Genomes and Genes
Experts and Doctors on signal transduction in Germany
Topic: signal transduction
Publications276 found, 100 shown here
- Hess S, Lindquist S, Scheibel T. Alternative assembly pathways of the amyloidogenic yeast prion determinant Sup35-NM. EMBO Rep. 2007;8:1196-201 pubmed..Low numbers of repeats favour the formation of the filamentous structure, whereas high numbers of repeats favour the formation of amyloid-like fibres. ..
- Grzelinski M, Steinberg F, Martens T, Czubayko F, Lamszus K, Aigner A. Enhanced antitumorigenic effects in glioblastoma on double targeting of pleiotrophin and its receptor ALK. Neoplasia. 2009;11:145-56 pubmed..We conclude that double targeting of PTN and ALK leads to enhanced antitumorigenic effects over single knockdown approaches, which offers novel therapeutic options owing to increased efficacy also after prolonged knockdown. ..
- Stockert J, Wolf A, Kaddatz K, Schnitzer E, Finkernagel F, Meissner W, et al. Regulation of TAK1/TAB1-mediated IL-1? signaling by cytoplasmic PPAR?/?. PLoS ONE. 2013;8:e63011 pubmed publisher..These observations suggest that PPAR?/? plays a role in the assembly of a cytoplasmic multi-protein complex containing TAK1, TAB1, HSP27 and PPAR?/?, and thereby participates in the NF?B response to IL-1?. ..
- Klouche M, Bhakdi S, Hemmes M, Rose John S. Novel path to activation of vascular smooth muscle cells: up-regulation of gp130 creates an autocrine activation loop by IL-6 and its soluble receptor. J Immunol. 1999;163:4583-9 pubmed
- Roth J, Vogl T, Sorg C, Sunderkotter C. Phagocyte-specific S100 proteins: a novel group of proinflammatory molecules. Trends Immunol. 2003;24:155-8 pubmed..S100A12 directly activates endothelial cells, mononuclear phagocytes and lymphocytes through interaction with the receptor for advanced glycation end products. Thus, these S100-proteins are attractive targets to modulate inflammation. ..
- Siveke J, Lubeseder Martellato C, Lee M, Mazur P, Nakhai H, Radtke F, et al. Notch signaling is required for exocrine regeneration after acute pancreatitis. Gastroenterology. 2008;134:544-55 pubmed publisher..Our results suggest an interaction of Notch and Wnt signaling in pancreatic acinar cells, providing evidence for a role of these pathways in the regulation of the maturation process of acinar cells. ..
- Hart M, Jacobi B, Schittenhelm J, Henn M, Eltzschig H. Cutting Edge: A2B Adenosine receptor signaling provides potent protection during intestinal ischemia/reperfusion injury. J Immunol. 2009;182:3965-8 pubmed publisher..Taken together, these studies demonstrate the A2BAR as a novel therapeutic target for protection during gastrointestinal IR injury. ..
- Cao Y, Oswald F, Wacker S, Bundschu K, Kn chel W. Reversal of Xenopus Oct25 function by disruption of the POU domain structure. J Biol Chem. 2010;285:8408-21 pubmed publisher..Therefore, our results reveal that the integrity of the POU domain is crucial for the function of POU-V transcription factors in the regulation of genes that promote germ layer formation...
- Keim A, Rössler O, Rothhaar T, Thiel G. Arsenite-induced apoptosis of human neuroblastoma cells requires p53 but occurs independently of c-Jun. Neuroscience. 2012;206:25-38 pubmed publisher..Together, these data show that the upregulation of p53 is causally linked with arsenite-induced cell death in neuroblastoma cells, whereas the upregulation of c-Jun is not part of this apoptotic signaling cascade...
- Leibrock C, Alesutan I, Voelkl J, Michael D, Castor T, Kohlhofer U, et al. Acetazolamide sensitive tissue calcification and aging of klotho-hypomorphic mice. J Mol Med (Berl). 2016;94:95-106 pubmed publisher..In kl/kl mice, ACM reversed tissue calcification despite continued hyperphosphatemia. ACM tripled the life span of kl/kl mice. In human aortic smooth muscle cells, low extracellular pH prevented osteogenic signaling. ..
