Genomes and Genes
Experts and Doctors on signal transduction in Germany
Topic: signal transduction
Publications616 found, 100 shown here
- Adams V, Nehrhoff B, Späte U, Linke A, Schulze P, Baur A, et al. Induction of iNOS expression in skeletal muscle by IL-1beta and NFkappaB activation: an in vitro and in vivo study. Cardiovasc Res. 2002;54:95-104 pubmed..These data demonstrate that IL-1beta, together with the priming effect of gamma-IFN, induces iNOS expression in skeletal muscle via activation of ERK1/ERK2 and NFkappaB. ..
- Sakinc T, Kulczak P, Henne K, Gatermann S. Cloning of an agr homologue of Staphylococcus saprophyticus. FEMS Microbiol Lett. 2004;237:157-61 pubmed publisher..epidermidis and S. aureus it does not contain an open reading frame that codes for a protein with homologies to the delta-toxin. Using PCR, the agr was found to be present in clinical isolates of S. saprophyticus...
- Wiesner S, Lange A, Fassler R. Local call: from integrins to actin assembly. Trends Cell Biol. 2006;16:327-9 pubmed..In an exciting publication, Butler et al. have demonstrated for the first time that purified adhesion complexes possess the entire machinery necessary to actively assemble F-actin as a function of integrin activity and clustering...
- Husse B, Briest W, Homagk L, Isenberg G, Gekle M. Cyclical mechanical stretch modulates expression of collagen I and collagen III by PKC and tyrosine kinase in cardiac fibroblasts. Am J Physiol Regul Integr Comp Physiol. 2007;293:R1898-907 pubmed..Myocardial fibrosis due to ECM remodeling contributes to the dysfunction of the failing heart, which might be attributed to changes in hemodynamic loading. ..
- Friedel C, Zimmer R. Influence of degree correlations on network structure and stability in protein-protein interaction networks. BMC Bioinformatics. 2007;8:297 pubmed..Thus, although structural properties of networks can be modified considerably by degree correlations, biological PPI networks do not actually seem to make use of this possibility. ..
- Hirsch B, Hummel M, Bentink S, Fouladi F, Spang R, Zollinger R, et al. CD30-induced signaling is absent in Hodgkin's cells but present in anaplastic large cell lymphoma cells. Am J Pathol. 2008;172:510-20 pubmed publisher..These data suggest that CD30-targeted therapy in ALCL should be combined with NF-kappaB inhibitors to induce effective cell killing. ..
- Lauth M, Rohnalter V, Bergström A, Kooshesh M, Svenningsson P, Toftgard R. Antipsychotic drugs regulate hedgehog signaling by modulation of 7-dehydrocholesterol reductase levels. Mol Pharmacol. 2010;78:486-96 pubmed publisher..Modulation of HH signaling may represent a hitherto undiscovered biological (side) effect of therapeutics used to treat schizophrenia and depression. ..
- ElAli A, Hermann D. Apolipoprotein E controls ATP-binding cassette transporters in the ischemic brain. Sci Signal. 2010;3:ra72 pubmed publisher..ApoE regulated the postischemic abundance of ABCB1 and ABCC1, thereby controlling drug accumulation in the ischemic brain. Our data suggest that inhibition of ApoE signaling may enable improved delivery of drugs to the brain...
- Ratzka C, Liang C, Dandekar T, Gross R, Feldhaar H. Immune response of the ant Camponotus floridanus against pathogens and its obligate mutualistic endosymbiont. Insect Biochem Mol Biol. 2011;41:529-36 pubmed publisher..Likewise, B. floridanus injected into the hemocoel elicited a comparable immune response of its host C. floridanus. Thus, the host immune system may contribute to controlling the endosymbiont population. ..
- Zarbock A, Ley K, McEver R, Hidalgo A. Leukocyte ligands for endothelial selectins: specialized glycoconjugates that mediate rolling and signaling under flow. Blood. 2011;118:6743-51 pubmed publisher..Although the physiologic characterization of these ligands has been obtained in mice, we also note reported similarities and differences with human selectin ligands. ..
