Genomes and Genes
Experts and Doctors on tertiary protein structure in United Kingdom
Locale: United Kingdom
Topic: tertiary protein structure
Publications251 found, 100 shown here
- Jørgensen H, Ben Porath I, Bird A. Mbd1 is recruited to both methylated and nonmethylated CpGs via distinct DNA binding domains. Mol Cell Biol. 2004;24:3387-95 pubmed..Our findings indicate that MBD1 can interpret the CpG dinucleotide as a repressive signal in vivo regardless of its methylation status. ..
- Toogood H, van Thiel A, Basran J, Sutcliffe M, Scrutton N, Leys D. Extensive domain motion and electron transfer in the human electron transferring flavoprotein.medium chain Acyl-CoA dehydrogenase complex. J Biol Chem. 2004;279:32904-12 pubmed
- Gabrielsen M, Bond C, Hallyburton I, Hecht S, Bacher A, Eisenreich W, et al. Hexameric assembly of the bifunctional methylerythritol 2,4-cyclodiphosphate synthase and protein-protein associations in the deoxy-xylulose-dependent pathway of isoprenoid precursor biosynthesis. J Biol Chem. 2004;279:52753-61 pubmed publisher..We propose that complex formation of the three enzymes at the core of the DOXP pathway can produce an assembly localizing 18 catalytic centers for the early stages of isoprenoid biosynthesis...
- Vickers E, Kasza A, Kurnaz I, Seifert A, Zeef L, O Donnell A, et al. Ternary complex factor-serum response factor complex-regulated gene activity is required for cellular proliferation and inhibition of apoptotic cell death. Mol Cell Biol. 2004;24:10340-51 pubmed..Thus, our data confirm a role for TCF-SRF-regulated gene activity in regulating proliferation and provide further evidence to indicate a role in protecting cells from apoptotic cell death. ..
- Wilson C, Kraft C, Duggan C, Ismail N, Crawshaw S, High S. Ribophorin I associates with a subset of membrane proteins after their integration at the sec61 translocon. J Biol Chem. 2005;280:4195-206 pubmed..Alternatively ribophorin I may be multifunctional and facilitate additional processes, for example, ER quality control. ..
- Tilley S, Orlova E, Gilbert R, Andrew P, Saibil H. Structural basis of pore formation by the bacterial toxin pneumolysin. Cell. 2005;121:247-56 pubmed..With an oligomer size of up to 44 subunits in the pore, this assembly creates a transmembrane channel 260 A in diameter lined by 176 beta strands. ..
- Michaux G, Abbitt K, Collinson L, Haberichter S, Norman K, Cutler D. The physiological function of von Willebrand's factor depends on its tubular storage in endothelial Weibel-Palade bodies. Dev Cell. 2006;10:223-32 pubmed..Thus, a 100-fold compaction of VWF into tubules determines the unique shape of Weibel-Palade bodies and is critical to this protein's hemostatic function...
- Liu D, Bischerour J, Siddique A, Buisine N, Bigot Y, Chalmers R. The human SETMAR protein preserves most of the activities of the ancestral Hsmar1 transposase. Mol Cell Biol. 2007;27:1125-32 pubmed
- Wang T, Holt C, Xu C, Ridley C, P O Jones R, Baron M, et al. Notch3 activation modulates cell growth behaviour and cross-talk to Wnt/TCF signalling pathway. Cell Signal. 2007;19:2458-67 pubmed
- Wolthers K, Lou X, Toogood H, Leys D, Scrutton N. Mechanism of coenzyme binding to human methionine synthase reductase revealed through the crystal structure of the FNR-like module and isothermal titration calorimetry. Biochemistry. 2007;46:11833-44 pubmed..The biological implications of an attenuated mechanism of MS reactivation by MSR on methionine and folate metabolism are discussed. ..
- Boter M, Amigues B, Peart J, Breuer C, Kadota Y, Casais C, et al. Structural and functional analysis of SGT1 reveals that its interaction with HSP90 is required for the accumulation of Rx, an R protein involved in plant immunity. Plant Cell. 2007;19:3791-804 pubmed..Biochemical reconstitution experiments suggest that RAR1 may function to enhance the SGT1-HSP90 interaction by promoting ternary complex formation. ..
- Butala M, Zgur Bertok D, Busby S. The bacterial LexA transcriptional repressor. Cell Mol Life Sci. 2009;66:82-93 pubmed publisher..These may provide new starting points in the battle against the emergence of bacterial pathogens and the spread of drug resistance among them. ..
