Experts and Doctors on small interfering rna in United States


Locale: United States
Topic: small interfering rna

Top Publications

  1. Cao Y, Zhao Z, Gruszczynska Biegala J, Zolkiewska A. Role of metalloprotease disintegrin ADAM12 in determination of quiescent reserve cells during myogenic differentiation in vitro. Mol Cell Biol. 2003;23:6725-38 pubmed
    ..Our results suggest that ADAM12-mediated adhesion and/or signaling may play a role in determination of the pool of reserve cells during myoblast differentiation. ..
  2. Xin M, Deng X. Nicotine inactivation of the proapoptotic function of Bax through phosphorylation. J Biol Chem. 2005;280:10781-9 pubmed
    ..Thus, nicotine-induced survival and chemoresistance of human lung cancer cells may occur in a novel mechanism involving activation of PI3K/AKT that directly phosphorylates and inactivates the proapoptotic function of Bax. ..
  3. Iczkowski K, Omara Opyene A, Shah G. The predominant CD44 splice variant in prostate cancer binds fibronectin, and calcitonin stimulates its expression. Anticancer Res. 2006;26:2863-72 pubmed
    ..Calcitonin influenced PC's balance between CD44s and CD44v. CD44v controlled invasiveness, altered ligand binding, and provides a target for therapeutic intervention. ..
  4. Wong S, Wakefield D, Klein J, Monahan S, Rozema D, Lewis D, et al. Hepatocyte targeting of nucleic acid complexes and liposomes by a T7 phage p17 peptide. Mol Pharm. 2006;3:386-97 pubmed
    ..This was primarily due to failure of delivered cargo to escape the endosomes. Further studies are in progress to provide functional activity of delivered nucleic acids by enabling their endosomal escape. ..
  5. Zheng D, Oh S, Jung Y, Petersen B. Oval cell response in 2-acetylaminofluorene/partial hepatectomy rat is attenuated by short interfering RNA targeted to stromal cell-derived factor-1. Am J Pathol. 2006;169:2066-74 pubmed
    ..These results indicate that SDF-1 is an essential molecule needed in oval cell activation. ..
  6. Gonsalvez G, Tian L, Ospina J, Boisvert F, Lamond A, Matera A. Two distinct arginine methyltransferases are required for biogenesis of Sm-class ribonucleoproteins. J Cell Biol. 2007;178:733-40 pubmed
    ..Furthermore, we show that the two enzymes function nonredundantly in Sm protein methylation. Lastly, we provide in vivo evidence demonstrating that Sm protein sDMA modification is required for snRNP biogenesis in human cells. ..
  7. Venkataraman K, Lee Y, Michaud J, Thangada S, Ai Y, Bonkovsky H, et al. Vascular endothelium as a contributor of plasma sphingosine 1-phosphate. Circ Res. 2008;102:669-76 pubmed publisher
    ..These data suggest that the vascular endothelium, in addition to the hematopoietic system, is a major contributor of plasma S1P. ..
  8. Gao J, Zhao N, Knutson M, Enns C. The hereditary hemochromatosis protein, HFE, inhibits iron uptake via down-regulation of Zip14 in HepG2 cells. J Biol Chem. 2008;283:21462-8 pubmed publisher
    ..Further analysis of protein turnover indicated that the half-life of Zip14 is lower in cells that express HFE. These results suggest that HFE decreases the stability of Zip14 and therefore reduces the iron loading in HepG2 cells. ..
  9. Barlos D, Deitch E, Watkins A, Caputo F, Lu Q, Abungu B, et al. Trauma-hemorrhagic shock-induced pulmonary epithelial and endothelial cell injury utilizes different programmed cell death signaling pathways. Am J Physiol Lung Cell Mol Physiol. 2009;296:L404-17 pubmed publisher
    ..Collectively, T/HS-induced pulmonary endothelial PCD occurs via an AIF-dependent caspase-independent pathway, whereas epithelial cells undergo apoptosis by a caspase-dependent pathway...

More Information

Publications313 found, 100 shown here

  1. Bonoiu A, Mahajan S, Ding H, Roy I, Yong K, Kumar R, et al. Nanotechnology approach for drug addiction therapy: gene silencing using delivery of gold nanorod-siRNA nanoplex in dopaminergic neurons. Proc Natl Acad Sci U S A. 2009;106:5546-50 pubmed publisher
    ..Therefore, these nanoplexes appear to be suited for brain-specific delivery of appropriate siRNA for therapy of drug addiction and other brain diseases. ..
