Experts and Doctors on species specificity in United States


Locale: United States
Topic: species specificity

Top Publications

  1. Lepak A, Marchillo K, VanHecker J, Diekema D, Andes D. Isavuconazole pharmacodynamic target determination for Candida species in an in vivo murine disseminated candidiasis model. Antimicrob Agents Chemother. 2013;57:5642-8 pubmed publisher
    ..The lower PD targets for these species in this model will be important to consider in the analysis of clinical trial data and during the development of susceptibility breakpoints. ..
  2. Dohms J, Hnatow L, Whetzel P, Morgan R, Keeler C. Identification of the putative cytadhesin gene of Mycoplasma gallisepticum and its use as a DNA probe. Avian Dis. 1993;37:380-8 pubmed
    ..However, it failed to hybridize to M. synoviae, M. meleagridis, M. iowae, or M. gallinarum DNA. ..
  3. Gaut B, Clegg M. Molecular evolution of the Adh1 locus in the genus Zea. Proc Natl Acad Sci U S A. 1993;90:5095-9 pubmed
    ..On the basis of previous estimates of nucleotide diversity at other maize loci, it appears that the common ancestor to the genus Zea was polymorphic at many loci. ..
  4. Herman J, Watson S, Spencer R. Defense of adrenocorticosteroid receptor expression in rat hippocampus: effects of stress and strain. Endocrinology. 1999;140:3981-91 pubmed
    ..Overall, stable expression of adrenocorticosteroid receptors is rigorously defended in hippocampal neurons, apparently through transcriptional and posttranscriptional mechanisms. ..
  5. Park Y, Zitnan D, Gill S, Adams M. Molecular cloning and biological activity of ecdysis-triggering hormones in Drosophila melanogaster. FEBS Lett. 1999;463:133-8 pubmed
    ..Identification of eth in Drosophila provides opportunities for genetic manipulation of endocrine and behavioral events underlying a stereotypic behavior. ..
  6. Hain H, Crabbe J, Bergeson S, Belknap J. Cocaine-induced seizure thresholds: quantitative trait loci detection and mapping in two populations derived from the C57BL/6 and DBA/2 mouse strains. J Pharmacol Exp Ther. 2000;293:180-7 pubmed
    ..0015), both associated with clonic seizures on chromosomes 9 (proximal) and 15 (distal). Both QTLs on chromosome 9 were sex-specific, with much larger effects on the phenotype seen in females than in males. ..
  7. Lo L, Dormand E, Greenwood A, Anderson D. Comparison of the generic neuronal differentiation and neuron subtype specification functions of mammalian achaete-scute and atonal homologs in cultured neural progenitor cells. Development. 2002;129:1553-67 pubmed
    ..These properties may explain cellular differences between MASH1- and NGN-dependent lineages in the timing of neuronal differentiation and cell cycle exit. ..
  8. Ashfield T, Ong L, Nobuta K, Schneider C, Innes R. Convergent evolution of disease resistance gene specificity in two flowering plant families. Plant Cell. 2004;16:309-18 pubmed
    ..We conclude that convergent evolution, rather than the conservation of an ancient specificity, is responsible for the generation of these AvrB-specific genes. ..
  9. Saini H, Fischer D. Structural and functional insights into Mimivirus ORFans. BMC Genomics. 2007;8:115 pubmed
    ..Further computational and experimental studies are required to elucidate the 3D structures and functions of the remaining Mimivirus ORFans. ..

More Information

Publications573 found, 100 shown here

  1. Anderson T, Ritchie M, McNaughton S. Rainfall and soils modify plant community response to grazing in Serengeti National Park. Ecology. 2007;88:1191-201 pubmed
    ..We show that herbivore effects on soil P may be an important and previously unappreciated mechanism by which herbivores influence plant diversity, at least in tropical grasslands. ..
  2. Stone D, Liu Y, Li Z, Tuve S, Strauss R, Lieber A. Comparison of adenoviruses from species B, C, E, and F after intravenous delivery. Mol Ther. 2007;15:2146-53 pubmed
    ..Overall, our data indicate that Ad5-based vectors are relatively safe as compared to other serotypes. This data should be taken into consideration in future studies about the clinical use of Ad vectors. ..
  3. Egan S, Ott J. Host plant quality and local adaptation determine the distribution of a gall-forming herbivore. Ecology. 2007;88:2868-79 pubmed
  4. Papandrea D, Kukol W, Anderson T, Herron B, Ferland R. Analysis of flurothyl-induced myoclonus in inbred strains of mice. Epilepsy Res. 2009;87:130-6 pubmed publisher
    ..An understanding of the genetics of myoclonus will be important for determination of the brain areas responsible for myoclonus as well as for identification of candidate genes...