- Yue W, Hozjan V, Ge W, Loenarz C, Cooper C, Schofield C, et al. Crystal structure of the PHF8 Jumonji domain, an Nepsilon-methyl lysine demethylase. FEBS Lett. 2010;584:825-30 pubmed publisher..The results rationalize the lack of activity for the clinically observed F279S PHF8 variant and they will help to identify inhibitors selective for specific N(epsilon)-methyl lysine demethylase subfamilies. ..
- Hughes E, Edwards R, Middleton D. Heparin-derived oligosaccharides interact with the phospholamban cytoplasmic domain and stimulate SERCA function. Biochem Biophys Res Commun. 2010;401:370-5 pubmed publisher..These results indicate that the cytoplasmic domain of PLB is functionally important and could be a valid target for compounds with drug-like properties. ..
- Lau K, McLoughlin D, Standen C, Miller C. X11 alpha and x11 beta interact with presenilin-1 via their PDZ domains. Mol Cell Neurosci. 2000;16:557-65 pubmed..These results suggest that the X11 regulation of APP processing is controlled, at least in part, via their interactions with APP and presenilin-1. ..
- Ardley H, Tan N, Rose S, Markham A, Robinson P. Features of the parkin/ariadne-like ubiquitin ligase, HHARI, that regulate its interaction with the ubiquitin-conjugating enzyme, Ubch7. J Biol Chem. 2001;276:19640-7 pubmed..These studies demonstrate that very subtle changes to the domains that regulate recognition between highly conserved components of the ubiquitin pathway can dramatically affect their ability to interact. ..
- Edgar A, Polak J. Cloning and tissue distribution of three murine alpha/beta hydrolase fold protein cDNAs. Biochem Biophys Res Commun. 2002;292:617-25 pubmed..mRNA expression levels of LABH1 and 3 were highest in liver and LABH2 highest in testis. These findings suggest that the LABH proteins consist of a novel family of membrane bound enzymes whose function has yet to be determined. ..
- Bouyain S, Silk N, Fabini G, Drickamer K. An endogenous Drosophila receptor for glycans bearing alpha 1,3-linked core fucose residues. J Biol Chem. 2002;277:22566-72 pubmed..CG2958 is a potential endogenous receptor for such neural-specific carbohydrate epitopes. ..
- Knupp C, Chong N, Munro P, Luthert P, Squire J. Analysis of the collagen VI assemblies associated with Sorsby's fundus dystrophy. J Struct Biol. 2002;137:31-40 pubmed..Understanding the structure of these collagen VI/TIMP assemblies in Bruch's membrane may prove to be important for understanding the pathophysiology of age-related macular degeneration. ..
- Glynne P, Darling K, Picot J, Evans T. Epithelial inducible nitric-oxide synthase is an apical EBP50-binding protein that directs vectorial nitric oxide output. J Biol Chem. 2002;277:33132-8 pubmed..These studies define human epithelial iNOS as an apical EBP50-binding protein and suggest that the physical association of iNOS with EBP50 might allow precise NO modulation of EBP50-associated protein functions. ..
- Le Jeune I, Shepherd M, Van Heeke G, Houslay M, Hall I. Cyclic AMP-dependent transcriptional up-regulation of phosphodiesterase 4D5 in human airway smooth muscle cells. Identification and characterization of a novel PDE4D5 promoter. J Biol Chem. 2002;277:35980-9 pubmed..We present evidence for cAMP-driven PDE4D5 up-regulation in hASMs and suggest a CRE-containing, isoform-specific promoter as the primary mechanism. ..
- Nesbit M, Bowl M, Harding B, Ali A, Ayala A, Crowe C, et al. Characterization of GATA3 mutations in the hypoparathyroidism, deafness, and renal dysplasia (HDR) syndrome. J Biol Chem. 2004;279:22624-34 pubmed
- Cordell P, Futers T, Grant P, Pease R. The Human hydroxyacylglutathione hydrolase (HAGH) gene encodes both cytosolic and mitochondrial forms of glyoxalase II. J Biol Chem. 2004;279:28653-61 pubmed..Analysis of glyoxalase II mRNA sequences from a number of species indicates that dual initiation from alternative AUG codons is conserved throughout vertebrates. ..
