Experts and Doctors on tubulin in France

Summary

Locale: France
Topic: tubulin

Top Publications

  1. Giraud F, Dupont J, Haon M, Bouzid O, Alibeu O, Navarro D, et al. Phylogenetic analysis of the Aspergillus niger aggregate in relation to feruloyl esterase activity. Res Microbiol. 2007;158:413-9 pubmed
    ..niger formed a homogenous phylogenetic group distinguished by either zero or type A feruloyl esterase activity, while strains A. foetidus and A. tubingensis exhibited type B feruloyl esterase activity when grown on sugar beet pulp. ..
  2. Driowya M, Leclercq J, Verones V, Barczyk A, Lecoeur M, Renault N, et al. Synthesis of triazoloquinazolinone based compounds as tubulin polymerization inhibitors and vascular disrupting agents. Eur J Med Chem. 2016;115:393-405 pubmed publisher
    ..Upon treatment with compound 12d, remarkable cell shape changes as cell migration and tube formation were elicited in HUVECs, consistent with vasculature damaging activity. ..
  3. Prudent R, Vassal Stermann E, Nguyen C, Pillet C, Martinez A, Prunier C, et al. Pharmacological inhibition of LIM kinase stabilizes microtubules and inhibits neoplastic growth. Cancer Res. 2012;72:4429-39 pubmed
    ..Our findings suggest that LIM kinase functions as a signaling node that controls both actin and microtubule dynamics. LIM kinase may therefore represent a targetable enzyme for cancer treatment. ..
  4. Legrier M, Ducray A, Propper A, Kastner A. Region-specific expression of cell cycle inhibitors in the adult brain. Neuroreport. 2001;12:3127-31 pubmed
    ..The present data suggest that various CDK inhibitors may be involved in a region-specific fashion in the maintenance of nerve cell quiescence in adults. ..
  5. Chernov K, Mechulam A, Popova N, Pastre D, Nadezhdina E, Skabkina O, et al. YB-1 promotes microtubule assembly in vitro through interaction with tubulin and microtubules. BMC Biochem. 2008;9:23 pubmed publisher
    ..Finally, we demonstrated that tubulin interferes with RNA:YB-1 complexes. These results suggest that YB-1 may regulate microtubule assembly in vivo and that its interaction with tubulin may contribute to the control of mRNA translation. ..
  6. Silvestre A, Sauve C, Cortet J, Cabaret J. Contrasting genetic structures of two parasitic nematodes, determined on the basis of neutral microsatellite markers and selected anthelmintic resistance markers. Mol Ecol. 2009;18:5086-100 pubmed publisher
  7. Lippens G, Landrieu I, Smet C, Huvent I, Gandhi N, Gigant B, et al. NMR Meets Tau: Insights into Its Function and Pathology. Biomolecules. 2016;6: pubmed publisher
    ..Finally, we will discuss other post-translational modifications of Tau and its interaction with other cellular factors in relationship to its (dys)function. ..
  8. Delépine C, Meziane H, Nectoux J, Opitz M, Smith A, Ballatore C, et al. Altered microtubule dynamics and vesicular transport in mouse and human MeCP2-deficient astrocytes. Hum Mol Genet. 2016;25:146-57 pubmed publisher
    ..These findings represent a first step toward the validation of an innovative treatment for RTT. ..
  9. Fournier E, Giraud T, Albertini C, Brygoo Y. Partition of the Botrytis cinerea complex in France using multiple gene genealogies. Mycologia. 2005;97:1251-67 pubmed
    ..cinerea Group II. This also was supported by recombination rates at each locus. Multiple-gene genealogies showed their utility by providing a relevant partition criterion for the B. cinerea complex. ..

More Information

Publications80

  1. Malaterre J, Strambi C, Aouane A, Strambi A, Rougon G, Cayre M. A novel role for polyamines in adult neurogenesis in rodent brain. Eur J Neurosci. 2004;20:317-30 pubmed
    ..The present study reveals common mechanisms underlying birth of new neurons in vertebrate and invertebrate species. ..
  2. Querolle O, Dubois J, Thoret S, Roussi F, Montiel Smith S, Guéritte F, et al. Synthesis of novel macrocyclic docetaxel analogues. Influence of their macrocyclic ring size on tubulin activity. J Med Chem. 2003;46:3623-30 pubmed
    ..The most active taxoid 3d appears to adopt a conformation that is between the "nonpolar" and T-shaped forms. ..
