Genomes and Genes
Experts and Doctors on species specificity in United Kingdom
Locale: United Kingdom
Topic: species specificity
Publications201 found, 100 shown here
- Loppin B, Lepetit D, Dorus S, Couble P, Karr T. Origin and neofunctionalization of a Drosophila paternal effect gene essential for zygote viability. Curr Biol. 2005;15:87-93 pubmed publisher..We present a detailed case history of the origin and evolution of a new essential gene and, in so doing, provide the first molecular identification of a Drosophila paternal effect gene, ms(3)K81 (K81)...
- Seddon N. Ecological adaptation and species recognition drives vocal evolution in neotropical suboscine birds. Evolution. 2005;59:200-15 pubmed..To my knowledge, these data provide the first direct evidence that species recognition and ecological adaptation operate in tandem, and that the interplay between these factors drives the evolution of mating signals in suboscine birds. ..
- Waldron D, Lindsay J. Sau1: a novel lineage-specific type I restriction-modification system that blocks horizontal gene transfer into Staphylococcus aureus and between S. aureus isolates of different lineages. J Bacteriol. 2006;188:5578-85 pubmed..aureus isolates from other species, as well as for controlling the spread of resistance genes between isolates of different S. aureus lineages. Blocking Sau1 should also allow genetic manipulation of clinical strains of S. aureus. ..
- Jones P, Chase K, Martin A, Davern P, Ostrander E, Lark K. Single-nucleotide-polymorphism-based association mapping of dog stereotypes. Genetics. 2008;179:1033-44 pubmed publisher..The strengths and limitations of the approach are discussed as well as its potential to identify loci regulating the within-breed incidence of specific polygenic diseases. ..
- Finch A, Caunt C, Armstrong S, McArdle C. Plasma membrane expression of gonadotropin-releasing hormone receptors: regulation by peptide and nonpeptide antagonists. Mol Endocrinol. 2010;24:423-35 pubmed publisher..This distinction between peptide and nonpeptide antagonists may prove important for therapeutic applications of GnRH antagonists. ..
- Haddrill P, Loewe L, Charlesworth B. Estimating the parameters of selection on nonsynonymous mutations in Drosophila pseudoobscura and D. miranda. Genetics. 2010;185:1381-96 pubmed publisher..Overall, the results show that both purifying selection and positive selection on nonsynonymous mutations are pervasive. ..
- Eriksson B, Stollewerk A. Expression patterns of neural genes in Euperipatoides kanangrensis suggest divergent evolution of onychophoran and euarthropod neurogenesis. Proc Natl Acad Sci U S A. 2010;107:22576-81 pubmed publisher..Based on these data and additional evidence, we suggest an evolutionary sequence of arthropod neurogenesis that is in line with the Mandibulata hypothesis. ..
- Vallejo Marin M, Solís Montero L, Bacles C, Lepais O. Thirteen microsatellites developed by SSR-enriched pyrosequencing for Solanum rostratum (Solanaceae) and related species. Am J Bot. 2011;98:e296-9 pubmed publisher..Microsatellite markers were developed using second-generation sequencing in Solanum rostratum as a tool to study the reproductive biology and genetic structure of this invasive species...
- Beeton M, Atkinson D, Waterfield N. An amoeba phagocytosis model reveals a novel developmental switch in the insect pathogen Bacillus thuringiensis. J Insect Physiol. 2013;59:223-31 pubmed publisher..We suggest these developmental fates are likely to be important both in the ecology of these bacteria and also during animal host colonisation and immune evasion...
- Palgrave C, Gilmour L, Lowden C, Lillico S, Mellencamp M, Whitelaw C. Species-specific variation in RELA underlies differences in NF-?B activity: a potential role in African swine fever pathogenesis. J Virol. 2011;85:6008-14 pubmed publisher..We propose that the variation in RELA identified between the warthog and domestic pig has the potential to underlie the difference between tolerance and rapid death upon ASFV infection...
