Genomes and Genes
Experts and Doctors on signal transduction in Germany
Topic: signal transduction
Publications563 found, 100 shown here
- Siess W. Platelet interaction with bioactive lipids formed by mild oxidation of low-density lipoprotein. Pathophysiol Haemost Thromb. 2006;35:292-304 pubmed..LPA-mediated platelet activation might contribute to arterial thrombus formation after rupture of atherosclerotic plaques and to the increased blood thrombogenicity of patients with cardiovascular diseases. ..
- Schweiger D, Furstenberger G, Krieg P. Inducible expression of 15-lipoxygenase-2 and 8-lipoxygenase inhibits cell growth via common signaling pathways. J Lipid Res. 2007;48:553-64 pubmed..Our data suggest that 15-LOX-2 and 8-LOX, although displaying different positional specificity, may use common signaling pathways to induce growth inhibition in premalignant epithelial cells. ..
- Sargin B, Choudhary C, Crosetto N, Schmidt M, Grundler R, Rensinghoff M, et al. Flt3-dependent transformation by inactivating c-Cbl mutations in AML. Blood. 2007;110:1004-12 pubmed..Our results indicate an important role of Cbl proteins in Flt3 signal modulation. Also, the data suggest a novel mechanism of leukemic transformation in AML by mutational inactivation of negative RTK regulators. ..
- Schweda F, Friis U, Wagner C, Skott O, Kurtz A. Renin release. Physiology (Bethesda). 2007;22:310-9 pubmed..The unravelling of these mysteries has led to new and interesting insights into the process of renin release. ..
- Commichau F, Stülke J. Trigger enzymes: bifunctional proteins active in metabolism and in controlling gene expression. Mol Microbiol. 2008;67:692-702 pubmed..An analysis of the occurrence of trigger enzymes suggests that the duplication and subsequent functional specialization is a major pattern in their evolution. ..
- Herold S, Hock A, Herkert B, Berns K, Mullenders J, Beijersbergen R, et al. Miz1 and HectH9 regulate the stability of the checkpoint protein, TopBP1. EMBO J. 2008;27:2851-61 pubmed publisher..Our data show that Miz1 and Myc affect the activity of the Atr checkpoint through their effect on TopBP1 chromatin association and stability. ..
- Maeurer C, Holland S, Pierre S, Potstada W, Scholich K. Sphingosine-1-phosphate induced mTOR-activation is mediated by the E3-ubiquitin ligase PAM. Cell Signal. 2009;21:293-300 pubmed publisher..In conclusion we show that PAM is a novel regulator of the mTOR pathway and that PAM may directly activate Rheb as a guanosine exchange factor (GEF). ..
- Schermer B, Benzing T. Lipid-protein interactions along the slit diaphragm of podocytes. J Am Soc Nephrol. 2009;20:473-8 pubmed publisher..The finding that cholesterol interaction regulates the activity of ion channels at the glomerular filtration barrier has important implications for renal physiology and pathophysiology. ..
- Schmidt A, Koch P. Desmosomes: just cell adhesion or is there more?. Cell Adh Migr. 2007;1:28-32 pubmed..Furthermore, there is evidence to suggest that abnormal signaling through these junctions contributes to the symptoms of certain skin and heart diseases. ..
- Messlik A, Schmechel S, Kisling S, Bereswill S, Heimesaat M, Fischer A, et al. Loss of Toll-like receptor 2 and 4 leads to differential induction of endoplasmic reticulum stress and proapoptotic responses in the intestinal epithelium under conditions of chronic inflammation. J Proteome Res. 2009;8:4406-17 pubmed publisher..We hypothesize that ER stress-associated processes in the absence of TLR2 and TLR4 differentially affect host responses and epithelial functions under conditions of genetically driven chronic intestinal inflammation. ..
- Hägele H, Allam R, Pawar R, Reichel C, Krombach F, Anders H. Double-stranded DNA activates glomerular endothelial cells and enhances albumin permeability via a toll-like receptor-independent cytosolic DNA recognition pathway. Am J Pathol. 2009;175:1896-904 pubmed publisher..This innate antiviral response program suggests a novel pathomechanism regulating DNA virus-mediated induction or aggravation of glomerulonephritis. ..