- Schuster S, Noegel A, Oehme F, Gerisch G, Simon M. The hybrid histidine kinase DokA is part of the osmotic response system of Dictyostelium. EMBO J. 1996;15:3880-9 pubmed..dokA is a member of a family of histidine kinase-like genes that play regulatory roles in eukaryotic cell function. ..
- Haserück N, Erl W, Pandey D, Tigyi G, Ohlmann P, Ravanat C, et al. The plaque lipid lysophosphatidic acid stimulates platelet activation and platelet-monocyte aggregate formation in whole blood: involvement of P2Y1 and P2Y12 receptors. Blood. 2004;103:2585-92 pubmed
- Schulte J, Schramm A, Klein Hitpass L, Klenk M, Wessels H, Hauffa B, et al. Microarray analysis reveals differential gene expression patterns and regulation of single target genes contributing to the opposing phenotype of TrkA- and TrkB-expressing neuroblastomas. Oncogene. 2005;24:165-77 pubmed..Fine-tuning of the malignant phenotype may be achieved by additional ligand stimulation with subsequent activation of a few specific genes. ..
- Wenzel J, Wörenkämper E, Freutel S, Henze S, Haller O, Bieber T, et al. Enhanced type I interferon signalling promotes Th1-biased inflammation in cutaneous lupus erythematosus. J Pathol. 2005;205:435-42 pubmed..It is proposed that type I IFNs induce a Th1-biased inflammatory immune response, with recruitment of CXCR3-expressing T-lymphocytes into the skin. ..
- Kotzsch A, Nickel J, Seher A, Heinecke K, van Geersdaele L, Herrmann T, et al. Structure analysis of bone morphogenetic protein-2 type I receptor complexes reveals a mechanism of receptor inactivation in juvenile polyposis syndrome. J Biol Chem. 2008;283:5876-87 pubmed
- Friauf E, Wenz M, Oberhofer M, Nothwang H, Balakrishnan V, Knipper M, et al. Hypothyroidism impairs chloride homeostasis and onset of inhibitory neurotransmission in developing auditory brainstem and hippocampal neurons. Eur J Neurosci. 2008;28:2371-80 pubmed publisher..Hippocampal neurons of hypothyroid P16-17 rats also demonstrated an impaired Cl(-) homeostasis, indicating that TH may have promoted the D/H shift and maturation of synaptic inhibition throughout the brain. ..
- Aso Y, Herb A, Ogueta M, Siwanowicz I, Templier T, Friedrich A, et al. Three dopamine pathways induce aversive odor memories with different stability. PLoS Genet. 2012;8:e1002768 pubmed publisher..These results cast light on a cellular mechanism by which a noxious event induces different dopamine signals to a single brain structure to synthesize an aversive memory. ..
- Fischer M, Reeh P. Sensitization to heat through G-protein-coupled receptor pathways in the isolated sciatic mouse nerve. Eur J Neurosci. 2007;25:3570-5 pubmed..To a surprising degree, peripheral nerve axons resemble peripheral sensory terminals in their common properties of sensory and signal transduction. ..
- Essig K, Hu D, Guimaraes J, Alterauge D, Edelmann S, Raj T, et al. Roquin Suppresses the PI3K-mTOR Signaling Pathway to Inhibit T Helper Cell Differentiation and Conversion of Treg to Tfr Cells. Immunity. 2017;47:1067-1082.e12 pubmed publisher..Thereby, Roquin-mediated control of PI3K-mTOR signaling prevents autoimmunity by restraining activation and differentiation of conventional TÂ cells and specialization of Treg cells. ..
- Yentrapalli R, Azimzadeh O, Barjaktarovic Z, Sarioglu H, Wojcik A, Harms Ringdahl M, et al. Quantitative proteomic analysis reveals induction of premature senescence in human umbilical vein endothelial cells exposed to chronic low-dose rate gamma radiation. Proteomics. 2013;13:1096-107 pubmed publisher..This study contributes to the understanding of the increased risk of cardiovascular diseases seen in populations exposed to chronic low-dose irradiation. ..
