Genomes and Genes
Experts and Doctors on transcription factors in United Kingdom
Locale: United Kingdom
Topic: transcription factors
Publications365 found, 100 shown here
- Thaventhiran J, Hoffmann A, Magiera L, de la Roche M, Lingel H, Brunner Weinzierl M, et al. Activation of the Hippo pathway by CTLA-4 regulates the expression of Blimp-1 in the CD8+ T cell. Proc Natl Acad Sci U S A. 2012;109:E2223-9 pubmed publisher..The CTLA-4/Hippo pathway/Blimp-1 system may couple terminal differentiation of CD8(+) T cell with the magnitude of clonal expansion. ..
- Davis M, Abreu Goodger C, van Dongen S, Lu D, Tate P, Bartonicek N, et al. Large-scale identification of microRNA targets in murine Dgcr8-deficient embryonic stem cell lines. PLoS ONE. 2012;7:e41762 pubmed publisher..Additionally, our experiments have revealed a novel candidate for Dgcr8-independent microRNA genesis and highlighted the challenges currently facing miRNA annotation. ..
- Webster S, Waite S, Cookson V, Warren A, Khan R, Gandhi S, et al. Regulation of GTP-binding protein (G?s) expression in human myometrial cells: a role for tumor necrosis factor in modulating G?s promoter acetylation by transcriptional complexes. J Biol Chem. 2013;288:6704-16 pubmed publisher..This was associated with increased levels of histone deacetylase-1 and surprisingly an increase in H4K8 acetylation. The latter is discussed herein. ..
- Gilmour P, Brown D, Beswick P, MacNee W, Rahman I, Donaldson K. Free radical activity of industrial fibers: role of iron in oxidative stress and activation of transcription factors. Environ Health Perspect. 1997;105 Suppl 5:1313-7 pubmed..Although this was not related to iron release or ability to deplete macrophage GSH at 4 hr, GSH does play a role in activation of NF kappa B. ..
- Bannister A, Miska E. Regulation of gene expression by transcription factor acetylation. Cell Mol Life Sci. 2000;57:1184-92 pubmed..Moreover, a conserved domain, the bromodomain, has been implicated in the binding of acetylated peptides, suggesting a role for acetylation in intracellular signalling. ..
- Dubois L, Lecourtois M, Alexandre C, Hirst E, Vincent J. Regulated endocytic routing modulates wingless signaling in Drosophila embryos. Cell. 2001;105:613-24 pubmed
- Aranda A, Proudfoot N. Transcriptional termination factors for RNA polymerase II in yeast. Mol Cell. 2001;7:1003-11 pubmed..Deletion of res2 in both fission and budding yeast results in a defect in 3' end formation. This raises the possibility that RNAP II transcriptional termination may in some situations be integrated with cell cycle events. ..
- Harmar A, Marston H, Shen S, Spratt C, West K, Sheward W, et al. The VPAC(2) receptor is essential for circadian function in the mouse suprachiasmatic nuclei. Cell. 2002;109:497-508 pubmed..Moreover, the mutants fail to show acute induction of mPer1 and mPer2 by nocturnal illumination. This study highlights the role of intercellular neuropeptidergic signaling in maintenance of circadian function within the SCN. ..
- Teh M, Wong S, Neill G, Ghali L, Philpott M, Quinn A. FOXM1 is a downstream target of Gli1 in basal cell carcinomas. Cancer Res. 2002;62:4773-80 pubmed
- Gottlob I, Jain S, Engle E. Elevation of one eye during tooth brushing. Am J Ophthalmol. 2002;134:459-60 pubmed..This aberrant innervation supports a primary developmental abnormality of the cranial nerves in CFEOM. ..
- Mohammad Qureshi S, Haddad R, Hemingway E, Richardson J, Pavitt G. Critical contacts between the eukaryotic initiation factor 2B (eIF2B) catalytic domain and both eIF2beta and -2gamma mediate guanine nucleotide exchange. Mol Cell Biol. 2007;27:5225-34 pubmed..In contrast, all three residues are critical for interaction with eIF2gamma. These data show that multiple contacts between eIF2gamma and eIF2Bepsilon mediate nucleotide exchange. ..
