Genomes and Genes
Experts and Doctors on signal transduction in United States
Locale: United States
Topic: signal transduction
Publications1180 found, 100 shown here
- Yin H, Chao L, Chao J. Kallikrein/kinin protects against myocardial apoptosis after ischemia/reperfusion via Akt-glycogen synthase kinase-3 and Akt-Bad.14-3-3 signaling pathways. J Biol Chem. 2005;280:8022-30 pubmed..14-3-3 signaling pathways. In conclusion, kallikrein/kinin protects against cardiomyocyte apoptosis in vivo and in vitro via Akt-Bad.14-3-3 and Akt-GSK-3beta-caspase-3 signaling pathways. ..
- Rasband M, Tayler J, Kaga Y, Yang Y, Lappe Siefke C, Nave K, et al. CNP is required for maintenance of axon-glia interactions at nodes of Ranvier in the CNS. Glia. 2005;50:86-90 pubmed..We suggest that CNP is a glial protein required for maintaining the integrity of paranodes and that disrupted axoglial signaling at this site underlies progressive axonal degeneration, observed later in the CNS of Cnp1-null mice. ..
- Li H, Wood C, Liu Y, Getchell T, Getchell M, Stromberg A. Identification of gene expression patterns using planned linear contrasts. BMC Bioinformatics. 2006;7:245 pubmed..Our method is particularly suitable for analysis of microarray experiments in which it is often difficult to take sufficiently frequent measurements and/or the sampling intervals are non-uniform. ..
- Gutzman J, Rugowski D, Nikolai S, Schuler L. Stat5 activation inhibits prolactin-induced AP-1 activity: distinct prolactin-initiated signals in tumorigenesis dependent on cell context. Oncogene. 2007;26:6341-8 pubmed..This study points to the importance of cell context in determining the spectrum of PRL-induced actions, which is critical for understanding the contributions of PRL to breast cancer. ..
- Ellacott K, Murphy J, Marks D, Cone R. Obesity-induced inflammation in white adipose tissue is attenuated by loss of melanocortin-3 receptor signaling. Endocrinology. 2007;148:6186-94 pubmed
- Chen J, Lan Y, Baek J, Gao Y, Jiang R. Wnt/beta-catenin signaling plays an essential role in activation of odontogenic mesenchyme during early tooth development. Dev Biol. 2009;334:174-85 pubmed publisher..Together, these results indicate that activation of the mesenchymal odontogenic program during early tooth development requires concerted actions of Bmp, Fgf and Wnt signaling from the presumptive dental epithelium to the mesenchyme...
- Weng T, Gao L, Bhaskaran M, Guo Y, Gou D, Narayanaperumal J, et al. Pleiotrophin regulates lung epithelial cell proliferation and differentiation during fetal lung development via beta-catenin and Dlk1. J Biol Chem. 2009;284:28021-32 pubmed publisher..These results provide evidence that pleiotrophin regulates fetal type II cell proliferation and differentiation via integration of multiple signaling pathways including pleiotrophin, beta-catenin, and Notch pathways. ..
- Hassona M, Abouelnaga Z, Elnakish M, Awad M, Alhaj M, Goldschmidt Clermont P, et al. Vascular hypertrophy-associated hypertension of profilin1 transgenic mouse model leads to functional remodeling of peripheral arteries. Am J Physiol Heart Circ Physiol. 2010;298:H2112-20 pubmed publisher..The changes in vascular responses in the mesenteric arteries of profilin1 mice are due to vascular hypertrophy and the elevation of blood pressure in the profilin1 transgenic mice. ..
- Goodman C, Miu M, Frey J, Mabrey D, Lincoln H, Ge Y, et al. A phosphatidylinositol 3-kinase/protein kinase B-independent activation of mammalian target of rapamycin signaling is sufficient to induce skeletal muscle hypertrophy. Mol Biol Cell. 2010;21:3258-68 pubmed publisher..The hypertrophic effects of Rheb are driven through a rapamycin-sensitive (RS) mechanism, mTOR is the RS element that confers the hypertrophy, and the kinase activity of mTOR is necessary for this event. ..
