Experts and Doctors on tertiary protein structure in Austria

Summary

Locale: Austria
Topic: tertiary protein structure

Top Publications

  1. Schlangen K, Miosic S, Thill J, Halbwirth H. Cloning, functional expression, and characterization of a chalcone 3-hydroxylase from Cosmos sulphureus. J Exp Bot. 2010;61:3451-9 pubmed publisher
    ..This is the first identification of a CH3H cDNA from any plant species. ..
  2. Hasselblatt H, Kurzbauer R, Wilken C, Krojer T, Sawa J, Kurt J, et al. Regulation of the sigmaE stress response by DegS: how the PDZ domain keeps the protease inactive in the resting state and allows integration of different OMP-derived stress signals upon folding stress. Genes Dev. 2007;21:2659-70 pubmed
    ..Thus, the PDZ domain and loop L3 of DegS define a novel molecular switch allowing strict regulation of the sigmaE stress response system. ..
  3. Panizza S, Tanaka T, Hochwagen A, Eisenhaber F, Nasmyth K. Pds5 cooperates with cohesin in maintaining sister chromatid cohesion. Curr Biol. 2000;10:1557-64 pubmed
  4. Rovina P, Jaritz M, Höfinger S, Graf C, Devay P, Billich A, et al. A critical beta6-beta7 loop in the pleckstrin homology domain of ceramide kinase. Biochem J. 2006;400:255-65 pubmed
    ..This is in contrast with most PH domains whose function strongly relies on charges located in the beta1-beta2 loop. ..
  5. Furst J, Schedlbauer A, Gandini R, Garavaglia M, Saino S, Gschwentner M, et al. ICln159 folds into a pleckstrin homology domain-like structure. Interaction with kinases and the splicing factor LSm4. J Biol Chem. 2005;280:31276-82 pubmed
    ..Furthermore, ICln159 interacts with LSm4, a protein involved in splicing and mRNA degradation, suggesting that the ICln159 PH domain may serve as a protein-protein interaction platform. ..
  6. Zakalskiy A, Högenauer G, Ishikawa T, Wehrschütz Sigl E, Wendler F, Teis D, et al. Structural and enzymatic properties of the AAA protein Drg1p from Saccharomyces cerevisiae. Decoupling of intracellular function from ATPase activity and hexamerization. J Biol Chem. 2002;277:26788-95 pubmed
    ..These observations are discussed in terms of the inter-relationship of ATPase activity per se, oligomeric status, and intracellular function for AAA proteins. ..
  7. Foeger N, Glaser W, Skern T. Recognition of eukaryotic initiation factor 4G isoforms by picornaviral proteinases. J Biol Chem. 2002;277:44300-9 pubmed
    ..These experiments strongly suggest a novel interaction between picornaviral proteinases and eIF4G isoforms. ..
  8. Doyle M, Jantsch M. Distinct in vivo roles for double-stranded RNA-binding domains of the Xenopus RNA-editing enzyme ADAR1 in chromosomal targeting. J Cell Biol. 2003;161:309-19 pubmed
  9. Fuhrmann J, Schmidt A, Spiess S, Lehner A, Turgay K, Mechtler K, et al. McsB is a protein arginine kinase that phosphorylates and inhibits the heat-shock regulator CtsR. Science. 2009;324:1323-7 pubmed publisher
    ..Identification of the CtsR/McsB arginine phospho-switch expands the repertoire of possible protein modifications involved in prokaryotic and eukaryotic transcriptional regulation. ..

More Information

Publications106 found, 100 shown here

  1. Hazemi P, Tzotzos S, Fischer B, Andavan G, Fischer H, Pietschmann H, et al. Essential structural features of TNF-? lectin-like domain derived peptides for activation of amiloride-sensitive sodium current in A549 cells. J Med Chem. 2010;53:8021-9 pubmed publisher
    ..Ventilation strategies apart, no standard treatment exists for pulmonary permeability edema. Therefore, novel therapies activating sodium uptake from the alveolar fluid via ENaC could improve clinical outcome. ..
