Experts and Doctors on snare proteins in United Kingdom


Locale: United Kingdom
Topic: snare proteins

Top Publications

  1. Prescott G, Gorleku O, Greaves J, Chamberlain L. Palmitoylation of the synaptic vesicle fusion machinery. J Neurochem. 2009;110:1135-49 pubmed publisher
    ..In this review, we discuss the mechanisms and dynamics of palmitoylation of these proteins and speculate on how palmitoylation might contribute to the regulation of synaptic vesicle fusion. ..
  2. Rickman C, Jimenez J, Graham M, Archer D, Soloviev M, Burgoyne R, et al. Conserved prefusion protein assembly in regulated exocytosis. Mol Biol Cell. 2006;17:283-94 pubmed
  3. Gokhale A, Mullin A, Zlatic S, Easley C, Merritt M, Raj N, et al. The N-ethylmaleimide-sensitive factor and dysbindin interact to modulate synaptic plasticity. J Neurosci. 2015;35:7643-53 pubmed publisher
    ..Our results demonstrate that dysbindin/BLOC-1 expression defects result in altered cellular content of proteins of the vesicle fusion apparatus and therefore influence synaptic plasticity. ..
  4. Kioumourtzoglou D, Gould G, Bryant N. Insulin stimulates syntaxin4 SNARE complex assembly via a novel regulatory mechanism. Mol Cell Biol. 2014;34:1271-9 pubmed publisher
    ..Hence, this report provides molecular detail of how the cell alters membrane traffic in response to an external stimulus, in this case, insulin...
  5. Yang L, Dun A, Martin K, Qiu Z, Dunn A, Lord G, et al. Secretory vesicles are preferentially targeted to areas of low molecular SNARE density. PLoS ONE. 2012;7:e49514 pubmed publisher
    ..Together our results provide a new model for the molecular mechanism of regulated exocytosis and demonstrate the exquisite organization of the plasma membrane at the level of individual molecular machines...
  6. Smyth A, Rickman C, Duncan R. Vesicle fusion probability is determined by the specific interactions of munc18. J Biol Chem. 2010;285:38141-8 pubmed publisher
    ..We therefore conclude that interaction with the syntaxin N-peptide can confer differential release probabilities to secretory vesicles and may contribute to the delineation of secretory vesicle pools. ..
  7. Granata A, Watson R, Collinson L, Schiavo G, Warner T. The dystonia-associated protein torsinA modulates synaptic vesicle recycling. J Biol Chem. 2008;283:7568-79 pubmed publisher
    ..This may affect neuronal uptake of neurotransmitters, such as dopamine, playing a role in the development of dystonic movements...
  8. Duguid I, Pankratov Y, Moss G, Smart T. Somatodendritic release of glutamate regulates synaptic inhibition in cerebellar Purkinje cells via autocrine mGluR1 activation. J Neurosci. 2007;27:12464-74 pubmed
    ..We propose that activity-dependent somatodendritic glutamate release and autocrine activation of mGluR1 on PCs provides a powerful homeostatic mechanism to dynamically regulate inhibitory synaptic transmission in the cerebellar cortex. ..
  9. Steel G, Laude A, Boojawan A, Harvey D, Morgan A. Biochemical analysis of the Saccharomyces cerevisiae SEC18 gene product: implications for the molecular mechanism of membrane fusion. Biochemistry. 1999;38:7764-72 pubmed
    ..We conclude that the mechanistic properties of NSF and SNAPs are shared by Sec18p and Sec17p, thus demonstrating that the biochemistry of membrane fusion is conserved from yeast to mammals. ..

More Information


  1. Pickett J, Thorn P, Edwardson J. The plasma membrane Q-SNARE syntaxin 2 enters the zymogen granule membrane during exocytosis in the pancreatic acinar cell. J Biol Chem. 2005;280:1506-11 pubmed
    ..We conclude that syntaxin 2 enters the membrane of a fused zymogen granule after the opening of the fusion pore, and we suggest that this movement might permit the onset of secondary fusion. ..
  2. Hirst J, Miller S, Taylor M, von Mollard G, Robinson M. EpsinR is an adaptor for the SNARE protein Vti1b. Mol Biol Cell. 2004;15:5593-602 pubmed
    ..These findings provide in vivo evidence that epsinR is an adaptor for vti1b, and they also show that CCV isolation can be used as an assay for adaptor function. ..
  3. Rickman C, Davletov B. Mechanism of calcium-independent synaptotagmin binding to target SNAREs. J Biol Chem. 2003;278:5501-4 pubmed
  4. Gillingham A, Pfeifer A, Munro S. CASP, the alternatively spliced product of the gene encoding the CCAAT-displacement protein transcription factor, is a Golgi membrane protein related to giantin. Mol Biol Cell. 2002;13:3761-74 pubmed
    ..The conserved histidine is necessary for Coy1p's activity in cells lacking Gos1p, suggesting that the TMD of these transmembrane Golgi coiled-coil proteins is directly involved in their function. ..
  5. Siniossoglou S, Pelham H. Vps51p links the VFT complex to the SNARE Tlg1p. J Biol Chem. 2002;277:48318-24 pubmed
    ..Recent evidence suggests that components of a number of rab/ypt effector complexes share a common, distantly related helical coiled-coil motif. We show that each VFT subunit requires this coiled-coil motif for assembly into the complex. ..
  6. Hu K, Carroll J, Rickman C, Davletov B. Action of complexin on SNARE complex. J Biol Chem. 2002;277:41652-6 pubmed
    ..We propose that complexin facilitates neuronal exocytosis by promoting interaction between the complementary syntaxin and synaptobrevin transmembrane regions that reside in opposing membranes prior to fusion. ..
  7. Muller J, Shorter J, Newman R, Deinhardt K, Sagiv Y, Elazar Z, et al. Sequential SNARE disassembly and GATE-16-GOS-28 complex assembly mediated by distinct NSF activities drives Golgi membrane fusion. J Cell Biol. 2002;157:1161-73 pubmed
    ..We suggest that this occurs at the inception of Golgi reassembly to protect the v-SNARE and regulate SNARE function. ..
  8. Darios F, Niranjan D, Ferrari E, Zhang F, Soloviev M, Rummel A, et al. SNARE tagging allows stepwise assembly of a multimodular medicinal toxin. Proc Natl Acad Sci U S A. 2010;107:18197-201 pubmed publisher
    ..Together, these results demonstrate that the SNARE tetrahelical coiled-coil allows controlled linking of various building blocks into multifunctional assemblies. ..
  9. Chamberlain L, Burgoyne R, Gould G. SNARE proteins are highly enriched in lipid rafts in PC12 cells: implications for the spatial control of exocytosis. Proc Natl Acad Sci U S A. 2001;98:5619-24 pubmed publisher
    ..The results described suggest that the interaction of SNARE proteins with lipid rafts is important for exocytosis and may allow structural and spatial organization of the secretory machinery...