Experts and Doctors on transaminases in United States

Summary

Locale: United States
Topic: transaminases

Top Publications

  1. Koenigsknecht M, Fenlon L, Downs D. Phosphoribosylpyrophosphate synthetase (PrsA) variants alter cellular pools of ribose 5-phosphate and influence thiamine synthesis in Salmonella enterica. Microbiology. 2010;156:950-9 pubmed publisher
    ..These results emphasize the balance that must be reached between pathways competing for the same substrate to maintain robustness of the metabolic network. ..
  2. Romo A, Liu H. Mechanisms and structures of vitamin B(6)-dependent enzymes involved in deoxy sugar biosynthesis. Biochim Biophys Acta. 2011;1814:1534-47 pubmed publisher
    ..This article is part of a Special Issue entitled: Pyridoxal Phosphate Enzymology. ..
  3. Cai Z, Christianson A, Ståhle L, Keisu M. Reexamining transaminase elevation in Phase I clinical trials: the importance of baseline and change from baseline. Eur J Clin Pharmacol. 2009;65:1025-35 pubmed publisher
    ..Baseline level and changes from baseline in transaminase are important variables to examine in addition to elevation above ULN for more reliably interpreting liver signals in Phase I clinical trials. ..
  4. Dunn P. The importance of green chemistry in process research and development. Chem Soc Rev. 2012;41:1452-61 pubmed publisher
    ..Finally a rosuvastatin (Crestor®) intermediate is produced using a deoxy ribose aldolase (DERA) enzyme in which two carbon-carbon bonds and two chiral centres are formed in the same process step. ..
  5. von Montfort C, Beier J, Guo L, Kaiser J, Arteel G. Contribution of the sympathetic hormone epinephrine to the sensitizing effect of ethanol on LPS-induced liver damage in mice. Am J Physiol Gastrointest Liver Physiol. 2008;294:G1227-34 pubmed publisher
    ..These results also suggest that sympathetic tone may contribute to the initiation and progression of alcoholic liver disease. ..
  6. Chi X, Pahari P, Nonaka K, Van Lanen S. Biosynthetic origin and mechanism of formation of the aminoribosyl moiety of peptidyl nucleoside antibiotics. J Am Chem Soc. 2011;133:14452-9 pubmed publisher
  7. Santiago B, Macgilvray M, Faustoferri R, Quivey R. The branched-chain amino acid aminotransferase encoded by ilvE is involved in acid tolerance in Streptococcus mutans. J Bacteriol. 2012;194:2010-9 pubmed publisher
    ..Collectively, the results of this investigation show that amino acid metabolism is a component of the acid-adaptive repertoire of S. mutans. ..
  8. Zachman Brockmeyer T, Thoden J, Holden H. The structure of RbmB from Streptomyces ribosidificus, an aminotransferase involved in the biosynthesis of ribostamycin. Protein Sci. 2017;26:1886-1892 pubmed publisher
    ..Given the fact that the 2-DOS unit is widespread amongst aminoglycoside antibiotics, the data presented herein provide new molecular insight into the biosynthesis of these sugar-based drugs. ..
  9. Ungprasert P, Crowson C, Simonetto D, Matteson E. Clinical Characteristics and Outcome of Hepatic Sarcoidosis: A Population-Based Study 1976-2013. Am J Gastroenterol. 2017;112:1556-1563 pubmed publisher
    ..Generalizability of the observations to other populations may be limited, as the studied population was predominantly Caucasian. The prevalence of liver disease may be higher in more diverse populations. ..

More Information

Publications68

  1. Hoppe B, Beck B, Milliner D. The primary hyperoxalurias. Kidney Int. 2009;75:1264-1271 pubmed publisher
    ..Promising areas of investigation are being identified. Knowledge of the spectrum of disease expression, early diagnosis, and initiation of treatment before renal failure are essential to realize a benefit for patients. ..
  2. Leavitt J, Tong A, Tong J, Pattie J, Alper H. Coordinated transcription factor and promoter engineering to establish strong expression elements in Saccharomyces cerevisiae. Biotechnol J. 2016;11:866-76 pubmed publisher
    ..This work further highlights the potential of using endogenous transcription factors (including mutant factors) along with hybrid promoters to expand the yeast synthetic biology toolbox. ..
