Experts and Doctors on trans activators in Japan


Locale: Japan
Topic: trans activators

Top Publications

  1. Takeda K, Kamanaka M, Tanaka T, Kishimoto T, Akira S. Impaired IL-13-mediated functions of macrophages in STAT6-deficient mice. J Immunol. 1996;157:3220-2 pubmed
    ..Taken together, these results suggest that the macrophage functions in response to IL-13 were impaired in STAT6-deficient mice, indicating that IL-13 and IL-4 share the signaling pathway via STAT6. ..
  2. Inoue K, Hoshijima K, Sakamoto H, Shimura Y. Binding of the Drosophila sex-lethal gene product to the alternative splice site of transformer primary transcript. Nature. 1990;344:461-3 pubmed
  3. Akira S, Nishio Y, Inoue M, Wang X, Wei S, Matsusaka T, et al. Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway. Cell. 1994;77:63-71 pubmed
  4. Miura N, Iida K, Kakinuma H, Yang X, Sugiyama T. Isolation of the mouse (MFH-1) and human (FKHL 14) mesenchyme fork head-1 genes reveals conservation of their gene and protein structures. Genomics. 1997;41:489-92 pubmed
    ..We also investigated the transcriptional activity of the mouse and human MFH-1 proteins and found that both proteins act as positive transactivators. ..
  5. Akiyama H, Shigeno C, Hiraki Y, Shukunami C, Kohno H, Akagi M, et al. Cloning of a mouse smoothened cDNA and expression patterns of hedgehog signalling molecules during chondrogenesis and cartilage differentiation in clonal mouse EC cells, ATDC5. Biochem Biophys Res Commun. 1997;235:142-7 pubmed
    ..Our data suggest that hh signalling molecules may be involved in chondrogenesis and cartilage differentiation in ATDC5 cells. ..
  6. Suda Y, Matsuo I, Aizawa S. Cooperation between Otx1 and Otx2 genes in developmental patterning of rostral brain. Mech Dev. 1997;69:125-41 pubmed
  7. Morita N, Uemura H, Tsumatani K, Cho M, Hirao Y, Okajima E, et al. E-cadherin and alpha-, beta- and gamma-catenin expression in prostate cancers: correlation with tumour invasion. Br J Cancer. 1999;79:1879-83 pubmed
    ..The data thus suggest that three types of catenin may be useful predictive markers for biological aggressiveness of prostate cancer. ..
  8. Yanagihara S, Iyoda S, Ohnishi K, Iino T, Kutsukake K. Structure and transcriptional control of the flagellar master operon of Salmonella typhimurium. Genes Genet Syst. 1999;74:105-11 pubmed
    ..The CRP-repressible transcription start site is located within this putative cAMP-CRP binding site. These two start sites were confirmed by in vitro transcription experiments using sigma 70-RNA polymerase with or without cAMP-CRP. ..
  9. Sei H, Oishi K, Morita Y, Ishida N. Mouse model for morningness/eveningness. Neuroreport. 2001;12:1461-4 pubmed

More Information

Publications169 found, 100 shown here

  1. Kimura M, Koseki Y, Yamashita M, Watanabe N, Shimizu C, Katsumoto T, et al. Regulation of Th2 cell differentiation by mel-18, a mammalian polycomb group gene. Immunity. 2001;15:275-87 pubmed
    ..Thus, the PcG gene products play a critical role in the control of Th2 cell differentiation and Th2-dependent immune responses. ..
  2. Yoshii T, Sakamoto M, Tomioka K. A temperature-dependent timing mechanism is involved in the circadian system that drives locomotor rhythms in the fruit fly Drosophila melanogaster. Zoolog Sci. 2002;19:841-50 pubmed
    ..It is thus suggested that dClk and cyc are also involved in determining the light-associated temperature preference in per(01) and tim(01) flies. ..
  3. Aono J, Yanagawa T, Itoh K, Li B, Yoshida H, Kumagai Y, et al. Activation of Nrf2 and accumulation of ubiquitinated A170 by arsenic in osteoblasts. Biochem Biophys Res Commun. 2003;305:271-7 pubmed
    ..These results provide the first direct evidence that toxic arsenics impair the normal function of A170. Our findings provide a potential diagnostic tool for monitoring biotoxicity in cells and tissues in response to arsenic compounds. ..
  4. Kasuga M, Miura S, Shinozaki K, Yamaguchi Shinozaki K. A combination of the Arabidopsis DREB1A gene and stress-inducible rd29A promoter improved drought- and low-temperature stress tolerance in tobacco by gene transfer. Plant Cell Physiol. 2004;45:346-50 pubmed
    ..These results indicate that a combination of the rd29A promoter and DREB1A is useful for improvement of various kinds of transgenic plants that are tolerant to environmental stress...
  5. Kobayashi H, Kawakami K, Asashima M, Nishinakamura R. Six1 and Six4 are essential for Gdnf expression in the metanephric mesenchyme and ureteric bud formation, while Six1 deficiency alone causes mesonephric-tubule defects. Mech Dev. 2007;124:290-303 pubmed
    ..These results highlight the fact that Six1 and Six4 have collaborative functions in the metanephros but not in the mesonephros. ..
