Experts and Doctors on time factors in United Kingdom


Locale: United Kingdom
Topic: time factors

Top Publications

  1. Jones J, Hench L. Factors affecting the structure and properties of bioactive foam scaffolds for tissue engineering. J Biomed Mater Res B Appl Biomater. 2004;68:36-44 pubmed
    ..The in vitro dissolution and bioactivity of the bioactive foams were compared to that of unfoamed monoliths and powders (< 20 microm in diameter) of the same composition...
  2. Collins B, Dissel S, Gaten E, Rosato E, Kyriacou C. Disruption of Cryptochrome partially restores circadian rhythmicity to the arrhythmic period mutant of Drosophila. Proc Natl Acad Sci U S A. 2005;102:19021-6 pubmed
    ..Although we do not yet have a molecular correlate for these apparently iconoclastic observations, we provide a systems explanation for these results based on differential sensitivities of subsets of circadian pacemaker neurons to light. ..
  3. Domike K, Donald A. Kinetics of spherulite formation and growth: salt and protein concentration dependence on proteins beta-lactoglobulin and insulin. Int J Biol Macromol. 2009;44:301-10 pubmed
  4. Pepe A, Xiao Q, Zampetaki A, Zhang Z, Kobayashi A, Hu Y, et al. Crucial role of nrf3 in smooth muscle cell differentiation from stem cells. Circ Res. 2010;106:870-9 pubmed publisher
  5. Barker G, Warburton E. When is the hippocampus involved in recognition memory?. J Neurosci. 2011;31:10721-31 pubmed publisher
    ..Thus, the hippocampus plays a role in recognition memory when such memory involves remembering that a particular stimulus occurred in a particular place or when the memory contains a temporal or object recency component. ..
  6. Brimijoin W, Akeroyd M, Tilbury E, Porr B. The internal representation of vowel spectra investigated using behavioral response-triggered averaging. J Acoust Soc Am. 2013;133:EL118-22 pubmed publisher
    ..The success of this response-triggered technique suggests that it may prove useful for estimating other internal representations, including perceptual phenomena like tinnitus. ..
  7. Nicosia V, Vértes P, Schafer W, Latora V, Bullmore E. Phase transition in the economically modeled growth of a cellular nervous system. Proc Natl Acad Sci U S A. 2013;110:7880-5 pubmed publisher
    ..We expect that similar economical principles may be found in the development of other biological or manmade spatially embedded complex systems. ..
  8. Hayward G, Hay A, Moore M, Jawad S, Williams N, Voysey M, et al. Effect of Oral Dexamethasone Without Immediate Antibiotics vs Placebo on Acute Sore Throat in Adults: A Randomized Clinical Trial. JAMA. 2017;317:1535-1543 pubmed publisher
    ..Acute sore throat poses a significant burden on primary care and is a source of inappropriate antibiotic prescribing. Corticosteroids could be an alternative symptomatic treatment...
  9. Song D, Ashcroft F. ATP modulation of ATP-sensitive potassium channel ATP sensitivity varies with the type of SUR subunit. J Biol Chem. 2001;276:7143-9 pubmed
    ..This suggests that MgATP may cause disruption of the cytoskeleton, leading to enhanced membrane phospholipid levels (or better targeting to the K(ATP) channel) and thus to decreased channel ATP sensitivity. ..

More Information

Publications704 found, 100 shown here

  1. Suk J, Jensen S, McGettrick A, Willis A, Whiteman P, Redfield C, et al. Structural consequences of cysteine substitutions C1977Y and C1977R in calcium-binding epidermal growth factor-like domain 30 of human fibrillin-1. J Biol Chem. 2004;279:51258-65 pubmed
    ..This proposed structural heterogeneity may underlie the observed differences in stability and cellular trafficking of proteins containing such changes. ..
  2. Hilton J, O Hare M, Bowes M, Jones J. How green is my river? A new paradigm of eutrophication in rivers. Sci Total Environ. 2006;365:66-83 pubmed
    ..The implications of this conceptual model are discussed and a series of observable effects are predicted, which should result if the model is correct. ..