- Cooper S, Murawsky C, Lowe N, Travers A. Two modes of degradation of the tramtrack transcription factors by Siah homologues. J Biol Chem. 2008;283:1076-83 pubmed..We speculate that SinaH may be involved in regulating the levels of developmentally important transcription factors. ..
- Soriano F, LÃ©veillÃ© F, Papadia S, Bell K, Puddifoot C, Hardingham G. Neuronal activity controls the antagonistic balance between peroxisome proliferator-activated receptor-Î³ coactivator-1Î± and silencing mediator of retinoic acid and thyroid hormone receptors in regulating antioxidant defenses. Antioxid Redox Signal. 2011;14:1425-36 pubmed publisher..Further, this coactivator-corepressor antagonism is regulated by the activity status of the cell, with implications for neuronal viability. ..
- Walker J, Kwon S, Badenhorst P, East P, McNeill H, Svejstrup J. Role of elongator subunit Elp3 in Drosophila melanogaster larval development and immunity. Genetics. 2011;187:1067-75 pubmed publisher..Together, these data demonstrate that Drosophila Elp3 is essential for viability, normal development, and hematopoiesis and suggest a functional overlap with the chromatin remodeler Domino. ..
- Fonseca B, Alain T, Finestone L, Huang B, Rolfe M, Jiang T, et al. Pharmacological and genetic evaluation of proposed roles of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK), extracellular signal-regulated kinase (ERK), and p90(RSK) in the control of mTORC1 protein signaling by p. J Biol Chem. 2011;286:27111-22 pubmed publisher..This study provides important information for the design of efficient strategies to combat the hyperactivation of mTORC1 signaling by oncogenic pathways. ..
- Din F, Valanciute A, Houde V, Zibrova D, Green K, Sakamoto K, et al. Aspirin inhibits mTOR signaling, activates AMP-activated protein kinase, and induces autophagy in colorectal cancer cells. Gastroenterology. 2012;142:1504-15.e3 pubmed publisher..Aspirin is an inhibitor of mTOR and an activator of AMPK, targeting regulators of intracellular energy homeostasis and metabolism. These could contribute to its protective effects against development of CRC. ..
- Cevik V, Kidd B, Zhang P, Hill C, Kiddle S, Denby K, et al. MEDIATOR25 acts as an integrative hub for the regulation of jasmonate-responsive gene expression in Arabidopsis. Plant Physiol. 2012;160:541-55 pubmed publisher..These results suggest an important role for MED25 as an integrative hub within the Mediator complex during the regulation of JA-associated gene expression. ..
- Wilson V, Beddington R. Expression of T protein in the primitive streak is necessary and sufficient for posterior mesoderm movement and somite differentiation. Dev Biol. 1997;192:45-58 pubmed..They also suggest that patterns of cell recruitment from the streak can be influenced by the level of T expression. ..
- Bouquin N, Johnson A, Morgan B, Johnston L. Association of the cell cycle transcription factor Mbp1 with the Skn7 response regulator in budding yeast. Mol Biol Cell. 1999;10:3389-400 pubmed..Thus, Skn7 and Mbp1 seem to form a transcription factor independent of MBF. Genetic data suggest that this new transcription factor could be involved in the bud-emergence process. ..
- Hughes C, Longo E, Phillips Jones M, Hussain R. Characterisation of the selective binding of antibiotics vancomycin and teicoplanin by the VanS receptor regulating type A vancomycin resistance in the enterococci. Biochim Biophys Acta Gen Subj. 2017;1861:1951-1959 pubmed publisher..Furthermore, binding of the antibiotics induced quicker, longer-lived phosphorylation states for VanSA, proposing them as activators of type A vancomycin resistance in the enterococci. ..
- Stevens C, Daniel R, Illing N, Errington J. Characterization of a sporulation gene, spoIVA, involved in spore coat morphogenesis in Bacillus subtilis. J Bacteriol. 1992;174:586-94 pubmed..This, together with the phenotypic properties of spoIVA mutations, would be in accord with the hypothesis that sigma E is only active after septation and in the mother cell compartment. ..