  2. Menendez J, Vellon L, Mehmi I, Oza B, Ropero S, Colomer R, et al. Inhibition of fatty acid synthase (FAS) suppresses HER2/neu (erbB-2) oncogene overexpression in cancer cells. Proc Natl Acad Sci U S A. 2004;101:10715-20 pubmed
  3. Yamawaki H, Pan S, Lee R, Berk B. Fluid shear stress inhibits vascular inflammation by decreasing thioredoxin-interacting protein in endothelial cells. J Clin Invest. 2005;115:733-8 pubmed
    ..The data suggest that TXNIP and TRX are key components of biomechanical signal transduction and establish them as potentially novel regulators of TNF signaling and inflammation in ECs. ..
  4. Lou Z, Minter Dykhouse K, Chen J. BRCA1 participates in DNA decatenation. Nat Struct Mol Biol. 2005;12:589-93 pubmed
    ..Together these results suggest an important role of BRCA1 in DNA decatenation and reveal a previously unknown function of BRCA1 in the maintenance of genomic stability. ..
  5. Li J, Yang Z, Yu B, Liu J, Chen X. Methylation protects miRNAs and siRNAs from a 3'-end uridylation activity in Arabidopsis. Curr Biol. 2005;15:1501-7 pubmed
    ..We conclude that 3'-end methylation is a common step in miRNA and siRNA metabolism and likely protects the 3' ends of the small RNAs from the uridylation activity. ..
  6. Song K, Wang H, Krebs T, Danielpour D. Novel roles of Akt and mTOR in suppressing TGF-beta/ALK5-mediated Smad3 activation. EMBO J. 2006;25:58-69 pubmed
    ..We propose a novel model whereby Akt suppresses activation of S3 in an Akt kinase-dependent manner through mTOR, a likely route for loss of tumor suppression by TGF-beta in cancers. ..
  7. Zella L, Kim S, Shevde N, Pike J. Enhancers located within two introns of the vitamin D receptor gene mediate transcriptional autoregulation by 1,25-dihydroxyvitamin D3. Mol Endocrinol. 2006;20:1231-47 pubmed
    ..The location of these regulatory regions and their apparent distances from the TSS are consistent with new findings suggesting the emerging relevance of distant enhancers. ..
  8. Qiu K, Su Y, Block E. Use of recombinant calpain-2 siRNA adenovirus to assess calpain-2 modulation of lung endothelial cell migration and proliferation. Mol Cell Biochem. 2006;292:69-78 pubmed
    ..These results indicate that adenoviral vector harboring calpain-2 siRNA expression unit is a valuable tool to study the biology of calpains and that calpain-2 plays an important role in lung endothelial cell migration and proliferation. ..
  9. Chen X, Zhang J, Baker S, Chen G. Human constitutive androstane receptor mediated methotrexate induction of human dehydroepiandrosterone sulfotransferase (hSULT2A1). Toxicology. 2007;231:224-33 pubmed
    ..In summary, we identified an IR2 DNA cis-element located at -186/-173 of hSULT2A1 promoter region; the IR2 element mediates the MTX induction of hSULT2A1 through interacting with hCAR and hRXRalpha. ..
  10. Garrett Engele C, Tasch M, Hwang H, Fero M, Perlmutter R, Clurman B, et al. A mechanism misregulating p27 in tumors discovered in a functional genomic screen. PLoS Genet. 2007;3:e219 pubmed
    ..Thus, we have identified and characterized transcriptional repression of p27 by Id3 as a new mechanism decreasing p27 protein in tumors...
  11. Elcheva I, Tarapore R, Bhatia N, Spiegelman V. Overexpression of mRNA-binding protein CRD-BP in malignant melanomas. Oncogene. 2008;27:5069-74 pubmed publisher
    ..Knockdown of CRD-BP inhibits NF-kappaB activity, induces apoptosis, and suppresses proliferation and tumorigenic properties of melanoma cells. ..
