Experts and Doctors on transcription factors in Germany

Summary

Locale: Germany
Topic: transcription factors

Top Publications

  1. Peekhaus N, Tolner B, Poolman B, Kr mer R. The glutamate uptake regulatory protein (Grp) of Zymomonas mobilis and its relation to the global regulator Lrp of Escherichia coli. J Bacteriol. 1995;177:5140-7 pubmed
    ..The expression of grp is autoregulated, and in Z. mobilis, it depends on growth conditions. The putative presence of a homolog of Grp in E. coli is discussed...
  2. Leptin M. Morphogenesis. Control of epithelial cell shape changes. Curr Biol. 1994;4:709-12 pubmed
    ..Cell-shape changes in the gastrulating Drosophila embryo generate two epithelial invaginations. These changes are regulated by four transcription factors, and folded gastrulation is a candidate downstream effector. ..
  3. Bauer R, Imhof A, Pscherer A, Kopp H, Moser M, Seegers S, et al. The genomic structure of the human AP-2 transcription factor. Nucleic Acids Res. 1994;22:1413-20 pubmed
    ..A partial AP-2 promoter fragment including the AP-2 consensus binding site is approximately 5-fold transactivated by cotransfection of an AP-2 expression plasmid. ..
  4. Ludwig A, Tengel C, Bauer S, Bubert A, Benz R, Mollenkopf H, et al. SlyA, a regulatory protein from Salmonella typhimurium, induces a haemolytic and pore-forming protein in Escherichia coli. Mol Gen Genet. 1995;249:474-86 pubmed
    ..slyA- and slyB-related genes were also obtained by PCR from E. coli, Shigella sp. and Citrobacter diversus but not from several other gram-negative bacteria tested. ..
  5. Resch K, Korthaus D, Wedemeyer N, Lengeling A, Ronsiek M, Thiel C, et al. Homology between human chromosome 2p13.3 and the wobbler critical region on mouse chromosome 11: comparative high-resolution mapping of STS and EST loci on YAC/BAC contigs. Mamm Genome. 1998;9:893-8 pubmed
  6. Wolff C, Pepling M, Gergen P, Klingler M. Structure and evolution of a pair-rule interaction element: runt regulatory sequences in D. melanogaster and D. virilis. Mech Dev. 1999;80:87-99 pubmed
  7. Eberharter A, Ferrari S, Langst G, Straub T, Imhof A, Varga Weisz P, et al. Acf1, the largest subunit of CHRAC, regulates ISWI-induced nucleosome remodelling. EMBO J. 2001;20:3781-8 pubmed
    ..Refined analyses now suggest that topoisomerase II should not be considered a stable subunit of CHRAC. Accordingly, CHRAC can be molecularly defined as a complex consisting of ISWI, Acf1, CHRAC-14 and CHRAC-16. ..
  8. Gollner H, Bouwman P, Mangold M, Karis A, Braun H, Rohner I, et al. Complex phenotype of mice homozygous for a null mutation in the Sp4 transcription factor gene. Genes Cells. 2001;6:689-97 pubmed
    ..Thus, the structural similarities, the common recognition motif and the overlapping expression pattern of these three transcription factors do not reflect similar physiological functions. ..
  9. Nagel S, Hambach L, Krauter J, Venturini L, Heidenreich O, Ganser A, et al. Analysis of the nuclear distribution of the translocation t(8;21)-derived fusion protein AML1/ETO by confocal laser scanning microscopy. J Hematother Stem Cell Res. 2002;11:401-8 pubmed
    ..Finally, AML1/ETO could not be co-localized with PML and SUMO-1, indicating that AML1/ETO is not part of the nuclear bodies and probably not SUMOylated. ..

More Information

Publications790 found, 100 shown here

  1. Viereck V, Siggelkow H, Tauber S, Raddatz D, Schutze N, Hufner M. Differential regulation of Cbfa1/Runx2 and osteocalcin gene expression by vitamin-D3, dexamethasone, and local growth factors in primary human osteoblasts. J Cell Biochem. 2002;86:348-56 pubmed
    ..These data imply that Cbfa1 gene expression is differentially regulated by various osteoblastic differentiating agents and is dependent on the stage of maturation. ..
