Experts and Doctors on tissue distribution in United States

Summary

Locale: United States
Topic: tissue distribution

Top Publications

  1. Reiter J, Threadgill D, Eley G, Strunk K, Danielsen A, Sinclair C, et al. Comparative genomic sequence analysis and isolation of human and mouse alternative EGFR transcripts encoding truncated receptor isoforms. Genomics. 2001;71:1-20 pubmed
    ..The presence of truncated receptor isoforms in diverse species suggests that these proteins may have important functional roles in regulating EGFR activity. ..
  2. Nyako M, Marks C, Sherma J, Reynolds E. Tissue-specific and developmental effects of the easily shocked mutation on ethanolamine kinase activity and phospholipid composition in Drosophila melanogaster. Biochem Genet. 2001;39:339-49 pubmed
    ..While PE levels were decreased significantly in both tissues, heads also had significantly less phosphatidylserine (PS). Therefore, decreases in both phospholipids may play a role in producing the aberrant phenotype in eas flies. ..
  3. Widmer C, Morris Wiman J, Nekula C. Spatial distribution of myosin heavy-chain isoforms in mouse masseter. J Dent Res. 2002;81:33-8 pubmed
    ..The regionalization of muscle fiber types in the mouse masseter is consistent with the functional compartmentalization of the masseter observed in other species. ..
  4. Lerant A, Demaria J, Freeman M. Decreased expression of fos-related antigens (FRAs) in the hypothalamic dopaminergic neurons after immunoneutralization of endogenous prolactin. Endocrine. 2001;16:181-7 pubmed
    ..These results indicate that elimination of endogenous prolactin from the circulation lowers the activity and/or prevents the reactivation of neuroendocrine dopaminergic neurons at the beginning of the dark phase. ..
  5. Inoue K, Zhuang L, Maddox D, Smith S, Ganapathy V. Structure, function, and expression pattern of a novel sodium-coupled citrate transporter (NaCT) cloned from mammalian brain. J Biol Chem. 2002;277:39469-76 pubmed
    ..NaCT thus constitutes a potential therapeutic target for the control of body weight, cholesterol levels, and energy homeostasis. ..
  6. Rogers B, Bigott H, McCarthy D, Della Manna D, Kim J, Sharp T, et al. MicroPET imaging of a gastrin-releasing peptide receptor-positive tumor in a mouse model of human prostate cancer using a 64Cu-labeled bombesin analogue. Bioconjug Chem. 2003;14:756-63 pubmed
    ..This study demonstrates that (64)Cu-DOTA-Aoc-BN(7-14) can be used to detect GRPR-positive tumors by PET imaging. ..
  7. Nottingham S, Springer J. Temporal and spatial distribution of activated caspase-3 after subdural kainic acid infusions in rat spinal cord. J Comp Neurol. 2003;464:463-71 pubmed
    ..In addition, understanding the apoptotic signaling events activated by glutamate will be important for developing therapies targeting this cell death process. ..
  8. Xu L, Eiseman J, Egorin M, D Argenio D. Physiologically-based pharmacokinetics and molecular pharmacodynamics of 17-(allylamino)-17-demethoxygeldanamycin and its active metabolite in tumor-bearing mice. J Pharmacokinet Pharmacodyn. 2003;30:185-219 pubmed
    ..In modeling pharmacokmetics and pharmacodynamics, Bayesian inference was employed to estimate the kinetic, physiological and molecular parameters when prior information was available. ..
  9. Shimizu M, Dickey J, Fukada H, Dickhoff W. Salmon serum 22 kDa insulin-like growth factor-binding protein (IGFBP) is IGFBP-1. J Endocrinol. 2005;184:267-76 pubmed
    ..These findings suggest that association with the cell surface and turnover rate may differ between salmon and mammalian IGFBP-1. ..

More Information

Publications311 found, 100 shown here

  1. Bergrin M, Bicer S, Lucas C, Reiser P. Three-dimensional compartmentalization of myosin heavy chain and myosin light chain isoforms in dog thyroarytenoid muscle. Am J Physiol Cell Physiol. 2006;290:C1446-58 pubmed
    ..Variations of MHC and MLC isoform expression in the dog thyroarytenoid muscle are greater than previously recognized and suggest an even broader range of contractile properties within this multifunctional muscle. ..