  5. Law L, Gardner R, Allen T, Lee D. Species-specific injury-induced cell proliferation in the hippocampus and subventricular zone of food-storing and nonstoring wild birds. Dev Neurobiol. 2010;70:16-27 pubmed publisher
    ..These species differences may provide a useful model for isolating factors involved in cellular responses following injury. ..
  6. Peterson G, Bai J, Nagaraja T, Narayanan S. Diagnostic microarray for human and animal bacterial diseases and their virulence and antimicrobial resistance genes. J Microbiol Methods. 2010;80:223-30 pubmed publisher
  7. Mustroph A, Lee S, Oosumi T, Zanetti M, Yang H, Ma K, et al. Cross-kingdom comparison of transcriptomic adjustments to low-oxygen stress highlights conserved and plant-specific responses. Plant Physiol. 2010;152:1484-500 pubmed publisher
    ..These findings illuminate both broadly conserved and plant-specific low-oxygen stress responses and confirm that plant-specific HUPs with limited phylogenetic distribution influence low-oxygen stress endurance. ..
  8. Wang Z, Chapman E. Rat and Drosophila synaptotagmin 4 have opposite effects during SNARE-catalyzed membrane fusion. J Biol Chem. 2010;285:30759-66 pubmed publisher
    ..In summary, rat SYT4 serves as an inhibitory isoform, whereas fly SYT4 is a bona fide Ca(2+) sensor capable of coupling Ca(2+) to membrane fusion. ..
  9. Edwards J, Alore E, Rappleye C. The yeast-phase virulence requirement for ?-glucan synthase differs among Histoplasma capsulatum chemotypes. Eukaryot Cell. 2011;10:87-97 pubmed publisher
    ..This suggests the production of a unique Histoplasma chemotype I factor that, at least partially, circumvents the ?-(1,3)-glucan requirement for yeast virulence. ..
  10. Wayne M, Pienaar J, Telonis Scott M, Sylvestre L, Nuzhdin S, McIntyre L. Expression of defense genes in Drosophila evolves under a different selective regime from expression of other genes. Evolution. 2011;65:1068-78 pubmed publisher
    ..Both balancing selection driven by host-pathogen coevolution and relaxed selection for expression of uninduced defense genes are viable interpretations of these data. ..
  11. de Oliveira C, Manfrin M, Sene F, Jackson L, Etges W. Variations on a theme: diversification of cuticular hydrocarbons in a clade of cactophilic Drosophila. BMC Evol Biol. 2011;11:179 pubmed publisher
  12. Dean J, Moravec M, Grafe M, Abend N, Ren J, Gong X, et al. Strain-specific differences in perinatal rodent oligodendrocyte lineage progression and its correlation with human. Dev Neurosci. 2011;33:251-60 pubmed publisher
    ..Later developmental onset of preOL maturation in both cerebral cortex and hippocampus coincides with an extended window of potential vulnerability of the OL lineage to hypoxia-ischemia in these gray matter regions. ..
  13. Castillo D, Mell J, Box K, Blumenstiel J. Molecular evolution under increasing transposable element burden in Drosophila: a speed limit on the evolutionary arms race. BMC Evol Biol. 2011;11:258 pubmed publisher
    ..Third, we test whether increasing TE abundance is correlated with greater codon bias in genes of the piRNA machinery. This is predicted if increasing TE abundance selects for increased efficiency in the machinery of genome defense...
  14. Cruickshank T, Wade M. Maternal adjustment of the sex ratio in broods of the broad-horned flour beetle, Gnathocerus cornutus. Integr Comp Biol. 2012;52:100-7 pubmed publisher
  15. Hunter E, Gibbs J, Cayot L, Tapia W. Equivalency of Galápagos giant tortoises used as ecological replacement species to restore ecosystem functions. Conserv Biol. 2013;27:701-9 pubmed publisher
    ..Our results also demonstrate the value of trial introductions of sterilized individuals to test niche equivalency among candidate analog species. ..
  16. Pienaar E, Lew D, Wallmo K. The importance of survey content: testing for the context dependency of the New Ecological Paradigm Scale. Soc Sci Res. 2015;51:338-49 pubmed publisher
    ..Given the wide, multi-disciplinary use of the NEP Scale, it is important for researchers to recognize that NEP-based measures of environmental concern may be sensitive to information included in surveys. ..