  3. Schonrogge K, Begg T, Stone G. Native birds and alien insects: spatial density dependence in songbird predation of invading oak gallwasps. PLoS ONE. 2013;8:e53959 pubmed publisher
    ..We hypothesise that this pattern results from the time taken for native bird populations to learn how to exploit this novel resource. ..
  4. McNamara A, Adamson A, Dunham L, Semprini S, Spiller D, McNeilly A, et al. Role of Estrogen Response Element in the Human Prolactin Gene: Transcriptional Response and Timing. Mol Endocrinol. 2016;30:189-200 pubmed publisher
    ..These data suggest the -1189 ERE is the dominant response element involved in the hPRL transcriptional response to both E2 and TNFα and, crucially, that cycles of hPRL promoter activity are independent of estrogen receptor binding. ..
  5. Lange J, Metzner C, Richter S, Schneider W, Spermann M, Kolb T, et al. Unbiased High-Precision Cell Mechanical Measurements with Microconstrictions. Biophys J. 2017;112:1472-1480 pubmed publisher
  6. Gibson K, Eggeling L, Maughan W, Krumbach K, Gurcha S, Nigou J, et al. Disruption of Cg-Ppm1, a polyprenyl monophosphomannose synthase, and the generation of lipoglycan-less mutants in Corynebacterium glutamicum. J Biol Chem. 2003;278:40842-50 pubmed
    ..Lipoglycans are important immunomodulatory molecules involved in determining the outcome of infection, and so the generation of defined mutants and their subsequent immunological characterization is timely. ..
  7. Healy J, Menges M, Doonan J, Murray J. The Arabidopsis D-type cyclins CycD2 and CycD3 both interact in vivo with the PSTAIRE cyclin-dependent kinase Cdc2a but are differentially controlled. J Biol Chem. 2001;276:7041-7 pubmed
    ..CycD2 kinase activity is regulated by sequestration of CycD2 protein in a form inaccessible to immunoprecipitation and probably not complexed to Cdc2a. ..
  8. Mann J, Oakley F, Johnson P, Mann D. CD40 induces interleukin-6 gene transcription in dendritic cells: regulation by TRAF2, AP-1, NF-kappa B, AND CBF1. J Biol Chem. 2002;277:17125-38 pubmed
    ..The physiological relevance of these molecular events to DC function is discussed. ..
  9. Su Y, Bakker T, Harris J, Tsang C, Brown G, Wormald M, et al. Glycosylation influences the lectin activities of the macrophage mannose receptor. J Biol Chem. 2005;280:32811-20 pubmed
    ..i) It is required for mannose recognition; and (ii) it modulates the tendency of MR to self-associate, effectively regulating the avidity of the CR domain for sulfated sugar ligands. ..
  10. Tyson Capper A, Bailey J, Krainer A, Robson S, Europe Finner G. The switch in alternative splicing of cyclic AMP-response element modulator protein CREM{tau}2{alpha} (activator) to CREM{alpha} (repressor) in human myometrial cells is mediated by SRp40. J Biol Chem. 2005;280:34521-9 pubmed
  11. Moiseeva E, Almeida G, Jones G, Manson M. Extended treatment with physiologic concentrations of dietary phytochemicals results in altered gene expression, reduced growth, and apoptosis of cancer cells. Mol Cancer Ther. 2007;6:3071-9 pubmed
    ..This model has revealed that apoptosis and not arrest is likely to be responsible for growth inhibition. It also implicated new molecular targets and activities of the agents under conditions relevant to human exposure. ..
  12. Wiseman V, Scott A, Conteh L, McElroy B, Stevens W. Determinants of provider choice for malaria treatment: experiences from The Gambia. Soc Sci Med. 2008;67:487-96 pubmed publisher
    ..Poorer households and those from the Fula ethnic group were much more likely to visit an 'other' provider than a hospital. The policy and methodological implications of these findings are discussed. ..
  13. Turner A, Singh N, Millard L. Bioaccessibility and bioavailability of Cu and Zn in sediment contaminated by antifouling paint residues. Environ Sci Technol. 2008;42:8740-6 pubmed
    ..The findings of this study have important implications regarding the cycling of trace metals in coastal waters impacted by boating activities. ..