  2. Vanden Heuvel G, Payne J, Igarashi P, Forbush B. Expression of the basolateral Na-K-Cl cotransporter during mouse nephrogenesis and embryonic development. Gene Expr Patterns. 2006;6:1000-6 pubmed
    ..Slc12a2 expression was also observed in the developing central and peripheral nervous systems, including choroid plexus and trigeminal and dorsal root ganglia...
  3. Hernandez P, Schiltz C, Kelley A. Dynamic shifts in corticostriatal expression patterns of the immediate early genes Homer 1a and Zif268 during early and late phases of instrumental training. Learn Mem. 2006;13:599-608 pubmed
  4. Shin S, Bian G, Raikhel A. A toll receptor and a cytokine, Toll5A and Spz1C, are involved in toll antifungal immune signaling in the mosquito Aedes aegypti. J Biol Chem. 2006;281:39388-95 pubmed publisher
    ..These data suggest that Toll5A and Spz1C function as cytokine receptor systems specific to the Toll receptor-mediated immune response following fungal challenge in the mosquito fat body...
  5. Lan Z, Xu X, Chung A, Cooney A. Extra-germ cell expression of mouse nuclear receptor subfamily 6, group A, member 1 (NR6A1). Biol Reprod. 2009;80:905-12 pubmed publisher
    ..The extra-germ cell expression of NR6A1 makes it a less attractive contraceptive. ..
  6. Simo L, Zitnan D, Park Y. Two novel neuropeptides in innervation of the salivary glands of the black-legged tick, Ixodes scapularis: myoinhibitory peptide and SIFamide. J Comp Neurol. 2009;517:551-63 pubmed publisher
    ..Our data provide evidence for neural control of salivary gland by MIP and SIFamide from the synganglion, thus leading a basis for functional studies of these two distinct classes of neuropeptides. ..
  7. Day R, Keller J, Harms C, Segars A, Cluse W, Godfrey M, et al. Comparison of mercury burdens in chronically debilitated and healthy loggerhead sea turtles (Caretta caretta). J Wildl Dis. 2010;46:111-7 pubmed
    ..These findings suggest that Hg toxicity does not play a role in the debilitated loggerhead condition observed in the southeastern United States. ..
  8. Opitz A, Wickstrom E, Thakur M, Wagner N. Physiologically based pharmacokinetics of molecular imaging nanoparticles for mRNA detection determined in tumor-bearing mice. Oligonucleotides. 2010;20:117-25 pubmed publisher
    ..This result suggests that previous mouse imaging trials used more MINs than necessary. This prediction can be tested by a ramp of decreasing doses...
  9. Ni W, Ji J, Dai Z, Papp A, Johnson A, Ahn S, et al. Flavopiridol pharmacogenetics: clinical and functional evidence for the role of SLCO1B1/OATP1B1 in flavopiridol disposition. PLoS ONE. 2010;5:e13792 pubmed publisher
    ..This study aimed to evaluate pharmacogenetic factors associated with inter-individual variability in pharmacokinetics and outcomes associated with flavopiridol therapy...
  10. Blum K, Ruppert A, Woyach J, Jones J, Andritsos L, Flynn J, et al. Risk factors for tumor lysis syndrome in patients with chronic lymphocytic leukemia treated with the cyclin-dependent kinase inhibitor, flavopiridol. Leukemia. 2011;25:1444-51 pubmed publisher
    ..TLS does not appear to be predictive of response or improved PFS in patients receiving flavopiridol. ..
  11. Zhou X, Smith A, Failla M, Hill K, Yu Z. Estrogen status alters tissue distribution and metabolism of selenium in female rats. J Nutr Biochem. 2012;23:532-8 pubmed publisher
    ..These results suggest that estrogen status affects tissue distribution of selenium by modulating Sepp1, as this protein plays a central role in selenium transport...
