Genomes and Genes
Experts and Doctors on signal transduction in Switzerland
Topic: signal transduction
Publications385 found, 100 shown here
- Ebner A, Kiefer F, Ribeiro C, Petit V, Nussbaumer U, Affolter M. Tracheal development in Drosophila melanogaster as a model system for studying the development of a branched organ. Gene. 2002;287:55-66 pubmed..We also identified a Sulfotransferase and a Multiple Inositol Polyphosphate phosphatase that are strongly upregulated in tracheal cells and discuss their possible involvement in tracheal development. ..
- Städeli R, Basler K. Dissecting nuclear Wingless signalling: recruitment of the transcriptional co-activator Pygopus by a chain of adaptor proteins. Mech Dev. 2005;122:1171-82 pubmed..Together, our results suggest that the transcriptional output of Wg pathway activity largely relies on a 'chain of adaptors' design to direct the Pygo NHD to Wg target promoters in an Arm-dependent manner. ..
- Glauser D, Schlegel W. The FoxO/Bcl-6/cyclin D2 pathway mediates metabolic and growth factor stimulation of proliferation in Min6 pancreatic beta-cells. J Recept Signal Transduct Res. 2009;29:293-8 pubmed publisher..Thus, in pancreatic beta-cells, the FoxO/Bcl6/cyclin D2 pathway connects nutrient and growth factor status to cell cycle control, and may therefore be considered for its therapeutic potential in diabetes. ..
- Hafen E. Patterning by cell recruitment in the Drosophila eye. Curr Opin Genet Dev. 1991;1:268-74 pubmed..Recent molecular genetic characterization of these interactions in Drosophila and some emerging principles of how cell fate is determined in this system are the subject of this review. ..
- Fehr T, Rickert R, Odermatt B, Roes J, Rajewsky K, Hengartner H, et al. Antiviral protection and germinal center formation, but impaired B cell memory in the absence of CD19. J Exp Med. 1998;188:145-55 pubmed..Thus, our study confirms a costimulatory role of CD19 on B cells under limiting antigen conditions and indicates an important role for B cell memory. ..
- Schaerer M, Kannenberg K, Hunziker P, Baumann S, Sigel E. Interaction between GABA(A) receptor beta subunits and the multifunctional protein gC1q-R. J Biol Chem. 2001;276:26597-604 pubmed..Our observations therefore suggest a tight interaction between gC1q-R and the GABA(A) receptor which might be involved in receptor biosynthesis or modulation of the mature function. ..
- Greber U. Signalling in viral entry. Cell Mol Life Sci. 2002;59:608-26 pubmed..This review illustrates that multiple activation of host cells during viral entry profoundly impacts the elaborate relationship between hosts and viral pathogens. ..
- VAN DER GOOT F, Tran van Nhieu G, Allaoui A, Sansonetti P, Lafont F. Rafts can trigger contact-mediated secretion of bacterial effectors via a lipid-based mechanism. J Biol Chem. 2004;279:47792-8 pubmed..Altogether, these data indicate that specific lipid packing can trigger contact-mediated secretion by S. flexneri. ..
- Gajendran N, Kapfhammer J, Lain E, Canepari M, Vogt K, Wisden W, et al. Neuregulin signaling is dispensable for NMDA- and GABA(A)-receptor expression in the cerebellum in vivo. J Neurosci. 2009;29:2404-13 pubmed publisher..We conclude that NRG/ErbB signaling to the granule cells is dispensable for the normal development of their synaptic inputs. ..
- Schmitz N, Beerli R, Bauer M, Jegerlehner A, Dietmeier K, Maudrich M, et al. Universal vaccine against influenza virus: linking TLR signaling to anti-viral protection. Eur J Immunol. 2012;42:863-9 pubmed publisher..Hence, the innate immune system is required to direct isotype switching toward the more protective IgG2a/c antibodies...
- Hohm T, Preuten T, Fankhauser C. Phototropism: translating light into directional growth. Am J Bot. 2013;100:47-59 pubmed publisher..In this review, we discuss the major steps leading from light perception to directional growth concentrating on Arabidopsis. In addition, we highlight links that connect these different steps enabling the phototropic response. ..
