Experts and Doctors on small interfering rna in France


Locale: France
Topic: small interfering rna

Top Publications

  1. Abaza A, Soleilhac J, Westendorf J, Piel M, Crevel I, Roux A, et al. M phase phosphoprotein 1 is a human plus-end-directed kinesin-related protein required for cytokinesis. J Biol Chem. 2003;278:27844-52 pubmed
    ..MPP1 suppression by RNA interference induces failure of cell division late in cytokinesis. We conclude that MPP1 is a new mitotic molecular motor required for completion of cytokinesis. ..
  2. Hassani Z, Lemkine G, Erbacher P, Palmier K, Alfama G, Giovannangeli C, et al. Lipid-mediated siRNA delivery down-regulates exogenous gene expression in the mouse brain at picomolar levels. J Gene Med. 2005;7:198-207 pubmed
    ..We tested the capacity of different non-viral vectors and formulation methods for inhibition of exogenous (luciferase) gene expression when used to introduce small interfering RNA (siRNA) into the mouse brain in vivo...
  3. Pelisson A, Sarot E, Payen Groschêne G, Bucheton A. A novel repeat-associated small interfering RNA-mediated silencing pathway downregulates complementary sense gypsy transcripts in somatic cells of the Drosophila ovary. J Virol. 2007;81:1951-60 pubmed
  4. Mével Ninio M, Pelisson A, Kinder J, Campos A, Bucheton A. The flamenco locus controls the gypsy and ZAM retroviruses and is required for Drosophila oogenesis. Genetics. 2007;175:1615-24 pubmed
    ..Our results suggest that flamenco extends proximally to DIP1, spanning >130 kb of transposon-rich heterochromatin. We propose a model explaining the multiple functions of this large heterochromatic locus. ..
  5. Fombonne J, Charrier C, Goddard I, Moyse E, Krantic S. Leptin-mediated decrease of cyclin A2 and increase of cyclin D1 expression: relevance for the control of prepubertal rat Leydig cell division and differentiation. Endocrinology. 2007;148:2126-37 pubmed
    ..Altogether, our data show that leptin inhibits division of prepubertal Leydig cells via a cyclin D-independent mechanism and suggest that cyclin D1 might be involved in leptin-induced differentiation of Leydig cells. ..
  6. Belot M, Abdennebi Najar L, Gaudin F, Emilie D, Machelon V. Progesterone increases csk homologous kinase in HMC-1560 human mast cells and reduces cell proliferation. J Cell Biochem. 2007;102:1271-80 pubmed
    ..This effect parallels decreases in the phosphorylated forms of Raf-1 and p42/44 MAPK, as their production depends on Src kinase activity. ..
  7. Moissiard G, Parizotto E, Himber C, Voinnet O. Transitivity in Arabidopsis can be primed, requires the redundant action of the antiviral Dicer-like 4 and Dicer-like 2, and is compromised by viral-encoded suppressor proteins. RNA. 2007;13:1268-78 pubmed
    ..Finally, we show that target cleavage by a primary small RNA and 3-->5' transitivity can be genetically uncoupled, and we provide in vivo evidence supporting a key role for priming in this specific reaction. ..
  8. Ingueneau C, Huynh Do U, Thiers J, Negre Salvayre A, Salvayre R, Vindis C. Caveolin-1 sensitizes vascular smooth muscle cells to mildly oxidized LDL-induced apoptosis. Biochem Biophys Res Commun. 2008;369:889-93 pubmed publisher
    ..These findings provide new insights about the potential role of caveolin-1 in the regulation of oxLDL-induced apoptosis in vascular cells and its contribution to the instability of the plaque. ..