  6. Yamamoto S, Morita M, Izumiya H, Watanabe H. Chitin disaccharide (GlcNAc)2 induces natural competence in Vibrio cholerae through transcriptional and translational activation of a positive regulatory gene tfoXVC. Gene. 2010;457:42-9 pubmed publisher
    ..These results suggested the dual activation of tfoX(VC) expression to be essential to induce competence. The highly transformable strain created here should aid the study of natural competence in V. cholerae. ..
  7. Sakurai H, Ohishi T, Fukasawa T. Promoter structure-dependent functioning of the general transcription factor IIE in Saccharomyces cerevisiae. J Biol Chem. 1997;272:15936-42 pubmed
    ..These results strongly suggest that requirement for TFIIE varies in each gene depending on the promoter structures in vivo. ..
  8. Fukasawa H, Yamaguchi M, Hashimoto Y, Endo Y, Shudo K. Enhancing effect of tumor promoters, phorbol esters and teleocidins on nuclear receptor-mediated transcription. Biol Pharm Bull. 2000;23:1414-7 pubmed
    ..These results suggest this reporter system is useful for the evaluation of effects on the gene expression of various tumor promoters, including non-TPA type. ..
  9. Torigoe T, Izumi H, Wakasugi T, Niina I, Igarashi T, Yoshida T, et al. DNA topoisomerase II poison TAS-103 transactivates GC-box-dependent transcription via acetylation of Sp1. J Biol Chem. 2005;280:1179-85 pubmed
    ..Taken together, these findings demonstrate novel genomic responses to anticancer agents that modulate Sp1 acetylation and Sp1-dependent transcription in an apoptotic pathway. ..
  10. Ohshima R, Ohta T, Wu W, Koike A, Iwatani T, Henderson M, et al. Putative tumor suppressor EDD interacts with and up-regulates APC. Genes Cells. 2007;12:1339-45 pubmed
    ..Thus, through protein-protein interaction, EDD stabilizes APC and up-regulates APC's function to inhibit beta-catenin, suggesting that EDD could act as a colorectal tumor suppressor. ..
  11. Ikawa Y. Pathogenesis of Friend leukemia virus. Leukemia. 1997;11 Suppl 3:152-4 pubmed
    ..JAK1 and STAT5 were constitutively tyrosine-phosphorylated but the DNA binding activity of STAT5 was not induced...
  12. Kikuchi A. Modulation of Wnt signaling by Axin and Axil. Cytokine Growth Factor Rev. 1999;10:255-65 pubmed
    ..Axil has similar functions to Axin. Thus, Axin and Axil act as scaffold proteins in the Wnt signaling pathway, thereby modulating the Wnt-dependent cellular functions. ..
  13. Nakajima H, Nakagawa E, Kobayashi K, Tagawa S, Aono S. Ligand-switching intermediates for the CO-sensing transcriptional activator CooA measured by pulse radiolysis. J Biol Chem. 2001;276:37895-9 pubmed
    ..9 ms (k = 3.5 x 10(2) x s(-1)) for wild-type CooA. The ligand exchange between Cys75 and His77 took place during the conversion of the second intermediate into the final reduced form. ..
  14. Tanimizu N, Saito H, Mostov K, Miyajima A. Long-term culture of hepatic progenitors derived from mouse Dlk+ hepatoblasts. J Cell Sci. 2004;117:6425-34 pubmed
  15. Iguchi H, Ikeda Y, Okamura M, Tanaka T, Urashima Y, Ohguchi H, et al. SOX6 attenuates glucose-stimulated insulin secretion by repressing PDX1 transcriptional activity and is down-regulated in hyperinsulinemic obese mice. J Biol Chem. 2005;280:37669-80 pubmed
    ..These results suggest that perturbations in transcriptional regulation that are coordinated through SOX6 and PDX1 in beta-cells may contribute to the beta-cell adaptation in obesity-related insulin resistance. ..
  16. Tamura T, Makino Y, Mikoshiba K, Muramatsu M. Demonstration of a testis-specific trans-acting factor Tet-1 in vitro that binds to the promoter of the mouse protamine 1 gene. J Biol Chem. 1992;267:4327-32 pubmed
    ..Although the first 8-mer in the Tet-1 11-mer shares homology with the cyclic AMP-responsive element, Tet-1 is demonstrated to be distinct from known cAMP-responsive element-binding factors. ..
  17. Tanaka T, Nagai R, Tomoike H, Takata S, Yano K, Yabuta K, et al. Four novel KVLQT1 and four novel HERG mutations in familial long-QT syndrome. Circulation. 1997;95:565-7 pubmed
    ..Such a variety of mutations makes it difficult to screen high-risk groups using simple methods such as endonuclease digestion or mutant allele-specific amplification. ..
