Genomes and Genes
Experts and Doctors on signal transduction in Canada
Topic: signal transduction
Publications266 found, 100 shown here
- Chen C, Lohnes D. Dominant-negative retinoic acid receptors elicit epidermal defects through a non-canonical pathway. J Biol Chem. 2005;280:3012-21 pubmed..These findings suggest that dnRARs may impact on epidermal development through one or more non-canonical pathways, which are independent of receptor-DNA interaction. ..
- Parreno J, Hart D. Molecular and mechano-biology of collagen gel contraction mediated by human MG-63 cells: involvement of specific intracellular signaling pathways and the cytoskeleton. Biochem Cell Biol. 2009;87:895-904 pubmed publisher..The p38MAPK inhibitor SB203580 modestly affected contraction, but did not affect mRNA levels. These results suggest the potential role of cytoskeletal integrity and multiple kinase signaling pathways in specific bone-remodeling events. ..
- Polosina Y, Cupples C. MutL: conducting the cell's response to mismatched and misaligned DNA. Bioessays. 2010;32:51-9 pubmed publisher..We suggest that the process is regulated by conformational changes in MutL caused by cycles of ATP binding and hydrolysis, and by physiologic changes which influence effector availability. ..
- Scarpella E, Barkoulas M, Tsiantis M. Control of leaf and vein development by auxin. Cold Spring Harb Perspect Biol. 2010;2:a001511 pubmed publisher..These feedbacks may facilitate the iterative generation of basic modules that underlies morphogenesis of both leaves and vasculature. ..
- Las Heras F, Pritzker K, SO A, Tsui H, Chiu B, Inman R, et al. Aberrant chondrocyte hypertrophy and activation of ?-catenin signaling precede joint ankylosis in ank/ank mice. J Rheumatol. 2012;39:583-93 pubmed publisher..We assessed the role of Ank in the maintenance of postnatal articular cartilage using the ank/ank mouse (mice homozygous for progressive ankylosis)...
- Mann K, Davison K, Colombo M, Colosimo A, Diaz Z, Padovani A, et al. Antimony trioxide-induced apoptosis is dependent on SEK1/JNK signaling. Toxicol Lett. 2006;160:158-70 pubmed..These data suggest roles for ROS and the SEK1/JNK pathway in the cytotoxicity associated with Sb(2)O(3) exposure. ..
- Shao W, Yu Z, Fantus I, Jin T. Cyclic AMP signaling stimulates proteasome degradation of thioredoxin interacting protein (TxNIP) in pancreatic beta-cells. Cell Signal. 2010;22:1240-6 pubmed publisher..We suggest that proteasome-dependent TxNIP degradation is a novel mechanism by which Ex-4-cAMP signaling protects pancreatic beta cells. ..
- Campbell Valois F, Pontier S. Implications of Spatiotemporal Regulation of Shigella flexneri Type Three Secretion Activity on Effector Functions: Think Globally, Act Locally. Front Cell Infect Microbiol. 2016;6:28 pubmed publisher..The conservation of a similar regulation of T3SA activity in other pathogens such as Salmonella or Enteropathogenic Escherichia coli will also be briefly discussed. ..
- Botelho R, Teruel M, Dierckman R, Anderson R, Wells A, York J, et al. Localized biphasic changes in phosphatidylinositol-4,5-bisphosphate at sites of phagocytosis. J Cell Biol. 2000;151:1353-68 pubmed
- Okkenhaug K, Wu L, Garza K, La Rose J, Khoo W, Odermatt B, et al. A point mutation in CD28 distinguishes proliferative signals from survival signals. Nat Immunol. 2001;2:325-32 pubmed..Thus, we describe a single point mutation within the CD28 cytoplasmic domain that uncouples signals required for proliferation and survival. ..
- Robert A, Miron M, Champagne C, Gingras M, Branton P, Lavoie J. Distinct cell death pathways triggered by the adenovirus early region 4 ORF 4 protein. J Cell Biol. 2002;158:519-28 pubmed..We conclude that Ad2 E4orf4 induces two distinct cell death responses, whose relative contributions to cell killing may be determined by the genetic background. ..