  12. Weekes C, Von Hoff D, Adjei A, Leffingwell D, Eckhardt S, Gore L, et al. Multicenter phase I trial of the mitogen-activated protein kinase 1/2 inhibitor BAY 86-9766 in patients with advanced cancer. Clin Cancer Res. 2013;19:1232-43 pubmed publisher
    ..This phase I study showed that BAY 86-9766 was well-tolerated, with good oral absorption, dose proportional pharmacokinetics, target inhibition at the MTD, and some evidence of clinical benefit across a range of tumor types. ..
  13. Naray Fejes Toth A, Fejes Toth G. Expression cloning of the aldosterone target cell-specific 11 beta-hydroxysteroid dehydrogenase from rabbit collecting duct cells. Endocrinology. 1995;136:2579-86 pubmed
    ..These data suggest that the 11 beta-OHSD cDNA from rabbit collecting duct cells encodes the enzyme that confers aldosterone selectivity to mineralocorticoid target cells. ..
  14. Takahashi K, Donovan M, Rogers R, Ezekowitz R. Distribution of murine mannose receptor expression from early embryogenesis through to adulthood. Cell Tissue Res. 1998;292:311-23 pubmed
    ..This study demonstrates that the mannose receptor is expressed on tissue macrophages and on subsets of vascular and lymphatic endothelial cells. Thus, the mannose receptor maybe a marker of the so-called reticuloendothelial system. ..
  15. Huang H, Reed C, Zhang J, Shridhar V, Wang L, Smith D. Carboxypeptidase A3 (CPA3): a novel gene highly induced by histone deacetylase inhibitors during differentiation of prostate epithelial cancer cells. Cancer Res. 1999;59:2981-8 pubmed
    ..Our data demonstrate that the histone hyperacetylation signaling pathway is activated during NaBu-mediated differentiation of PC-3 cells, and the new gene, CPA3, is involved in this pathway. ..
  16. Manley K, Shirley T, Flaherty L, Messer A. Msh2 deficiency prevents in vivo somatic instability of the CAG repeat in Huntington disease transgenic mice. Nat Genet. 1999;23:471-3 pubmed
    ..16) with Msh2-/- mice. Our results show that Msh2 is required for somatic instability of the CAG repeat. ..
  17. Dinchuk J, Henderson N, Burn T, Huber R, Ho S, Link J, et al. Aspartyl beta -hydroxylase (Asph) and an evolutionarily conserved isoform of Asph missing the catalytic domain share exons with junctin. J Biol Chem. 2000;275:39543-54 pubmed
    ..This unusual form of exon sharing suggests that the functions of junctin, BAH, and humbug may be linked. ..
  18. Pingree S, Simmonds P, Rummel K, Woods J. Quantitative evaluation of urinary porphyrins as a measure of kidney mercury content and mercury body burden during prolonged methylmercury exposure in rats. Toxicol Sci. 2001;61:234-40 pubmed
    ..These findings demonstrate that urinary porphyrin concentrations relate quantitatively to DMPS-mobilizable mercury in the kidney and, therefore, serve as a biochemical measure of renal mercury content. ..
  19. Cherrington N, Hartley D, Li N, Johnson D, Klaassen C. Organ distribution of multidrug resistance proteins 1, 2, and 3 (Mrp1, 2, and 3) mRNA and hepatic induction of Mrp3 by constitutive androstane receptor activators in rats. J Pharmacol Exp Ther. 2002;300:97-104 pubmed
    ..We conclude that rat hepatic Mrp3 is induced by CAR activators, thus enhancing the vectoral excretion of some phase II metabolites from the liver to the blood. ..
  20. Liu Y, Hair G, Boden S, Viggeswarapu M, Titus L. Overexpressed LIM mineralization proteins do not require LIM domains to induce bone. J Bone Miner Res. 2002;17:406-14 pubmed
    ..These findings suggest that the LIM domains are not required for LMPs to induce bone formation. In addition, a small region (36 AA) of the LMP-1 protein may be required for bone formation. ..
  21. Whanger P. Selenoprotein W. Methods Enzymol. 2002;347:179-87 pubmed
  22. Chen D, Hackbarth C, Ni Z, Wu C, Wang W, Jain R, et al. Peptide deformylase inhibitors as antibacterial agents: identification of VRC3375, a proline-3-alkylsuccinyl hydroxamate derivative, by using an integrated combinatorial and medicinal chemistry approach. Antimicrob Agents Chemother. 2004;48:250-61 pubmed
    ..v., p.o., or s.c. administration. The in vivo efficacy and low toxicity of VRC3375 suggest the potential for developing this class of compounds to be used in future antibacterial drugs. ..