- Kwok C, Weller P, Guioli S, Foster J, Mansour S, Zuffardi O, et al. Mutations in SOX9, the gene responsible for Campomelic dysplasia and autosomal sex reversal. Am J Hum Genet. 1995;57:1028-36 pubmed..These findings are consistent with the hypothesis that CD results from haploinsufficiency of SOX9. ..
- Xu C, Chambers J, Solomon E. Complex regulation of the BRCA1 gene. J Biol Chem. 1997;272:20994-7 pubmed..We also discerned that there are striking differences in both the genomic organization and immediate cis-control elements of the BRCA1 gene between humans and mice. ..
- Tsuzuki S, Towatari M, Saito H, Enver T. Potentiation of GATA-2 activity through interactions with the promyelocytic leukemia protein (PML) and the t(15;17)-generated PML-retinoic acid receptor alpha oncoprotein. Mol Cell Biol. 2000;20:6276-86 pubmed
- Galanis A, Yang S, Sharrocks A. Selective targeting of MAPKs to the ETS domain transcription factor SAP-1. J Biol Chem. 2001;276:965-73 pubmed..Our data therefore demonstrate that a modular system of motifs is responsible for directing specific MAPK subtypes to SAP-1, but also point to important distinctions in the mechanism of action of the D-domain and FXF motif. ..
- Cabart P, Murphy S. BRFU, a TFIIB-like factor, is directly recruited to the TATA-box of polymerase III small nuclear RNA gene promoters through its interaction with TATA-binding protein. J Biol Chem. 2001;276:43056-64 pubmed..Therefore, the polymerase recruitment is not simply determined by the sequence of the TATA-box and immediate flanking sequences. ..
- Neill G, Ghali L, Green J, Ikram M, Philpott M, Quinn A. Loss of protein kinase Calpha expression may enhance the tumorigenic potential of Gli1 in basal cell carcinoma. Cancer Res. 2003;63:4692-7 pubmed..As BCCs have been proposed to originate from the ORS, loss of PKCalpha expression may be relevant to tumor formation; this may, in part, be because of the predicted increase in Gli1 transcriptional activity. ..
- Sathyamurthy A, Allen M, Murzin A, Bycroft M. Crystal structure of the malignant brain tumor (MBT) repeats in Sex Comb on Midleg-like 2 (SCML2). J Biol Chem. 2003;278:46968-73 pubmed..There are significant structural similarities to the Tudor, PWWP, and chromo domains, suggesting probable evolutionary relationships and functional similarities between the MBT repeats and these domains. ..
- Wyborn N, Stapleton M, Norte V, Roberts R, Grafton J, Green J. Regulation of Escherichia coli hemolysin E expression by H-NS and Salmonella SlyA. J Bacteriol. 2004;186:1620-8 pubmed..Finally, the identification of a SlyA binding site that overlaps the H-NS I site in PhlyE suggests a mechanism to explain how SlyA overproduction enhances hlyE expression by antagonizing the negative effects of H-NS. ..
- Cheng Y, Amoyel M, Qiu X, Jiang Y, Xu Q, Wilkinson D. Notch activation regulates the segregation and differentiation of rhombomere boundary cells in the zebrafish hindbrain. Dev Cell. 2004;6:539-50 pubmed..These findings reveal that Notch activation couples the regulation of location and differentiation in hindbrain boundary cells. Such coupling may be important for these cells to act as a stable signaling center. ..
- Fancy S, Zhao C, Franklin R. Increased expression of Nkx2.2 and Olig2 identifies reactive oligodendrocyte progenitor cells responding to demyelination in the adult CNS. Mol Cell Neurosci. 2004;27:247-54 pubmed..2 and Olig2 plays a critically important role in the differentiation of adult OPCs into remyelinating oligodendrocytes and that these genes may present novel targets for therapeutic manipulation in cases where remyelination is impaired. ..
- Hamada F, Bienz M. The APC tumor suppressor binds to C-terminal binding protein to divert nuclear beta-catenin from TCF. Dev Cell. 2004;7:677-85 pubmed..Our evidence indicates that APC is an adaptor between beta-catenin and CtBP and that CtBP lowers the availability of free nuclear beta-catenin for binding to TCF by sequestering APC/beta-catenin complexes. ..