  2. Harant H, Lettner N, Hofer L, Oberhauser B, de Vries J, Lindley I. The translocation inhibitor CAM741 interferes with vascular cell adhesion molecule 1 signal peptide insertion at the translocon. J Biol Chem. 2006;281:30492-502 pubmed
    ..Our data indicate that the compound inhibits translocation of VCAM1 by interfering with correct insertion of its signal peptide into the translocon. ..
  3. Unterberger U, Hoftberger R, Gelpi E, Flicker H, Budka H, Voigtlander T. Endoplasmic reticulum stress features are prominent in Alzheimer disease but not in prion diseases in vivo. J Neuropathol Exp Neurol. 2006;65:348-57 pubmed
    ..The lack of prominent activation of the PERK-eIF2alpha pathway in prion diseases suggests that, in contrast to AD, ER stress does not play a crucial role in neuronal death in prion disorders. ..
  4. Hammel M, Kriechbaum M, Gries A, Kostner G, Laggner P, Prassl R. Solution structure of human and bovine beta(2)-glycoprotein I revealed by small-angle X-ray scattering. J Mol Biol. 2002;321:85-97 pubmed
  5. Weinhofer I, Kunze M, Rampler H, Bookout A, Forss Petter S, Berger J. Liver X receptor alpha interferes with SREBP1c-mediated Abcd2 expression. Novel cross-talk in gene regulation. J Biol Chem. 2005;280:41243-51 pubmed
    ..Together, we identify LXRalpha as negative modulator of Abcd2, acting through a novel regulatory mechanism involving overlapping SREBP and LXRalpha binding sites...
  6. Szabo Z, Obermair G, Cooper C, Zamponi G, Flucher B. Role of the synprint site in presynaptic targeting of the calcium channel CaV2.2 in hippocampal neurons. Eur J Neurosci. 2006;24:709-18 pubmed
    ..The unique targeting properties of the splice variants lacking the synprint site are suggestive of specific functions of these calcium channels apart from activating fast synaptic transmission. ..
  7. Schnorrer F, Kalchhauser I, Dickson B. The transmembrane protein Kon-tiki couples to Dgrip to mediate myotube targeting in Drosophila. Dev Cell. 2007;12:751-66 pubmed
    ..Forced overexpression of Kon stimulates muscle motility. We propose that Kon promotes directed myotube migration and transduces a target-derived signal that initiates the formation of a stable connection. ..
  8. Gille L, Nohl H. The ubiquinol/bc1 redox couple regulates mitochondrial oxygen radical formation. Arch Biochem Biophys. 2001;388:34-8 pubmed
    ..The regulator which controls leakage of electrons to oxygen appears to be the electron branching activity of the bc1 complex. ..
  9. Reitinger S, Müllegger J, Greiderer B, Nielsen J, Lepperdinger G. Designed human serum hyaluronidase 1 variant, HYAL1DeltaL, exhibits activity up to pH 5.9. J Biol Chem. 2009;284:19173-7 pubmed publisher
    ..This variant exhibited hyaluronan degradation at elevated pH. This is indicative for appropriate substrate binding and proper positioning being decisively affected by sites far off from the active center. ..
  10. Orlinger K, Hoenninger V, Kofler R, Mandl C. Construction and mutagenesis of an artificial bicistronic tick-borne encephalitis virus genome reveals an essential function of the second transmembrane region of protein e in flavivirus assembly. J Virol. 2006;80:12197-208 pubmed publisher
    ..Deletion analysis and replacement of the entire TBEV E-TM2 region with its counterpart from another flavivirus revealed that this element, apart from its role as a signal sequence, is important for virion formation...
  11. Giefing C, Jelencsics K, Gelbmann D, Senn B, Nagy E. The pneumococcal eukaryotic-type serine/threonine protein kinase StkP co-localizes with the cell division apparatus and interacts with FtsZ in vitro. Microbiology. 2010;156:1697-707 pubmed publisher
    ..Based on its cell-division-dependent localization and interaction with FtsZ, we propose that StkP plays a currently undefined role in cell division of pneumococcus. ..