  2. Bossert B, Marozin S, Conzelmann K. Nonstructural proteins NS1 and NS2 of bovine respiratory syncytial virus block activation of interferon regulatory factor 3. J Virol. 2003;77:8661-8 pubmed
    ..NS protein-mediated inhibition of IRF-3 activation and IFN induction should have considerable impact on the pathogenesis and immunogenicity of BRSV. ..
  3. Roth S. The origin of dorsoventral polarity in Drosophila. Philos Trans R Soc Lond B Biol Sci. 2003;358:1317-29; discussion 1329 pubmed
    ..This leads to a nuclear concentration gradient of Dorsal that specifies the cell types along the DV axis of the embryo. ..
  4. Ringseis R, Eder K. Dietary oxidized cholesterol decreases expression of hepatic microsomal triglyceride transfer protein in rats. J Nutr Biochem. 2004;15:103-11 pubmed
    ..In conclusion, the data of this study suggest, that dietary oxidized cholesterol affects VLDL assembly and/or secretion by reducing the synthesis of MTP but not by impairing hepatic lipogenesis or synthesis of apolipoprotein B. ..
  5. Gnügge L, Meyer D, Driever W. Pancreas development in zebrafish. Methods Cell Biol. 2004;76:531-51 pubmed
  6. K ck M, Stenzel I, Zimmer A. Tissue-specific expression of tomato Ribonuclease LX during phosphate starvation-induced root growth. J Exp Bot. 2006;57:3717-26 pubmed publisher
    ..These data indicate that the role of intracellular RNaseLX in the phosphate starvation response is connected with specific RNA turnover processes at the root tip...
  7. Leich E, Haralambieva E, Zettl A, Chott A, Rudiger T, Holler S, et al. Tissue microarray-based screening for chromosomal breakpoints affecting the T-cell receptor gene loci in mature T-cell lymphomas. J Pathol. 2007;213:99-105 pubmed
  8. Hermanns P, Grasberger H, Refetoff S, Pohlenz J. Mutations in the NKX2.5 gene and the PAX8 promoter in a girl with thyroid dysgenesis. J Clin Endocrinol Metab. 2011;96:E977-81 pubmed publisher
    ..Thus, this promoter mutation is expected to lead to reduced PAX8 expression. We identified new heterozygous mutations in both NKX2.5 and PAX8 genes of a girl with TD. Both defects might contribute to the phenotype. ..
  9. Hartl M, Loschek L, Stephan D, Siju K, Knappmeyer C, Kadow I. A new Prospero and microRNA-279 pathway restricts CO2 receptor neuron formation. J Neurosci. 2011;31:15660-73 pubmed publisher
    ..Given the important role of Pros in differentiation of the nervous system, we anticipate that miR-mediated signal tuning represents a powerful method for olfactory sensory system diversification during evolution. ..
  10. Schoofs T, Rohde C, Hebestreit K, Klein H, Göllner S, Schulze I, et al. DNA methylation changes are a late event in acute promyelocytic leukemia and coincide with loss of transcription factor binding. Blood. 2013;121:178-87 pubmed publisher
    ..The results of the present study suggest that aberrant DNA methylation is associated with leukemia phenotype but is not required for PML-RAR?-mediated initiation of leukemogenesis...
  11. Schön M, Töller A, Diezel C, Roth C, Westphal L, Wiermer M, et al. Analyses of wrky18 wrky40 plants reveal critical roles of SA/EDS1 signaling and indole-glucosinolate biosynthesis for Golovinomyces orontii resistance and a loss-of resistance towards Pseudomonas syringae pv. tomato AvrRPS4. Mol Plant Microbe Interact. 2013;26:758-67 pubmed publisher
    ..orontii depends on the function of WRKY18 and WRKY40 to successfully infect Arabidopsis wild-type plants while, in the interaction with P. syringae AvrRPS4, they are required to mediate effector-triggered immunity. ..