- O Shaughnessy P, Gray S. Gonadotropin-dependent and gonadotropin-independent development of inhibin subunit messenger ribonucleic acid levels in the mouse ovary. Endocrinology. 1995;136:2060-5 pubmed..The inhibin alpha-subunit, in contrast, is expressed at a high level during development independent of gonadotropin stimulation. ..
- Filatov D, Charlesworth D. DNA polymorphism, haplotype structure and balancing selection in the Leavenworthia PgiC locus. Genetics. 1999;153:1423-34 pubmed..The age of the haplotypes and the results of Kelly's Z(nS) and Wall's B and Q tests with recombination suggest that the haplotypes are maintained due to balancing selection at or near this locus. ..
- Dockrell H, Brahmbhatt S, Robertson B, Britton S, Fruth U, Gebre N, et al. A postgenomic approach to identification of Mycobacterium leprae-specific peptides as T-cell reagents. Infect Immun. 2000;68:5846-55 pubmed..A pool of such peptides, formulated as a skin test reagent, could be used to monitor exposure to leprosy or as an aid to early diagnosis...
- Urban S, Freeman M. Substrate specificity of rhomboid intramembrane proteases is governed by helix-breaking residues in the substrate transmembrane domain. Mol Cell. 2003;11:1425-34 pubmed..These results provide an explanation of how rhomboid proteases achieve specificity, and allow some rhomboid substrates to be predicted from sequence information. ..
- Humphries S, Lu Y, Canty E, Kadler K. Active negative control of collagen fibrillogenesis in vivo. Intracellular cleavage of the type I procollagen propeptides in tendon fibroblasts without intracellular fibrils. J Biol Chem. 2008;283:12129-35 pubmed publisher..Furthermore, the results show that murine postnatal tendon cells have a high capacity to prevent intracellular collagen fibrillogenesis. ..
- Soanes D, Alam I, Cornell M, Wong H, Hedeler C, Paton N, et al. Comparative genome analysis of filamentous fungi reveals gene family expansions associated with fungal pathogenesis. PLoS ONE. 2008;3:e2300 pubmed publisher..The results demonstrate the potential of comparative genome analysis for exploring the evolution of eukaryotic microbial pathogenesis. ..
- Grime J, Fridley J, Askew A, Thompson K, Hodgson J, Bennett C. Long-term resistance to simulated climate change in an infertile grassland. Proc Natl Acad Sci U S A. 2008;105:10028-32 pubmed publisher..Our results support the view that changing land use and overexploitation rather than climate change per se constitute the primary threats to these fragile ecosystems. ..
- Johansen Berg H, Rushworth M. Using diffusion imaging to study human connectional anatomy. Annu Rev Neurosci. 2009;32:75-94 pubmed publisher..We conclude that although tractography offers novel opportunities it also raises significant challenges to be addressed by further validation studies to define precisely the limitations and scope of this exciting new technique. ..
- Vordermeier H, Dean G, Rosenkrands I, Agger E, Andersen P, Kaveh D, et al. Adjuvants induce distinct immunological phenotypes in a bovine tuberculosis vaccine model. Clin Vaccine Immunol. 2009;16:1443-8 pubmed publisher..These results demonstrate the importance of testing adjuvant formulations directly in the target species and the necessity of measuring different types of immune response when evaluating immune responses. ..
- Harries L, Brown J, Gloyn A. Species-specific differences in the expression of the HNF1A, HNF1B and HNF4A genes. PLoS ONE. 2009;4:e7855 pubmed publisher..We conclude that alterations to expression of HNF isoforms may underlie some of the phenotypic variation caused by mutations in these genes. ..
- He M, Sebaihia M, Lawley T, Stabler R, Dawson L, Martin M, et al. Evolutionary dynamics of Clostridium difficile over short and long time scales. Proc Natl Acad Sci U S A. 2010;107:7527-32 pubmed publisher..1-85 million years. By contrast, the disease-causing isolates have arisen from multiple lineages, suggesting that virulence evolved independently in the highly epidemic lineages. ..
- Peiso O, Bronsvoort B, Handel I, Volkova V. A review of exotic animal disease in Great Britain and in Scotland specifically between 1938 and 2007. PLoS ONE. 2011;6:e22066 pubmed publisher..Over the 70 years, the diseases were reported with lower frequency and lower annual incidence in Scotland, as compared to when these statistics are considered for GB as a whole. ..