- zur Lage P, Powell L, Prentice D, McLaughlin P, Jarman A. EGF receptor signaling triggers recruitment of Drosophila sense organ precursors by stimulating proneural gene autoregulation. Dev Cell. 2004;7:687-96 pubmed publisher..This exemplifies a simple and general mechanism for regulating the transition from competence to cell fate commitment whereby a cell signal directly targets the autoregulation of a selector gene...
- La Rocca S, Herbert R, Crooke H, Drew T, Wileman T, Powell P. Loss of interferon regulatory factor 3 in cells infected with classical swine fever virus involves the N-terminal protease, Npro. J Virol. 2005;79:7239-47 pubmed..The results demonstrate a novel viral evasion of innate host defenses, where interferon synthesis is prevented by inhibiting transcription of IRF3 in CSFV-infected cells. ..
- Razi M, Futter C. Distinct roles for Tsg101 and Hrs in multivesicular body formation and inward vesiculation. Mol Biol Cell. 2006;17:3469-83 pubmed
- Hatton Ellis E, Ainsworth C, Sushama Y, Wan S, Vijayraghavan K, Skaer H. Genetic regulation of patterned tubular branching in Drosophila. Proc Natl Acad Sci U S A. 2007;104:169-74 pubmed..We show that patterning of the tubule primordium into two distinct pairs is critical for the eversion of tubule branches, as well as for their asymmetric morphogenesis. ..
- Lindsay J, McDade S, Pickard A, McCloskey K, McCance D. Role of DeltaNp63gamma in epithelial to mesenchymal transition. J Biol Chem. 2011;286:3915-24 pubmed publisher..In summary, we show that p63 is involved in inhibiting EMT and reduction of certain p63 isoforms may be important in the development of epithelial cancers. ..
- Causier B, Ashworth M, Guo W, Davies B. The TOPLESS interactome: a framework for gene repression in Arabidopsis. Plant Physiol. 2012;158:423-38 pubmed publisher..They allow for predictions about new repressive transcription factors, corepressor interactions, and repression mechanisms and identify a wide range of plant processes that utilize TPL/TPR-mediated gene repression. ..
- Toloczko A, Guo F, Yuen H, Wen Q, Wood S, Ong Y, et al. Deubiquitinating Enzyme USP9X Suppresses Tumor Growth via LATS Kinase and Core Components of the Hippo Pathway. Cancer Res. 2017;77:4921-4933 pubmed publisher..Overall, these results strongly indicate that USP9X potentiates LATS kinase to suppress tumor growth. Cancer Res; 77(18); 4921-33. ©2017 AACR. ..
- Maclean K, See C, McKay I, Bustin S. The human immediate early gene BRF1 maps to chromosome 14q22-q24. Genomics. 1995;30:89-90 pubmed..This was confirmed by direct sequencing of the PCR fragment. Using fluorescence in situ hybridization, the chromosome localization of BRF1 was further determined as 14q22-q24. ..
- Uv A, Harrison E, Bray S. Tissue-specific splicing and functions of the Drosophila transcription factor Grainyhead. Mol Cell Biol. 1997;17:6727-35 pubmed
- Frayling T, McCarthy M, Walker M, Levy J, O Rahilly S, Hitman G, et al. No evidence for linkage at candidate type 2 diabetes susceptibility loci on chromosomes 12 and 20 in United Kingdom Caucasians. J Clin Endocrinol Metab. 2000;85:853-7 pubmed..We have not confirmed in United Kingdom Caucasians the evidence for linkage previously reported on 12q and 20q. Our results highlight further the problems of replicating previous positive linkage results across different ethnic groups. ..
- Castano E, Gross P, Wang Z, Roeder R, Oelgeschlager T. The C-terminal domain-phosphorylated IIO form of RNA polymerase II is associated with the transcription repressor NC2 (Dr1/DRAP1) and is required for transcription activation in human nuclear extracts. Proc Natl Acad Sci U S A. 2000;97:7184-9 pubmed..These findings reveal an unexpected link between NC2 and transcription activation and suggest that regulation of RNAP II transcription through reversible CTD phosphorylation might be more complex than previously proposed. ..