  14. Fuller W, Howie J, McLatchie L, Weber R, Hastie C, Burness K, et al. FXYD1 phosphorylation in vitro and in adult rat cardiac myocytes: threonine 69 is a novel substrate for protein kinase C. Am J Physiol Cell Physiol. 2009;296:C1346-55 pubmed publisher
    ..We conclude that T69 is a previously undescribed phosphorylation site in FXYD1. Acute T69 phosphorylation elicits stimulation of the sodium pump additional to that induced by S63 and S68 phosphorylation. ..
  15. Findlow H, Borrow R, Hardelid P, Newton E, Frankland S, Naylor S, et al. Serum antibody kinetics following nasal or parenteral challenge with meningococcal polysaccharide in healthy adults. Clin Vaccine Immunol. 2011;18:424-9 pubmed publisher
  16. Lopez Vernaza M, Yang S, Muller R, Thorpe F, de Leau E, Goodrich J. Antagonistic roles of SEPALLATA3, FT and FLC genes as targets of the polycomb group gene CURLY LEAF. PLoS ONE. 2012;7:e30715 pubmed publisher
    ..We conclude that SEP3 is the key target mediating the clf phenotype, and that the antagonistic effects of CLF target genes masks a role for CLF in promoting flowering. ..
  17. Volkmann K, Pfander C, Burstroem C, Ahras M, Goulding D, Rayner J, et al. The alveolin IMC1h is required for normal ookinete and sporozoite motility behaviour and host colonisation in Plasmodium berghei. PLoS ONE. 2012;7:e41409 pubmed publisher
    ..Together, these results suggest that IMC1h is involved in maintaining the cellular architecture which supports normal motility behaviour, access of the sporozoites to the blood stream, and further colonisation of the mammalian host...
  18. Vossel S, Weidner R, Driver J, Friston K, Fink G. Deconstructing the architecture of dorsal and ventral attention systems with dynamic causal modeling. J Neurosci. 2012;32:10637-48 pubmed publisher
  19. Stacey D, Bilbao A, Maroteaux M, Jia T, Easton A, Longueville S, et al. RASGRF2 regulates alcohol-induced reinforcement by influencing mesolimbic dopamine neuron activity and dopamine release. Proc Natl Acad Sci U S A. 2012;109:21128-33 pubmed publisher
    ..Together, these combined animal and human data indicate a role for RASGRF2 in the regulation of mesolimbic dopamine neuron activity, reward response, and alcohol use and abuse. ..
  20. Amaniti E, Hasenpusch Theil K, Li Z, Magnani D, Kessaris N, Mason J, et al. Gli3 is required in Emx1+ progenitors for the development of the corpus callosum. Dev Biol. 2013;376:113-24 pubmed publisher
    ..Collectively, these data demonstrate a crucial role for Gli3 in cortical progenitors to control CC formation and indicate how defects in CSB formation affect the positioning of callosal guidepost cells. ..
  21. Alison L, Doran B, Long M, Power N, HUMPHREY A. The effects of subjective time pressure and individual differences on hypotheses generation and action prioritization in police investigations. J Exp Psychol Appl. 2013;19:83-93 pubmed publisher
    ..Experience had no effect on time pressure during the investigative scenario. Implications of these findings are discussed. ..
  22. Baskaran M, Yang E, Trikha S, Kumar R, Wong H, He M, et al. Residual Angle Closure One Year After Laser Peripheral Iridotomy in Primary Angle Closure Suspects. Am J Ophthalmol. 2017;183:111-117 pubmed publisher
    ..One year after LPI, >80% of PACS had gonioscopic residual angle closure. Greater baseline iris volume and higher IOP at baseline are independent risk factors for residual gonioscopic angle closure. ..