- Reschke M, Ferby I, Stepniak E, Seitzer N, Horst D, Wagner E, et al. Mitogen-inducible gene-6 is a negative regulator of epidermal growth factor receptor signaling in hepatocytes and human hepatocellular carcinoma. Hepatology. 2010;51:1383-90 pubmed publisher..Our data implicate mig-6 as a regulator of EGFR activity in hepatocytes and as a suppressor of EGFR signaling in human liver cancer. ..
- Neumann J, Schaale K, Farhat K, Endermann T, Ulmer A, Ehlers S, et al. Frizzled1 is a marker of inflammatory macrophages, and its ligand Wnt3a is involved in reprogramming Mycobacterium tuberculosis-infected macrophages. FASEB J. 2010;24:4599-612 pubmed publisher..The current data support the notion that evolutionarily conserved Wnt/Fzd signaling is involved in balancing the inflammatory response to microbial stimulation of innate immune cells of vertebrate origin. ..
- Thiele S, de Sanctis L, Werner R, Grötzinger J, Aydin C, Juppner H, et al. Functional characterization of GNAS mutations found in patients with pseudohypoparathyroidism type Ic defines a new subgroup of pseudohypoparathyroidism affecting selectively Gs?-receptor interaction. Hum Mutat. 2011;32:653-60 pubmed publisher..L388P disrupted both receptor-mediated activation and receptor-independent activation. We present a new subgroup of PHP that is caused by Gs? deficiency and selectively affects receptor coupling functions of Gs?. ..
- Kaulfuß S, Seemann H, Kampe R, Meyer J, Dressel R, König B, et al. Blockade of the PDGFR family together with SRC leads to diminished proliferation of colorectal cancer cells. Oncotarget. 2013;4:1037-49 pubmed..g., using Ki11502, represents a promising therapeutic intervention for the treatment of CRC. ..
- Kraus M, Müller Ide H, Rückrich T, Bader J, Overkleeft H, Driessen C. Ritonavir, nelfinavir, saquinavir and lopinavir induce proteotoxic stress in acute myeloid leukemia cells and sensitize them for proteasome inhibitor treatment at low micromolar drug concentrations. Leuk Res. 2014;38:383-92 pubmed publisher
- Kujawski S, Lin W, Kitte F, Börmel M, Fuchs S, Arulmozhivarman G, et al. Calcineurin regulates coordinated outgrowth of zebrafish regenerating fins. Dev Cell. 2014;28:573-87 pubmed publisher..This shift is associated with the promotion of retinoic acid signaling. Thus, we identified a calcineurin-mediated mechanism that operates as a molecular switch between position-associated isometric and allometric growth programs. ..
- Rognoni E, Ruppert R, FÃ¤ssler R. The kindlin family: functions, signaling properties and implications for human disease. J Cell Sci. 2016;129:17-27 pubmed publisher..This Commentary focuses on new and isoform-specific kindlin functions in different tissues and discusses their potential role in disease development and progression. ..
- Fischer J, Bscheider M, Eisenkolb G, Lin C, Wintges A, Otten V, et al. RIG-I/MAVS and STING signaling promote gut integrity during irradiation- and immune-mediated tissue injury. Sci Transl Med. 2017;9: pubmed publisher..Targeting these pathways may help to prevent acute intestinal injury and GVHD during allogeneic transplantation. ..
- Weber M, Beckering C, Marahiel M. Complementation of cold shock proteins by translation initiation factor IF1 in vivo. J Bacteriol. 2001;183:7381-6 pubmed..Two of the possible explanation models are discussed. ..
- Radons J, Gabler S, Wesche H, Korherr C, Hofmeister R, Falk W. Identification of essential regions in the cytoplasmic tail of interleukin-1 receptor accessory protein critical for interleukin-1 signaling. J Biol Chem. 2002;277:16456-63 pubmed..Taken together, our data indicate that box 3 of IL-1RAcP is critical for IL-1-dependent NF-kappaB activation and stabilization of IL-2 mRNA via JNK, whereas aa 527-534 largely contribute to IL-2 promoter activation. ..
- Buchwald G, Friebel A, Gal n J, Hardt W, Wittinghofer A, Scheffzek K. Structural basis for the reversible activation of a Rho protein by the bacterial toxin SopE. EMBO J. 2002;21:3286-95 pubmed publisher..Therefore, SopE represents the first example of a non-Dbl-like protein capable of inducing guanine nucleotide exchange in Rho family proteins...