- Sellers L, Simon J, Lundahl T, Cousens D, Humphrey P, Barnard E. Adenosine nucleotides acting at the human P2Y1 receptor stimulate mitogen-activated protein kinases and induce apoptosis. J Biol Chem. 2001;276:16379-90 pubmed..The transient SAPK activity did not evoke transcription factor phosphorylation but was required for the P2Y(1) receptor-mediated apoptotic function. ..
- Kirby R, Hamilton G, Finnegan D, Johnson K, Jarman A. Drosophila homolog of the myotonic dystrophy-associated gene, SIX5, is required for muscle and gonad development. Curr Biol. 2001;11:1044-9 pubmed
- Bird C, Wyman M. Nitrate/nitrite assimilation system of the marine picoplanktonic cyanobacterium Synechococcus sp. strain WH 8103: effect of nitrogen source and availability on gene expression. Appl Environ Microbiol. 2003;69:7009-18 pubmed..The ecological implications of these findings are discussed in the context of the oligotrophic nature of oceanic surface waters in which Synechococcus spp. thrive. ..
- Bishop Bailey D, Walsh D, Warner T. Expression and activation of the farnesoid X receptor in the vasculature. Proc Natl Acad Sci U S A. 2004;101:3668-73 pubmed..FXR therefore is a functional protein in the vasculature that may provide a direct target for the treatment of proliferative and dyslipidaemic diseases. ..
- Huynh J, Munro T, Smith Litière K, Lepesant J, St Johnston D. The Drosophila hnRNPA/B homolog, Hrp48, is specifically required for a distinct step in osk mRNA localization. Dev Cell. 2004;6:625-35 pubmed..This suggests a new step in the localization pathway, which may correspond to the assembly of Staufen/oskar mRNA transport particles. ..
- Phillips R, Tyson Capper Née Pollard A, Bailey J, Robson S, Europe Finner G. Regulation of expression of the chorionic gonadotropin/luteinizing hormone receptor gene in the human myometrium: involvement of specificity protein-1 (Sp1), Sp3, Sp4, Sp-like proteins, and histone deacetylases. J Clin Endocrinol Metab. 2005;90:3479-90 pubmed
- Sutherland H, Newton K, Brownstein D, Holmes M, Kress C, Semple C, et al. Disruption of Ledgf/Psip1 results in perinatal mortality and homeotic skeletal transformations. Mol Cell Biol. 2006;26:7201-10 pubmed..The latter phenotypes suggest a role for Psip1 in the control of Hox expression and may also explain why PSIP1 (LEDGF) is found as a fusion partner with NUP98 in myeloid leukemias. ..
- Viola A, James L, Archer S, Dijk D. PER3 polymorphism and cardiac autonomic control: effects of sleep debt and circadian phase. Am J Physiol Heart Circ Physiol. 2008;295:H2156-63 pubmed publisher..Circadian phase modulated HR and HRV, but no interaction with genotype was observed. In conclusion, the PER3 polymorphism affects the sympathovagal balance in cardiac control in NREM sleep similar to the effect of sleep deprivation. ..
- Pradeepa M, McKenna F, Taylor G, Bengani H, Grimes G, Wood A, et al. Psip1/p52 regulates posterior Hoxa genes through activation of lncRNA Hottip. PLoS Genet. 2017;13:e1006677 pubmed publisher..Our data show a direct role for a lncRNA molecule in regulating the expression of developmentally-regulated mRNA genes in cis. ..
- Pearson S, Cawthorne M, Clapham J, Dunmore S, Holmes S, Moore G, et al. The thiazolidinedione insulin sensitiser, BRL 49653, increases the expression of PPAR-gamma and aP2 in adipose tissue of high-fat-fed rats. Biochem Biophys Res Commun. 1996;229:752-7 pubmed..PPAR-gamma and aP2 mRNA expression were significantly increased in the high-fat-fed rats treated with BRL 49653 (p < 0.01 and p < 0.001 respectively), but not in carbohydrate-fed rats. ..
- Bingham C, Ellard S, Cole T, Jones K, Allen L, Goodship J, et al. Solitary functioning kidney and diverse genital tract malformations associated with hepatocyte nuclear factor-1beta mutations. Kidney Int. 2002;61:1243-51 pubmed..This study further reinforces the variability of the renal and non-renal phenotypes associated with HNF-1beta mutations. ..