  9. Monferran S, Skuli N, Delmas C, Favre G, Bonnet J, Cohen Jonathan Moyal E, et al. Alphavbeta3 and alphavbeta5 integrins control glioma cell response to ionising radiation through ILK and RhoB. Int J Cancer. 2008;123:357-364 pubmed publisher

More Information

Publications121 found, 100 shown here

  1. Chambeyron S, Popkova A, Payen Groschêne G, Brun C, Laouini D, Pelisson A, et al. piRNA-mediated nuclear accumulation of retrotransposon transcripts in the Drosophila female germline. Proc Natl Acad Sci U S A. 2008;105:14964-9 pubmed publisher
    ..Our results indicate that piRNAs are involved in a posttranscriptional gene-silencing mechanism resulting in RNA nuclear accumulation. ..
  2. Delloye Bourgeois C, Fitamant J, Paradisi A, Cappellen D, Douc Rasy S, Raquin M, et al. Netrin-1 acts as a survival factor for aggressive neuroblastoma. J Exp Med. 2009;206:833-47 pubmed publisher
  3. Ameyar Zazoua M, Souidi M, Fritsch L, Robin P, Thomas A, Hamiche A, et al. Physical and functional interaction between heterochromatin protein 1alpha and the RNA-binding protein heterogeneous nuclear ribonucleoprotein U. J Biol Chem. 2009;284:27974-9 pubmed publisher
    ..Thus, our data demonstrate that hnRNP U is involved in HP1alpha function, shedding new light on the mode of action of HP1alpha and on the function of hnRNP U. ..
  4. Gironella M, Malicet C, Cano C, Sandi M, Hamidi T, Tauil R, et al. p8/nupr1 regulates DNA-repair activity after double-strand gamma irradiation-induced DNA damage. J Cell Physiol. 2009;221:594-602 pubmed publisher
    ..MSL1-dependent HAT activity, which is negatively regulated by the stress protein p8, induces chromatin remodeling and relaxation allowing access to DNA of the repair machinery. ..
  5. Grelier G, Voirin N, Ay A, Cox D, Chabaud S, Treilleux I, et al. Prognostic value of Dicer expression in human breast cancers and association with the mesenchymal phenotype. Br J Cancer. 2009;101:673-83 pubmed publisher
    ..Assessment of Dicer expression may facilitate prediction of distant metastases for patients suffering from breast cancer. ..
  6. Mallory A, Hinze A, Tucker M, Bouche N, Gasciolli V, Elmayan T, et al. Redundant and specific roles of the ARGONAUTE proteins AGO1 and ZLL in development and small RNA-directed gene silencing. PLoS Genet. 2009;5:e1000646 pubmed publisher
  7. Fagegaltier D, Bouge A, Berry B, Poisot E, Sismeiro O, Coppee J, et al. The endogenous siRNA pathway is involved in heterochromatin formation in Drosophila. Proc Natl Acad Sci U S A. 2009;106:21258-63 pubmed publisher
    ..Similar effects were observed in dcr2, r2d2, and ago2 mutants. Our findings provide evidence that a nuclear pool of TE-derived endo-siRNAs is involved in heterochromatin formation in somatic tissues in Drosophila. ..
  8. Toumaniantz G, Ferland McCollough D, Cario Toumaniantz C, Pacaud P, Loirand G. The Rho protein exchange factor Vav3 regulates vascular smooth muscle cell proliferation and migration. Cardiovasc Res. 2010;86:131-40 pubmed publisher
  9. Adenot X, Elmayan T, Lauressergues D, Boutet S, Bouche N, Gasciolli V, et al. DRB4-dependent TAS3 trans-acting siRNAs control leaf morphology through AGO7. Curr Biol. 2006;16:927-32 pubmed
  10. Genin P, Lin R, Hiscott J, Civas A. Differential regulation of human interferon A gene expression by interferon regulatory factors 3 and 7. Mol Cell Biol. 2009;29:3435-50 pubmed publisher
    ..This regulatory mechanism contributes to differential expression of IFN-A genes and may be critical for alpha interferon production in different cell types by RIG-I-dependent signals, leading to innate antiviral immune responses. ..
  11. Malicet C, Giroux V, Vasseur S, Dagorn J, Neira J, Iovanna J. Regulation of apoptosis by the p8/prothymosin alpha complex. Proc Natl Acad Sci U S A. 2006;103:2671-6 pubmed
    ..These results strongly suggest that the antiapoptotic response of HeLa cells upon staurosporine treatment requires expression of both p8 and ProTalpha. ..