- Buechler C, Bared S, Aslanidis C, Ritter M, Drobnik W, Schmitz G. Molecular and functional interaction of the ATP-binding cassette transporter A1 with Fas-associated death domain protein. J Biol Chem. 2002;277:41307-10 pubmed..The association of FADD with ABCA1 provides an unexpected link between high density lipoprotein metabolism and an adaptor molecule mainly described in death receptor signal transduction...
- Richter O, Ludwig B. Cytochrome c oxidase--structure, function, and physiology of a redox-driven molecular machine. Rev Physiol Biochem Pharmacol. 2003;147:47-74 pubmed..Moreover, the successful elucidation of 3-D structures for both the mitochondrial and several bacterial oxidases has greatly helped in designing mutagenesis approaches to study functional aspects in these enzymes. ..
- Werner C, Raivich G, Cowen M, Strekalova T, Sillaber I, Buters J, et al. Importance of NO/cGMP signalling via cGMP-dependent protein kinase II for controlling emotionality and neurobehavioural effects of alcohol. Eur J Neurosci. 2004;20:3498-506 pubmed..No taste differences to sweet solutions were observed compared to control animals. In summary, our data show that cGKII activity modulates anxiety-like behaviour and neurobehavioural effects of alcohol. ..
- Kaufmann A, Musset B, Limberg S, Renigunta V, Sus R, Dalpke A, et al. "Host tissue damage" signal ATP promotes non-directional migration and negatively regulates toll-like receptor signaling in human monocytes. J Biol Chem. 2005;280:32459-67 pubmed..Thus, our data suggest that ATP promotes non-directional migration and, importantly, acts as a "host tissue damage" signal via the G(s) protein-coupled P2Y(11) receptor and increased cAMP to negatively regulate TLR signaling. ..
- Kentner D, Thiem S, Hildenbeutel M, Sourjik V. Determinants of chemoreceptor cluster formation in Escherichia coli. Mol Microbiol. 2006;61:407-17 pubmed
- Sheynzon P, Korf H. Targeted deletions of Mel1a and Mel1b melatonin receptors affect pCREB levels in lactotroph and pars intermedia cells of mice. Neurosci Lett. 2006;407:48-52 pubmed..Our results indicate that Mel1a and Mel1b melatonin receptors are involved in the control of the activity state of lactotroph and pars intermedia cells of mice. ..
- Theiner G, Rössner S, Dalpke A, Bode K, Berger T, Gessner A, et al. TLR9 cooperates with TLR4 to increase IL-12 release by murine dendritic cells. Mol Immunol. 2008;45:244-52 pubmed..The stimulatory effect could be further enhanced by addition of IFN-gamma but not anti-CD40 antibodies. These data show, that TLR4 and TLR9 can cooperate to increase selectively IL-12 production by DC. ..
- Kipp A, Banning A, Brigelius Flohe R. Activation of the glutathione peroxidase 2 (GPx2) promoter by beta-catenin. Biol Chem. 2007;388:1027-33 pubmed..Whether up-regulation of GPx2 during carcinogenesis supports tumor growth or can rather be considered as a counteracting effect remains to be investigated. ..
- Richter K, Reinstein J, Buchner J. A Grp on the Hsp90 mechanism. Mol Cell. 2007;28:177-9 pubmed..2007) present the crystal structure of Grp94, which highlights the similarity between Grp94 and Hsp90 and provides insight into the resting state of Grp94 and potentially other Hsp90 family members. ..
- Engels K, Knauer S, Loibl S, Fetz V, Harter P, Schweitzer A, et al. NO signaling confers cytoprotectivity through the survivin network in ovarian carcinomas. Cancer Res. 2008;68:5159-66 pubmed publisher..Pharmacogenetic iNOS/survivin-targeting strategies may hence be pursued to complement current treatment modalities in EOC. ..
- Pupjalis D, Goetsch J, Kottas D, Gerke V, Rescher U. Annexin A1 released from apoptotic cells acts through formyl peptide receptors to dampen inflammatory monocyte activation via JAK/STAT/SOCS signalling. EMBO Mol Med. 2011;3:102-14 pubmed publisher..This identifies annexin A1 as part of the anti-inflammatory pattern of apoptotic cells and links the activation of FPRs to established signalling pathways triggering anti-inflammatory responses. ..