- Fraire Zamora J, Cardullo R. The physiological acquisition of amoeboid motility in nematode sperm: is the tail the only thing the sperm lost?. Mol Reprod Dev. 2010;77:739-50 pubmed publisher..An integrative approach to the study of nonflagellated spermatozoa will shed light on the identification of unique and conserved processes during fertilization among different taxa. ..
- Sethi N, Yan Y, Quek D, Schupbach T, Kang Y. Rabconnectin-3 is a functional regulator of mammalian Notch signaling. J Biol Chem. 2010;285:34757-64 pubmed publisher..Collectively, these findings define an important role for Rabconnectin-3 and V-ATPase activity in the Notch signaling pathway in mammalian cells. ..
- Hill B, Bhatnagar A. Protein S-glutathiolation: redox-sensitive regulation of protein function. J Mol Cell Cardiol. 2012;52:559-67 pubmed publisher..This article is part of a Special Section entitled "Post-translational Modification." ..
- Schmitt J, Smith S, Hart B, Fletcher L. CaM kinase control of AKT and LNCaP cell survival. J Cell Biochem. 2012;113:1514-26 pubmed publisher..Additionally, epinephrine promoted LNCaP cell survival through activation of AKT that was insensitive to STO-609. Taken together these data suggest a survival role for CaM KK operating through AKT and BAD in LNCaP prostate cancer cells. ..
- Zgheib C, Kurdi M, Zouein F, Gunter B, Stanley B, Zgheib J, et al. Acyloxy nitroso compounds inhibit LIF signaling in endothelial cells and cardiac myocytes: evidence that STAT3 signaling is redox-sensitive. PLoS ONE. 2012;7:e43313 pubmed publisher..These findings raise the possibility of new therapeutic strategies to target STAT3 signaling via a redox-dependent manner, particularly in the context of cardiac and non-cardiac diseases with prominent pro-inflammatory signaling. ..
- Nakanishi M, Rosenberg D. Multifaceted roles of PGE2 in inflammation and cancer. Semin Immunopathol. 2013;35:123-37 pubmed publisher..Future studies to fully understand the complex role of PGE(2) in both inflammation and cancer will be required to develop novel strategies for cancer prevention that are both effective and safe. ..
- Moore J, Miller W, Dennis M. Glucosamine induces REDD1 to suppress insulin action in retinal MÃ¼ller cells. Cell Signal. 2016;28:384-390 pubmed publisher..Overall, the findings support a model whereby GAM promotes ER stress in retinal MÃ¼ller cells, resulting in elevated REDD1 expression and thus resistance to insulin action. ..
- Jiang Z, Gest H, Bauer C. Chemosensory and photosensory perception in purple photosynthetic bacteria utilize common signal transduction components. J Bacteriol. 1997;179:5720-7 pubmed..These results indicate that eubacterial photosensory perception is mediated by light-generated signals that are transmitted through the chemotaxis signal transduction cascade...
- Turner C. Paxillin. Int J Biochem Cell Biol. 1998;30:955-9 pubmed..Since paxillin interacts with several proteins known to cause cell transformation, the binding sites for these proteins on paxillin represent potential targets for therapeutic agents. ..
- Fiedler S, Bajpai M, Carr D. Identification and characterization of RHOA-interacting proteins in bovine spermatozoa. Biol Reprod. 2008;78:184-92 pubmed..Finally, AKAP3 binding to PRKAR2 and ROPN1 is regulated by phosphorylation in vitro. ..
- Williams R, Clark S, Meyerowitz E. Genetic and physical characterization of a region of Arabidopsis chromosome 1 containing the CLAVATA1 gene. Plant Mol Biol. 1999;39:171-6 pubmed..24 kb of genomic DNA was sequenced, including a continuous stretch of 18 kb. In addition to generating clones in this region of chromosome 1, we have analyzed the size, spacing and organization of several contiguous genes. ..
- Lin T, Zeng L, Liu Y, DeFea K, Schwartz M, Chien S, et al. Rho-ROCK-LIMK-cofilin pathway regulates shear stress activation of sterol regulatory element binding proteins. Circ Res. 2003;92:1296-304 pubmed..By enhancing the SREBP-mediated cholesterol metabolism, this unique mechanism may contribute to endothelial cell functions under flow. ..