  23. Abdul Tehrani H, Hudson A, Chang Y, Timms A, Hawkins C, Williams J, et al. Ferritin mutants of Escherichia coli are iron deficient and growth impaired, and fur mutants are iron deficient. J Bacteriol. 1999;181:1415-28 pubmed
    ..In addition to repressing the iron acquisition systems, Fur appears to regulate the demand for iron, probably by controlling the expression of iron-containing proteins. The role of Bfr remains unclear. ..
  24. Clements J, Beckett R, Brown A, Catlin G, Lobell M, Palan S, et al. Antibiotic activity and characterization of BB-3497, a novel peptide deformylase inhibitor. Antimicrob Agents Chemother. 2001;45:563-70 pubmed
    ..aureus protected mice from infection with median effective doses of 8 and 14 mg/kg of body weight, respectively. These data validate PDF as a novel target for the design of a new generation of antibacterial agents. ..
  25. Murray J, Kurtis C, Tambyrajah W, Saysell C, Wilmot C, Parsons M, et al. Conserved tyrosine-369 in the active site of Escherichia coli copper amine oxidase is not essential. Biochemistry. 2001;40:12808-18 pubmed
    ..The moderate changes in kinetic parameters observed for the Y369F variant indicate that if this is the case, then the absence of the Tyr369 hydroxyl can be compensated for efficiently within the active site. ..
  26. Orchiston E, Bennett D, Leslie N, Clarke R, Winward L, Downes C, et al. PTEN M-CBR3, a versatile and selective regulator of inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5). Evidence for Ins(1,3,4,5,6)P5 as a proliferative signal. J Biol Chem. 2004;279:1116-22 pubmed
    ..Our results, together with previously published data, suggest that Ins(1,3,4,5,6)P5 has a role in proliferation. ..
  27. Grubb M, Thompson I. Visual response properties in the dorsal lateral geniculate nucleus of mice lacking the beta2 subunit of the nicotinic acetylcholine receptor. J Neurosci. 2004;24:8459-69 pubmed
  28. Roberts M, Stober C, McKenzie A, Blackwell J. Interleukin-4 (IL-4) and IL-10 collude in vaccine failure for novel exacerbatory antigens in murine Leishmania major infection. Infect Immun. 2005;73:7620-8 pubmed
    ..major, while having an intrinsic capacity to exacerbate disease in the context of otherwise T helper 1-promoting DNA vaccine delivery, can be rendered protective by the removal of functional IL-10. ..
  29. Spencer M, Casson S, Lindsey K. Transcriptional profiling of the Arabidopsis embryo. Plant Physiol. 2007;143:924-40 pubmed
    ..We show how identified genes can be used to generate cell type-specific markers and promoter activities for future application in cell biology. ..
  30. Maughan R, Shirreffs S, Watson P. Exercise, heat, hydration and the brain. J Am Coll Nutr. 2007;26:604S-612S pubmed
    ..Recent evidence suggests that the integrity of the blood brain barrier may be compromised by combined heat stress and dehydration, and this may play a role in limiting performance in the heat. ..
  31. Mallet N, Pogosyan A, Sharott A, Csicsvari J, Bolam J, Brown P, et al. Disrupted dopamine transmission and the emergence of exaggerated beta oscillations in subthalamic nucleus and cerebral cortex. J Neurosci. 2008;28:4795-806 pubmed publisher
    ..Targeting the plastic processes underlying the delayed emergence of pathological beta oscillations after continuing dopaminergic dysfunction may offer considerable therapeutic promise. ..
  32. Bee L, Dickenson A. Effects of lacosamide, a novel sodium channel modulator, on dorsal horn neuronal responses in a rat model of neuropathy. Neuropharmacology. 2009;57:472-9 pubmed publisher
  33. Thompson G, Barbir M, Davies D, Dobral P, Gesinde M, Livingston M, et al. Efficacy criteria and cholesterol targets for LDL apheresis. Atherosclerosis. 2010;208:317-21 pubmed publisher
    ..Establishing a uniform approach to data collection would facilitate the setting up of national or multi-national registers and might eventually provide the information needed to formulate evidence-based guidelines for LDL apheresis. ..