  12. Holewa B, Zapp D, Drewes T, Senkel S, Ryffel G. HNF4beta, a new gene of the HNF4 family with distinct activation and expression profiles in oogenesis and embryogenesis of Xenopus laevis. Mol Cell Biol. 1997;17:687-94 pubmed
    ..All of these distinct characteristics of the newly identified HNF4 protein imply that the alpha and beta isoform have different functions in development and in adult tissues. ..
  13. Hennig W. Heterochromatin. Chromosoma. 1999;108:1-9 pubmed
  14. Wodarz A, Ramrath A, Kuchinke U, Knust E. Bazooka provides an apical cue for Inscuteable localization in Drosophila neuroblasts. Nature. 1999;402:544-7 pubmed
    ..As Bazooka is also responsible for the maintenance of apical-basal polarity in epithelial tissues, it may be the missing link between epithelial polarity and neuroblast polarity. ..
  15. Lohrmann J, Sweere U, Zabaleta E, Bäurle I, Keitel C, Kozma Bognar L, et al. The response regulator ARR2: a pollen-specific transcription factor involved in the expression of nuclear genes for components of mitochondrial complex I in Arabidopsis. Mol Genet Genomics. 2001;265:2-13 pubmed
    ..These findings point to an as yet unidentified signal transduction system that may regulate aspects of floral and mitochondrial gene expression. ..
  16. Kölsch V, Paululat A. The highly conserved cardiogenic bHLH factor Hand is specifically expressed in circular visceral muscle progenitor cells and in all cell types of the dorsal vessel during Drosophila embryogenesis. Dev Genes Evol. 2002;212:473-85 pubmed
    ..In many aspects the expression pattern of Drosophila hand resembles the patterns of its vertebrates orthologues, for instance in cardiac tissues. We assume that Hand proteins might play a highly conserved role throughout evolution. ..
  17. Zhao H, Cao Y, Grunz H. Xenopus X-box binding protein 1, a leucine zipper transcription factor, is involved in the BMP signaling pathway. Dev Biol. 2003;257:278-91 pubmed
    ..Taken together, the results suggest a role for XXBP-1 in the control of neural differentiation, possibly as an activator. ..
  18. Xu G, Muller O, Stange E, Fuchs M. Impaired regulation of sterol regulatory element binding protein 2 in cholesterol gallstone-susceptible mice. Biochim Biophys Acta. 2004;1688:274-9 pubmed
    ..This defect may contribute to cholesterol hypersecretion and gallstone formation. ..
  19. Kues W, Petersen B, Mysegades W, Carnwath J, Niemann H. Isolation of murine and porcine fetal stem cells from somatic tissue. Biol Reprod. 2005;72:1020-8 pubmed
    ..We report that fetal tissue contains somatic stem cells with greater potency than previously thought, which might form a new source of stem cells useful in somatic nuclear transfer and cell therapy. ..
  20. Mathas S, Johrens K, Joos S, Lietz A, Hummel F, Janz M, et al. Elevated NF-kappaB p50 complex formation and Bcl-3 expression in classical Hodgkin, anaplastic large-cell, and other peripheral T-cell lymphomas. Blood. 2005;106:4287-93 pubmed
    ..Together, these data suggest that elevated Bcl-3 expression has an important function in cHL and peripheral T-NHL, in particular ALCL. ..
  21. Karcher C, Fischer A, Schweickert A, Bitzer E, Horie S, Witzgall R, et al. Lack of a laterality phenotype in Pkd1 knock-out embryos correlates with absence of polycystin-1 in nodal cilia. Differentiation. 2005;73:425-32 pubmed publisher
    ..Our results demonstrate a PC1-independent function of PC2 in left-right axis formation, and indirectly support a ciliary role of PC2 in this process...
  22. Mettler U, Vogler G, Urban J. Timing of identity: spatiotemporal regulation of hunchback in neuroblast lineages of Drosophila by Seven-up and Prospero. Development. 2006;133:429-37 pubmed
    ..Strikingly, although the complete downregulation of hb is mitosis dependent, the lineage-specific timing of svp upregulation is not. ..
