accumulation. Mol Cell Biol. 2006;26:2832-44 pubmed
    ..These results uncover a new protein involved in regulating c-Myc expression and reveal a critical interconnection between a potent oncoprotein, c-Myc, and a well-documented tumor suppressor, PP2A. ..
  20. Borisevich V, Seregin A, Nistler R, Mutabazi D, Yamshchikov V. Biological properties of chimeric West Nile viruses. Virology. 2006;349:371-81 pubmed publisher
    ..Chimeric viruses carrying the NY99 structural proteins were attenuated in neuroinvasiveness and demonstrated an immunogenicity superior to W956...
  21. Turchan Cholewo J, Liu Y, Gartner S, Reid R, Jie C, Peng X, et al. Increased vulnerability of ApoE4 neurons to HIV proteins and opiates: protection by diosgenin and L-deprenyl. Neurobiol Dis. 2006;23:109-19 pubmed
    ..In conclusion, opiate abusers with HIV infection and the ApoE4 allele may be at increased risk of developing dementia. L-deprenyl and a plant estrogen, diosgenin, may have therapeutic potential in this population. ..
  22. Gong P, Martin C. Mechanism of instability in abortive cycling by T7 RNA polymerase. J Biol Chem. 2006;281:23533-44 pubmed publisher
  23. Kroemer J, Webb B. Divergences in protein activity and cellular localization within the Campoletis sonorensis Ichnovirus Vankyrin family. J Virol. 2006;80:12219-28 pubmed
    ..Insect cells infected with these viruses exhibited enhanced longevity compared to those infected with viruses expressing other vankyrins. Together, these data suggest that vankyrin proteins in CsIV have divergent physiological functions...
  24. Han Z, Marendy E, Wang Y, Yuan J, Sample J, Swaminathan S. Multiple roles of Epstein-Barr virus SM protein in lytic replication. J Virol. 2007;81:4058-69 pubmed
    ..Thus, SM plays a role in multiple steps of lytic cycle EBV gene expression and that it is transcript-specific in both activation and repression functions. ..
  25. Goenka S, Weaver R. The p26 gene of the Autographa californica nucleopolyhedrovirus: timing of transcription, and cellular localization and dimerization of product. Virus Res. 2008;131:136-44 pubmed
    ..A yeast two-hybrid assay detected p26 in association only with other p26 molecules. Biochemical analysis showed that p26 forms dimers under physiological conditions. ..
  26. Chowda Reddy R, Achenjang F, Felton C, Etarock M, Anangfac M, Nugent P, et al. Role of a geminivirus AV2 protein putative protein kinase C motif on subcellular localization and pathogenicity. Virus Res. 2008;135:115-24 pubmed publisher
    ..We therefore suggest the use of the AV2 putative PKC mutants to generate transgenic plants...
  27. Boyoglu S, Vig K, Pillai S, Rangari V, Dennis V, Khazi F, et al. Enhanced delivery and expression of a nanoencapsulated DNA vaccine vector for respiratory syncytial virus. Nanomedicine. 2009;5:463-72 pubmed publisher
  28. Lee S, Vigliotti V, Pappu S. Molecular tests for human papillomavirus (HPV), Chlamydia trachomatis and Neisseria gonorrhoeae in liquid-based cytology specimen. BMC Womens Health. 2009;9:8 pubmed publisher
    ..However, even a highly specific test for high-risk HPV genotyping may have unacceptably low positive predictive values for precancer lesion in populations with a low cervical cancer prevalence rate. ..
  29. Endres M, Gregory B, Gao Z, Foreman A, Mlotshwa S, Ge X, et al. Two plant viral suppressors of silencing require the ethylene-inducible host transcription factor RAV2 to block RNA silencing. PLoS Pathog. 2010;6:e1000729 pubmed publisher
  30. Daugherty M, Malik H. Rules of engagement: molecular insights from host-virus arms races. Annu Rev Genet. 2012;46:677-700 pubmed publisher
  31. Haralambieva I, Oberg A, Ovsyannikova I, Kennedy R, Grill D, Middha S, et al. Genome-wide characterization of transcriptional patterns in high and low antibody responders to rubella vaccination. PLoS ONE. 2013;8:e62149 pubmed publisher
    ..Such information may provide new scientific insights into vaccine-induced immunity useful in rational vaccine development and immune response monitoring...