- Sayers I, Housden J, Spivey A, Helm B. The importance of Lys-352 of human immunoglobulin E in FcepsilonRII/CD23 recognition. J Biol Chem. 2004;279:35320-5 pubmed..Our results yield new insights into the structural basis of the hIgE-CD23 interaction and hold promise for the rational design of drugs that can manipulate IgE-mediated regulation of the allergic response. ..
- Harvey K, Duguid I, Alldred M, Beatty S, Ward H, Keep N, et al. The GDP-GTP exchange factor collybistin: an essential determinant of neuronal gephyrin clustering. J Neurosci. 2004;24:5816-26 pubmed..The clinical manifestation of this collybistin missense mutation may result, at least in part, from mislocalization of gephyrin and a major GABA(A) receptor subtype. ..
- Campbell J, Deol S, Ashcroft F, Kerr I, Sansom M. Nucleotide-dependent conformational changes in HisP: molecular dynamics simulations of an ABC transporter nucleotide-binding domain. Biophys J. 2004;87:3703-15 pubmed..These results support the mechanism for ATP-induced conformational transitions derived from the crystal structures of other NBDs. ..
- Wigneshweraraj S, Burrows P, Bordes P, Schumacher J, Rappas M, Finn R, et al. The second paradigm for activation of transcription. Prog Nucleic Acid Res Mol Biol. 2005;79:339-69 pubmed
- Seyfried J, Wang X, Kharebava G, Tournier C. A novel mitogen-activated protein kinase docking site in the N terminus of MEK5alpha organizes the components of the extracellular signal-regulated kinase 5 signaling pathway. Mol Cell Biol. 2005;25:9820-8 pubmed..Altogether these results establish that the N terminus of MEK5alpha is critical for the specific organization of the components of the ERK5 signaling pathway. ..
- Rickman C, Jimenez J, Graham M, Archer D, Soloviev M, Burgoyne R, et al. Conserved prefusion protein assembly in regulated exocytosis. Mol Biol Cell. 2006;17:283-94 pubmed
- Jenkinson E, Chong J. Minichromosome maintenance helicase activity is controlled by N- and C-terminal motifs and requires the ATPase domain helix-2 insert. Proc Natl Acad Sci U S A. 2006;103:7613-8 pubmed..Deletion of the helix-2 insert additionally resulted in the abrogation of DNA unwinding. Our results provide significant insight into the molecular mechanisms used by the MCM helicase to both regulate and execute DNA unwinding...
- ElAntak L, Tzakos A, Locker N, Lukavsky P. Structure of eIF3b RNA recognition motif and its interaction with eIF3j: structural insights into the recruitment of eIF3b to the 40 S ribosomal subunit. J Biol Chem. 2007;282:8165-74 pubmed..Our results provide the first structure of an important subdomain of a core eIF3 subunit and detailed insights into protein-protein interactions between two eIF3 subunits required for stable eIF3 recruitment to the 40 S subunit. ..
- Walker D, Mosbahi K, Vankemmelbeke M, James R, Kleanthous C. The role of electrostatics in colicin nuclease domain translocation into bacterial cells. J Biol Chem. 2007;282:31389-97 pubmed
- Calcagno Pizarelli A, Negrete Urtasun S, Denison S, Rudnicka J, Bussink H, Múnera Huertas T, et al. Establishment of the ambient pH signaling complex in Aspergillus nidulans: PalI assists plasma membrane localization of PalH. Eukaryot Cell. 2007;6:2365-75 pubmed
- Fernius J, Hardwick K. Bub1 kinase targets Sgo1 to ensure efficient chromosome biorientation in budding yeast mitosis. PLoS Genet. 2007;3:e213 pubmed..We propose that Bub1 kinase and Sgo1p act together to ensure efficient biorientation of sister chromatids during mitosis. ..
- Copland M, Pellicano F, Richmond L, Allan E, Hamilton A, Lee F, et al. BMS-214662 potently induces apoptosis of chronic myeloid leukemia stem and progenitor cells and synergizes with tyrosine kinase inhibitors. Blood. 2008;111:2843-53 pubmed..This is the first report of an agent with activity in resistant and blast crisis CML that selectively kills CML stem/progenitor cells through apoptosis and offers potential for eradication of chronic phase CML. ..