- Kunzelmann K, Mehta A. CFTR: a hub for kinases and crosstalk of cAMP and Ca2+. FEBS J. 2013;280:4417-29 pubmed publisher..In CF, the CFTR hub fails to form at the plasma membrane, with widespread detrimental consequences for cell signalling. ..
- Rainger J, Pehlivan D, Johansson S, Bengani H, Sanchez Pulido L, Williamson K, et al. Monoallelic and biallelic mutations in MAB21L2 cause a spectrum of major eye malformations. Am J Hum Genet. 2014;94:915-23 pubmed publisher..The phenotype associated with the homozygous mutation might be a consequence of complete loss of MAB21L2 RNA binding, although the cellular function of this interaction remains unknown. ..
- Ernst J, Grabiec U, Greither T, Fischer B, Dehghani F. The endocannabinoid system in the human granulosa cell line KGN. Mol Cell Endocrinol. 2016;423:67-76 pubmed publisher..g. miR-23a, miR-24, miR-181a and miR-320a. Present data indicate a modulating role of the intrinsic ovarian ECS in the regulation of estradiol synthesis. ..
- Turgeon M, Silander T, Doycheva D, Liao X, Rigden M, Ongaro L, et al. TRH Action Is Impaired in Pituitaries of Male IGSF1-Deficient Mice. Endocrinology. 2017;158:815-830 pubmed publisher..Collectively, these results indicate that impairments in pituitary TRH receptor expression and/or downstream signaling underlie central hypothyroidism in IGSF1 deficiency syndrome. ..
- Tawo R, Pokrzywa W, Kevei E, Akyuz M, Balaji V, Adrian S, et al. The Ubiquitin Ligase CHIP Integrates Proteostasis and Aging by Regulation of Insulin Receptor Turnover. Cell. 2017;169:470-482.e13 pubmed publisher..Our study indicates a competitive relationship between proteostasis and longevity regulation through CHIP-assisted proteolysis, providing a mechanistic concept for understanding the impact of proteome imbalance on aging. ..
- Singh Y, Zhou Y, Zhang S, Abdelazeem K, Elvira B, Salker M, et al. Enhanced Reactive Oxygen Species Production, Acidic Cytosolic pH and Upregulated Na+/H+ Exchanger (NHE) in Dicer Deficient CD4+ T Cells. Cell Physiol Biochem. 2017;42:1377-1389 pubmed publisher..Lack of Dicer leads to oxidative stress, cytosolic acidification, upregulated NHE1 expression and activity as well as swelling of CD4+ T cells, functions all reversed by miR-15b or miR-200b. ..
- Klämbt C, Hummel T, Menne T, Sadlowski E, Scholz H, Stollewerk A. Development and function of embryonic central nervous system glial cells in Drosophila. Dev Genet. 1996;18:40-9 pubmed..The longitudinal glia prefigure longitudinal axon paths and appear capable of regulating the expression of neuronal antigens. In the following we summarize the knowledge on the function of these glial cells. ..
- Takke C, Dornseifer P, v Weizsäcker E, Campos Ortega J. her4, a zebrafish homologue of the Drosophila neurogenic gene E(spl), is a target of NOTCH signalling. Development. 1999;126:1811-21 pubmed..These results suggest that her4 acts as a target of notch-mediated signals that regulate primary neurogenesis. ..
- Orth P, Schnappinger D, Hillen W, Saenger W, Hinrichs W. Structural basis of gene regulation by the tetracycline inducible Tet repressor-operator system. Nat Struct Biol. 2000;7:215-9 pubmed publisher..This forces a pendulum-like motion of helix a4, which increases the separation of the attached DNA binding domains by 3 A, abolishing the affinity of TetR for its operator DNA...
- Bock A, Gross R. The BvgAS two-component system of Bordetella spp.: a versatile modulator of virulence gene expression. Int J Med Microbiol. 2001;291:119-30 pubmed..This review discusses the current knowledge about the molecular mechanisms of virulence regulation and their relevance for infection by these respiratory pathogens. ..
- Scaal M, Pr ls F, F chtbauer E, Patel K, Hornik C, K hler T, et al. BMPs induce dermal markers and ectopic feather tracts. Mech Dev. 2002;110:51-60 pubmed..The data implicate that cDermo-1 is located downstream of BMP in a signaling pathway that leads to condensation of dermal cells. The roles of BMP and cDermo-1 during development of dermis and feather primordia are discussed...