  17. Soper Gorden N, Winkler K, Jahnke M, Marshall E, Horky J, Huddelson C, et al. Geographic patterns of seed mass are associated with climate factors, but relationships vary between species. Am J Bot. 2016;103:60-72 pubmed publisher
    ..Overall, this study suggests that the scale of climate variation that molds seed traits is highly species-specific. ..
  18. Declerck M, Bailey Y, Craig D, Lin M, Auerbach L, Linney O, et al. Efficacy of Topical Treatments for Chrysaora chinensis Species: A Human Model in Comparison with an In Vitro Model. Wilderness Environ Med. 2016;27:25-38 pubmed publisher
    ..Despite this study's limitations, it presents a viable basis for future human studies looking at the efficacy of topical treatments for jellyfish stings. ..
  19. Takahara K, Bong M, Brevard R, Eddy R, Haley L, Sait S, et al. Mouse and human homologues of the yeast origin of replication recognition complex subunit ORC2 and chromosomal localization of the cognate human gene ORC2L. Genomics. 1996;31:119-22 pubmed
    ..Analyses of somatic cell hybrid DNA and fluorescence in situ hybridization were employed to map the human ORC2L gene to chromosome 2q33. ..
  20. Risinger F. Genetic analyses of ethanol-induced hyperglycemia. Alcohol Clin Exp Res. 2003;27:756-64 pubmed
    ..These findings indicate important sex differences in the glycemic response to ethanol. In addition, multiple genes likely control this response, independent from genes that are important for the thermic or aversive effects of ethanol. ..
  21. Gorin Meyer R, Wiren K, Tanchuck M, Long S, Yoneyama N, Finn D. Sex differences in the effect of finasteride on acute ethanol withdrawal severity in C57BL/6J and DBA/2J mice. Neuroscience. 2007;146:1302-15 pubmed
    ..Sex differences in the modulation of GABAergic 5alpha-reduced steroids may be an important consideration in understanding and developing therapeutic interventions in alcoholics. ..
  22. Wisely S, Howard J, Williams S, Bain O, Santymire R, Bardsley K, et al. An unidentified filarial species and its impact on fitness in wild populations of the black-footed ferret (Mustela nigripes). J Wildl Dis. 2008;44:53-64 pubmed
    ..Nonetheless, this previously undescribed filaria does not appear to threaten recovery for this highly endangered mammal. ..
  23. Pomper K, Lowe J, Crabtree S, Keller W. Identification of annonaceous acetogenins in the ripe fruit of the North American pawpaw ( Asimina triloba ). J Agric Food Chem. 2009;57:8339-43 pubmed publisher
    ..An assessment of the potential human health risk of overconsumption of fruit and acetogenin bioavailability and degradation studies should be pursued. ..
  24. Ahn S, Kearbey J, Li C, Duke C, Miller D, Dalton J. Biotransformation of a novel antimitotic agent, I-387, by mouse, rat, dog, monkey, and human liver microsomes and in vivo pharmacokinetics in mice. Drug Metab Dispos. 2011;39:636-43 pubmed publisher
    ..The results of these drug metabolism and pharmacokinetic studies provide the foundation for future structural modification of this pharmacophore to improve stability of drugs with potent anticancer effects in cancer patients. ..
  25. Chittiprol S, Chen P, Petrovic Djergovic D, Eichler T, Ransom R. Marker expression, behaviors, and responses vary in different lines of conditionally immortalized cultured podocytes. Am J Physiol Renal Physiol. 2011;301:F660-71 pubmed publisher
    ..These findings demonstrate dramatic differences in marker expression, response to toxins, and motility between lines of podocytes from different species and even between similarly-derived mouse lines. ..
  26. Bachlava E, Taylor C, Tang S, Bowers J, Mandel J, Burke J, et al. SNP discovery and development of a high-density genotyping array for sunflower. PLoS ONE. 2012;7:e29814 pubmed publisher
  27. Del Toro I. Diversity of Eastern North American ant communities along environmental gradients. PLoS ONE. 2013;8:e67973 pubmed publisher
    ..This study contributes to the understanding of mechanisms that structure the communities of important terrestrial arthropods which are likely to be influenced by climatic change. ..
  28. Watters G. A revision of the Annulariidae of Central America (Gastropoda: Littorinoidea). Zootaxa. 2014;3878:301-50 pubmed publisher
    ..Many species are highly endemic. Although not speciose, Central America has a high diversity of conchological forms and may represent the ancestral source of annulariids in general. ..
  29. Wong M, Roper S. Genetic animal models of malformations of cortical development and epilepsy. J Neurosci Methods. 2016;260:73-82 pubmed publisher
  30. Haney J, Phillips T, Sielken R, Valdez Flores C. Development of an inhalation unit risk factor for isoprene. Regul Toxicol Pharmacol. 2015;73:712-25 pubmed publisher
    ..The mean for ambient air monitoring sites in Texas (2005-2014) is approximately 0.13 ppb. ..