- Z hringer F, Lacanna E, Jenal U, Schirmer T, Boehm A. Structure and signaling mechanism of a zinc-sensory diguanylate cyclase. Structure. 2013;21:1149-57 pubmed publisher..The study outlines the structural principles of this zinc sensor. Zinc binding seems to regulate the activity of the catalytic GGDEF domains by impeding their mobility and thus preventing productive encounter of the two GTP substrates...
- Castets P, RÃ¼egg M. MTORC1 determines autophagy through ULK1 regulation in skeletal muscle. Autophagy. 2013;9:1435-7 pubmed publisher..In conclusion, MTORC1 constitutes the master regulator of autophagy induction in skeletal muscle and its deregulation leads to pathologic alterations of muscle homeostasis. ..
- Maskey D, Yousefi S, Schmid I, Zlobec I, Perren A, Friis R, et al. ATG5 is induced by DNA-damaging agents and promotes mitotic catastrophe independent of autophagy. Nat Commun. 2013;4:2130 pubmed publisher..Our data suggest a dual role for ATG5 in response to drug-induced DNA damage, where it acts in two signalling pathways in two distinct cellular compartments, the cytosol and the nucleus. ..
- Aubry J, Schwald M, Ballmann E, Karege F. Early effects of mood stabilizers on the Akt/GSK-3beta signaling pathway and on cell survival and proliferation. Psychopharmacology (Berl). 2009;205:419-29 pubmed publisher..The other medications have no effect. The study shows the importance of the Akt/GSK-3 axis in MS actions but also pinpoints a different dependence of these drugs on this signaling axis. ..
- Kania G, Blyszczuk P, Stein S, Valaperti A, Germano D, Dirnhofer S, et al. Heart-infiltrating prominin-1+/CD133+ progenitor cells represent the cellular source of transforming growth factor beta-mediated cardiac fibrosis in experimental autoimmune myocarditis. Circ Res. 2009;105:462-70 pubmed publisher..Recognizing the critical, cytokine-dependent role of bone marrow-derived progenitors in cardiac remodeling might result in novel treatment concepts against inflammatory heart failure. ..
- Bessa J, Kopf M, Bachmann M. Cutting edge: IL-21 and TLR signaling regulate germinal center responses in a B cell-intrinsic manner. J Immunol. 2010;184:4615-9 pubmed publisher..Hence, IL-21 acts directly on B cells and cooperates with TLR signaling for optimal B cell responses. ..
- Liu Y, KÃ¤ch A, Ziegler U, Ong A, Wallace D, Arcaro A, et al. The role of phospholipase D in modulating the MTOR signaling pathway in polycystic kidney disease. PLoS ONE. 2013;8:e73173 pubmed publisher..Targeting PLD isoforms with pharmacological inhibitors may represent a new therapeutic strategy in PKD. ..
- Drogen F, O Rourke S, Stucke V, Jaquenoud M, Neiman A, Peter M. Phosphorylation of the MEKK Ste11p by the PAK-like kinase Ste20p is required for MAP kinase signaling in vivo. Curr Biol. 2000;10:630-9 pubmed..This mechanism may serve as a paradigm for the activation of mammalian MEKKs. ..
- Kataoka T, Budd R, Holler N, Thome M, Martinon F, Irmler M, et al. The caspase-8 inhibitor FLIP promotes activation of NF-kappaB and Erk signaling pathways. Curr Biol. 2000;10:640-8 pubmed
- Burns K, Clatworthy J, Martin L, Martinon F, Plumpton C, Maschera B, et al. Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor. Nat Cell Biol. 2000;2:346-51 pubmed..As overexpression of Tollip results in impaired NF-kappaB activation, we conclude that Tollip is an important constituent of the IL-1R signalling pathway. ..
- Thorens B. GLUT2 in pancreatic and extra-pancreatic gluco-detection (review). Mol Membr Biol. 2001;18:265-73 pubmed..These studies may pave the way to a fine dissection of the molecular and cellular components of extra-pancreatic glucose sensors involved in the control of glucose and energy homeostasis. ..