- Teles C, Smith A, Lang S. Antibiotic modulation of the plasminogen binding ability of viridans group streptococci. Antimicrob Agents Chemother. 2012;56:458-63 pubmed publisher..It remains difficult to accurately predict isolate responses to sub-MIC antimicrobials since there appears to be interspecies variation. ..
- Koprivova A, Giovannetti M, Baraniecka P, Lee B, Grondin C, Loudet O, et al. Natural variation in the ATPS1 isoform of ATP sulfurylase contributes to the control of sulfate levels in Arabidopsis. Plant Physiol. 2013;163:1133-41 pubmed publisher..Thus, sulfate content in Arabidopsis is controlled by two genes encoding subsequent enzymes in the sulfate assimilation pathway but using different mechanisms, variation in amino acid sequence and variation in expression levels. ..
- Harris D, Matías L, Thomas L, Harwood J, Geissler W. Applying distance sampling to fin whale calls recorded by single seismic instruments in the northeast Atlantic. J Acoust Soc Am. 2013;134:3522-35 pubmed publisher..e., vocalization) rate. This study demonstrates the potential for using a sparse array of widely spaced, independently operating acoustic sensors, such as OBSs, for estimating cetacean density. ..
- Pilz A, Moseley H, Peters J, Abbott C. Comparative mapping of mouse chromosome 2 and human chromosome 9q: the genes for gelsolin and dopamine beta-hydroxylase map to mouse chromosome 2. Genomics. 1992;12:715-9 pubmed..The loci for gelsolin and dopamine beta-hydroxylase therefore form part of the conserved synteny between HSA9q and MMU2. ..
- Beechey C, Tweedie S, Spurr N, Ball S, Peters J, Edwards Y. Mapping of mouse carbonic anhydrase-3, Car-3: another locus in the homologous region of mouse chromosome 3 and human chromosome 8. Genomics. 1990;6:692-6 pubmed
- Maguire B, Wild D. Mutations in the rpmBG operon of Escherichia coli that affect ribosome assembly. J Bacteriol. 1997;179:2486-93 pubmed..The results suggest that protein L33, in contrast to protein L28, has at best a minor role in ribosome assembly and function. ..
- Raibaud S, Schwarz Linek U, Kim J, Jenkins H, Baines E, Gurusiddappa S, et al. Borrelia burgdorferi binds fibronectin through a tandem beta-zipper, a common mechanism of fibronectin binding in staphylococci, streptococci, and spirochetes. J Biol Chem. 2005;280:18803-9 pubmed..Thus, these phylogenetically and morphologically distinct bacterial pathogens have similar mechanisms for binding to human fibronectin. ..
- Davidson H, McLachlan G, Wilson A, Boyd A, Doherty A, MacGregor G, et al. Human-specific cystic fibrosis transmembrane conductance regulator antibodies detect in vivo gene transfer to ovine airways. Am J Respir Cell Mol Biol. 2006;35:72-83 pubmed..The strategic use of hCFTR-specific antibodies supports the utility of the normal sheep as a model for hCFTR gene transfer studies. ..
- Baptista I, Zhou N, Emanuelsson E, Peeva L, Leak D, Mantalaris A, et al. Evidence of species succession during chlorobenzene biodegradation. Biotechnol Bioeng. 2008;99:68-74 pubmed..34 h(-1)) and higher substrate affinity (K(s) = 0.35 mg L(-1)) than strain JS150. Finally, this study contributed to the characterisation of the recently established Pandoraea genus, an emerging group in the biodegradation field. ..
- Abuoun M, Suthers P, Jones G, Carter B, Saunders M, Maranas C, et al. Genome scale reconstruction of a Salmonella metabolic model: comparison of similarity and differences with a commensal Escherichia coli strain. J Biol Chem. 2009;284:29480-8 pubmed publisher..These differences provide valuable insight into differences between a commensal and a closely related pathogen and within different pathogenic strains opening new avenues for future explorations. ..