  3. Cook P, Carney A, Holden H. Accommodation of GDP-linked sugars in the active site of GDP-perosamine synthase. Biochemistry. 2008;47:10685-93 pubmed publisher
  4. Burgie E, Holden H. Molecular architecture of DesI: a key enzyme in the biosynthesis of desosamine. Biochemistry. 2007;46:8999-9006 pubmed
    ..Indeed, the nearly 180 degrees difference in hexose orientation explains the equatorial versus axial amino transfer exhibited by DesI and PseC, respectively. ..
  5. Bayard M, Holt J, Boroughs E. Nonalcoholic fatty liver disease. Am Fam Physician. 2006;73:1961-8 pubmed
    ..Medications used to treat insulin resistance, hyperlipidemia, and obesity have been shown to improve transaminase levels, steatosis, and histologic findings. However, no treatments have been shown to affect patient-oriented outcomes. ..
  6. Rabaglia M, Gray Keller M, Frey B, Shortreed M, Smith L, Attie A. Alpha-Ketoisocaproate-induced hypersecretion of insulin by islets from diabetes-susceptible mice. Am J Physiol Endocrinol Metab. 2005;289:E218-24 pubmed
    ..However, succinate does not stimulate insulin secretion in mouse islets. Our data suggest that alpha-ketoglutarate may directly stimulate insulin secretion and that increased formation of alpha-ketoglutarate leads to hyperinsulinemia. ..
  7. Pieracci E, Evert N, Drexler N, Mayes B, Vilcins I, Huang P, et al. Fatal Flea-Borne Typhus in Texas: A Retrospective Case Series, 1985-2015. Am J Trop Med Hyg. 2017;96:1088-1093 pubmed publisher
    ..Flea-borne typhus should be considered in febrile patients with animal or flea exposure and respiratory or neurologic symptoms of unknown etiology. ..
  8. Zmarowski A, Wu H, Brooks J, Potter M, Pellicciari R, Schwarcz R, et al. Astrocyte-derived kynurenic acid modulates basal and evoked cortical acetylcholine release. Eur J Neurosci. 2009;29:529-38 pubmed publisher
  9. Yin X, McPhail K, Kim K, Zabriskie T. Formation of the nonproteinogenic amino acid 2S,3R-capreomycidine by VioD from the viomycin biosynthesis pathway. Chembiochem. 2004;5:1278-81 pubmed
  10. Quiñones B, Swimley M, Taylor A, Dawson E. Identification of Escherichia coli O157 by using a novel colorimetric detection method with DNA microarrays. Foodborne Pathog Dis. 2011;8:705-11 pubmed publisher
    ..coli O157 detection was 100-1000 CFU/mL. Thus, the use of DNA microarrays in combination with photopolymerization allowed the rapid and accurate genotyping of E. coli O157 strains. ..
  11. Cook P, Holden H. A structural study of GDP-4-keto-6-deoxy-D-mannose-3-dehydratase: caught in the act of geminal diamine formation. Biochemistry. 2007;46:14215-24 pubmed
    ..Functional assays further demonstrate that this mutant form of ColD cannot catalyze the dehydration reaction. ..
  12. Smith A, Jameson G, Dos Santos P, Agar J, Naik S, Krebs C, et al. NifS-mediated assembly of [4Fe-4S] clusters in the N- and C-terminal domains of the NifU scaffold protein. Biochemistry. 2005;44:12955-69 pubmed
    ..The assembly and transfer of clusters on NifU are compared with results reported for U- and Nfu-type scaffold proteins, and the need for two functional Fe-S cluster scaffolding domains on NifU is discussed. ..
  13. Ju J, Ozanick S, Shen B, Thomas M. Conversion of (2S)-arginine to (2S,3R)-capreomycidine by VioC and VioD from the viomycin biosynthetic pathway of Streptomyces sp. strain ATCC11861. Chembiochem. 2004;5:1281-5 pubmed
  14. Chistoserdova L, Lidstrom M. Cloning, mutagenesis, and physiological effect of a hydroxypyruvate reductase gene from Methylobacterium extorquens AM1. J Bacteriol. 1992;174:71-7 pubmed
    ..The gene encoding hydroxypyruvate reductase was shown to be located about 3 kb upstream of two other serine cycles genes encoding phosphoenolpyruvate carboxylase and malyl coenzyme A lyase. ..
  15. Senger R, Papoutsakis E. Genome-scale model for Clostridium acetobutylicum: Part II. Development of specific proton flux states and numerically determined sub-systems. Biotechnol Bioeng. 2008;101:1053-71 pubmed publisher
    ..These results were then used to establish additional constraints for the genome-scale model. ..