  34. Jama A, Fenton J, Robertson S, Torok K. Time-dependent autoinactivation of phospho-Thr286-alphaCa2+/calmodulin-dependent protein kinase II. J Biol Chem. 2009;284:28146-55 pubmed publisher
  35. Lavandier M, Culling J. Prediction of binaural speech intelligibility against noise in rooms. J Acoust Soc Am. 2010;127:387-99 pubmed publisher
    ..These parameters were all calculated from the room impulse responses convolved with noise. A 0.95-0.97 correlation was obtained between the speech reception thresholds and their predicted value. ..
  36. Selvadurai H, Mason J. Wnt/β-catenin signalling is active in a highly dynamic pattern during development of the mouse cerebellum. PLoS ONE. 2011;6:e23012 pubmed publisher
    ..These results indicate a variety of potential functions for Wnt/β-catenin activity during cerebellum development. ..
  37. Al Aqaba M, Otri A, Fares U, Miri A, Dua H. Organization of the regenerated nerves in human corneal grafts. Am J Ophthalmol. 2012;153:29-37.e4 pubmed publisher
    ..A persistent anatomic disorganization of the corneal nerves in human grafts was found even 14 years after surgery. This could explain the significant reduction of corneal sensation reported in previous studies. ..
  38. Silva A, Cordeiro da Silva A, Coombs G. Metabolic variation during development in culture of Leishmania donovani promastigotes. PLoS Negl Trop Dis. 2011;5:e1451 pubmed publisher
    ..Most notable were the structural changes in glycerophospholipids and increase in the abundance of sphingolipids and glycerolipids as cells progress from logarithmic to stationary phase. ..
  39. Smith S, Miller K, Moeller S, Xu J, Auerbach E, Woolrich M, et al. Temporally-independent functional modes of spontaneous brain activity. Proc Natl Acad Sci U S A. 2012;109:3131-6 pubmed publisher
    ..These functionally distinct modes of spontaneous brain activity are, in general, quite different from resting-state networks previously reported, and may have greater biological interpretability. ..
  40. Trauner A, Lougheed K, Bennett M, Hingley Wilson S, Williams H. The dormancy regulator DosR controls ribosome stability in hypoxic mycobacteria. J Biol Chem. 2012;287:24053-63 pubmed publisher
    ..We suggest that this protein is named ribosome-associated factor under hypoxia (RafH) and that it is the major factor responsible for DosR-mediated hypoxic survival in mycobacteria. ..
  41. Liu W, Schat H, Bliek M, Chen Y, McGrath S, GEORGE G, et al. Knocking out ACR2 does not affect arsenic redox status in Arabidopsis thaliana: implications for as detoxification and accumulation in plants. PLoS ONE. 2012;7:e42408 pubmed publisher
    ..Our results suggest the existence of multiple pathways of arsenate reduction in plants and yeast. ..
  42. Eisma R, Lamb C, Soames R. From formalin to Thiel embalming: What changes? One anatomy department's experiences. Clin Anat. 2013;26:564-71 pubmed publisher
    ..This has resulted in new collaborations and research projects. As a result Thiel-embalmed cadavers are used for longer and for more activities than formalin cadavers: this requires changes in our procedures and staff roles. ..
  43. Pavlov I, Savtchenko L, Song I, Koo J, Pimashkin A, Rusakov D, et al. Tonic GABAA conductance bidirectionally controls interneuron firing pattern and synchronization in the CA3 hippocampal network. Proc Natl Acad Sci U S A. 2014;111:504-9 pubmed publisher
    ..Thus, our observations suggest that tonic GABAA conductance can bidirectionally control brain rhythms through changes in the excitability of interneurons and in the temporal structure of their firing patterns. ..
  44. Kayser S, McNair S, Kayser C. Prestimulus influences on auditory perception from sensory representations and decision processes. Proc Natl Acad Sci U S A. 2016;113:4842-7 pubmed publisher
    ..These results delineate two consistent mechanisms by which prestimulus activity shapes perception. However, the timescales of the relevant neural activity depend on the specific brain regions engaged by the respective task. ..