  18. Nakada Y, Nishijyo T, Itoh Y. Divergent structure and regulatory mechanism of proline catabolic systems: characterization of the putAP proline catabolic operon of Pseudomonas aeruginosa PAO1 and its regulation by PruR, an AraC/XylS family protein. J Bacteriol. 2002;184:5633-40 pubmed
    ..Thus, the proline utilization system of P. aeruginosa differs from that of P. putida with respect to putA structure, the organization of the putAP genes, and the regulatory mechanism of putA expression. ..
  19. Tamai Y, Nakajima R, Ishikawa T, Takaku K, Seldin M, Taketo M. Colonic hamartoma development by anomalous duplication in Cdx2 knockout mice. Cancer Res. 1999;59:2965-70 pubmed
  20. Katoh M, Katoh M. Identification and characterization of TPARM gene in silico. Int J Oncol. 2003;23:1213-7 pubmed
    ..2. TPARM as well as NCAM1 and DRD2 were predicted to be candidate tumor suppressor genes within the commonly deleted region of malignant melanoma on 11q23.1-q23.2 (between microsatellite markers D11S1347 and D11S4122). ..
  21. Sano S, Chan K, Kira M, Kataoka K, Takagi S, Tarutani M, et al. Signal transducer and activator of transcription 3 is a key regulator of keratinocyte survival and proliferation following UV irradiation. Cancer Res. 2005;65:5720-9 pubmed
    ..These data suggest that Stat3 is required for survival and proliferation of keratinocytes following UVB exposure and that Stat3 is tightly regulated as part of a novel protective mechanism against UVB-induced skin cancer. ..
  22. Hiraga S, Sugiyama T, Itoh T. Comparative analysis of the replicon regions of eleven ColE2-related plasmids. J Bacteriol. 1994;176:7233-43 pubmed
    ..The mosaic structures of the replicon regions with homologous and nonhomologous segments suggest that some of them were generated by exchanging functional parts through homologous recombination...
  23. Takamatsu D, Osaki M, Sekizaki T. Sequence analysis of a small cryptic plasmid isolated from Streptococcus suis serotype 2. Curr Microbiol. 2000;40:61-6 pubmed
    ..Moreover, a 5-amino acid conserved sequence was found in C terminal of Rep and putative Rep proteins of several pMV158 family plasmids. These observations suggest that this plasmid replicates by use of the rolling circle mechanism...
  24. Takahashi M, Fujita M, Furukawa Y, Hamamoto R, Shimokawa T, Miwa N, et al. Isolation of a novel human gene, APCDD1, as a direct target of the beta-Catenin/T-cell factor 4 complex with probable involvement in colorectal carcinogenesis. Cancer Res. 2002;62:5651-6 pubmed
    ..These data suggest that APCDD1 is directly regulated by the beta-catenin/Tcf complex and that its elevated expression is likely to contribute to colorectal tumorigenesis. ..
  25. Komori H, Satomoto K, Ueda Y, Shibata N, Inagaki S, Yoshioka S, et al. Crystallization and preliminary X-ray analysis of CooA from Carboxydothermus hydrogenoformans. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006;62:471-3 pubmed
    ..7, c = 92.8 angstroms, beta = 104.8 degrees. The native and anomalous difference Patterson maps indicated that two CooA dimers are contained in the asymmetric unit and are related by a translational symmetry almost parallel to the c axis...
  26. Sakamoto K, Oishi K, Okada T, Onuma Y, Yokoyama K, Sugimoto K, et al. Molecular cloning of the cone-rod homeobox gene (Crx) from the rat and its temporal expression pattern in the retina under a daily light-dark cycle. Neurosci Lett. 1999;261:101-4 pubmed
    ..These findings suggest that the expression mechanism of rat Crx in the retina was different from that in the pineal, where Crx mRNA exhibits a daily expression rhythm. ..
  27. Hayashi R, Arauchi T, Tategu M, Goto Y, Yoshida K. A combined computational and experimental study on the structure-regulation relationships of putative mammalian DNA replication initiator GINS. Genomics Proteomics Bioinformatics. 2006;4:156-64 pubmed
    ..The goal of this study is to present the current data so as to encourage further work in the field of GINS gene regulation and functions in mammalian cells. ..
  28. Sugiura A, Nakashima K, Tanaka K, Mizuno T. Clarification of the structural and functional features of the osmoregulated kdp operon of Escherichia coli. Mol Microbiol. 1992;6:1769-76 pubmed
    ..e. in addition to them, a cis-acting sequence located upstream of the -35 region was essential for full activation of the promoter. This upstream sequence was demonstrated to be the target site for the trans-acting activator, KdpE. ..
  29. Tanaka S, Akiyoshi T, Mori M, Wands J, Sugimachi K. A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals. Proc Natl Acad Sci U S A. 1998;95:10164-9 pubmed
    ..These observations suggest that FzE3 gene expression may down-regulate APC function and enhance beta-catenin mediated signals in poorly differentiated human esophageal carcinomas. ..
  30. Taya S, Yamamoto T, Kanai Azuma M, Wood S, Kaibuchi K. The deubiquitinating enzyme Fam interacts with and stabilizes beta-catenin. Genes Cells. 1999;4:757-67 pubmed
    ..These results indicate that Fam interacts with and stabilizes beta-catenin in vivo, presumably through the deubiquitination of beta-catenin. ..