  12. Salaun B, Coste I, Rissoan M, Lebecque S, Renno T. TLR3 can directly trigger apoptosis in human cancer cells. J Immunol. 2006;176:4894-901 pubmed
  13. Kypriotou M, Beauchef G, Chadjichristos C, Widom R, Renard E, Jimenez S, et al. Human collagen Krox up-regulates type I collagen expression in normal and scleroderma fibroblasts through interaction with Sp1 and Sp3 transcription factors. J Biol Chem. 2007;282:32000-14 pubmed
  14. Fritah A, Saucier C, De Wever O, Bracke M, Bieche I, Lidereau R, et al. Role of WISP-2/CCN5 in the maintenance of a differentiated and noninvasive phenotype in human breast cancer cells. Mol Cell Biol. 2008;28:1114-23 pubmed
    ..We propose that WISP-2/CCN5 is an important regulator involved in the maintenance of a differentiated phenotype in breast tumor epithelial cells and may play a role in tumor cell invasion and metastasis. ..
  15. Grechez Cassiau A, Rayet B, Guillaumond F, Teboul M, Delaunay F. The circadian clock component BMAL1 is a critical regulator of p21WAF1/CIP1 expression and hepatocyte proliferation. J Biol Chem. 2008;283:4535-42 pubmed
    ..These data establish a novel molecular link between clock and cell cycle genes and suggest that the G1 progression phase is a target of the circadian clock during liver cell proliferation. ..
  16. Lafont E, Milhas D, Carpentier S, Garcia V, Jin Z, Umehara H, et al. Caspase-mediated inhibition of sphingomyelin synthesis is involved in FasL-triggered cell death. Cell Death Differ. 2010;17:642-54 pubmed publisher
    ..Altogether, our data show that SMS1 is a novel caspase target that is functionally involved in the regulation of FasL-induced apoptosis. ..
  17. Fonte C, Grenier J, Trousson A, Chauchereau A, Lahuna O, Baulieu E, et al. Involvement of {beta}-catenin and unusual behavior of CBP and p300 in glucocorticosteroid signaling in Schwann cells. Proc Natl Acad Sci U S A. 2005;102:14260-5 pubmed
  18. Teixeira F, Heredia F, Sarazin A, Roudier F, Boccara M, Ciaudo C, et al. A role for RNAi in the selective correction of DNA methylation defects. Science. 2009;323:1600-4 pubmed publisher
    ..Our findings suggest an important role for RNAi in protecting genomes against long-term epigenetic defects. ..
  19. Ruiz Ferrer V, Voinnet O. Roles of plant small RNAs in biotic stress responses. Annu Rev Plant Biol. 2009;60:485-510 pubmed publisher
  20. Martinkova E, Maglott A, Leger D, Bonnet D, Stiborova M, Takeda K, et al. alpha5beta1 integrin antagonists reduce chemotherapy-induced premature senescence and facilitate apoptosis in human glioblastoma cells. Int J Cancer. 2010;127:1240-8 pubmed publisher
  21. Benaud C, Gentil B, Assard N, Court M, Garin J, Delphin C, et al. AHNAK interaction with the annexin 2/S100A10 complex regulates cell membrane cytoarchitecture. J Cell Biol. 2004;164:133-44 pubmed
    ..We propose that the interaction of AHNAK with the annexin 2/S100A10 regulates cortical actin cytoskeleton organization and cell membrane cytoarchitecture. ..
  22. Jaillard C, Harrison S, Stankoff B, Aigrot M, Calver A, Duddy G, et al. Edg8/S1P5: an oligodendroglial receptor with dual function on process retraction and cell survival. J Neurosci. 2005;25:1459-69 pubmed
  23. Bour G, Plassat J, Bauer A, Lalevée S, Rochette Egly C. Vinexin beta interacts with the non-phosphorylated AF-1 domain of retinoid receptor gamma (RARgamma) and represses RARgamma-mediated transcription. J Biol Chem. 2005;280:17027-37 pubmed
    ..We propose a model in which phosphorylation of the AF-1 domain controls RARgamma-mediated transcription through triggering the dissociation of vinexin beta. ..