- Xu Q, Konta T, Furusu A, Nakayama K, Lucio Cazana J, Fine L, et al. Transcriptional induction of mitogen-activated protein kinase phosphatase 1 by retinoids. Selective roles of nuclear receptors and contribution to the antiapoptotic effect. J Biol Chem. 2002;277:41693-700 pubmed
- Chotard C, Leung W, Salecker I. glial cells missing and gcm2 cell autonomously regulate both glial and neuronal development in the visual system of Drosophila. Neuron. 2005;48:237-51 pubmed..Our findings further suggest that gcm genes regulate neurogenesis through collaboration with the Hedgehog-signaling pathway. ..
- Thomas J, Matak Vinkovic D, Van Molle I, Ciulli A. Multimeric complexes among ankyrin-repeat and SOCS-box protein 9 (ASB9), ElonginBC, and Cullin 5: insights into the structure and assembly of ECS-type Cullin-RING E3 ubiquitin ligases. Biochemistry. 2013;52:5236-46 pubmed publisher..The data reported here will also be of use for the future development of chemical probes to examine the biological function and modulation of other ECS-type CRL systems. ..
- Drowley L, Koonce C, Peel S, Jonebring A, Plowright A, Kattman S, et al. Human Induced Pluripotent Stem Cell-Derived Cardiac Progenitor Cells in Phenotypic Screening: A Transforming Growth Factor-Î² Type 1 Receptor Kinase Inhibitor Induces Efficient Cardiac Differentiation. Stem Cells Transl Med. 2016;5:164-74 pubmed publisher..In addition, this assay system was able to identify novel and potent inducers of differentiation and proliferation of induced pluripotent stem cell-derived cardiac progenitor cells. ..
- Roberts E, Deed R, Inoue T, Norton J, Sharrocks A. Id helix-loop-helix proteins antagonize pax transcription factor activity by inhibiting DNA binding. Mol Cell Biol. 2001;21:524-33 pubmed..Our results therefore demonstrate a novel facet of Id function in regulating cellular differentiation by functionally antagonizing the action of members of the Pax transcription factor family. ..
- Corless C, Guiver M, Borrow R, Edwards Jones V, Fox A, Kaczmarski E. Simultaneous detection of Neisseria meningitidis, Haemophilus influenzae, and Streptococcus pneumoniae in suspected cases of meningitis and septicemia using real-time PCR. J Clin Microbiol. 2001;39:1553-8 pubmed..The ctrA primer set used in the multiplex PCR was found to be more sensitive (P < 0.0001) than the ctrA primers that had been used for meningococcal PCR testing at that time. ..
- Martinez Argudo I, Little R, Dixon R. A crucial arginine residue is required for a conformational switch in NifL to regulate nitrogen fixation in Azotobacter vinelandii. Proc Natl Acad Sci U S A. 2004;101:16316-21 pubmed..vinelandii NifL in response to the redox and fixed-nitrogen status and is required for a conformational switch that inactivates the inhibitory function of NifL under conditions appropriate for nitrogen fixation...
- Gromak N, West S, Proudfoot N. Pause sites promote transcriptional termination of mammalian RNA polymerase II. Mol Cell Biol. 2006;26:3986-96 pubmed..Taken together, we provide new insights into the mechanism of pause site-mediated termination and establish a general role for the 5'-->3' exonuclease Xrn2 in Pol II termination. ..
- Meager A, Visvalingam K, Peterson P, Möll K, Murumägi A, Krohn K, et al. Anti-interferon autoantibodies in autoimmune polyendocrinopathy syndrome type 1. PLoS Med. 2006;3:e289 pubmed
- Fauquier T, Rizzoti K, Dattani M, Lovell Badge R, Robinson I. SOX2-expressing progenitor cells generate all of the major cell types in the adult mouse pituitary gland. Proc Natl Acad Sci U S A. 2008;105:2907-12 pubmed publisher..We suggest that this SOX2(+)/SOX9(+) population represents transit-amplifying cells, whereas the SOX2(+)/SOX9(-) cells we identify are multipotent progenitor/stem cells persisting in the adult pituitary. ..