  23. Lenz B, Bleich S, Beutler S, Schlierf B, Schwager K, Reulbach U, et al. Homocysteine regulates expression of Herp by DNA methylation involving the AARE and CREB binding sites. Exp Cell Res. 2006;312:4049-55 pubmed
    ..Complete methylation of the CpG islands resulted in suppressed gene expression. ..
  24. Ruiz P, Braune A, Hölzlwimmer G, Quintanilla Fend L, Haller D. Quercetin inhibits TNF-induced NF-kappaB transcription factor recruitment to proinflammatory gene promoters in murine intestinal epithelial cells. J Nutr. 2007;137:1208-15 pubmed
    ..These studies support an anti-inflammatory effect of quercetin in epithelial cells through mechanisms that inhibit cofactor recruitment at the chromatin of proinflammatory genes. ..
  25. Schroeder P, Pohl C, Calles C, Marks C, Wild S, Krutmann J. Cellular response to infrared radiation involves retrograde mitochondrial signaling. Free Radic Biol Med. 2007;43:128-35 pubmed
    ..Thus, IRA, in contrast to UV, elicits a retrograde signaling response in human skin. ..
  26. Schlicht R, Winkler G. A delay stochastic process with applications in molecular biology. J Math Biol. 2008;57:613-48 pubmed publisher
    ..Simulation of the molecular oscillator controlling this process reveals major differences between stochastic and deterministic models. ..
  27. Wagner D, Schmeinck A, Mos M, Morozov I, Caddick M, Tudzynski B. The bZIP transcription factor MeaB mediates nitrogen metabolite repression at specific loci. Eukaryot Cell. 2010;9:1588-601 pubmed publisher
    ..These data demonstrate that MeaB and AreA coordinately mediate nitrogen metabolite repression and, importantly, that independently of AreA, MeaB can mediate nitrogen metabolite repression at specific loci in F. fujikuroi. ..
  28. Vasilevski A, Giorgi F, Bertinetti L, Usadel B. LASSO modeling of the Arabidopsis thaliana seed/seedling transcriptome: a model case for detection of novel mucilage and pectin metabolism genes. Mol Biosyst. 2012;8:2566-74 pubmed publisher
    ..We show that a loss of function of this putative transcription factor leads to a significant decrease in mucilage pectin. ..
  29. Wild R, Gerasimaite R, Jung J, Truffault V, Pavlovic I, Schmidt A, et al. Control of eukaryotic phosphate homeostasis by inositol polyphosphate sensor domains. Science. 2016;352:986-90 pubmed publisher
    ..We propose that InsPs communicate cytosolic P(i) levels to SPX domains and enable them to interact with a multitude of proteins to regulate P(i) uptake, transport, and storage in fungi, plants, and animals. ..
  30. Mishra V, Wegwitz F, Kosinsky R, Sen M, Baumgartner R, Wulff T, et al. Histone deacetylase class-I inhibition promotes epithelial gene expression in pancreatic cancer cells in a BRD4- and MYC-dependent manner. Nucleic Acids Res. 2017;45:6334-6349 pubmed publisher
    ..Taken together, our study uncovers a previously unknown role of BRD4 and MYC in eliciting the HDACi-mediated induction of a subset of genes and provides molecular insight into the mechanisms of HDACi action in PDAC. ..
  31. Jelkmann W, Pagel H, Hellwig T, Fandrey J. Effects of antioxidant vitamins on renal and hepatic erythropoietin production. Kidney Int. 1997;51:497-501 pubmed
    ..Preliminary evidence suggests that this effect of vitamin A involves increased mRNA levels of hypoxia-inducible factor 1 alpha (HIF-1 alpha). ..
  32. Lehmann M, Wattler F, Korge G. Two new regulatory elements controlling the Drosophila Sgs-3 gene are potential ecdysone receptor and fork head binding sites. Mech Dev. 1997;62:15-27 pubmed
    ..Since also the Sgs-4 gene is controlled by a functional EcR/USP binding site, a direct participation of EcR/USP in the formation of regulatory complexes may be of general importance for the hormonal control of Sgs genes. ..