- Holder J, Haskell Luevano C. Melanocortin ligands: 30 years of structure-activity relationship (SAR) studies. Med Res Rev. 2004;24:325-56 pubmed..Herein, we discuss various SAR studies that have involved melanocortin peptides over three decades and the information these studies have provided to the melanocortin field. ..
- Zheng S, Xu W, Bose S, Banerjee A, Haque S, Erzurum S. Impaired nitric oxide synthase-2 signaling pathway in cystic fibrosis airway epithelium. Am J Physiol Lung Cell Mol Physiol. 2004;287:L374-81 pubmed..In contrast, IFN-gamma-inducible factor(s) similarly inhibit virus in CF and NL cells. Thus autocrine activation of NOS2 is defective in CF cells, but IFN-gamma induction of antiviral host defense is intact. ..
- Im H, Grass J, Johnson K, Boyer M, Wu J, Bresnick E. Measurement of protein-DNA interactions in vivo by chromatin immunoprecipitation. Methods Mol Biol. 2004;284:129-46 pubmed..Chromatin-domain scanning coupled with quantitative analysis is a powerful means of dissecting mechanisms by which signaling pathways target genes within a complex genome. ..
- Fontenot J, Rasmussen J, Gavin M, Rudensky A. A function for interleukin 2 in Foxp3-expressing regulatory T cells. Nat Immunol. 2005;6:1142-51 pubmed..Thus, IL-2 signaling seems to be critically required for maintaining the homeostasis and competitive fitness of T(reg) cells in vivo. ..
- Lee H, Ueda M, Zhu X, Perry G, Smith M. Ectopic expression of phospho-Smad2 in Alzheimer's disease: uncoupling of the transforming growth factor-beta pathway?. J Neurosci Res. 2006;84:1856-61 pubmed
- Whitmore M, Iparraguirre A, Kubelka L, Weninger W, Hai T, Williams B. Negative regulation of TLR-signaling pathways by activating transcription factor-3. J Immunol. 2007;179:3622-30 pubmed..ATF3 dysregulation merits further exploration in diseases such as type I diabetes and cancer, where altered innate immunity has been implicated in their pathogenesis. ..
- Niu W, Li Z, Zhan W, Iyer V, Marcotte E. Mechanisms of cell cycle control revealed by a systematic and quantitative overexpression screen in S. cerevisiae. PLoS Genet. 2008;4:e1000120 pubmed publisher..This work thus implicates new genes in cell cycle progression, complements previous screens, and lays the foundation for future experiments to define more precisely roles for these genes in cell cycle progression. ..
- Lopez R, Demick K, Mansfield J, Paulnock D. Type I IFNs play a role in early resistance, but subsequent susceptibility, to the African trypanosomes. J Immunol. 2008;181:4908-17 pubmed..These results show that type I IFNs play a role in early control of parasites in infected mice but may contribute to down-regulation of IFN-gamma production and subsequent loss of host resistance later in infection. ..
- Coate T, Swanson T, Copenhaver P. Reverse signaling by glycosylphosphatidylinositol-linked Manduca ephrin requires a SRC family kinase to restrict neuronal migration in vivo. J Neurosci. 2009;29:3404-18 pubmed publisher..These results support the model that MsEphrin reverse signaling induces the Src-dependent retraction of EP cell processes away from the enteric midline, thereby helping to confine the neurons to their appropriate pathways. ..
- Maksym R, Tarnowski M, Grymula K, Tarnowska J, Wysoczynski M, Liu R, et al. The role of stromal-derived factor-1--CXCR7 axis in development and cancer. Eur J Pharmacol. 2009;625:31-40 pubmed publisher..Augmenting evidence suggests that CXCR7 is involved in several aspects of tumorogenesis and could become an important target for new anti-metastatic and anti-cancer drugs. ..