  12. Hitomi M, Yang K, Stacey A, Stacey D. Phosphorylation of cyclin D1 regulated by ATM or ATR controls cell cycle progression. Mol Cell Biol. 2008;28:5478-93 pubmed publisher
    ..These results indicate that checkpoint kinases play a critical role in regulating cell cycle progression in normal and stressed cells by directing the phosphorylation of cyclin D1. ..
  13. Blumenstiel J, Fu R, Theurkauf W, Hawley R. Components of the RNAi machinery that mediate long-distance chromosomal associations are dispensable for meiotic and early somatic homolog pairing in Drosophila melanogaster. Genetics. 2008;180:1355-65 pubmed publisher
    ..Thus, there appears to be at least two mechanisms that bring homologous sequences together within the nucleus: those that act between dispersed homologous sequences and those that act to align and pair homologous chromosomes. ..
  14. Saperstein S, Chen L, Oakes D, Pryhuber G, Finkelstein J. IL-1beta augments TNF-alpha-mediated inflammatory responses from lung epithelial cells. J Interferon Cytokine Res. 2009;29:273-84 pubmed publisher
    ..These data suggest IL-1beta modulates TNF-alpha-mediated inflammatory lung diseases by enhancing epithelial cell TNF receptor surface expression. ..
  15. Adler J, Cook M, Luo Y, Pitt S, Ju J, Li W, et al. Tautomycetin and tautomycin suppress the growth of medullary thyroid cancer cells via inhibition of glycogen synthase kinase-3beta. Mol Cancer Ther. 2009;8:914-20 pubmed publisher
    ..Importantly, we describe a novel action of these compounds: inhibition of glycogen synthase kinase-3beta. ..
  16. Martinez L, Goluszko E, Chen H, Leone G, Post S, Lozano G, et al. E2F3 is a mediator of DNA damage-induced apoptosis. Mol Cell Biol. 2010;30:524-36 pubmed publisher
    ..Finally, using both in vitro and in vivo approaches, we establish that E2f3 is required for DNA damage-induced apoptosis. Thus, our data reveal the novel ability of E2f3 to function as a master regulator of the DNA damage response. ..
  17. Strickland K, Hoeferlin L, Oleinik N, Krupenko N, Krupenko S. Acyl carrier protein-specific 4'-phosphopantetheinyl transferase activates 10-formyltetrahydrofolate dehydrogenase. J Biol Chem. 2010;285:1627-33 pubmed publisher
    ..Our study identifies human PPT as the FDH-modifying enzyme and supports the hypothesis that mammals utilize a single enzyme for all phosphopantetheinylation reactions. ..
  18. Naik M, Vuppalanchi D, Naik U. Essential role of junctional adhesion molecule-1 in basic fibroblast growth factor-induced endothelial cell migration. Arterioscler Thromb Vasc Biol. 2003;23:2165-71 pubmed
    ..These data thus implicate JAM-1 as an integral part of both bFGF and ERK signaling pathways in endothelial cells. ..
  19. Zhang Q, Yoshimatsu Y, Hildebrand J, Frisch S, Goodman R. Homeodomain interacting protein kinase 2 promotes apoptosis by downregulating the transcriptional corepressor CtBP. Cell. 2003;115:177-86 pubmed
    ..Finally, reduction in CtBP levels, either by genetic knockout or siRNA, promoted apoptosis in p53-deficient cells. These findings provide a pathway for UV-induced apoptosis in cells lacking p53. ..
  20. Franco S, Perrin B, Huttenlocher A. Isoform specific function of calpain 2 in regulating membrane protrusion. Exp Cell Res. 2004;299:179-87 pubmed
    ..Together, our findings support a novel role for calpain 2 in limiting membrane protrusions and in regulating lamellipodial dynamics at the leading edge of migrating cells. ..
  21. Wu X, Shell S, Zou Y. Interaction and colocalization of Rad9/Rad1/Hus1 checkpoint complex with replication protein A in human cells. Oncogene. 2005;24:4728-35 pubmed
    ..Taken together, our results suggest that 9-1-1 and RPA complexes collaboratively function in DNA damage responses, and that the RPA may serve as a regulator for the activity of 9-1-1 complex in the cellular checkpoint network. ..