- Nofer J, Feuerborn R, Levkau B, Sokoll A, Seedorf U, Assmann G. Involvement of Cdc42 signaling in apoA-I-induced cholesterol efflux. J Biol Chem. 2003;278:53055-62 pubmed..These results for the first time demonstrate activation of Rho family G proteins and stress kinases by apoA-I and implicate the involvement of Cdc42 and JNK in the apoA-I-induced cholesterol efflux...
- Fleming I, Schulz C, Fichtlscherer B, Kemp B, Fisslthaler B, Busse R. AMP-activated protein kinase (AMPK) regulates the insulin-induced activation of the nitric oxide synthase in human platelets. Thromb Haemost. 2003;90:863-71 pubmed
- Goyal P, Weissmann N, Rose F, Grimminger F, Schäfers H, Seeger W, et al. Identification of novel Nox4 splice variants with impact on ROS levels in A549 cells. Biochem Biophys Res Commun. 2005;329:32-9 pubmed..Taken together, we suggest that Nox4 exists as several isoforms that may have different functions in ROS-related cell signaling. ..
- Ouelhadj A, Kaminski M, Mittag M, Humbeck K. Receptor-like protein kinase HvLysMR1 of barley (Hordeum vulgare L.) is induced during leaf senescence and heavy metal stress. J Exp Bot. 2007;58:1381-96 pubmed..The involvement of HvLysMR1 during heavy metal stress and leaf senescence is discussed. ..
- Zauner H, Sommer R. Evolution of robustness in the signaling network of Pristionchus vulva development. Proc Natl Acad Sci U S A. 2007;104:10086-91 pubmed
- Wollmann P, Zeth K. The structure of RseB: a sensor in periplasmic stress response of E. coli. J Mol Biol. 2007;372:927-41 pubmed..On the basis of the structure of RseB, we suggest that it acts as a sensor of periplasmic stress with a dual functionality: it detects mislocalized lipoproteins and propagates the signal to induce the sigma(E)-response. ..
- Ramer R, Hinz B. Inhibition of cancer cell invasion by cannabinoids via increased expression of tissue inhibitor of matrix metalloproteinases-1. J Natl Cancer Inst. 2008;100:59-69 pubmed..Increased expression of TIMP-1 mediates an anti-invasive effect of cannabinoids. Cannabinoids may therefore offer a therapeutic option in the treatment of highly invasive cancers. ..
- Sticht C, Freier K, Knöpfle K, Flechtenmacher C, Pungs S, Hofele C, et al. Activation of MAP kinase signaling through ERK5 but not ERK1 expression is associated with lymph node metastases in oral squamous cell carcinoma (OSCC). Neoplasia. 2008;10:462-70 pubmed..016, respectively). Our analysis demonstrates the reliability of the combined approach of gene expression profiling, signaling pathway analyses, and tissue microarray analysis to detect novel distinct molecular aberrations in OSCC. ..
- Oostendorp R, Gilfillan S, Parmar A, Schiemann M, Marz S, Niemeyer M, et al. Oncostatin M-mediated regulation of KIT-ligand-induced extracellular signal-regulated kinase signaling maintains hematopoietic repopulating activity of Lin-CD34+CD133+ cord blood cells. Stem Cells. 2008;26:2164-72 pubmed publisher..Our results show that the loss of repopulating activity during KL stimulation is counteracted by OSM through the downregulation of ERK pathway signaling. Disclosure of potential conflicts of interest is found at the end of this article. ..
- Krol E, Mentzel T, Chinchilla D, Boller T, Felix G, Kemmerling B, et al. Perception of the Arabidopsis danger signal peptide 1 involves the pattern recognition receptor AtPEPR1 and its close homologue AtPEPR2. J Biol Chem. 2010;285:13471-9 pubmed publisher..Our findings provide a basic framework to study the biological role of AtPep1-related danger signals and their cognate receptors. ..
