Genomes and Genes
Experts and Doctors on tyrosine in Canada
- Richard M, Thibault N, Veilleux P, Gareau Pagé G, Beaulieu A. Granulocyte macrophage-colony stimulating factor reduces the affinity of SHP-2 for the ITIM of CLECSF6 in neutrophils: a new mechanism of action for SHP-2. Mol Immunol. 2006;43:1716-21 pubmed..Therefore, upon a treatment with GM-CSF, SHP-2 could move from a CLECSF6 associated signalosome with a repressor function to a GM-CSF receptor associated signalosome with an activator function. ..
- Lee J, Johnson J, Ding Z, Paetzel M, Cornell R. Crystal structure of a mammalian CTP: phosphocholine cytidylyltransferase catalytic domain reveals novel active site residues within a highly conserved nucleotidyltransferase fold. J Biol Chem. 2009;284:33535-48 pubmed publisher..Comparison of the CCT236 structure with those of other nucleotidyltransferases provides evidence for substrate-induced active site loop movements and a disorder-to-order transition of a loop element in the catalytic mechanism. ..
- Al Shami A, Naccache P. Granulocyte-macrophage colony-stimulating factor-activated signaling pathways in human neutrophils. Involvement of Jak2 in the stimulation of phosphatidylinositol 3-kinase. J Biol Chem. 1999;274:5333-8 pubmed..These results suggest that stimulation of the activity of PI3-kinase induced by GM-CSF is mediated by Jak2 and that the association between Jak2 and p85 depends on an adaptor protein yet to be identified. ..
- Lambert A, Barabé F, Gilbert C, Tremblay M. DCIR-mediated enhancement of HIV-1 infection requires the ITIM-associated signal transduction pathway. Blood. 2011;117:6589-99 pubmed publisher..Our data suggest for the first time an involvement of ITIM domain in HIV-1-mediated signaling events and a relationship between phosphorylation events and DCIR function with respect to HIV-1 biology. ..
- Lamalice L, Houle F, Huot J. Phosphorylation of Tyr1214 within VEGFR-2 triggers the recruitment of Nck and activation of Fyn leading to SAPK2/p38 activation and endothelial cell migration in response to VEGF. J Biol Chem. 2006;281:34009-20 pubmed..In turn, this triggers the activation of the SAPK2/p38 MAP kinase module, and promotes stress fiber formation and endothelial cell migration. ..
- Khambati H, Moraes T, Singh J, Shouldice S, Yu R, Schryvers A. The role of vicinal tyrosine residues in the function of Haemophilus influenzae ferric-binding protein A. Biochem J. 2010;432:57-64 pubmed publisher..Collectively, these results demonstrate that the presence of a twin-tyrosine motif common to many periplasmic iron-binding proteins is critical for initially capturing the ferric ion released by the outer-membrane receptor complex. ..
- Paramithiotis E, Pinard M, Lawton T, LaBoissiere S, Leathers V, Zou W, et al. A prion protein epitope selective for the pathologically misfolded conformation. Nat Med. 2003;9:893-9 pubmed..Conformation-selective exposure of Tyr-Tyr-Arg provides a probe for the distribution and structure of pathologically misfolded prion protein, and may lead to new diagnostics and therapeutics for prion diseases. ..
- Laprise P, Viel A, Rivard N. Human homolog of disc-large is required for adherens junction assembly and differentiation of human intestinal epithelial cells. J Biol Chem. 2004;279:10157-66 pubmed..We conclude that hDlg may be a determinant in E-cadherin-mediated adhesion and signaling in mammalian epithelial cells. ..
- Beaudoin J, Mercier A, Langlois R, Labbe S. The Schizosaccharomyces pombe Cuf1 is composed of functional modules from two distinct classes of copper metalloregulatory transcription factors. J Biol Chem. 2003;278:14565-77 pubmed..pombe Cuf1 1-61, and the nature of the amino acids located downstream of this amino-terminal conserved region may be crucial in dictating the type of regulatory response required to establish and maintain copper homeostasis. ..
