Genomes and Genes
Experts and Doctors on theilovirus in United States
Locale: United States
- Murray P, McGavern D, Sathornsumetee S, Rodriguez M. Spontaneous remyelination following extensive demyelination is associated with improved neurological function in a viral model of multiple sclerosis. Brain. 2001;124:1403-16 pubmed..Of greater importance, functional recovery occurred despite previous severe demyelination and spinal cord atrophy. ..
- Nelson A, Bieber A, Rodriguez M. Contrasting murine models of MS. Int MS J. 2004;11:95-9 pubmed..Analysing therapeutic successes and failures with both models may also help the development of more directed, positive treatments for MS that have fewer negative effects. ..
- Ransohoff R, Wei T, Pavelko K, Lee J, Murray P, Rodriguez M. Chemokine expression in the central nervous system of mice with a viral disease resembling multiple sclerosis: roles of CD4+ and CD8+ T cells and viral persistence. J Virol. 2002;76:2217-24 pubmed..Our observations indicated that chemokine expression in the CNS in this chronic viral disorder was intrinsic to the CNS innate immune response to infection and was not governed by elements of the adaptive immune system. ..
- Buenz E, Rodriguez M, Howe C. Disrupted spatial memory is a consequence of picornavirus infection. Neurobiol Dis. 2006;24:266-73 pubmed..An important implication of such subclinical virus-induced neurologic deficit is that the injury may accumulate over the lifetime of the individual, eventually leading to the manifestation of clinical cognitive or memory deficits...
- Murray P, McGavern D, Lin X, Njenga M, Leibowitz J, Pease L, et al. Perforin-dependent neurologic injury in a viral model of multiple sclerosis. J Neurosci. 1998;18:7306-14 pubmed..These studies implicate perforin release by CD8(+) T cells as a potential mechanism by which neurologic deficits are induced after demyelination. ..
- Barker Haliski M, Loscher W, White H, Galanopoulou A. Neuroinflammation in epileptogenesis: Insights and translational perspectives from new models of epilepsy. Epilepsia. 2017;58 Suppl 3:39-47 pubmed publisher..Utilization of these models may facilitate the identification of age-specific, syndrome- or etiology-specific therapies for the epilepsies and attendant comorbidities, including the drug-resistant forms. ..
- Young E, Sieve A, Vichaya E, Carcoba L, Young C, Ambrus A, et al. Chronic restraint stress during early Theiler's virus infection exacerbates the subsequent demyelinating disease in SJL mice: II. CNS disease severity. J Neuroimmunol. 2010;220:79-89 pubmed publisher..These findings indicate that RS during early TMEV infection increases CNS lesion formation during the late phase and suggest that the effects of RS are sex-dependent...
- Deb C, Lafrance Corey R, Zoecklein L, Papke L, Rodriguez M, Howe C. Demyelinated axons and motor function are protected by genetic deletion of perforin in a mouse model of multiple sclerosis. J Neuropathol Exp Neurol. 2009;68:1037-48 pubmed publisher..These results suggest that perforin is a key mediator of axon injury and lend additional support to the hypothesis that CD8 T cells are primarily responsible for axon damage in multiple sclerosis. ..
- Hudson C, Christophi G, Gruber R, Wilmore J, Lawrence D, Massa P. Induction of IL-33 expression and activity in central nervous system glia. J Leukoc Biol. 2008;84:631-43 pubmed publisher..In conclusion, these results implicate IL-33-producing astrocytes as a potentially critical regulator of innate immune responses in the CNS. ..
- Rodriguez M, Zoecklein L, Gamez J, Pavelko K, Papke L, Nakane S, et al. STAT4- and STAT6-signaling molecules in a murine model of multiple sclerosis. FASEB J. 2006;20:343-5 pubmed..Thus, virus infection of STAT4-/- mice results in a model that may allow for dissection of the immune events predisposing to late-onset demyelination in MS. ..
- Bieber A, Ure D, Rodriguez M. Genetically dominant spinal cord repair in a murine model of chronic progressive multiple sclerosis. J Neuropathol Exp Neurol. 2005;64:46-57 pubmed..These results highlight the significant extent to which hereditary factors can control disease course and demonstrate that the switch from a pathogenic to a reparative phenotype can occur even after prolonged inflammatory demyelination...
- Rodriguez M, Zoecklein L, Howe C, Pavelko K, Gamez J, Nakane S, et al. Gamma interferon is critical for neuronal viral clearance and protection in a susceptible mouse strain following early intracranial Theiler's murine encephalomyelitis virus infection. J Virol. 2003;77:12252-65 pubmed..These data support the hypothesis that IFN-gamma plays a critical role in protecting spinal cord neurons from persistent infection and death...
- Pavelko K, Howe C, Drescher K, Gamez J, Johnson A, Wei T, et al. Interleukin-6 protects anterior horn neurons from lethal virus-induced injury. J Neurosci. 2003;23:481-92 pubmed..These data support the hypothesis that IL-6 plays a critical role in protecting specific populations of neurons from irreversible injury. ..
- Massa P, Ropka S, Saha S, Fecenko K, Beuler K. Critical role for protein tyrosine phosphatase SHP-1 in controlling infection of central nervous system glia and demyelination by Theiler's murine encephalomyelitis virus. J Virol. 2002;76:8335-46 pubmed..These findings indicate that SHP-1 is a critical factor in controlling virus replication in the CNS glia and virus-induced demyelination. ..