Experts and Doctors on sinoatrial node in United States


Locale: United States
Topic: sinoatrial node

Top Publications

  1. Bluemel K, Wurster R, Randall W, Duff M, O Toole M. Parasympathetic postganglionic pathways to the sinoatrial node. Am J Physiol. 1990;259:H1504-10 pubmed
    ..Attention is directed to existence of a very few synapses closer to SAN, probably in isolated ganglia immersed in fatty connective tissues along the sulcus terminalis. ..
  2. Glukhov A, Hage L, Hansen B, Pedraza Toscano A, Vargas Pinto P, Hamlin R, et al. Sinoatrial node reentry in a canine chronic left ventricular infarct model: role of intranodal fibrosis and heterogeneity of refractoriness. Circ Arrhythm Electrophysiol. 2013;6:984-94 pubmed publisher
    ..001). Both tachy- and brady-arrhythmias can result from SAN micro-reentry. Postinfarction remodeling, including increased intranodal fibrosis and heterogeneity of refractoriness, provides substrates for SAN reentry. ..
  3. Xi Moy S, Randall W, Wurster R. Nicotinic and muscarinic synaptic transmission in canine intracardiac ganglion cells innervating the sinoatrial node. J Auton Nerv Syst. 1993;42:201-13 pubmed
    ..These responses were decreased in amplitude by membrane hyperpolarization and either reversed polarity or declined to zero amplitude at about -80 mV, suggesting the inhibition of a potassium conductance. ..
  4. Singh S, Gray T, Wurster R. Nitric oxide and carbon monoxide synthesizing enzymes and soluble guanylyl cyclase within neurons of adult human cardiac ganglia. Auton Neurosci. 2009;145:93-8 pubmed publisher
    ..Our findings support the hypothesis that nitric oxide and carbon monoxide are modulators of neurotransmission in cardiac ganglia and in neural control of the adult human heart. ..
  5. Pappano A. Development of cholinergic neuroeffector transmission in the avian heart. Implications for regulatory mechanisms. Ann N Y Acad Sci. 1990;588:131-6 pubmed
    ..This suppressed response can be revealed later in life, even in adults, when provision is made to exclude Gi/Go and or K channel activity. ..
  6. Daoud E, Weiss R, Augostini R, Kalbfleisch S, Schroeder J, Polsinelli G, et al. Remodeling of sinus node function after catheter ablation of right atrial flutter. J Cardiovasc Electrophysiol. 2002;13:20-4 pubmed
    ..After ablation of persistent atrial flutter, there is temporal recovery of CSNRT and increase in spontaneous atrial activity. These findings suggest that atrial flutter induces reversible changes in sinus node function. ..
  7. Kumar P, Kusumoto F, Goldschlager N. Bradyarrhythmias in the elderly. Clin Geriatr Med. 2012;28:703-15 pubmed publisher
    ..In particular, comprehensive assessment before decisions on medical and device-based management is critical and must take into account social issues and the presence of comorbid conditions. ..
  8. Csepe T, Zhao J, Hansen B, Li N, Sul L, Lim P, et al. Human sinoatrial node structure: 3D microanatomy of sinoatrial conduction pathways. Prog Biophys Mol Biol. 2016;120:164-78 pubmed publisher
    ..Application of this integrated approach will shed new light on the role of the specialized SAN microanatomy in maintaining sinus rhythm. ..
  9. Randall D, Brown D, McGuirt A, Thompson G, Armour J, Ardell J. Interactions within the intrinsic cardiac nervous system contribute to chronotropic regulation. Am J Physiol Regul Integr Comp Physiol. 2003;285:R1066-75 pubmed

More Information


  1. Lohmeier T, Lohmeier J, Haque A, Hildebrandt D. Baroreflexes prevent neurally induced sodium retention in angiotensin hypertension. Am J Physiol Regul Integr Comp Physiol. 2000;279:R1437-48 pubmed
  2. Vong L, Bi W, O Connor Halligan K, Li C, Cserjesi P, Schwarz J. MEF2C is required for the normal allocation of cells between the ventricular and sinoatrial precursors of the primary heart field. Dev Dyn. 2006;235:1809-21 pubmed
    ..Collectively, these results suggest a fundamental role of MEF2C in ventricular cardiomyocyte differentiation and apportioning of cells between inflow and outflow precursors in the primary heart field. ..
  3. Unudurthi S, Wu X, Qian L, Amari F, Onal B, Li N, et al. Two-Pore K+ Channel TREK-1 Regulates Sinoatrial Node Membrane Excitability. J Am Heart Assoc. 2016;5:e002865 pubmed publisher
    ..These findings identify a TREK-1-dependent pathway essential for normal sinoatrial node cell excitability that serves as a potential target for selectively regulating sinoatrial node cell function. ..
  4. Mabe A, Hoover D. Structural and functional cardiac cholinergic deficits in adult neurturin knockout mice. Cardiovasc Res. 2009;82:93-9 pubmed publisher
    ..This study used nrtn knockout (KO) and wild-type (WT) mice to determine the effect of nrtn deletion on cardiac cholinergic innervation and function in the adult heart...
  5. Wolf R, Glynn P, Hashemi S, Zarei K, Mitchell C, Anderson M, et al. Atrial fibrillation and sinus node dysfunction in human ankyrin-B syndrome: a computational analysis. Am J Physiol Heart Circ Physiol. 2013;304:H1253-66 pubmed publisher
    ..Importantly, ankyrin-B dysfunction involves changes at both the cell and tissue levels that favor the common manifestation of atrial arrhythmias and SAN dysfunction. ..
  6. Rickert C, Proenza C. ParamAP: Standardized Parameterization of Sinoatrial Node Myocyte Action Potentials. Biophys J. 2017;113:765-769 pubmed publisher
    ..In conclusion, ParamAP is a powerful computational tool that facilitates quantitative analysis and enables comparison of sinoatrial APs by standardizing parameter definitions and providing an automated work flow. ..
  7. Karst M, Herron K, Olson T. X-linked nonsyndromic sinus node dysfunction and atrial fibrillation caused by emerin mutation. J Cardiovasc Electrophysiol. 2008;19:510-5 pubmed publisher
    ..Targeted genetic testing of EMD should be considered in patients with SND-associated AF and/or family history suggesting X-linked inheritance. ..
  8. Mullins M, Horowitz B, Linden D, Smith G, Norton R, Stump J. Life-threatening interaction of mibefradil and beta-blockers with dihydropyridine calcium channel blockers. JAMA. 1998;280:157-8 pubmed
    ..Physicians who are preparing to switch patients' medications from mibefradil to other antihypertensive agents should be aware of these potentially life-threatening drug-drug interactions. ..