- Ritter M, Kattmann D, Teichler S, Hartmann O, Samuelsson M, Burchert A, et al. Inhibition of retinoic acid receptor signaling by Ski in acute myeloid leukemia. Leukemia. 2006;20:437-43 pubmed..The inhibition by wild-type Ski could partially be reverted by the histone deacetylase blocking agent valproic acid. In conclusion, Ski seems to be involved in the blocking of differentiation in AML via inhibition of RARalpha signaling. ..
- Hoffmann U, Heilmann K, Hayford C, Stallmach A, Wahnschaffe U, Zeitz M, et al. CD44v7 ligation downregulates the inflammatory immune response in Crohn's disease patients by apoptosis induction in mononuclear cells from the lamina propria. Cell Death Differ. 2007;14:1542-51 pubmed..The process is highly specific for macrophage activation via CD40. These findings point to a novel mechanism of apoptosis induction in CD patients mediated by CD44v7 ligation. ..
- Weyand M, Schlichting I, Marabotti A, Mozzarelli A. Crystal structures of a new class of allosteric effectors complexed to tryptophan synthase. J Biol Chem. 2002;277:10647-52 pubmed..In this case, closure of loop alphaL6 is no longer observed, in agreement with its functioning only as an inhibitor of the alpha-subunit reaction. ..
- Eissmann P, Beauchamp L, Wooters J, Tilton J, Long E, Watzl C. Molecular basis for positive and negative signaling by the natural killer cell receptor 2B4 (CD244). Blood. 2005;105:4722-9 pubmed..We now show that Fyn can also associate with phosphorylated 2B4. Finally, we demonstrate that Fyn and Csk can both phosphorylate 2B4, suggesting a possible mechanism of 2B4 phosphorylation. ..
- Oehme I, Bosser S, Zörnig M. Agonists of an ecdysone-inducible mammalian expression system inhibit Fas Ligand- and TRAIL-induced apoptosis in the human colon carcinoma cell line RKO. Cell Death Differ. 2006;13:189-201 pubmed..Therefore, the ecdysone-inducible mammalian expression system may not be suitable for the analysis of apoptosis-related genes. ..
- Thiem S, Sourjik V. Stochastic assembly of chemoreceptor clusters in Escherichia coli. Mol Microbiol. 2008;68:1228-36 pubmed publisher..Upon subsequent anchorage to defined lateral sites, clusters grow with rates that inversely depend on their size, and become polar upon several rounds of cell division. ..
- Belgardt B, Mauer J, Wunderlich F, Ernst M, Pal M, Spohn G, et al. Hypothalamic and pituitary c-Jun N-terminal kinase 1 signaling coordinately regulates glucose metabolism. Proc Natl Acad Sci U S A. 2010;107:6028-33 pubmed publisher..Collectively, these experiments reveal an unexpected, critical role for hypothalamic/pituitary JNK1 signaling in the coordination of metabolic/endocrine homeostasis. ..
- Scheu P, Kim O, Griesinger C, Unden G. Sensing by the membrane-bound sensor kinase DcuS: exogenous versus endogenous sensing of C(4)-dicarboxylates in bacteria. Future Microbiol. 2010;5:1383-402 pubmed publisher..Therefore, DcuS senses C(4)-dicarboxylates in two independent modes, responding to the effector concentration and the metabolic flux of extracellular C(4)-dicarboxylates. ..
- Juillot S, Beyer H, Madl J, Weber W, Zurbriggen M, RÃ¶mer W. Signalling to the nucleus under the control of light and small molecules. Mol Biosyst. 2016;12:345-9 pubmed publisher..We synthetically designed an entire cell signalling pathway, which allows controlling the transport of signalling molecules from the plasma membrane to the nucleus, by using light and small molecules. ..
- Hocke S, Guo Y, Job A, Orth M, Ziesch A, Lauber K, et al. A synthetic lethal screen identifies ATR-inhibition as a novel therapeutic approach for POLD1-deficient cancers. Oncotarget. 2016;7:7080-95 pubmed publisher..POLD1 deficiency might thus represent a predictive marker for treatment response towards ATR- or CHK1-inhibitors that are currently tested in clinical trials. ..