- Ohrt T, Muetze J, Svoboda P, Schwille P. Intracellular localization and routing of miRNA and RNAi pathway components. Curr Top Med Chem. 2012;12:79-88 pubmed..We also discuss the consequences of nucleotide analogs introduced into siRNAs which can severely interfere with the natural cytoplasmic localization mediated by Exportin-5 which is required for efficient RISC loading in the cytoplasm. ..
- Pfaffle R, Kies W, Klammt J. From GHRH to IGF-1 and downstream: clinical phenotypes and biological mechanisms. Pediatr Endocrinol Rev. 2011;9 Suppl 1:529-34 pubmed
- Kraxenberger T, Fried L, Behr S, Jung K. First insights into the unexplored two-component system YehU/YehT in Escherichia coli. J Bacteriol. 2012;194:4272-84 pubmed publisher..Moreover, expression was found to be dependent on cyclic AMP (cAMP)/cAMP receptor protein (CRP). It is suggested that YehU/YehT participates in the stationary-phase control network. ..
- Baschieri F, Farhan H. Crosstalk of small GTPases at the Golgi apparatus. Small Gtpases. 2012;3:80-90 pubmed publisher..Finally, we will give a brief overview of available methods and tools to investigate spatio-temporal small GTPase crosstalk...
- Hermeking H. MicroRNAs in the p53 network: micromanagement of tumour suppression. Nat Rev Cancer. 2012;12:613-26 pubmed publisher..In the future, knowledge about the p53-miRNA network may be able to be exploited for diagnostic and therapeutic approaches in cancer prevention and treatment. ..
- Gáspár K, Kukova G, Bünemann E, Buhren B, Sonkoly E, Szollosi A, et al. The chemokine receptor CCR3 participates in tissue remodeling during atopic skin inflammation. J Dermatol Sci. 2013;71:12-21 pubmed publisher..Taken together, findings of the present study suggest that chemokine-driven communication pathways from the epidermis to the dermis may modulate tissue remodeling in atopic skin inflammation. ..
- Garbers C, Scheller J. Interleukin-6 and interleukin-11: same same but different. Biol Chem. 2013;394:1145-61 pubmed publisher..Here, we will discuss how the biochemical similarities are translated into unique and non-redundant functions of IL-6 and IL-11 in vivo and illustrate strategies for cytokine-specific therapeutic intervention. ..
- Heidler J, Fysikopoulos A, Wempe F, Seimetz M, Bangsow T, Tomasovic A, et al. Sestrin-2, a repressor of PDGFR? signalling, promotes cigarette-smoke-induced pulmonary emphysema in mice and is upregulated in individuals with COPD. Dis Model Mech. 2013;6:1378-87 pubmed publisher..Taken together, our results imply that SESN2 could serve as both a biomarker and as a drug target in the clinical management of COPD. ..
- Kuhlmann C, Schaefer C, Reinhold L, Tillmanns H, Erdogan A. Signalling mechanisms of SDF-induced endothelial cell proliferation and migration. Biochem Biophys Res Commun. 2005;335:1107-14 pubmed..05). SDF-1-alpha increases endothelial proliferation and migration involving the activation of BK(Ca) and an increased production of NO. ..
- Krzesz R, Wagner A, Cattaruzza M, Hecker M. Cytokine-inducible CD40 gene expression in vascular smooth muscle cells is mediated by nuclear factor kappaB and signal transducer and activation of transcription-1. FEBS Lett. 1999;453:191-6 pubmed
- Perraud A, Rippe K, Bantscheff M, Glocker M, Lucassen M, Jung K, et al. Dimerization of signalling modules of the EvgAS and BvgAS phosphorelay systems. Biochim Biophys Acta. 2000;1478:341-54 pubmed..In agreement with these data, surface plasmon resonance studies revealed a 2:1 stoichiometry in the interaction of EvgA with the immobilized EvgS HPt domain and an affinity constant of 1. 24x10(6) M(-1)...
- Wilson R, Leptin M. Fibroblast growth factor receptor-dependent morphogenesis of the Drosophila mesoderm. Philos Trans R Soc Lond B Biol Sci. 2000;355:891-5 pubmed..Analysis of the function of dof, which encodes a cytoplasmic protein required for FGF signal transduction may provide an insight into these issues. ..