  31. Fautsch M, Vrabel A, Rickard D, Subramaniam M, Spelsberg T, Wieben E. Characterization of the mouse TGFbeta-inducible early gene (TIEG): conservation of exon and transcriptional regulatory sequences with evidence of additional transcripts. Mamm Genome. 1998;9:838-42 pubmed
  32. Stewart P, Chapes S. Role of major histocompatibility complex class II in resistance of mice to naturally acquired infection with Syphacia obvelata. Comp Med. 2003;53:70-4 pubmed
    ..obvelata. These data justify further comprehensive analyses of the immune components that are involved in pinworm resistance. ..
  33. Crossgrove J, Yokel R. Manganese distribution across the blood-brain barrier III. The divalent metal transporter-1 is not the major mechanism mediating brain manganese uptake. Neurotoxicology. 2004;25:451-60 pubmed
    ..Mn appears to distribute across the rat blood-brain barrier (BBB) into the brain by one or more carrier-mediated processes other than the DMT-1. ..
  34. Bonner C, Jensen R, Gander J, Keyhani N. A core catalytic domain of the TyrA protein family: arogenate dehydrogenase from Synechocystis. Biochem J. 2004;382:279-91 pubmed
    ..Comparative enzymology established that both of the arogenate-pathway enzymes, prephenate aminotransferase and TyrA(a), were present in many diverse cyanobacteria and in a variety of eukaryotic red and green algae. ..
  35. Gitiban N, Jurcisek J, Harris R, Mertz S, Durbin R, Bakaletz L, et al. Chinchilla and murine models of upper respiratory tract infections with respiratory syncytial virus. J Virol. 2005;79:6035-42 pubmed
    ..Ultimately, we hope to investigate the relative ability of these candidates to potentially protect against viral predisposal to bacterial OM...
  36. Giurumescu C, Sternberg P, Asthagiri A. Predicting phenotypic diversity and the underlying quantitative molecular transitions. PLoS Comput Biol. 2009;5:e1000354 pubmed publisher
  37. Ospina Giraldo M, Griffith J, Laird E, Mingora C. The CAZyome of Phytophthora spp.: a comprehensive analysis of the gene complement coding for carbohydrate-active enzymes in species of the genus Phytophthora. BMC Genomics. 2010;11:525 pubmed publisher
    ..infestans, P. sojae, and P. ramorum, a significant number of which could play roles critical for pathogenicity, by participating in the degradation of the plant cell wall. ..
  38. Bi E, Dai K, Subbarao S, Beall B, Lutkenhaus J. FtsZ and cell division. Res Microbiol. 1991;142:249-52 pubmed
    ..Analysis of the ftsZ gene from Bacillus subtilis revealed that the gene was required for both septation during vegetative growth and asymmetric septation during sporulation. ..
  39. Thakur A, Landolfi N. A potent neutralizing monoclonal antibody can discriminate amongst IFNgamma from various primates with greater specificity than can the human IFNgamma receptor complex. Mol Immunol. 1999;36:1107-15 pubmed
    ..Therefore, this neutralizing monoclonal antibody reacts with a conformational determinant that distinguishes primate IFNgammas serologically, but not functionally. ..
  40. Hubbard L, McSteen P, Doebley J, Hake S. Expression patterns and mutant phenotype of teosinte branched1 correlate with growth suppression in maize and teosinte. Genetics. 2002;162:1927-35 pubmed
    ..Expression in teosinte inflorescence development suggests a role in pedicellate spikelet suppression. Our results provide support for a role for tb1 in growth suppression and reveal the specific tissues where suppression may occur. ..
  41. Kroumova A, Wagner G. Different elongation pathways in the biosynthesis of acyl groups of trichome exudate sugar esters from various solanaceous plants. Planta. 2003;216:1013-21 pubmed
    ..Results are consistent with participation of alphaKAE in synthesis of sugar-ester acyl groups of tobaccos and petunia, but apparently FAS is utilized in the formation of these groups in L. pennellii and D. metel. ..
  42. Cao Z, Tanguay R, McKenzie D, Peterson R, Aiken J. Identification of a putative calcium-binding protein as a dioxin-responsive gene in zebrafish and rainbow trout. Aquat Toxicol. 2003;63:271-82 pubmed
    ..However, demonstration that the encoded S100A4 proteins actually bind calcium and play a role in dioxin toxicity will require further study. ..