- Lewitus E, Hof P, Sherwood C. Phylogenetic comparison of neuron and glia densities in the primary visual cortex and hippocampus of carnivores and primates. Evolution. 2012;66:2551-63 pubmed publisher..We propose that adaptations to modularity at the cellular level may carry a deep phylogenetic signal. ..
- Crouch K, Smith L, Williams R, Cao W, Lee M, Jensen A, et al. Humoral immune response of the small-spotted catshark, Scyliorhinus canicula. Fish Shellfish Immunol. 2013;34:1158-69 pubmed publisher..Thus, unlike nurse sharks where antigen-specific monomeric IgM and IgNAR appear together, it seems there may be a temporal or complete 'uncoupling' of these isotypes during a humoral response in the small-spotted catshark...
- Graham S, Wartosch L, Gray S, Scourfield E, Deane J, Luzio J, et al. Structural basis of Vps33A recruitment to the human HOPS complex by Vps16. Proc Natl Acad Sci U S A. 2013;110:13345-50 pubmed publisher..The Vps33A-Vps16 complex provides a structural framework for studying the association between Sec1/Munc18 proteins and tethering complexes. ..
- Roberts A, Renwick A. The pharmacokinetics and tissue concentrations of cyclohexylamine in rats and mice. Toxicol Appl Pharmacol. 1989;98:230-42 pubmed..The pharmacokinetics of cyclohexylamine make an important contribution to the difference in sensitivity to testicular atrophy in rats and mice and the dose-response relationship for this toxicity in rats. ..
- Lloyd J, Thomas G, Finlay J, Cole J, Macaskie L. Microbial reduction of technetium by Escherichia coli and Desulfovibrio desulfuricans: enhancement via the use of high-activity strains and effect of process parameters. Biotechnol Bioeng. 1999;66:122-30 pubmed..3 h for the wild-type E. coli, 4.25 h for the upregulated mutant, and 1.5 h for D. desulfuricans. ..
- Emes R, Riley M, Laukaitis C, Goodstadt L, Karn R, Ponting C. Comparative evolutionary genomics of androgen-binding protein genes. Genome Res. 2004;14:1516-29 pubmed..We propose a role for ABPalpha/beta/gamma proteins as pheromones, or in modulating odorant detection. This would account for the extraordinary adaptive evolution of these genes, and surrounding genomic regions, in murid rodents. ..
- Cocheme H, Murphy M. Complex I is the major site of mitochondrial superoxide production by paraquat. J Biol Chem. 2008;283:1786-98 pubmed..Together this membrane potential-dependent uptake across the mitochondrial inner membrane and the subsequent rapid reduction to the paraquat radical cation explain the toxicity of paraquat to mitochondria...
- Tarlinton R, Meers J, Young P. Biology and evolution of the endogenous koala retrovirus. Cell Mol Life Sci. 2008;65:3413-21 pubmed publisher..Part of a multi-author review)...
- Purves D, Lichstein J, Strigul N, Pacala S. Predicting and understanding forest dynamics using a simple tractable model. Proc Natl Acad Sci U S A. 2008;105:17018-22 pubmed publisher..Consistent with this, the PPA predicted that, on these soils, stands are now succeeding to dominance by other late-successional species (e.g., Fraxinus nigra, A. rubrum)...
- Wainford R, Weaver R, Hawksworth G. The immediate early genes, c-fos, c-jun and AP-1, are early markers of platinum analogue toxicity in human proximal tubular cell primary cultures. Toxicol In Vitro. 2009;23:780-8 pubmed publisher..These studies highlight the utility of HPT cultures as an invitro model system, and the potential of c-fos and c-jun as early markers of nephrotoxicity to screen therapeutic lead compounds. ..
- Gong J, Stoeck T, Yi Z, Miao M, Zhang Q, Roberts D, et al. Small subunit rRNA phylogenies show that the class nassophorea is not monophyletic (Phylum Ciliophora). J Eukaryot Microbiol. 2009;56:339-47 pubmed publisher..Expanding the class Phyllopharyngea to include the synhymeniids as a subclass, and designating a new subclass Subkinetalia n. subcl. for the group comprising cyrtophorians, chonotrichians, rhynchodians, and suctorians, are proposed. ..