  32. McClure L, Sullivan C. Kaposi's sarcoma herpes virus taps into a host microRNA regulatory network. Cell Host Microbe. 2008;3:1-3 pubmed publisher
    ..Two new papers provide strong evidence that a KSHV-encoded microRNA and mir-155 share a common set of mRNA targets and binding sites, implying a possible link between viral- and non-viral-mediated tumorigenesis. ..
  33. Peng C, Haller S, Rahman M, McFadden G, Rothenburg S. Myxoma virus M156 is a specific inhibitor of rabbit PKR but contains a loss-of-function mutation in Australian virus isolates. Proc Natl Acad Sci U S A. 2016;113:3855-60 pubmed publisher
    ..The species-specific inhibition of rabbit PKR by M156 and the M156 loss-of-function in Australian MYXV field isolates might thus contribute to the species specificity of MYXV and to the attenuation in the field, respectively. ..
  34. Cao S, Dhungel P, Yang Z. Going against the Tide: Selective Cellular Protein Synthesis during Virally Induced Host Shutoff. J Virol. 2017;91: pubmed publisher
    ..Identifying mechanisms that drive selective protein synthesis should facilitate understanding both viral replication and fundamental cell biology. ..
  35. Tilakaratne N, Hardin S, Weaver R. Nucleotide sequence and transcript mapping of the HindIII F region of the Autographa californica nuclear polyhedrosis virus genome. J Gen Virol. 1991;72 ( Pt 2):285-91 pubmed
    ..However, the conserved late gene promoter/cap site sequence (ATAAG) is present 23 nt upstream of the start of ORF-3. ..
  36. Grdzelishvili V, Smallwood S, Tower D, Hall R, Hunt D, Moyer S. Identification of a new region in the vesicular stomatitis virus L polymerase protein which is essential for mRNA cap methylation. Virology. 2006;350:394-405 pubmed
    ..J. Virol. 79, 13373-13384], a new region between L amino acids 1450-1481 was identified which is critical for mRNA cap methylation. ..
  37. Ladman B, Loupos A, Gelb J. Infectious bronchitis virus S1 gene sequence comparison is a better predictor of challenge of immunity in chickens than serotyping by virus neutralization. Avian Pathol. 2006;35:127-33 pubmed
    ..The findings indicated partial S1 sequence identity values were more strongly correlated with protective relatedness values and than antigenic relatedness values. ..
  38. Hwang Y, Leong O, Chen W, Yates M. Comparison of a reporter assay and immunomagnetic separation real-time reverse transcription-PCR for the detection of enteroviruses in seeded environmental water samples. Appl Environ Microbiol. 2007;73:2338-40 pubmed
    ..Both new procedures detected infective viruses in environmental samples at the same level as the plaque assay. ..
  39. Shkilnyj P, Koudelka G. Effect of salt shock on stability of lambdaimm434 lysogens. J Bacteriol. 2007;189:3115-23 pubmed
    ..Regardless of the precise mechanism, our findings demonstrate that salt stress can regulate the phage lysis-lysogeny switch. ..
  40. Bu W, Carroll K, Palmeri D, Lukac D. Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 ORF50/Rta lytic switch protein functions as a tetramer. J Virol. 2007;81:5788-806 pubmed
    ..We concluded that the proline content, but not the leucine content, of the LR is critical for determining the oligomeric state of Rta. ..
  41. Verchot Lubicz J, Ye C, Bamunusinghe D. Molecular biology of potexviruses: recent advances. J Gen Virol. 2007;88:1643-55 pubmed
    ..PVX is also a tool for studying Avr-R gene interactions and gene silencing in plants. The PVX CP is the elicitor for the Rx gene. Recent reports of the PVX CP reveal how CP interacts with the Rx gene product. ..
  42. Nakahara T, Lambert P. Induction of promyelocytic leukemia (PML) oncogenic domains (PODs) by papillomavirus. Virology. 2007;366:316-29 pubmed
    ..Neither the E2-dependent transcription nor viral DNA replication was reliant upon the presence of PML. Implications of these findings in terms of HPV's interaction with its host are discussed. ..
  43. Yang S, Hruby D. Vaccinia virus A12L protein and its AG/A proteolysis play an important role in viral morphogenic transition. Virol J. 2007;4:73 pubmed
    ..Thus, we concluded that the not only A12L protein but also its cleavage processing plays an essential role in virus morphogenic transition. ..