- Crespo J, Hall M. Elucidating TOR signaling and rapamycin action: lessons from Saccharomyces cerevisiae. Microbiol Mol Biol Rev. 2002;66:579-91, table of contents pubmed..The current understanding of TOR and rapamycin is derived largely from studies with S. cerevisiae. In this review, we discuss the contributions made by S. cerevisiae to understanding rapamycin action and TOR function. ..
- Scandella E, Men Y, Legler D, Gillessen S, Prikler L, Ludewig B, et al. CCL19/CCL21-triggered signal transduction and migration of dendritic cells requires prostaglandin E2. Blood. 2004;103:1595-601 pubmed..Hence, our data provide insight into CCL19/CCL21-triggered signal transduction pathways and identify a novel function for PGE2 in controlling the migration of mature MoDCs by facilitating CCR7 signal transduction. ..
- Pyrowolakis G, Hartmann B, Muller B, Basler K, Affolter M. A simple molecular complex mediates widespread BMP-induced repression during Drosophila development. Dev Cell. 2004;7:229-40 pubmed
- Di Cara A, Garg A, De Micheli G, Xenarios I, Mendoza L. Dynamic simulation of regulatory networks using SQUAD. BMC Bioinformatics. 2007;8:462 pubmed..SQUAD provides a user-friendly graphical interface, accessible to both computational and experimental biologists for the fast qualitative simulation of large regulatory networks for which kinetic data is not necessarily available. ..
- Thelen M, Stein J. How chemokines invite leukocytes to dance. Nat Immunol. 2008;9:953-9 pubmed publisher..In particular, we discuss the potential influences of the formation of oligomers of ligand and receptor and of coupling between chemokine signals and regulators of the cytoskeleton, such as small GTPases. ..
- Chera S, Ghila L, Dobretz K, Wenger Y, Bauer C, Buzgariu W, et al. Apoptotic cells provide an unexpected source of Wnt3 signaling to drive hydra head regeneration. Dev Cell. 2009;17:279-89 pubmed publisher..We propose that different types of injuries induce distinct cellular modes of Hydra head regeneration, which nonetheless converge on a central effector, Wnt3...
- Hynes N, Stoelzle T. Key signalling nodes in mammary gland development and cancer: Myc. Breast Cancer Res. 2009;11:210 pubmed publisher..This review will concentrate on Myc as a signaling mediator in the mammary gland, discussing its regulation and function during normal development, as well as its activation and roles in breast cancer...
- Kramer I, Halleux C, Keller H, Pegurri M, Gooi J, Weber P, et al. Osteocyte Wnt/beta-catenin signaling is required for normal bone homeostasis. Mol Cell Biol. 2010;30:3071-85 pubmed publisher..Together, these results reveal a crucial novel function for osteocyte beta-catenin signaling in controlling bone homeostasis. ..
- Cornils A, Gloeck M, Chen Z, Zhang Y, Alcedo J. Specific insulin-like peptides encode sensory information to regulate distinct developmental processes. Development. 2011;138:1183-93 pubmed publisher..Together, our data suggest that specific ILPs generate precise responses to dauer-inducing cues, such as pheromones and low food levels, to control development through stimulus-regulated expression in different neurons. ..
- Stute P, Sielker S, Wood C, Register T, Lees C, Dewi F, et al. Life stage differences in mammary gland gene expression profile in non-human primates. Breast Cancer Res Treat. 2012;133:617-34 pubmed publisher..Several of the pathways activated during pubertal development have been implicated in cancer development and metastasis, supporting the idea that other developmental markers may have application as biomarkers for BC. ..
- Gross O, Yazdi A, Thomas C, Masin M, Heinz L, Guarda G, et al. Inflammasome activators induce interleukin-1? secretion via distinct pathways with differential requirement for the protease function of caspase-1. Immunity. 2012;36:388-400 pubmed publisher..Because inflammasomes contribute to the pathology of numerous chronic inflammatory diseases such as gout and diabetes, IL-1? antagonists may be beneficial in the treatment of these disorders. ..