  22. Hirsch A, Medigeshi G, Meyers H, DeFilippis V, Fruh K, Briese T, et al. The Src family kinase c-Yes is required for maturation of West Nile virus particles. J Virol. 2005;79:11943-51 pubmed
    ..These results identify c-Yes as a cellular protein that is involved in WNV assembly and egress. ..
  23. Natesampillai S, Fernandez Zapico M, Urrutia R, Veldhuis J. A novel functional interaction between the Sp1-like protein KLF13 and SREBP-Sp1 activation complex underlies regulation of low density lipoprotein receptor promoter function. J Biol Chem. 2006;281:3040-7 pubmed
  24. Huang C, Wu Z, Hujer K, Miller R. Silencing of filamin A gene expression inhibits Ca2+ -sensing receptor signaling. FEBS Lett. 2006;580:1795-800 pubmed
    ..This work defines filamin A involvement in GPCR signaling pathways and describes an additional method for studying its function. ..
  25. Ada Nguema A, Xenias H, Hofman J, Wiggins C, Sheetz M, Keely P. The small GTPase R-Ras regulates organization of actin and drives membrane protrusions through the activity of PLCepsilon. J Cell Sci. 2006;119:1307-19 pubmed
    ..Overall, these data suggest that R-Ras signaling regulates the organization of the actin cytoskeleton to sustain membrane protrusion through the activity of PLCepsilon. ..
  26. McCollum A, Teneyck C, Sauer B, Toft D, Erlichman C. Up-regulation of heat shock protein 27 induces resistance to 17-allylamino-demethoxygeldanamycin through a glutathione-mediated mechanism. Cancer Res. 2006;66:10967-75 pubmed
    ..Our results suggest that Hsp27 up-regulation has a significant role in 17-AAG resistance, which may be mediated in part through GSH regulation. Clinical modulation of GSH may therefore enhance the efficacy of Hsp90-directed therapy. ..
  27. Heidel J, Yu Z, Liu J, Rele S, Liang Y, Zeidan R, et al. Administration in non-human primates of escalating intravenous doses of targeted nanoparticles containing ribonucleotide reductase subunit M2 siRNA. Proc Natl Acad Sci U S A. 2007;104:5715-21 pubmed
    ..Taken together, the data presented show that multiple, systemic doses of targeted nanoparticles containing nonchemically modified siRNA can safely be administered to non-human primates. ..
  28. Howell M, Fahlgren N, Chapman E, Cumbie J, Sullivan C, Givan S, et al. Genome-wide analysis of the RNA-DEPENDENT RNA POLYMERASE6/DICER-LIKE4 pathway in Arabidopsis reveals dependency on miRNA- and tasiRNA-directed targeting. Plant Cell. 2007;19:926-42 pubmed
    ..We suggest that posttranscriptional silencing mechanisms operate on an evolutionary scale to buffer the effects of rapidly expanding gene families. ..
  29. Thirunavukkarasu M, Han Z, Zhan L, Penumathsa S, Menon V, Maulik N. Adeno-sh-beta-catenin abolishes ischemic preconditioning-mediated cardioprotection by downregulation of its target genes VEGF, Bcl-2, and survivin in ischemic rat myocardium. Antioxid Redox Signal. 2008;10:1475-84 pubmed publisher
    ..These findings indicated for the first time that silencing beta-catenin abolished IP-mediated cardioprotection, probably through inhibition of VEGF-Bcl-2 and survivin. ..
  30. Hussain S, Perlman S, Gallagher T. Severe acute respiratory syndrome coronavirus protein 6 accelerates murine hepatitis virus infections by more than one mechanism. J Virol. 2008;82:7212-22 pubmed publisher
    ..Thus, the SARS-CoV protein 6 accelerates MHV infections by more than one mechanism...
  31. Chen Deutsch X, Garay E, Zhang J, Harrison J, Studzinski G. c-Jun N-terminal kinase 2 (JNK2) antagonizes the signaling of differentiation by JNK1 in human myeloid leukemia cells resistant to vitamin D. Leuk Res. 2009;33:1372-8 pubmed publisher
    ..In contrast, KD of JNK1p46 reduced the intensity of DCS-induced differentiation, and partially abrogated activation of c-Jun/AP-1 transcription factors. ..