- Wells M, Tidow H, Rutherford T, Markwick P, Jensen M, Mylonas E, et al. Structure of tumor suppressor p53 and its intrinsically disordered N-terminal transactivation domain. Proc Natl Acad Sci U S A. 2008;105:5762-7 pubmed publisher..The core domains enveloped the response element in the center of the molecule, with the Taz2-bound TADs projecting outward from the core. ..
- Fyfe P, Oza S, Fairlamb A, Hunter W. Leishmania trypanothione synthetase-amidase structure reveals a basis for regulation of conflicting synthetic and hydrolytic activities. J Biol Chem. 2008;283:17672-80 pubmed publisher..The potential inhibitory role of the C terminus provides a mechanism to control relative levels of the critical metabolites, trypanothione, glutathionylspermidine, and spermidine in Leishmania. ..
- Greaves J, Salaun C, Fukata Y, Fukata M, Chamberlain L. Palmitoylation and membrane interactions of the neuroprotective chaperone cysteine-string protein. J Biol Chem. 2008;283:25014-26 pubmed publisher..The coupling of CSP palmitoylation to Golgi membranes may thus be an important requirement for subsequent sorting. ..
- Innis C, Hyvonen M. Crystal structures of the heparan sulfate-binding domain of follistatin. Insights into ligand binding. J Biol Chem. 2003;278:39969-77 pubmed
- Bunney T, Harris R, Gandarillas N, Josephs M, Roe S, Sorli S, et al. Structural and mechanistic insights into ras association domains of phospholipase C epsilon. Mol Cell. 2006;21:495-507 pubmed..Studies of PLCepsilon regulation suggest that, in a cellular context, the RA2 domain, in a mode specific to PLCepsilon, has a role in membrane targeting with further regulatory impact on PLC activity. ..
- Alzuherri H, McGilvray R, Kilbey A, Bartholomew C. Conservation and expression of a novel alternatively spliced Evi1 exon. Gene. 2006;384:154-62 pubmed
- Dickinson R, Peterson B, Banks P, Simillis C, Martin J, Valenzuela C, et al. Competitive inhibition at the glycine site of the N-methyl-D-aspartate receptor by the anesthetics xenon and isoflurane: evidence from molecular modeling and electrophysiology. Anesthesiology. 2007;107:756-67 pubmed..However, the site of action of these agents on the NMDA receptor is unknown. The authors show that xenon and isoflurane compete for the binding of the coagonist glycine on the NMDA receptor NR1 subunit...
- Rowley P, Smith M. Role of the N-terminal domain of phiC31 integrase in attB-attP synapsis. J Bacteriol. 2008;190:6918-21 pubmed publisher..We show here that substitutions in amino acid V129 in the NTD can lead to defects in synapsis and DNA cleavage, indicating that the NTD also has an important role in synapsis...
- Gingras A, Ziegler W, Bobkov A, Joyce M, Fasci D, Himmel M, et al. Structural determinants of integrin binding to the talin rod. J Biol Chem. 2009;284:8866-76 pubmed publisher..Thermal unfolding experiments show that integrin binding induces conformational changes in the IBS2 module, which we speculate are linked to vinculin and membrane binding. ..
- Belandia B, Parker M. Functional interaction between the p160 coactivator proteins and the transcriptional enhancer factor family of transcription factors. J Biol Chem. 2000;275:30801-5 pubmed..These results suggest that the p160 proteins could be bona fide coactivators of the TEF family of transcription factors. ..
- Patchell V, Gallon C, Evans J, Gao Y, Perry S, Levine B. The regulatory effects of tropomyosin and troponin-I on the interaction of myosin loop regions with F-actin. J Biol Chem. 2005;280:14469-75 pubmed..We suggest that the role of tropomyosin is to facilitate the transmission of structural changes along the F-actin filament so that the monomers within a structural unit are able to interact with myosin. ..
- Pierrat O, Maxwell A. Evidence for the role of DNA strand passage in the mechanism of action of microcin B17 on DNA gyrase. Biochemistry. 2005;44:4204-15 pubmed..We suggest that the binding site of MccB17 is in the C-terminal domain of GyrB. ..
- Coyne K, Gaskell R, Dawson S, Porter C, Radford A. Evolutionary mechanisms of persistence and diversification of a calicivirus within endemically infected natural host populations. J Virol. 2007;81:1961-71 pubmed..Reiteration of both progressive evolution and variant reinfection appeared to lead to a gradual increase in the diversity of a given strain of virus, both in the individual and in the population, until eventually new strains emerged. ..