  33. Zhu C, Yamada G, Nakamura S, Terashi T, Schweickert A, Blum M. Malformation of trachea and pelvic region in goosecoid mutant mice. Dev Dyn. 1998;211:374-81 pubmed
    ..In addition, we discuss evidence for the existence of at least three goosecoid genes in vertebrates, which may account for the lack of a defect of axial patterning in goosecoid mutant mice. ..
  34. Corona D, Eberharter A, Budde A, Deuring R, Ferrari S, Varga Weisz P, et al. Two histone fold proteins, CHRAC-14 and CHRAC-16, are developmentally regulated subunits of chromatin accessibility complex (CHRAC). EMBO J. 2000;19:3049-59 pubmed
    ..The developmental expression profiles of both subunits suggest specialized roles in chromatin remodelling reactions in the early embryo for both histone fold subunits. ..
  35. Remenyi A, Tomilin A, Pohl E, Lins K, Philippsen A, Reinbold R, et al. Differential dimer activities of the transcription factor Oct-1 by DNA-induced interface swapping. Mol Cell. 2001;8:569-80 pubmed
    ..We suggest interface swapping in dimers could be a general mechanism of modulating the activity of transcription factors. ..
  36. Hamer O, Forstner D, Ottinger I, Ristow M, Bollheimer L, Scholmerich J, et al. The Pro115Gln polymorphism within the PPAR gamma2 gene has no epidemiological impact on morbid obesity. Exp Clin Endocrinol Diabetes. 2002;110:230-4 pubmed
    ..It needs further investigation whether this polymorphism might play a role in related metabolic disorders. ..
  37. Ruscher K, Freyer D, Karsch M, Isaev N, Megow D, Sawitzki B, et al. Erythropoietin is a paracrine mediator of ischemic tolerance in the brain: evidence from an in vitro model. J Neurosci. 2002;22:10291-301 pubmed
    ..PI3K deactivates BAD via Akt-mediated phosphorylation and thus may inhibit hypoxia-induced apoptosis in neurons. Our results establish EPO as an important paracrine neuroprotective mediator of ischemic preconditioning. ..
  38. Young J, Hartl F. A stress sensor for the bacterial periplasm. Cell. 2003;113:1-2 pubmed
    ..This interaction relieves the inhibition of the neighboring protease domain of DegS, triggering a proteolysis cascade that leads to the sigma(E)-driven expression of periplasmic chaperones...
  39. Heim M, Jakoby M, Werber M, Martin C, Weisshaar B, Bailey P. The basic helix-loop-helix transcription factor family in plants: a genome-wide study of protein structure and functional diversity. Mol Biol Evol. 2003;20:735-47 pubmed
    ..Based on the current characterization of a limited number of plant bHLH proteins, we predict that this family of TFs has a range of different roles in plant cell and tissue development as well as plant metabolism. ..
  40. Kokubu C, Wilm B, Kokubu T, Wahl M, Rodrigo I, Sakai N, et al. Undulated short-tail deletion mutation in the mouse ablates Pax1 and leads to ectopic activation of neighboring Nkx2-2 in domains that normally express Pax1. Genetics. 2003;165:299-307 pubmed
    ..Taken together, we propose that a combination of a loss-of-function mutation of Pax1 and a gain-of-function mutation of Nkx2-2 is the molecular basis of the Pax1(Un-s) mutation. ..
  41. Graw J. Congenital hereditary cataracts. Int J Dev Biol. 2004;48:1031-44 pubmed
  42. Hellwig Burgel T, Stiehl D, Katschinski D, Marxsen J, Kreft B, Jelkmann W. VEGF production by primary human renal proximal tubular cells: requirement of HIF-1, PI3-kinase and MAPKK-1 signaling. Cell Physiol Biochem. 2005;15:99-108 pubmed
    ..Furthermore, hypoxia alone was sufficient to activate PI3K in PTEC in contrast to MAPKK-1, whose activity was lowered in hypoxia. ..