  3. Silvestre A, Cabaret J. Mutation in position 167 of isotype 1 beta-tubulin gene of Trichostrongylid nematodes: role in benzimidazole resistance?. Mol Biochem Parasitol. 2002;120:297-300 pubmed
  4. Silvestre A, Humbert J. Diversity of benzimidazole-resistance alleles in populations of small ruminant parasites. Int J Parasitol. 2002;32:921-8 pubmed
    ..Thus, the origin of benzimidazole-resistance alleles in trichostrongylid nematodes seems to involve primarily the selection of rare alleles and possibly of spontaneous mutations. ..
  5. Dimitrov A, Quesnoit M, Moutel S, Cantaloube I, Poüs C, Perez F. Detection of GTP-tubulin conformation in vivo reveals a role for GTP remnants in microtubule rescues. Science. 2008;322:1353-6 pubmed publisher
    ..Observations in living cells suggested that these GTP remnants may be responsible for the rescue events in which microtubules recover from catastrophe. ..
  6. Louvet Vallee S, Vinot S, Maro B. Mitotic spindles and cleavage planes are oriented randomly in the two-cell mouse embryo. Curr Biol. 2005;15:464-9 pubmed
    ..These studies show that cleavage planes are oriented randomly in two-cell embryos. This argues against a prepatterning of the mouse embryo before compaction. ..
  7. Wicker Planquart C, Stoppin Mellet V, Blanchoin L, Vantard M. Interactions of tobacco microtubule-associated protein MAP65-1b with microtubules. Plant J. 2004;39:126-34 pubmed
    ..In vitro, NtMAP65-1b stabilizes microtubules against depolymerization induced by cold, but not against katanin-induced destabilization. The biological implications of these results are discussed. ..
  8. Gorvel J. Microbiology. Bacterial bushwacking through a microtubule jungle. Science. 2006;314:931-2 pubmed
  9. Redeker V. Mass spectrometry analysis of C-terminal posttranslational modifications of tubulins. Methods Cell Biol. 2010;95:77-103 pubmed publisher
    ..Complementary MS-based approaches useful to document the structure of the highly heterogeneous posttranslational polymodifications will also be presented. ..
  10. Perdiz D, Mackeh R, Poüs C, Baillet A. The ins and outs of tubulin acetylation: more than just a post-translational modification?. Cell Signal. 2011;23:763-71 pubmed publisher
    ..It also points out that tubulin acetylation should no longer be seen as a passive marker of microtubule stability, but as a broad regulator of microtubule functions. ..
  11. Plassart Schiess E, Baulieu E. Neurosteroids: recent findings. Brain Res Brain Res Rev. 2001;37:133-40 pubmed
    ..This novel mechanism may play a role in regulating microtubule formation and dynamics and thus neuronal plasticity and function. ..
  12. Wehenkel A, Janke C. Towards elucidating the tubulin code. Nat Cell Biol. 2014;16:303-5 pubmed publisher
    ..The generation of different tubulin variants in yeast now demonstrates how single amino-acid differences or post-translational modifications can modulate the behaviour of selected molecular motors. ..
  13. Janke C, BULINSKI J. Post-translational regulation of the microtubule cytoskeleton: mechanisms and functions. Nat Rev Mol Cell Biol. 2011;12:773-86 pubmed publisher
  14. Humbert J, Cabaret J, Elard L, Leignel V, Silvestre A. Molecular approaches to studying benzimidazole resistance in trichostrongylid nematode parasites of small ruminants. Vet Parasitol. 2001;101:405-14 pubmed
    ..The results demonstrate the value of a multidisciplinary approach to the study of anthelmintic resistance, combining molecular, ecological and epidemiological techniques. ..
  15. Kann M, Soues S, Levilliers N, Fouquet J. Glutamylated tubulin: diversity of expression and distribution of isoforms. Cell Motil Cytoskeleton. 2003;55:14-25 pubmed
    ..These new data emphasize the importance of glutamylation in all types of microtubules and strengthen the hypothesis of its role in the regulation of the intracellular traffic and flagellar motility. ..
