Experts and Doctors on theilovirus in United States


Locale: United States
Topic: theilovirus

Top Publications

  1. Ure D, Rodriguez M. Polyreactive antibodies to glatiramer acetate promote myelin repair in murine model of demyelinating disease. FASEB J. 2002;16:1260-2 pubmed
    ..Thus, several mechanisms may have contributed to the promotion of remyelination. These results support the hypothesis that the antibody response in GA-treated patients is beneficial by facilitating repair of demyelinated lesions. ..
  2. Howe C, Lafrance Corey R, Sundsbak R, Sauer B, Lafrance S, Buenz E, et al. Hippocampal protection in mice with an attenuated inflammatory monocyte response to acute CNS picornavirus infection. Sci Rep. 2012;2:545 pubmed publisher
    ..These findings show that inflammatory monocytes are the critical cellular mediator of hippocampal injury during acute picornavirus infection of the brain. ..
  3. Gilli F, Li L, Pachner A. The immune response in the CNS in Theiler's virus induced demyelinating disease switches from an early adaptive response to a chronic innate-like response. J Neurovirol. 2016;22:66-79 pubmed publisher
    ..CSF provides an optimal source of biomarkers of CNS neuroinflammation. ..
  4. Nastasijevic B, Wright B, Smestad J, Warrington A, Rodriguez M, Maher L. Remyelination induced by a DNA aptamer in a mouse model of multiple sclerosis. PLoS ONE. 2012;7:e39595 pubmed publisher
    ..Relative to monoclonal antibodies, DNA aptamers are small, stable, and non-immunogenic, suggesting new possibilities for MS treatment. ..
  5. Pachner A, Brady J, Narayan K. Antibody-secreting cells in the central nervous system in an animal model of MS: Phenotype, association with disability, and in vitro production of antibody. J Neuroimmunol. 2007;190:112-20 pubmed
    ..Our data raise the possibility that ITAbP contributes significantly to disability, both in this model and in MS. ..
  6. Pavelko K, Bell M, Karyampudi L, Hansen M, Allen K, Knutson K, et al. The epitope integration site for vaccine antigens determines virus control while maintaining efficacy in an engineered cancer vaccine. Mol Ther. 2013;21:1087-95 pubmed publisher
  7. Olson J. Immune response by microglia in the spinal cord. Ann N Y Acad Sci. 2010;1198:271-8 pubmed publisher
    ..These studies suggest that microglia in the spinal cord may have different immune reactivity than microglia in the brain, which may contribute to spinal cord diseases. ..
  8. Vichaya E, Young E, Frazier M, Cook J, Welsh C, Meagher M. Social disruption induced priming of CNS inflammatory response to Theiler's virus is dependent upon stress induced IL-6 release. J Neuroimmunol. 2011;239:44-52 pubmed publisher
    ..Furthermore, this study demonstrated SDR prior to infection increases infection related central IL-6 and IL-1? mRNA expression, and administration of IL-6 neutralizing antibody during SDR reverses this increase in neuroinflammation. ..
  9. Ciomperlik J, Basta H, Palmenberg A. Cardiovirus Leader proteins bind exportins: Implications for virus replication and nucleocytoplasmic trafficking inhibition. Virology. 2016;487:19-26 pubmed publisher
    ..The involvement of exportins in this mechanism is important to viral replication and the observation of trafficking inhibition by LE. ..