- Langheinrich U, Hennen E, Stott G, Vacun G. Zebrafish as a model organism for the identification and characterization of drugs and genes affecting p53 signaling. Curr Biol. 2002;12:2023-8 pubmed..We conclude that zebrafish represents a promising model organism for future compound-based and genetic screens and believe that it will help to identify and characterize new anticancer drugs and new targets for cancer treatment. ..
- Vier J, Gerhard M, Wagner H, Hacker G. Enhancement of death-receptor induced caspase-8-activation in the death-inducing signalling complex by uncoupling of oxidative phosphorylation. Mol Immunol. 2004;40:661-70 pubmed..Thus, a mechanism exists by which caspase-8-activation can be accelerated at death receptors and this mechanism can be triggered by targeting mitochondrial oxidative phosphorylation. ..
- Groschl M, Topf H, Kratzsch J, Dotsch J, Rascher W, Rauh M. Salivary leptin induces increased expression of growth factors in oral keratinocytes. J Mol Endocrinol. 2005;34:353-66 pubmed..Based on the findings of our study we assume an important role for salivary leptin in wound healing within the vulnerable oral cavity. ..
- Schreiner B, Voss J, Wischhusen J, Dombrowski Y, Steinle A, Lochmuller H, et al. Expression of toll-like receptors by human muscle cells in vitro and in vivo: TLR3 is highly expressed in inflammatory and HIV myopathies, mediates IL-8 release and up-regulation of NKG2D-ligands. FASEB J. 2006;20:118-20 pubmed
- Schoppmeier M, Schröder R. Maternal torso signaling controls body axis elongation in a short germ insect. Curr Biol. 2005;15:2131-6 pubmed
- Dell S, Peters S, Müther P, Kociok N, Joussen A. The role of PDGF receptor inhibitors and PI3-kinase signaling in the pathogenesis of corneal neovascularization. Invest Ophthalmol Vis Sci. 2006;47:1928-37 pubmed
- Siess W. Platelet interaction with bioactive lipids formed by mild oxidation of low-density lipoprotein. Pathophysiol Haemost Thromb. 2006;35:292-304 pubmed..LPA-mediated platelet activation might contribute to arterial thrombus formation after rupture of atherosclerotic plaques and to the increased blood thrombogenicity of patients with cardiovascular diseases. ..
- Schweiger D, Furstenberger G, Krieg P. Inducible expression of 15-lipoxygenase-2 and 8-lipoxygenase inhibits cell growth via common signaling pathways. J Lipid Res. 2007;48:553-64 pubmed..Our data suggest that 15-LOX-2 and 8-LOX, although displaying different positional specificity, may use common signaling pathways to induce growth inhibition in premalignant epithelial cells. ..
- Sargin B, Choudhary C, Crosetto N, Schmidt M, Grundler R, Rensinghoff M, et al. Flt3-dependent transformation by inactivating c-Cbl mutations in AML. Blood. 2007;110:1004-12 pubmed..Our results indicate an important role of Cbl proteins in Flt3 signal modulation. Also, the data suggest a novel mechanism of leukemic transformation in AML by mutational inactivation of negative RTK regulators. ..
- Schweda F, Friis U, Wagner C, Skott O, Kurtz A. Renin release. Physiology (Bethesda). 2007;22:310-9 pubmed..The unravelling of these mysteries has led to new and interesting insights into the process of renin release. ..
- Commichau F, Stülke J. Trigger enzymes: bifunctional proteins active in metabolism and in controlling gene expression. Mol Microbiol. 2008;67:692-702 pubmed..An analysis of the occurrence of trigger enzymes suggests that the duplication and subsequent functional specialization is a major pattern in their evolution. ..
- Herold S, Hock A, Herkert B, Berns K, Mullenders J, Beijersbergen R, et al. Miz1 and HectH9 regulate the stability of the checkpoint protein, TopBP1. EMBO J. 2008;27:2851-61 pubmed publisher..Our data show that Miz1 and Myc affect the activity of the Atr checkpoint through their effect on TopBP1 chromatin association and stability. ..
- Maeurer C, Holland S, Pierre S, Potstada W, Scholich K. Sphingosine-1-phosphate induced mTOR-activation is mediated by the E3-ubiquitin ligase PAM. Cell Signal. 2009;21:293-300 pubmed publisher..In conclusion we show that PAM is a novel regulator of the mTOR pathway and that PAM may directly activate Rheb as a guanosine exchange factor (GEF). ..