  44. Chang P, Li M. Kaposi's sarcoma-associated herpesvirus K-cyclin interacts with Cdk9 and stimulates Cdk9-mediated phosphorylation of p53 tumor suppressor. J Virol. 2008;82:278-90 pubmed publisher
    ..Together, our findings for the first time demonstrated the interaction of K-cyclin and Cdk9 and revealed a new molecular link between K-cyclin and p53...
  45. Condit R. Vaccinia, Inc.--probing the functional substructure of poxviral replication factories. Cell Host Microbe. 2007;2:205-7 pubmed
    ..These factories thus comprise a highly structured virus organelle that isolates and coordinates late viral replication events, facilitating competition for cellular resources...
  46. Neznanov N, Dragunsky E, Chumakov K, Neznanova L, Wek R, Gudkov A, et al. Different effect of proteasome inhibition on vesicular stomatitis virus and poliovirus replication. PLoS ONE. 2008;3:e1887 pubmed publisher
    ..To our knowledge, this is the first study that connects the effect of stress induced by proteasome inhibition with the efficiency of viral infection. ..
  47. Verma D, Swaminathan S. Epstein-Barr virus SM protein functions as an alternative splicing factor. J Virol. 2008;82:7180-8 pubmed publisher
    ..These results suggest that viruses may regulate cellular gene expression at the level of alternative mRNA splicing in order to facilitate virus replication or persistence in vivo. ..
  48. Galloway S, Wertz G. S-adenosyl homocysteine-induced hyperpolyadenylation of vesicular stomatitis virus mRNA requires the methyltransferase activity of L protein. J Virol. 2008;82:12280-90 pubmed publisher
    ..Further, the data presented here show that the wild-type L protein hyperpolyadenylates a percentage of VSV mRNAs in infected cells as well as in vitro. ..
  49. Merchant A, Smielewska M, Patel N, Akunowicz J, Saria E, Delaney J, et al. Somatic mutations in SQSTM1 detected in affected tissues from patients with sporadic Paget's disease of bone. J Bone Miner Res. 2009;24:484-94 pubmed publisher
    ..The discovery of somatically acquired mutations in both the diseased bone and tumor samples suggests a paradigm shift in our understanding of this disease. ..
  50. Child S, Geballe A. Binding and relocalization of protein kinase R by murine cytomegalovirus. J Virol. 2009;83:1790-9 pubmed publisher
    ..These results suggest a model in which the pm142-pm143 multimer interacts with PKR and causes its sequestration in cellular compartments where it is unable to shut off translation and repress viral replication. ..
  51. Livingston C, Ifrim M, Cowan A, Weller S. Virus-Induced Chaperone-Enriched (VICE) domains function as nuclear protein quality control centers during HSV-1 infection. PLoS Pathog. 2009;5:e1000619 pubmed publisher
    ..The experiments presented in this paper suggest that VICE domains are nuclear protein quality control centers that are modified by HSV-1 to promote productive infection. ..
  52. Gilmore J, Bieber Urbauer R, Minakhin L, Akoyev V, Zolkiewski M, Severinov K, et al. Determinants of affinity and activity of the anti-sigma factor AsiA. Biochemistry. 2010;49:6143-54 pubmed publisher
  53. Wozniak A, Griffin S, Rowlands D, Harris M, Yi M, Lemon S, et al. Intracellular proton conductance of the hepatitis C virus p7 protein and its contribution to infectious virus production. PLoS Pathog. 2010;6:e1001087 pubmed publisher
    ..This loss of acidification is required for productive HCV infection, possibly through protecting nascent virus particles during an as yet uncharacterized maturation process. ..
  54. Laney A, Keller K, Martin R, Tzanetakis I. A discovery 70 years in the making: characterization of the Rose rosette virus. J Gen Virol. 2011;92:1727-32 pubmed publisher
    ..Diversity studies using two virus proteins, p3 and p4, demonstrated that the virus has low diversity between isolates as they share nucleotide identities ranging from 97 to 99%. ..
  55. Sharma M, Sasvari Z, Nagy P. Inhibition of phospholipid biosynthesis decreases the activity of the tombusvirus replicase and alters the subcellular localization of replication proteins. Virology. 2011;415:141-52 pubmed publisher
    ..These data are consistent with the important role of phospholipids in RNA virus replication...
  56. Ogino T, Banerjee A. An unconventional pathway of mRNA cap formation by vesiculoviruses. Virus Res. 2011;162:100-9 pubmed publisher
    ..This article summarizes the historical and current research that led to the discovery of the novel vesiculoviral mRNA capping reaction. ..