- Rogov V, Rogova N, Bernhard F, Lohr F, Dötsch V. A disulfide bridge network within the soluble periplasmic domain determines structure and function of the outer membrane protein RCSF. J Biol Chem. 2011;286:18775-83 pubmed publisher..Interaction studies showed a weak interaction with an RNA hairpin. However, no interaction could be detected with reagents that are believed to activate the rcs phosphorelay, such as lysozyme, glucose, or Zn(2+) ions. ..
- Kunzmann S, Collins J, Yang Y, Uhlig S, Kallapur S, Speer C, et al. Antenatal inflammation reduces expression of caveolin-1 and influences multiple signaling pathways in preterm fetal lungs. Am J Respir Cell Mol Biol. 2011;45:969-76 pubmed publisher..The decreased concentrations of Cav-1 and changes in other signaling pathways may contribute to BPD...
- Kuzmanov A, Wielockx B, Rezaei M, Kettelhake A, Breier G. Overexpression of factor inhibiting HIF-1 enhances vessel maturation and tumor growth via platelet-derived growth factor-C. Int J Cancer. 2012;131:E603-13 pubmed publisher..Our data suggest that FIH-mediated PDGF-C induction in LM8 osteosarcoma stimulates the recruitment of PDGFR-? positive pericytes to the tumor vasculature, leading to vessel maturation and enhanced tumor growth. ..
- Seiler F, Hellberg J, Lepper P, Kamyschnikow A, Herr C, Bischoff M, et al. FOXO transcription factors regulate innate immune mechanisms in respiratory epithelial cells. J Immunol. 2013;190:1603-13 pubmed publisher..In conclusion, FOXO transcription factors are involved in the cellular responses to bacterial stimuli and act as central regulators of innate immune functions in respiratory epithelial cells. ..
- Bønnelykke K, Matheson M, Pers T, Granell R, Strachan D, Alves A, et al. Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization. Nat Genet. 2013;45:902-906 pubmed publisher..Understanding the molecular mechanisms underlying these associations may provide new insights into the etiology of allergic disease. ..
- Lin Y, Chen L, Herrfurth C, Feussner I, Li H. Reduced Biosynthesis of Digalactosyldiacylglycerol, a Major Chloroplast Membrane Lipid, Leads to Oxylipin Overproduction and Phloem Cap Lignification in Arabidopsis. Plant Cell. 2016;28:219-32 pubmed publisher..Our results demonstrate a link between the biosynthesis of DGDG and JA. ..
- Kreitmeier M, Gerisch G, Heizer C, Müller Taubenberger A. A talin homologue of Dictyostelium rapidly assembles at the leading edge of cells in response to chemoattractant. J Cell Biol. 1995;129:179-88 pubmed..The ordered assembly of the talin homologue together with actin and a series of other proteins is considered to play a key role in chemotactic orientation. ..
- Obukhov A, Harteneck C, Zobel A, Harhammer R, Kalkbrenner F, Leopoldt D, et al. Direct activation of trpl cation channels by G alpha11 subunits. EMBO J. 1996;15:5833-8 pubmed..Thus, G proteins of the Gq subfamily may induce Ca2+ entry not only indirectly via store-operated mechanisms but also by directly stimulating cation channels. ..
- Ciapponi L, Jackson D, Mlodzik M, Bohmann D. Drosophila Fos mediates ERK and JNK signals via distinct phosphorylation sites. Genes Dev. 2001;15:1540-53 pubmed..These results indicate that the distinction between ERK and JNK signals can be made at the level of D-Fos, and that different pathway-specific phosphorylated forms of the protein can elicit different responses. ..
- Forster E, Tielsch A, Saum B, Weiss K, Johanssen C, Graus Porta D, et al. Reelin, Disabled 1, and beta 1 integrins are required for the formation of the radial glial scaffold in the hippocampus. Proc Natl Acad Sci U S A. 2002;99:13178-83 pubmed..Moreover, recombinant Reelin induced branching of glial processes in vitro. Our data suggest that Reelin affects glial differentiation via Disabled 1 and beta(1)-class integrin-dependent signaling pathways. ..
- Zirn B, Samans B, Wittmann S, Pietsch T, Leuschner I, Graf N, et al. Target genes of the WNT/beta-catenin pathway in Wilms tumors. Genes Chromosomes Cancer. 2006;45:565-74 pubmed..This article contains Supplementary Material available at http://www.interscience.wiley.com/jpages/1045-2257/suppmat. ..