- Donnelly M, Verhagen J, Elliott G. RNA binding by the herpes simplex virus type 1 nucleocytoplasmic shuttling protein UL47 is mediated by an N-terminal arginine-rich domain that also functions as its nuclear localization signal. J Virol. 2007;81:2283-96 pubmed publisher..Using RNA immunoprecipitations, we demonstrate that hUL47 is also bound in vivo to at least one viral transcript, the ICP0 mRNA. Taken together, these results suggest that hUL47 may play a role in RNA biogenesis in the infected cell...
- Meenan N, Visai L, Valtulina V, Schwarz Linek U, Norris N, Gurusiddappa S, et al. The tandem beta-zipper model defines high affinity fibronectin-binding repeats within Staphylococcus aureus FnBPA. J Biol Chem. 2007;282:25893-902 pubmed..The in vivo relevance of the in vitro binding studies is confirmed by the presence of antibodies in patients with S. aureus infections that specifically recognize complexes of these six high affinity repeats with fibronectin. ..
- Stephens L, Anderson K, Hawkins P. Src family kinases mediate receptor-stimulated, phosphoinositide 3-kinase-dependent, tyrosine phosphorylation of dual adaptor for phosphotyrosine and 3-phosphoinositides-1 in endothelial and B cell lines. J Biol Chem. 2001;276:42767-73 pubmed..We conclude that Src family kinases are responsible for tyrosine phosphorylation of DAPP-1 in vivo and that PI3K regulation is at the level of PH domain-mediated translocation of DAPP-1 to PI3K products in the membrane. ..
- Faraldo Gómez J, Smith G, Sansom M. Molecular dynamics simulations of the bacterial outer membrane protein FhuA: a comparative study of the ferrichrome-free and bound states. Biophys J. 2003;85:1406-20 pubmed..These simulations are among the longest that have been performed on a complex membrane protein. However, a simple analysis of sampling reveals that the description of protein motions is far from complete...
- Cobbe N, Heck M. The evolution of SMC proteins: phylogenetic analysis and structural implications. Mol Biol Evol. 2004;21:332-47 pubmed..Finally, we propose a possible structure for the SMC5/SMC6 heterodimer based on patterns of coevolution...
- Frigerio G, Grimsey N, Dale M, Majoul I, Duden R. Two human ARFGAPs associated with COP-I-coated vesicles. Traffic. 2007;8:1644-55 pubmed..However, silencing all three ARFGAPs causes cell death. Our data provide strong evidence that ARFGAP2 and ARFGAP3 function in COP I traffic. ..
- Cao Z, Roszak A, Gourlay L, Lindsay J, Isaacs N. Bovine mitochondrial peroxiredoxin III forms a two-ring catenane. Structure. 2005;13:1661-4 pubmed..These two major modes of subunit interaction provide important insights into possible mechanisms of catenane formation. ..
- Allen M, Buchberger A, Bycroft M. The PUB domain functions as a p97 binding module in human peptide N-glycanase. J Biol Chem. 2006;281:25502-8 pubmed..Furthermore, we show that the PUB and UBX domains do not bind to p97 in a mutually exclusive manner. Our results suggest that PUB domain-containing proteins constitute a widespread family of diverse p97 cofactors. ..
- Bevan C, Hoare S, Claessens F, Heery D, Parker M. The AF1 and AF2 domains of the androgen receptor interact with distinct regions of SRC1. Mol Cell Biol. 1999;19:8383-92 pubmed..This recruitment is in direct contrast to the recruitment of SRC1 to the estrogen receptor, which requires interaction with the ligand-binding domain. ..
- Sarcina M, Tobin M, Mullineaux C. Diffusion of phycobilisomes on the thylakoid membranes of the cyanobacterium Synechococcus 7942. Effects of phycobilisome size, temperature, and membrane lipid composition. J Biol Chem. 2001;276:46830-4 pubmed..The results cannot be explained in terms of changes in the fluidity of the membrane; they suggest that lipids play a role in controlling phycobilisome-reaction center interaction...
- Hsieh J, Yap D, O Connor D, Fogal V, Fallis L, Chan F, et al. Novel function of the cyclin A binding site of E2F in regulating p53-induced apoptosis in response to DNA damage. Mol Cell Biol. 2002;22:78-93 pubmed..These results suggest that the binding of E2F1 to p53 can specifically stimulate the apoptotic function of p53 in response to DNA damage. ..
