Experts and Doctors on tumor virus infections in Denmark
Topic: tumor virus infections
Beer C, Pedersen L. Matrix fibronectin binds gammaretrovirus and assists in entry: new light on viral infections. J Virol. 2007;81:8247-57 pubmed
..We suggest that binding to the cellular fibronectin matrix provides a new mechanism by which viruses can enter cells. ..
Mogensen T, Paludan S. Virus-cell interactions: impact on cytokine production, immune evasion and tumor growth. Eur Cytokine Netw. 2001;12:382-90 pubmed
..This review describes how virus infections affect cellular signal transduction and the mechanisms through which certain viruses modulate this response to dampen the immune response or prevent cell death. ..
Aagaard L, Mikkelsen J, Warming S, Duch M, Pedersen F. Fv1-like restriction of N-tropic replication-competent murine leukaemia viruses in mCAT-1-expressing human cells. J Gen Virol. 2002;83:439-42 pubmed
Nielsen A, Sørensen A, Schmidt J, Pedersen F. Analysis of wild-type and mutant SL3-3 murine leukemia virus insertions in the c-myc promoter during lymphomagenesis reveals target site hot spots, virus-dependent patterns, and frequent error-prone gap repair. J Virol. 2005;79:67-78 pubmed
..Unexpectedly, about 12% of the sequenced insertions were associated with point mutations in the direct repeat flanking the provirus. Based on these results, we propose a model for error-prone gap repair of host-provirus junctions...
Sørensen K, Kunder S, Quintanilla Martinez L, Sørensen J, Schmidt J, Pedersen F. Enhancer mutations of Akv murine leukemia virus inhibit the induction of mature B-cell lymphomas and shift disease specificity towards the more differentiated plasma cell stage. Virology. 2007;362:179-91 pubmed
..Our results indicate that enhancer mutations weaken the ability of Akv to induce mature B-cell lymphomas prior to the plasma cell stage, whereas development of plasma cell proliferations is less dependent of viral enhancer strength...
Sørensen A, Lund A, Kunder S, Quintanilla Martinez L, Schmidt J, Wang B, et al
. Impairment of alternative splice sites defining a novel gammaretroviral exon within gag modifies the oncogenic properties of Akv murine leukemia virus. Retrovirology. 2007;4:46 pubmed
..In the present study we investigate the splice pattern as well as the possible effects of mutating the alternative splice sites on the oncogenic properties of the B-lymphomagenic Akv murine leukemia virus...
Grum Schwensen B, Klingelhofer J, Grigorian M, Almholt K, Nielsen B, Lukanidin E, et al
. Lung metastasis fails in MMTV-PyMT oncomice lacking S100A4 due to a T-cell deficiency in primary tumors. Cancer Res. 2010;70:936-47 pubmed publisher
..Similar processes could occur in the premetastatic lungs, facilitating generation of inflammatory milieu favorable for metastasis formation. ..
Kjær S, Frederiksen K, Munk C, Iftner T. Long-term absolute risk of cervical intraepithelial neoplasia grade 3 or worse following human papillomavirus infection: role of persistence. J Natl Cancer Inst. 2010;102:1478-88 pubmed publisher
..The results indicate the potential value of genotyping in cervical cancer screening. Given that HPV DNA-negative women retained their low risk of CIN3 or worse for many years, frequent screening of these women may be unnecessary. ..
Sørensen A, Lund A, Ethelberg S, Copeland N, Jenkins N, Pedersen F. Sint1, a common integration site in SL3-3-induced T-cell lymphomas, harbors a putative proto-oncogene with homology to the septin gene family. J Virol. 2000;74:2161-8 pubmed
..Together these findings raise the possibility that a proto-oncogene belonging to the septin family, and located about 15 kb upstream of the provirus integration sites, is involved in murine leukemia virus-induced T-cell lymphomagenesis. ..