- Eliasz S, Liang S, Chen Y, De Marco M, Machek O, Skucha S, et al. Notch-1 stimulates survival of lung adenocarcinoma cells during hypoxia by activating the IGF-1R pathway. Oncogene. 2010;29:2488-98 pubmed publisher..Our data provide a mechanistic explanation for Notch-1-mediated pro-survival function in hypoxic ACL tumor microenvironment. The results identify additional targets that may synergize with Notch-1 inhibition for ACL treatment. ..
- Ahluwalia M, de Groot J, Liu W, Gladson C. Targeting SRC in glioblastoma tumors and brain metastases: rationale and preclinical studies. Cancer Lett. 2010;298:139-49 pubmed publisher..The activity of these agents against solid tumors suggests that they may also be useful in treating brain metastases. This article reviews the potential for using SRC/SFK inhibitors to treat GBM and brain metastases. ..
- Wang H, Clem R. The role of IAP antagonist proteins in the core apoptosis pathway of the mosquito disease vector Aedes aegypti. Apoptosis. 2011;16:235-48 pubmed publisher..These findings demonstrate that the mechanisms by which IAP antagonists regulate apoptosis are largely conserved between A. aegypti and D. melanogaster, although subtle differences exist. ..
- Tsurumi A, Xia F, Li J, Larson K, Lafrance R, Li W. STAT is an essential activator of the zygotic genome in the early Drosophila embryo. PLoS Genet. 2011;7:e1002086 pubmed publisher..We further show that STAT92E and Zelda synergistically regulate transcription. We conclude that STAT92E, in conjunction with Zelda, plays an important role in transcription of the zygotic genome at the onset of embryonic development. ..
- Brown K, Lau J, Dom A, Witte T, Luo H, Crabtree C, et al. MG624, an ?7-nAChR antagonist, inhibits angiogenesis via the Egr-1/FGF2 pathway. Angiogenesis. 2012;15:99-114 pubmed publisher..Consequently, this process decreased FGF2 levels and angiogenesis. Our findings suggest that the anti-angiogenic effects of MG624 could be useful in anti-angiogenic therapy of human SCLCs. ..
- Li W, Laishram R, Ji Z, Barlow C, Tian B, Anderson R. Star-PAP control of BIK expression and apoptosis is regulated by nuclear PIPKI? and PKC? signaling. Mol Cell. 2012;45:25-37 pubmed publisher..This pathway is distinct from the Star-PAP-mediated oxidative stress pathway indicating signal-specific regulation of mRNA 3' end processing. ..
- Kostek M, Nagaraju K, Pistilli E, Sali A, Lai S, Gordon B, et al. IL-6 signaling blockade increases inflammation but does not affect muscle function in the mdx mouse. BMC Musculoskelet Disord. 2012;13:106 pubmed publisher..The results suggest a potential anti-inflammatory instead of the original hypothesized pro-inflammatory role of IL-6 signaling in the mdx mice. ..
- Singh D, Qi R, Jordan J, San Mateo L, Kao C. The human antimicrobial peptide LL-37, but not the mouse ortholog, mCRAMP, can stimulate signaling by poly(I:C) through a FPRL1-dependent pathway. J Biol Chem. 2013;288:8258-68 pubmed publisher..These results show that LL-37 and mCRAMP have different activities in TLR3 signaling and that LL-37 can redirect trafficking of poly(I:C) to effect signaling by TLR3 in early endosomes in a mechanism that involves FPRL1. ..
- Lai C, Ripperger J, Morella K, Jurlander J, Hawley T, Carson W, et al. Receptors for interleukin (IL)-10 and IL-6-type cytokines use similar signaling mechanisms for inducing transcription through IL-6 response elements. J Biol Chem. 1996;271:13968-75 pubmed..The data demonstrate that the IL-10R, unlike other members of the interferon receptor family, is highly effective in recruiting the signaling pathways of IL-6-type cytokine receptors. ..
- Enslen H, Tokumitsu H, Stork P, Davis R, Soderling T. Regulation of mitogen-activated protein kinases by a calcium/calmodulin-dependent protein kinase cascade. Proc Natl Acad Sci U S A. 1996;93:10803-8 pubmed..These results establish a new Ca2+-dependent mechanism for regulating MAP kinase pathways and resultant transcription. ..