  43. Gigolashvili T, Berger B, Mock H, Muller C, Weisshaar B, Flügge U. The transcription factor HIG1/MYB51 regulates indolic glucosinolate biosynthesis in Arabidopsis thaliana. Plant J. 2007;50:886-901 pubmed
    ..We hypothesize that HIG1/MYB51 is a regulator of indolic glucosinolate biosynthesis that also controls responses to biotic challenges. ..
  44. Dabas N, Morschh user J. A transcription factor regulatory cascade controls secreted aspartic protease expression in Candida albicans. Mol Microbiol. 2008;69:586-602 pubmed publisher
    ..albicans, is controlled by a regulatory cascade in which the general regulators Gln3p and Gat1p control the expression of the transcription factor Stp1p, which in turn mediates SAP2 expression...
  45. Licausi F, Weits D, Pant B, Scheible W, Geigenberger P, van Dongen J. Hypoxia responsive gene expression is mediated by various subsets of transcription factors and miRNAs that are determined by the actual oxygen availability. New Phytol. 2011;190:442-56 pubmed publisher
    ..Under anoxic conditions, an additional set of TFs is induced. Regulation of gene expression via miRNAs appears to play a minor role during hypoxia. ..
  46. Lam K, Mühlpfordt F, Vaquerizas J, Raja S, Holz H, Luscombe N, et al. The NSL complex regulates housekeeping genes in Drosophila. PLoS Genet. 2012;8:e1002736 pubmed publisher
    ..Taken together, our findings show that the MOF-containing NSL complex acts as a major regulator of housekeeping genes in flies by modulating initiation of Pol II transcription. ..
  47. Lim S, Becker A, Zimmer A, Lu J, Buettner R, Kirfel J. SNAI1-mediated epithelial-mesenchymal transition confers chemoresistance and cellular plasticity by regulating genes involved in cell death and stem cell maintenance. PLoS ONE. 2013;8:e66558 pubmed publisher
    ..In summary, our data provide new molecular findings how EMT contributes to the enhanced chemoresistance and the acquisition of stem/progenitor-like character by regulating signaling pathways. ..
  48. Ruf V, Holzem C, Peyman T, Walz G, Blackwell T, Neumann Haefelin E. TORC2 signaling antagonizes SKN-1 to induce C. elegans mesendodermal embryonic development. Dev Biol. 2013;384:214-27 pubmed publisher
    ..The SGK-1 kinase mediated these functions downstream of rict-1/TORC2, as a sgk-1 gain-of-function mutant suppressed the rict-1 mutant phenotype. These data indicate that TORC2 and SGK-1 antagonize SKN-1 during embryonic development...
  49. Kim S, Lim K, Kwak T, Lee S, Im J, Hali S, et al. Induced neural stem cells from distinct genetic backgrounds exhibit different reprogramming status. Stem Cell Res. 2016;16:460-8 pubmed publisher
    ..Therefore, our data suggest that the genetic background of starting cells influences the conversion efficiency as well as reprogramming status of directly converted iNSCs. ..
  50. Koritschoner N, Madruga J, Knespel S, Blendinger G, Anzinger B, Otto A, et al. The nuclear orphan receptor TR4 promotes proliferation of myeloid progenitor cells. Cell Growth Differ. 2001;12:563-72 pubmed
    ..In conclusion, these data position the orphan receptor TR4 as an important regulator of myeloid progenitor cell proliferation and development...
  51. Martin B, Kleiber K, Wixler V, Raab M, Zimmer B, Kaufmann M, et al. FHL2 regulates cell cycle-dependent and doxorubicin-induced p21Cip1/Waf1 expression in breast cancer cells. Cell Cycle. 2007;6:1779-88 pubmed
  52. Wehrenberg U, Ivell R, Walther N. The COUP transcription factor (COUP-TF) is directly involved in the regulation of oxytocin gene expression in luteinizing bovine granulosa cells. Biochem Biophys Res Commun. 1992;189:496-503 pubmed
    ..These experimental results from in vitro and in vivo studies point to the direct involvement of COUP-TF in oxytocin gene down-regulation during luteinization of bovine granulosa cells. ..