  23. Dai L, Dewey E, Zitnan D, Luo C, Honegger H, Adams M. Identification, developmental expression, and functions of bursicon in the tobacco hawkmoth, Manduca sexta. J Comp Neurol. 2008;506:759-74 pubmed
    ..Recombinant bursicon induces both wing expansion and tanning, whereas synthetic eclosion hormone induces only wing expansion...
  24. Roselli C, Bocklandt S, Stadelman H, Wadsworth T, Vilain E, Stormshak F. Prolactin expression in the sheep brain. Neuroendocrinology. 2008;87:206-15 pubmed publisher
  25. Xiong M, Yáñez J, Remsberg C, Ohgami Y, Kwon G, Davies N, et al. Formulation of a geldanamycin prodrug in mPEG-b-PCL micelles greatly enhances tolerability and pharmacokinetics in rats. J Control Release. 2008;129:33-40 pubmed publisher
    ..Overall, the data indicate that this nanocarrier system is a promising alternative to the current 17-DMAG formulation and offers excellent potential for further pre-clinical and clinical cancer studies. ..
  26. Yang T, Chaudhuri S, Yang L, Du L, Poovaiah B. A calcium/calmodulin-regulated member of the receptor-like kinase family confers cold tolerance in plants. J Biol Chem. 2010;285:7119-26 pubmed publisher
    ..These results indicate that CRLK1 is a positive regulator of cold tolerance in plants. Furthermore, our results suggest that CRLK1 plays a role in bridging calcium/calmodulin signaling and cold signaling. ..
  27. Karacay H, Sharkey R, McBride W, Rossi E, Chang C, Goldenberg D. Optimization of hapten-peptide labeling for pretargeted immunoPET of bispecific antibody using generator-produced 68Ga. J Nucl Med. 2011;52:555-9 pubmed publisher
    ..5 h after peptide injection. High-specific-activity labeling of DOTA-hapten-peptide was obtained from the (68)Ga/(68)Ge generator for approximately 1 y, yielding products suitable for immunoPET. ..
  28. Molina M, Qu H, Rentfro A, Nair S, Lu Y, Hanis C, et al. Decreased expression of ATP6V1H in type 2 diabetes: a pilot report on the diabetes risk study in Mexican Americans. Biochem Biophys Res Commun. 2011;412:728-31 pubmed publisher
    ..ATP6V1H may represent a critical molecular mechanism involved in the development of type 2 diabetes and its compilations through its important regulatory effect on vacuolar-ATPase activity. ..
  29. Mehta V, Abler L, Keil K, Schmitz C, Joshi P, Vezina C. Atlas of Wnt and R-spondin gene expression in the developing male mouse lower urogenital tract. Dev Dyn. 2011;240:2548-60 pubmed publisher
    ..These results reveal sexual differences in WNT/?-catenin signaling in fetal LUT, supporting the idea that this pathway may be directly or indirectly responsive to androgens during prostate ductal development. ..
  30. Wiersma P, Nowak B, Williams J. Small organ size contributes to the slow pace of life in tropical birds. J Exp Biol. 2012;215:1662-9 pubmed publisher
    ..Feather mass was 37% lower in tropical species compared with similar-sized temperate birds, supporting the idea that temperate birds require more insulation for thermoregulation. ..
  31. Domoradzki J, Sushynski C, Sushynski J, McNett D, Van Landingham C, Plotzke K. Metabolism and disposition of [14C]-methylcyclosiloxanes in rats. Toxicol Lett. 2017;279 Suppl 1:98-114 pubmed publisher
    ..With a refined oral uptake description, the model could be used in risk assessment to better define the internal dose of D4 and D5 following exposure to D4 and D5 via multiple routes. ..
