Experts and Doctors on testis in Canada


Locale: Canada
Topic: testis

Top Publications

  1. Wang H, Betti M. Sulfated glycosaminoglycan-derived oligosaccharides produced from chicken connective tissue promote iron uptake in a human intestinal Caco-2 cell line. Food Chem. 2017;220:460-469 pubmed publisher
    ..The enhanced iron uptake through enzymatic GAG depolymerisation could be due to the combined effects of reduced molecular weight, increased amount of hydroxyl terminal groups and ferric reducing activities. ..
  2. Memari N, Grass L, Nakamura T, Karakucuk I, Diamandis E. Human tissue kallikrein 9: production of recombinant proteins and specific antibodies. Biol Chem. 2006;387:733-40 pubmed
    ..hK9 was mainly detected in testis and seminal vesicles by Western blotting. The reagents generated here will help to define the physiological role of this tissue kallikrein and its involvement in human disease. ..
  3. Campbell S, Wiebe J. Stimulation of spermatocyte development in prepubertal rats by the Sertoli cell steroid, 3 alpha-hydroxy-4-pregnen-20-one. Biol Reprod. 1989;40:897-905 pubmed
    ..It does not appear that this effect is mediated through the conversion of 3HP to any C21 or C19 steroids, and appears to be the first report of a Sertoli cell steroid with a possible role in the process of mammalian spermatogenesis. ..
  4. Lachance C, Fortier M, Thimon V, Sullivan R, Bailey J, Leclerc P. Localization of Hsp60 and Grp78 in the human testis, epididymis and mature spermatozoa. Int J Androl. 2010;33:33-44 pubmed publisher
    ..These findings are in agreement with the involvement of Hsp60 and Grp78 during spermatogenesis and in sperm functions such as fertilization. ..
  5. Dores C, Alpaugh W, Dobrinski I. From in vitro culture to in vivo models to study testis development and spermatogenesis. Cell Tissue Res. 2012;349:691-702 pubmed publisher
  6. Boyer A, Paquet M, Laguë M, Hermo L, Boerboom D. Dysregulation of WNT/CTNNB1 and PI3K/AKT signaling in testicular stromal cells causes granulosa cell tumor of the testis. Carcinogenesis. 2009;30:869-78 pubmed publisher
    ..Together, these data provide the first insights into the molecular etiology of GCTT and the first animal model for the study of GCTT biology...
  7. Lupien M, Dievart A, Morales C, Hermo L, Calvo E, Kay D, et al. Expression of constitutively active Notch1 in male genital tracts results in ectopic growth and blockage of efferent ducts, epididymal hyperplasia and sterility. Dev Biol. 2006;300:497-511 pubmed
    ..This phenotype seems to represent a novel developmental defect in mammals. Together, these results show that constitutive Notch1 signaling significantly affects the development of male reproductive organs. ..
  8. Wellington C, Walker E, Suarez A, Kwok A, Bissada N, Singaraja R, et al. ABCA1 mRNA and protein distribution patterns predict multiple different roles and levels of regulation. Lab Invest. 2002;82:273-83 pubmed
    ..Our observations show that ABCA1 is expressed in a pattern consistent with its role in HDL-C metabolism. Additionally, ABCA1 may have important functional roles in other cell types independent of HDL-C regulation...
  9. Garber A, Winkfein R, Dixon G. A novel creatine kinase cDNA whose transcript shows enhanced testicular expression. Biochim Biophys Acta. 1990;1087:256-8 pubmed
    ..Northern blot analyses demonstrated preferential expression of this CK subunit in testis relative to other CK containing organs. Southern blot analysis suggested a single copy number for this CK gene...