  53. Drapal N, Sawers G. Promoter 7 of the Escherichia coli pfl operon is a major determinant in the anaerobic regulation of expression by ArcA. J Bacteriol. 1995;177:5338-41 pubmed
    ..In this study, we show that in its normal context the activity of P7 is constrained and that one important function of the promoter is to mediate controlled ArcA-dependent regulation of the operon. ..
  54. Sommer R, Tautz D. Expression patterns of twist and snail in Tribolium (Coleoptera) suggest a homologous formation of mesoderm in long and short germ band insects. Dev Genet. 1994;15:32-7 pubmed
    ..This suggests that the expression of the two genes is required for mesoderm formation both at early blastoderm stage and during germband elongation until the end of the segmental growth process. ..
  55. Zwilling S, Annweiler A, Wirth T. The POU domains of the Oct1 and Oct2 transcription factors mediate specific interaction with TBP. Nucleic Acids Res. 1994;22:1655-62 pubmed
    ..Co-transfection of human TBP and Oct2 expression vectors into B cells resulted in a synergistic activation of an octamer motif containing promoter. ..
  56. Schnieders F, Dork T, Arnemann J, Vogel T, Werner M, Schmidtke J. Testis-specific protein, Y-encoded (TSPY) expression in testicular tissues. Hum Mol Genet. 1996;5:1801-7 pubmed
    ..The data presented here point to a phosphorylation-dependent TSPY-function in early spermatogenesis, immediately prior to the spermatogonia-to-spermatocyte transition, and in early testicular tumorigenesis. ..
  57. Lüer K, Urban J, Klämbt C, Technau G. Induction of identified mesodermal cells by CNS midline progenitors in Drosophila. Development. 1997;124:2681-90 pubmed
    ..Thus, the Drosophila CNS midline cells play a central inductive role in patterning the mesoderm as well as the underlying ectoderm. ..
  58. Gregory P, Hörz W. Chromatin and transcription--how transcription factors battle with a repressive chromatin environment. Eur J Biochem. 1998;251:9-18 pubmed
    ..These data provide the latest and potentially most significant demonstration of the importance of the nucleosome in the regulation of transcription. ..
  59. Re D, MUSCHEN M, Ahmadi T, Wickenhauser C, Staratschek Jox A, Holtick U, et al. Oct-2 and Bob-1 deficiency in Hodgkin and Reed Sternberg cells. Cancer Res. 2001;61:2080-4 pubmed
    ..Lack of Oct-2 and Bob-1 points to a defect in transcription machinery in H-RS cells and is associated with lack of immunoglobulin gene expression in these cells...
  60. Kzhyshkowska J, Rusch A, Wolf H, Dobner T. Regulation of transcription by the heterogeneous nuclear ribonucleoprotein E1B-AP5 is mediated by complex formation with the novel bromodomain-containing protein BRD7. Biochem J. 2003;371:385-93 pubmed
    ..We conclude that complex formation between BRD7 and E1B-AP5 links chromatin events with mRNA processing at the level of transcriptional regulation. ..
  61. Otto F, Lubbert M, Stock M. Upstream and downstream targets of RUNX proteins. J Cell Biochem. 2003;89:9-18 pubmed
    ..Whether a particular RUNX protein specifically targets a defined subset of downstream genes or whether there is some redundancy as to which RUNX protein activates which target promoter remains to be elucidated. ..
  62. Behrends U, Schneider I, Rössler S, Frauenknecht H, Golbeck A, Lechner B, et al. Novel tumor antigens identified by autologous antibody screening of childhood medulloblastoma cDNA libraries. Int J Cancer. 2003;106:244-51 pubmed
    ..These findings indicate that the humoral immune response against medulloblastoma is directed against diverse antigens that may be useful as diagnostic markers or targets for immunotherapy. ..
  63. Tenbrock K, Kyttaris V, Ahlmann M, Ehrchen J, Tolnay M, Melkonyan H, et al. The cyclic AMP response element modulator regulates transcription of the TCR zeta-chain. J Immunol. 2005;175:5975-80 pubmed
    ..Our studies demonstrate that CREM alpha binds to the TCR zeta promoter and repress its activity. ..