  32. Xu Y, Josson S, Fang F, Oberley T, St Clair D, Wan X, et al. RelB enhances prostate cancer growth: implications for the role of the nuclear factor-kappaB alternative pathway in tumorigenicity. Cancer Res. 2009;69:3267-71 pubmed publisher
  33. Wendt M, Schiemann W. Therapeutic targeting of the focal adhesion complex prevents oncogenic TGF-beta signaling and metastasis. Breast Cancer Res. 2009;11:R68 pubmed publisher
  34. Vajda N, Brimacombe K, LeMasters K, Ladd A. Muscleblind-like 1 is a negative regulator of TGF-beta-dependent epithelial-mesenchymal transition of atrioventricular canal endocardial cells. Dev Dyn. 2009;238:3266-72 pubmed publisher
    ..This reveals a novel role for MBNL1 during embryonic development, and represents the first evidence that an alternative splicing regulator is a key player in endocardial cushion development. ..
  35. Zhang P, Sridharan D, Lambert M. Knockdown of mu-calpain in Fanconi anemia, FA-A, cells by siRNA restores alphaII spectrin levels and corrects chromosomal instability and defective DNA interstrand cross-link repair. Biochemistry. 2010;49:5570-81 pubmed publisher
    ..Thus, by reducing the level of breakdown of alphaIISp in FA cells, we may be able to reverse a number of the cellular deficiencies observed in this disorder. ..
  36. Linsley P, Jackson A. Hidden reach of the micromanagers. BMC Biol. 2010;8:53 pubmed publisher
    ..A recent study in BMC Genomics shows that microRNA-like effects can predominate among the 'hits' of functional genomics screens. ..
  37. Prunier C, Howe P. Disabled-2 (Dab2) is required for transforming growth factor beta-induced epithelial to mesenchymal transition (EMT). J Biol Chem. 2005;280:17540-8 pubmed
    ..Our findings indicate that Dab2 plays an important regulatory role during cellular differentiation and that induction of differentiation in the absence of Dab2 expression commits the cell to apoptosis. ..
  38. Huynh L, Thangavel M, Chen T, Cottrell R, Mitchell J, Praetorius Ibba M. Linking tRNA localization with activation of nutritional stress responses. Cell Cycle. 2010;9:3112-8 pubmed publisher
    ..This suggests that subcellular localization of tRNAs may regulate an intracellular response to starvation independently of the cellular nutritional status. ..
  39. Liao X, Zhang L, Thrasher J, Du J, Li B. Glycogen synthase kinase-3beta suppression eliminates tumor necrosis factor-related apoptosis-inducing ligand resistance in prostate cancer. Mol Cancer Ther. 2003;2:1215-22 pubmed
  40. Studebaker A, Lafuse W, Kloesel R, Williams M. Modulation of human dUTPase using small interfering RNA. Biochem Biophys Res Commun. 2005;327:306-10 pubmed
  41. Mukerji I, Ramkissoon S, Reddy K, Rameshwar P. Autocrine proliferation of neuroblastoma cells is partly mediated through neurokinin receptors: relevance to bone marrow metastasis. J Neurooncol. 2005;71:91-8 pubmed
    ..The results show potential roles for NK receptors in the proliferation of NB. ..
  42. Reu F, Leaman D, Maitra R, Bae S, Cherkassky L, Fox M, et al. Expression of RASSF1A, an epigenetically silenced tumor suppressor, overcomes resistance to apoptosis induction by interferons. Cancer Res. 2006;66:2785-93 pubmed
    ..Results identified RASSF1A as regulated by IFNs and participating in IFN-induced apoptosis at least in part by sensitization to TRAIL. ..
  43. Zhang Q, Wang S, Nottke A, Rocheleau J, Piston D, Goodman R. Redox sensor CtBP mediates hypoxia-induced tumor cell migration. Proc Natl Acad Sci U S A. 2006;103:9029-33 pubmed
    ..We propose that CtBP senses levels of free NADH to control expression of cell adhesion genes, thereby promoting tumor cell migration under hypoxic stress. ..