  16. Hanson A, Gregory J. Synthesis and turnover of folates in plants. Curr Opin Plant Biol. 2002;5:244-9 pubmed
    ..Moreover, new analytical advances will help to elucidate plant folate turnover and transport, which are practically unexplored. ..
  17. Ding M, Butler C, Saracco S, Fox T, Godard F, di Rago J, et al. Introduction of cytochrome b mutations in Saccharomyces cerevisiae by a method that allows selection for both functional and non-functional cytochrome b proteins. Biochim Biophys Acta. 2008;1777:1147-56 pubmed publisher
    ..This is the first time mutations have been created for three of the loci presented here, and nine of the resulting mutants have never been described before. ..
  18. Patlolla A, McGinnis B, Tchounwou P. Biochemical and histopathological evaluation of functionalized single-walled carbon nanotubes in Swiss-Webster mice. J Appl Toxicol. 2011;31:75-83 pubmed publisher
    ..However, more studies to clarify the role of functionalization in the in vivo toxicity of SWCNTs are required and parallel comparison is preferred. ..
  19. Jacob M, Shi X, An B, Nagaraja T, Bai J. Evaluation of a multiplex real-time polymerase chain reaction for the quantification of Escherichia coli O157 in cattle feces. Foodborne Pathog Dis. 2012;9:79-85 pubmed publisher
    ..coli O157 in cattle feces using stx1, stx2, and rfbE gene targets may have use in detecting and quantifying super shedders, but is not applicable for quantification in animals shedding low concentrations (10(2) to 10(3) CFU/g feces). ..
  20. Bonner C, Jensen R, Gander J, Keyhani N. A core catalytic domain of the TyrA protein family: arogenate dehydrogenase from Synechocystis. Biochem J. 2004;382:279-91 pubmed
    ..Comparative enzymology established that both of the arogenate-pathway enzymes, prephenate aminotransferase and TyrA(a), were present in many diverse cyanobacteria and in a variety of eukaryotic red and green algae. ..
  21. Maloney G, Kochevenko A, Tieman D, Tohge T, Krieger U, Zamir D, et al. Characterization of the branched-chain amino acid aminotransferase enzyme family in tomato. Plant Physiol. 2010;153:925-36 pubmed publisher
    ..Together, these results support a model in which the mitochondrial SlBCAT1 and -2 function in BCAA catabolism while the chloroplastic SlBCAT3 and -4 function in BCAA synthesis. ..
  22. McGoon M, Frost A, Oudiz R, Badesch D, Galie N, Olschewski H, et al. Ambrisentan therapy in patients with pulmonary arterial hypertension who discontinued bosentan or sitaxsentan due to liver function test abnormalities. Chest. 2009;135:122-129 pubmed publisher
    ..Ambrisentan treatment may be an option for patients who have discontinued bosentan and/or sitaxsentan therapy due to LFT result abnormalities. Clinicaltrials.gov Identifier NCT00423592. ..
  23. Thoden J, Schäffer C, Messner P, Holden H. Structural analysis of QdtB, an aminotransferase required for the biosynthesis of dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose. Biochemistry. 2009;48:1553-61 pubmed publisher
    ..This investigation represents the first structural analysis of a sugar-modifying aminotransferase with a bound product in its active site that functions at the C-3' rather than the C-4' position of the hexose...
  24. Hattori A, Tsunoda M, Konuma T, Kobayashi M, Nagy T, Glushka J, et al. Cancer progression by reprogrammed BCAA metabolism in myeloid leukaemia. Nature. 2017;545:500-504 pubmed publisher
    ..Taken together, this work reveals that altered BCAA metabolism activated through the MSI2-BCAT1 axis drives cancer progression in myeloid leukaemia. ..
  25. Schmitz G, Downs D. Reduced transaminase B (IlvE) activity caused by the lack of yjgF is dependent on the status of threonine deaminase (IlvA) in Salmonella enterica serovar Typhimurium. J Bacteriol. 2004;186:803-10 pubmed
    ..Based on work described here and structural reports in the literature, we suggest a working model in which YjgF has a role in protecting the cell from toxic effects of imbalanced ketoacid pools. ..