- Duchesne C, Charland S, Asselin C, Nahmias C, Rivard N. Negative regulation of beta-catenin signaling by tyrosine phosphatase SHP-1 in intestinal epithelial cells. J Biol Chem. 2003;278:14274-83 pubmed..Taken together, our results indicate that SHP-1 may be involved in the regulation of beta-catenin transcriptional function and in the negative control of intestinal epithelial cell proliferation. ..
- Lachance G, Levasseur S, Naccache P. Chemotactic factor-induced recruitment and activation of Tec family kinases in human neutrophils. Implication of phosphatidynositol 3-kinases. J Biol Chem. 2002;277:21537-41 pubmed..They also suggest that one of the links between G protein-coupled receptors and tyrosine kinases depends on the activation of phosphatidylinositol 3-kinase and the generation of phosphatidylinositol 3,4,5-trisphosphate. ..
- Freywald A, Sharfe N, Roifman C. The kinase-null EphB6 receptor undergoes transphosphorylation in a complex with EphB1. J Biol Chem. 2002;277:3823-8 pubmed..Our findings demonstrate that EphB6 is an actively signaling receptor that undergoes transphosphorylation upon ligand binding and that can initiate specific cytoplasmic signaling events. ..
- Némorin J, LaPorte P, Bérubé G, Duplay P. p62dok negatively regulates CD2 signaling in Jurkat cells. J Immunol. 2001;166:4408-15 pubmed..These results suggest that p62(dok) plays a negative role at multiple steps in the CD2 signaling pathway. We propose that p62(dok) may represent an important negative regulator in the modulation of the response mediated by the TCR. ..
- Li S, Gish G, Yang D, Coffey A, Forman Kay J, Ernberg I, et al. Novel mode of ligand binding by the SH2 domain of the human XLP disease gene product SAP/SH2D1A. Curr Biol. 1999;9:1355-62 pubmed..These data point to the flexibility of modular protein-interaction domains. ..
- Liu S, McGlade C. Gads is a novel SH2 and SH3 domain-containing adaptor protein that binds to tyrosine-phosphorylated Shc. Oncogene. 1998;17:3073-82 pubmed
- Kozlowski M, Larose L, Lee F, Le D, Rottapel R, Siminovitch K. SHP-1 binds and negatively modulates the c-Kit receptor by interaction with tyrosine 569 in the c-Kit juxtamembrane domain. Mol Cell Biol. 1998;18:2089-99 pubmed
- Bachmaier K, Neu N, Pummerer C, Duncan G, Mak T, Matsuyama T, et al. iNOS expression and nitrotyrosine formation in the myocardium in response to inflammation is controlled by the interferon regulatory transcription factor 1. Circulation. 1997;96:585-91 pubmed..Because autoimmune myocarditis can develop in animals lacking IRF-1, these mice will be useful to elucidate the link between iNOS expression in inflammatory heart disease and the development of dilated cardiomyopathy and heart failure. ..
- Briand G, Barbeau B, Tremblay M. Binding of HIV-1 to its receptor induces tyrosine phosphorylation of several CD4-associated proteins, including the phosphatidylinositol 3-kinase. Virology. 1997;228:171-9 pubmed..The four CD4-associated molecules described in this report are most likely implicated in virus-induced CD4-linked signaling events. ..
- Le H, Ponniah S, Pallen C. Insulin signaling and glucose homeostasis in mice lacking protein tyrosine phosphatase alpha. Biochem Biophys Res Commun. 2004;314:321-9 pubmed..Our data indicate that PTPalpha is not a negative regulator of insulin signaling and does not perform an essential role in mediating the physiological action of insulin. ..
- Ridyard M, Robbins S. Fibroblast growth factor-2-induced signaling through lipid raft-associated fibroblast growth factor receptor substrate 2 (FRS2). J Biol Chem. 2003;278:13803-9 pubmed..This work suggests that compartmentalized signaling within lipid rafts may provide a level of specificity for growth factor signaling. ..
- Okkenhaug K, Wu L, Garza K, La Rose J, Khoo W, Odermatt B, et al. A point mutation in CD28 distinguishes proliferative signals from survival signals. Nat Immunol. 2001;2:325-32 pubmed..Thus, we describe a single point mutation within the CD28 cytoplasmic domain that uncouples signals required for proliferation and survival. ..