  32. Grandy D, Hanneman E, Bunzow J, Shih M, Machida C, Bidlack J, et al. Purification, cloning, and tissue distribution of a 23-kDa rat protein isolated by morphine affinity chromatography. Mol Endocrinol. 1990;4:1370-6 pubmed
    ..Although not an opioid receptor itself, this protein may be associated with such a receptor or be related to a protein that has been shown to be cross-linked to the opioid peptide beta-endorphin. ..
  33. Patel S, Aebersold R, Attardi G. cDNA-derived amino acid sequence of the NADH-binding 51-kDa subunit of the bovine respiratory NADH dehydrogenase reveals striking similarities to a bacterial NAD(+)-reducing hydrogenase. Proc Natl Acad Sci U S A. 1991;88:4225-9 pubmed
    ..In particular, there are three segments of high sequence similarity (70-88%) between the two proteins which correspond to the three ligand-binding sites. ..
  34. Chao S, Chai K, Chao L, Chao J. Molecular cloning and primary structure of rat alpha 1-antitrypsin. Biochemistry. 1990;29:323-9 pubmed
    ..Northern blot analysis using the cDNA probe showed that rat alpha 1-antitrypsin is expressed at high levels in the liver and at low levels in the submandibular gland and the lung.(ABSTRACT TRUNCATED AT 250 WORDS) ..
  35. Johnson J, Grande J, Roche P, Kumar R. Immunohistochemical localization of the 1,25(OH)2D3 receptor and calbindin D28k in human and rat pancreas. Am J Physiol. 1994;267:E356-60 pubmed
    ..These findings suggest that 1,25(OH)2D3 may influence both endocrine and exocrine pancreatic function...
  36. Choudhuri S, Liu W, Berman N, Klaassen C. Cadmium accumulation and metallothionein expression in brain of mice at different stages of development. Toxicol Lett. 1996;84:127-33 pubmed
    ..Cd distribution to brain was found to decrease with age; the brains of 7-day-old mice contained about 4-times more Cd than that of adult mice. Thus, an inverse correlation was observed between MT expression and Cd accumulation in brain. ..
  37. Chai X, Zhai Y, Napoli J. Cloning of a rat cDNA encoding retinol dehydrogenase isozyme type III. Gene. 1996;169:219-22 pubmed
    ..These data extend the insight that a subfamily of SDR isozymes, tissue-distinctively expressed, catalyzes the first step in RA biogenesis. ..
  38. Panus P, Tober Meyer B, Ferslew K. Tissue extraction and high-performance liquid chromatographic determination of ketoprofen entantiomers. J Chromatogr B Biomed Sci Appl. 1998;705:295-302 pubmed
    ..This represents the first non-radioactive method for determination of ketoprofen in tissues following transcutaneous iontophoresis. ..
  39. Berwin B, Floor E, Martin T. CAPS (mammalian UNC-31) protein localizes to membranes involved in dense-core vesicle exocytosis. Neuron. 1998;21:137-45 pubmed
    ..CAPS is a functional component of the exocytotic machinery that localizes selectively to DCVs, and it may confer distinct regulatory features on neuropeptide and biogenic amine transmitter secretion. ..
  40. Conroy C, Maren T. The ocular distribution of methazolamide after corneal and scleral administration: the effect of ionization state. J Ocul Pharmacol Ther. 1998;14:565-73 pubmed
  41. Fallavollita J, Jacob S, Young R, Canty J. Regional alterations in SR Ca(2+)-ATPase, phospholamban, and HSP-70 expression in chronic hibernating myocardium. Am J Physiol. 1999;277:H1418-28 pubmed publisher
    ..This supports the hypothesis that SR dysfunction from reversible ischemia may be an early defect in the progression of left ventricular dysfunction. ..
  42. Hicar M, Liu Y, Allen C, Wu L. Structure of the human zinc finger protein HIVEP3: molecular cloning, expression, exon-intron structure, and comparison with paralogous genes HIVEP1 and HIVEP2. Genomics. 2001;71:89-100 pubmed
  43. Moritz O, Tam B, Papermaster D, Nakayama T. A functional rhodopsin-green fluorescent protein fusion protein localizes correctly in transgenic Xenopus laevis retinal rods and is expressed in a time-dependent pattern. J Biol Chem. 2001;276:28242-51 pubmed
  44. Gerencser G, Zhang J. Chloride ATPase pumps in nature: do they exist?. Biol Rev Camb Philos Soc. 2003;78:197-218 pubmed
    ..Contemporary evidence points to the existence of Cl(-)-ATPase pumps; however, these primary active transporters exist as either P-, F- or V-type ATPase pumps depending upon the tissue under study. ..
