Experts and Doctors on sympathetic nervous system in Australia


Locale: Australia
Topic: sympathetic nervous system

Top Publications

  1. Hering D, Marusic P, Walton A, Duval J, Lee R, Sata Y, et al. Renal artery anatomy affects the blood pressure response to renal denervation in patients with resistant hypertension. Int J Cardiol. 2016;202:388-93 pubmed publisher
    ..However, when patients with dual renal arteries received renal nerve ablation in all arteries there was trend towards a greater BP reduction. Insufficient renal sympathetic nerve ablation may account for these differences. ..
  2. Makeham J, Goodchild A, Pilowsky P. NK1 receptor and the ventral medulla of the rat: bulbospinal and catecholaminergic neurons. Neuroreport. 2001;12:3663-7 pubmed
    ..We also demonstrate the NK1 receptor on bulbospinal neurons of the ventral respiratory group, in a region overlapping the pre-Bötzinger Complex. ..
  3. James C, Macefield V, Henderson L. Real-time imaging of cortical and subcortical control of muscle sympathetic nerve activity in awake human subjects. Neuroimage. 2013;70:59-65 pubmed publisher
    ..This suggests that activity within suprabulbar regions may regulate resting MSNA by projections to the premotor sympathetic neurons in the rostroventrolateral medulla. ..
  4. Powis D. Alpha 2-adrenoceptor blockade prevents cardiac glycoside-evoked neurotransmitter release from sympathetic nerves in dog saphenous vein. Br J Pharmacol. 1987;92:213-20 pubmed
    ..7. It is concluded that the cardiac glycoside-evoked increase in neurotransmitter release from noradrenergic nerve terminals ofdog saphenous vein is modulated by a mechanism that involves an alpha2- adrenoceptor. ..
  5. Kashihara K, Kawada T, Sugimachi M, Sunagawa K. Wavelet-based system identification of short-term dynamic characteristics of arterial baroreflex. Ann Biomed Eng. 2009;37:112-28 pubmed publisher
    ..In conclusion, the dynamic baroreflex property to various pressure inputs could be simultaneously extracted from the step responses with background noise. ..
  6. Xing T, Pilowsky P. Acute intermittent hypoxia in rat in vivo elicits a robust increase in tonic sympathetic nerve activity that is independent of respiratory drive. J Physiol. 2010;588:3075-88 pubmed publisher
    ..Sympathetic LTF is not linked to the change in baroreflex function, since the baroreflex appears to be enhanced rather than impaired, but does play an important role in the enhancement of the hypoxic chemoreflex. ..
  7. Iigaya K, Müller Ribeiro F, Horiuchi J, McDowall L, Nalivaiko E, Fontes M, et al. Synchronized activation of sympathetic vasomotor, cardiac, and respiratory outputs by neurons in the midbrain colliculi. Am J Physiol Regul Integr Comp Physiol. 2012;303:R599-610 pubmed publisher
    ..We propose that the synchronized sympathetic-respiratory responses are driven by a common population of neurons, which may normally be activated by an acute threatening stimulus. ..
  8. Ohlsson M, Gordon T, Waterman S. Role of anti-calcium channel and anti-receptor autoantibodies in autonomic dysfunction in Sjögren's syndrome. J Neuroimmunol. 2002;127:127-33 pubmed
  9. Macefield V, Gandevia S, Henderson L. Neural sites involved in the sustained increase in muscle sympathetic nerve activity induced by inspiratory capacity apnea: a fMRI study. J Appl Physiol (1985). 2006;100:266-73 pubmed
    ..Given that many of these sites have roles in cardiovascular control, the sustained increase in MSNA during an inspiratory capacity apnea is likely to originate from a distributed set of discrete areas. ..