  31. Kawamori D, Kaneto H, Nakatani Y, Matsuoka T, Matsuhisa M, Hori M, et al. The forkhead transcription factor Foxo1 bridges the JNK pathway and the transcription factor PDX-1 through its intracellular translocation. J Biol Chem. 2006;281:1091-8 pubmed
    ..Taken together, Foxo1 is involved in the nucleocytoplasmic translocation of PDX-1 by oxidative stress and the JNK pathway. ..
  32. Ueda H, Hayashi S, Chen W, Sano M, Machida M, Shigeyoshi Y, et al. System-level identification of transcriptional circuits underlying mammalian circadian clocks. Nat Genet. 2005;37:187-92 pubmed
    ..Our analysis further suggests that regulation of E/E' boxes is a topological vulnerability in mammalian circadian clocks, a concept that has been functionally verified using in vitro phenotype assay systems. ..
  33. Akimaru H, Chen Y, Dai P, Hou D, Nonaka M, Smolik S, et al. Drosophila CBP is a co-activator of cubitus interruptus in hedgehog signalling. Nature. 1997;386:735-8 pubmed
    ..Here we show that Drosophila CBP (dCBP) functions as a coactivator of Ci, suggesting that the dCBP-Ci interaction may shed light on the contribution of CBP to pattern formation in mammals. ..
  34. Kumazaki S, Nakajima H, Sakaguchi T, Nakagawa E, Shinohara H, Yoshihara K, et al. Dissociation and recombination between ligands and heme in a CO-sensing transcriptional activator CooA. A flash photolysis study. J Biol Chem. 2000;275:38378-83 pubmed
    ..9 ns. The dynamics of rebinding of CO thus will help us to understand how the physiologically relevant diatomic molecule approaches the heme binding site in CooA with picosecond resolution. ..
  35. Hayashi A, Suzuki H, Itoh K, Yamamoto M, Sugiyama Y. Transcription factor Nrf2 is required for the constitutive and inducible expression of multidrug resistance-associated protein 1 in mouse embryo fibroblasts. Biochem Biophys Res Commun. 2003;310:824-9 pubmed
    ..This is the first demonstration that Nrf2 is required for the constitutive and inducible expression of Mrp family proteins. ..
  36. Tsunobuchi H, Ishisaki A, Imamura T. Expressions of inhibitory Smads, Smad6 and Smad7, are differentially regulated by TPA in human lung fibroblast cells. Biochem Biophys Res Commun. 2004;316:712-9 pubmed
    ..These findings indicate that TPA down-regulates Smad6 expression presumably via PKCmu-ERK-dependent pathway and up-regulates Smad7 expression via PKCmu-dependent mechanism(s) which need no MAPK and NF-kappaB activation. ..
  37. Nakano Y, Imagawa S, Matsumoto K, Stockmann C, Obara N, Suzuki N, et al. Oral administration of K-11706 inhibits GATA binding activity, enhances hypoxia-inducible factor 1 binding activity, and restores indicators in an in vivo mouse model of anemia of chronic disease. Blood. 2004;104:4300-7 pubmed
    ..These results raise the possibility of using orally administered K-11706 for treating patients with ACD. ..
  38. Nakayama S, Watanabe H. Mechanism of hilA repression by 1,2-propanediol consists of two distinct pathways, one dependent on and the other independent of catabolic production of propionate, in Salmonella enterica serovar Typhimurium. J Bacteriol. 2006;188:3121-5 pubmed
    ..A substrate of the enzyme, 1,2-propanediol, repressed hilA expression. The 1,2-propanediol-mediated repression at 150 mM, but not that at 300 mM, was abrogated by blocking the catabolism producing propionate from 1,2-propanediol. ..
  39. Iwasaki Y, Iwasaki H, Yatoh S, Ishikawa M, Kato T, Matsuzaka T, et al. Nuclear SREBP-1a causes loss of pancreatic beta-cells and impaired insulin secretion. Biochem Biophys Res Commun. 2009;378:545-50 pubmed publisher
    ..The transgenic mice on a high fat/high sucrose diet still exhibited impaired insulin secretion and continuous beta-cell growth defect. Therefore, nuclear SREBP-1a, even at a low level, strongly disrupts beta-cell mass and function. ..
  40. Ueguchi C, Ohta T, Seto C, Suzuki T, Mizuno T. The leuO gene product has a latent ability to relieve bgl silencing in Escherichia coli. J Bacteriol. 1998;180:190-3 pubmed
    ..A leuO deletion mutant was also characterized in terms of expression of bgl. From these results, the possible function of LeuO in bgl expression will be discussed from an evolutionary and/or ecological point of view. ..
  41. Inada M, Yasui T, Nomura S, Miyake S, Deguchi K, Himeno M, et al. Maturational disturbance of chondrocytes in Cbfa1-deficient mice. Dev Dyn. 1999;214:279-90 pubmed
    ..These findings demonstrate that Cbfa1 is an important factor for chondrocyte differentiation. ..