  12. Novatchkova M, Leibbrandt A, Werzowa J, Neubüser A, Eisenhaber F. The STIR-domain superfamily in signal transduction, development and immunity. Trends Biochem Sci. 2003;28:226-9 pubmed
    ..By analogy, we suggest that SEFIR-domain proteins function as signalling components of Toll/IL-1R-similar pathways and that their SEFIR domain mediates physical protein-protein interactions between pathway components. ..
  13. Spahn L, Siligan C, Bachmaier R, Schmid J, Aryee D, Kovar H. Homotypic and heterotypic interactions of EWS, FLI1 and their oncogenic fusion protein. Oncogene. 2003;22:6819-29 pubmed
    ..Therefore, the functional consequences of homo- and hetero-oligomerization of EWS and EWS-FLI1 proteins remain to be elucidated. ..
  14. Novatchkova M, Bachmair A, Eisenhaber B, Eisenhaber F. Proteins with two SUMO-like domains in chromatin-associated complexes: the RENi (Rad60-Esc2-NIP45) family. BMC Bioinformatics. 2005;6:22 pubmed
    ..This presumption is supported by parallels in the spectrum of modified or bound proteins e.g. transcription factors and chromatin-associated proteins and in the recruitment of HDAC-activity. ..
  15. Griffioen G, Branduardi P, Ballarini A, Anghileri P, Norbeck J, Baroni M, et al. Nucleocytoplasmic distribution of budding yeast protein kinase A regulatory subunit Bcy1 requires Zds1 and is regulated by Yak1-dependent phosphorylation of its targeting domain. Mol Cell Biol. 2001;21:511-23 pubmed
    ..Altogether, these results suggest that Zds1-mediated cytoplasmic localization of Bcy1 is regulated by carbon source-dependent phosphorylation of cluster II serines, while cluster I acts in a Zds1-independent manner. ..
  16. Oberer M, Zangger K, Prytulla S, Keller W. The anti-toxin ParD of plasmid RK2 consists of two structurally distinct moieties and belongs to the ribbon-helix-helix family of DNA-binding proteins. Biochem J. 2002;361:41-7 pubmed
    ..This is the first experimental evidence that the DNA-binding domain of ParD belongs to the ribbon-helix-helix fold family, and this structural motif is proposed to be present in functionally similar antidote proteins...
  17. Niederost B, Oertle T, Fritsche J, McKinney R, Bandtlow C. Nogo-A and myelin-associated glycoprotein mediate neurite growth inhibition by antagonistic regulation of RhoA and Rac1. J Neurosci. 2002;22:10368-76 pubmed
    ..Furthermore, we show that the recently cloned receptor for Nogo-66 and MAG, NgR, is not necessary for either NiG- or MAG-induced RhoA activation. ..
  18. Tatzer V, Zellnig G, Kohlwein S, Schneiter R. Lipid-dependent subcellular relocalization of the acyl chain desaturase in yeast. Mol Biol Cell. 2002;13:4429-42 pubmed
    ..A model is discussed in which the accumulation of saturated lipids in a microdomain around the desaturase could induce the observed segregation and relocalization of the enzyme. ..
  19. Mairhofer M, Steiner M, Salzer U, Prohaska R. Stomatin-like protein-1 interacts with stomatin and is targeted to late endosomes. J Biol Chem. 2009;284:29218-29 pubmed publisher
    ..This massive cholesterol accumulation clearly depends on the SCP-2 domain of SLP-1, suggesting a role for this domain in cholesterol transfer to late endosomes...
  20. Nikolic B, Mac Nulty E, Mir B, Wiche G. Basic amino acid residue cluster within nuclear targeting sequence motif is essential for cytoplasmic plectin-vimentin network junctions. J Cell Biol. 1996;134:1455-67 pubmed
  21. Sucic S, Dallinger S, Zdrazil B, Weissensteiner R, Jørgensen T, Holy M, et al. The N terminus of monoamine transporters is a lever required for the action of amphetamines. J Biol Chem. 2010;285:10924-38 pubmed publisher
    ..Either modification abolished amphetamine-induced efflux. We therefore conclude that the N terminus of monoamine transporters acts as a lever that sustains reverse transport. ..