  43. Samerotte A, Drazen J, Brand G, Seibel B, Yancey P. Correlation of trimethylamine oxide and habitat depth within and among species of teleost fish: an analysis of causation. Physiol Biochem Zool. 2007;80:197-208 pubmed
    ..Overall, the data strongly support the hypothesis that TMAO is adaptively regulated with depth in deep-sea teleosts. Whether lipid metabolism is the source of that TMAO is a question that remains to be tested fully. ..
  44. Khaladkar M, Liu J, Wen D, Wang J, Tian B. Mining small RNA structure elements in untranslated regions of human and mouse mRNAs using structure-based alignment. BMC Genomics. 2008;9:189 pubmed publisher
    ..Our result indicates that there may exist many conserved stem-loop structures in mammalian UTRs that are involved in coordinate post-transcriptional regulation of biological pathways. ..
  45. Flores G, Liu Y, Ferrera I, Beveridge T, Reysenbach A. Sulfurihydrogenibium kristjanssonii sp. nov., a hydrogen- and sulfur-oxidizing thermophile isolated from a terrestrial Icelandic hot spring. Int J Syst Evol Microbiol. 2008;58:1153-8 pubmed publisher
    ..nov. is proposed. The type strain is I6628T (=DSM 19534T =OCM 901T =ATCC BAA-1535T). ..
  46. Lu Y, Parker M, Pileggi A, Zhang B, Choi Y, Molano R, et al. Human alpha 1-antitrypsin therapy induces fatal anaphylaxis in non-obese diabetic mice. Clin Exp Immunol. 2008;154:15-21 pubmed publisher
    ..The susceptibility of NOD mice to hypersensitivity provides a significant limitation for testing of hAAT. Development of strategies to avoid this unwanted response is required to use this promising therapeutic agent for T1D. ..
  47. Lee D, Lee J, Sugden B. The unfolded protein response and autophagy: herpesviruses rule!. J Virol. 2009;83:1168-72 pubmed publisher
  48. Glasner J, Marquez Villavicencio M, Kim H, Jahn C, Ma B, Biehl B, et al. Niche-specificity and the variable fraction of the Pectobacterium pan-genome. Mol Plant Microbe Interact. 2008;21:1549-60 pubmed publisher
  49. Janowski E, Day R, Kraev A, Roder J, Cleemann L, Morad M. beta-adrenergic regulation of a novel isoform of NCX: sequence and expression of shark heart NCX in human kidney cells. Am J Physiol Heart Circ Physiol. 2009;296:H1994-2006 pubmed publisher
    ..We conclude that bimodal beta-adrenergic regulation is retained in cloned shark NCX and is dependent on the shark's unique molecular motifs...
  50. Bisson I, Safi K, Holland R. Evidence for repeated independent evolution of migration in the largest family of bats. PLoS ONE. 2009;4:e7504 pubmed publisher
    ..Our study provides a strong framework for future research on the evolution of migration in chiropterans. ..
  51. Tarsa L, Bałkowiec Iskra E, Kratochvil F, Jenkins V, McLean A, Brown A, et al. Tooth pulp inflammation increases brain-derived neurotrophic factor expression in rodent trigeminal ganglion neurons. Neuroscience. 2010;167:1205-15 pubmed publisher
    ..Overall, the inflammation-induced upregulation of BDNF is stronger in mice compared to rats. Thus, mouse TG provides a suitable model to study molecular mechanisms of inflammation-dependent regulation of BDNF expression in vivo. ..
  52. Kozak G, Head M, Boughman J. Sexual imprinting on ecologically divergent traits leads to sexual isolation in sticklebacks. Proc Biol Sci. 2011;278:2604-10 pubmed publisher
  53. Ewel J, Bigelow S. Tree species identity and interactions with neighbors determine nutrient leaching in model tropical forests. Oecologia. 2011;167:1127-40 pubmed publisher
    ..Even unrealistically simple multi-life-form mimics of tropical forest can safeguard a site's nutrient capital if careful attention is paid to species' characteristics and temporal changes in interspecific interactions...
  54. Dinh T, Girke T, Liu X, Yant L, Schmid M, Chen X. The floral homeotic protein APETALA2 recognizes and acts through an AT-rich sequence element. Development. 2012;139:1978-86 pubmed publisher
    ..It also sets the foundation for understanding the basis of the broad biological functions of AP2 in Arabidopsis, as well as the divergent biological functions of AP2 orthologs in dicotyledonous plants. ..