- Li Y, Hansotia T, Yusta B, Ris F, Halban P, Drucker D. Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis. J Biol Chem. 2003;278:471-8 pubmed
- Gros R, You X, Baggio L, Kabir M, Sadi A, Mungrue I, et al. Cardiac function in mice lacking the glucagon-like peptide-1 receptor. Endocrinology. 2003;144:2242-52 pubmed..These findings provide new evidence implicating an essential role for GLP-1R in the control of murine cardiac structure and function in vivo. ..
- Kramer J, Davidge J, Lockyer J, Staveley B. Expression of Drosophila FOXO regulates growth and can phenocopy starvation. BMC Dev Biol. 2003;3:5 pubmed..This work has implications in the understanding of cancer and insulin related disorders, such as diabetes and obesity. ..
- Leung W, Lawrie A, Demaries S, Massaeli H, Burry A, Yablonsky S, et al. Apolipoprotein D and platelet-derived growth factor-BB synergism mediates vascular smooth muscle cell migration. Circ Res. 2004;95:179-86 pubmed publisher..This study shows that apoD can be expressed or taken up by SMCs and can regulate their motility in response to growth factors...
- Oikonomopoulou K, Hansen K, Saifeddine M, Vergnolle N, Tea I, Blaber M, et al. Kallikrein-mediated cell signalling: targeting proteinase-activated receptors (PARs). Biol Chem. 2006;387:817-24 pubmed..We propose that, like thrombin and trypsin, the kallikreins must now be considered as important 'hormonal' regulators of tissue function, very likely acting in part via PARs. ..
- Fortin C, Lesur O, Fulop T. Effects of TREM-1 activation in human neutrophils: activation of signaling pathways, recruitment into lipid rafts and association with TLR4. Int Immunol. 2007;19:41-50 pubmed..These data shed a new light on how various receptors implicated in the innate immune response could interact to insure an efficient inflammatory response upon pathogens-associated aggression. ..
- Skwarek L, Boulianne G. Great expectations for PIP: phosphoinositides as regulators of signaling during development and disease. Dev Cell. 2009;16:12-20 pubmed publisher..This review summarizes recent work on the role of phosphoinositides in developmental signaling and in a number of diseases and developmental disorders. ..
- Geetha Loganathan P, Nimmagadda S, Antoni L, Fu K, Whiting C, Francis West P, et al. Expression of WNT signalling pathway genes during chicken craniofacial development. Dev Dyn. 2009;238:1150-65 pubmed publisher..These data show that activation of the canonical WNT pathway is feasible in all regions of the face; however, the localization of ligands and antagonists confers specificity. ..
- Fausther M, Pelletier J, Ribeiro C, Sevigny J, Picher M. Cystic fibrosis remodels the regulation of purinergic signaling by NTPDase1 (CD39) and NTPDase3. Am J Physiol Lung Cell Mol Physiol. 2010;298:L804-18 pubmed publisher..This study provides evidence that an extensive remodeling of the enzymatic network regulating clearance occurs in the airways of CF patients. ..
- Bitew T, Sveen C, Heyne B, Zaremberg V. Vitamin E prevents lipid raft modifications induced by an anti-cancer lysophospholipid and abolishes a Yap1-mediated stress response in yeast. J Biol Chem. 2010;285:25731-42 pubmed publisher..Interestingly, the pathway differed from the one triggered by hydrogen peroxide and its activation (measured as Yap1 translocation to the nucleus) was abolished by co-treatment of the cells with alpha-tocopherol. ..
- Kamath B, Bauer R, Loomes K, Chao G, Gerfen J, Hutchinson A, et al. NOTCH2 mutations in Alagille syndrome. J Med Genet. 2012;49:138-44 pubmed publisher..There are only two NOTCH2 families reported to date. This study hypothesised that additional NOTCH2 mutations would be present in patients with clinical features of ALGS without a JAG1 mutation...