- ..We also discuss how adenoviruses use acto-myosin, integrins or microtubule-based kinesin motors for reverse signalling to facilitate their stepwise uncoating programme. ..
- Mair F, Joller S, Hoeppli R, Onder L, Hahn M, Ludewig B, et al. The NFÎºB-inducing kinase is essential for the developmental programming of skin-resident and IL-17-producing Î³Î´ T cells. elife. 2015;4: pubmed publisher..Using a novel conditional mutant of NIK, we could show in vivo that NIK signaling in thymic epithelial cells is essential for the thymic hardwiring of Î³Î´ T cell cytokine production. ..
- Barbet N, Schneider U, Helliwell S, Stansfield I, Tuite M, Hall M. TOR controls translation initiation and early G1 progression in yeast. Mol Biol Cell. 1996;7:25-42 pubmed..Such a pathway may constitute a checkpoint that prevents early G1 progression and growth in the absence of nutrients. ..
- Antonsson B, Lutjens R, Di Paolo G, Kassel D, Allet B, Bernard A, et al. Purification, characterization, and in vitro phosphorylation of the neuron-specific membrane-associated protein SCG10. Protein Expr Purif. 1997;9:363-71 pubmed..Our data suggest that SCG10 is a phosphoprotein which might be involved in signal transduction in neurons. ..
- Affolter M, Mann R. Development. Legs, eyes, or wings--selectors and signals make the difference. Science. 2001;292:1080-1 pubmed
- Felix G, Boller T. Molecular sensing of bacteria in plants. The highly conserved RNA-binding motif RNP-1 of bacterial cold shock proteins is recognized as an elicitor signal in tobacco. J Biol Chem. 2003;278:6201-8 pubmed..Thus, the CSP domain containing the RNP-1 motif provides a structure characteristic for bacteria in general, and tobacco plants have evolved a highly sensitive chemoperception system to detect this bacterial PAMP. ..
- Garcin D, Marq J, Goodbourn S, Kolakofsky D. The amino-terminal extensions of the longer Sendai virus C proteins modulate pY701-Stat1 and bulk Stat1 levels independently of interferon signaling. J Virol. 2003;77:2321-9 pubmed..The actions of the SeV C proteins in counteracting the cellular antiviral response are clearly more extensive than previously appreciated. ..
- Azzi A, Gysin R, Kempna P, Ricciarelli R, Villacorta L, Visarius T, et al. The role of alpha-tocopherol in preventing disease: from epidemiology to molecular events. Mol Aspects Med. 2003;24:325-36 pubmed..Rather, it would be important to protect vitamin E through a network of cellular antioxidant defences, similarly to what occurs with proteins, nucleic acids and lipids. ..
- Cobas M, Wilson A, Ernst B, Mancini S, MacDonald H, Kemler R, et al. Beta-catenin is dispensable for hematopoiesis and lymphopoiesis. J Exp Med. 2004;199:221-9 pubmed..In contrast to earlier reports, these data exclude an essential role for beta-catenin during hematopoiesis and lymphopoiesis. ..
- Porcellini S, Traggiai E, Schenk U, Ferrera D, Matteoli M, Lanzavecchia A, et al. Regulation of peripheral T cell activation by calreticulin. J Exp Med. 2006;203:461-71 pubmed..These observations support the hypothesis that CRT-dependent shaping of Ca2+ signaling critically contributes to the modulation of the T cell adaptive immune response. ..
- Bonaventure G, Gfeller A, Proebsting W, Hortensteiner S, Chételat A, Martinoia E, et al. A gain-of-function allele of TPC1 activates oxylipin biogenesis after leaf wounding in Arabidopsis. Plant J. 2007;49:889-98 pubmed..The results indicate that cation fluxes exert strong control over the positive feedback loop whereby JA stimulates its own synthesis. ..
- Michalik L, Wahli W. Guiding ligands to nuclear receptors. Cell. 2007;129:649-51 pubmed..Remarkably, retinoic acid signaling through RAR or PPARbeta/delta-which depends on cytoplasmic retinoic acid transporters-commits the cell to opposite fates, apoptosis or survival, respectively. ..