  57. Patel D, Schultz L, Umland T. Influenza A polymerase subunit PB2 possesses overlapping binding sites for polymerase subunit PB1 and human MAVS proteins. Virus Res. 2013;172:75-80 pubmed publisher
    ..Additionally, the results of this study suggest a new strategy to develop influenza A therapeutics by simultaneously blocking PB2-MAVS and PB2-PB1 protein-protein interactions and their resulting activities. ..
  58. Qiao J, Mindich L. The template specificity of bacteriophage Phi6 RNA polymerase. J Virol. 2013;87:10190-4 pubmed publisher
    ..Adding YajQ to purified polymerase does not change its transcription specificity. ..
  59. Singh D, Boeras I, Singh G, Boris Lawrie K. Isolation of Cognate Cellular and Viral Ribonucleoprotein Complexes of HIV-1 RNA Applicable to Proteomic Discovery and Molecular Investigations. Methods Mol Biol. 2016;1354:133-46 pubmed publisher
    ..Here, we describe RNA affinity chromatography of the 5' untranslated region of HIV-1, obtaining mixtures of high-affinity RNA binding proteins suitable for mass spectrometry and proteome identification. ..
  60. Horikami S, Smallwood S, Moyer S. The Sendai virus V protein interacts with the NP protein to regulate viral genome RNA replication. Virology. 1996;222:383-90 pubmed publisher
    ..We propose that the specific inhibition of genome replication by V and W proteins occurs through interference with either the formation or the use of the NPo-P encapsidation substrate...
  61. Yu W, Murfett J, Schoelz J. Differential induction of symptoms in Arabidopsis by P6 of Cauliflower mosaic virus. Mol Plant Microbe Interact. 2003;16:35-42 pubmed
    ..That comparative analysis of TAV function, coupled with the characterization of the D4-2 transgenic line in the present paper, indicates that the TAV function of P6 may play only a minor role in the development of chlorotic symptoms...
  62. Cevik B, Holmes D, Vrotsos E, Feller J, Smallwood S, Moyer S. The phosphoprotein (P) and L binding sites reside in the N-terminus of the L subunit of the measles virus RNA polymerase. Virology. 2004;327:297-306 pubmed
    ..Full-length L mutants that did not bind P were also inactive in viral RNA synthesis, showing a direct correlation between P-L complex formation and activity. ..
  63. Nelson S, Benkovic S. The T4 phage UvsW protein contains both DNA unwinding and strand annealing activities. J Biol Chem. 2007;282:407-16 pubmed
    ..The dual activities of UvsW are well suited for the DNA repair pathways described for leading strand lesion bypass and synthesis-dependent strand annealing. ..
  64. Majji S, LaPatra S, Long S, Sample R, Bryan L, Sinning A, et al. Rana catesbeiana virus Z (RCV-Z): a novel pathogenic ranavirus. Dis Aquat Organ. 2006;73:1-11 pubmed
    ..Collectively, these results suggest that RCV-Z may represent a novel species of ranavirus capable of infecting frogs and that possession of a viral eIF-2alpha homolog (vIF-2alpha) correlates with enhanced virulence...
  65. Oliver S, Zerboni L, Sommer M, Rajamani J, Arvin A. Development of recombinant varicella-zoster viruses expressing luciferase fusion proteins for live in vivo imaging in human skin and dorsal root ganglia xenografts. J Virol Methods. 2008;154:182-93 pubmed publisher
    ..Thus, IE63-luciferase fusion proteins were effective for investigating VZV infection and antiviral activity in human xenografts. ..
  66. Nash K, Chen W, Salganik M, Muzyczka N. Identification of cellular proteins that interact with the adeno-associated virus rep protein. J Virol. 2009;83:454-69 pubmed publisher
    ..Our study suggests that the interaction of AAV with cellular proteins is much more complex than previously suspected and provides a resource for further studies of the AAV life cycle. ..
  67. Vomaske J, Nelson J, Streblow D. Human Cytomegalovirus US28: a functionally selective chemokine binding receptor. Infect Disord Drug Targets. 2009;9:548-56 pubmed
    ..Understanding the structure/function relationships between US28, its ligands and intracellular signaling molecules will provide essential clues for effective pharmacological targeting of this multifunctional chemokine receptor. ..