- Henshall D, Araki T, Schindler C, Shinoda S, Lan J, Simon R. Expression of death-associated protein kinase and recruitment to the tumor necrosis factor signaling pathway following brief seizures. J Neurochem. 2003;86:1260-70 pubmed..In contrast, within surviving fields of the hippocampus, DAP kinase interacted with the molecular chaperone 14-3-3. These data suggest DAP kinase is involved in the molecular pathways activated during seizure-induced neuronal death. ..
- Zhang D, Schwarz E, Rosier R, Zuscik M, Puzas J, O Keefe R. ALK2 functions as a BMP type I receptor and induces Indian hedgehog in chondrocytes during skeletal development. J Bone Miner Res. 2003;18:1593-604 pubmed..The findings suggest that BMPs are integrated into the Ihh/PTHrP signaling loop and that a fine balance of BMP signaling is essential for normal chondrocyte maturation and skeletal development. ..
- Ahmer B. Cell-to-cell signalling in Escherichia coli and Salmonella enterica. Mol Microbiol. 2004;52:933-45 pubmed..The latter system has homologues in E. coli and Salmonella, as well as other bacteria, plants and animals. In fact, the protease components from Providencia and Drosophila are functionally interchangeable. ..
- Hu Y, Venkateswarlu S, Sergina N, Howell G, St Clair P, Humphrey L, et al. Reorganization of ErbB family and cell survival signaling after Knock-down of ErbB2 in colon cancer cells. J Biol Chem. 2005;280:27383-92 pubmed..Importantly, elimination of ErbB2 signaling resulted in an increase in EGFR expression and activation in transfected cells. Increased EGFR activation contributed to the sustained cell survival in transfected cells. ..
- Mei M, Su B, Harrison K, Chao M, Siedlak S, Previll L, et al. Distribution, levels and phosphorylation of Raf-1 in Alzheimer's disease. J Neurochem. 2006;99:1377-88 pubmed..Based on these findings, we speculate that Raf-1 is activated to effectively mediate Ras-dependent signals in Alzheimer's disease. ..
- McLean A, D Amour K, Jones K, Krishnamoorthy M, Kulik M, Reynolds D, et al. Activin a efficiently specifies definitive endoderm from human embryonic stem cells only when phosphatidylinositol 3-kinase signaling is suppressed. Stem Cells. 2007;25:29-38 pubmed..These findings have important implications for our understanding of hESC self-renewal and early cell fate decisions. ..
- Yang C, Zhu X, Ellison D. The thiazide-sensitive Na-Cl cotransporter is regulated by a WNK kinase signaling complex. J Clin Invest. 2007;117:3403-11 pubmed..The results provide a mechanistic explanation for the divergent effects of WT and FHHt-mutant WNK4 on NCC activity, and for the dominant nature of FHHt in humans and genetically modified mice. ..
- Klinghoffer R, Frazier J, Annis J, Berndt J, Roberts B, Arthur W, et al. A lentivirus-mediated genetic screen identifies dihydrofolate reductase (DHFR) as a modulator of beta-catenin/GSK3 signaling. PLoS ONE. 2009;4:e6892 pubmed publisher..Our data establish DHFR as a novel modulator of beta-catenin and GSK3 signaling and raise several implications for clinical use of combined methotrexate and GSK3 inhibitors as treatment for inflammatory disease. ..
- Liu J, Sun Y, Oster G, Drubin D. Mechanochemical crosstalk during endocytic vesicle formation. Curr Opin Cell Biol. 2010;22:36-43 pubmed publisher..We mainly focus on clathrin-mediated and actin-mediated endocytosis in yeast and in mammalian cells. We further speculate on how mechanochemical feedback could modulate other membrane-remodeling processes. ..
- Palczewski K. Oligomeric forms of G protein-coupled receptors (GPCRs). Trends Biochem Sci. 2010;35:595-600 pubmed publisher..Oligomerization of cell membrane receptors is fully supported by both thermodynamic calculations and the selectivity and duration of signaling required to reach targets located in various cellular compartments. ..