- Repici M, Centeno C, Tomasi S, Forloni G, Bonny C, Vercelli A, et al. Time-course of c-Jun N-terminal kinase activation after cerebral ischemia and effect of D-JNKI1 on c-Jun and caspase-3 activation. Neuroscience. 2007;150:40-9 pubmed
- Hardtke C. Transcriptional auxin-brassinosteroid crosstalk: who's talking?. Bioessays. 2007;29:1115-23 pubmed..This article reviews the evidence for transcriptional crosstalk between auxin and brassinosteroid and its molecular basis. ..
- Banziger Tobler N, Halin C, Kajiya K, Detmar M. Growth hormone promotes lymphangiogenesis. Am J Pathol. 2008;173:586-97 pubmed publisher..These results identify growth hormone as a novel lymphangiogenic factor. ..
- van der Loo B, Schildknecht S, Zee R, Bachschmid M. Signalling processes in endothelial ageing in relation to chronic oxidative stress and their potential therapeutic implications in humans. Exp Physiol. 2009;94:305-10 pubmed publisher..A model linking .NO, mitochondria, MnSOD and its acetylation/deacetylation by sirtuins (NAD+-dependent class III histone deacetylases) may be the basis for a potentially new powerful therapeutic intervention in the ageing process. ..
- Grünewald F, Prota A, Giese A, Ballmer Hofer K. Structure-function analysis of VEGF receptor activation and the role of coreceptors in angiogenic signaling. Biochim Biophys Acta. 2010;1804:567-80 pubmed publisher..Here we discuss the structural features of VEGF family ligands and their receptors in relation to their distinct signal output and angiogenic potential. ..
- Cescato R, Loesch K, Waser B, Mäcke H, Rivier J, Reubi J, et al. Agonist-biased signaling at the sst2A receptor: the multi-somatostatin analogs KE108 and SOM230 activate and antagonize distinct signaling pathways. Mol Endocrinol. 2010;24:240-9 pubmed publisher..Thus, SOM230 and KE108 are not somatostatin mimics, and their functional selectivity at sst2A receptors must be considered in clinical applications where it may have important consequences for therapy. ..
- Herzog D, Loetscher P, van Hengel J, Knüsel S, Brakebusch C, Taylor V, et al. The small GTPase RhoA is required to maintain spinal cord neuroepithelium organization and the neural stem cell pool. J Neurosci. 2011;31:5120-30 pubmed publisher..Together, our data show that RhoA signaling is necessary for AJ regulation and for the maintenance of mammalian neuroepithelium organization preventing precocious cell-cycle exit and differentiation. ..
- Jungel A, Distler J, Gay S, Distler O. Epigenetic modifications: novel therapeutic strategies for systemic sclerosis?. Expert Rev Clin Immunol. 2011;7:475-80 pubmed publisher..In vitro and in vivo experiments demonstrate that the use of epigenetic-based drugs on these cells is able to reverse their activated phenotype. ..
- Breitling J, Aebi M. N-linked protein glycosylation in the endoplasmic reticulum. Cold Spring Harb Perspect Biol. 2013;5:a013359 pubmed publisher..This article focuses on the processes in the ER. Based on the highly conserved nature of this pathway we concentrate on the mechanisms in the eukaryotic model organism Saccharomyces cerevisiae. ..
- da Palma J, Cendron L, Seidah N, Pasquato A, Kunz S. Mechanism of Folding and Activation of Subtilisin Kexin Isozyme-1 (SKI-1)/Site-1 Protease (S1P). J Biol Chem. 2016;291:2055-66 pubmed publisher..The BC region appears as a later evolutionary acquisition, possibly allowing more subtle fine-tuning of the maturation process. ..
- Castiglia V, Piersigilli A, Ebner F, Janos M, Goldmann O, DambÃ¶ck U, et al. Type I Interferon Signaling Prevents IL-1Î²-Driven Lethal Systemic Hyperinflammation during Invasive Bacterial Infection of Soft Tissue. Cell Host Microbe. 2016;19:375-87 pubmed publisher..pyogenes 23S rRNA in an Irf5-dependent manner. Our study establishes IL-1Î² and IFN-I levels as key homeostatic variables of protective, yet tuned, immune responses against severe invasive bacterial infection. ..