- Baxter S, Badenes P rez F, Morrison A, Vogel H, Crickmore N, Kain W, et al. Parallel evolution of Bacillus thuringiensis toxin resistance in lepidoptera. Genetics. 2011;189:675-9 pubmed publisher..Here we report genetic mapping of a membrane transporter (ABCC2) to a locus controlling Bt Cry1Ac toxin resistance in two lepidopterans, implying that this protein plays a critical role in Bt function...
- Casali N, Nikolayevskyy V, Balabanova Y, Ignatyeva O, Kontsevaya I, Harris S, et al. Microevolution of extensively drug-resistant tuberculosis in Russia. Genome Res. 2012;22:735-45 pubmed publisher..Polymorphisms conferring fluoroquinolone resistance were independently acquired multiple times within each cluster, indicating that XDR TB is currently not widely transmitted. ..
- Cook J, Otsuki K, Huggins M, Bumstead N. Investigations into resistance of chicken lines to infection with infectious bronchitis virus. Adv Exp Med Biol. 1990;276:491-6 pubmed
- Dufton M, Bladon P, Harvey A. Identification of a locality in snake venom alpha-neurotoxins with a significant compositional similarity to marine snail alpha-conotoxins: implications for evolution and structure/activity. J Mol Evol. 1989;29:355-66 pubmed..Hence, the outcome of this study has important consequences for the current ideas on snake alpha-neurotoxin structure/activity relationships and the evolutionary origins of neurotoxicity. ..
- Hunt D, Cowing J, Patel R, Appukuttan B, Bowmaker J, Mollon J. Sequence and evolution of the blue cone pigment gene in Old and New World primates. Genomics. 1995;27:535-8 pubmed..The silent site divergence between these primate blue genes indicates a separation of the Old and New World primate lineages around 43 million years ago. ..
- Kurtenbach K, Sewell H, Ogden N, Randolph S, Nuttall P. Serum complement sensitivity as a key factor in Lyme disease ecology. Infect Immun. 1998;66:1248-51 pubmed..The species-specific pattern of viability and/or lysis is highly consistent with the pattern of reservoir competence of hosts for B. burgdorferi sensu lato, suggesting a key role of complement in the global ecology of Lyme borreliosis. ..
- Munsey T, Mohindra A, Yusaf S, Grainge A, Wang M, Wray D, et al. Functional properties of Kch, a prokaryotic homologue of eukaryotic potassium channels. Biochem Biophys Res Commun. 2002;297:10-6 pubmed..coli, the cells became critically dependent on K(+) supply for survival. These data are consistent with the proposed function of Kch, i.e., K(+) conduction. ..
- Vordermeier M, Whelan A, Hewinson R. Recognition of mycobacterial epitopes by T cells across mammalian species and use of a program that predicts human HLA-DR binding peptides to predict bovine epitopes. Infect Immun. 2003;71:1980-7 pubmed..bovis-infected cattle. The results obtained in this study support the approach of using bioinformatics to increase the efficiency of epitope screening and selection. ..
- Valverde Garduno V, Guyot B, Anguita E, Hamlett I, Porcher C, Vyas P. Differences in the chromatin structure and cis-element organization of the human and mouse GATA1 loci: implications for cis-element identification. Blood. 2004;104:3106-16 pubmed..These findings suggest that some cis-elements regulating human and mouse GATA1 genes differ. More generally, mouse human sequence comparison may fail to identify all cis-elements. ..
- Martinelli A, Cheesman S, Hunt P, Culleton R, Raza A, Mackinnon M, et al. A genetic approach to the de novo identification of targets of strain-specific immunity in malaria parasites. Proc Natl Acad Sci U S A. 2005;102:814-9 pubmed..Another affected locus, unlinked to this selection valley, contained a member of the serine repeat antigen gene family...
- Nedwell J, Turnpenny A, Lovell J, Edwards B. An investigation into the effects of underwater piling noise on salmonids. J Acoust Soc Am. 2006;120:2550-4 pubmed..Further analysis indicated that this accounted for the relative lack of reaction, and demonstrated the importance of using the correct species of fish as a model when assessing the effect of noise. ..