  24. Hémonnot B, Cartier C, Gay B, Rebuffat S, Bardy M, Devaux C, et al. The host cell MAP kinase ERK-2 regulates viral assembly and release by phosphorylating the p6gag protein of HIV-1. J Biol Chem. 2004;279:32426-34 pubmed
    ..Altogether, these data suggest that phosphorylation of p6(gag) protein by virus-associated ERK-2 is involved in the budding stage of HIV-1 life cycle. ..
  25. Gross C, Buchwalter G, Dubois Pot H, Cler E, Zheng H, Wasylyk B. The ternary complex factor net is downregulated by hypoxia and regulates hypoxia-responsive genes. Mol Cell Biol. 2007;27:4133-41 pubmed
    ..Our results show that the Net TCF is part of the biological response to hypoxia, adding a new component to an important pathological and physiological process. ..
  26. Bonnet M, Erbacher P, Bolcato Bellemin A. Systemic delivery of DNA or siRNA mediated by linear polyethylenimine (L-PEI) does not induce an inflammatory response. Pharm Res. 2008;25:2972-82 pubmed publisher
    ..Taken together our data highlight that linear polyethylenimine is a delivery reagent of choice for nucleic acid therapeutics. ..
  27. Fossat P, Dobremez E, Bouali Benazzouz R, Favereaux A, Bertrand S, Kilk K, et al. Knockdown of L calcium channel subtypes: differential effects in neuropathic pain. J Neurosci. 2010;30:1073-85 pubmed publisher
    ..2 activation. We propose that L-type calcium channels in the spinal dorsal horn play an important role in pain processing, and that the maintenance of chronic neuropathic pain depends specifically on channels comprising Ca(V)1.2. ..
  28. Fabre Lafay S, Garrido Urbani S, Reymond N, Goncalves A, Dubreuil P, Lopez M. Nectin-4, a new serological breast cancer marker, is a substrate for tumor necrosis factor-alpha-converting enzyme (TACE)/ADAM-17. J Biol Chem. 2005;280:19543-50 pubmed
    ..Interestingly, the active form of TACE is overexpressed in breast tumors and may indicate that TACE is responsible for Nectin-4 shedding not only in vitro but also in vivo. ..
  29. Chassot A, Turchi L, Virolle T, Fitsialos G, Batoz M, Deckert M, et al. Id3 is a novel regulator of p27kip1 mRNA in early G1 phase and is required for cell-cycle progression. Oncogene. 2007;26:5772-83 pubmed
    ..In conclusion, this study identifies a novel mechanism of p27 regulation which besides p27 protein degradation also implicates a transcriptional mechanism mediated by Id3. ..
  30. Dolcini V, Dunys J, Sevalle J, Chen F, Guillot Sestier M, St George Hyslop P, et al. TMP21 regulates Abeta production but does not affect caspase-3, p53, and neprilysin. Biochem Biophys Res Commun. 2008;371:69-74 pubmed publisher
    ..Overall, our functional data further reinforce the view that TMP21 behaves as a regulator of gamma- but not epsilon-cleavages generated by PS-dependent gamma-secretase complex. ..
  31. Firlej V, Ladam F, Brysbaert G, Dumont P, Fuks F, De Launoit Y, et al. Reduced tumorigenesis in mouse mammary cancer cells following inhibition of Pea3- or Erm-dependent transcription. J Cell Sci. 2008;121:3393-402 pubmed publisher
  32. Molle D, Segura Morales C, Camus G, Berlioz Torrent C, Kjems J, Basyuk E, et al. Endosomal trafficking of HIV-1 gag and genomic RNAs regulates viral egress. J Biol Chem. 2009;284:19727-43 pubmed publisher
    ..Endosomal Gag-RNA complexes may be delivered at specific sites to facilitate cell-to-cell viral transmission. ..