  16. Barbier P, Gregoire C, Devred F, Sarrazin M, Peyrot V. In vitro effect of cryptophycin 52 on microtubule assembly and tubulin: molecular modeling of the mechanism of action of a new antimitotic drug. Biochemistry. 2001;40:13510-9 pubmed
  17. Bouchet A, Boumendjel A, Khalil E, Serduc R, Brauer E, Siegbahn E, et al. Chalcone JAI-51 improves efficacy of synchrotron microbeam radiation therapy of brain tumors. J Synchrotron Radiat. 2012;19:478-82 pubmed publisher
    ..The combination of MRT and JAI-51 increases the survival of 9LGS-bearing rats by inducing endoreduplication of DNA and tumor cell death; further, it slowed the onset of tumor growth resumption two weeks after treatment. ..
  18. Délye C, Menchari Y, Michel S, Darmency H. Molecular bases for sensitivity to tubulin-binding herbicides in green foxtail. Plant Physiol. 2004;136:3920-32 pubmed
  19. Represa A, Trabelsi Terzidis H, Plantier M, Fattoum A, Jorquera I, Agassandian C, et al. Distribution of caldesmon and of the acidic isoform of calponin in cultured cerebellar neurons and in different regions of the rat brain: an immunofluorescence and confocal microscopy study. Exp Cell Res. 1995;221:333-43 pubmed
    ..These results are compatible with the functional role of caldesmon and calponin in the regulation of the actomyosin activity as described by others and suggest that they are part of the contractile apparatus of neural cells. ..
  20. Seemanpillai M, Elamawi R, Ritzenthaler C, Heinlein M. Challenging the role of microtubules in Tobacco mosaic virus movement by drug treatments is disputable. J Virol. 2006;80:6712-5 pubmed
    ..Thus, results obtained from studies using microtubule inhibitors may have to remain open to interpretation with regard to the involvement of microtubules in viral RNA trafficking. ..
  21. Seltzer V, Janski N, Canaday J, Herzog E, Erhardt M, Evrard J, et al. Arabidopsis GCP2 and GCP3 are part of a soluble gamma-tubulin complex and have nuclear envelope targeting domains. Plant J. 2007;52:322-31 pubmed
    ..We propose that regulated recruitment of soluble gamma-tubulin-containing complexes is responsible for nucleation at dispersed sites in plant cells and contributes to the formation and organization of the various MT arrays. ..
  22. Pastuglia M, Azimzadeh J, Goussot M, Camilleri C, Belcram K, Evrard J, et al. Gamma-tubulin is essential for microtubule organization and development in Arabidopsis. Plant Cell. 2006;18:1412-25 pubmed
    ..These results establish the central role of gamma-tubulin in the formation and organization of microtubule arrays in Arabidopsis. ..
  23. Faigle W, Colucci Guyon E, Louvard D, Amigorena S, Galli T. Vimentin filaments in fibroblasts are a reservoir for SNAP23, a component of the membrane fusion machinery. Mol Biol Cell. 2000;11:3485-94 pubmed
    ..The vimentin-associated pool of SNAP23 can therefore be a reservoir, which would supply the plasma membrane fusion machinery, in fibroblasts. Our observation points to a yet unexplored role of intermediate filaments. ..
  24. Hudson C, Lemaire P. Induction of anterior neural fates in the ascidian Ciona intestinalis. Mech Dev. 2001;100:189-203 pubmed
    ..Our results, however, indicate that bFGF can only induce a subset of the responses of the endogenous inducer, suggesting that additional signals in the embryo are necessary to induce a fully patterned nervous system. ..
  25. Hoffner G, Kahlem P, Djian P. Perinuclear localization of huntingtin as a consequence of its binding to microtubules through an interaction with beta-tubulin: relevance to Huntington's disease. J Cell Sci. 2002;115:941-8 pubmed
    ..The mutational glutamine expansion then promotes insolubility and results in an inclusion. ..
  26. Janke C, Kneussel M. Tubulin post-translational modifications: encoding functions on the neuronal microtubule cytoskeleton. Trends Neurosci. 2010;33:362-72 pubmed publisher
    ..Recent studies are also discussed in relation to how the combinatorial use of tubulin modifications could generate a dynamic microtubule code, and how such a code might regulate basic as well as higher-order neuronal functions. ..
  27. Duflos A, Kruczynski A, Barret J. Novel aspects of natural and modified vinca alkaloids. Curr Med Chem Anticancer Agents. 2002;2:55-70 pubmed
    ..Thus, Vinca alkaloids remain a drug family with a continuing interest for future anticancer therapy. ..