  42. Togashi H, Abe K, Mizoguchi A, Takaoka K, Chisaka O, Takeichi M. Cadherin regulates dendritic spine morphogenesis. Neuron. 2002;35:77-89 pubmed
    ..These findings suggest that cadherin regulates dendritic spine morphogenesis and related synaptic functions, presumably cooperating with cadherin-independent adhesive mechanisms to maintain spine-axon contacts. ..
  43. Naito Y, Tsujino T, Kawasaki D, Okumura T, Morimoto S, Masai M, et al. Circadian gene expression of clock genes and plasminogen activator inhibitor-1 in heart and aorta of spontaneously hypertensive and Wistar-Kyoto rats. J Hypertens. 2003;21:1107-15 pubmed
    ..Rather than clock genes, the renin-angiotensin system induces daily fluctuation and increased expression of aortic PAI-1 mRNA in SHR. ..
  44. Itoh K, Chiba T, Takahashi S, Ishii T, Igarashi K, Katoh Y, et al. An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. Biochem Biophys Res Commun. 1997;236:313-22 pubmed
    ..The nrf2-deficient mice may prove to be a very useful model for the in vivo analysis of chemical carcinogenesis and resistance to anti-cancer drugs. ..
  45. Tei H, Okamura H, Shigeyoshi Y, Fukuhara C, Ozawa R, Hirose M, et al. Circadian oscillation of a mammalian homologue of the Drosophila period gene. Nature. 1997;389:512-6 pubmed
    ..Clock, a mammalian clock gene encoding a PAS-containing polypeptide, has now been cloned: it is likely that the Per homologues dimerize with other molecule(s) such as Clock through PAS-PAS interaction in the circadian clock system. ..
  46. Shinmyo Y, Mito T, Uda T, Nakamura T, Miyawaki K, Ohuchi H, et al. brachyenteron is necessary for morphogenesis of the posterior gut but not for anteroposterior axial elongation from the posterior growth zone in the intermediate-germband cricket Gryllus bimaculatus. Development. 2006;133:4539-47 pubmed
  47. Nakashima N, Tanaka K, Sturm S, Okayama H. Fission yeast Rep2 is a putative transcriptional activator subunit for the cell cycle 'start' function of Res2-Cdc10. EMBO J. 1995;14:4794-802 pubmed
    ..Our data suggest that Rep2 is a transcriptional activator subunit which interacts with the MCB binding subunit complex formed by Res2 and Cdc10. ..
  48. Kawakami K, Ohto H, Takizawa T, Saito T. Identification and expression of six family genes in mouse retina. FEBS Lett. 1996;393:259-63 pubmed
    ..Six5 and Six2 bind to the same sequence as does AREC3/Six4, while Six3 does not. These observations suggest that some of the Six family genes can regulate the same target genes. ..
  49. Mizuno T, Nakazawa N, Remgsamrarn P, Kunoh T, Oshima Y, Harashima S. The Tup1-Ssn6 general repressor is involved in repression of IME1 encoding a transcriptional activator of meiosis in Saccharomyces cerevisiae. Curr Genet. 1998;33:239-47 pubmed
    ..These findings indicate that IME1 is negatively regulated by the Tup1-Ssn6 repressor complex through two distinct upstream regions in conjunction with unidentified DNA-binding proteins. ..
  50. Takatori N, Satou Y, Satoh N. Expression of hedgehog genes in Ciona intestinalis embryos. Mech Dev. 2002;116:235-8 pubmed
    ..Ci-hh2 was expressed zygotically in the tailbud embryo and its transcript was evident only in cells of the ventral nerve cord. The notochord cells did not express the hedgehog genes in Ciona embryos...
  51. Saika S, Muragaki Y, Okada Y, Miyamoto T, Ohnishi Y, Ooshima A, et al. Sonic hedgehog expression and role in healing corneal epithelium. Invest Ophthalmol Vis Sci. 2004;45:2577-85 pubmed
  52. Ozaki T, Nagase T, Ichimiya S, Seki N, Ohiri M, Nomura N, et al. NFBD1/KIAA0170 is a novel nuclear transcriptional transactivator with BRCT domain. DNA Cell Biol. 2000;19:475-85 pubmed
    ..These results suggest that NFBD1 is a nuclear transcriptional transactivator with possible BRCT domains and may contribute to cell growth control. ..
  53. Takahashi M, Tsunoda T, Seiki M, Nakamura Y, Furukawa Y. Identification of membrane-type matrix metalloproteinase-1 as a target of the beta-catenin/Tcf4 complex in human colorectal cancers. Oncogene. 2002;21:5861-7 pubmed
    ..Our results indicate that MT1-MMP is a direct down-stream target in the Wnt signaling pathway, and that one of the ways accumulated beta-catenin contributes to colorectal carcinogenesis is by transactivating this gene. ..
  54. Nishihara A, Watabe T, Imamura T, Miyazono K. Functional heterogeneity of bone morphogenetic protein receptor-II mutants found in patients with primary pulmonary hypertension. Mol Biol Cell. 2002;13:3055-63 pubmed
    ..The differences in biological activities among the BMPR-II mutants observed thus suggest that additional genetic and/or environmental factors may play critical roles in the pathogenesis of PPH. ..