- Reinders A, Bürckert N, Boller T, Wiemken A, De Virgilio C. Saccharomyces cerevisiae cAMP-dependent protein kinase controls entry into stationary phase through the Rim15p protein kinase. Genes Dev. 1998;12:2943-55 pubmed..Taken together, these results place Rim15p immediately downstream and under negative control of cAPK and define a positive regulatory role of Rim15p for entry into both meiosis and stationary phase. ..
- Foti M, Cartier L, Piguet V, Lew D, Carpentier J, Trono D, et al. The HIV Nef protein alters Ca(2+) signaling in myelomonocytic cells through SH3-mediated protein-protein interactions. J Biol Chem. 1999;274:34765-72 pubmed..Collectively, our results demonstrate that the human immunodeficiency virus 1 Nef protein manipulates intracellular Ca(2+) stores through SH3-mediated interactions in myelomonocytic cells. ..
- Raposinho P, Castillo E, d Alleves V, Broqua P, Pralong F, Aubert M. Chronic blockade of the melanocortin 4 receptor subtype leads to obesity independently of neuropeptide Y action, with no adverse effects on the gonadotropic and somatotropic axes. Endocrinology. 2000;141:4419-27 pubmed..In this situation NPY probably acted both by exacerbating food intake through Y receptors and by reducing the satiety signal driven by MC peptides. ..
- Methot N, Basler K. An absolute requirement for Cubitus interruptus in Hedgehog signaling. Development. 2001;128:733-42 pubmed
- Martin D, Brown Luedi M, Chiquet Ehrismann R. Tenascin-C signaling through induction of 14-3-3 tau. J Cell Biol. 2003;160:171-5 pubmed..Therefore, we postulate that tenascin-C promotes the growth of tumor cells by causing an increase in the expression of 14-3-3 tau, which in turn has a positive effect on tumor cell adhesion and growth. ..
- Maedler K, Sergeev P, Ehses J, Mathe Z, Bosco D, Berney T, et al. Leptin modulates beta cell expression of IL-1 receptor antagonist and release of IL-1beta in human islets. Proc Natl Acad Sci U S A. 2004;101:8138-43 pubmed..Moreover, siIL-1Ra enhanced glucose-induced beta cell apoptosis. These findings demonstrate expression of IL-1Ra in the human beta cell, providing localized protection against leptin- and glucose-induced islet IL-1beta. ..
- Meyer M, Haas E, Barton M. Gender differences of cardiovascular disease: new perspectives for estrogen receptor signaling. Hypertension. 2006;47:1019-26 pubmed
- Zipfel C, Kunze G, Chinchilla D, Caniard A, Jones J, Boller T, et al. Perception of the bacterial PAMP EF-Tu by the receptor EFR restricts Agrobacterium-mediated transformation. Cell. 2006;125:749-60 pubmed..These results demonstrate that EFR is the EF-Tu receptor and that plant defense responses induced by PAMPs such as EF-Tu reduce transformation by Agrobacterium. ..
- Bossen C, Schneider P. BAFF, APRIL and their receptors: structure, function and signaling. Semin Immunol. 2006;18:263-75 pubmed..Very little is known about other signaling events associated with receptor engagement by BAFF and APRIL that lead for example to B cell activation or to CD40L-independent Ig switch. ..
- Dummler B, Tschopp O, Hynx D, Yang Z, Dirnhofer S, Hemmings B. Life with a single isoform of Akt: mice lacking Akt2 and Akt3 are viable but display impaired glucose homeostasis and growth deficiencies. Mol Cell Biol. 2006;26:8042-51 pubmed
- Puklin Faucher E, Gao M, Schulten K, Vogel V. How the headpiece hinge angle is opened: New insights into the dynamics of integrin activation. J Cell Biol. 2006;175:349-60 pubmed..Finally, we show with steered MD how force accelerates hinge-angle opening along the same allosteric pathway. Together with available experimental data, these predictions provide a novel framework for understanding integrin activation. ..