  28. Banora M, Rodiuc N, Baldacci Cresp F, Smertenko A, Bleve Zacheo T, Mellilo M, et al. Feeding cells induced by phytoparasitic nematodes require ?-tubulin ring complex for microtubule reorganization. PLoS Pathog. 2011;7:e1002343 pubmed publisher
  29. Combes S, Barbier P, Douillard S, McLeer Florin A, Bourgarel Rey V, Pierson J, et al. Synthesis and biological evaluation of 4-arylcoumarin analogues of combretastatins. Part 2. J Med Chem. 2011;54:3153-62 pubmed publisher
    ..The calculations suggested that the presence of a methoxy group out of the plane of the chromenone moiety is an important steric hindrance factor embedding the accessibility of those molecules inside the binding pocket on tubulin...
  30. Blanco I, Kuchenbaecker K, Cuadras D, Wang X, Barrowdale D, de Garibay G, et al. Assessing associations between the AURKA-HMMR-TPX2-TUBG1 functional module and breast cancer risk in BRCA1/2 mutation carriers. PLoS ONE. 2015;10:e0120020 pubmed publisher
    ..Together, the results of this study support the hypothesis of a causative link between altered function of AURKA-HMMR-TPX2-TUBG1 and breast carcinogenesis in BRCA1/2 mutation carriers. ..
  31. Lehmann S, Bourgoin Voillard S, Seve M, Rachidi W. Tubulin Beta-3 Chain as a New Candidate Protein Biomarker of Human Skin Aging: A Preliminary Study. Oxid Med Cell Longev. 2017;2017:5140360 pubmed publisher
    ..Change of expression of tubulin beta-3 chain was confirmed by western blot on samples originated from several donors. Thus, this study suggested the tubulin beta-3 chain has a promising biomarker in skin aging. ..
  32. Orpinell M, Fournier M, Riss A, Nagy Z, Krebs A, Frontini M, et al. The ATAC acetyl transferase complex controls mitotic progression by targeting non-histone substrates. EMBO J. 2010;29:2381-94 pubmed publisher
    ..Thus, we have uncovered an essential function for ATAC in regulating Cyclin A activity and consequent mitotic progression. ..
  33. Barbier P, Dorleans A, Devred F, Sanz L, Allegro D, Alfonso C, et al. Stathmin and interfacial microtubule inhibitors recognize a naturally curved conformation of tubulin dimers. J Biol Chem. 2010;285:31672-81 pubmed publisher
    ..It is tempting to speculate that stathmin evolved to recognize curved structures in unassembled and disassembling tubulin, thus regulating microtubule assembly. ..
  34. Debec A, Detraves C, Montmory C, Geraud G, Wright M. Polar organization of gamma-tubulin in acentriolar mitotic spindles of Drosophila melanogaster cells. J Cell Sci. 1995;108 ( Pt 7):2645-53 pubmed
  35. Ravelli R, Gigant B, Curmi P, Jourdain I, Lachkar S, Sobel A, et al. Insight into tubulin regulation from a complex with colchicine and a stathmin-like domain. Nature. 2004;428:198-202 pubmed
    ..Moreover, the tubulin-colchicine complex sheds light on the mechanism of colchicine's activity: we show that colchicine binds at a location where it prevents curved tubulin from adopting a straight structure, which inhibits assembly. ..
  36. Maro G, Vermeren M, Voiculescu O, Melton L, Cohen J, Charnay P, et al. Neural crest boundary cap cells constitute a source of neuronal and glial cells of the PNS. Nat Neurosci. 2004;7:930-8 pubmed
    ..These data indicate that BC cells constitute a source of peripheral nervous system (PNS) components that, after the major neural crest ventrolateral migratory stream, feeds a secondary wave of migration to the PNS. ..
  37. Bre M, Redeker V, Vinh J, Rossier J, Levilliers N. Tubulin polyglycylation: differential posttranslational modification of dynamic cytoplasmic and stable axonemal microtubules in paramecium. Mol Biol Cell. 1998;9:2655-65 pubmed
    ..These observations establish that polyglycylation is reversible and indicate that, in vivo, an equilibrium between glycylating and deglycylating enzymes might be responsible for the length of the oligoglycine side chains of tubulin...
  38. Erhardt M, Stoppin Mellet V, Campagne S, Canaday J, Mutterer J, Fabian T, et al. The plant Spc98p homologue colocalizes with gamma-tubulin at microtubule nucleation sites and is required for microtubule nucleation. J Cell Sci. 2002;115:2423-31 pubmed
    ..Microtubule nucleation involving Spc98p-containing gamma-tubulin complexes could then be conserved among all eukaryotes, despite differences in structure and spatial distribution of microtubule organizing centers. ..