  45. Miyazaki M, Jacobson M, Man W, Cohen P, Asilmaz E, Friedman J, et al. Identification and characterization of murine SCD4, a novel heart-specific stearoyl-CoA desaturase isoform regulated by leptin and dietary factors. J Biol Chem. 2003;278:33904-11 pubmed
    ..The current studies identify a novel heart-specific SCD isoform that demonstrates tissue-specific regulation by leptin and dietary factors. ..
  46. Steenhard B, Freeburg P, Isom K, Stroganova L, Borza D, Hudson B, et al. Kidney development and gene expression in the HIF2alpha knockout mouse. Dev Dyn. 2007;236:1115-25 pubmed
    ..Our results show that, although HIF2alpha was widely transcribed by kidney endothelium and vascular smooth muscle, knockouts displayed no detectable deficits in vessel development or VEGF or Flk-1 expression. ..
  47. Yeh H, Klesius P. Channel catfish (Ictalurus punctatus Rafinesque, 1818) CD156a (ADAM metallopeptidase domain 8): cDNA clone, characterization and expression in tissues. Vet Immunol Immunopathol. 2009;132:307-13 pubmed publisher
    ..Reagents for further elucidating the immune functions of channel catfish CD156a are under development. ..
  48. Shukla S, Ablack A, Wen A, Lee K, Lewis J, Steinmetz N. Increased tumor homing and tissue penetration of the filamentous plant viral nanoparticle Potato virus X. Mol Pharm. 2013;10:33-42 pubmed publisher
    ..The enhanced tumor homing and retention properties of PVX along with its higher payload carrying capacity make it a potentially superior platform for applications in cancer drug delivery and imaging applications. ..
  49. Kostich W, Chen A, Sperle K, Largent B. Molecular identification and analysis of a novel human corticotropin-releasing factor (CRF) receptor: the CRF2gamma receptor. Mol Endocrinol. 1998;12:1077-85 pubmed
    ..Analysis of CRF2gamma RNA expression in human brain demonstrates expression in septum and hippocampus, with weaker but detectable expression in amygdala, nucleus accumbens, midbrain, and frontal cortex. ..
  50. Ma H, Fukiage C, Kim Y, Duncan M, Reed N, Shih M, et al. Characterization and expression of calpain 10. A novel ubiquitous calpain with nuclear localization. J Biol Chem. 2001;276:28525-31 pubmed
    ..In conclusion, calpain 10 seems to be a ubiquitous calpain, the expression level and subcellular distribution of which are dynamically influenced by calcium. ..
  51. Dumont R, Zhao Y, Holt J, Bähler M, Gillespie P. Myosin-I isozymes in neonatal rodent auditory and vestibular epithelia. J Assoc Res Otolaryngol. 2002;3:375-89 pubmed
    ..Myo1c therefore remains the myosin isozyme best localized to carry out transducer adaptation. ..
  52. Frydman B, Porter C, Maxuitenko Y, Sarkar A, Bhattacharya S, Valasinas A, et al. A novel polyamine analog (SL-11093) inhibits growth of human prostate tumor xenografts in nude mice. Cancer Chemother Pharmacol. 2003;51:488-92 pubmed
    ..We tested the polyamine analog SL-11093 (3,8,13,18-tetraaza-10,11-[(E)-1,2-cyclopropyl]eicosane tetrahydrochloride) as an effective chemotherapeutic agent against human prostate cancer grown in nude mice...
  53. Kucia M, Wojakowski W, Reca R, Machalinski B, Gozdzik J, Majka M, et al. The migration of bone marrow-derived non-hematopoietic tissue-committed stem cells is regulated in an SDF-1-, HGF-, and LIF-dependent manner. Arch Immunol Ther Exp (Warsz). 2006;54:121-35 pubmed
  54. Ganapathy V, Thangaraju M, Gopal E, Martin P, Itagaki S, Miyauchi S, et al. Sodium-coupled monocarboxylate transporters in normal tissues and in cancer. AAPS J. 2008;10:193-9 pubmed publisher
    ..These drugs are not transportable substrates for SLC5A8, but instead function as blockers of the transporter. Relatively less is known on the role of SLC5A12 in drug transport. ..