- Weidemann W, Klukas C, Klein A, Simm A, Schreiber F, Horstkorte R. Lessons from GNE-deficient embryonic stem cells: sialic acid biosynthesis is involved in proliferation and gene expression. Glycobiology. 2010;20:107-17 pubmed publisher..Furthermore, we identified growth-related genes that are differentially expressed in GNE-deficient embryonic stem cells compared to wild-type embryonic stem cells. ..
- El Maadidi S, Faletti L, Berg B, Wenzl C, Wieland K, Chen Z, et al. A novel mitochondrial MAVS/Caspase-8 platform links RNA virus-induced innate antiviral signaling to Bax/Bak-independent apoptosis. J Immunol. 2014;192:1171-83 pubmed publisher..Thus, after RNA virus infection MAVS does not only elicit a type I antiviral response but also recruits caspase-8 to mitochondria to mediate caspase-3 activation and apoptosis in a Bax/Bak-independent manner. ..
- Gharib S, Loth D, Soler Artigas M, Birkland T, Wilk J, Wain L, et al. Integrative pathway genomics of lung function and airflow obstruction. Hum Mol Genet. 2015;24:6836-48 pubmed publisher..By integrating pathway analysis with population-based genomics, we unraveled biologic processes underlying pulmonary function traits and identified a candidate gene for obstructive lung disease. ..
- Bruggemann H, Baumer S, Fricke W, Wiezer A, Liesegang H, Decker I, et al. The genome sequence of Clostridium tetani, the causative agent of tetanus disease. Proc Natl Acad Sci U S A. 2003;100:1316-21 pubmed..tetani: The organism can rely on an extensive sodium ion bioenergetics. Additional candidate genes involved in the establishment and maintenance of a pathogenic lifestyle of C. tetani are presented...
- Li G, Tolstonog G, Traub P. Interaction in vitro of type III intermediate filament proteins with Z-DNA and B-Z-DNA junctions. DNA Cell Biol. 2003;22:141-69 pubmed
- Boknik P, Grote Wessels S, Barteska G, Jiang M, Muller F, Schmitz W, et al. Genetic disruption of G proteins, G(i2)alpha or G(o)alpha, does not abolish inotropic and chronotropic effects of stimulating muscarinic cholinoceptors in atrium. Br J Pharmacol. 2009;158:1557-64 pubmed publisher..Moreover, different G proteins mediate the effect of carbachol in ventricle compared with atrium. ..
- Lee S, Stack A, Katzowitsch E, Aizawa S, Suerbaum S, Josenhans C. Helicobacter pylori flagellins have very low intrinsic activity to stimulate human gastric epithelial cells via TLR5. Microbes Infect. 2003;5:1345-56 pubmed..pylori to preserve the essential function of its flagella during chronic colonization of the stomach and to evade the deleterious host immune responses. ..
- Prabhu Y, Eichinger L. The Dictyostelium repertoire of seven transmembrane domain receptors. Eur J Cell Biol. 2006;85:937-46 pubmed..discoideum was surprising because they had not been observed outside the animal kingdom before. Their presence suggests unprecedentedly complex and so far unknown signaling activities in this lower eukaryote. ..
- Sengstake S, Boneberg E, Illges H. CD21 and CD62L shedding are both inducible via P2X7Rs. Int Immunol. 2006;18:1171-8 pubmed..P2X7R-mediated CD62L and CD21 shedding could occur as a result of extracellular accumulated ATP and may have an influence on leukocyte migrational behavior and BCR-mediated signaling. ..
- Wendel C, Hemping Bovenkerk A, Krasnyanska J, Mees S, Kochetkova M, Stoeppeler S, et al. CXCR4/CXCL12 participate in extravasation of metastasizing breast cancer cells within the liver in a rat model. PLoS ONE. 2012;7:e30046 pubmed publisher..Chemokine-induced extravasation of breast cancer cells along specific ECM components appears to be an important regulator but not a rate-limiting factor of their metastatic organ colonization. ..
- Wrenger S, Faust J, Mrestani Klaus C, Fengler A, Stockel Maschek A, Lorey S, et al. Down-regulation of T cell activation following inhibition of dipeptidyl peptidase IV/CD26 by the N-terminal part of the thromboxane A2 receptor. J Biol Chem. 2000;275:22180-6 pubmed..These data suggest that the N-terminal part of TXA2-R is an endogenous inhibitory ligand of DP IV and may modulate T cell activation via DP IV/CD26 inhibition. ..