- Roepke T, Ronnekleiv O, Kelly M. Physiological consequences of membrane-initiated estrogen signaling in the brain. Front Biosci (Landmark Ed). 2011;16:1560-73 pubmed..This review will summarize recent findings on membrane-initiated E2 signaling in the hypothalamus and hippocampus and its contribution to the control of physiological and behavioral functions. ..
- Jenkins R, Clarke C, Canals D, Snider A, Gault C, Heffernan Stroud L, et al. Regulation of CC ligand 5/RANTES by acid sphingomyelinase and acid ceramidase. J Biol Chem. 2011;286:13292-303 pubmed publisher..Taken together, these data identify a novel role for aSMase (particularly S-SMase) in chemokine elaboration by pro-inflammatory cytokines and highlight a novel and shared function for aSMase and aCDase. ..
- Midkiff J, Borochoff Porte N, White D, Johnson D. Small molecule inhibitors of the Candida albicans budded-to-hyphal transition act through multiple signaling pathways. PLoS ONE. 2011;6:e25395 pubmed publisher..These studies are the first step in determining the target and mechanism of action of these BHT inhibitors, which may have therapeutic anti-fungal utility in the future. ..
- Piao H, Mayinger P. Growth and metabolic control of lipid signalling at the Golgi. Biochem Soc Trans. 2012;40:205-9 pubmed publisher..These results suggest that temporal and spatial integration of metabolic and lipid signalling networks at the Golgi is required for controlling the secretory pathway. ..
- Rangasamy V, Mishra R, Sondarva G, Das S, Lee T, Bakowska J, et al. Mixed-lineage kinase 3 phosphorylates prolyl-isomerase Pin1 to regulate its nuclear translocation and cellular function. Proc Natl Acad Sci U S A. 2012;109:8149-54 pubmed publisher..These findings collectively suggest that the MLK3-Pin1 signaling cascade plays a critical role in regulating the cell cycle, centrosome numbers, and oncogenesis. ..
- Mastroeni D, Chouliaras L, Grover A, Liang W, Hauns K, Rogers J, et al. Reduced RAN expression and disrupted transport between cytoplasm and nucleus; a key event in Alzheimer's disease pathophysiology. PLoS ONE. 2013;8:e53349 pubmed publisher..We propose a model in which reduced transcription regulators in the nucleus and their increased presence in the cytoplasm may lead to many of the cellular manifestations of Alzheimer's disease. ..
- Campanholle G, Mittelsteadt K, Nakagawa S, Kobayashi A, Lin S, Gharib S, et al. TLR-2/TLR-4 TREM-1 signaling pathway is dispensable in inflammatory myeloid cells during sterile kidney injury. PLoS ONE. 2013;8:e68640 pubmed publisher..To conclude, TREM-1, TLR2/4 and MyD88 signaling pathways are redundant in myeloid cell activation in kidney injury, but the latter appear to regulate activation of mesenchymal cells. ..
- Lockwood C, Huang S, Chen C, Huang Y, Xu J, Faramarzi S, et al. Decidual cell regulation of natural killer cell-recruiting chemokines: implications for the pathogenesis and prediction of preeclampsia. Am J Pathol. 2013;183:841-56 pubmed publisher..Significantly elevated IP-10 levels in first trimester sera from women eventually developing preeclampsia compared with controls, identifying IP-10 as a novel, robust early predictor of preeclampsia. ..
- Cheng C, Villani V, Buono R, Wei M, Kumar S, Yilmaz O, et al. Fasting-Mimicking Diet Promotes Ngn3-Driven β-Cell Regeneration to Reverse Diabetes. Cell. 2017;168:775-788.e12 pubmed publisher..These results indicate that a FMD promotes the reprogramming of pancreatic cells to restore insulin generation in islets from T1D patients and reverse both T1D and T2D phenotypes in mouse models. PAPERCLIP. ..