- Günther J, Esch K, Poschadel N, Petzl W, Zerbe H, Mitterhuemer S, et al. Comparative kinetics of Escherichia coli- and Staphylococcus aureus-specific activation of key immune pathways in mammary epithelial cells demonstrates that S. aureus elicits a delayed response dominated by interleukin-6 (IL-6) but not by IL-1A or tu. Infect Immun. 2011;79:695-707 pubmed publisher..aureus within the udder. We suggest that S. aureus subverts the MyD88-dependent activation of immune gene expression in MEC. ..
- Geissler A, Haun F, Frank D, Wieland K, Simon M, Idzko M, et al. Apoptosis induced by the fungal pathogen gliotoxin requires a triple phosphorylation of Bim by JNK. Cell Death Differ. 2013;20:1317-29 pubmed publisher..These data indicate that JNK-mediated BimEL phosphorylation at S100, T112 and S114 constitutes a novel regulatory mechanism to activate Bim in response to apoptotic stimuli. ..
- Laugwitz K, Allgeier A, Offermanns S, Spicher K, Van Sande J, Dumont J, et al. The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families. Proc Natl Acad Sci U S A. 1996;93:116-20 pubmed
- Kronenberg S, Esser C, Carlberg C. An aryl hydrocarbon receptor conformation acts as the functional core of nuclear dioxin signaling. Nucleic Acids Res. 2000;28:2286-91 pubmed..In conclusion, the results of this study provide important information on the ligand sensitivity of AhR and AhR-Arnt heterodimer conformations. ..
- Hammer S, Spika I, Sippl W, Jessen G, Kleuser B, Höltje H, et al. Glucocorticoid receptor interactions with glucocorticoids: evaluation by molecular modeling and functional analysis of glucocorticoid receptor mutants. Steroids. 2003;68:329-39 pubmed..Asn-564 is shown to be very important for ligand binding and even more for target gene activation and transcription factor repression. ..
- Scharschmidt E, Wegener E, Heissmeyer V, Rao A, Krappmann D. Degradation of Bcl10 induced by T-cell activation negatively regulates NF-kappa B signaling. Mol Cell Biol. 2004;24:3860-73 pubmed..Together, these results suggest a new mechanism of negative signaling in which TCR/PKC signaling initially activates Bcl10 but later promotes its degradation. ..
- Meissner B, Boll M, Daniel H, Baumeister R. Deletion of the intestinal peptide transporter affects insulin and TOR signaling in Caenorhabditis elegans. J Biol Chem. 2004;279:36739-45 pubmed
- Klein R. Eph/ephrin signaling in morphogenesis, neural development and plasticity. Curr Opin Cell Biol. 2004;16:580-9 pubmed..Mechanistically, Eph-ephrin repulsive behavior appears to require ligand-receptor internalization and signaling to Rho GTPases. ..
- Loers G, Chen S, Grumet M, Schachner M. Signal transduction pathways implicated in neural recognition molecule L1 triggered neuroprotection and neuritogenesis. J Neurochem. 2005;92:1463-76 pubmed..These observations suggest possibilities of differentially targeting signal transduction pathways for L1-dependent neuritogenesis and neuroprotection. ..
- Huwiler A, Pfeilschifter J. Altering the sphingosine-1-phosphate/ceramide balance: a promising approach for tumor therapy. Curr Pharm Des. 2006;12:4625-35 pubmed..This review will summarize novel insights into the regulation of sphingolipid formation and their potential involvement in tumor development. Finally, we will pinpoint potential new targets for tumor therapy. ..
- Finotto S, Eigenbrod T, Karwot R, Boross I, Doganci A, Ito H, et al. Local blockade of IL-6R signaling induces lung CD4+ T cell apoptosis in a murine model of asthma via regulatory T cells. Int Immunol. 2007;19:685-93 pubmed..Local targeting of IL-6R signaling could be a novel approach for inducing Th2 T cell death in allergic airways via regulatory T cells. ..
- Ermolaeva M, Michallet M, Papadopoulou N, Utermöhlen O, Kranidioti K, Kollias G, et al. Function of TRADD in tumor necrosis factor receptor 1 signaling and in TRIF-dependent inflammatory responses. Nat Immunol. 2008;9:1037-46 pubmed publisher..Thus, TRADD is an essential component of TNFR1 signaling and has a critical but apparently cell type-specific function in TRIF-dependent TLR responses. ..