  33. Boulon S, Pradet Balade B, Verheggen C, Molle D, Boireau S, Georgieva M, et al. HSP90 and its R2TP/Prefoldin-like cochaperone are involved in the cytoplasmic assembly of RNA polymerase II. Mol Cell. 2010;39:912-924 pubmed publisher
    ..hSpagh also bound the free RPA194 subunit of RNA polymerase I, suggesting a general role in assembling RNA polymerases. ..
  34. James C, Ugo V, Le Couedic J, Staerk J, Delhommeau F, Lacout C, et al. A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera. Nature. 2005;434:1144-8 pubmed
    ..As this mutation is also found in other myeloproliferative disorders, this unique mutation will permit a new molecular classification of these disorders and novel therapeutical approaches. ..
  35. Cailotto F, Bianchi A, Sebillaud S, Venkatesan N, Moulin D, Jouzeau J, et al. Inorganic pyrophosphate generation by transforming growth factor-beta-1 is mainly dependent on ANK induction by Ras/Raf-1/extracellular signal-regulated kinase pathways in chondrocytes. Arthritis Res Ther. 2007;9:R122 pubmed
    ..These data show that TGF-beta1 increases ePPi levels, mainly by the induction of the Ank gene, which requires activation of Ras, Raf-1, ERK, and Ca2+-dependent PKC pathways in chondrocytes. ..
  36. Grimaud C, Bantignies F, Pal Bhadra M, Ghana P, Bhadra U, Cavalli G. RNAi components are required for nuclear clustering of Polycomb group response elements. Cell. 2006;124:957-71 pubmed
    ..This suggests a novel role for the RNAi machinery in regulating the nuclear organization of PcG chromatin targets. ..
  37. Ménard L, Taras D, Grigoletto A, Haurie V, Nicou A, Dugot Senant N, et al. In vivo silencing of Reptin blocks the progression of human hepatocellular carcinoma in xenografts and is associated with replicative senescence. J Hepatol. 2010;52:681-9 pubmed publisher
    ..The blockage of tumour progression was associated with the induction of senescence and reduced cell proliferation. In vivo Reptin depletion leads to tumour growth arrest. Reptin may prove a valuable target in HCC. ..
  38. Malicet C, Hoffmeister A, Moreno S, Closa D, Dagorn J, Vasseur S, et al. Interaction of the stress protein p8 with Jab1 is required for Jab1-dependent p27 nuclear-to-cytoplasm translocation. Biochem Biophys Res Commun. 2006;339:284-9 pubmed
    ..Experiments showing that the knock-down of p8 expression results in a strong inhibition of Jab1 activity confirmed that the mechanism by which Jab1 promotes cell growth by decreasing p27 level is p8-dependent. ..
  39. Charrin S, Yalaoui S, Bartosch B, Cocquerel L, Franetich J, Boucheix C, et al. The Ig domain protein CD9P-1 down-regulates CD81 ability to support Plasmodium yoelii infection. J Biol Chem. 2009;284:31572-8 pubmed publisher
    ..Based on these data, we conclude that CD9P-1 acts as a negative regulator of P. yoelii infection by interacting with CD81 and regulating its function. ..
  40. Bougnères L, Girardin S, Weed S, Karginov A, Olivo Marin J, Parsons J, et al. Cortactin and Crk cooperate to trigger actin polymerization during Shigella invasion of epithelial cells. J Cell Biol. 2004;166:225-35 pubmed
    ..These results point at a major role for a Crk-cortactin complex in actin polymerization downstream of tyrosine kinase signaling. ..
  41. Braun V, Fraisier V, Raposo G, Hurbain I, Sibarita J, Chavrier P, et al. TI-VAMP/VAMP7 is required for optimal phagocytosis of opsonised particles in macrophages. EMBO J. 2004;23:4166-76 pubmed publisher
    ..Therefore, TI-VAMP defines a new pathway of membrane delivery required for optimal FcR-mediated phagocytosis...