- Tucker M, Hinze A, Tucker E, Takada S, Jurgens G, Laux T. Vascular signalling mediated by ZWILLE potentiates WUSCHEL function during shoot meristem stem cell development in the Arabidopsis embryo. Development. 2008;135:2839-43 pubmed publisher..Thus, WUS-dependent OC signalling to the stem cells is promoted by AGO1 and subsequently maintained by a provascular ZLL-dependent signalling pathway. ..
- Le Nevé B, Daniel H. Selected tetrapeptides lead to a GLP-1 release from the human enteroendocrine cell line NCI-H716. Regul Pept. 2011;167:14-20 pubmed publisher..This tetrapeptide sensing in NCI-H716 cells may be underlying the effective stimulation of hormone secretion shown for various protein hydrolysates, and could involve a novel G-protein-coupled receptor (GPCR). ..
- Adam M, Berger C, Feldner A, Yang W, Wüstehube Lausch J, Herberich S, et al. Synaptojanin-2 binding protein stabilizes the Notch ligands DLL1 and DLL4 and inhibits sprouting angiogenesis. Circ Res. 2013;113:1206-18 pubmed publisher..These data identify SYNJ2BP as a novel inhibitor of tip cell formation, executing its functions predominately by promoting Delta-Notch signaling. ..
- Muehlich S, Gudermann T. Pro-senescence therapy for hepatocellular carcinoma. Aging (Albany NY). 2013;5:639-40 pubmed
- Herrmann S, Recht S, Boenn M, Feldhahn L, Angay O, Fleischmann F, et al. Endogenous rhythmic growth in oak trees is regulated by internal clocks rather than resource availability. J Exp Bot. 2015;66:7113-27 pubmed publisher..Ectomycorrhizal symbiosis may play a previously unsuspected role in smoothing these oscillations without modifying the rhythmic growth pattern. ..
- Riedel K, Hentzer M, Geisenberger O, Huber B, Steidle A, Wu H, et al. N-acylhomoserine-lactone-mediated communication between Pseudomonas aeruginosa and Burkholderia cepacia in mixed biofilms. Microbiology. 2001;147:3249-62 pubmed
- Avramidou A, Kroczek C, Lang C, Schuh W, Jäck H, Mielenz D. The novel adaptor protein Swiprosin-1 enhances BCR signals and contributes to BCR-induced apoptosis. Cell Death Differ. 2007;14:1936-47 pubmed..Finally, ectopic Swiprosin-1 expression enhanced BCR-induced cell death in primary, LPS-stimulated splenic B cells. Hence, Swiprosin-1 may regulate lifespan and BCR signaling thresholds in immature B cells. ..
- Lischke A, Moriggl R, Brandlein S, Berchtold S, Kammer W, Sebald W, et al. The interleukin-4 receptor activates STAT5 by a mechanism that relies upon common gamma-chain. J Biol Chem. 1998;273:31222-9 pubmed..In Ba/F3 cells, studies on signal transduction evoked by directed specific receptor homo- or heterodimerization revealed that STAT5 activation can be triggered exclusively by IL-4R heterodimers containing gammac. ..
- Brose N, Betz A, Wegmeyer H. Divergent and convergent signaling by the diacylglycerol second messenger pathway in mammals. Curr Opin Neurobiol. 2004;14:328-40 pubmed
- AbdAlla S, Lother H, el Missiry A, Sergeev P, Langer A, el Faramawy Y, et al. Dominant negative AT2 receptor oligomers induce G-protein arrest and symptoms of neurodegeneration. J Biol Chem. 2009;284:6566-74 pubmed publisher..Thus, AT2 oligomers inducing Galphaq/11 arrest are causally involved in inducing symptoms of neurodegeneration. ..
- Lankat Buttgereit B, Göke R. The tumour suppressor Pdcd4: recent advances in the elucidation of function and regulation. Biol Cell. 2009;101:309-17 pubmed publisher..Interestingly, recent data suggest that Pdcd4 function may depend on cell type and/or genetic background. This review summarizes the current knowledge regarding the function and regulation of Pdcd4. ..