More Information


  1. Murray P, McGavern D, Sathornsumetee S, Rodriguez M. Spontaneous remyelination following extensive demyelination is associated with improved neurological function in a viral model of multiple sclerosis. Brain. 2001;124:1403-16 pubmed
    ..Of greater importance, functional recovery occurred despite previous severe demyelination and spinal cord atrophy. ..
  2. Nelson A, Bieber A, Rodriguez M. Contrasting murine models of MS. Int MS J. 2004;11:95-9 pubmed
    ..Analysing therapeutic successes and failures with both models may also help the development of more directed, positive treatments for MS that have fewer negative effects. ..
  3. Christophi G, Hudson C, Gruber R, Christophi C, Massa P. Promoter-specific induction of the phosphatase SHP-1 by viral infection and cytokines in CNS glia. J Neurochem. 2008;105:2511-23 pubmed publisher
  4. Ransohoff R, Wei T, Pavelko K, Lee J, Murray P, Rodriguez M. Chemokine expression in the central nervous system of mice with a viral disease resembling multiple sclerosis: roles of CD4+ and CD8+ T cells and viral persistence. J Virol. 2002;76:2217-24 pubmed
    ..Our observations indicated that chemokine expression in the CNS in this chronic viral disorder was intrinsic to the CNS innate immune response to infection and was not governed by elements of the adaptive immune system. ..
  5. Buenz E, Rodriguez M, Howe C. Disrupted spatial memory is a consequence of picornavirus infection. Neurobiol Dis. 2006;24:266-73 pubmed
    ..An important implication of such subclinical virus-induced neurologic deficit is that the injury may accumulate over the lifetime of the individual, eventually leading to the manifestation of clinical cognitive or memory deficits...
  6. Christophi G, Hudson C, Panos M, Gruber R, Massa P. Modulation of macrophage infiltration and inflammatory activity by the phosphatase SHP-1 in virus-induced demyelinating disease. J Virol. 2009;83:522-39 pubmed publisher
  7. Murray P, McGavern D, Lin X, Njenga M, Leibowitz J, Pease L, et al. Perforin-dependent neurologic injury in a viral model of multiple sclerosis. J Neurosci. 1998;18:7306-14 pubmed
    ..These studies implicate perforin release by CD8(+) T cells as a potential mechanism by which neurologic deficits are induced after demyelination. ..
  8. Barker Haliski M, Loscher W, White H, Galanopoulou A. Neuroinflammation in epileptogenesis: Insights and translational perspectives from new models of epilepsy. Epilepsia. 2017;58 Suppl 3:39-47 pubmed publisher
    ..Utilization of these models may facilitate the identification of age-specific, syndrome- or etiology-specific therapies for the epilepsies and attendant comorbidities, including the drug-resistant forms. ..
  9. Young E, Sieve A, Vichaya E, Carcoba L, Young C, Ambrus A, et al. Chronic restraint stress during early Theiler's virus infection exacerbates the subsequent demyelinating disease in SJL mice: II. CNS disease severity. J Neuroimmunol. 2010;220:79-89 pubmed publisher
    ..These findings indicate that RS during early TMEV infection increases CNS lesion formation during the late phase and suggest that the effects of RS are sex-dependent...
  10. Christophi G, Massa P. Central neuroinvasion and demyelination by inflammatory macrophages after peripheral virus infection is controlled by SHP-1. Viral Immunol. 2009;22:371-87 pubmed publisher
  11. Deb C, Lafrance Corey R, Zoecklein L, Papke L, Rodriguez M, Howe C. Demyelinated axons and motor function are protected by genetic deletion of perforin in a mouse model of multiple sclerosis. J Neuropathol Exp Neurol. 2009;68:1037-48 pubmed publisher
    ..These results suggest that perforin is a key mediator of axon injury and lend additional support to the hypothesis that CD8 T cells are primarily responsible for axon damage in multiple sclerosis. ..
  12. Hudson C, Christophi G, Gruber R, Wilmore J, Lawrence D, Massa P. Induction of IL-33 expression and activity in central nervous system glia. J Leukoc Biol. 2008;84:631-43 pubmed publisher
    ..In conclusion, these results implicate IL-33-producing astrocytes as a potentially critical regulator of innate immune responses in the CNS. ..
  13. Rodriguez M, Zoecklein L, Gamez J, Pavelko K, Papke L, Nakane S, et al. STAT4- and STAT6-signaling molecules in a murine model of multiple sclerosis. FASEB J. 2006;20:343-5 pubmed
    ..Thus, virus infection of STAT4-/- mice results in a model that may allow for dissection of the immune events predisposing to late-onset demyelination in MS. ..
  14. Bieber A, Ure D, Rodriguez M. Genetically dominant spinal cord repair in a murine model of chronic progressive multiple sclerosis. J Neuropathol Exp Neurol. 2005;64:46-57 pubmed
    ..These results highlight the significant extent to which hereditary factors can control disease course and demonstrate that the switch from a pathogenic to a reparative phenotype can occur even after prolonged inflammatory demyelination...
  15. Rodriguez M, Zoecklein L, Howe C, Pavelko K, Gamez J, Nakane S, et al. Gamma interferon is critical for neuronal viral clearance and protection in a susceptible mouse strain following early intracranial Theiler's murine encephalomyelitis virus infection. J Virol. 2003;77:12252-65 pubmed
    ..These data support the hypothesis that IFN-gamma plays a critical role in protecting spinal cord neurons from persistent infection and death...
  16. Pavelko K, Howe C, Drescher K, Gamez J, Johnson A, Wei T, et al. Interleukin-6 protects anterior horn neurons from lethal virus-induced injury. J Neurosci. 2003;23:481-92 pubmed
    ..These data support the hypothesis that IL-6 plays a critical role in protecting specific populations of neurons from irreversible injury. ..
  17. Massa P, Ropka S, Saha S, Fecenko K, Beuler K. Critical role for protein tyrosine phosphatase SHP-1 in controlling infection of central nervous system glia and demyelination by Theiler's murine encephalomyelitis virus. J Virol. 2002;76:8335-46 pubmed
    ..These findings indicate that SHP-1 is a critical factor in controlling virus replication in the CNS glia and virus-induced demyelination. ..