- Yougbare I, Boire G, Roy M, Lugnier C, Rouseau E. NCS 613 exhibits anti-inflammatory effects on PBMCs from lupus patients by inhibiting p38 MAPK and NF-?B signalling pathways while reducing proinflammatory cytokine production. Can J Physiol Pharmacol. 2013;91:353-61 pubmed publisher..NCS 613 is a small molecule displaying anti-inflammatory properties that may provide an alternative or complementary strategy for SLE management. ..
- Moorehead R, Sanchez O, Baldwin R, Khokha R. Transgenic overexpression of IGF-II induces spontaneous lung tumors: a model for human lung adenocarcinoma. Oncogene. 2003;22:853-7 pubmed..The MMTV-IGF-II transgenic mice provide a critical model for elucidating the role of IGF-II in this fatal human disease. ..
- Gosselin D, Rivest S. MyD88 signaling in brain endothelial cells is essential for the neuronal activity and glucocorticoid release during systemic inflammation. Mol Psychiatry. 2008;13:480-97 pubmed publisher..Therefore, BBB endothelial cells and not perivascular microglia are the main target of circulating inflammatory mediators to activate the brain circuits and key autonomic functions during systemic immune challenges. ..
- Huh M, Todd M, Picketts D. SCO-ping out the mechanisms underlying the etiology of hydrocephalus. Physiology (Bethesda). 2009;24:117-26 pubmed publisher..Here, we review how altered development and function of the SCO and vel cells contributes to hydrocephalus. ..
- Scrocchi L, Brown T, Drucker D. Leptin sensitivity in nonobese glucagon-like peptide I receptor -/- mice. Diabetes. 1997;46:2029-34 pubmed..Furthermore, the greater effects of leptin on glucose and insulin in leptin-treated versus pair-fed GLP-IR -/- mice raises the possibility that disruption of GLP-I signaling modifies the sensitivity to leptin in vivo. ..
- Eng F, Barsalou A, Akutsu N, Mercier I, Zechel C, Mader S, et al. Different classes of coactivators recognize distinct but overlapping binding sites on the estrogen receptor ligand binding domain. J Biol Chem. 1998;273:28371-7 pubmed
- Lovshin J, Huang Q, Seaberg R, Brubaker P, Drucker D. Extrahypothalamic expression of the glucagon-like peptide-2 receptor is coupled to reduction of glutamate-induced cell death in cultured hippocampal cells. Endocrinology. 2004;145:3495-506 pubmed..These findings establish the presence of a functional GLP-2-GLP-2R axis in the developing rodent brain and demonstrate that GLP-2 exerts cytoprotective actions in cells derived from the central nervous system. ..
- Gauthier C, Li H, Morosoli R. Increase in xylanase production by Streptomyces lividans through simultaneous use of the Sec- and Tat-dependent protein export systems. Appl Environ Microbiol. 2005;71:3085-92 pubmed
- Zhang Y, Bhavnani B. Glutamate-induced apoptosis in neuronal cells is mediated via caspase-dependent and independent mechanisms involving calpain and caspase-3 proteases as well as apoptosis inducing factor (AIF) and this process is inhibited by equine estrogens. BMC Neurosci. 2006;7:49 pubmed..Whether these observations can help in the development of novel therapeutic approaches for the prevention of neurodegenerative diseases with estrogens and calpain inhibitors remains to be investigated. ..
- Zhu T, Gobeil F, Vazquez Tello A, Leduc M, Rihakova L, Bossolasco M, et al. Intracrine signaling through lipid mediators and their cognate nuclear G-protein-coupled receptors: a paradigm based on PGE2, PAF, and LPA1 receptors. Can J Physiol Pharmacol. 2006;84:377-91 pubmed..Intracrine signaling for lipid mediators uncover novel pathways to elicit their effects; accordingly, intracellular GPCRs constitute a distinctive mode of action for gene regulation. ..
- Dang L, Tropepe V. Neural induction and neural stem cell development. Regen Med. 2006;1:635-52 pubmed..A clearer understanding of the molecular and cellular mechanisms that govern mammalian neural cell fate determination will lead to improved ES technology applications in neural regeneration. ..