  45. Callow M, Callow J, Ista L, Coleman S, Nolasco A, Lopez G. Use of self-assembled monolayers of different wettabilities to study surface selection and primary adhesion processes of green algal (Enteromorpha) zoospores. Appl Environ Microbiol. 2000;66:3249-54 pubmed
    ..The results are discussed in relation to the attachment of microorganisms to substrata having different wettabilities. ..
  46. Koivisto P, Robins P, Lindahl T, Sedgwick B. Demethylation of 3-methylthymine in DNA by bacterial and human DNA dioxygenases. J Biol Chem. 2004;279:40470-4 pubmed
    ..Our data suggest that 3-methylthymine residues in DNA will be repaired inefficiently in vivo and therefore may occur at a low steady-state level, but the residues should not gradually accumulate to high levels in long lived cells. ..
  47. Thompson S, Wadhams G, Armitage J. The positioning of cytoplasmic protein clusters in bacteria. Proc Natl Acad Sci U S A. 2006;103:8209-14 pubmed
    ..These data suggest that there is a mechanism involved in partitioning some cytoplasmic proteins upon cell division that is analogous to a mechanism seen for plasmid and chromosomal DNA. ..
  48. Cole L, Heard C. Skin permeation enhancement potential of Aloe Vera and a proposed mechanism of action based upon size exclusion and pull effect. Int J Pharm. 2007;333:10-6 pubmed
    ..A new mechanistic rationale is proposed whereby larger drug solutes inhibit the permeation of Aloe Vera components, but also are then able to interact more effectively with the enhancing factor and be subject to the pull effect. ..
  49. Filatov D, Howell E, Groutides C, Armstrong S. Recent spread of a retrotransposon in the Silene latifolia genome, apart from the Y chromosome. Genetics. 2009;181:811-7 pubmed publisher
    ..This coincided with the latest steps of sex chromosome evolution in this species...
  50. Dehghani H, Davis S, Pogue B. Spectrally resolved bioluminescence tomography using the reciprocity approach. Med Phys. 2008;35:4863-71 pubmed
    ..75 h. ..
  51. Cooke E, Tallis R, Clark A, Pomeroy V. Efficacy of functional strength training on restoration of lower-limb motor function early after stroke: phase I randomized controlled trial. Neurorehabil Neural Repair. 2010;24:88-96 pubmed publisher
    ..No significant differences were observed for torque about the knee or for the Rivermead score. At follow-up, no significant differences were observed. These phase I results justify a subsequent trial of CPT + CPT versus CPT + FST. ..
  52. Hawkes L, Balachandran S, Batbayar N, Butler P, Frappell P, Milsom W, et al. The trans-Himalayan flights of bar-headed geese (Anser indicus). Proc Natl Acad Sci U S A. 2011;108:9516-9 pubmed publisher
    ..It would seem, therefore, that bar-headed geese are capable of sustained climbing flight over the passes of the Himalaya under their own aerobic power...
  53. Jago R, Stamatakis E, Gama A, Carvalhal I, Nogueira H, Rosado V, et al. Parent and child screen-viewing time and home media environment. Am J Prev Med. 2012;43:150-8 pubmed publisher
    ..Parental TV-viewing time was associated with Portuguese children's TV-viewing time. The numbers of TVs in the household and electronic games equipment access were also associated with TV- and combined other media-viewing/usage time. ..
  54. Freh F, Chung M, Dallos R. In the shadow of terror: posttraumatic stress and psychiatric co-morbidity following bombing in Iraq: the role of shattered world assumptions and altered self-capacities. J Psychiatr Res. 2013;47:215-25 pubmed publisher
    ..Civilians' perceptions of their ability to control events in the world and regulate their affect had a short term impact on the severity of these symptoms. ..
  55. Pan Y, Liu S, Yeh L. Factors affecting early attrition and later treatment course of antidepressant treatment of depression in naturalistic settings: an 18-month nationwide population-based study. J Psychiatr Res. 2013;47:916-25 pubmed publisher
    ..Early attrition needs to be minimized through shared decision-making, exchange of treatment preferences and proper patient-physician communication. ..