- Schermer B, Benzing T. Lipid-protein interactions along the slit diaphragm of podocytes. J Am Soc Nephrol. 2009;20:473-8 pubmed publisher..The finding that cholesterol interaction regulates the activity of ion channels at the glomerular filtration barrier has important implications for renal physiology and pathophysiology. ..
- Schmidt A, Koch P. Desmosomes: just cell adhesion or is there more?. Cell Adh Migr. 2007;1:28-32 pubmed..Furthermore, there is evidence to suggest that abnormal signaling through these junctions contributes to the symptoms of certain skin and heart diseases. ..
- Messlik A, Schmechel S, Kisling S, Bereswill S, Heimesaat M, Fischer A, et al. Loss of Toll-like receptor 2 and 4 leads to differential induction of endoplasmic reticulum stress and proapoptotic responses in the intestinal epithelium under conditions of chronic inflammation. J Proteome Res. 2009;8:4406-17 pubmed publisher..We hypothesize that ER stress-associated processes in the absence of TLR2 and TLR4 differentially affect host responses and epithelial functions under conditions of genetically driven chronic intestinal inflammation. ..
- Hägele H, Allam R, Pawar R, Reichel C, Krombach F, Anders H. Double-stranded DNA activates glomerular endothelial cells and enhances albumin permeability via a toll-like receptor-independent cytosolic DNA recognition pathway. Am J Pathol. 2009;175:1896-904 pubmed publisher..This innate antiviral response program suggests a novel pathomechanism regulating DNA virus-mediated induction or aggravation of glomerulonephritis. ..
- Reschke M, Ferby I, Stepniak E, Seitzer N, Horst D, Wagner E, et al. Mitogen-inducible gene-6 is a negative regulator of epidermal growth factor receptor signaling in hepatocytes and human hepatocellular carcinoma. Hepatology. 2010;51:1383-90 pubmed publisher..Our data implicate mig-6 as a regulator of EGFR activity in hepatocytes and as a suppressor of EGFR signaling in human liver cancer. ..
- Neumann J, Schaale K, Farhat K, Endermann T, Ulmer A, Ehlers S, et al. Frizzled1 is a marker of inflammatory macrophages, and its ligand Wnt3a is involved in reprogramming Mycobacterium tuberculosis-infected macrophages. FASEB J. 2010;24:4599-612 pubmed publisher..The current data support the notion that evolutionarily conserved Wnt/Fzd signaling is involved in balancing the inflammatory response to microbial stimulation of innate immune cells of vertebrate origin. ..
- Thiele S, de Sanctis L, Werner R, Grötzinger J, Aydin C, Juppner H, et al. Functional characterization of GNAS mutations found in patients with pseudohypoparathyroidism type Ic defines a new subgroup of pseudohypoparathyroidism affecting selectively Gs?-receptor interaction. Hum Mutat. 2011;32:653-60 pubmed publisher..L388P disrupted both receptor-mediated activation and receptor-independent activation. We present a new subgroup of PHP that is caused by Gs? deficiency and selectively affects receptor coupling functions of Gs?. ..
- Kaulfuß S, Seemann H, Kampe R, Meyer J, Dressel R, König B, et al. Blockade of the PDGFR family together with SRC leads to diminished proliferation of colorectal cancer cells. Oncotarget. 2013;4:1037-49 pubmed..g., using Ki11502, represents a promising therapeutic intervention for the treatment of CRC. ..
- Kraus M, Müller Ide H, Rückrich T, Bader J, Overkleeft H, Driessen C. Ritonavir, nelfinavir, saquinavir and lopinavir induce proteotoxic stress in acute myeloid leukemia cells and sensitize them for proteasome inhibitor treatment at low micromolar drug concentrations. Leuk Res. 2014;38:383-92 pubmed publisher
- Kujawski S, Lin W, Kitte F, Börmel M, Fuchs S, Arulmozhivarman G, et al. Calcineurin regulates coordinated outgrowth of zebrafish regenerating fins. Dev Cell. 2014;28:573-87 pubmed publisher..This shift is associated with the promotion of retinoic acid signaling. Thus, we identified a calcineurin-mediated mechanism that operates as a molecular switch between position-associated isometric and allometric growth programs. ..