- Haun C, Roberts M, Romero M, Osburn S, Mobley C, ANDERSON R, et al. Does external pneumatic compression treatment between bouts of overreaching resistance training sessions exert differential effects on molecular signaling and performance-related variables compared to passive recovery? An exploratory study. PLoS ONE. 2017;12:e0180429 pubmed publisher..8±5.9%). EPC mitigated a reduction in flexibility and PPT that occurred with sham. Moreover, EPC reduced select skeletal muscle oxidative stress and proteolysis markers during recovery from heavy resistance exercise. ..
- Chen Y, Cantrell A, Messing R, Scheuer T, Catterall W. Specific modulation of Na+ channels in hippocampal neurons by protein kinase C epsilon. J Neurosci. 2005;25:507-13 pubmed..Overall, our data from four experimental approaches indicate that anchored PKCepsilon is the isozyme responsible for PKC-mediated reduction of peak Na+ currents in mouse hippocampal neurons. ..
- Nie J, Xue B, Sukumaran S, Jusko W, Dubois D, Almon R. Differential muscle gene expression as a function of disease progression in Goto-Kakizaki diabetic rats. Mol Cell Endocrinol. 2011;338:10-7 pubmed publisher..Furthermore, we demonstrate here the presence of chronic inflammation evident both systemically and in the musculature, despite the absence of obesity. ..
- Matsui K, Parameswaran N, Bagheri N, Willard B, Gupta N. Proteomics analysis of the ezrin interactome in B cells reveals a novel association with Myo18a?. J Proteome Res. 2011;10:3983-92 pubmed publisher..Our study is not only significant with respect to understanding the molecular regulation of BCR signaling but also provides a broader basis for understanding the mechanism of action of ezrin in other cellular systems. ..
- Paz Soldan M, Pirko I. Biogenesis and significance of central nervous system myelin. Semin Neurol. 2012;32:9-14 pubmed publisher..Understanding the pathophysiology of primary myelin disorders, and the challenges faced in treating them, is facilitated through understanding of the structure, function, and generation/regeneration of myelin. ..
- Perry D, Kitatani K, Roddy P, El Osta M, Hannun Y. Identification and characterization of protein phosphatase 2C activation by ceramide. J Lipid Res. 2012;53:1513-21 pubmed publisher..Taken together, these results show that the PP2C family of phosphatases is activated by ceramide, which may have important consequences in mediating the biological effects of ceramide. ..
- Chen X, Xia Z, Storm D. Stimulation of electro-olfactogram responses in the main olfactory epithelia by airflow depends on the type 3 adenylyl cyclase. J Neurosci. 2012;32:15769-78 pubmed publisher..We conclude that AC3 in the MOE is required for detecting the mechanical force of airflow, which in turn may regulate odorant perception during sniffing. ..
- Hackney J, Zolali Meybodi O, Cherbas P. Tissue damage disrupts developmental progression and ecdysteroid biosynthesis in Drosophila. PLoS ONE. 2012;7:e49105 pubmed publisher..Finally, we show that developmental delays induced by tissue damage are associated with decreased expression of genes involved in ecdysteroid synthesis and signaling. ..
- Shemorry A, Hwang C, Varshavsky A. Control of protein quality and stoichiometries by N-terminal acetylation and the N-end rule pathway. Mol Cell. 2013;50:540-51 pubmed publisher..This mechanistically straightforward circuit can employ the demonstrated conditionality of Ac/N-degrons to regulate subunit stoichiometries and other aspects of protein quality control. ..
- Sun W, Gaykalova D, Ochs M, Mambo E, Arnaoutakis D, Liu Y, et al. Activation of the NOTCH pathway in head and neck cancer. Cancer Res. 2014;74:1091-104 pubmed publisher..Our results imply that therapies that target the NOTCH pathway may be more widely suitable for HNSCC treatment than appreciated currently. ..
- Antebi Y, Linton J, Klumpe H, Bintu B, Gong M, Su C, et al. Combinatorial Signal Perception in the BMP Pathway. Cell. 2017;170:1184-1196.e24 pubmed publisher..Similar principles could apply to other promiscuous signaling pathways. ..