More Information


  1. Ruan Y, Cheng M, Ou Y, Oko R, van der Hoorn F. Ornithine decarboxylase antizyme Oaz3 modulates protein phosphatase activity. J Biol Chem. 2011;286:29417-27 pubmed publisher
    ..This is, to our knowledge, the first demonstration of a novel activity for an Oaz-encoded protein. ..
  2. Gyamera Acheampong C, Mbikay M. Proprotein convertase subtilisin/kexin type 4 in mammalian fertility: a review. Hum Reprod Update. 2009;15:237-47 pubmed publisher
    ..Alterations of PCSK4 expression or activity could be the underlying cause of some unexplained cases of human infertility. Conversely, inactivation of this protease represents a potential strategy for non-hormonal contraception. ..
  3. Al Katib W, Dennis S. Pathological changes in accessory sex organs of rams following experimental infection with Actinobacillus seminis. N Z Vet J. 2008;56:319-25 pubmed publisher
    ..To investigate and assess the susceptibility, lesions and route of dissemination in the accessory sex organs of young rams experimentally infected with Actinobacillus seminis...
  4. Cui S, Ross A, Stallings N, Parker K, Capel B, Quaggin S. Disrupted gonadogenesis and male-to-female sex reversal in Pod1 knockout mice. Development. 2004;131:4095-105 pubmed
    ..Our results establish that Pod1 is essential for gonadal development, and place it in a transcriptional network that orchestrates cell fate decisions in gonadal progenitors. ..
  5. Duguay Y, Lapointe A, Lavallee B, Hum D, Rivest S. Cloning of murine TReP-132, a novel transcription factor expressed in brain regions involved in behavioral and psychiatric disorders. Mol Psychiatry. 2003;8:39-49 pubmed
    ..The molecular cloning and the highly specific expression of mTReP-132 across the brain further consolidate the hypothesis that this tissue is able to synthesize de novo steroids in a region-specific manner. ..
  6. Fleury A, Cloutier M, Ducharme L, Lefebvre A, Lehoux J, LeHoux J. Adrenocorticotropin regulates the level of the steroidogenic acute regulatory (StAR) protein mRNA in hamster adrenals. Endocr Res. 1996;22:515-20 pubmed
  7. Trudeau V, Matzuk M, Hache R, Renaud L. Overexpression of activin-beta A subunit mRNA is associated with decreased activin type II receptor mRNA levels in the testes of alpha-inhibin deficient mice. Biochem Biophys Res Commun. 1994;203:105-12 pubmed
    ..These results demonstrate that increased expression of activin is accompanied by a tissue specific reduction in the expression of its own receptor mRNA in vivo. ..
  8. Chin M, Li G. Tissue-specific regulation of checkpoint kinase 2 expression by p53. Exp Mol Pathol. 2003;75:131-6 pubmed
    ..Similar Chk2 expression was observed in the brain, skin, spleen, and testis in p53(+/+) and p53(-/-) mice. These data indicate that p53 regulates Chk2 expression in a tissue-specific manner. ..
  9. Modarressi M, Behnam B, Cheng M, Taylor K, Wolfe J, van der Hoorn F. Tsga10 encodes a 65-kilodalton protein that is processed to the 27-kilodalton fibrous sheath protein. Biol Reprod. 2004;70:608-15 pubmed
    ..Our results suggest the possibility that Tsga10 plays a role in the sperm tail fibrous sheath. ..
  10. Boyer A, Lussier J, Sinclair A, McClive P, Silversides D. Pre-sertoli specific gene expression profiling reveals differential expression of Ppt1 and Brd3 genes within the mouse genital ridge at the time of sex determination. Biol Reprod. 2004;71:820-7 pubmed
    ..We conclude that combining transgenically marked fluorescent cell populations with differential expression screening is useful for cell expression profiling in developmental systems such as sex determination and differentiation. ..
  11. Gizard F, Lavallee B, Dewitte F, Hum D. A novel zinc finger protein TReP-132 interacts with CBP/p300 to regulate human CYP11A1 gene expression. J Biol Chem. 2001;276:33881-92 pubmed
    ..Thus, these results together indicate the isolation of a novel zinc-finger transcriptional regulating protein of 132 kDa (TReP-132) involved in the regulation of P450scc gene expression. ..
  12. Frenette G, Sullivan R. Prostasome-like particles are involved in the transfer of P25b from the bovine epididymal fluid to the sperm surface. Mol Reprod Dev. 2001;59:115-21 pubmed
    ..P25b thus appears to be a marker of sperm epididymal maturation in bulls. ..
  13. Dufort I, Labrie F, Luu The V. Human types 1 and 3 3 alpha-hydroxysteroid dehydrogenases: differential lability and tissue distribution. J Clin Endocrinol Metab. 2001;86:841-6 pubmed
  14. Pacey L, Doss L, Cifelli C, van der Kooy D, Heximer S, Hampson D. Genetic deletion of regulator of G-protein signaling 4 (RGS4) rescues a subset of fragile X related phenotypes in the FMR1 knockout mouse. Mol Cell Neurosci. 2011;46:563-72 pubmed publisher
    ..These findings suggest that tissue and cell-type specific differences in GPCR signaling and RGS function may contribute to the spectrum of phenotypic differences observed in FXS. ..
  15. Stros M, Nishikawa S, Dixon G. cDNA sequence and structure of a gene encoding trout testis high-mobility-group-1 protein. Eur J Biochem. 1994;225:581-91 pubmed
    ..amp; Yoshida, M. (1992). J. Biol. Chem. 267, 6641-6645] suggesting the evolution of HMG-1 and HMG-2 genes from a common ancestor. ..
  16. Boer P, Adra C, Lau Y, McBurney M. The testis-specific phosphoglycerate kinase gene pgk-2 is a recruited retroposon. Mol Cell Biol. 1987;7:3107-12 pubmed
    ..The pgk-2 gene may, then, be a transcribed retroposon. Thus, gene duplication by retroposition may have been used as a mechanism for evolutionary diversification. ..
  17. Chen Q, Pearlman R, Moens P. Isolation and characterization of a cDNA encoding a synaptonemal complex protein. Biochem Cell Biol. 1992;70:1030-8 pubmed
    ..The protein shows no overall similarity to proteins of known function, nor is there similarity to protein sequences present in GenBank or EMBL data bases. ..
  18. Carpentier M, Guillemette C, Bailey J, Boileau G, Jeannotte L, DesGroseillers L, et al. Reduced fertility in male mice deficient in the zinc metallopeptidase NL1. Mol Cell Biol. 2004;24:4428-37 pubmed
    ..Basic sperm parameters were also normal. Thus, our findings suggest that one of the roles of NL1 in mice is related to sperm function and that NL1 modulates the processes of fertilization and early embryonic development in vivo. ..
  19. Durocher F, Sanchez R, Ricketts M, Labrie Y, Laudet V, Simard J. Characterization of the guinea pig 3beta-hydroxysteroid dehydrogenase/Delta5-Delta4-isomerase expressed in the adrenal gland and gonads. J Steroid Biochem Mol Biol. 2005;97:289-98 pubmed
  20. McBurney M, Yang X, Jardine K, Hixon M, Boekelheide K, Webb J, et al. The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis. Mol Cell Biol. 2003;23:38-54 pubmed
    ..The phenotype of the sir2alpha null animals suggests that the SIR2alpha protein is essential for normal embryogenesis and for normal reproduction in both sexes. ..