Experts and Doctors on sodium dependent organic anion transporters in United States


Locale: United States
Topic: sodium dependent organic anion transporters

Top Publications

  1. Shang Q, Saumoy M, Holst J, Salen G, Xu G. Colesevelam improves insulin resistance in a diet-induced obesity (F-DIO) rat model by increasing the release of GLP-1. Am J Physiol Gastrointest Liver Physiol. 2010;298:G419-24 pubmed publisher
    ..It is unlikely that the improvement is attributable to decreased bile acid flux to the liver but is likely secondary to induced GLP-1 secretion, which improves insulin release. ..
  2. Talluri R, Katragadda S, Pal D, Mitra A. Mechanism of L-ascorbic acid uptake by rabbit corneal epithelial cells: evidence for the involvement of sodium-dependent vitamin C transporter 2. Curr Eye Res. 2006;31:481-9 pubmed
    ..A saturable, sodium dependent, and pH sensitive transporter with high specificity for L-ascorbic acid was functionally characterized and was identified as SVCT2. ..
  3. Fan X, Monnier V. Vitamin C-mediated Maillard reaction in the lens probed in a transgenic-mouse model. Ann N Y Acad Sci. 2008;1126:194-200 pubmed publisher
    ..Treatment of the mice with nucleophilic inhibitors can slow down the process, opening new avenues for the pharmacological prevention of senile cataractogenesis. ..
  4. Kuo S, Tan C, Dragan M, Wilson J. Endotoxin increases ascorbate recycling and concentration in mouse liver. J Nutr. 2005;135:2411-6 pubmed
    ..The enhanced rate of ascorbate production from DHAA may protect these organs against the reactive oxygen species produced by subsequent, potentially lethal challenges. ..
  5. Slitt A, Allen K, Morrone J, Aleksunes L, Chen C, Maher J, et al. Regulation of transporter expression in mouse liver, kidney, and intestine during extrahepatic cholestasis. Biochim Biophys Acta. 2007;1768:637-47 pubmed
  6. Cao J, Gowri P, Ganguly T, Wood M, Hyde J, Talamantes F, et al. PRL, placental lactogen, and GH induce NA(+)/taurocholate-cotransporting polypeptide gene expression by activating signal transducer and activator of transcription-5 in liver cells. Endocrinology. 2001;142:4212-22 pubmed
  7. Mottino A, Hoffman T, Dawson P, Luquita M, Monti J, Sanchez Pozzi E, et al. Increased expression of ileal apical sodium-dependent bile acid transporter in postpartum rats. Am J Physiol Gastrointest Liver Physiol. 2002;282:G41-50 pubmed
    ..Together with the marked increase in intestinal mass observed at peak lactation, these data indicate a significant increase in asbt-mediated reclamation of bile acids in the intestine of lactating rats. ..
  8. Wilson J. Regulation of vitamin C transport. Annu Rev Nutr. 2005;25:105-25 pubmed
    ..Evidence is reviewed indicating that these transport pathways are regulated under physiological conditions and altered by aging and disease. ..
  9. Fan X, Reneker L, Obrenovich M, Strauch C, Cheng R, Jarvis S, et al. Vitamin C mediates chemical aging of lens crystallins by the Maillard reaction in a humanized mouse model. Proc Natl Acad Sci U S A. 2006;103:16912-7 pubmed
    ..The hSVCT2 mouse is expected to facilitate the search for drugs that inhibit damage by vitamin C oxidation products. ..