- Breitschopf K, Haendeler J, Malchow P, Zeiher A, Dimmeler S. Posttranslational modification of Bcl-2 facilitates its proteasome-dependent degradation: molecular characterization of the involved signaling pathway. Mol Cell Biol. 2000;20:1886-96 pubmed..Taken together, these results demonstrate a direct protective role for Bcl-2 phosphorylation by MAP kinase against apoptotic challenges to endothelial cells and other cells. ..
- Schaefer L, Babelova A, Kiss E, Hausser H, Baliova M, Krzyzankova M, et al. The matrix component biglycan is proinflammatory and signals through Toll-like receptors 4 and 2 in macrophages. J Clin Invest. 2005;115:2223-33 pubmed..These findings are potentially relevant for the development of new strategies in the treatment of sepsis. ..
- Koelzer S, Klein T. Regulation of expression of Vg and establishment of the dorsoventral compartment boundary in the wing imaginal disc by Suppressor of Hairless. Dev Biol. 2006;289:77-90 pubmed..Thus, de-repression of its target genes obscures the involvement of Su(H) in this process. Furthermore, we provide evidence that Dx does not signal in a Su(H)-independent manner as has been suggested previously. ..
- La Camera S, L Haridon F, Astier J, Zander M, Abou Mansour E, Page G, et al. The glutaredoxin ATGRXS13 is required to facilitate Botrytis cinerea infection of Arabidopsis thaliana plants. Plant J. 2011;68:507-19 pubmed publisher..Furthermore, plants impaired in ATGRXS13 exhibited resistance to B. cinerea. Finally, we present a model whereby B. cinerea takes advantage of defence signalling pathways of the plant to help the colonization of its host...
- Vennemann A, Gerstner A, Kern N, Ferreiros Bouzas N, Narumiya S, Maruyama T, et al. PTGS-2-PTGER2/4 signaling pathway partially protects from diabetogenic toxicity of streptozotocin in mice. Diabetes. 2012;61:1879-87 pubmed publisher..These findings offer the possibility to intervene in early progression of type 1 diabetes by using PTGER-selective agonists. ..
- Sakamaki J, Wilkinson S, Hahn M, Tasdemir N, O Prey J, Clark W, et al. Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function. Mol Cell. 2017;66:517-532.e9 pubmed publisher..These findings therefore identify a distinct and selective mechanism of autophagy regulation. ..
- Schrick K, Mayer U, Horrichs A, Kuhnt C, Bellini C, Dangl J, et al. FACKEL is a sterol C-14 reductase required for organized cell division and expansion in Arabidopsis embryogenesis. Genes Dev. 2000;14:1471-84 pubmed..We propose that synthesis of sterol signals in addition to BRs is important in mediating regulated cell growth and organization during embryonic development. Our results indicate a novel role for sterols in the embryogenesis of plants. ..
- Henneberger C, Jüttner R, Rothe T, Grantyn R. Postsynaptic action of BDNF on GABAergic synaptic transmission in the superficial layers of the mouse superior colliculus. J Neurophysiol. 2002;88:595-603 pubmed
- Kuhn M. Molecular physiology of natriuretic peptide signalling. Basic Res Cardiol. 2004;99:76-82 pubmed
- Poser I, Rothhammer T, Dooley S, Weiskirchen R, Bosserhoff A. Characterization of Sno expression in malignant melanoma. Int J Oncol. 2005;26:1411-7 pubmed..In summary, constitutive Sno expression was identified as an important mechanism to shut off antiproliferative TGF-beta signaling in malignant melanoma. ..
- Claus M, Jaeschke H, Kleinau G, Neumann S, Krause G, Paschke R. A hydrophobic cluster in the center of the third extracellular loop is important for thyrotropin receptor signaling. Endocrinology. 2005;146:5197-203 pubmed..Moreover, our findings provide evidence that a hydrophobic cluster, comprising residues 652-656 of ECL3, strongly influences intramolecular signal transduction and G protein activation of the TSHR. ..