  26. Christopherson M, Schmitz G, Downs D. YjgF is required for isoleucine biosynthesis when Salmonella enterica is grown on pyruvate medium. J Bacteriol. 2008;190:3057-62 pubmed publisher
    ..From this study, we conclude that the isoleucine requirement of a yjgF mutant on pyruvate is a consequence of the decreased transaminase B (IlvE) activity that has previously been characterized in these mutants. ..
  27. Van Lanen S, Lin S, Shen B. Biosynthesis of the enediyne antitumor antibiotic C-1027 involves a new branching point in chorismate metabolism. Proc Natl Acad Sci U S A. 2008;105:494-9 pubmed publisher
    ..The net conversion of chorismate to OPA by the tandem action of SgcD and SgcG unambiguously establishes a new branching point in chorismate metabolism. ..
  28. De Crecy Lagard V, El Yacoubi B, de la Garza R, Noiriel A, Hanson A. Comparative genomics of bacterial and plant folate synthesis and salvage: predictions and validations. BMC Genomics. 2007;8:245 pubmed
    ..More generally, our data indicate how combined genomic analysis of both plants and prokaryotes can be more powerful than isolated examination of either group alone. ..
  29. Burgie E, Thoden J, Holden H. Molecular architecture of DesV from Streptomyces venezuelae: a PLP-dependent transaminase involved in the biosynthesis of the unusual sugar desosamine. Protein Sci. 2007;16:887-96 pubmed
    ..In the case of PseC, however, the amino group is transferred to the C-4 rather than the C-3 position. Details concerning the structural analysis of DesV and a comparison of its molecular architecture to that of PseC are presented. ..
  30. O Toole G, Trzebiatowski J, Escalante Semerena J. The cobC gene of Salmonella typhimurium codes for a novel phosphatase involved in the assembly of the nucleotide loop of cobalamin. J Biol Chem. 1994;269:26503-11 pubmed
    ..We propose that cobC codes for a novel phosphatase whose primary role is in cobalamin biosynthesis. A model for the sequence of biosynthetic steps that assemble the nucleotide loop of cobalamin in S. typhimurium is presented. ..
  31. Zayas C, Escalante Semerena J. Reassessment of the late steps of coenzyme B12 synthesis in Salmonella enterica: evidence that dephosphorylation of adenosylcobalamin-5'-phosphate by the CobC phosphatase is the last step of the pathway. J Bacteriol. 2007;189:2210-8 pubmed publisher
    ..Explanations for the correction of the Cby salvaging phenotype are discussed...
  32. Bortz D, Wu H, Schwarcz R, Bruno J. Oral administration of a specific kynurenic acid synthesis (KAT II) inhibitor attenuates evoked glutamate release in rat prefrontal cortex. Neuropharmacology. 2017;121:69-78 pubmed publisher
    ..The ability to prevent KYNA neosynthesis and to normalize evoked glutamate release in PFC justifies further development of KAT II inhibitors for the treatment of cognitive deficits in SZ. ..
  33. Basset G, Ravanel S, Quinlivan E, White R, Giovannoni J, R beill F, et al. Folate synthesis in plants: the last step of the p-aminobenzoate branch is catalyzed by a plastidial aminodeoxychorismate lyase. Plant J. 2004;40:453-61 pubmed publisher
    ..As shown previously for the ADC synthase transcript, the level of ADC lyase mRNA in the pericarp of tomato fruit falls sharply as ripening advances, suggesting that the expression of these two enzymes is coregulated...
  34. Brushaber K, O Toole G, Escalante Semerena J. CobD, a novel enzyme with L-threonine-O-3-phosphate decarboxylase activity, is responsible for the synthesis of (R)-1-amino-2-propanol O-2-phosphate, a proposed new intermediate in cobalamin biosynthesis in Salmonella typhimurium LT2. J Biol Chem. 1998;273:2684-91 pubmed
  35. Zhao G, Xia T, Song J, Jensen R. Pseudomonas aeruginosa possesses homologues of mammalian phenylalanine hydroxylase and 4 alpha-carbinolamine dehydratase/DCoH as part of a three-component gene cluster. Proc Natl Acad Sci U S A. 1994;91:1366-70 pubmed
    ..Expression of PhhA from its native promoter required phhB. This may suggest a positive regulatory role for phhB, consistent with the dual catalytic and regulatory roles of the corresponding mammalian homologue. ..