- Frye M, Benitah S. Chromatin regulators in mammalian epidermis. Semin Cell Dev Biol. 2012;23:897-905 pubmed publisher..Here we summarize and discuss emerging roles of chromatin and epigenetic complexes in the mammalian epidermis. ..
- Bevan C, Hoare S, Claessens F, Heery D, Parker M. The AF1 and AF2 domains of the androgen receptor interact with distinct regions of SRC1. Mol Cell Biol. 1999;19:8383-92 pubmed..This recruitment is in direct contrast to the recruitment of SRC1 to the estrogen receptor, which requires interaction with the ligand-binding domain. ..
- Downward J, Leevers S. Trachealess--a new transcription factor target for PKB/Akt. Dev Cell. 2001;1:726-8 pubmed..Applying a combined genetic and biochemical approach has led to the identification of a new protein kinase B/Akt target, the transcription factor Trachealess. ..
- Gillingham A, Pfeifer A, Munro S. CASP, the alternatively spliced product of the gene encoding the CCAAT-displacement protein transcription factor, is a Golgi membrane protein related to giantin. Mol Biol Cell. 2002;13:3761-74 pubmed..The conserved histidine is necessary for Coy1p's activity in cells lacking Gos1p, suggesting that the TMD of these transmembrane Golgi coiled-coil proteins is directly involved in their function. ..
- Phelps M, Darley M, Primrose J, Blaydes J. p53-independent activation of the hdm2-P2 promoter through multiple transcription factor response elements results in elevated hdm2 expression in estrogen receptor alpha-positive breast cancer cells. Cancer Res. 2003;63:2616-23 pubmed..Our findings support the hypothesis that the elevated levels of hdm2 expression reported in cancers such as ERalpha(+ve) breast tumors play an important role in the development of these tumors. ..
- Wheeler G, Trotter E, Dawes I, Grant C. Coupling of the transcriptional regulation of glutathione biosynthesis to the availability of glutathione and methionine via the Met4 and Yap1 transcription factors. J Biol Chem. 2003;278:49920-8 pubmed..These results indicate that the Yap1-dependent activation of GSH1 expression in response to glutathione depletion is regulated by the sulfur status of the cell through a specific Met4-dependent mechanism. ..
- Williams L, Bradley L, Smith A, Foxwell B. Signal transducer and activator of transcription 3 is the dominant mediator of the anti-inflammatory effects of IL-10 in human macrophages. J Immunol. 2004;172:567-76 pubmed..In conclusion, although STAT3 does appear to be the dominant mediator of the majority of IL-10 functions, there are elements of its anti-inflammatory activity that are STAT3 independent. ..
- Bruno M, Flaus A, Stockdale C, Rencurel C, Ferreira H, Owen Hughes T. Histone H2A/H2B dimer exchange by ATP-dependent chromatin remodeling activities. Mol Cell. 2003;12:1599-606 pubmed..This provides eukaryotes with additional means by which they may manipulate chromatin structure. ..
- McWatters H, Kolmos E, Hall A, Doyle M, Amasino R, Gyula P, et al. ELF4 is required for oscillatory properties of the circadian clock. Plant Physiol. 2007;144:391-401 pubmed..ELF4, therefore, can be considered a component of the central CCA1/LHY-TOC1 feedback loop in the plant circadian clock. ..
- Wathes D, Abayasekara D, Aitken R. Polyunsaturated fatty acids in male and female reproduction. Biol Reprod. 2007;77:190-201 pubmed..Adequately powered trials that control for the ratios of different PUFAs consumed are required to determine the extent to which this aspect of our diets does influence our fertility. ..
- Gonzalez D, Bowen A, Carroll T, Conlan R. The transcription corepressor LEUNIG interacts with the histone deacetylase HDA19 and mediator components MED14 (SWP) and CDK8 (HEN3) to repress transcription. Mol Cell Biol. 2007;27:5306-15 pubmed..We suggest that changes in chromatin structure coupled with regulation of Mediator function are likely to be utilized by LEUNIG in the repression of gene transcription. ..