  42. Prigent C, Glover D, Giet R. Drosophila Nek2 protein kinase knockdown leads to centrosome maturation defects while overexpression causes centrosome fragmentation and cytokinesis failure. Exp Cell Res. 2005;303:1-13 pubmed
    ..We discuss potential roles for DmNek2 in maintaining centrosome integrity in mitosis, during cytokinesis, and consequently for the fidelity of chromosome segregation. ..
  43. Saulnier A, Pelletier I, Labadie K, Colbere Garapin F. Complete cure of persistent virus infections by antiviral siRNAs. Mol Ther. 2006;13:142-50 pubmed
    ..The antiviral effect of specific siRNAs, consistent with a mechanism of RNA interference, correlated with a decrease in the amount of viral RNA, until its complete disappearance, resulting in cultures cured of virions and viral RNA. ..
  44. Vareille M, Rannou F, Thelier N, Glasser A, de Sablet T, Martin C, et al. Heme oxygenase-1 is a critical regulator of nitric oxide production in enterohemorrhagic Escherichia coli-infected human enterocytes. J Immunol. 2008;180:5720-6 pubmed
    ..These results highlight a new strategy elaborated by EHEC to control the host innate immune response. ..
  45. Petit Paitel A, Brau F, Cazareth J, Chabry J. Involvment of cytosolic and mitochondrial GSK-3beta in mitochondrial dysfunction and neuronal cell death of MPTP/MPP-treated neurons. PLoS ONE. 2009;4:e5491 pubmed publisher
    ..Inhibition of GSK-3beta activity might provide protection against mitochondrial stress-induced cell death. ..
  46. Béraud Dufour S, Coppola T, Massa F, Mazella J. Neurotensin receptor-2 and -3 are crucial for the anti-apoptotic effect of neurotensin on pancreatic beta-TC3 cells. Int J Biochem Cell Biol. 2009;41:2398-402 pubmed
    ..Moreover, NTSR2 and NTSR3 co-immunoprecipitate and are co-localized at the plasma membrane. Thus, the NT response in beta cells is controlled by the formation of a functional complex between NTSR2 and NTSR3. ..
  47. Maarof G, Bouchet Delbos L, Gary Gouy H, Durand Gasselin I, Krzysiek R, Dalloul A. Interleukin-24 inhibits the plasma cell differentiation program in human germinal center B cells. Blood. 2010;115:1718-26 pubmed publisher
  48. Lefebvre B, Vandewalle B, Longue J, Moerman E, Lukowiak B, Gmyr V, et al. Efficient gene delivery and silencing of mouse and human pancreatic islets. BMC Biotechnol. 2010;10:28 pubmed publisher
  49. Shankaranarayanan P, Rossin A, Khanwalkar H, Alvarez S, Alvarez R, Jacobson A, et al. Growth factor-antagonized rexinoid apoptosis involves permissive PPARgamma/RXR heterodimers to activate the intrinsic death pathway by NO. Cancer Cell. 2009;16:220-31 pubmed publisher
    ..Our results suggest a regulatory mechanism in which GF signaling antagonizes RXR-PPARgamma-mediated default apoptosis to sustain cell life. ..
  50. Bordi C, Lamy M, Ventre I, Termine E, Hachani A, Fillet S, et al. Regulatory RNAs and the HptB/RetS signalling pathways fine-tune Pseudomonas aeruginosa pathogenesis. Mol Microbiol. 2010;76:1427-43 pubmed publisher
    ..We also demonstrate a redundant action of the two sRNAs on T3SS gene expression, while the impact on pel gene expression is additive. These features underpin a novel mechanism in the fine-tuned regulation of gene expression. ..
  51. Longuet C, Broca C, Costes S, Hani E, Bataille D, Dalle S. Extracellularly regulated kinases 1/2 (p44/42 mitogen-activated protein kinases) phosphorylate synapsin I and regulate insulin secretion in the MIN6 beta-cell line and islets of Langerhans. Endocrinology. 2005;146:643-54 pubmed
    ..Taken together, our results demonstrate new aspects of the glucose-dependent actions of ERK1/2 in beta-cells exerted on cytoplasmic proteins, including synapsin I, and participating in the overall glucose-induced insulin secretion. ..