  22. Rea S, Eisenhaber F, O Carroll D, Strahl B, Sun Z, Schmid M, et al. Regulation of chromatin structure by site-specific histone H3 methyltransferases. Nature. 2000;406:593-9 pubmed
    ..Our data reveal a functional interdependence of site-specific H3 tail modifications and suggest a dynamic mechanism for the regulation of higher-order chromatin. ..
  23. Noiges R, Eichinger R, Kutschera W, Fischer I, Nemeth Z, Wiche G, et al. Microtubule-associated protein 1A (MAP1A) and MAP1B: light chains determine distinct functional properties. J Neurosci. 2002;22:2106-14 pubmed
  24. Haering C, L we J, Hochwagen A, Nasmyth K. Molecular architecture of SMC proteins and the yeast cohesin complex. Mol Cell. 2002;9:773-88 pubmed
    ..The two heads of the V-shaped dimer are connected by different ends of the cleavable Scc1 subunit. Cohesin therefore forms a large proteinaceous loop within which sister chromatids might be entrapped after DNA replication...
  25. Steinrigl A, Nosek D, Ertl R, Gunzburg W, Salmons B, Klein D. Mutations in the catalytic core or the C-terminus of murine leukemia virus (MLV) integrase disrupt virion infectivity and exert diverse effects on reverse transcription. Virology. 2007;362:50-9 pubmed
    ..Deletion of either the IN C-terminus alone, or in addition to part of the catalytic domain exerted contrasting effects on intracellular viral DNA levels, implying that IN influences reverse transcription in more than one direction. ..
  26. Wille I, Rek A, Krenn E, Kungl A. Biophysical investigation of human heparan sulfate D-glucosaminyl 3-O-sulfotransferase-3A: a mutual effect of enzyme oligomerisation and glycosaminoglycan ligand binding. Biochim Biophys Acta. 2007;1774:1470-6 pubmed
    ..We therefore conclude that since 3-OST-3A is able to bind also non-substrate GAG ligands with high affinity, discrimination among ligands is triggered by protein oligomerisation. ..
  27. Haering C, Nasmyth K. Building and breaking bridges between sister chromatids. Bioessays. 2003;25:1178-91 pubmed
    ..New research suggests that these ancient regulators of chromosome structure might function as topological devices that trap chromosomal DNA between 50 nm long coiled coils. ..
  28. Korkhov V, Farhan H, Freissmuth M, Sitte H. Oligomerization of the {gamma}-aminobutyric acid transporter-1 is driven by an interplay of polar and hydrophobic interactions in transmembrane helix II. J Biol Chem. 2004;279:55728-36 pubmed
  29. Keleman K, Ribeiro C, Dickson B. Comm function in commissural axon guidance: cell-autonomous sorting of Robo in vivo. Nat Neurosci. 2005;8:156-63 pubmed
    ..We show here, however, that ubiquitination of Comm is not required for its function in vitro or in vivo, and that Nedd4 is unlikely to function in axon guidance at the midline. ..
  30. Morandell D, Rostek U, Bouvard V, Campo Fernandez B, Fiedler M, Jansen Durr P, et al. Human papillomavirus type 45 E7 is a transforming protein inducing retinoblastoma protein degradation and anchorage-independent cell cycle progression. Virology. 2008;379:20-9 pubmed publisher
    ..In summary, these data suggest that HPV-45 E7 is a transforming protein and that abrogation of cell cycle control contributes to its oncogenic potential. ..
  31. Wallner S, Neuwirth M, Flicker K, Tews I, Macheroux P. Dissection of contributions from invariant amino acids to complex formation and catalysis in the heteromeric pyridoxal 5-phosphate synthase complex from Bacillus subtilis. Biochemistry. 2009;48:1928-35 pubmed publisher
    ..However, the main players for formation of the Michaelis complex reside on Pdx2, as replacement of residues at the N-terminal face of the (betaalpha)(8) barrel of Pdx1 leads to reduction but not complete inactivation of the glutaminase. ..