  55. Watanabe N, Nishi M, Ikawa Y, Amanuma H. A deletion in the Friend spleen focus-forming virus env gene is necessary for its product (gp55) to be leukemogenic. J Virol. 1990;64:2678-86 pubmed
    ..These results indicate that for the pathogenic activity of gp55, a certain env deletion is necessary which causes production of a gp70-p15E fusion protein with an absence of at least the N-terminal one-third of the p15E-coding region...
  56. Naka T, Narazaki M, Hirata M, Matsumoto T, Minamoto S, Aono A, et al. Structure and function of a new STAT-induced STAT inhibitor. Nature. 1997;387:924-9 pubmed
    ..When SSI-1 is overexpressed in COS7 cells, it can associate with the kinases Jak2 and Tyk2. These findings indicate that SSI-1 is responsible for negative-feedback regulation of the JAK-STAT pathway induced by cytokine stimulation. ..
  57. Itoh T, Tanaka T, Nagai R, Kamiya T, Sawayama T, Nakayama T, et al. Genomic organization and mutational analysis of HERG, a gene responsible for familial long QT syndrome. Hum Genet. 1998;102:435-9 pubmed
    ..Each mutation was present in affected relatives of the respective proband. This work should increase the efficiency of screening mutations associated with HERG. ..
  58. Kusaba S, Fukumoto M, Honda C, Yamaguchi I, Sakamoto T, Kano Murakami Y. Decreased GA1 content caused by the overexpression of OSH1 is accompanied by suppression of GA 20-oxidase gene expression. Plant Physiol. 1998;117:1179-84 pubmed
    ..Based on these results, we conclude that overexpression of OSH1 causes a reduction of the level of GA1 by suppressing GA 20-oxidase expression...
  59. Moriya H, Isono K. Analysis of genetic interactions between DHH1, SSD1 and ELM1 indicates their involvement in cellular morphology determination in Saccharomyces cerevisiae. Yeast. 1999;15:481-96 pubmed
    ..A triple mutant, delta dhh1 ssd1-d delta elm1, apparently had very fragile cell walls and could grow only in a medium supplemented with 1 M sorbitol. ..
  60. Kurahashi T, Nomura T, Kanei Ishii C, Shinkai Y, Ishii S. The Wnt-NLK signaling pathway inhibits A-Myb activity by inhibiting the association with coactivator CBP and methylating histone H3. Mol Biol Cell. 2005;16:4705-13 pubmed
    ..Furthermore, NLK induced the methylation of histone H3 at lysine-9 at A-Myb-bound promoter regions. Thus, the Wnt-NLK pathway inhibits the activity of each Myb family member by different mechanisms. ..
  61. Suda S, Rai T, Sohara E, Sasaki S, Uchida S. Postnatal expression of KLF12 in the inner medullary collecting ducts of kidney and its trans-activation of UT-A1 urea transporter promoter. Biochem Biophys Res Commun. 2006;344:246-52 pubmed
    ..These results suggest that KLF12 is involved in the maturation processes of collecting ducts after birth, and that UT-A1 is a target gene of KLF12. ..
  62. Yamagata T, Nishida J, Sakai R, Tanaka T, Honda H, Hirano N, et al. Of the GATA-binding proteins, only GATA-4 selectively regulates the human interleukin-5 gene promoter in interleukin-5-producing cells which express multiple GATA-binding proteins. Mol Cell Biol. 1995;15:3830-9 pubmed
    ..These results demonstrate the selective role of GATA-4 in the transcriptional regulation of the IL-5 gene in a circumstance where multiple members of the GATA-binding proteins are expressed. ..
  63. Yasunami M, Suzuki K, Ohkubo H. A novel family of TEA domain-containing transcription factors with distinct spatiotemporal expression patterns. Biochem Biophys Res Commun. 1996;228:365-70 pubmed
  64. Hida A, Koike N, Hirose M, Hattori M, Sakaki Y, Tei H. The human and mouse Period1 genes: five well-conserved E-boxes additively contribute to the enhancement of mPer1 transcription. Genomics. 2000;65:224-33 pubmed
    ..Transient transfection assays using a mPer1-luciferase fusion gene revealed that each of the conserved E-boxes additively functions as an enhancer for the transactivation of mPer1 by mCLOCK and mBMAL1. ..
  65. Ishihara K, Satoh I, Mue S, Ohuchi K. Possible participation of a JAK2 signaling pathway in recombinant rat interleukin-5-induced prolongation of rat eosinophil survival. Biochim Biophys Acta. 2001;1536:73-84 pubmed
    ..STAT5 phosphorylation might also participate in the IL-5-induced survival of rat eosinophils. ..
  66. Hamada K, Shimizu T, Yonemura S, Tsukita S, Tsukita S, Hakoshima T. Structural basis of adhesion-molecule recognition by ERM proteins revealed by the crystal structure of the radixin-ICAM-2 complex. EMBO J. 2003;22:502-14 pubmed
    ..Mutation analyses based on the crystal structure reveal the determinant elements of recognition and provide the first insights into the physical link between adhesion molecules and ERM proteins. ..