  52. Lafont J, Jacques C, Le Dreau G, Calhabeu F, Thibout H, Dubois C, et al. New target genes for NOV/CCN3 in chondrocytes: TGF-beta2 and type X collagen. J Bone Miner Res. 2005;20:2213-23 pubmed
  53. Martinez J, Seveau S, Veiga E, Matsuyama S, Cossart P. Ku70, a component of DNA-dependent protein kinase, is a mammalian receptor for Rickettsia conorii. Cell. 2005;123:1013-23 pubmed
    ..An affinity chromatography approach identified the rickettsial protein rOmpB as a ligand for Ku70. This is the first report of a receptor-ligand interaction involved in the internalization of any rickettsial species...
  54. del Nery E, Miserey Lenkei S, Falguières T, Nizak C, Johannes L, Perez F, et al. Rab6A and Rab6A' GTPases play non-overlapping roles in membrane trafficking. Traffic. 2006;7:394-407 pubmed
    ..Thus, our work shows that Rab6A and Rab6A' perform different functions within the cell and suggests a novel role for Rab6A' as the major Rab6 isoform regulating previously described Rab6-dependent transport pathways. ..
  55. Heron Milhavet L, Franckhauser C, Rana V, Berthenet C, Fisher D, Hemmings B, et al. Only Akt1 is required for proliferation, while Akt2 promotes cell cycle exit through p21 binding. Mol Cell Biol. 2006;26:8267-80 pubmed
    ..These data show that specific interaction of the Akt2 isoform with p21 is key to its negative effect on normal cell cycle progression. ..
  56. Devauchelle V, Essabbani A, De Pinieux G, Germain S, Tourneur L, Mistou S, et al. Characterization and functional consequences of underexpression of clusterin in rheumatoid arthritis. J Immunol. 2006;177:6471-9 pubmed
    ..We propose that in RA joints, high levels of extracellular CLU and low expression of intracellular CLU may enhance NF-kappaB activation and survival of the synoviocytes. ..
  57. Morris C, Wittmann J, Jack H, Jalinot P. Human INT6/eIF3e is required for nonsense-mediated mRNA decay. EMBO Rep. 2007;8:596-602 pubmed
    ..From these observations, we propose that INT6, in association with eIF3, is involved in routing specific mRNAs for degradation...
  58. Essafi Benkhadir K, Onesto C, Stebe E, Moroni C, Pages G. Tristetraprolin inhibits Ras-dependent tumor vascularization by inducing vascular endothelial growth factor mRNA degradation. Mol Biol Cell. 2007;18:4648-58 pubmed
    ..Determination of TTP and ERKs status would provide useful information for the evaluation of the angiogenic potential in human tumors. ..
  59. Monteiro P, Gilot D, Le Ferrec E, Rauch C, Lagadic Gossmann D, Fardel O. Dioxin-mediated up-regulation of aryl hydrocarbon receptor target genes is dependent on the calcium/calmodulin/CaMKIalpha pathway. Mol Pharmacol. 2008;73:769-77 pubmed
    ..Taken together, these data identified the Ca(2+)/CaM/CaMKIalpha pathway as an important contributing factor to AhR-mediated genomic response. ..
  60. Cambien B, Rezzonico R, Vitale S, Rouzaire Dubois B, Dubois J, Barthel R, et al. Silencing of hSlo potassium channels in human osteosarcoma cells promotes tumorigenesis. Int J Cancer. 2008;123:365-371 pubmed publisher
    ..Our results reveal for the first time that BK channels exhibit antitumoral properties in OS in vivo and affect the tumor microenvironment through the modulation of both chemokine expression and leukocyte infiltration. ..
  61. Vincent A, Ducourouble M, Van Seuningen I. Epigenetic regulation of the human mucin gene MUC4 in epithelial cancer cell lines involves both DNA methylation and histone modifications mediated by DNA methyltransferases and histone deacetylases. FASEB J. 2008;22:3035-45 pubmed publisher
    ..In conclusion, this work shows for the first time the importance of epigenetics in regulating MUC4 expression and may represent a new strategy to inhibit its expression in epithelial tumors. ..