- Bych K, Netz D, Vigani G, Bill E, Lill R, Pierik A, et al. The essential cytosolic iron-sulfur protein Nbp35 acts without Cfd1 partner in the green lineage. J Biol Chem. 2008;283:35797-804 pubmed publisher..These results show that despite considerable divergence from the yeast Cfd1-Nbp35 Fe-S scaffold complex, AtNBP35 has retained similar Fe-S cluster binding and transfer properties and performs an essential function. ..
- Smith M, Telfer S, Kallio E, Burthe S, Cook A, Lambin X, et al. Host-pathogen time series data in wildlife support a transmission function between density and frequency dependence. Proc Natl Acad Sci U S A. 2009;106:7905-9 pubmed publisher..Our study illustrates how time series data of the host-pathogen dynamics, especially of the number of susceptible individuals, can greatly facilitate the fitting of mechanistic disease models. ..
- Margos G, Vollmer S, Cornet M, Garnier M, Fingerle V, Wilske B, et al. A new Borrelia species defined by multilocus sequence analysis of housekeeping genes. Appl Environ Microbiol. 2009;75:5410-6 pubmed publisher..We suggest that OspA serotype 4 strains be raised to species status and named Borrelia bavariensis sp. nov. The rooted phylogenetic trees provide novel insights into the evolutionary history of LB spirochetes...
- Metcalfe H, Best A, Kanellos T, La Ragione R, Werling D. Flagellin expression enhances Salmonella accumulation in TLR5-positive macrophages. Dev Comp Immunol. 2010;34:797-804 pubmed publisher..This study suggests that flagellin may be inducing TLR5-dependent internalisation mechanisms in Mcapital EF, Cyrillic which vary qualitatively between different species and Salmonella serotypes. ..
- Burdfield Steel E, Dougherty L, Smith L, Collins L, Shuker D. Variation in social and sexual behaviour in four species of aposematic seed bugs (Hemiptera: Lygaeidae): the role of toxic and non-toxic food. Behav Processes. 2013;99:52-61 pubmed publisher..We discuss our findings in terms of the evolution of aposematism, the importance of automimicry, and the role of diet in generating behavioural variation. ..
- Krasovec R, Richards H, Gifford D, Hatcher C, Faulkner K, Belavkin R, et al. Spontaneous mutation rate is a plastic trait associated with population density across domains of life. PLoS Biol. 2017;15:e2002731 pubmed publisher..Such a prevalent environmental association and conserved mechanism suggest that mutation has varied plastically with population density since the early origins of life. ..
- Davis E, Henderson P. The cloning and DNA sequence of the gene xylE for xylose-proton symport in Escherichia coli K12. J Biol Chem. 1987;262:13928-32 pubmed..coli and glucose transport proteins of mammals. Structural analyses and comparisons suggest that 12 membrane-spanning segments may occur in the XylE protein. ..
- Fiore Donno A, Haskins E, Pawlowski J, Cavalier Smith T. Semimorula liquescens is a modified echinostelid myxomycete (Mycetozoa). Mycologia. 2009;101:773-6 pubmed..Semimorula liquescens therefore might be a useful negative model to search for genes inducing stalk formation during sporulation...
- Aguirre J, Morrell N, Long L, Clift P, Upton P, Polak J, et al. Vascular remodeling and ET-1 expression in rat strains with different responses to chronic hypoxia. Am J Physiol Lung Cell Mol Physiol. 2000;278:L981-7 pubmed
- Diggle C, Shires M, Leitch D, Brooke D, Carr I, Markham A, et al. Ketohexokinase: expression and localization of the principal fructose-metabolizing enzyme. J Histochem Cytochem. 2009;57:763-74 pubmed publisher..Our results highlight that the use of in vivo biological controls (tissues from knockout animals) is required to distinguish genuine KHK immunoreactivity from experimental artifact. ..