More Information


  1. Perkes I, Baguley I, Nott M, Menon D. A review of paroxysmal sympathetic hyperactivity after acquired brain injury. Ann Neurol. 2010;68:126-35 pubmed publisher
    ..The review highlights major problems regarding conceptual definitions, diagnostic criteria, and nomenclature. Consensus on these issues is recommended as an essential basis for further research in the area. ..
  2. Burton A, Birznieks I, Spaak J, Henderson L, Macefield V. Effects of deep and superficial experimentally induced acute pain on skin sympathetic nerve activity in human subjects. Exp Brain Res. 2009;195:317-24 pubmed publisher
    ..We conclude that both acute muscle and skin pain cause an increase in SSNA, sweat release and gender-dependent changes in skin blood flow. ..
  3. Arnolda L, McKitrick D, Llewellyn Smith I, Minson J. Nitric oxide limits pressor responses to sympathetic activation in rat spinal cord. Hypertension. 2000;36:1089-92 pubmed
    ..These results indicate that endogenous synthesis of NO in the spinal cord limits the pressor response to stimulation of spinal NMDA receptors. ..
  4. Lambert E, Straznicky N, Sari C, Eikelis N, Hering D, Head G, et al. Dyslipidemia is associated with sympathetic nervous activation and impaired endothelial function in young females. Am J Hypertens. 2013;26:250-6 pubmed publisher
    ..The sympathetic activation observed in the subjects with an elevated cholesterol profile may play a role in the development of cardiovascular disease development. ..
  5. McMullan S, Pilowsky P. Sympathetic premotor neurones project to and are influenced by neurones in the contralateral rostral ventrolateral medulla of the rat in vivo. Brain Res. 2012;1439:34-43 pubmed publisher
  6. McMullan S, Goodchild A, Pilowsky P. Circulating angiotensin II attenuates the sympathetic baroreflex by reducing the barosensitivity of medullary cardiovascular neurones in the rat. J Physiol. 2007;582:711-22 pubmed
    ..We suggest that this results from activation by Ang II of a central pathway originating at the circumventricular organs. ..
  7. McMullan S, Pathmanandavel K, Pilowsky P, Goodchild A. Somatic nerve stimulation evokes qualitatively different somatosympathetic responses in the cervical and splanchnic sympathetic nerves in the rat. Brain Res. 2008;1217:139-47 pubmed publisher
    ..The results are discussed with regard to the differential control of sympathetic nerve activity. ..
  8. Hirooka Y, Potts P, Dampney R. Role of angiotensin II receptor subtypes in mediating the sympathoexcitatory effects of exogenous and endogenous angiotensin peptides in the rostral ventrolateral medulla of the rabbit. Brain Res. 1997;772:107-14 pubmed
  9. James C, Stathis A, Macefield V. Vestibular and pulse-related modulation of skin sympathetic nerve activity during sinusoidal galvanic vestibular stimulation in human subjects. Exp Brain Res. 2010;202:291-8 pubmed publisher
    ..3 +/- 8.3%), the opposite of the pattern seen with vestibular modulation of MSNA. We conclude that vestibular inputs can entrain the firing of cutaneous sympathetic neurones and increase their normally weak pulse-related rhythmicity. ..
  10. Meyfroidt G, Baguley I, Menon D. Paroxysmal sympathetic hyperactivity: the storm after acute brain injury. Lancet Neurol. 2017;16:721-729 pubmed publisher
    ..New rigorous tools for diagnosis could allow better characterisation of PSH to enable stratification of patients for future therapeutic trials. ..
  11. Schlaich M, Socratous F, Hennebry S, Eikelis N, Lambert E, Straznicky N, et al. Sympathetic activation in chronic renal failure. J Am Soc Nephrol. 2009;20:933-9 pubmed publisher
  12. McDowall L, Horiuchi J, Killinger S, Dampney R. Modulation of the baroreceptor reflex by the dorsomedial hypothalamic nucleus and perifornical area. Am J Physiol Regul Integr Comp Physiol. 2006;290:R1020-6 pubmed
  13. Chen J, Schmid K, Brown B. The autonomic control of accommodation and implications for human myopia development: a review. Ophthalmic Physiol Opt. 2003;23:401-22 pubmed
    ..The collective results of this research point to anomalous accommodation responses, possibly as a result of underlying anomalous autonomic input to the ciliary muscle, being involved in myopia development and progression. ..
  14. Marsh A, Fontes M, Killinger S, Pawlak D, Polson J, Dampney R. Cardiovascular responses evoked by leptin acting on neurons in the ventromedial and dorsomedial hypothalamus. Hypertension. 2003;42:488-93 pubmed
  15. Morris J, Jobling P, Gibbins I. Differential inhibition by botulinum neurotoxin A of cotransmitters released from autonomic vasodilator neurons. Am J Physiol Heart Circ Physiol. 2001;281:H2124-32 pubmed
  16. Horiuchi J, Potts P, Tagawa T, Dampney R. Effects of activation and blockade of P2x receptors in the ventrolateral medulla on arterial pressure and sympathetic activity. J Auton Nerv Syst. 1999;76:118-26 pubmed
  17. Macefield V, Taylor J, Wallin B. Inhibition of muscle sympathetic outflow following transcranial cortical stimulation. J Auton Nerv Syst. 1998;68:49-57 pubmed
  18. Blackshaw L, Dent J. Lower oesophageal sphincter responses to noxious oesophageal chemical stimuli in the ferret: involvement of tachykinin receptors. J Auton Nerv Syst. 1997;66:189-200 pubmed
    ..These data indicate that intra-oesophageal acid causes substance P release from extrinsic afferent nerve endings which activates local inhibitory pathways to the LOS via NK-1 receptors. ..