  62. Lee J, Kim J, Barbier V, Fotedar A, Fotedar R. DNA damage triggers p21WAF1-dependent Emi1 down-regulation that maintains G2 arrest. Mol Biol Cell. 2009;20:1891-902 pubmed publisher
    ..This is the first demonstration that Emi1 regulation plays a role in the G2 DNA damage checkpoint. Further, our work identifies a new p21-dependent mechanism to maintain G2 arrest after DNA damage. ..
  63. Gibot L, Follet J, Metges J, Auvray P, Simon B, Corcos L, et al. Human caspase 7 is positively controlled by SREBP-1 and SREBP-2. Biochem J. 2009;420:473-83 pubmed publisher
    ..Taken together, our results show that caspase 7, as an SREBP-1/2 target, can be induced under mevalonate-restricting conditions, which might help overcome its shortage. ..
  64. Weyemi U, Caillou B, Talbot M, Ameziane El Hassani R, Lacroix L, Lagent Chevallier O, et al. Intracellular expression of reactive oxygen species-generating NADPH oxidase NOX4 in normal and cancer thyroid tissues. Endocr Relat Cancer. 2010;17:27-37 pubmed publisher
    ..Increased NOX4-p22(phox) in cancer might be related to a higher proliferation rate and tumor progression but a role in the development of tumors has to be further studied and established in the future. ..
  65. Manel N, Kim F, Kinet S, Taylor N, Sitbon M, Battini J. The ubiquitous glucose transporter GLUT-1 is a receptor for HTLV. Cell. 2003;115:449-59 pubmed
    ..Therefore, GLUT-1 is a receptor for HTLV. Perturbations in glucose metabolism resulting from interactions of HTLV envelope glycoproteins with GLUT-1 are likely to contribute to HTLV-associated disorders...
  66. Garcon L, Lacout C, Svinartchouk F, Le Couedic J, Villeval J, Vainchenker W, et al. Gfi-1B plays a critical role in terminal differentiation of normal and transformed erythroid progenitor cells. Blood. 2005;105:1448-55 pubmed
    ..Deletion of the SNAG repressor domain abolished Gfi-1B-induced erythroid maturation, strongly suggesting that Gfi-1B acts in the late stage of erythroid differentiation as a transcriptional repressor. ..
  67. Frontini M, Soutoglou E, Argentini M, Bole Feysot C, Jost B, Scheer E, et al. TAF9b (formerly TAF9L) is a bona fide TAF that has unique and overlapping roles with TAF9. Mol Cell Biol. 2005;25:4638-49 pubmed
    ..Taken together, these data demonstrate that TAF9 and TAF9b share some of their functions, but more importantly, they have distinct roles in the transcriptional regulatory process. ..
  68. Rigamonti E, Helin L, Lestavel S, Mutka A, Lepore M, Fontaine C, et al. Liver X receptor activation controls intracellular cholesterol trafficking and esterification in human macrophages. Circ Res. 2005;97:682-9 pubmed
  69. Maroun M, Delelis O, Coadou G, Bader T, Segeral E, Mbemba G, et al. Inhibition of early steps of HIV-1 replication by SNF5/Ini1. J Biol Chem. 2006;281:22736-43 pubmed
    ..K71R substitution stimulates viral replication and results in higher infectious titers. Taken together, these results suggest that, by interacting with IN, SNF5/Ini1 interferes with early steps of HIV-1 infection. ..
  70. Rival T, Soustelle L, Cattaert D, Strambi C, Iché M, Birman S. Physiological requirement for the glutamate transporter dEAAT1 at the adult Drosophila neuromuscular junction. J Neurobiol. 2006;66:1061-74 pubmed
    ..Therefore, glutamate reuptake by glial cells is required to ensure normal activity of the Drosophila NMJ, but only in adult flies. ..
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