- AbdAlla S, Lother H, el Missiry A, Langer A, Sergeev P, el Faramawy Y, et al. Angiotensin II AT2 receptor oligomers mediate G-protein dysfunction in an animal model of Alzheimer disease. J Biol Chem. 2009;284:6554-65 pubmed publisher..Thus, Abeta induces the formation of cross-linked AT2 oligomers that contribute to the dysfunction of Galphaq/11 in an animal model of Alzheimer disease. ..
- Tritschler I, Gramatzki D, Capper D, Mittelbronn M, Meyermann R, Saharinen J, et al. Modulation of TGF-beta activity by latent TGF-beta-binding protein 1 in human malignant glioma cells. Int J Cancer. 2009;125:530-40 pubmed publisher..Collectively, we identify LTBP-1 as an important modulator of TGF-beta activation in glioma cells, which may contribute to the malignant phenotype of these tumors. ..
- Hartmann W, Küchler J, Koch A, Friedrichs N, Waha A, Endl E, et al. Activation of phosphatidylinositol-3'-kinase/AKT signaling is essential in hepatoblastoma survival. Clin Cancer Res. 2009;15:4538-45 pubmed publisher..The current study was done to analyze the role of PI3K/AKT signaling in hepatoblastoma...
- Fisslthaler B, Fleming I. Activation and signaling by the AMP-activated protein kinase in endothelial cells. Circ Res. 2009;105:114-27 pubmed publisher..Moreover, there is evidence indicating that the activation of the AMPK may help to prevent the vascular complications associated with the metabolic syndrome. ..
- Rodriguez N, Dietrich H, Mossbrugger I, Weintz G, Scheller J, Hammer M, et al. Increased inflammation and impaired resistance to Chlamydophila pneumoniae infection in Dusp1(-/-) mice: critical role of IL-6. J Leukoc Biol. 2010;88:579-87 pubmed publisher..These data show that DUSP1 is required to achieve a balanced response to chlamydial infection and identify IL-6 as critical for amplifying inflammation and benefiting chlamydial growth through direct effects on infected cells. ..
- Fahlenkamp A, Coburn M, Haase H, Kipp M, Ryang Y, Rossaint R, et al. Xenon enhances LPS-induced IL-1? expression in microglia via the extracellular signal-regulated kinase 1/2 pathway. J Mol Neurosci. 2011;45:48-59 pubmed publisher..In conclusion, xenon enhanced LPS-induced IL-1? expression in microglia by activation of ERK 1/2 signalling. Xenon's interference with phosphatases may be a key feature to affect multiple intracellular signalling pathways...
- Meyer F, Gerwig J, Hammer E, Herzberg C, Commichau F, Volker U, et al. Physical interactions between tricarboxylic acid cycle enzymes in Bacillus subtilis: evidence for a metabolon. Metab Eng. 2011;13:18-27 pubmed publisher..subtilis growing on gluconeogenic carbon sources. Only under gluconeogenic growth conditions an interaction of these two proteins is detectable and disappears under glycolytic growth conditions. ..
- Bonaventure G, VanDoorn A, Baldwin I. Herbivore-associated elicitors: FAC signaling and metabolism. Trends Plant Sci. 2011;16:294-9 pubmed publisher..The interaction between Nicotiana attenuata and the specialist lepidopteran Manduca sexta presents a relevant biological system to understand HAE perception and signal transduction systems in plants. ..
- Bala M, Martin J, Kopp A, Hanses F, Buechler C, Schaffler A. In vivo suppression of visfatin by oral glucose uptake: evidence for a novel incretin-like effect by glucagon-like peptide-1 (GLP-1). J Clin Endocrinol Metab. 2011;96:2493-501 pubmed publisher..The inhibitory effect of GLP-1 on adipocytic visfatin release together with the absence of direct glucose effects on visfatin release suggests the existence of a novel incretin-like effect represented by a GLP-1/visfatin/axis. ..