- Jordan K, Clegg N, Blasi J, Morimoto A, Sen J, Stein D, et al. The homeobox gene mirror links EGF signalling to embryonic dorso-ventral axis formation through notch activation. Nat Genet. 2000;24:429-33 pubmed
- Pircher T, Geiger J, Zhang D, Miller C, Gaines P, Wojchowski D. Integrative signaling by minimal erythropoietin receptor forms and c-Kit. J Biol Chem. 2001;276:8995-9002 pubmed..Thus, integration circuits exist in only select downstream pathways within Epo and stem call factor receptor signaling. ..
- Beauvais D, Rapraeger A. Syndecan-1-mediated cell spreading requires signaling by alphavbeta3 integrins in human breast carcinoma cells. Exp Cell Res. 2003;286:219-32 pubmed
- Chang S, Ai Y, Breyer R, Lane T, Hla T. The prostaglandin E2 receptor EP2 is required for cyclooxygenase 2-mediated mammary hyperplasia. Cancer Res. 2005;65:4496-9 pubmed..Inhibition of the EP2 pathway in the mammary gland may be a novel approach in the prevention and/or treatment of mammary cancer. ..
- Te J, Jia L, Rogers J, Miller A, Hartson S. Novel subunits of the mammalian Hsp90 signal transduction chaperone. J Proteome Res. 2007;6:1963-73 pubmed..Additionally, other new Hsp90 subunits imply that a great deal of Hsp90 function may be directed to the assembly, regulation, or exploitation of the tubulin-based cytoskeleton network, particularly the mitotic spindle. ..
- Hu B, Du Z, Li X, Ayala M, Zhang S. Human oligodendrocytes from embryonic stem cells: conserved SHH signaling networks and divergent FGF effects. Development. 2009;136:1443-52 pubmed publisher..2. Thus, despite the conservation of a similar transcriptional network across vertebrates, human stem/progenitor cells may respond differently to those of other vertebrates to certain extrinsic factors. ..
- Park S, Fung P, Nishimura N, Jensen D, Fujii H, Zhao Y, et al. Abscisic acid inhibits type 2C protein phosphatases via the PYR/PYL family of START proteins. Science. 2009;324:1068-71 pubmed publisher..Our results illustrate the power of the chemical genetic approach for sidestepping genetic redundancy. ..
- Peluso J, Liu X, Gawkowska A, Johnston MacAnanny E. Progesterone activates a progesterone receptor membrane component 1-dependent mechanism that promotes human granulosa/luteal cell survival but not progesterone secretion. J Clin Endocrinol Metab. 2009;94:2644-9 pubmed publisher..In contrast, PGRMC1 does not mediate P4's ability to acutely promote its own secretion. ..
- Wang S, Furusho M, D Sa C, Kuwada S, Conti L, Morest D, et al. Inactivation of fibroblast growth factor receptor signaling in myelinating glial cells results in significant loss of adult spiral ganglion neurons accompanied by age-related hearing impairment. J Neurosci Res. 2009;87:3428-37 pubmed publisher..Dysfunction of glial cells and FGF receptor signaling may therefore be implicated in neurodegenerative hearing loss associated with normal aging. ..
- Bauer M, Su G, Casper C, He R, Rehrauer W, Friedl A. Heterogeneity of gene expression in stromal fibroblasts of human breast carcinomas and normal breast. Oncogene. 2010;29:1732-40 pubmed publisher..Surprisingly, the variability of gene expression was slightly higher in NF than in CAF, suggesting inter-individual heterogeneity of normal stroma. ..
- Taylor W, Smith R. The role of starburst amacrine cells in visual signal processing. Vis Neurosci. 2012;29:73-81 pubmed publisher..While the role of the GABAergic transmission is well established, the role of the cholinergic transmission remains unclear. ..
- Gorbatyuk M, Shabashvili A, Chen W, Meyers C, Sullivan L, Salganik M, et al. Glucose regulated protein 78 diminishes ?-synuclein neurotoxicity in a rat model of Parkinson disease. Mol Ther. 2012;20:1327-37 pubmed publisher..Our data suggest that the molecular chaperone GRP78/BiP plays a neuroprotective role in ?-syn-induced Parkinson-like neurodegeneration. ..