Experts and Doctors on smad proteins in China


Locale: China
Topic: smad proteins

Top Publications

  1. Wang Y, Liang N, Yao G, Tian H, Zhai Y, Yin Y, et al. Knockdown of TrkA in cumulus oocyte complexes (COCs) inhibits EGF-induced cumulus expansion by down-regulation of IL-6. Mol Cell Endocrinol. 2014;382:804-13 pubmed publisher
    ..Understanding potential cross-points between TrkA and EGF affecting cumulus expansion will help in the discovery of new therapeutic targets in ovulation-related diseases. ..
  2. Li J, Chen K, Li S, Feng J, Liu T, Wang F, et al. Protective effect of fucoidan from Fucus vesiculosus on liver fibrosis via the TGF-β1/Smad pathway-mediated inhibition of extracellular matrix and autophagy. Drug Des Devel Ther. 2016;10:619-30 pubmed publisher
    ..Fucoidan, as an autophagy and transforming growth factor beta 1 inhibitor, could be a promising potential therapeutic agent for liver fibrosis. ..
  3. Lan H. Diverse roles of TGF-?/Smads in renal fibrosis and inflammation. Int J Biol Sci. 2011;7:1056-67 pubmed
    ..Thus, targeting the downstream TGF-?/Smad3 signaling pathway by gene transfer of either Smad7 or Smad3-dependent microRNAs may represent a specific and effective therapeutic strategy for kidney disease. ..
  4. Yu Z, Zhang J. Effect of inhaled budesonide on surfactant protein expression in asthmatic mice. Allergy Asthma Proc. 2008;29:486-92 pubmed publisher
    ..TGF-beta signaling may be a potentially important therapeutic target for antiasthma drugs. ..
  5. Jiang M, Sun Z, Dang E, Li B, Fang H, Li J, et al. TGF?/SMAD/microRNA-486-3p Signaling Axis Mediates Keratin 17 Expression and Keratinocyte Hyperproliferation in Psoriasis. J Invest Dermatol. 2017;137:2177-2186 pubmed publisher
    ..We conclude that the loss of miR-486-3p in psoriatic epidermis leads to K17 protein overexpression and contributes to the pathogenesis of psoriasis. Overexpression of miR-486-3p may therefore be a therapeutic option for psoriasis. ..
  6. Wu X, Chim S, Kuek V, Lim B, Chow S, Zhao J, et al. HtrA1 is upregulated during RANKL-induced osteoclastogenesis, and negatively regulates osteoblast differentiation and BMP2-induced Smad1/5/8, ERK and p38 phosphorylation. FEBS Lett. 2014;588:143-50 pubmed publisher
  7. Shi X, Miao S, Wu Y, Zhang W, Zhang X, Ma H, et al. Resveratrol sensitizes tamoxifen in antiestrogen-resistant breast cancer cells with epithelial-mesenchymal transition features. Int J Mol Sci. 2013;14:15655-68 pubmed publisher
    ..The molecular mechanism of resveratrol chemosensitizing effects is, at least in part, TGF-?/Smad-dependent. ..
  8. Li J, Yang L, Qin W, Zhang G, Yuan J, Wang F. Adaptive induction of growth differentiation factor 15 attenuates endothelial cell apoptosis in response to high glucose stimulus. PLoS ONE. 2013;8:e65549 pubmed publisher
    ..Our results suggest that high glucose can promote GDF15 expression and secretion in human umbilical vein endothelial cells, which in turn attenuates high glucose-induced endothelial cell apoptosis. ..
  9. Hao H, Shao Z, Tang D, Lu Q, Chen X, Yin X, et al. Preventive effects of rutin on the development of experimental diabetic nephropathy in rats. Life Sci. 2012;91:959-67 pubmed publisher
    ..Those results suggest that rutin can prevent the development of experimental DN in rats. ..

More Information


  1. Wang Y, Wang D. Protective effect of TRPV1 against renal fibrosis via inhibition of TGF-?/Smad signaling in DOCA-salt hypertension. Mol Med. 2011;17:1204-12 pubmed publisher
    ..These data suggest that activation of TRPV1 attenuates the progression of renal fibrosis possibly via suppression of the TGF-? and its downstream regulatory signaling pathway. ..
  2. Lan H, Chung A. Transforming growth factor-? and Smads. Contrib Nephrol. 2011;170:75-82 pubmed publisher
    ..In conclusion, TGF-?/Smad signaling plays a critical role in DN. A better understanding of the role of TGF-?/Smad signaling in the development of DN should provide an effective therapeutic strategy to combat DN. ..
  3. Yang C, Yang L, Wan M, Cao X. Generation of a mouse model with expression of bone morphogenetic protein type II receptor lacking the cytoplasmic domain in osteoblasts. Ann N Y Acad Sci. 2010;1192:286-91 pubmed publisher
    ..This study provides an in vivo tool to study the role of BMPRII in BMP/Smad signaling and the regulation of this pathway by PTH and Wnts. ..
  4. Hu J, Zhang Y, Liu X, Wang R, Jin Y, Xu R. Expression and localization of Smad1, Smad2 and Smad4 proteins in rat testis during postnatal development. Asian J Androl. 2003;5:51-5 pubmed
    ..The present data provide direct evidences for the molecular mechanism of TGF-bgr action in rat testes during postnatal development and spermatogenesis. ..
  5. Yang J, Zheng J, Wu L, Shi M, Zhang H, Wang X, et al. NDRG2 ameliorates hepatic fibrosis by inhibiting the TGF-?1/Smad pathway and altering the MMP2/TIMP2 ratio in rats. PLoS ONE. 2011;6:e27710 pubmed publisher
    ..In conclusion, the present findings indicate that the modulation of NDRG2 is a promising strategy for the treatment of liver fibrosis. ..
  6. Huang C, Du R, Zhang P, Meng H, Jia H, Song Y, et al. Expression, purification, and functional characterization of recombinant PTD-SARA. Acta Biochim Biophys Sin (Shanghai). 2011;43:110-7 pubmed publisher
    ..Recombinant PDT-SARA is likely to be a potential candidate for clinical prevention and treatment of renal fibrosis. ..
  7. Li Y, Fan L, Hu J, Zhang L, Liao L, Liu S, et al. MiR-26a Rescues Bone Regeneration Deficiency of Mesenchymal Stem Cells Derived From Osteoporotic Mice. Mol Ther. 2015;23:1349-1357 pubmed publisher
    ..Our findings indicate that miR-26a may be a promising therapeutic candidate to enhance bone formation in treatment of osteoporosis and to promote bone regeneration in osteoporotic fracture healing. ..
  8. Du Y, Xiao Q, Yip H. Regulation of retinal progenitor cell differentiation by bone morphogenetic protein 4 is mediated by the smad/id cascade. Invest Ophthalmol Vis Sci. 2010;51:3764-73 pubmed publisher
    ..CONCLUSIONS. These results suggest that Id genes are one of the potential targets of BMP signaling in the differentiation of RPCs. ..