  36. Kim C, Yu T, Fryhle C, Handa S, Floss H. 3-Amino-5-hydroxybenzoic acid synthase, the terminal enzyme in the formation of the precursor of mC7N units in rifamycin and related antibiotics. J Biol Chem. 1998;273:6030-40 pubmed
    ..Inactivation of the gene encoding AHBA synthase in the A. mediterranei genome results in loss of rifamycin formation; production of the antibiotic is restored when the mutant is supplemented with AHBA. ..
  37. Monico C, Rossetti S, Olson J, Milliner D. Pyridoxine effect in type I primary hyperoxaluria is associated with the most common mutant allele. Kidney Int. 2005;67:1704-9 pubmed
    ..Mechanisms of VB6 action on hepatic alanine:glyoxylate aminotransferase (AGT), the deficient enzyme in PHI, and VB6 dose response have not been well-characterized...
  38. Zayas C, Woodson J, Escalante Semerena J. The cobZ gene of Methanosarcina mazei Go1 encodes the nonorthologous replacement of the alpha-ribazole-5'-phosphate phosphatase (CobC) enzyme of Salmonella enterica. J Bacteriol. 2006;188:2740-3 pubmed
    ..strain NRC-1. A strain of the latter carrying an in-frame deletion of ORF Vng1577 was not a cobalamin auxotroph, suggesting that either there is redundancy of this function in Halobacterium or the gene was misannotated...
  39. Maggio Hall L, Escalante Semerena J. In vitro synthesis of the nucleotide loop of cobalamin by Salmonella typhimurium enzymes. Proc Natl Acad Sci U S A. 1999;96:11798-803 pubmed
  40. Senger R, Papoutsakis E. Genome-scale model for Clostridium acetobutylicum: Part I. Metabolic network resolution and analysis. Biotechnol Bioeng. 2008;101:1036-52 pubmed publisher
    ..Systematic gene knock-out simulations were performed to identify a set of genes encoding clostridial enzymes essential for growth in silico...
  41. Mehendale H, Klingensmith J. In vivo metabolism of CCl4 by rats pretreated with chlordecone, mirex, or phenobarbital. Toxicol Appl Pharmacol. 1988;93:247-56 pubmed
  42. Hatch M, Gjymishka A, Salido E, Allison M, Freel R. Enteric oxalate elimination is induced and oxalate is normalized in a mouse model of primary hyperoxaluria following intestinal colonization with Oxalobacter. Am J Physiol Gastrointest Liver Physiol. 2011;300:G461-9 pubmed publisher
  43. Ruan X, Zhang C, Peters N. Bradyrhizobium japonicum rhizobitoxine genes and putative enzyme functions: expression requires a translational frameshift. Proc Natl Acad Sci U S A. 1993;90:2641-5 pubmed
    ..In Escherichia coli, this frameshift appears to be unusually efficient, occurring at a frequency of 80-90%...
  44. O Neill A, Ross P, Elliott G, Malley L, Kennedy G. Inhalation toxicity of dimethyl piperidinone. Toxicology. 2003;183:1-13 pubmed
  45. Ray K, Landmesser U, Leiter L, Kallend D, Dufour R, Karakas M, et al. Inclisiran in Patients at High Cardiovascular Risk with Elevated LDL Cholesterol. N Engl J Med. 2017;376:1430-1440 pubmed publisher
    ..Funded by the Medicines Company; ORION-1 ClinicalTrials.gov number, NCT02597127 .). ..
  46. Verslues P, Kim Y, Zhu J. Altered ABA, proline and hydrogen peroxide in an Arabidopsis glutamate:glyoxylate aminotransferase mutant. Plant Mol Biol. 2007;64:205-17 pubmed
    ..The results suggest that metabolic changes that alter H2O2 levels can affect both ABA accumulation and ABA sensitivity. ..
  47. Wang F, Metcalf T, van der Wel H, West C. Initiation of mucin-type O-glycosylation in dictyostelium is homologous to the corresponding step in animals and is important for spore coat function. J Biol Chem. 2003;278:51395-407 pubmed
  48. Gu W, Zhao G, Eddy C, Jensen R. Imidazole acetol phosphate aminotransferase in Zymomonas mobilis: molecular genetic, biochemical, and evolutionary analyses. J Bacteriol. 1995;177:1576-84 pubmed
    ..g., rat aspartate aminotransferase or E. coli AspC). Signature motifs which distinguish the IAP aminotransferase family were identified in the region of the active-site lysine and in the region of the interdomain interface...