  56. Opie C, Atkinson Q, Dunbar R, Shultz S. Male infanticide leads to social monogamy in primates. Proc Natl Acad Sci U S A. 2013;110:13328-32 pubmed publisher
    ..These phylogenetic analyses support a key role for infanticide in the social evolution of primates, and potentially, humans. ..
  57. Neher J, Emmrich J, Fricker M, Mander P, Thery C, Brown G. Phagocytosis executes delayed neuronal death after focal brain ischemia. Proc Natl Acad Sci U S A. 2013;110:E4098-107 pubmed publisher
    ..Therefore, inhibition of specific phagocytic pathways may present therapeutic targets for preventing delayed neuronal loss after transient cerebral ischemia. ..
  58. Aitken A, Giese D, Tsoumpas C, Schleyer P, Kozerke S, Prieto C, et al. Improved UTE-based attenuation correction for cranial PET-MR using dynamic magnetic field monitoring. Med Phys. 2014;41:012302 pubmed publisher
    ..This improves the accuracy of segmented PET attenuation maps derived from UTE sequences and subsequent PET reconstruction. ..
  59. Mountain G, Windle G, Hind D, Walters S, Keertharuth A, Chatters R, et al. A preventative lifestyle intervention for older adults (lifestyle matters): a randomised controlled trial. Age Ageing. 2017;46:627-634 pubmed publisher
    ..The results pose questions regarding how preventive interventions to promote well-being in older adults can be effectively targeted in the absence of proactive mechanisms to identify those who at risk of decline. ISRCTN67209155. ..
  60. Bienemann A, Martin Rendon E, Cosgrave A, Glover C, Wong L, Kingsman S, et al. Long-term replacement of a mutated nonfunctional CNS gene: reversal of hypothalamic diabetes insipidus using an EIAV-based lentiviral vector expressing arginine vasopressin. Mol Ther. 2003;7:588-96 pubmed
    ..This study highlights the potential of using viral gene therapy for the long-term treatment of disorders of the CNS. ..
  61. Davies C, Mason J, Wakelam M, Young L, Eliopoulos A. Inhibition of phosphatidylinositol 3-kinase- and ERK MAPK-regulated protein synthesis reveals the pro-apoptotic properties of CD40 ligation in carcinoma cells. J Biol Chem. 2004;279:1010-9 pubmed
    ..Pharmacological agents that target this machinery or its upstream kinases could, therefore, be exploited for CD40-based tumor therapy. ..
  62. Deol S, Domene C, Bond P, Sansom M. Anionic phospholipid interactions with the potassium channel KcsA: simulation studies. Biophys J. 2006;90:822-30 pubmed publisher
    ..Overall, this study suggests that simulations can help identify and characterize sites for specific lipid interactions on a membrane protein surface...
  63. Andolina I, Jones H, Wang W, Sillito A. Corticothalamic feedback enhances stimulus response precision in the visual system. Proc Natl Acad Sci U S A. 2007;104:1685-90 pubmed
    ..We discuss the significance of these data for cortical function and suggest that the precision in stimulus-linked firing in the LGN appears as an emergent factor from the corticothalamic interaction. ..
  64. Devbhandari M, Quennell P, Krysiak P, Shah R, Jones M. Implications of a negative bronchoscopy on waiting times to treatment for lung cancer patients: results of a prospective tracking study. Eur J Cardiothorac Surg. 2008;34:479-83 pubmed publisher
    ..Most of the delay occurs in the interval from the outpatient appointment to decision-to-treat. Patients with negative bronchoscopy require a more concerted effort to achieve a timely diagnosis and treatment. ..
  65. Bishop T, Ballard A, Holmes H, Young A, McMahon S. Ultraviolet-B induced inflammation of human skin: characterisation and comparison with traditional models of hyperalgesia. Eur J Pain. 2009;13:524-32 pubmed publisher
    ..Taken together these findings suggest that UVB inflammation, at least using moderate doses produces sensory changes primarily by sensitising peripheral pain processing in the relative absence of alterations in central pain processing. ..