- Rognoni E, Ruppert R, FÃ¤ssler R. The kindlin family: functions, signaling properties and implications for human disease. J Cell Sci. 2016;129:17-27 pubmed publisher..This Commentary focuses on new and isoform-specific kindlin functions in different tissues and discusses their potential role in disease development and progression. ..
- Fischer J, Bscheider M, Eisenkolb G, Lin C, Wintges A, Otten V, et al. RIG-I/MAVS and STING signaling promote gut integrity during irradiation- and immune-mediated tissue injury. Sci Transl Med. 2017;9: pubmed publisher..Targeting these pathways may help to prevent acute intestinal injury and GVHD during allogeneic transplantation. ..
- Weber M, Beckering C, Marahiel M. Complementation of cold shock proteins by translation initiation factor IF1 in vivo. J Bacteriol. 2001;183:7381-6 pubmed..Two of the possible explanation models are discussed. ..
- Radons J, Gabler S, Wesche H, Korherr C, Hofmeister R, Falk W. Identification of essential regions in the cytoplasmic tail of interleukin-1 receptor accessory protein critical for interleukin-1 signaling. J Biol Chem. 2002;277:16456-63 pubmed..Taken together, our data indicate that box 3 of IL-1RAcP is critical for IL-1-dependent NF-kappaB activation and stabilization of IL-2 mRNA via JNK, whereas aa 527-534 largely contribute to IL-2 promoter activation. ..
- Buchwald G, Friebel A, Gal n J, Hardt W, Wittinghofer A, Scheffzek K. Structural basis for the reversible activation of a Rho protein by the bacterial toxin SopE. EMBO J. 2002;21:3286-95 pubmed publisher..Therefore, SopE represents the first example of a non-Dbl-like protein capable of inducing guanine nucleotide exchange in Rho family proteins...
- Buechler C, Bared S, Aslanidis C, Ritter M, Drobnik W, Schmitz G. Molecular and functional interaction of the ATP-binding cassette transporter A1 with Fas-associated death domain protein. J Biol Chem. 2002;277:41307-10 pubmed..The association of FADD with ABCA1 provides an unexpected link between high density lipoprotein metabolism and an adaptor molecule mainly described in death receptor signal transduction...
- Richter O, Ludwig B. Cytochrome c oxidase--structure, function, and physiology of a redox-driven molecular machine. Rev Physiol Biochem Pharmacol. 2003;147:47-74 pubmed..Moreover, the successful elucidation of 3-D structures for both the mitochondrial and several bacterial oxidases has greatly helped in designing mutagenesis approaches to study functional aspects in these enzymes. ..
- Werner C, Raivich G, Cowen M, Strekalova T, Sillaber I, Buters J, et al. Importance of NO/cGMP signalling via cGMP-dependent protein kinase II for controlling emotionality and neurobehavioural effects of alcohol. Eur J Neurosci. 2004;20:3498-506 pubmed..No taste differences to sweet solutions were observed compared to control animals. In summary, our data show that cGKII activity modulates anxiety-like behaviour and neurobehavioural effects of alcohol. ..
- Kaufmann A, Musset B, Limberg S, Renigunta V, Sus R, Dalpke A, et al. "Host tissue damage" signal ATP promotes non-directional migration and negatively regulates toll-like receptor signaling in human monocytes. J Biol Chem. 2005;280:32459-67 pubmed..Thus, our data suggest that ATP promotes non-directional migration and, importantly, acts as a "host tissue damage" signal via the G(s) protein-coupled P2Y(11) receptor and increased cAMP to negatively regulate TLR signaling. ..
- Kentner D, Thiem S, Hildenbeutel M, Sourjik V. Determinants of chemoreceptor cluster formation in Escherichia coli. Mol Microbiol. 2006;61:407-17 pubmed
- Sheynzon P, Korf H. Targeted deletions of Mel1a and Mel1b melatonin receptors affect pCREB levels in lactotroph and pars intermedia cells of mice. Neurosci Lett. 2006;407:48-52 pubmed..Our results indicate that Mel1a and Mel1b melatonin receptors are involved in the control of the activity state of lactotroph and pars intermedia cells of mice. ..