- Hsu H, Hoffmann S, Di Marco G, Endlich N, Peter Katalinic J, Weide T, et al. Downregulation of the antioxidant protein peroxiredoxin 2 contributes to angiotensin II-mediated podocyte apoptosis. Kidney Int. 2011;80:959-969 pubmed publisher..Both treatment with angiotensin II and downregulation of peroxiredoxin 2 expression led to apoptosis of podocytes. Thus, peroxiredoxin 2 is an important modulator of angiotensin II-induced podocyte injury. ..
- Soufi M, Ruppert V, Kurt B, Schaefer J. The impact of severe LDL receptor mutations on SREBP-pathway regulation in homozygous familial hypercholesterolemia (FH). Gene. 2012;499:218-22 pubmed publisher..Gene expression experiments with LDL receptor lacking primary FH fibroblasts, revealed that SR-BI and ABCA1 are important regulators for cholesterol acquisition in FH cells, consistent with findings in cells from NPC and TD patients...
- Goeppert B, Konermann C, Schmidt C, Bogatyrova O, Geiselhart L, Ernst C, et al. Global alterations of DNA methylation in cholangiocarcinoma target the Wnt signaling pathway. Hepatology. 2014;59:544-54 pubmed publisher..Candidate protein SFRP2 was substantially down-regulated in neoplastic tissues of all BTC subtypes as compared to normal tissues. A significant inverse correlation of SFRP2 protein expression and pT status was found in BTC patients...
- Hu J, Popp R, Frömel T, Ehling M, Awwad K, Adams R, et al. Müller glia cells regulate Notch signaling and retinal angiogenesis via the generation of 19,20-dihydroxydocosapentaenoic acid. J Exp Med. 2014;211:281-95 pubmed publisher..These studies demonstrate that retinal angiogenesis is regulated by a novel form of neuroretina-vascular interaction involving the sEH-dependent generation of a diol of DHA in Müller cells. ..
- Chen X, Schreiber K, Appel J, Makowka A, Fähnrich B, Roettger M, et al. The Entner-Doudoroff pathway is an overlooked glycolytic route in cyanobacteria and plants. Proc Natl Acad Sci U S A. 2016;113:5441-6 pubmed publisher..Furthermore, the ED pathway does not generate futile cycles in organisms that fix CO2 via the Calvin-Benson cycle. ..
- Radeke H, von Wenckstern H, Stoidtner K, Sauer B, Hammer S, Kleuser B. Overlapping signaling pathways of sphingosine 1-phosphate and TGF-beta in the murine Langerhans cell line XS52. J Immunol. 2005;174:2778-86 pubmed..Thus, our data indicate a cross-communication between S1P and TGF-beta signaling that might be relevant for more than only migratory activities of immature LC. ..
- Alnajar A, Nordhoff C, Schied T, Chiquet Ehrismann R, Loser K, Vogl T, et al. The LIM-only protein FHL2 attenuates lung inflammation during bleomycin-induced fibrosis. PLoS ONE. 2013;8:e81356 pubmed publisher..Consequently, FHL2 knockout mice developed a severe and long-lasting lung pathology following bleomycin administration due to enhanced expression of tenascin C and impaired activation of inflammation-resolving macrophages. ..
- Langholz O, Röckel D, Mauch C, Kozlowska E, Bank I, Krieg T, et al. Collagen and collagenase gene expression in three-dimensional collagen lattices are differentially regulated by alpha 1 beta 1 and alpha 2 beta 1 integrins. J Cell Biol. 1995;131:1903-15 pubmed..The data presented here indicate that different signaling pathways exist leading to the three events discussed here, and that these pathways do not per se depend upon each other. ..
- Lang F, Cohen P. Regulation and physiological roles of serum- and glucocorticoid-induced protein kinase isoforms. Sci STKE. 2001;2001:re17 pubmed..This raises the possibility that specific inhibitors of SGK1 may have therapeutic potential for the treatment of several diseases. ..
- Cibelli G, Policastro V, Rössler O, Thiel G. Nitric oxide-induced programmed cell death in human neuroblastoma cells is accompanied by the synthesis of Egr-1, a zinc finger transcription factor. J Neurosci Res. 2002;67:450-60 pubmed..The fact that NO-induced neuronal cell death is accompanied by the biosynthesis of Egr-1 suggests that Egr-1 may be an integral part of the NO triggered apoptotic signaling cascade. ..
- Knobbe C, Merlo A, Reifenberger G. Pten signaling in gliomas. Neuro Oncol. 2002;4:196-211 pubmed..Furthermore, the possibility of selective targeting of PTEN mutant tumor cells by specific pharmacologic inhibitors of members of the Pten/PI3K/Akt pathway opens up new perspectives for a targeted molecular therapy of malignant gliomas. ..