  68. Pager C, Schütz S, Abraham T, Luo G, Sarnow P. Modulation of hepatitis C virus RNA abundance and virus release by dispersion of processing bodies and enrichment of stress granules. Virology. 2013;435:472-84 pubmed publisher
    ..These data argue that HCV subverts P-body and stress granule components to aid in viral gene expression at particular sites in the cytoplasm. ..
  69. Binkley P, Cooke G, Lesinski A, Taylor M, Chen M, Laskowski B, et al. Evidence for the role of Epstein Barr Virus infections in the pathogenesis of acute coronary events. PLoS ONE. 2013;8:e54008 pubmed publisher
    ..They further support the putative role of viral infections in the pathogenesis of atherosclerosis and coronary artery events...
  70. Kratchmarov R, Kramer T, Greco T, Taylor M, Ch ng T, Cristea I, et al. Glycoproteins gE and gI are required for efficient KIF1A-dependent anterograde axonal transport of alphaherpesvirus particles in neurons. J Virol. 2013;87:9431-40 pubmed publisher
    ..We propose that gE/gI are required for efficient KIF1A-mediated anterograde transport of viral particles because they indirectly facilitate or stabilize the interaction between Us9 and KIF1A. ..
  71. Nogales A, Baker S, Domm W, Martínez Sobrido L. Development and applications of single-cycle infectious influenza A virus (sciIAV). Virus Res. 2016;216:26-40 pubmed publisher
    ..Here, we review the recent burst in sciIAV generation and summarize the applications and findings on this important human pathogen using biocontained viral mimics. ..
  72. Wei Y, Xu G, Zhang G, Wen C, Anwar F, Wang S, et al. Antigenic evolution of H9N2 chicken influenza viruses isolated in China during 2009-2013 and selection of a candidate vaccine strain with broad cross-reactivity. Vet Microbiol. 2016;182:1-7 pubmed publisher
    ..Systematic surveillance and timely updating of vaccine strains are important for viral prevention and control in the future. ..
  73. Huang R, Panin M, Romito R, Huang Y. Inhibition of replication of human respiratory syncytial virus by 6-diazo-5-oxo-L-norleucine. Antiviral Res. 1994;25:269-79 pubmed
    ..Furthermore, immunofluorescent staining showed that drug treated cells expressed both F and N proteins and that F was inserted into the membrane as the native F protein. ..
  74. Zehfus M. Improved calculations of compactness and a reevaluation of continuous compact units. Proteins. 1993;16:293-300 pubmed
    ..This method is robust, and yields similar units even when applied to coordinates of protein crystals grown under different experimental conditions. ..
  75. Wright C, Means J, Penabaz T, Clem R. The baculovirus anti-apoptotic protein Op-IAP does not inhibit Drosophila caspases or apoptosis in Drosophila S2 cells and instead sensitizes S2 cells to virus-induced apoptosis. Virology. 2005;335:61-71 pubmed
    ..The observation that Op-IAP cannot inhibit these insect caspases suggests that it functions by a mechanism that does not involve direct caspase inhibition. ..
  76. Plaza J, Nuovo G. Histologic and molecular correlates of fatal measles infection in children. Diagn Mol Pathol. 2005;14:97-102 pubmed
  77. Mertz J, Simper M, Lozano M, Payne S, Dudley J. Mouse mammary tumor virus encodes a self-regulatory RNA export protein and is a complex retrovirus. J Virol. 2005;79:14737-47 pubmed
    ..Manipulation of the MMTV genome may provide mouse models for human retroviral diseases, such as AIDS...
  78. Collins A, Nakahara T, Do A, Lambert P. Interactions with pocket proteins contribute to the role of human papillomavirus type 16 E7 in the papillomavirus life cycle. J Virol. 2005;79:14769-80 pubmed
    ..These data indicate that different hallmarks of the productive stage of the HPV16 life cycle rely upon different sets of requirements for E7. ..
  79. Ju H, Brown J, Ye C, Verchot Lubicz J. Mutations in the central domain of potato virus X TGBp2 eliminate granular vesicles and virus cell-to-cell trafficking. J Virol. 2007;81:1899-911 pubmed
    ..These results identify a novel element in the PVX TGBp2 protein which determines vesicle morphology. In addition, the data indicate that vesicles of the granular type induced by TGBp2 are necessary for PVX plasmodesmata transport. ..
  80. Kong B, Foster L, Foster D. Establishment of an immortal turkey turbinate cell line suitable for avian metapneumovirus propagation. Virus Res. 2007;127:106-15 pubmed
    ..The non-tumorigenic, reverse transcriptase negative TT-1 cell line can serve as an excellent homologous cellular substrate for virus propagation. ..