  64. Kellerer S, Schreiner S, Stolt C, Scholz S, Bösl M, Wegner M. Replacement of the Sox10 transcription factor by Sox8 reveals incomplete functional equivalence. Development. 2006;133:2875-86 pubmed
    ..We conclude that the extent of functional equivalence depends on the tissue and that, despite their relatedness, Sox8 and Sox10 have more unique functions than previously appreciated. ..
  65. Tanaka T, Wiesener M, Bernhardt W, Eckardt K, Warnecke C. The human HIF (hypoxia-inducible factor)-3alpha gene is a HIF-1 target gene and may modulate hypoxic gene induction. Biochem J. 2009;424:143-51 pubmed publisher
    ..These findings shed light on a novel aspect of HIF-3alpha as a HIF-1 target gene and point to a possible role as a modulator of hypoxic gene induction. ..
  66. Coutandin D, Ou H, Lohr F, Dötsch V. Tracing the protectors path from the germ line to the genome. Proc Natl Acad Sci U S A. 2010;107:15318-25 pubmed publisher
    ..This suggests that p53 is the most recent evolutionary member of this protein family and predicts a mechanism for p53 activation. ..
  67. Schormair B, Plag J, Kaffe M, Gross N, Czamara D, Samtleben W, et al. MEIS1 and BTBD9: genetic association with restless leg syndrome in end stage renal disease. J Med Genet. 2011;48:462-6 pubmed publisher
    ..0013, OR 1.47). This is the first demonstration of a genetic influence on RLS in ESRD patients with BTBD9 being significantly associated. The extent of the genetic predisposition could vary between different subgroups of RLS in ESRD. ..
  68. Worbs M, Bourenkov G, Bartunik H, Huber R, Wahl M. An extended RNA binding surface through arrayed S1 and KH domains in transcription factor NusA. Mol Cell. 2001;7:1177-89 pubmed
    ..Structural and mutational analyses indicate that the motifs cooperate, modulating strength and specificity of RNA binding...
  69. Kuhn H, Liebers U, Gessner C, Schumacher A, Witt C, Schauer J, et al. Adenovirus-mediated E2F-1 gene transfer in nonsmall-cell lung cancer induces cell growth arrest and apoptosis. Eur Respir J. 2002;20:703-9 pubmed
    ..Moreover, treatment of implanted tumours in SCID mice with AdE2F inhibited tumour growth. These data suggest that adenovirus-mediated E2F-1 gene therapy may be effective in the treatment of nonsmall-cell lung cancer. ..
  70. Roguev A, Schaft D, Shevchenko A, Aasland R, Shevchenko A, Stewart A. High conservation of the Set1/Rad6 axis of histone 3 lysine 4 methylation in budding and fission yeasts. J Biol Chem. 2003;278:8487-93 pubmed
    ..Thus, we infer that Set1C is highly conserved in eukaryotes but observe that its links to the proteome are not. ..
  71. Dotzlaw H, Papaioannou M, Moehren U, Claessens F, Baniahmad A. Agonist-antagonist induced coactivator and corepressor interplay on the human androgen receptor. Mol Cell Endocrinol. 2003;213:79-85 pubmed
    ..This may indicate that coactivators and corepressors act in concert to dictate the overall receptor-mediated action dependent on the type of ligand. ..
  72. Knerr I, Schubert S, Wich C, Amann K, Aigner T, Vogler T, et al. Stimulation of GCMa and syncytin via cAMP mediated PKA signaling in human trophoblastic cells under normoxic and hypoxic conditions. FEBS Lett. 2005;579:3991-8 pubmed
    ..We propose that GCMa-driven syncytin expression is the key mechanism for syncytiotrophoblast formation. ..
  73. Forster N, Gallinat S, Jablonska J, Weiss S, Elsässer H, Lutz W. p300 protein acetyltransferase activity suppresses systemic lupus erythematosus-like autoimmune disease in mice. J Immunol. 2007;178:6941-8 pubmed
    ..These findings support the concept of treating lupus with inhibitors of protein deacetylases and point to B cells as a critical target of these drugs...
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