- Hannah M, Krämer K, Geffroy V, Kopka J, Blair M, Erban A, et al. Hybrid weakness controlled by the dosage-dependent lethal (DL) gene system in common bean (Phaseolus vulgaris) is caused by a shoot-derived inhibitory signal leading to salicylic acid-associated root death. New Phytol. 2007;176:537-49 pubmed
- Duffy D, Krstic A, Halasz M, Schwarzl T, Fey D, Iljin K, et al. Integrative omics reveals MYCN as a global suppressor of cellular signalling and enables network-based therapeutic target discovery in neuroblastoma. Oncotarget. 2015;6:43182-201 pubmed publisher..Importantly, this work describes a systems-level approach to systematically uncovering network based vulnerabilities and therapeutic targets for multifactorial diseases by integrating disparate omic data types. ..
- Rudolph J, Oesterhelt D. Chemotaxis and phototaxis require a CheA histidine kinase in the archaeon Halobacterium salinarium. EMBO J. 1995;14:667-73 pubmed..This indicates that CheAH.s. plays a crucial role in chemical and light signal integration, presumably interacting with at least two phototransducers and a number of chemoreceptors...
- Von Groll U, Berger D, Altmann T. The subtilisin-like serine protease SDD1 mediates cell-to-cell signaling during Arabidopsis stomatal development. Plant Cell. 2002;14:1527-39 pubmed..Thus, we propose that SDD1 generates an extracellular signal by meristemoids/guard mother cells and demonstrate that the function of SDD1 is dependent on TMM activity. ..
- Todorov V, Völkl S, Muller M, Bohla A, Klar J, Kunz Schughart L, et al. Tumor necrosis factor-alpha activates NFkappaB to inhibit renin transcription by targeting cAMP-responsive element. J Biol Chem. 2004;279:1458-67 pubmed..Our results strongly suggest that NFkappaB mediates the effect of TNFalpha on renin transcription targeting a CRE in the mouse renin promoter. ..
- Kleinau G, Brehm M, Wiedemann U, Labudde D, Leser U, Krause G. Implications for molecular mechanisms of glycoprotein hormone receptors using a new sequence-structure-function analysis resource. Mol Endocrinol. 2007;21:574-80 pubmed..Moreover, new interrelations of determinants important for selective G protein-mediated activation of GPHRs are resumed. ..
- Klumpp S, Krieglstein J. Reversible phosphorylation of histidine residues in proteins from vertebrates. Sci Signal. 2009;2:pe13 pubmed publisher..1, all of which are targeted by nucleoside diphosphate kinase (which phosphorylates histidines) and protein histidine phosphatase (which dephosphorylates phosphorylated histidines). ..
- Volling K, Thywissen A, Brakhage A, Saluz H. Phagocytosis of melanized Aspergillus conidia by macrophages exerts cytoprotective effects by sustained PI3K/Akt signalling. Cell Microbiol. 2011;13:1130-48 pubmed publisher..fumigatus. For the first time, we show that melanin itself is a crucial component to inhibit macrophage apoptosis which may contribute to dissemination of the fungus within the host. ..
- Wu Y, Chen Z, Ullrich A. EGFR and FGFR signaling through FRS2 is subject to negative feedback control by ERK1/2. Biol Chem. 2003;384:1215-26 pubmed..Our findings support a broader role of FRS2 in EGFR-controlled signaling pathways in A-431 cells and provide insight into a molecular mechanism for ligand-stimulated feedback regulation with FRS2 as a central regulatory switch point. ..
- Commichau F, Forchhammer K, Stülke J. Regulatory links between carbon and nitrogen metabolism. Curr Opin Microbiol. 2006;9:167-72 pubmed..The regulatory networks enable the bacteria to make the appropriate metabolic responses to changing nutrient availabilities in the environment. ..
- Pietrek M, Brinkmann M, Glowacka I, Enlund A, Hävemeier A, Dittrich Breiholz O, et al. Role of the Kaposi's sarcoma-associated herpesvirus K15 SH3 binding site in inflammatory signaling and B-cell activation. J Virol. 2010;84:8231-40 pubmed publisher..However, the PPLP motif is essential for the decrease in B-cell receptor-mediated signaling induced by K15, as measured by calcium mobilization assays...
- Könner A, Hess S, Tovar S, Mesaros A, Sánchez Lasheras C, Evers N, et al. Role for insulin signaling in catecholaminergic neurons in control of energy homeostasis. Cell Metab. 2011;13:720-8 pubmed publisher..Taken together, these data provide in vivo evidence for a critical role of insulin signaling in catecholaminergic neurons to control food intake and energy homeostasis. ..