- Strudwick N, Brown M, Parmar V, Schroder M. Ime1 and Ime2 are required for pseudohyphal growth of Saccharomyces cerevisiae on nonfermentable carbon sources. Mol Cell Biol. 2010;30:5514-30 pubmed publisher..Based on these findings, we propose to include exit from pseudohyphal growth and entry into meiosis in the life cycle of S. cerevisiae. ..
- Ryzhakov G, Teixeira A, Saliba D, Blazek K, Muta T, Ragoussis J, et al. Cross-species analysis reveals evolving and conserved features of the nuclear factor ?B (NF-?B) proteins. J Biol Chem. 2013;288:11546-54 pubmed publisher..Surprisingly, the Bcl3-type nuclear I?B proteins functionally pair up only with NF-?B derived from their own species. The basis of the differential NF-?B recognition by I?B subfamilies is discussed. ..
- Amarilla S, Gómez Laguna J, Carrasco L, Rodríguez Gómez I, Caridad Y Ocerín J, Graham S, et al. Thymic depletion of lymphocytes is associated with the virulence of PRRSV-1 strains. Vet Microbiol. 2016;188:47-58 pubmed publisher..Our results demonstrate that different PRRSV-1 strains induced depletion of the thymic cortex due to apoptosis of thymocytes and that the most severe depletion was associated with the highly virulent SU1-bel strain. ..
- Peixoto A, Campesan S, Costa R, Kyriacou C. Molecular evolution of a repetitive region within the per gene of Drosophila. Mol Biol Evol. 1993;10:127-39 pubmed publisher..Furthermore, analysis of the data suggests that changes in the length of this variable region might be associated with amino acid replacements in the more conserved flanking sequences...
- Amici F, Aureli F, Call J. Fission-fusion dynamics, behavioral flexibility, and inhibitory control in primates. Curr Biol. 2008;18:1415-9 pubmed publisher..These findings confirmed that enhanced inhibitory skills are positively associated with FF dynamics, more than to phylogenetic relations or feeding ecology...
- Mars R, Sallet J, Neubert F, Rushworth M. Connectivity profiles reveal the relationship between brain areas for social cognition in human and monkey temporoparietal cortex. Proc Natl Acad Sci U S A. 2013;110:10806-11 pubmed publisher..These results suggest that macaque face processing areas and human mentalizing areas might have a similar precursor. ..
- Goldet G, Wait A, Cracknell J, Vincent K, Ludwig M, Lenz O, et al. Hydrogen production under aerobic conditions by membrane-bound hydrogenases from Ralstonia species. J Am Chem Soc. 2008;130:11106-13 pubmed publisher..Consequently, H2 can be produced sustainably in the presence of O2 as long as the H2 is removed continuously, thereby proving the feasibility for biological H2 production in air...
- Bebber D, Carine M, Wood J, Wortley A, Harris D, Prance G, et al. Herbaria are a major frontier for species discovery. Proc Natl Acad Sci U S A. 2010;107:22169-71 pubmed publisher..Effort, funding, and research focus should, therefore, be directed as much to examining extant herbarium material as collecting new material in the field. ..
- Graham J, Kurian D, Agarwal S, Toovey L, Hunt L, Kirby L, et al. Na+/K+-ATPase is present in scrapie-associated fibrils, modulates PrP misfolding in vitro and links PrP function and dysfunction. PLoS ONE. 2011;6:e26813 pubmed publisher..Since functional interactions between PrP(C) and Na(+)/K(+)-ATPase have previously been reported in astrocytes, our data highlight this molecule as a key link between PrP function, dysfunction and misfolding. ..
- Fox B, Devonshire A, Schutte M, Foy C, Minguez J, Przyborski S, et al. Validation of reference gene stability for APAP hepatotoxicity studies in different in vitro systems and identification of novel potential toxicity biomarkers. Toxicol In Vitro. 2010;24:1962-70 pubmed publisher..We conclude that accurate quantification of gene expression requires the use of a validated normalisation strategy for each species and experimental system employed. ..