  39. Guillaud L, Bosc C, Fourest Lieuvin A, Denarier E, Pirollet F, Lafanechere L, et al. STOP proteins are responsible for the high degree of microtubule stabilization observed in neuronal cells. J Cell Biol. 1998;142:167-79 pubmed
    ..Thus, STOP proteins are responsible for microtubule stabilization in neurons, and are apparently required for normal neurite formation. ..
  40. Serrano N, Brock H, Maschat F. beta3-tubulin is directly repressed by the engrailed protein in Drosophila. Development. 1997;124:2527-36 pubmed
    ..Finally, two different sets of Engrailed binding sites are shown to be involved in the early and late regulation of beta3-tubulin by Engrailed during embryogenesis. ..
  41. Cuif M, Possmayer F, Zander H, Bordes N, Jollivet F, Couedel Courteille A, et al. Characterization of GAPCenA, a GTPase activating protein for Rab6, part of which associates with the centrosome. EMBO J. 1999;18:1772-82 pubmed
    ..Moreover, GAPCenA was found to form complexes with cytosolic gamma-tubulin and to play a role in microtubule nucleation. Therefore, GAPCenA may be involved in the coordination of microtubule and Golgi dynamics during the cell cycle. ..
  42. Gueth Hallonet C, Antony C, Aghion J, Santa Maria A, Lajoie Mazenc I, Wright M, et al. gamma-Tubulin is present in acentriolar MTOCs during early mouse development. J Cell Sci. 1993;105 ( Pt 1):157-66 pubmed
    ..In parallel, electron microscopy studies allowed us to detect centrioles for the first time at the 64-cell stage. The possible roles of gamma-tubulin in microtubule nucleation and in centrosome maturation are discussed. ..
  43. Grava S, Dumoulin P, Madania A, Tarassov I, Winsor B. Functional analysis of six genes from chromosomes XIV and XV of Saccharomyces cerevisiae reveals YOR145c as an essential gene and YNL059c/ARP5 as a strain-dependent essential gene encoding nuclear proteins. Yeast. 2000;16:1025-33 pubmed
    ..The vectors containing the deletion cassettes and the cognate wild-type genes, the oligonucleotides, and the deletant strains are available from the EUROFAN resource centre EUROSCARF (Frankfurt). ..
  44. Faure A, Grunwald D, Moutin M, Hilly M, Mauger J, Marty I, et al. Developmental expression of the calcium release channels during early neurogenesis of the mouse cerebral cortex. Eur J Neurosci. 2001;14:1613-22 pubmed
    ..Altogether, they provide a molecular basis for analyzing the developmental modulation of calcium signals useful for neurogenesis progression. ..
  45. Brants J, Semenchenko K, Wasylyk C, Robert A, Carles A, Zambrano A, et al. Tubulin tyrosine ligase like 12, a TTLL family member with SET- and TTL-like domains and roles in histone and tubulin modifications and mitosis. PLoS ONE. 2012;7:e51258 pubmed publisher
    ..These results suggest that hTTLL12 has non-catalytic functions related to tubulin and histone modification, which could be linked to its effects on mitosis and chromosome number stability. ..
  46. Mialhe A, Lafanechere L, Treilleux I, Peloux N, Dumontet C, Bremond A, et al. Tubulin detyrosination is a frequent occurrence in breast cancers of poor prognosis. Cancer Res. 2001;61:5024-7 pubmed
    ..Our study shows that tubulin detyrosination is a frequent occurrence in breast cancer, easy to detect, and linked to tumor aggressiveness. ..
  47. Chambraud B, Belabes H, Fontaine Lenoir V, Fellous A, Baulieu E. The immunophilin FKBP52 specifically binds to tubulin and prevents microtubule formation. FASEB J. 2007;21:2787-97 pubmed
    ..Collectively, our data define an unexpected property of FKBP52 as a novel regulator of microtubule dynamics. The possible role of microtubule formation and tubulin binding of other immunophilins such as FKBP12 and FKBP51 is discussed. ..