  32. Ellis T, Gambardella L, Horcher M, Tschanz S, Capol J, Bertram P, et al. The transcriptional repressor CDP (Cutl1) is essential for epithelial cell differentiation of the lung and the hair follicle. Genes Dev. 2001;15:2307-19 pubmed
    ..These data implicate CDP in cell-lineage specification during hair follicle morphogenesis, which resembles the role of the related Cut protein in specifying cell fates during Drosophila development. ..
  33. Polgar D, Leisser C, Maier S, Strasser S, Rüger B, Dettke M, et al. Truncated ALK derived from chromosomal translocation t(2;5)(p23;q35) binds to the SH3 domain of p85-PI3K. Mutat Res. 2005;570:9-15 pubmed
    ..Here we provide evidence that the truncated ALK homodimer binds to the SH3 domain of p85. This finding may be useful for the development of a new target-specific intervention. ..
  34. Eichberger T, Kaser A, Pixner C, Schmid C, Klingler S, Winklmayr M, et al. GLI2-specific transcriptional activation of the bone morphogenetic protein/activin antagonist follistatin in human epidermal cells. J Biol Chem. 2008;283:12426-37 pubmed publisher
  35. Rajakumari S, Daum G. Multiple functions as lipase, steryl ester hydrolase, phospholipase, and acyltransferase of Tgl4p from the yeast Saccharomyces cerevisiae. J Biol Chem. 2010;285:15769-76 pubmed publisher
    ..Altogether, our data suggest that yeast Tgl4p functions as a hydrolytic enzyme in lipid degradation but also contributes to fatty acid channeling and phospholipid remodeling. ..
  36. Knöfler M, Meinhardt G, Bauer S, Loregger T, Vasicek R, Bloor D, et al. Human Hand1 basic helix-loop-helix (bHLH) protein: extra-embryonic expression pattern, interaction partners and identification of its transcriptional repressor domains. Biochem J. 2002;361:641-51 pubmed
    ..Furthermore, the data suggest that Hand1 can act as a repressor by two independent mechanisms; sequestration of class A bHLH factors from E-boxes and inhibition of their transcriptional activity. ..
  37. Plaimauer B, Mohr G, Wernhart W, Himmelspach M, Dorner F, Schlokat U. 'Shed' furin: mapping of the cleavage determinants and identification of its C-terminus. Biochem J. 2001;354:689-95 pubmed
    ..MS analysis determined Ser(682) as the C-terminus of shed furin, suggesting that monobasic cleavage may occur N-terminal to Arg(683). Alteration of Arg(683) directs the shedding mechanism to alternative cleaving sites previously unused. ..
  38. Taplick J, Kurtev V, Kroboth K, Posch M, Lechner T, Seiser C. Homo-oligomerisation and nuclear localisation of mouse histone deacetylase 1. J Mol Biol. 2001;308:27-38 pubmed
    ..Our results define two domains, which are essential for the oligomerisation and nuclear localisation of mouse HDAC1. ..
  39. Offterdinger M, Schöfer C, Weipoltshammer K, Grunt T. c-erbB-3: a nuclear protein in mammary epithelial cells. J Cell Biol. 2002;157:929-39 pubmed
  40. Farhan H, Korkhov V, Paulitschke V, Dorostkar M, Scholze P, Kudlacek O, et al. Two discontinuous segments in the carboxyl terminus are required for membrane targeting of the rat gamma-aminobutyric acid transporter-1 (GAT1). J Biol Chem. 2004;279:28553-63 pubmed
  41. Kurtev V, Margueron R, Kroboth K, Ogris E, Cavailles V, Seiser C. Transcriptional regulation by the repressor of estrogen receptor activity via recruitment of histone deacetylases. J Biol Chem. 2004;279:24834-43 pubmed
    ..We, therefore, propose a novel function for REA as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. ..