  67. Uchikawa J, Shiozawa T, Shih H, Miyamoto T, Feng Y, Kashima H, et al. Expression of steroid receptor coactivators and corepressors in human endometrial hyperplasia and carcinoma with relevance to steroid receptors and Ki-67 expression. Cancer. 2003;98:2207-13 pubmed
    ..Accordingly, limited response to sex steroids in patients with endometrial carcinoma may be ascribed to the dissociation of cofactors and ER/PR. ..
  68. Iwakura H, Hosoda K, Son C, Fujikura J, Tomita T, Noguchi M, et al. Analysis of rat insulin II promoter-ghrelin transgenic mice and rat glucagon promoter-ghrelin transgenic mice. J Biol Chem. 2005;280:15247-56 pubmed
    ..The present study raises the possibility that desacyl ghrelin may have influence on glucose metabolism. ..
  69. Fujimoto E, Sato H, Shirai S, Nagashima Y, Fukumoto K, Hagiwara H, et al. Connexin32 as a tumor suppressor gene in a metastatic renal cell carcinoma cell line. Oncogene. 2005;24:3684-90 pubmed
    ..These data suggest that Cx32 acts as a tumor suppressor gene in Caki-1 cells and that the tumor-suppressive effect partly depends on the inhibition of Src-Stat3-VEGF signal pathway. ..
  70. Okanami M, Meshi T, Tamai H, Iwabuchi M. HALF-1, a bZIP-type protein, interacting with the wheat transcription factor HBP-1a contains a novel transcriptional activation domain. Genes Cells. 1996;1:87-99 pubmed
    ..We identified a novel trans-activation domain which contains the GCB motif conserved among plant bZIP-type factors. The trans-activation appears to be mediated by interaction between the GCB motif and a factor conserved in plants. ..
  71. Ohuchi H, Nakagawa T, Yamamoto A, Araga A, Ohata T, Ishimaru Y, et al. The mesenchymal factor, FGF10, initiates and maintains the outgrowth of the chick limb bud through interaction with FGF8, an apical ectodermal factor. Development. 1997;124:2235-44 pubmed
    ..These results suggest that FGF10 is a key mesenchymal factor involved in the initial budding as well as the continuous outgrowth of vertebrate limbs. ..
  72. Tanikawa J, Ichikawa Iwata E, Kanei Ishii C, Nakai A, Matsuzawa S, Reed J, et al. p53 suppresses the c-Myb-induced activation of heat shock transcription factor 3. J Biol Chem. 2000;275:15578-85 pubmed
    ..The regulation of HSF3 activity by c-Myb and p53 sheds light on the molecular events that govern HSP expression during cellular proliferation and apoptosis. ..
  73. Aono S, Honma Y, Ohkubo K, Tawara T, Kamiya T, Nakajima H. CO sensing and regulation of gene expression by the transcriptional activator CooA. J Inorg Biochem. 2000;82:51-6 pubmed
  74. Xiangming C, Natsugoe S, Takao S, Hokita S, Ishigami S, Tanabe G, et al. Preserved Smad4 expression in the transforming growth factor beta signaling pathway is a favorable prognostic factor in patients with advanced gastric cancer. Clin Cancer Res. 2001;7:277-82 pubmed
    ..05). According to multivariate analysis, Smad4 expression acted as an independent prognostic factor. Smad4 expression, particularly in the TGF-beta pathway, is an effective predictor of outcome for patients with advanced gastric cancer. ..
  75. Jin C, Li H, Murata T, Sun K, Horikoshi M, Chiu R, et al. JDP2, a repressor of AP-1, recruits a histone deacetylase 3 complex to inhibit the retinoic acid-induced differentiation of F9 cells. Mol Cell Biol. 2002;22:4815-26 pubmed
    ..These results suggest that JDP2 may be a key factor that controls the commitment of F9 cells to differentiation and shed new light on the mechanism by which an AP-1 repressor functions. ..
  76. Muroya S, Nakajima I, Chikuni K. Related expression of MyoD and Myf5 with myosin heavy chain isoform types in bovine adult skeletal muscles. Zoolog Sci. 2002;19:755-61 pubmed
    ..The results suggest that MyoD and Myf5 influence the MyHC isoform expression, although the effects are not decisive in specifying the phenotypes of adult muscles. ..
  77. Uemura H, Jigami Y. Role of GCR2 in transcriptional activation of yeast glycolytic genes. Mol Cell Biol. 1992;12:3834-42 pubmed
    ..Furthermore, a Rap1/Gcr2 fusion protein partially complemented the defects of gcr1 strains. These results suggest that Gcr2 has transcriptional activation activity and that the GCR1 and GCR2 gene products function together. ..
  78. Urao T, Noji M, Yamaguchi Shinozaki K, Shinozaki K. A transcriptional activation domain of ATMYB2, a drought-inducible Arabidopsis Myb-related protein. Plant J. 1996;10:1145-8 pubmed
    ..These results indicate that ATMYB2 acts as a transcriptional activator and that the C-terminal acidic region of ATMYB2 can function as a transcriptional activation domain. ..