- Theiner G, Rössner S, Dalpke A, Bode K, Berger T, Gessner A, et al. TLR9 cooperates with TLR4 to increase IL-12 release by murine dendritic cells. Mol Immunol. 2008;45:244-52 pubmed..The stimulatory effect could be further enhanced by addition of IFN-gamma but not anti-CD40 antibodies. These data show, that TLR4 and TLR9 can cooperate to increase selectively IL-12 production by DC. ..
- Kipp A, Banning A, Brigelius Flohe R. Activation of the glutathione peroxidase 2 (GPx2) promoter by beta-catenin. Biol Chem. 2007;388:1027-33 pubmed..Whether up-regulation of GPx2 during carcinogenesis supports tumor growth or can rather be considered as a counteracting effect remains to be investigated. ..
- Richter K, Reinstein J, Buchner J. A Grp on the Hsp90 mechanism. Mol Cell. 2007;28:177-9 pubmed..2007) present the crystal structure of Grp94, which highlights the similarity between Grp94 and Hsp90 and provides insight into the resting state of Grp94 and potentially other Hsp90 family members. ..
- Engels K, Knauer S, Loibl S, Fetz V, Harter P, Schweitzer A, et al. NO signaling confers cytoprotectivity through the survivin network in ovarian carcinomas. Cancer Res. 2008;68:5159-66 pubmed publisher..Pharmacogenetic iNOS/survivin-targeting strategies may hence be pursued to complement current treatment modalities in EOC. ..
- Pupjalis D, Goetsch J, Kottas D, Gerke V, Rescher U. Annexin A1 released from apoptotic cells acts through formyl peptide receptors to dampen inflammatory monocyte activation via JAK/STAT/SOCS signalling. EMBO Mol Med. 2011;3:102-14 pubmed publisher..This identifies annexin A1 as part of the anti-inflammatory pattern of apoptotic cells and links the activation of FPRs to established signalling pathways triggering anti-inflammatory responses. ..
- Rogov V, Rogova N, Bernhard F, Lohr F, Dötsch V. A disulfide bridge network within the soluble periplasmic domain determines structure and function of the outer membrane protein RCSF. J Biol Chem. 2011;286:18775-83 pubmed publisher..Interaction studies showed a weak interaction with an RNA hairpin. However, no interaction could be detected with reagents that are believed to activate the rcs phosphorelay, such as lysozyme, glucose, or Zn(2+) ions. ..
- Kunzmann S, Collins J, Yang Y, Uhlig S, Kallapur S, Speer C, et al. Antenatal inflammation reduces expression of caveolin-1 and influences multiple signaling pathways in preterm fetal lungs. Am J Respir Cell Mol Biol. 2011;45:969-76 pubmed publisher..The decreased concentrations of Cav-1 and changes in other signaling pathways may contribute to BPD...
- Kuzmanov A, Wielockx B, Rezaei M, Kettelhake A, Breier G. Overexpression of factor inhibiting HIF-1 enhances vessel maturation and tumor growth via platelet-derived growth factor-C. Int J Cancer. 2012;131:E603-13 pubmed publisher..Our data suggest that FIH-mediated PDGF-C induction in LM8 osteosarcoma stimulates the recruitment of PDGFR-? positive pericytes to the tumor vasculature, leading to vessel maturation and enhanced tumor growth. ..
- Seiler F, Hellberg J, Lepper P, Kamyschnikow A, Herr C, Bischoff M, et al. FOXO transcription factors regulate innate immune mechanisms in respiratory epithelial cells. J Immunol. 2013;190:1603-13 pubmed publisher..In conclusion, FOXO transcription factors are involved in the cellular responses to bacterial stimuli and act as central regulators of innate immune functions in respiratory epithelial cells. ..
- Bønnelykke K, Matheson M, Pers T, Granell R, Strachan D, Alves A, et al. Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization. Nat Genet. 2013;45:902-906 pubmed publisher..Understanding the molecular mechanisms underlying these associations may provide new insights into the etiology of allergic disease. ..