- Allmendinger A, Stoeckel E, Saarma M, Unsicker K, Huber K. Development of adrenal chromaffin cells is largely normal in mice lacking the receptor tyrosine kinase c-Ret. Mech Dev. 2003;120:299-304 pubmed..We therefore conclude that sympathetic neurons and neuroendocrine chromaffin cells profoundly differ in their requirement for c-Ret signaling during development. ..
- Barreto G, Borgmeyer U, Dreyer C. The germ cell nuclear factor is required for retinoic acid signaling during Xenopus development. Mech Dev. 2003;120:415-28 pubmed..The effect of xEmGCNF knockdown on hindbrain patterning is similar to conditions of reduced RA signaling, which may be caused by a reduction of RAR gamma expression specifically in the presumptive hindbrain. ..
- Abdelmohsen K, Gerber P, von Montfort C, Sies H, Klotz L. Epidermal growth factor receptor is a common mediator of quinone-induced signaling leading to phosphorylation of connexin-43: role of glutathione and tyrosine phosphatases. J Biol Chem. 2003;278:38360-7 pubmed..In summary, EGFR-dependent signaling was mediated by protein-tyrosine phosphatase inactivation (menadione), GSH depletion (BQ), and redox-cycling (DMNQ), funneling into the same signaling pathway. ..
- Radsak M, Salih H, Rammensee H, Schild H. Triggering receptor expressed on myeloid cells-1 in neutrophil inflammatory responses: differential regulation of activation and survival. J Immunol. 2004;172:4956-63 pubmed..These results give a new perspective for the regulation of neutrophil inflammatory responses emphasizing the importance of TREM-1 in innate immunity. ..
- Li K, Pasternak C, Härtig E, Haberzettl K, Maxwell A, Klug G. Thioredoxin can influence gene expression by affecting gyrase activity. Nucleic Acids Res. 2004;32:4563-75 pubmed..Furthermore, inhibition of gyrase activity strongly reduces puf and puc expression. Our results reveal a new signaling pathway by which oxygen can affect the expression of bacterial genes...
- Geiselhöringer A, Gaisa M, Hofmann F, Schlossmann J. Distribution of IRAG and cGKI-isoforms in murine tissues. FEBS Lett. 2004;575:19-22 pubmed..These results suggest that IRAG may be involved in cGKI-dependent and -independent pathways. ..
- Buschbeck M, Ullrich A. The unique C-terminal tail of the mitogen-activated protein kinase ERK5 regulates its activation and nuclear shuttling. J Biol Chem. 2005;280:2659-67 pubmed..Taken together, these results indicate that ERK5 signaling is directed by the presence of its unique C-terminal tail, which might be the key to understanding the key role of ERK5 in MAPK signaling. ..
- Hemmersbach R, Krause M, Braucker R, Ivanova K. Graviperception in ciliates: steps in the transduction chain. Adv Space Res. 2005;35:296-9 pubmed..The corresponding data confirm the relaxation of the graviresponses in microgravity as well as the existence of thresholds of graviresponses, which are found to be in the range of 0.4xg (gravikinesis) and 0.6xg (gravitaxis). ..
- Wagner H, Bauer S. All is not Toll: new pathways in DNA recognition. J Exp Med. 2006;203:265-8 pubmed..In addition, recent studies have revealed the existence of TLR-independent pathways that are activated in response to microbial and host nucleic acids. ..
- Prothmann C, Armstrong N, Roth S, Rupp R. Vertebrate Rel proteins exhibit Dorsal-like activities in early Drosophila embryogenesis. Dev Dyn. 2006;235:949-57 pubmed..Our results suggest the interaction between Rel proteins and their cytoplasmic inhibitors as an important interface of evolutionary adaptation. ..
- Furstenberger G, Krieg P, Muller Decker K, Habenicht A. What are cyclooxygenases and lipoxygenases doing in the driver's seat of carcinogenesis?. Int J Cancer. 2006;119:2247-54 pubmed..e., the 5- and platelet-type 12-lipoxygenase exhibit procarcinogenic activities, while 15-lipoxygenase-1 and 15-lipoxygenase-2 may suppress carcinogenesis. ..