  48. Eot Houllier G, Venoux M, Vidal Eychenié S, Hoang M, Giorgi D, Rouquier S. Plk1 regulates both ASAP localization and its role in spindle pole integrity. J Biol Chem. 2010;285:29556-68 pubmed publisher
    ..These data reveal a novel function of ASAP in centrosome integrity. Our results highlight dual ASAP regulation by Plk1 and further confirm the importance of ASAP for spindle pole organization, bipolar spindle assembly, and mitosis. ..
  49. Laurine E, Lafitte D, Grégoire C, Seree E, Loret E, Douillard S, et al. Specific binding of dehydroepiandrosterone to the N terminus of the microtubule-associated protein MAP2. J Biol Chem. 2003;278:29979-86 pubmed
    ..This work suggests that DHEA can directly influence brain plasticity via MAP2C binding. It opens interesting ways for understanding the role of DHEA in the brain. ..
  50. Paschaki M, Lin S, Wong R, Finnell R, Dolle P, Niederreither K. Retinoic acid-dependent signaling pathways and lineage events in the developing mouse spinal cord. PLoS ONE. 2012;7:e32447 pubmed publisher
  51. Drévillon L, Megarbane A, Demeer B, Matar C, Benit P, Briand Suleau A, et al. KBP-cytoskeleton interactions underlie developmental anomalies in Goldberg-Shprintzen syndrome. Hum Mol Genet. 2013;22:2387-99 pubmed publisher
    ..The KBP interactions with actin filaments and microtubules (MTs) demonstrated in our study constitute the first evidence that an actin MT cross-link protein is involved in neuronal development in humans. ..
  52. Bouissou A, V rollet C, de Forges H, Haren L, Bella che Y, Perez F, et al. ?-Tubulin Ring Complexes and EB1 play antagonistic roles in microtubule dynamics and spindle positioning. EMBO J. 2014;33:114-28 pubmed publisher
    ..Therefore, we propose a role for ?-TuRCs in regulating spindle positioning by controlling the stability of astral MTs...
  53. Nieoullon V, Belvindrah R, Rougon G, Chazal G. mCD24 regulates proliferation of neuronal committed precursors in the subventricular zone. Mol Cell Neurosci. 2005;28:462-74 pubmed
    ..We concluded that mCD24 acts cell nonautonomously to regulate transit-amplifying cells proliferation and/or differentiation. ..
  54. Terry S, Ploussard G, Allory Y, Nicolaiew N, Boissiere Michot F, Maille P, et al. Increased expression of class III beta-tubulin in castration-resistant human prostate cancer. Br J Cancer. 2009;101:951-6 pubmed publisher
  55. Vincenot L, Balesdent M, Li H, Barbetti M, Sivasithamparam K, Gout L, et al. Occurrence of a new subclade of Leptosphaeria biglobosa in Western Australia. Phytopathology. 2008;98:321-9 pubmed publisher
    ..Westar. The pathogenicity of L. biglobosa 'occiaustralensis' to cotyledons of most oilseed rape genotypes was higher than that of L. biglobosa 'canadensis' or L. biglobosa 'australensis' isolates. ..
  56. Tassin A, Celati C, Moudjou M, Bornens M. Characterization of the human homologue of the yeast spc98p and its association with gamma-tubulin. J Cell Biol. 1998;141:689-701 pubmed
    ..Finally, affinity-purified antibodies against Spc98p inhibit microtubule nucleation on isolated centrosomes, as well as in microinjected cells, suggesting that this novel protein is indeed required for the nucleation reaction. ..
  57. Burgess A, Labbe J, Vigneron S, Bonneaud N, Strub J, Van Dorsselaer A, et al. Chfr interacts and colocalizes with TCTP to the mitotic spindle. Oncogene. 2008;27:5554-66 pubmed publisher
  58. Nicolas C, Park K, El Harchi A, Camonis J, Kass R, Escande D, et al. IKs response to protein kinase A-dependent KCNQ1 phosphorylation requires direct interaction with microtubules. Cardiovasc Res. 2008;79:427-35 pubmed publisher
    ..We propose that the KCNQ1-KCNE1 channel directly interacts with microtubules and that this interaction plays a major role in coupling PKA-dependent phosphorylation of KCNQ1 with I(Ks) activation. ..
  59. Hamed W, Brajeul S, Mahuteau Betzer F, Thoison O, Mons S, Delpech B, et al. Oblongifolins A-D, polyprenylated benzoylphloroglucinol derivatives from Garcinia oblongifolia. J Nat Prod. 2006;69:774-7 pubmed
    ..The biological activity of these compounds concerning interactions with tubulin was investigated...