  42. Haering C, Schoffnegger D, Nishino T, Helmhart W, Nasmyth K, Lowe J. Structure and stability of cohesin's Smc1-kleisin interaction. Mol Cell. 2004;15:951-64 pubmed
    ..There is little or no turnover of Smc1-Scc1 interactions within cohesin complexes in vivo because expression of noncleavable Scc1 after DNA replication does not hinder anaphase. ..
  43. Kraft C, Vodermaier H, Maurer Stroh S, Eisenhaber F, Peters J. The WD40 propeller domain of Cdh1 functions as a destruction box receptor for APC/C substrates. Mol Cell. 2005;18:543-53 pubmed
    ..Our data imply that APC/C is activated by the association of Cdh1 with Cdc27, which enables APC/C to recognize the D box of substrates via Cdh1's propeller domain. ..
  44. Schmidt W, Kraus C, Hoger H, Hochmeister S, Oberndorfer F, Branka M, et al. Mutation in the Scyl1 gene encoding amino-terminal kinase-like protein causes a recessive form of spinocerebellar neurodegeneration. EMBO Rep. 2007;8:691-7 pubmed
    ..We show that the pathology of mdf comprises cerebellar atrophy, Purkinje cell loss and optic nerve atrophy, and therefore defines a new animal model for neurodegenerative diseases with cerebellar involvement in humans. ..
  45. Sandholzer J, Hoeth M, Piskacek M, Mayer H, de Martin R. A novel 9-amino-acid transactivation domain in the C-terminal part of Sox18. Biochem Biophys Res Commun. 2007;360:370-4 pubmed
    ..These result can explain previously controversial data on the functional consequences of Sox18 mutations in mice and humans. ..
  46. Snyers L, Schöfer C. Lamina-associated polypeptide 2alpha forms complexes with heat shock proteins Hsp70 and Hsc70 in vivo. Biochem Biophys Res Commun. 2008;368:767-71 pubmed publisher
    ..Association between endogenous LAP2alpha and Hsp70 in non-transfected cells was confirmed by co-immunoprecipitation. The association was not mediated by the retinoblastoma protein. ..
  47. Sadzak I, Schiff M, Gattermeier I, Glinitzer R, Sauer I, Saalmuller A, et al. Recruitment of Stat1 to chromatin is required for interferon-induced serine phosphorylation of Stat1 transactivation domain. Proc Natl Acad Sci U S A. 2008;105:8944-9 pubmed publisher
    ..This control mechanism, which may be used by other Stat proteins as well, restricts the final activation step to the chromatin-tethered transcription factor. ..
  48. Rovina P, Schanzer A, Graf C, Mechtcheriakova D, Jaritz M, Bornancin F. Subcellular localization of ceramide kinase and ceramide kinase-like protein requires interplay of their Pleckstrin Homology domain-containing N-terminal regions together with C-terminal domains. Biochim Biophys Acta. 2009;1791:1023-30 pubmed publisher
    ..It further suggests a nucleocytoplasmic shuttling mechanism for both proteins that may be defective in CERKL mutant proteins responsible for retinal degenerative diseases. ..
  49. Derler I, Fahrner M, Muik M, Lackner B, Schindl R, Groschner K, et al. A Ca2(+ )release-activated Ca2(+) (CRAC) modulatory domain (CMD) within STIM1 mediates fast Ca2(+)-dependent inactivation of ORAI1 channels. J Biol Chem. 2009;284:24933-8 pubmed publisher
    ..In summary, CMD within the STIM1 cytosolic part provides a negative feedback signal to Ca(2+) entry by triggering fast Ca(2+)-dependent inactivation of ORAI/CRAC channels. ..
  50. Dayal A, Schredelseker J, Franzini Armstrong C, Grabner M. Skeletal muscle excitation-contraction coupling is independent of a conserved heptad repeat motif in the C-terminus of the DHPRbeta(1a) subunit. Cell Calcium. 2010;47:500-6 pubmed publisher
  51. Steinböck F, Nikolic B, Coulombe P, Fuchs E, Traub P, Wiche G. Dose-dependent linkage, assembly inhibition and disassembly of vimentin and cytokeratin 5/14 filaments through plectin's intermediate filament-binding domain. J Cell Sci. 2000;113 ( Pt 3):483-91 pubmed
    ..Our results suggest an involvement of plectin not only in crosslinking and stabilization of cytoskeletal IF networks, but also in regulation of their dynamics. ..