  49. Lee W, McLeod L, Martin K, Emerson D, Galbraith R. Antibodies to polymerized human serum albumin in acute and chronic liver disease. Hepatology. 1987;7:906-12 pubmed
    ..Since they are evident early in acute hepatitis B when complexes of polyalbumin and virus are likely, these antibodies may play an adjunctive role to other hepatitis B-related antibodies in the clearance of hepatitis B virus infection. ..
  50. Dal Cin V, Tieman D, Tohge T, McQuinn R, De Vos R, Osorio S, et al. Identification of genes in the phenylalanine metabolic pathway by ectopic expression of a MYB transcription factor in tomato fruit. Plant Cell. 2011;23:2738-53 pubmed publisher
    ..However, while increased levels of these human nutrition-related phenylpropanoids may be desirable, there were no increases in levels of Phe-derived flavor volatiles...
  51. Bonner C, Fischer R, Ahmad S, Jensen R. Remnants of an ancient pathway to L-phenylalanine and L-tyrosine in enteric bacteria: evolutionary implications and biotechnological impact. Appl Environ Microbiol. 1990;56:3741-7 pubmed
    ..abstract truncated at 250 words) ..
  52. Lopes J, Soliman N, Smith P, Lawther R. Transcriptional polarity enhances the contribution of the internal promoter, ilvEp, in the expression of the ilvGMEDA operon in wild-type Escherichia coli K12. Mol Microbiol. 1989;3:1039-51 pubmed
    ..typhimurium. This analysis suggests that ilvEp contributes as much as 90% of ilvEDA expression in wild-type E. coli K12 and only 15% in wild-type S. typhimurium when grown under non-repressing conditions. ..
  53. Noble M, Kuhr C, Graves S, Loeb K, Sun S, KEILMAN G, et al. Ultrasound-targeted microbubble destruction-mediated gene delivery into canine livers. Mol Ther. 2013;21:1687-94 pubmed publisher
    ..7 MPa. Transaminase and histology analysis indicated minimal tissue damage. These experiments represent an important developmental step toward US-mediated gene delivery in large animals and clinics. ..
  54. Frey P. Radical mechanisms of enzymatic catalysis. Annu Rev Biochem. 2001;70:121-48 pubmed publisher
    ..Three examples are described of suicide inactivation through the formation of exceptionally stable free radicals at enzymatic active sites...
  55. Chistoserdova L, Lidstrom M. Genetics of the serine cycle in Methylobacterium extorquens AM1: identification of sgaA and mtdA and sequences of sgaA, hprA, and mtdA. J Bacteriol. 1994;176:1957-68 pubmed
    ..Our data suggest that this enzyme plays an integral role in methylotrophic metabolism in M. extorquens AM1, either in formaldehyde oxidation or as part of the serine cycle. ..
  56. Fetterly G, Owen J, Stuyckens K, Passarell J, Zannikos P, Soto Matos A, et al. Semimechanistic pharmacokinetic/pharmacodynamic model for hepatoprotective effect of dexamethasone on transient transaminitis after trabectedin (ET-743) treatment. Cancer Chemother Pharmacol. 2008;62:135-47 pubmed
    ..The model predicts that co-administration of dexamethasone and the suggested dose reduction strategy based on the serum concentration of liver enzymes will enhance the safe use of trabectedin in the clinic. ..
  57. Cook P, Holden H. GDP-perosamine synthase: structural analysis and production of a novel trideoxysugar. Biochemistry. 2008;47:2833-40 pubmed publisher
    ..Details describing the X-ray structural investigation of GDP-perosamine synthase and the enzymatic synthesis of GDP-4-amino-3,4,6-trideoxy- d-mannose are presented. ..
  58. Graham D, Huse H. Methanogens with pseudomurein use diaminopimelate aminotransferase in lysine biosynthesis. FEBS Lett. 2008;582:1369-74 pubmed publisher
    ..In contrast marine methanogens from the Methanococcales, which lack pseudomurein, appear to use a different diaminopimelate pathway for lysine biosynthesis. ..
  59. Smulski D, Huang L, McCluskey M, Reeve M, Vollmer A, Van Dyk T, et al. Combined, functional genomic-biochemical approach to intermediary metabolism: interaction of acivicin, a glutamine amidotransferase inhibitor, with Escherichia coli K-12. J Bacteriol. 2001;183:3353-64 pubmed
    ..The response to acivicin, however, was quite complex, suggesting that acivicin inhibition resonated through more than a single cellular process. ..