  55. Cai S, Xie Y, Bagby T, Cohen M, Forrest M. Intralymphatic chemotherapy using a hyaluronan-cisplatin conjugate. J Surg Res. 2008;147:247-52 pubmed publisher
    ..Further in vivo testing related to efficacy of this approach with regard to survival, toxicity, and pharmacokinetics is warranted to support its use in human trials. ..
  56. Bei D, An G. Pharmacokinetics and tissue distribution of 5,7-dimethoxyflavone in mice following single dose oral administration. J Pharm Biomed Anal. 2016;119:65-70 pubmed publisher
    ..65 to 12.9. In conclusion, we reported for the first time the PK and tissue distribution of 5,7-DMF in mice. These results will be critical in evaluating if those beneficial in vitro effects can be translated in vivo. ..
  57. Cho K, Wall J, Pugh P, Ito M, Mueller S, Kennedy M. The alpha subunit of type II Ca2+/calmodulin-dependent protein kinase is highly conserved in Drosophila. Neuron. 1991;7:439-50 pubmed
    ..The protein product of this gene is expressed at much higher levels in the fly head than in the body. Thus, both the amino acid sequence and the tissue specificity of the mammalian kinase are highly conserved in Drosophila. ..
  58. Tole S, Patterson P. Regionalization of the developing forebrain: a comparison of FORSE-1, Dlx-2, and BF-1. J Neurosci. 1995;15:970-80 pubmed
  59. Rosenfeld C, Ganjam V, Taylor J, Yuan X, Stiehr J, Hardy M, et al. Transcription and translation of estrogen receptor-beta in the male reproductive tract of estrogen receptor-alpha knock-out and wild-type mice. Endocrinology. 1998;139:2982-7 pubmed
  60. Darcy K, Zangani D, Wohlhueter A, Huang R, Vaughan M, Russell J, et al. Changes in ErbB2 (her-2/neu), ErbB3, and ErbB4 during growth, differentiation, and apoptosis of normal rat mammary epithelial cells. J Histochem Cytochem. 2000;48:63-80 pubmed
    ..Finally, ErbB4 expression did not interfere with functional differentiation and apoptosis of normal MECs. ..
  61. Pi X, Voogt J. Effect of suckling on prolactin receptor immunoreactivity in the hypothalamus of the rat. Neuroendocrinology. 2000;71:308-17 pubmed
    ..PRL receptors in those nuclei which were significantly altered by suckling stimulus may play more critical roles during lactation than those areas which were less sensitive to the suckling stimulus. ..
  62. Mitchell G, Cook K, Jenkins M, Grundel E. Supplementation of rats with a lutein mixture preserved with vitamin E reduces tissue phylloquinone and menaquinone-4. Int J Vitam Nutr Res. 2001;71:30-5 pubmed
    ..The presence of other components in the supplement confounded the interpretation of the biological effects of lutein alone on vitamin K metabolism. ..
  63. Holicky E, Hadac E, Ding X, Miller L. Molecular characterization and organ distribution of type A and B cholecystokinin receptors in cynomolgus monkey. Am J Physiol Gastrointest Liver Physiol. 2001;281:G507-14 pubmed
    ..This work confirms the relevance of the cynomolgus species for preclinical testing of drugs acting on the type A CCK receptor. ..
  64. Berggren K, Ezerman E, McCaffery P, Forehand C. Expression and regulation of the retinoic acid synthetic enzyme RALDH-2 in the embryonic chicken wing. Dev Dyn. 2001;222:1-16 pubmed
  65. Li Q, Wang C, Shi J, Ruan Q, Eckenrode S, Davoodi Semiromi A, et al. Molecular cloning and characterization of the mouse and human TUSP gene, a novel member of the tubby superfamily. Gene. 2001;273:275-84 pubmed
  66. de l, Brunner M, Eichler H, Rehak E, Gross J, Thyroff Friesinger U, et al. Comparative target site pharmacokinetics of immediate- and modified-release formulations of cefaclor in humans. J Clin Pharmacol. 2002;42:403-11 pubmed
    ..The data of the present study indicate that time above MIC values at the target site can be substantially prolonged if an antibiotic is administered as a sustained-release product. ..