- Jedrusik A, Parfitt D, Guo G, Skamagki M, Grabarek J, Johnson M, et al. Role of Cdx2 and cell polarity in cell allocation and specification of trophectoderm and inner cell mass in the mouse embryo. Genes Dev. 2008;22:2692-706 pubmed publisher..Thus, divisions generating inside and outside cells are truly asymmetric with respect to cell fate instructions. These two interacting effects ensure the generation of a stable outer epithelium by the blastocyst stage...
- Forman J, Worth C, Bickerton G, Eisen T, Blundell T. Structural bioinformatics mutation analysis reveals genotype-phenotype correlations in von Hippel-Lindau disease and suggests molecular mechanisms of tumorigenesis. Proteins. 2009;77:84-96 pubmed publisher..Additionally, predicting effects of genetic variation will be critical as genetic sequencing accelerates; the analytical strategy presented here may elucidate other systems as further data on genetic variation become available. ..
- Strudwick N, Brown M, Parmar V, Schroder M. Ime1 and Ime2 are required for pseudohyphal growth of Saccharomyces cerevisiae on nonfermentable carbon sources. Mol Cell Biol. 2010;30:5514-30 pubmed publisher..Based on these findings, we propose to include exit from pseudohyphal growth and entry into meiosis in the life cycle of S. cerevisiae. ..
- Hattersley N, Shen L, Jaffray E, Hay R. The SUMO protease SENP6 is a direct regulator of PML nuclear bodies. Mol Biol Cell. 2011;22:78-90 pubmed publisher..Mutation of the catalytic cysteine of SENP6 results in its accumulation in PML NBs, and biochemical analysis indicates that SUMO-modified PML is a substrate of SENP6. ..
- Gennet N, Gale E, Nan X, Farley E, Takacs K, Oberwallner B, et al. Doublesex and mab-3-related transcription factor 5 promotes midbrain dopaminergic identity in pluripotent stem cells by enforcing a ventral-medial progenitor fate. Proc Natl Acad Sci U S A. 2011;108:9131-6 pubmed publisher..Together, these data identify Dmrt5 as an important player in ventral mesencephalic neural fate specification. ..
- Cross B, Bond P, Sadowski P, Jha B, Zak J, Goodman J, et al. The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule. Proc Natl Acad Sci U S A. 2012;109:E869-78 pubmed publisher..Thus, the chemical reactivity and sterics of a unique residue in the endonuclease active site of IRE1 can be exploited by selective inhibitors to interfere with protein secretion in pathological settings. ..
- Fish P, Filippakopoulos P, Bish G, Brennan P, Bunnage M, Cook A, et al. Identification of a chemical probe for bromo and extra C-terminal bromodomain inhibition through optimization of a fragment-derived hit. J Med Chem. 2012;55:9831-7 pubmed publisher..This has yielded a potent, selective compound with cell-based activity (PFI-1) that may further add to the understanding of BET family function within the bromodomains. ..
- Carballo J, Panizza S, Serrentino M, Johnson A, Geymonat M, Borde V, et al. Budding yeast ATM/ATR control meiotic double-strand break (DSB) levels by down-regulating Rec114, an essential component of the DSB-machinery. PLoS Genet. 2013;9:e1003545 pubmed publisher..Taken together, we present evidence for three independent ways of regulating Rec114 activity, which likely contribute to meiotic DSBs-homeostasis in maintaining genetically determined levels of breaks. ..
- Smith H, Xu Y, Quail P. Antagonistic but complementary actions of phytochromes A and B allow seedling de-etiolation. Plant Physiol. 1997;114:637-41 pubmed..The antagonistic and complementary actions of phyA and phyB, therefore, allow the optimum regulation of seedling growth after emergence from the soil. ..
- Read E, Rodaway A, Neave B, Brandon N, Holder N, Patient R, et al. Evidence for non-axial A/P patterning in the nonneural ectoderm of Xenopus and zebrafish pregastrula embryos. Int J Dev Biol. 1998;42:763-74 pubmed
- Wilson J, Deed R, Inoue T, Balzi M, Becciolini A, Faraoni P, et al. Expression of Id helix-loop-helix proteins in colorectal adenocarcinoma correlates with p53 expression and mitotic index. Cancer Res. 2001;61:8803-10 pubmed
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