- Brisbare Roch C, Dingemanse J, Koberstein R, Hoever P, Aissaoui H, Flores S, et al. Promotion of sleep by targeting the orexin system in rats, dogs and humans. Nat Med. 2007;13:150-5 pubmed..No signs of cataplexy were observed, in contrast to the rodent, dog or human narcolepsy syndromes. These results open new perspectives for investigating the role of endogenous orexins in sleep-wake regulation. ..
- Nombela Arrieta C, Mempel T, Soriano S, Mazo I, Wymann M, Hirsch E, et al. A central role for DOCK2 during interstitial lymphocyte motility and sphingosine-1-phosphate-mediated egress. J Exp Med. 2007;204:497-510 pubmed..In summary, our data support a central role for DOCK2, and to a lesser extent T cell-expressed PI3Kgamma, for signal transduction during interstitial lymphocyte migration and S1P-mediated egress. ..
- Meyer U, Murray P, Urwyler A, Yee B, Schedlowski M, Feldon J. Adult behavioral and pharmacological dysfunctions following disruption of the fetal brain balance between pro-inflammatory and IL-10-mediated anti-inflammatory signaling. Mol Psychiatry. 2008;13:208-21 pubmed..Hence, shifts of the balance between pro- and anti-inflammatory cytokine classes may be a critical determinant of the final impact on neurodevelopment following early life infection or innate immune imbalances. ..
- Auderset F, Schuster S, Coutaz M, Koch U, Desgranges F, Merck E, et al. Redundant Notch1 and Notch2 signaling is necessary for IFN? secretion by T helper 1 cells during infection with Leishmania major. PLoS Pathog. 2012;8:e1002560 pubmed publisher..Collectively, we demonstrate here a crucial role for RBP-J?-independent Notch signaling in the differentiation of a functional Th1 immune response following L. major infection...
- Boyman O, Kolios A, Raeber M. Modulation of T cell responses by IL-2 and IL-2 complexes. Clin Exp Rheumatol. 2015;33:S54-7 pubmed..This article discusses the properties and clinical implications of IL-2 and IL-2 complexes. ..
- Scholz G, Jandus C, Zhang L, GrandclÃ©ment C, Lopez Mejia I, Soneson C, et al. Modulation of mTOR Signalling Triggers the Formation of Stem Cell-like Memory T Cells. EBioMedicine. 2016;4:50-61 pubmed publisher..Our data identify a mechanism of pharmacological mTORC1 inhibitors, allowing us to confer stemness to human naive T cells which may be significantly relevant for the design of innovative T cell-based cancer immunotherapies. ..
- Jiang K, Rezabkova L, Hua S, Liu Q, Capitani G, Altelaar A, et al. Microtubule minus-end regulation at spindle poles by an ASPM-katanin complex. Nat Cell Biol. 2017;19:480-492 pubmed publisher..We propose that the ASPM-katanin complex controls microtubule disassembly at spindle poles and that misregulation of this process can lead to microcephaly. ..
- Campbell K, Giorda R. The cytoplasmic domain of rat NKR-P1 receptor interacts with the N-terminal domain of p56(lck) via cysteine residues. Eur J Immunol. 1997;27:72-7 pubmed..This could reflect a higher activation threshold for the NKR-P1 and CD8 receptors, which are involved in cytolytic responses, compared to CD4 which is involved in T cell helper function. ..
- Degermann S, Sollami G, Karjalainen K. Impaired NK1.1 T cell development in mice transgenic for a T cell receptor beta chain lacking the large, solvent-exposed cbeta FG loop. J Exp Med. 1999;190:1357-62 pubmed..Development of NK1.1 T cells appears to need a TCR-beta conformation dependent on the presence of the Cbeta loop that is not necessarily required for assembly and function of TCRs on most alpha/beta T cells. ..