More Information


  1. Faaland C, Race J, Ricken G, Warner F, Williams W, Holtzman E. Molecular characterization of two novel transporters from human and mouse kidney and from LLC-PK1 cells reveals a novel conserved family that is homologous to bacterial and Aspergillus nucleobase transporters. Biochim Biophys Acta. 1998;1442:353-60 pubmed
    ..Further functional studies will be needed to unveil the role of these transporters in nucleic acid metabolism in normal and in disease states. ..
  2. Michels A, Hagen T. Hepatocyte nuclear factor 1 is essential for transcription of sodium-dependent vitamin C transporter protein 1. Am J Physiol Cell Physiol. 2009;297:C1220-7 pubmed publisher
    ..Together, these data suggest that HNF-1alpha and/or HNF-1beta binding is required for SVCT1 expression and may be involved in the coordinate regulation of whole body vitamin C status. ..
  3. Varma S, Sobey K, Campbell C, Kuo S. Hierarchal contribution of N- and C-terminal sequences to the differential localization of homologous sodium-dependent vitamin C transporters, SVCT1 and SVCT2, in epithelial cells. Biochemistry. 2009;48:2969-80 pubmed publisher
    ..The involvement of both intracellularly localized termini of multipass membrane proteins in the sorting pathway suggests a more complex sorting mechanism compared to that for single-pass proteins. ..
  4. Reidling J, Subramanian V, Dahhan T, Sadat M, Said H. Mechanisms and regulation of vitamin C uptake: studies of the hSVCT systems in human liver epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2008;295:G1217-27 pubmed publisher
    ..These studies are the first to determine the overall ascorbic acid uptake process and relative expression, regulation, and contribution of the hSVCT systems in human liver epithelial cells. ..
  5. Cheng X, Buckley D, Klaassen C. Regulation of hepatic bile acid transporters Ntcp and Bsep expression. Biochem Pharmacol. 2007;74:1665-76 pubmed
    ..In conclusion, mouse Ntcp and Bsep are regulated by age, gender, cholestyramine, and bile acid, but resistant to induction by most microsomal enzyme inducers...
  6. Han Y, Busler D, Hong Y, Tian Y, Chen C, Rodrigues A. Transporter studies with the 3-O-sulfate conjugate of 17alpha-ethinylestradiol: assessment of human liver drug transporters. Drug Metab Dispos. 2010;38:1072-82 pubmed publisher
    ..9 and K(m2) = 307 microM). Collectively, the data show that hepatic uptake of EE2-Sul can be mediated by three transporters (OATP1B1, OATP2B1, and NTCP), whereas biliary excretion of EE2-Sul into bile likely involves BCRP...
  7. Csanaky I, Aleksunes L, Tanaka Y, Klaassen C. Role of hepatic transporters in prevention of bile acid toxicity after partial hepatectomy in mice. Am J Physiol Gastrointest Liver Physiol. 2009;297:G419-33 pubmed publisher
    ..5-fold more BAs and three times more phospholipids per gram liver than the sham-operated mouse liver. Upregulation of phospholipid transport may be important in protecting the biliary tract from BA toxicity during PHx...
  8. Varma S, Campbell C, Kuo S. Functional role of conserved transmembrane segment 1 residues in human sodium-dependent vitamin C transporters. Biochemistry. 2008;47:2952-60 pubmed publisher
  9. Johnston L, Laverty G. Vitamin C transport and SVCT1 transporter expression in chick renal proximal tubule cells in culture. Comp Biochem Physiol A Mol Integr Physiol. 2007;146:327-34 pubmed
    ..Vitamin C transport and conservation by the kidney is likely to be especially critical in birds, due to high plasma glucose levels and resulting high levels of reactive oxygen species. ..
  10. Boyer J, Campbell C, Sigurdson W, Kuo S. Polarized localization of vitamin C transporters, SVCT1 and SVCT2, in epithelial cells. Biochem Biophys Res Commun. 2005;334:150-6 pubmed
    ..This differential epithelial membrane distribution and function suggests non-redundant functions of these two isoforms. ..
  11. Kuo S, MacLean M, McCormick K, Wilson J. Gender and sodium-ascorbate transporter isoforms determine ascorbate concentrations in mice. J Nutr. 2004;134:2216-21 pubmed
    ..Additionally, lower ascorbate excretion in females may elevate the vitamin's concentrations in plasma and tissues expressing SVCT1 that, unlike SVCT2, is not saturated by plasma ascorbate concentrations. ..
  12. Monteiro I, David E, Ferraris R. Ontogenetic development of rat intestinal bile acid transport requires thyroxine but not corticosterone. Pediatr Res. 2004;55:611-21 pubmed
    ..Hence, endogenous thyroxine but not corticosterone regulates the developmentally timed appearance of ASBT. ..
  13. Cao J, Wood M, Liu Y, Hoffman T, Hyde J, Park Sarge O, et al. Estradiol represses prolactin-induced expression of Na+/taurocholate cotransporting polypeptide in liver cells through estrogen receptor-alpha and signal transducers and activators of transcription 5a. Endocrinology. 2004;145:1739-49 pubmed
    ..These data also establish a novel mechanism by which expression of ntcp, an important hepatic bile acid transporter, can be regulated by multiple hormones. ..
  14. Fei Y, Inoue K, Ganapathy V. Structural and functional characteristics of two sodium-coupled dicarboxylate transporters (ceNaDC1 and ceNaDC2) from Caenorhabditis elegans and their relevance to life span. J Biol Chem. 2003;278:6136-44 pubmed
    ..elegans may lead to decreased availability of dicarboxylates for cellular production of metabolic energy, thus creating a biological state similar to that of caloric restriction, and consequently leading to life span extension. ..
  15. Wang H, Fei Y, Kekuda R, Yang Feng T, Devoe L, Leibach F, et al. Structure, function, and genomic organization of human Na(+)-dependent high-affinity dicarboxylate transporter. Am J Physiol Cell Physiol. 2000;278:C1019-30 pubmed
    ..The human NaDC3 gene is located on chromosome 20q12-13.1, as evidenced by fluorescent in situ hybridization. The gene is >80 kbp long and consists of 13 exons and 12 introns...
  16. Cheng X, Klaassen C. Critical role of PPAR-alpha in perfluorooctanoic acid- and perfluorodecanoic acid-induced downregulation of Oatp uptake transporters in mouse livers. Toxicol Sci. 2008;106:37-45 pubmed publisher
    ..In conclusion, PFOA and PFDA decrease mouse liver uptake transporters primarily via activation of PPAR-alpha. ..