- Aricescu A, McKinnell I, Halfter W, Stoker A. Heparan sulfate proteoglycans are ligands for receptor protein tyrosine phosphatase sigma. Mol Cell Biol. 2002;22:1881-92 pubmed..HSPGs are therefore a novel class of heterotypic ligand for cPTPsigma, suggesting that cPTPsigma signaling in axons and growth cones is directly responsive to matrix-associated cues. ..
- Pittman M, Corker H, Wu G, Binet M, Moir A, Poole R. Cysteine is exported from the Escherichia coli cytoplasm by CydDC, an ATP-binding cassette-type transporter required for cytochrome assembly. J Biol Chem. 2002;277:49841-9 pubmed..We propose that CydDC exports cysteine, crucial for redox homeostasis in the periplasm...
- Huntington J, Li W. Structural insights into the multiple functions of protein C inhibitor. Cell Mol Life Sci. 2009;66:113-21 pubmed publisher..They reveal a conserved serpin fold and general mechanism of protease inhibition, but with some unique features relating to inhibitory specificity/promiscuity, cofactor binding and hydrophobic ligand transport. ..
- Swaminathan G, Holloway D, Colvin R, Campanella G, Papageorgiou A, Luster A, et al. Crystal structures of oligomeric forms of the IP-10/CXCL10 chemokine. Structure. 2003;11:521-32 pubmed..We propose that the tetrameric structures may represent species promoted by the binding of glycosaminoglycans. The binding sites for several IP-10-neutralizing mAbs have also been mapped. ..
- Dode L, Andersen J, Leslie N, Dhitavat J, Vilsen B, Hovnanian A. Dissection of the functional differences between sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) 1 and 2 isoforms and characterization of Darier disease (SERCA2) mutants by steady-state and transient kinetic analyses. J Biol Chem. 2003;278:47877-89 pubmed..In this case, the disease may be a consequence of the low expression level and/or reduction of Ca2+ affinity and sensitivity to inhibition by lumenal Ca2+. ..
- Penfold C, Healy B, Housden N, Boetzel R, Vankemmelbeke M, Moore G, et al. Flexibility in the receptor-binding domain of the enzymatic colicin E9 is required for toxicity against Escherichia coli cells. J Bacteriol. 2004;186:4520-7 pubmed..The data are consistent with a requirement for the flexibility of the coiled-coil R domain after binding to BtuB. ..
- Horsefield R, Yankovskaya V, Sexton G, Whittingham W, Shiomi K, Omura S, et al. Structural and computational analysis of the quinone-binding site of complex II (succinate-ubiquinone oxidoreductase): a mechanism of electron transfer and proton conduction during ubiquinone reduction. J Biol Chem. 2006;281:7309-16 pubmed..This allows us to propose a mechanism for the reduction of ubiquinone during the catalytic turnover of the enzyme. ..
- Cañadillas J, Tidow H, Freund S, Rutherford T, Ang H, Fersht A. Solution structure of p53 core domain: structural basis for its instability. Proc Natl Acad Sci U S A. 2006;103:2109-14 pubmed..p53 appears to have evolved to be dynamic and unstable. ..
- Egloff S, Al Rawaf H, O Reilly D, Murphy S. Chromatin structure is implicated in "late" elongation checkpoints on the U2 snRNA and beta-actin genes. Mol Cell Biol. 2009;29:4002-13 pubmed publisher..Furthermore, CTCF colocalizes with NELF on the U2 and beta-actin genes, raising the possibility that it helps the positioning and/or function of the NELF-dependent control point on these genes. ..
- Inforzato A, Baldock C, Jowitt T, Holmes D, Lindstedt R, Marcellini M, et al. The angiogenic inhibitor long pentraxin PTX3 forms an asymmetric octamer with two binding sites for FGF2. J Biol Chem. 2010;285:17681-92 pubmed publisher..Thus, these studies provide a unifying model of the PTX3 oligomer, explaining both its quaternary organization and how this is required for its antiangiogenic function. ..
- Benson M, Tinsley C, Blake D. Myospryn is a novel binding partner for dysbindin in muscle. J Biol Chem. 2004;279:10450-8 pubmed..These data demonstrate for the first time that there are tissue-specific ligands for dysbindin that may play important roles in the different disease states involving this protein. ..