  55. Williams R, Segovia Hinostroza K, Ghersi B, Gonzaga V, Peterson A, Montgomery J. Avian Influenza infections in nonmigrant land birds in Andean Peru. J Wildl Dis. 2012;48:910-7 pubmed publisher
    ..Surveillance programs for monitoring spread and identification of AIV should thus not focus solely on water birds. ..
  56. Blech Hermoni Y, Stillwagon S, Ladd A. Diversity and conservation of CELF1 and CELF2 RNA and protein expression patterns during embryonic development. Dev Dyn. 2013;242:767-77 pubmed publisher
    ..CELF1 and CELF2 may underlie conserved, developmentally regulated, tissue-specific processes in vertebrate embryos. Different tissues likely have unique profiles of nuclear and cytoplasmic CELF1- and CELF2-mediated functions...
  57. Oakley B, Morales C, Line J, Berrang M, Meinersmann R, Tillman G, et al. The poultry-associated microbiome: network analysis and farm-to-fork characterizations. PLoS ONE. 2013;8:e57190 pubmed publisher
  58. Huang Y, Li Y, Burt D, Chen H, Zhang Y, Qian W, et al. The duck genome and transcriptome provide insight into an avian influenza virus reservoir species. Nat Genet. 2013;45:776-783 pubmed publisher
    ..These analyses, in combination with the genomic and transcriptomic data, provide a resource for characterizing the interaction between host and influenza viruses. ..
  59. Wangkanont K, Winton V, Forest K, Kiessling L. Conformational Control of UDP-Galactopyranose Mutase Inhibition. Biochemistry. 2017;56:3983-3992 pubmed publisher
    ..This model and the structures suggest strategies for optimizing inhibitor potency by exploiting UGM conformational flexibility. ..
  60. Spritz R, Strunk K, Surowy C, Mohrenweiser H. Human U1-70K ribonucleoprotein antigen gene: organization, nucleotide sequence, and mapping to locus 19q13.3. Genomics. 1990;8:371-9 pubmed
    ..This extraordinary conservation at the nucleotide sequence level suggests that alternative splicing of this exon serves an important function, perhaps in regulating the production of functional U1-70K protein. ..
  61. Verma A, Filoteo A, Stanford D, Wieben E, Penniston J, Strehler E, et al. Complete primary structure of a human plasma membrane Ca2+ pump. J Biol Chem. 1988;263:14152-9 pubmed
  62. Keller S, Scott H, Mastick C, Aebersold R, Lienhard G. Cloning and characterization of a novel insulin-regulated membrane aminopeptidase from Glut4 vesicles. J Biol Chem. 1995;270:23612-8 pubmed
  63. Felix M, Sternberg P. A gonad-derived survival signal for vulval precursor cells in two nematode species. Curr Biol. 1998;8:287-90 pubmed
    ..Our results demonstrate the existence of intercellular cell-survival signals in nematodes and uncover an evolutionary variation in the role of the gonad in nematode vulval development. ..
  64. Gaucher E, Miyamoto M, Benner S. Function-structure analysis of proteins using covarion-based evolutionary approaches: Elongation factors. Proc Natl Acad Sci U S A. 2001;98:548-52 pubmed
    ..We illustrate this in the elongation factor family of proteins as a paradigm for applications of this type of analysis in functional genomics generally. ..
  65. Doelling J, Yan N, Kurepa J, Walker J, Vierstra R. The ubiquitin-specific protease UBP14 is essential for early embryo development in Arabidopsis thaliana. Plant J. 2001;27:393-405 pubmed
    ..Taken together, the data demonstrate an essential role for the ubiquitin/26S proteasome pathway in general and for AtUBP14 in particular during early plant development. ..
  66. Lindemann C. Structural-functional relationships of the dynein, spokes, and central-pair projections predicted from an analysis of the forces acting within a flagellum. Biophys J. 2003;84:4115-26 pubmed
    ..However, to fulfill this role without preventing flagellar bend formation, moveable attachments that behave like processive motor proteins must mediate the attachment between the spoke heads and the central-pair structure. ..
  67. Baker P, Leff L. Intraspecific differences in bacterial responses to modelled reduced gravity. J Appl Microbiol. 2005;98:1239-46 pubmed
    ..Efforts to remove microbial contaminants are likely to be complicated by the features of these bacteria which allow them to persist under the extreme conditions of the systems. ..
  68. Hiett K, Stern N, Fedorka Cray P, Cox N, Seal B. Molecular phylogeny of the flaA short variable region among Campylobacter jejuni isolates collected during an annual evaluation of poultry flocks in the Southeastern United States. Foodborne Pathog Dis. 2007;4:339-47 pubmed
    ..and that these subtypes can contribute to contamination of the final commercial product. ..