- Gomez Gomez L, Bauer Z, Boller T. Both the extracellular leucine-rich repeat domain and the kinase activity of FSL2 are required for flagellin binding and signaling in Arabidopsis. Plant Cell. 2001;13:1155-63 pubmed..These results suggest that KAPP functions as a negative regulator of the FLS2 signal transduction pathway and that the phosphorylation of FLS2 is necessary for proper binding and signaling of the flagellin receptor complex. ..
- Heussler V, Küenzi P, Fraga F, Schwab R, Hemmings B, Dobbelaere D. The Akt/PKB pathway is constitutively activated in Theileria-transformed leucocytes, but does not directly control constitutive NF-kappaB activation. Cell Microbiol. 2001;3:537-50 pubmed..We also demonstrate that Akt/PKB contributes, at least in part, to the proliferation of Theileria-transformed T cells...
- Stump G, Durrer A, Klein A, Lütolf S, Suter U, Taylor V. Notch1 and its ligands Delta-like and Jagged are expressed and active in distinct cell populations in the postnatal mouse brain. Mech Dev. 2002;114:153-9 pubmed..The distribution of Notch1 and its putative ligands suggest distinct roles in specific subsets of cells in the postnatal brain including putative stem cells and differentiated neurons. ..
- Affolter M, Weijer C. Signaling to cytoskeletal dynamics during chemotaxis. Dev Cell. 2005;9:19-34 pubmed..We compare and contrast these insights with our current understanding of pathways controlling chemotactic movements in more-complex multicellular developmental contexts. ..
- Dessimoz J, Bonnard C, Huelsken J, Grapin Botton A. Pancreas-specific deletion of beta-catenin reveals Wnt-dependent and Wnt-independent functions during development. Curr Biol. 2005;15:1677-83 pubmed..These effects are likely to be due to the function of beta-catenin at the membrane. Mice later recover from pancreatitis and regenerate normal pancreas and duodenal villi from the wild-type (wt) cells that escape beta-catenin deletion. ..
- Oskarsson T, Essers M, Dubois N, Offner S, Dubey C, Roger C, et al. Skin epidermis lacking the c-Myc gene is resistant to Ras-driven tumorigenesis but can reacquire sensitivity upon additional loss of the p21Cip1 gene. Genes Dev. 2006;20:2024-9 pubmed..This identifies c-Myc-mediated repression of p21(Cip1) as a key step for Ras-driven epidermal tumorigenesis. ..
- Chera S, Kaloulis K, Galliot B. The cAMP response element binding protein (CREB) as an integrative HUB selector in metazoans: clues from the hydra model system. Biosystems. 2007;87:191-203 pubmed
- Besseyrias V, Fiorini E, Strobl L, Zimber Strobl U, Dumortier A, Koch U, et al. Hierarchy of Notch-Delta interactions promoting T cell lineage commitment and maturation. J Exp Med. 2007;204:331-43 pubmed..Collectively, our results establish a hierarchy of Notch-Delta interactions in which N1-DL4 exhibits the greatest capacity to induce and support T cell development. ..
- Bedu E, Desplanches D, Pequignot J, Bordier B, Desvergne B. Double gene deletion reveals the lack of cooperation between PPARalpha and PPARbeta in skeletal muscle. Biochem Biophys Res Commun. 2007;357:877-81 pubmed..In conclusion, PPARbeta is not required for maintaining skeletal muscle metabolic activity and does not compensate the lack of PPARalpha in PPARalpha null mice. ..
- Bachmann M, Wolint P, Walton S, Schwarz K, Oxenius A. Differential role of IL-2R signaling for CD8+ T cell responses in acute and chronic viral infections. Eur J Immunol. 2007;37:1502-12 pubmed..Thus, depending on the chronicity of antigen exposure, IL-2R signaling is either essential or largely dispensable for induction and maintenance of virus-specific CD8+ T cell responses. ..
- Fevr T, Robine S, Louvard D, Huelsken J. Wnt/beta-catenin is essential for intestinal homeostasis and maintenance of intestinal stem cells. Mol Cell Biol. 2007;27:7551-9 pubmed..This challenges attempts to target aberrant Wnt signaling as a new therapeutic strategy to treat colorectal cancer. ..