  52. Pankevych H, Korkhov V, Freissmuth M, Nanoff C. Truncation of the A1 adenosine receptor reveals distinct roles of the membrane-proximal carboxyl terminus in receptor folding and G protein coupling. J Biol Chem. 2003;278:30283-93 pubmed
    ..Thus, the distal portion of the carboxyl terminus provides for an autoinhibitory restraint, presumably by folding back and preventing G protein access to the proximal part of the C-tail. ..
  53. Bajari T, Strasser V, Nimpf J, Schneider W. A model for modulation of leptin activity by association with clusterin. FASEB J. 2003;17:1505-7 pubmed
    ..Thus, bioavailability of leptin at a given tissue site may be determined by the levels of clusterin and/or by the relative distribution of certain relatives of the LDL receptor vis-à-vis active leptin receptors. ..
  54. Mishima M, Pavicic V, Gruneberg U, Nigg E, Glotzer M. Cell cycle regulation of central spindle assembly. Nature. 2004;430:908-13 pubmed
    ..Thus, phosphoregulation of the motor domain of MKLP1 kinesin ensures that central spindle assembly occurs at the appropriate time in the cell cycle and maintains genomic stability. ..
  55. Kitzing K, Fitzpatrick T, Wilken C, Sawa J, Bourenkov G, Macheroux P, et al. The 1.3 A crystal structure of the flavoprotein YqjM reveals a novel class of Old Yellow Enzymes. J Biol Chem. 2005;280:27904-13 pubmed
    ..Therefore, YqjM is the first representative of a new bacterial subfamily of OYE homologs. ..
  56. Wachek M, Aichinger M, Stadler J, Schweyen R, Graschopf A. Oligomerization of the Mg2+-transport proteins Alr1p and Alr2p in yeast plasma membrane. FEBS J. 2006;273:4236-49 pubmed
    ..These assays also show that both the N-terminus and C-terminus of Alr1p and Alr2p are exposed to the inner side of the plasma membrane. ..
  57. Arumugam P, Nishino T, Haering C, Gruber S, Nasmyth K. Cohesin's ATPase activity is stimulated by the C-terminal Winged-Helix domain of its kleisin subunit. Curr Biol. 2006;16:1998-2008 pubmed
    ..In contrast, we do not detect any effect of Scc1's N-terminal domain on Smc1/Smc3 ATPase activity. Our studies reveal that Scc1 not only connects the Smc1 and Smc3 ATPase heads but also regulates their ATPase activity. ..
  58. Ramsauer K, Farlik M, Zupkovitz G, Seiser C, Kröger A, Hauser H, et al. Distinct modes of action applied by transcription factors STAT1 and IRF1 to initiate transcription of the IFN-gamma-inducible gbp2 gene. Proc Natl Acad Sci U S A. 2007;104:2849-54 pubmed
  59. Gullerova M, Barta A, Lorkovic Z. Rct1, a nuclear RNA recognition motif-containing cyclophilin, regulates phosphorylation of the RNA polymerase II C-terminal domain. Mol Cell Biol. 2007;27:3601-11 pubmed
    ..These data, together with the pleiotropic phenotype upon Rct1 deregulation, suggest that this multidomain cyclophilin is an important player in maintaining the correct phosphorylation code of the CTD and thereby regulating CTD function. ..
  60. Hickel A, Danner Pongratz S, Amenitsch H, Degovics G, Rappolt M, Lohner K, et al. Influence of antimicrobial peptides on the formation of nonlamellar lipid mesophases. Biochim Biophys Acta. 2008;1778:2325-33 pubmed publisher
    ..Both mechanisms prevent transmembrane contact required to form either an inverted hexagonal phase or fusion pores, as precursors of the cubic phase. ..