  81. Broxson C, Beckett J, Tornaletti S. Transcription arrest by a G quadruplex forming-trinucleotide repeat sequence from the human c-myb gene. Biochemistry. 2011;50:4162-72 pubmed publisher
    ..Our results support a mechanism of transcription-coupled DNA repair initiated by arrest of transcription at G4 structures. ..
  82. Ogram S, Flanegan J. Non-template functions of viral RNA in picornavirus replication. Curr Opin Virol. 2011;1:339-46 pubmed publisher
    ..Co-ordinating these long-range interactions is important in regulating each step in the replication cycle. ..
  83. Beyer I, Cao H, Persson J, Song H, Richter M, Feng Q, et al. Coadministration of epithelial junction opener JO-1 improves the efficacy and safety of chemotherapeutic drugs. Clin Cancer Res. 2012;18:3340-51 pubmed publisher
    ..Our preliminary data suggest that JO-1 cotherapy has the potential to improve the therapeutic outcome of cancer chemotherapy. ..
  84. Jia Y, Patel S. Kinetic mechanism of GTP binding and RNA synthesis during transcription initiation by bacteriophage T7 RNA polymerase. J Biol Chem. 1997;272:30147-53 pubmed
  85. You S, Falgout B, Markoff L, Padmanabhan R. In vitro RNA synthesis from exogenous dengue viral RNA templates requires long range interactions between 5'- and 3'-terminal regions that influence RNA structure. J Biol Chem. 2001;276:15581-91 pubmed publisher
    ..RNA synthesis at the 3'-UTR, however, requires long range interactions involving the 5'-UTR, CYC motifs, and the 3'-stem-loop region that includes the tertiary pseudoknot structure...
  86. Johansen L, Carrington J. Silencing on the spot. Induction and suppression of RNA silencing in the Agrobacterium-mediated transient expression system. Plant Physiol. 2001;126:930-8 pubmed
    ..They also indicate that RNA silencing may be a significant limitation to expression of genes in the Agrobacterium-mediated transient assay but that this limitation can be overcome by using RNA silencing suppressors. ..
  87. Kapczynski D, Sellers H, Simmons V, Schultz Cherry S. Sequence analysis of the S3 gene from a turkey reovirus. Virus Genes. 2002;25:95-100 pubmed
  88. Amaya K, Asgari S, Jung R, Hongskula M, Beckage N. Parasitization of Manduca sexta larvae by the parasitoid wasp Cotesia congregata induces an impaired host immune response. J Insect Physiol. 2005;51:505-12 pubmed
    ..A CrV1-homolog gene product was localized in host hemocytes using polyclonal CrV1 antibodies, suggesting that CrV1-like gene products of C. congregata's bracovirus are responsible for the impaired immune response of the host. ..
  89. Nagy P, Pogany J. Yeast as a model host to dissect functions of viral and host factors in tombusvirus replication. Virology. 2006;344:211-20 pubmed
    ..The knowledge obtained will likely stimulate development of new antiviral methods as well as other approaches that could make tombusviruses useful tools in biotechnological applications...
  90. Turner P, Moyer R. The cowpox virus fusion regulator proteins SPI-3 and hemagglutinin interact in infected and uninfected cells. Virology. 2006;347:88-99 pubmed
    ..The HA-binding domain in SPI-3 resided in the C-terminal 229 residues, and did not include helix D, which mediates cofactor interaction in many other serpins...
  91. Michael B, Nair A, Datta A, Hiraragi H, Ratner L, Lairmore M. Histone acetyltransferase (HAT) activity of p300 modulates human T lymphotropic virus type 1 p30II-mediated repression of LTR transcriptional activity. Virology. 2006;354:225-39 pubmed
    ..Collectively, our data indicate that HTLV-1 p30II modulates viral gene expression in a cooperative manner with p300-mediated acetylation. ..
  92. Cresawn S, Prins C, Latner D, Condit R. Mapping and phenotypic analysis of spontaneous isatin-beta-thiosemicarbazone resistant mutants of vaccinia virus. Virology. 2007;363:319-32 pubmed
    ..The results implicate the largest subunit of the RNA polymerase (rpo147) in the control of elongation, and suggest that there exist additional gene products which mediate intermediate and late transcription elongation in vaccinia virus. ..