- Kukimoto I, Elderkin S, Grimaldi M, OELGESCHLAGER T, Varga Weisz P. The histone-fold protein complex CHRAC-15/17 enhances nucleosome sliding and assembly mediated by ACF. Mol Cell. 2004;13:265-77 pubmed
- Cuomo M, Knebel A, Platt G, Morrice N, Cohen P, Mittnacht S. Regulation of microfilament organization by Kaposi sarcoma-associated herpes virus-cyclin.CDK6 phosphorylation of caldesmon. J Biol Chem. 2005;280:35844-58 pubmed..These results establish a novel link between KSHV infection and the regulation of the actin cytoskeleton. ..
- Mulvihill D, Edwards S, Hyams J. A critical role for the type V myosin, Myo52, in septum deposition and cell fission during cytokinesis in Schizosaccharomyces pombe. Cell Motil Cytoskeleton. 2006;63:149-61 pubmed..On the commencement of septum formation, Myo52 transports Bgs1 to the cell equator, thus ensuring the accurate deposition of beta-1,3-glucan at the leading edge of the primary septum. ..
- Yang J, Groen A, Lemeer S, Jans A, Slijper M, Roe S, et al. Reversible oxidation of the membrane distal domain of receptor PTPalpha is mediated by a cyclic sulfenamide. Biochemistry. 2007;46:709-19 pubmed..Conformational changes associated with RPTPalpha D2 oxidation have implications for RPTPalpha quaternary structure and allosteric regulation of D1 phosphatase activity. ..
- Vallier L, Alexander M, Pedersen R. Conditional gene expression in human embryonic stem cells. Stem Cells. 2007;25:1490-7 pubmed..Disclosure of potential conflicts of interest is found at the end of this article. ..
- Wasmuth J, Schmid R, Hedley A, Blaxter M. On the extent and origins of genic novelty in the phylum Nematoda. PLoS Negl Trop Dis. 2008;2:e258 pubmed publisher..These classes of genes may underpin parasitic phenotypes, and thus may be targets for development of effective control measures. ..
- Johnson K, Faulkner C, Jeffree C, Ingram G. The phytocalpain defective kernel 1 is a novel Arabidopsis growth regulator whose activity is regulated by proteolytic processing. Plant Cell. 2008;20:2619-30 pubmed publisher..This analysis of the novel phenotypes produced by DEK1 under- and overexpression, as well as DEK1 subcellular localization and protein processing, has revealed a fundamental role for DEK1-mediated signaling in growth regulation. ..
- Clifton I, Doan L, Sleeman M, Topf M, Suzuki H, Wilmouth R, et al. Crystal structure of carbapenem synthase (CarC). J Biol Chem. 2003;278:20843-50 pubmed..The combined work will stimulate further mechanistic studies and aid in the engineering of carbapenem biosynthesis. ..
- Dong C, Major L, Allen A, Blankenfeldt W, Maskell D, Naismith J. High-resolution structures of RmlC from Streptococcus suis in complex with substrate analogs locate the active site of this class of enzyme. Structure. 2003;11:715-23 pubmed..suis enzyme has similar kinetic properties and structure to other RmlC enzymes. Structure, sequence alignment, and mutational analysis have now allowed reliable identification of the catalytic residues and their roles. ..
- Bowles C, Wilkinson I, Smith R, Moir A, Montgomery H, Ross R. Membrane reinsertion of a myristoyl-peptidyl anchored extracellular domain growth hormone receptor. Endocrinology. 2007;148:824-30 pubmed..Truncated extracellular domain GHR can, when specifically modified with a membrane-localizing mp unit, insert into cell surface membranes and modulate GHR signaling. ..
- Carafoli F, Clout N, Hohenester E. Crystal structure of the LG1-3 region of the laminin alpha2 chain. J Biol Chem. 2009;284:22786-92 pubmed publisher..The alpha 2LG1-3 structure provides the first atomic view of the integrin binding region of laminins. ..
- Brodbeck J, Davies A, Courtney J, Meir A, Balaguero N, Canti C, et al. The ducky mutation in Cacna2d2 results in altered Purkinje cell morphology and is associated with the expression of a truncated alpha 2 delta-2 protein with abnormal function. J Biol Chem. 2002;277:7684-93 pubmed..1/beta(4) channel combination when co-expressed in vitro, co-expression with the truncated mutant alpha 2 delta-2 protein reduced current density, indicating that it may contribute to the du phenotype. ..