  44. Yang S, Misner B, Chiu R, Meyskens F. Redox effector factor-1, combined with reactive oxygen species, plays an important role in the transformation of JB6 cells. Carcinogenesis. 2007;28:2382-90 pubmed
  45. Gondi C, Lakka S, Dinh D, Olivero W, Gujrati M, Rao J. Intraperitoneal injection of a hairpin RNA-expressing plasmid targeting urokinase-type plasminogen activator (uPA) receptor and uPA retards angiogenesis and inhibits intracranial tumor growth in nude mice. Clin Cancer Res. 2007;13:4051-60 pubmed
    ..In conclusion, the plasmid-expressed RNAi targeting uPAR and uPA via the i.p. route has potential clinical applications for the treatment of glioma. ..
  46. Andino L, Takeda M, Kasahara H, Jakymiw A, Byrne B, Lewin A. AAV-mediated knockdown of phospholamban leads to improved contractility and calcium handling in cardiomyocytes. J Gene Med. 2008;10:132-42 pubmed
    ..Our results suggest that AAV-delivered shRNAs mediated physiologically significant suppression of phospholamban that may be useful in combating the effects of chronic heart failure. ..
  47. Yan G, Chen S, You B, Sun J. Activation of sphingosine kinase-1 mediates induction of endothelial cell proliferation and angiogenesis by epoxyeicosatrienoic acids. Cardiovasc Res. 2008;78:308-14 pubmed publisher
    ..Thus, SK1 may represent a novel therapeutic modality for the treatment of angiogenesis-related diseases such as cancer and ischaemia. ..
  48. Paintlia M, Paintlia A, Contreras M, Singh I, Singh A. Lipopolysaccharide-induced peroxisomal dysfunction exacerbates cerebral white matter injury: attenuation by N-acetyl cysteine. Exp Neurol. 2008;210:560-76 pubmed publisher
  49. Whitten C, Swygert S, Butler S, Finco T. Transcription of the LAT gene is regulated by multiple binding sites for Sp1 and Sp3. Gene. 2008;413:58-66 pubmed publisher
    ..Collectively, these results provide compelling data that implicates Sp1 and Sp3 in the transcriptional regulation of the human LAT gene. ..
  50. Wang W, Zhang X, Mize G, Takayama T. Protease-activated receptor-1 upregulates fibroblast growth factor 7 in stroma of benign prostatic hyperplasia. Prostate. 2008;68:1064-75 pubmed publisher
    ..The expression and function of PAR-1 in BPH stroma indicate PAR-1 may play important roles in BPH pathogenesis. ..
  51. Li M, Chiu J, Gagne J, Fukagawa N. Age-related differences in insulin-like growth factor-1 receptor signaling regulates Akt/FOXO3a and ERK/Fos pathways in vascular smooth muscle cells. J Cell Physiol. 2008;217:377-87 pubmed publisher
    ..Therefore, activation of IGF-1R signaling influences VSMC function in old rats and may contribute to the increased risk for atherosclerosis. ..
  52. Hoot K, Lighthall J, Han G, Lu S, Li A, Ju W, et al. Keratinocyte-specific Smad2 ablation results in increased epithelial-mesenchymal transition during skin cancer formation and progression. J Clin Invest. 2008;118:2722-32 pubmed publisher
    ..Our data suggest that enhanced Smad3/Smad4-mediated Snail transcription contributed to Smad2 loss-associated EMT during skin carcinogenesis. ..
  53. Kalantari P, Narayan V, Natarajan S, Muralidhar K, Gandhi U, Vunta H, et al. Thioredoxin reductase-1 negatively regulates HIV-1 transactivating protein Tat-dependent transcription in human macrophages. J Biol Chem. 2008;283:33183-90 pubmed publisher
    ..Increasing TR1 expression along with other selenoproteins by supplementing with selenium suggests a potential inexpensive adjuvant therapy for HIV/AIDS patients. ..
  54. Tang Y, Scheef E, Wang S, Sorenson C, Marcus C, Jefcoate C, et al. CYP1B1 expression promotes the proangiogenic phenotype of endothelium through decreased intracellular oxidative stress and thrombospondin-2 expression. Blood. 2009;113:744-54 pubmed publisher
    ..Evidence is presented that similar changes occur in retinal endothelium in vivo to limit neovascularization. ..
  55. Davis M. The first targeted delivery of siRNA in humans via a self-assembling, cyclodextrin polymer-based nanoparticle: from concept to clinic. Mol Pharm. 2009;6:659-68 pubmed publisher
    ..The four component formulation is self-assembled into nanoparticles in the pharmacy and administered intravenously (iv) to patients. The designed features of this experimental therapeutic are described, and their functions illustrated. ..