- Pemberton A, Knight P, Gamble J, Colledge W, Lee J, Pierce M, et al. Innate BALB/c enteric epithelial responses to Trichinella spiralis: inducible expression of a novel goblet cell lectin, intelectin-2, and its natural deletion in C57BL/10 mice. J Immunol. 2004;173:1894-901 pubmed..spiralis infection suggest that this novel lectin may serve a protective role in the innate immune response to parasite infection...
- Lewis R, Godfrey K, Jackson A, Cameron I, Hanson M. Low serine hydroxymethyltransferase activity in the human placenta has important implications for fetal glycine supply. J Clin Endocrinol Metab. 2005;90:1594-8 pubmed publisher..The low activity of SHMT in the human and rat placenta suggests that, unlike in the sheep, placental conversion of serine to glycine is not a major source of fetal glycine in these species...
- Philippides A, Ott S, Husbands P, Lovick T, O SHEA M. Modeling cooperative volume signaling in a plexus of nitric-oxide-synthase-expressing neurons. J Neurosci. 2005;25:6520-32 pubmed..We propose that the fineness-dependent properties of volume signals may in part account for the presence of similar NOS plexus morphologies in distantly related animals. ..
- Harvey C, Bassett J, Maruvada P, Yen P, Williams G. The rat thyroid hormone receptor (TR) Deltabeta3 displays cell-, TR isoform-, and thyroid hormone response element-specific actions. Endocrinology. 2007;148:1764-73 pubmed..Analysis of these complex responses implicates a range of nuclear corepressors and coactivators as cell-, TR isoform-, and TRE-specific modulators of T3 action. ..
- Beeton M, Chalker V, Maxwell N, Kotecha S, Spiller O. Concurrent titration and determination of antibiotic resistance in ureaplasma species with identification of novel point mutations in genes associated with resistance. Antimicrob Agents Chemother. 2009;53:2020-7 pubmed publisher..It is now possible to detect antibiotic resistance in Ureaplasma within 48 h of positive culture without prior knowledge of bacterial load, identifying them for further molecular analysis...
- Mattison J, Kool J, Uren A, de Ridder J, Wessels L, Jonkers J, et al. Novel candidate cancer genes identified by a large-scale cross-species comparative oncogenomics approach. Cancer Res. 2010;70:883-95 pubmed publisher..Collectively, this work provides a rich catalogue of new candidate cancer genes for functional analysis. ..
- Wanaguru M, Liu W, Hahn B, Rayner J, Wright G. RH5-Basigin interaction plays a major role in the host tropism of Plasmodium falciparum. Proc Natl Acad Sci U S A. 2013;110:20735-40 pubmed publisher..falciparum to its human host...
- Tate C, Muiry J, Henderson P. Mapping, cloning, expression, and sequencing of the rhaT gene, which encodes a novel L-rhamnose-H+ transport protein in Salmonella typhimurium and Escherichia coli. J Biol Chem. 1992;267:6923-32 pubmed..Both rhaT genes encoded a hydrophobic protein of 344 amino acids (91% identical) that contained 10 putative transmembrane regions. The RhaT protein represents a novel class of sugar transport protein. ..
- Modun B, Kendall D, Williams P. Staphylococci express a receptor for human transferrin: identification of a 42-kilodalton cell wall transferrin-binding protein. Infect Immun. 1994;62:3850-8 pubmed..These data show that the staphylococci express a specific receptor for human transferrin based at least in part on a common 42-kDa cell wall protein. ..
- Baumann P, Benson F, West S. Human Rad51 protein promotes ATP-dependent homologous pairing and strand transfer reactions in vitro. Cell. 1996;87:757-66 pubmed..It is proposed that hRad51 mediates homology recognition and initiates strand exchange, but that extensive heteroduplex formation in higher organisms requires the actions of additional proteins. ..
- White A, Watson R, Newman B, Freemont A, Wallis G. Annexin VIII is differentially expressed by chondrocytes in the mammalian growth plate during endochondral ossification and in osteoarthritic cartilage. J Bone Miner Res. 2002;17:1851-8 pubmed..Thus annexin VIII is a marker for chondrocyte differentiation during normal endochondral ossification and may act as a marker for cells undergoing inappropriate differentiation in OA. ..