  79. Sawado T, Yamaguchi M, Nishimoto Y, Ohno K, Sakaguchi K, Matsukage A. dE2F2, a novel E2F-family transcription factor in Drosophila melanogaster. Biochem Biophys Res Commun. 1998;251:409-15 pubmed
    ..Furthermore, cotransfection experiments in Kc cells demonstrated dE2F2 repression of the PCNA gene promoter activity, while dE2F caused activation, the target site for the repression being identical to the dE2F-recognition site. ..
  80. Sakurai H, Fukasawa T. Functional connections between mediator components and general transcription factors of Saccharomyces cerevisiae. J Biol Chem. 2000;275:37251-6 pubmed
    ..We illustrate genetic interactions between Gal11 and other Mediator components such as Med2 and Pgd1/Hrs1/Med3. ..
  81. Kamiya A, Kinoshita T, Miyajima A. Oncostatin M and hepatocyte growth factor induce hepatic maturation via distinct signaling pathways. FEBS Lett. 2001;492:90-4 pubmed
    ..These results indicate that OSM and HGF induce hepatic maturation through different signaling pathways. ..
  82. Gunduz M, Ouchida M, Fukushima K, Ito S, Jitsumori Y, Nakashima T, et al. Allelic loss and reduced expression of the ING3, a candidate tumor suppressor gene at 7q31, in human head and neck cancers. Oncogene. 2002;21:4462-70 pubmed
    ..All these findings suggest a possibility that the ING3 gene functions as a TSG in a subset of HNSCC. ..
  83. Kume S, Kobayashi F, Ishibashi M, Ohno R, Nakamura C, Takumi S. Differential and coordinated expression of Cbf and Cor/Lea genes during long-term cold acclimation in two wheat cultivars showing distinct levels of freezing tolerance. Genes Genet Syst. 2005;80:185-97 pubmed
  84. Shinohara M, Itoh T. Specificity determinants in interaction of the initiator (Rep) proteins with the origins in the plasmids ColE2-P9 and ColE3-CA38 identified by chimera analysis. J Mol Biol. 1996;257:290-300 pubmed
    ..Among other possibilities we propose that the region A is a linker connecting the two domains in the Rep protein involved in DNA-binding and that the region B is a part of the sequence-specific DNA-binding domain. ..
  85. Koyama H, Kurokawa T, Nonami T, Nakao A, Sugiyama S, Murakami T, et al. Increases in the mitochondrial DNA replication and transcription in the remnant liver of rats. Biochem Biophys Res Commun. 1998;243:858-61 pubmed
  86. Yamamoto H, Kishida S, Uochi T, Ikeda S, Koyama S, Asashima M, et al. Axil, a member of the Axin family, interacts with both glycogen synthase kinase 3beta and beta-catenin and inhibits axis formation of Xenopus embryos. Mol Cell Biol. 1998;18:2867-75 pubmed
    ..These results indicate that Axil negatively regulates the Wnt signaling pathway by mediating GSK-3beta-dependent phosphorylation of beta-catenin, thereby inhibiting axis formation. ..
  87. Ishitani T, Kishida S, Hyodo Miura J, Ueno N, Yasuda J, Waterman M, et al. The TAK1-NLK mitogen-activated protein kinase cascade functions in the Wnt-5a/Ca(2+) pathway to antagonize Wnt/beta-catenin signaling. Mol Cell Biol. 2003;23:131-9 pubmed
    ..These results suggest that the TAK1-NLK MAPK cascade is activated by the noncanonical Wnt-5a/Ca(2+) pathway and antagonizes canonical Wnt/beta-catenin signaling. ..
  88. Katoh M, Katoh M. Human FOX gene family (Review). Int J Oncol. 2004;25:1495-500 pubmed
  89. Nakano H, Shimada A, Imai K, Takahashi T, Hashizume K. The cytoplasmic expression of E-cadherin and beta-catenin in bovine trophoblasts during binucleate cell differentiation. Placenta. 2005;26:393-401 pubmed
  90. Katoh Y, Katoh M. Hedgehog signaling pathway and gastric cancer. Cancer Biol Ther. 2005;4:1050-4 pubmed
    ..Genetic screening and precise selection of therapeutic options would contribute to the realization of personalized medicine. ..
  91. Sugiyama T, Nishio Y, Kishimoto T, Akira S. Identification of alternative splicing form of Stat2. FEBS Lett. 1996;381:191-4 pubmed
    ..The significance of these spliced forms is discussed. ..
  92. Aono S, Nakajima H, Saito K, Okada M. A novel heme protein that acts as a carbon monoxide-dependent transcriptional activator in Rhodospirillum rubrum. Biochem Biophys Res Commun. 1996;228:752-6 pubmed
    ..CO-bound CooA was formed when reduced CooA was reacted with CO, but not in the case of oxidized CooA. CooA is the first example of the heme protein acting as a DNA-binding transcriptional activator. ..