  56. Dai H, Meng X, Lee S, Schneider P, Kaufmann S. Context-dependent Bcl-2/Bak interactions regulate lymphoid cell apoptosis. J Biol Chem. 2009;284:18311-22 pubmed publisher
    ..Thus, the ability of Bcl-2 to protect cells from activated Bak depends on two important contextual variables, the identity of the Bcl-2 present and the amount expressed. ..
  57. Holley A, Kiningham K, Spitz D, Edwards D, Jenkins J, Moore M. Progestin stimulation of manganese superoxide dismutase and invasive properties in T47D human breast cancer cells. J Steroid Biochem Mol Biol. 2009;117:23-30 pubmed publisher
    ..To our knowledge, this is the first characterization of progestin stimulation of MnSOD in human breast cancer cells. ..
  58. Howard P, Jue S, Maurer R. Expression of the synaptotagmin I gene is enhanced by binding of the pituitary-specific transcription factor, POU1F1. Mol Endocrinol. 2009;23:1563-71 pubmed publisher
  59. Vickers T, Lima W, Wu H, Nichols J, Linsley P, Crooke S. Off-target and a portion of target-specific siRNA mediated mRNA degradation is Ago2 'Slicer' independent and can be mediated by Ago1. Nucleic Acids Res. 2009;37:6927-41 pubmed publisher
    ..Finally, we present data suggesting that a significant portion of on-target siRNA activity is also Ago2 cleavage independent, however, this activity does not appear to be P-body associated. ..
  60. Qian J, Perchiniak E, Sun K, Groden J. The mitochondrial protein hTID-1 partners with the caspase-cleaved adenomatous polyposis cell tumor suppressor to facilitate apoptosis. Gastroenterology. 2010;138:1418-28 pubmed publisher
    ..These data suggest that the amino-terminal segment of APC promotes cell sensitivity to apoptosis modulated through its binding to 40- and 43-kilodalton hTID-1 isoforms. ..
  61. Samarin J, Wessel J, Cicha I, Kroening S, Warnecke C, Goppelt Struebe M. FoxO proteins mediate hypoxic induction of connective tissue growth factor in endothelial cells. J Biol Chem. 2010;285:4328-36 pubmed publisher
    ..Our findings provide evidence that FoxO1, hypoxia-stimulated expression of FoxO3a and its nuclear accumulation are required for the induction of CTGF by hypoxia in endothelial cells. ..
  62. Yu B, Bi L, Zhai J, Agarwal M, Li S, Wu Q, et al. siRNAs compete with miRNAs for methylation by HEN1 in Arabidopsis. Nucleic Acids Res. 2010;38:5844-50 pubmed publisher
    ..In addition, our findings imply the existence of a negative modifier of HEN1 activity in the Columbia genetic background. ..
  63. Raghu H, Lakka S, Gondi C, Mohanam S, Dinh D, Gujrati M, et al. Suppression of uPA and uPAR attenuates angiogenin mediated angiogenesis in endothelial and glioblastoma cell lines. PLoS ONE. 2010;5:e12458 pubmed publisher
  64. Wan M, Tang Y, Tytler E, Lu C, Jin B, Vickers S, et al. Smad4 protein stability is regulated by ubiquitin ligase SCF beta-TrCP1. J Biol Chem. 2004;279:14484-7 pubmed
    ..Thus, SCF(beta-TrCP1) abrogates TGF-beta function in vivo by decreasing Smad4 stability. ..
  65. Yamanaka M, Shegogue D, Pei H, Bu S, Bielawska A, Bielawski J, et al. Sphingosine kinase 1 (SPHK1) is induced by transforming growth factor-beta and mediates TIMP-1 up-regulation. J Biol Chem. 2004;279:53994-4001 pubmed
    ..Together, these experiments demonstrate that SphK/S1P are important components of the TGF-beta signaling pathway involved in up-regulation of the TIMP-1 gene. ..
  66. Misra S, Ghatak S, Toole B. Regulation of MDR1 expression and drug resistance by a positive feedback loop involving hyaluronan, phosphoinositide 3-kinase, and ErbB2. J Biol Chem. 2005;280:20310-5 pubmed
    ..This pathway may also be important in progression of other malignant characteristics. These results illustrate the potential importance of hyaluronan as a therapeutic target in multidrug-resistant carcinomas. ..