  69. Aevermann B, Waters E. A comparative genomic analysis of the small heat shock proteins in Caenorhabditis elegans and briggsae. Genetica. 2008;133:307-19 pubmed
    ..elegans and C. briggsae sHSPs. However, the evolutionary patterns do suggest that functional divergence has occurred between the sHSPs in C. elegans and C. briggsae and the sHSPs in more distantly related invertebrates. ..
  70. Sherwood T, Askwith C. Endogenous arginine-phenylalanine-amide-related peptides alter steady-state desensitization of ASIC1a. J Biol Chem. 2008;283:1818-30 pubmed
    ..Furthermore, our finding that endogenous peptides shift steady-state desensitization suggests that RF-amides could impact the role of ASIC1a in both pain and neuronal damage following stroke and ischemia. ..
  71. Desai Shah M, Cooper R. Different mechanisms of Ca2+ regulation that influence synaptic transmission: comparison between crayfish and Drosophila neuromuscular junctions. Synapse. 2009;63:1100-21 pubmed publisher
    ..Results in crayfish NMJ were more consistent with expected results as compared to the Drosophila NMJ. It is predicated that different mechanisms are used for regulating the [Ca(2+)](i) in high and low output synaptic terminals. ..
  72. Estrada C, Yildizhan S, Schulz S, Gilbert L. Sex-specific chemical cues from immatures facilitate the evolution of mate guarding in Heliconius butterflies. Proc Biol Sci. 2010;277:407-13 pubmed publisher
    ..Their maintenance, despite lack of female mate choice, may be explained by variation in cost that females pay with this male behaviour under heterogeneous ecological conditions. ..
  73. Goodson J, Thompson R. Nonapeptide mechanisms of social cognition, behavior and species-specific social systems. Curr Opin Neurobiol. 2010;20:784-94 pubmed publisher
  74. Ip H, Dusek R, Heisey D. The effect of swab sample choice on the detection of avian influenza in apparently healthy wild ducks. Avian Dis. 2012;56:114-9 pubmed
    ..When considering recent studies showing that HPAI H5N1 can be better detected in the respiratory tract, the FCS is the most appropriate sample to collect for HPAI H5N1 surveillance while not compromising LPAI studies. ..
  75. Guo Y, Feng P. OX2R activation induces PKC-mediated ERK and CREB phosphorylation. Exp Cell Res. 2012;318:2004-13 pubmed publisher
    ..And hypothalamus neuron cells may use different downsteam pathway for orexin B induced ERK phosphorylation. This result supports findings that orexins might have anti-depressive roles. ..
  76. Scholl B, Tan A, COREY J, Priebe N. Emergence of orientation selectivity in the Mammalian visual pathway. J Neurosci. 2013;33:10616-24 pubmed publisher
  77. LaLone C, Villeneuve D, Cavallin J, Kahl M, Durhan E, Makynen E, et al. Cross-species sensitivity to a novel androgen receptor agonist of potential environmental concern, spironolactone. Environ Toxicol Chem. 2013;32:2528-41 pubmed publisher
  78. Smith R, Maguire M. Distribution of the CorA Mg2+ transport system in gram-negative bacteria. J Bacteriol. 1995;177:1638-40 pubmed
    ..Virtually all strains tested positive for the presence of corA. Thus, corA appears to be ubiquitous within gram-negative bacteria and is likely their major Mg2+ influx system. ..
  79. N lling J, Reeve J. Growth- and substrate-dependent transcription of the formate dehydrogenase (fdhCAB) operon in Methanobacterium thermoformicicum Z-245. J Bacteriol. 1997;179:899-908 pubmed
    ..Sequencing revealed the presence of very similar genes except that the genome of M. thermoautotrophicum, a methanogen incapable of growth on formate, lacked the fdhCAB operon...
  80. Ramamurthy V, Oliver D. Topology of the integral membrane form of Escherichia coli SecA protein reveals multiple periplasmically exposed regions and modulation by ATP binding. J Biol Chem. 1997;272:23239-46 pubmed
    ..The importance of these studies to the cycle of membrane insertion and de-insertion of SecA that promotes protein translocation and SecA's proximity to the preprotein channel are discussed...
  81. Farmer S, Powell S, Wilkins D, Graham A. Cloning, sequencing and functional expression of a guinea pig lung bradykinin B2 receptor. Eur J Pharmacol. 1998;346:291-8 pubmed
    ..Curiously, several B1 and B2 receptor antagonists induced 45Ca2+ efflux, indicating that this receptor may be coupled differently in CHO cells than in native tissues. ..