  60. Bonnet C, Denarier E, Bosc C, Lazereg S, Denoulet P, Larcher J. Interaction of STOP with neuronal tubulin is independent of polyglutamylation. Biochem Biophys Res Commun. 2002;297:787-93 pubmed
    ..And contrary to the other microtubule-associated proteins tested so far, STOP can bind quantitatively to any tubulin isoform whatever its degree of polyglutamylation. ..
  61. Andreassen P, Lohez O, Lacroix F, Margolis R. Tetraploid state induces p53-dependent arrest of nontransformed mammalian cells in G1. Mol Biol Cell. 2001;12:1315-28 pubmed
    ..As such, the tetraploidy checkpoint may be a critical activity of p53 in its role of ensuring genomic integrity. ..
  62. Bouchet B, Puisieux A, Galmarini C. ?III-Tubulin is required for interphase microtubule dynamics in untransformed human mammary epithelial cells. Eur J Cell Biol. 2011;90:872-8 pubmed publisher
    ..This strongly suggests that ?III-tubulin is an essential regulator of interphase microtubule functions in normal breast epithelium cells. ..
  63. El Chartouni L, Tisserant B, Siah A, Duyme F, Leducq J, Deweer C, et al. Genetic diversity and population structure in French populations of Mycosphaerella graminicola. Mycologia. 2011;103:764-74 pubmed publisher
    ..Our results highlighted the potential for the adaptation of the fungus to local conditions, leading to genetic clusters among the French population of the fungus as well as genotype flow between regional clusters. ..
  64. Wasylyk C, Zambrano A, Zhao C, Brants J, Abecassis J, Schalken J, et al. Tubulin tyrosine ligase like 12 links to prostate cancer through tubulin posttranslational modification and chromosome ploidy. Int J Cancer. 2010;127:2542-53 pubmed publisher
    ..This study contributes a step toward developing more selective agents targeting microtubules, an already successful target for tumor therapy. ..
  65. Lachkar S, Lebois M, Steinmetz M, Guichet A, Lal N, Curmi P, et al. Drosophila stathmins bind tubulin heterodimers with high and variable stoichiometries. J Biol Chem. 2010;285:11667-80 pubmed publisher
    ..Altogether, our results reveal that the single Drosophila stathmin gene codes for a stathmin family similar to the multigene vertebrate one, but with particular tubulin binding properties. ..
  66. Seve P, Reiman T, Dumontet C. The role of betaIII tubulin in predicting chemoresistance in non-small cell lung cancer. Lung Cancer. 2010;67:136-43 pubmed publisher
    ..This paper reviews the evidence base for betaIII tubulin expression as a prognostic and predictive biomarker in NSCLC and briefly explores the implications for clinical decision making of this and other emerging biomarkers. ..
  67. Ducki S. Antimitotic chalcones and related compounds as inhibitors of tubulin assembly. Anticancer Agents Med Chem. 2009;9:336-47 pubmed
    ..This activity has also been associated with their anti-vascular activity. This review focuses on the development of chalcones and related analogues as antimitotic agents. ..
  68. Delgehyr N, Sillibourne J, Bornens M. Microtubule nucleation and anchoring at the centrosome are independent processes linked by ninein function. J Cell Sci. 2005;118:1565-75 pubmed
    ..We therefore propose that ninein constitutes a molecular link between microtubule-nucleation and -anchoring activities at the centrosome. ..
  69. Fourest Lieuvin A, Peris L, Gache V, Garcia Saez I, Juillan Binard C, Lantez V, et al. Microtubule regulation in mitosis: tubulin phosphorylation by the cyclin-dependent kinase Cdk1. Mol Biol Cell. 2006;17:1041-50 pubmed
    ..These data indicate that phosphorylation of tubulin by Cdk1 could be involved in the regulation of microtubule dynamics during mitosis. ..
  70. Boyault C, Zhang Y, Fritah S, Caron C, Gilquin B, Kwon S, et al. HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates. Genes Dev. 2007;21:2172-81 pubmed
    ..HDAC6 therefore appears as a master regulator of the cell protective response to cytotoxic protein aggregate formation. ..
  71. Le Gac M, Hood M, Fournier E, Giraud T. Phylogenetic evidence of host-specific cryptic species in the anther smut fungus. Evolution. 2007;61:15-26 pubmed