- Hoene M, Runge H, Haring H, Schleicher E, Weigert C. Interleukin-6 promotes myogenic differentiation of mouse skeletal muscle cells: role of the STAT3 pathway. Am J Physiol Cell Physiol. 2013;304:C128-36 pubmed publisher..These data demonstrate that IL-6 depletion during myogenic differentiation does not reduce the activation of the STAT3-Socs3 cascade, while IL-6 and STAT3 are both necessary to promote myotube fusion. ..
- Carnevalli L, Scognamiglio R, Cabezas Wallscheid N, Rahmig S, Laurenti E, Masuda K, et al. Improved HSC reconstitution and protection from inflammatory stress and chemotherapy in mice lacking granzyme B. J Exp Med. 2014;211:769-79 pubmed publisher..Blockade of GzmB production may help to improve hematopoiesis in various situations of BM stress. ..
- Hobmayer B, Rentzsch F, Kuhn K, Happel C, von Laue C, Snyder P, et al. WNT signalling molecules act in axis formation in the diploblastic metazoan Hydra. Nature. 2000;407:186-9 pubmed publisher..Our results indicate that Wnt signalling may be involved in axis formation in Hydra and support the idea that it was central in the evolution of axial differentiation in early multicellular animals...
- Shankaranarayanan P, Nigam S. IL-4 induces apoptosis in A549 lung adenocarcinoma cells: evidence for the pivotal role of 15-hydroxyeicosatetraenoic acid binding to activated peroxisome proliferator-activated receptor gamma transcription factor. J Immunol. 2003;170:887-94 pubmed..In conclusion, IL-4-induced apoptosis may contribute to severe loss of alveolar structures and infiltration of eosinophils, mononuclear phagocytes, etc., into the lung tissue of chronic asthma patients. ..
- Rose John S, Scheller J, Elson G, Jones S. Interleukin-6 biology is coordinated by membrane-bound and soluble receptors: role in inflammation and cancer. J Leukoc Biol. 2006;80:227-36 pubmed..The pathophysiological mechanisms by which the IL-6/sIL-6R complex regulates the inflammatory state are discussed. ..
- Bach A, Wolgast S, Muhlbauer E, Peschke E. Melatonin stimulates inositol-1,4,5-trisphosphate and Ca2+ release from INS1 insulinoma cells. J Pineal Res. 2005;39:316-23 pubmed..The melatonin effect observed mimics carbachol action. It can be abolished by 30 micromol/L luzindole and is sustained in Ca2+-free medium, suggesting a mechanism that includes the depletion of Ca2+ from intracellular stores. ..
- Schreiber T, Mäusbacher N, Breitkopf S, Grundner Culemann K, Daub H. Quantitative phosphoproteomics--an emerging key technology in signal-transduction research. Proteomics. 2008;8:4416-32 pubmed publisher..Here, we provide an overview of these exciting developments and their potential to transform signal-transduction research into a technology-driven, high-throughput science. ..
- Heermann R, Jung K. The complexity of the 'simple' two-component system KdpD/KdpE in Escherichia coli. FEMS Microbiol Lett. 2010;304:97-106 pubmed publisher..Here, we will discuss the complexity of a 'simple' two-component system and its interconnectivity with metabolism and the general stress response. ..
- Stockert J, Adhikary T, Kaddatz K, Finkernagel F, Meissner W, Müller Brüsselbach S, et al. Reverse crosstalk of TGF? and PPAR?/? signaling identified by transcriptional profiling. Nucleic Acids Res. 2011;39:119-31 pubmed publisher..These observations indicate that PPAR?/? is able to influence the expression of distinct sets of both TGF?-repressed and TGF?-activated genes in both directions. ..
- Hasenauer J, Waldherr S, Doszczak M, Radde N, Scheurich P, Allgöwer F. Identification of models of heterogeneous cell populations from population snapshot data. BMC Bioinformatics. 2011;12:125 pubmed publisher..We demonstrate that the methods are computationally efficient and yield good estimation result even for sparse data sets. ..
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