  66. Natan E, Hirschberg D, Morgner N, Robinson C, Fersht A. Ultraslow oligomerization equilibria of p53 and its implications. Proc Natl Acad Sci U S A. 2009;106:14327-32 pubmed publisher
    ..The slow oligomerization of free p53, competing with spontaneous denaturation, has implications for the possible regulation of p53 by binding proteins and DNA that affect tetramerization kinetics as well as equilibria. ..
  67. Gibson P, Burns J, Walker H, Cross S, Leslie S. Keeping track of congenital heart disease--is it time for a national registry?. Int J Cardiol. 2010;145:331-332 pubmed publisher
  68. Durham S, Emminger W, Kapp A, Colombo G, de Monchy J, Rak S, et al. Long-term clinical efficacy in grass pollen-induced rhinoconjunctivitis after treatment with SQ-standardized grass allergy immunotherapy tablet. J Allergy Clin Immunol. 2010;125:131-8.e1-7 pubmed publisher
  69. Hutchins G, Southward K, Handley K, Magill L, Beaumont C, Stahlschmidt J, et al. Value of mismatch repair, KRAS, and BRAF mutations in predicting recurrence and benefits from chemotherapy in colorectal cancer. J Clin Oncol. 2011;29:1261-70 pubmed publisher
    ..MMR assays identify patients with a low risk of recurrence. KRAS mutational analysis provides useful additional risk stratification to guide use of chemotherapy. ..
  70. Jackson D, Wang X, Rudner D. Spatio-temporal organization of replication in bacteria and eukaryotes (nucleoids and nuclei). Cold Spring Harb Perspect Biol. 2012;4:a010389 pubmed publisher
    ..We will then discuss spatial and temporal organization of replication in eukaryotes highlighting the similarities and differences between these two domains of life. ..
  71. Dumaz N, Marais R. Protein kinase A blocks Raf-1 activity by stimulating 14-3-3 binding and blocking Raf-1 interaction with Ras. J Biol Chem. 2003;278:29819-23 pubmed
    ..These studies suggest that Raf-1 and cAMP form a signaling complex in cells. Upon activation of PKA, Raf-1 is phosphorylated and 14-3-3 binds, blocking Raf-1 recruitment to the plasma membrane and preventing its activation. ..
  72. Al Arabi Y, Nader M, Nader M, Hamidian Jahromi A, Woods D. The effect of the timing of antibiotics and surgical treatment on infection rates in open long-bone fractures: a 9-year prospective study from a district general hospital. Injury. 2007;38:900-5 pubmed
    ..Whilst open long-bone fractures should be treated expeditiously, we suggest that adherence to a 6h window has not been shown to affect infection rates nor has the timing of antibiotic administration during the acute phase. ..
  73. Grimsey N, Han G, O Hara L, Rochford J, Carman G, Siniossoglou S. Temporal and spatial regulation of the phosphatidate phosphatases lipin 1 and 2. J Biol Chem. 2008;283:29166-74 pubmed publisher
    ..We propose that distinct and non-redundant functions of lipin 1 and 2 regulate lipid production during the cell cycle and adipocyte differentiation. ..
  74. Wildeboer D, Jiang P, Price R, Yu S, Jeganathan F, Abuknesha R. Use of antibody-hapten complexes attached to optical sensor surfaces as a substrate for proteases: real-time biosensing of protease activity. Talanta. 2010;81:68-75 pubmed publisher
  75. Mostofi A, Holtzman T, Grout A, Yeo C, Edgley S. Electrophysiological localization of eyeblink-related microzones in rabbit cerebellar cortex. J Neurosci. 2010;30:8920-34 pubmed publisher
    ..These small eyeblink-related areas provide cerebellar cortical targets for analysis of eyeblink conditioning at a neuronal level but need to be localized with electrophysiological identification in individual animals. ..
  76. Bhardwaj N, Dormer J, Ahmad F, Strickland A, Gravante G, Beckingham I, et al. Heat shock protein 70 expression following hepatic radiofrequency ablation is affected by adjacent vasculature. J Surg Res. 2012;173:249-57 pubmed publisher
    ..These findings suggest that heat shock proteins may play a role in the ability of damaged cells to recover and survive at the periphery of an ablation zone. ..
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