  61. Sarg B, Chwatal S, Talasz H, Lindner H. Testis-specific linker histone H1t is multiply phosphorylated during spermatogenesis. Identification of phosphorylation sites. J Biol Chem. 2009;284:3610-8 pubmed publisher
    ..Thus, it appears that not the order of up-phosphorylation but the number of the phosphate groups is necessary for regulated chromatin decondensation, thus facilitating the substitution of H1t by transition proteins and protamines. ..
  62. Gruber A, Cornaciu I, Lass A, Schweiger M, Poeschl M, Eder C, et al. The N-terminal region of comparative gene identification-58 (CGI-58) is important for lipid droplet binding and activation of adipose triglyceride lipase. J Biol Chem. 2010;285:12289-98 pubmed publisher
    ..In summary, our study shows that the N-terminal, Trp-rich region of CGI-58 is essential for correct localization and ATGL-activating function of CGI-58. ..
  63. Kim Y, Bartalska K, Audsley N, Yamanaka N, Yapici N, Lee J, et al. MIPs are ancestral ligands for the sex peptide receptor. Proc Natl Acad Sci U S A. 2010;107:6520-5 pubmed publisher
    ..We conclude that MIPs are evolutionarily conserved ligands for SPR, which are likely to mediate functions other than the regulation of female reproductive behaviors. ..
  64. Lunter P, Wiche G. Direct binding of plectin to Fer kinase and negative regulation of its catalytic activity. Biochem Biophys Res Commun. 2002;296:904-10 pubmed
    ..We conclude that Fer interacts with plectin and that this interaction may serve to negatively regulate Fer's activity. ..
  65. Keleman K, Rajagopalan S, Cleppien D, Teis D, Paiha K, Huber L, et al. Comm sorts robo to control axon guidance at the Drosophila midline. Cell. 2002;110:415-27 pubmed
    ..Axon traffic at the CNS midline is thus controlled by the intracellular trafficking of the Robo guidance receptor, which in turn depends on the precisely regulated expression of the Comm sorting receptor. ..
  66. Scholze P, Freissmuth M, Sitte H. Mutations within an intramembrane leucine heptad repeat disrupt oligomer formation of the rat GABA transporter 1. J Biol Chem. 2002;277:43682-90 pubmed
    ..Hence, our findings strongly argue for a role of oligomer formation during biosynthesis and subsequent delivery of the multimer from the endoplasmic reticulum to the plasma membrane. ..
  67. Jisa E, Jungbauer A. Kinetic analysis of estrogen receptor homo- and heterodimerization in vitro. J Steroid Biochem Mol Biol. 2003;84:141-8 pubmed
    ..2 x 10(-8) to 5.4 x 10(-8) and 1.8 x 10(-8) to 2.6 x 10(-8)M for the heterodimer formation. The homo- and heterodimer formation was characterized by a slow association kinetics and kinetic rate constants were within the same range. ..
  68. Nakagawa H, Miki H, Nozumi M, Takenawa T, Miyamoto S, Wehland J, et al. IRSp53 is colocalised with WAVE2 at the tips of protruding lamellipodia and filopodia independently of Mena. J Cell Sci. 2003;116:2577-83 pubmed
    ..These results suggest an alternative modulatory role for IRSp53 in the extension of both filopodia and lamellipodia, through WAVE2. ..
  69. Lorenz A, Wells J, Pryce D, Novatchkova M, Eisenhaber F, McFarlane R, et al. S. pombe meiotic linear elements contain proteins related to synaptonemal complex components. J Cell Sci. 2004;117:3343-51 pubmed
    ..These observations indicate the evolutionary relationship of LEs with the lateral elements of SCs and suggest that these structures might exert similar functions in S. cerevisiae and S. pombe. ..
  70. Harant H, Lindley I. Negative cross-talk between the human orphan nuclear receptor Nur77/NAK-1/TR3 and nuclear factor-kappaB. Nucleic Acids Res. 2004;32:5280-90 pubmed
    ..Our data suggest that Nur77 is able to block activation through NF-kappaB when bound to low-affinity NF-kappaB binding sites, such as those located in the IL-2 promoter. ..
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