  82. Nilsson W, Strom M. Detection and identification of bacterial pathogens of fish in kidney tissue using terminal restriction fragment length polymorphism (T-RFLP) analysis of 16S rRNA genes. Dis Aquat Organ. 2002;48:175-85 pubmed
    ..A similar detection limit was observed for several other gram-negative pathogens. This procedure was also used to detect Aeromonas salmonicida and Renibacterium salmoninarum in the kidney tissue of 2 naturally infected salmonids. ..
  83. Huang J, Price R. Estimation of the age of extant Ephedra using chloroplast rbcL sequence data. Mol Biol Evol. 2003;20:435-40 pubmed
    ..Our result is consistent with the current distribution of many Ephedra species in geologically recent habitats and points out difficulties in the identification of older ephedroid pollen fossils with the modern genus Ephedra...
  84. Conway de Macario E, Macario A. Molecular biology of stress genes in methanogens: potential for bioreactor technology. Adv Biochem Eng Biotechnol. 2003;81:95-150 pubmed
    ..This promising biotechnological development will soon become a reality due to the advances in the study of the stress response and anti-stress mechanisms at the molecular and genetic levels...
  85. Zückert W, Lloyd J, Stewart P, Rosa P, Barbour A. Cross-species surface display of functional spirochetal lipoproteins by recombinant Borrelia burgdorferi. Infect Immun. 2004;72:1463-9 pubmed
    ..They also validate the use of recombinant B. burgdorferi in studies of surface lipoprotein structure-function and the biogenesis of spirochete membranes. ..
  86. Wilcox T, García de León F, Hendrickson D, Hillis D. Convergence among cave catfishes: long-branch attraction and a Bayesian relative rates test. Mol Phylogenet Evol. 2004;31:1101-13 pubmed
    ..Similarly, the sequence data do not support several other relationships within Ictaluridae supported by morphology. We develop a new Bayesian method for examining variation in molecular rates of evolution across a phylogeny...
  87. Fraser J, Davis B, Skjolaas K, Burkey T, Dritz S, Johnson B, et al. Effects of feeding Salmonella enterica serovar Typhimurium or serovar Choleraesuis on growth performance and circulating insulin-like growth factor-I, tumor necrosis factor-alpha, and interleukin-1beta in weaned pigs. J Anim Sci. 2007;85:1161-7 pubmed
    ..We conclude that repeated exposure of weaned pigs to Choleraesuis reduced growth performance in the absence of changes in systemic inflammatory cytokines. ..
  88. Kothary M, McCardell B, Frazar C, Deer D, Tall B. Characterization of the zinc-containing metalloprotease encoded by zpx and development of a species-specific detection method for Enterobacter sakazakii. Appl Environ Microbiol. 2007;73:4142-51 pubmed publisher
    ..23. The sequence possesses three well-characterized zinc-binding and active-site motifs present in other bacterial zinc metalloproteases...
  89. Ding K, McDonough S, Kullo I. Evidence for positive selection in the C-terminal domain of the cholesterol metabolism gene PCSK9 based on phylogenetic analysis in 14 primate species. PLoS ONE. 2007;2:e1098 pubmed
    ..These results suggest that among primates, differential selective pressure has shaped evolutionary patterns in the functional domains of PCSK9, an important regulator of cholesterol homeostasis. ..
  90. Cappon G, Bush B, Newgreen D, Finch G, Alper R. Tolterodine does not affect memory assessed by passive-avoidance response test in mice. Eur J Pharmacol. 2008;579:225-8 pubmed
    ..Therefore, at a dose exceeding therapeutic exposure by six-fold, tolterodine had no effect on memory in the mouse passive-avoidance model, indicating that tolterodine does not disrupt cognitive function in this testing paradigm. ..
  91. Sutherland J, Page M, Conti L. The effect of corticotropin-releasing factor on prepulse inhibition is independent of serotonin in Brown Norway and Wistar-Kyoto rats. Pharmacol Biochem Behav. 2008;89:324-37 pubmed publisher
    ..3 microg or 3.0 microg). CRF decreased PPI despite 5-HT depletion. These findings suggest that CRF does not decrease PPI via effects on 5-HT, since neither blockade of 5-HT(2A/C) receptors nor 5-HT depletion attenuated this decrease. ..
  92. Jeong S, Rebeiz M, Andolfatto P, Werner T, True J, Carroll S. The evolution of gene regulation underlies a morphological difference between two Drosophila sister species. Cell. 2008;132:783-93 pubmed publisher
    ..We submit that there is sufficient empirical evidence to support the general prediction that functional evolutionary changes at pleiotropic loci will most often involve mutations in their discrete, modular cis-regulatory elements...