- Higashihori N, Song Y, Richman J. Expression and regulation of the decoy bone morphogenetic protein receptor BAMBI in the developing avian face. Dev Dyn. 2008;237:1500-8 pubmed publisher..The data suggested that BAMBI could be used to regulate Bmp signaling during tissue interactions that are an integral part of facial morphogenesis. ..
- Köbel M, Huntsman D, Gilks C. Critical molecular abnormalities in high-grade serous carcinoma of the ovary. Expert Rev Mol Med. 2008;10:e22 pubmed publisher..These highly aggressive but chemosensitive tumours are associated with perturbation of molecular pathways leading to genomic instability and extreme mutability and present unique challenges in oncological research and practice...
- McDonald B, Pittman K, Menezes G, Hirota S, Slaba I, Waterhouse C, et al. Intravascular danger signals guide neutrophils to sites of sterile inflammation. Science. 2010;330:362-6 pubmed publisher..Thus, dynamic in vivo imaging revealed a multistep hierarchy of directional cues that guide neutrophil localization to sites of sterile inflammation. ..
- Patel M, Chiang T, Tran V, Lee F, Cote J. The Arf family GTPase Arl4A complexes with ELMO proteins to promote actin cytoskeleton remodeling and reveals a versatile Ras-binding domain in the ELMO proteins family. J Biol Chem. 2011;286:38969-79 pubmed publisher..Furthermore, via binding of an Arf family GTPase, the ELMO-DOCK180 is uniquely positioned at the membrane to activate Rac signaling and remodel the actin cytoskeleton. ..
- Vucic E, Thu K, Robison K, Rybaczyk L, Chari R, Alvarez C, et al. Translating cancer 'omics' to improved outcomes. Genome Res. 2012;22:188-95 pubmed publisher..We focus on the unique advantages of a multidimensional approach to genomic analysis in this new high-throughput omics age and discuss the implications of the changing cancer demographic to translational omics research. ..
- Rangachari M, Kuchroo V. Using EAE to better understand principles of immune function and autoimmune pathology. J Autoimmun. 2013;45:31-9 pubmed publisher..We focus on the step-by-step elucidation of the network of signals required for T helper 17 (Th17) cell differentiation, as well as the molecular dissection of the Tim-3 negative regulatory signaling pathway in Th1 cells. ..
- Boilard E, Pare G, Rousseau M, Cloutier N, Dubuc I, Lévesque T, et al. Influenza virus H1N1 activates platelets through Fc?RIIA signaling and thrombin generation. Blood. 2014;123:2854-63 pubmed publisher..These observations identify both the adaptive immune response and the innate response against pathogens as 2 intertwined processes that activate platelets during influenza infections. ..
- Shum M, Bellmann K, St Pierre P, Marette A. Pharmacological inhibition of S6K1 increases glucose metabolism and Akt signalling in vitro and in diet-induced obese mice. Diabetologia. 2016;59:592-603 pubmed publisher..Our results suggest that specific S6K1 blockade is a valid pharmacological approach to improve glucose disposal in obese diabetic individuals. ..
- Boyce A, Swayne L. P2X7 receptor cross-talk regulates ATP-induced pannexin 1 internalization. Biochem J. 2017;474:2133-2144 pubmed publisher..These findings have important implications for understanding the role of Panx1 in the nervous system and provide important new insights into Panx1-P2X7R cross-talk. ..
- Rouleau J, Kapuku G, Pelletier S, Gosselin H, Adam A, Gagnon C, et al. Cardioprotective effects of ramipril and losartan in right ventricular pressure overload in the rabbit: importance of kinins and influence on angiotensin II type 1 receptor signaling pathway. Circulation. 2001;104:939-44 pubmed..Ramipril attenuates these effects via kinins. Interventions that prevent local increases in Ang II or block AT(1) receptors also prevent decreased responsiveness of the AT(1) receptor in this model. ..