  67. Wang Z, Dillon T, Pokala V, Mishra S, Labudda K, Hunter B, et al. Rap1-mediated activation of extracellular signal-regulated kinases by cyclic AMP is dependent on the mode of Rap1 activation. Mol Cell Biol. 2006;26:2130-45 pubmed
    ..We propose a model that specific GEFs activate distinct pools of Rap1 that are differentially coupled to downstream effectors. ..
  68. James S, Link P, Karpf A. Epigenetic regulation of X-linked cancer/germline antigen genes by DNMT1 and DNMT3b. Oncogene. 2006;25:6975-85 pubmed
    ..In summary, DNMT1 and DNMT3b were found to perform both redundant and independent functions in epigenetic regulation of CG-X antigen genes in human cancer cells. ..
  69. Macey T, Lowe J, Chavkin C. Mu opioid receptor activation of ERK1/2 is GRK3 and arrestin dependent in striatal neurons. J Biol Chem. 2006;281:34515-24 pubmed
    ..These results support the hypothesis that MOR activation of ERK1/2 requires opioid receptor phosphorylation by GRK3 and association of arrestin3 to initiate the cascade resulting in ERK1/2 phosphorylation in striatal neurons. ..
  70. Dashti N, Manchekar M, Liu Y, Sun Z, Segrest J. Microsomal triglyceride transfer protein activity is not required for the initiation of apolipoprotein B-containing lipoprotein assembly in McA-RH7777 cells. J Biol Chem. 2007;282:28597-608 pubmed
    ..Our results provide a compelling argument that the initial addition of phospholipids to apoB:1000 and initiation of apoB-containing lipoprotein assembly occur independently of MTP lipid transfer activity. ..
  71. Kinney C, Chandrasekharan U, Mavrakis L, DiCorleto P. VEGF and thrombin induce MKP-1 through distinct signaling pathways: role for MKP-1 in endothelial cell migration. Am J Physiol Cell Physiol. 2008;294:C241-50 pubmed
    ..Overall, these results demonstrate distinct MAPK signaling pathways for thrombin versus VEGF induction of MKP-1 in ECs and point to the importance of MKP-1 induction in VEGF-stimulated EC migration. ..
  72. Ding H, Dolan P, Johnson G. Histone deacetylase 6 interacts with the microtubule-associated protein tau. J Neurochem. 2008;106:2119-30 pubmed publisher
    ..These findings establish HDAC6 as a tau-interacting protein and as a potential modulator of tau phosphorylation and accumulation. ..
  73. Mannava S, Grachtchouk V, Wheeler L, Im M, Zhuang D, Slavina E, et al. Direct role of nucleotide metabolism in C-MYC-dependent proliferation of melanoma cells. Cell Cycle. 2008;7:2392-400 pubmed
    ..Our data establish a novel functional link between C-MYC and dNTP metabolism and identify its role in proliferation of tumor cells. ..
  74. Chudakova D, Zeidan Y, Wheeler B, Yu J, Novgorodov S, Kindy M, et al. Integrin-associated Lyn kinase promotes cell survival by suppressing acid sphingomyelinase activity. J Biol Chem. 2008;283:28806-16 pubmed publisher
    ..The data suggest a novel mechanism for regulation of ASMase activity during cell adhesion in which Lyn acts as a key upstream kinase that may play a critical role in cerebral IR injury. ..
  75. Pichiorri F, Okumura H, Nakamura T, Garrison P, Gasparini P, Suh S, et al. Correlation of fragile histidine triad (Fhit) protein structural features with effector interactions and biological functions. J Biol Chem. 2009;284:1040-9 pubmed publisher
  76. Moreb J, Baker H, Chang L, Amaya M, Lopez M, Ostmark B, et al. ALDH isozymes downregulation affects cell growth, cell motility and gene expression in lung cancer cells. Mol Cancer. 2008;7:87 pubmed publisher
    ..Aldehyde dehydrogenase isozymes ALDH1A1 and ALDH3A1 are highly expressed in non small cell lung cancer. Neither the mechanisms nor the biologic significance for such over expression have been studied...
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