  67. Lee K, Dabrowski K. Gossypol and gossypolone enantiomers in tissues of rainbow trout fed low and high levels of dietary cottonseed meal. J Agric Food Chem. 2002;50:3056-61 pubmed
  68. Zhu C, Liu Q, Ramanujam N. Effect of fiber optic probe geometry on depth-resolved fluorescence measurements from epithelial tissues: a Monte Carlo simulation. J Biomed Opt. 2003;8:237-47 pubmed
    ..The simulation results are used to design a simple fiber optic probe that combines both the VA and MD geometries to enable fluorescence measurements from the different sublayers within human epithelial tissues. ..
  69. Cao Z, Tanguay R, McKenzie D, Peterson R, Aiken J. Identification of a putative calcium-binding protein as a dioxin-responsive gene in zebrafish and rainbow trout. Aquat Toxicol. 2003;63:271-82 pubmed
    ..However, demonstration that the encoded S100A4 proteins actually bind calcium and play a role in dioxin toxicity will require further study. ..
  70. Seward D, Koh A, Boyer J, Ballatori N. Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta. J Biol Chem. 2003;278:27473-82 pubmed
    ..Interestingly, OSTalpha and OSTbeta mRNAs were highly expressed and widely distributed in human tissues, with the highest levels occurring in the testis, colon, liver, small intestine, kidney, ovary, and adrenal gland. ..
  71. Ersahin C, Szpaderska A, Simmons W. Rat and mouse membrane aminopeptidase P: structure analysis and tissue distribution. Arch Biochem Biophys. 2003;417:131-40 pubmed
    ..The tissue-specific expression of mAPP was studied using the polymerase chain reaction. The mAPP gene is widely, but variably, expressed in adult tissues of the rat and mouse and in mouse embryos. ..
  72. Hu Y, Riesland L, Paterson A, Kudlow J. Phosphorylation of mouse glutamine-fructose-6-phosphate amidotransferase 2 (GFAT2) by cAMP-dependent protein kinase increases the enzyme activity. J Biol Chem. 2004;279:29988-93 pubmed
    ..GFAT2 is, therefore, an isoenzyme of GFAT1, but its regulation by cAMP is the opposite, allowing differential regulation of the hexosamine pathway in specialized tissues. ..
  73. Zhao X, Schneider D, Biroc S, Parry R, Alicke B, Toy P, et al. Targeting tomoregulin for radioimmunotherapy of prostate cancer. Cancer Res. 2005;65:2846-53 pubmed
    ..Our data clearly validate tomoregulin as a target for radioimmunotherapy of prostate cancer. ..
  74. Wood C. Cerebral hypoperfusion increases estrogen receptor abundance in the ovine fetal brain and pituitary. Neuroendocrinology. 2008;87:216-22 pubmed
    ..We conclude that the expression of ER-alpha and ER-beta in the brain and pituitary of fetal sheep are influenced by circulating estrogen concentrations and acutely regulated in response to cerebral hypoperfusion. ..
  75. Contreras M, Haq E, Uto T, Singh I, Singh A. Psychosine-induced alterations in peroxisomes of twitcher mouse liver. Arch Biochem Biophys. 2008;477:211-8 pubmed publisher
    ..These observations indicate that twitcher mouse pathobiology extends to the liver, where psychosine-induced TNF-alpha and IL-6 compromise peroxisomal structure and functions. ..
  76. Ugalde C, Liu Z, Ren C, Chan K, Rodrigo K, Ling Y, et al. Distribution of anthocyanins delivered from a bioadhesive black raspberry gel following topical intraoral application in normal healthy volunteers. Pharm Res. 2009;26:977-86 pubmed publisher
    ..Our data, which demonstrate a local delivery-derived pharmacologic advantage, provide insights which could advance oral cavity chemoprevention strategies. ..
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