- Zhang Z. Serotonin induces tonic firing in layer V pyramidal neurons of rat prefrontal cortex during postnatal development. J Neurosci. 2003;23:3373-84 pubmed..These results suggest that 5-HT is an important regulator of neuronal activity in the neonatal PFC and may play a role in activity-dependent developmental processes. ..
- Zhu Y, Benn S, Li Z, Wei E, Masih Khan E, Trieu Y, et al. The SH3-SAM adaptor HACS1 is up-regulated in B cell activation signaling cascades. J Exp Med. 2004;200:737-47 pubmed..Our study demonstrates that HACS1 is up-regulated by B cell activation signals and is a participant in B cell activation and differentiation. ..
- Lickert H, Cox B, Wehrle C, Taketo M, Kemler R, Rossant J. Dissecting Wnt/beta-catenin signaling during gastrulation using RNA interference in mouse embryos. Development. 2005;132:2599-609 pubmed..This functional genomic approach allows the rapid identification of functionally important components of embryonic development from large datasets of putative targets. ..
- Boivin B, Lavoie C, Vaniotis G, Baragli A, Villeneuve L, Ethier N, et al. Functional beta-adrenergic receptor signalling on nuclear membranes in adult rat and mouse ventricular cardiomyocytes. Cardiovasc Res. 2006;71:69-78 pubmed..These results highlight differential subcellular localization for betaAR subtypes and indicate that betaAR may have specific roles in regulating nuclear function in cardiomyocytes. ..
- Breit A, Gagnidze K, Devi L, Lagacé M, Bouvier M. Simultaneous activation of the delta opioid receptor (deltaOR)/sensory neuron-specific receptor-4 (SNSR-4) hetero-oligomer by the mixed bivalent agonist bovine adrenal medulla peptide 22 activates SNSR-4 but inhibits deltaOR signaling. Mol Pharmacol. 2006;70:686-96 pubmed..The observation that BAM22 inhibited the Leu-enkephalin-promoted cAMP inhibition in rat dorsal root ganglia neurons supports the potential physiological implication of such regulatory mechanism. ..
- Kang J, Rivest S. MyD88-deficient bone marrow cells accelerate onset and reduce survival in a mouse model of amyotrophic lateral sclerosis. J Cell Biol. 2007;179:1219-30 pubmed..This compelling beneficial effect of MyD88-competent BMDM is a previously unrecognized natural innate immune mechanism of neuroprotection in a mouse model of late-onset motor neuron disease. ..
- Lamy S, Beaulieu E, Labbe D, Bédard V, Moghrabi A, Barrette S, et al. Delphinidin, a dietary anthocyanidin, inhibits platelet-derived growth factor ligand/receptor (PDGF/PDGFR) signaling. Carcinogenesis. 2008;29:1033-41 pubmed publisher..Taken together, these results provide new insight into the molecular mechanisms underlying the antiangiogenic activity of delphinidin that will be helpful for the development of dietary-based chemopreventive strategies. ..
- Girard S, Sebire G, Kadhim H. Proinflammatory orientation of the interleukin 1 system and downstream induction of matrix metalloproteinase 9 in the pathophysiology of human perinatal white matter damage. J Neuropathol Exp Neurol. 2010;69:1116-29 pubmed publisher..Because both of these mediators are known to be involved in neural cell injury, we infer that IL-1 pathway activation has a deleterious role in the pathophysiology of WMD in human neonates. ..
- Dumas A, Lagarde S, Laflamme C, Pouliot M. Oncostatin M decreases interleukin-1 ? secretion by human synovial fibroblasts and attenuates an acute inflammatory reaction in vivo. J Cell Mol Med. 2012;16:1274-85 pubmed publisher..These results as a whole suggest an anti-inflammatory role for OSM, guiding inflammatory processes towards resolution. ..
- Chang H, Balenci L, Okolowsky N, Muller W, Hamel P. Mammary epithelial-restricted expression of activated c-src rescues the block to mammary gland morphogenesis due to the deletion of the C-terminus of Patched-1. Dev Biol. 2012;370:187-97 pubmed publisher..These data reveal the cooperative interactions between signalling cascades involving c-src and Ptch1 and suggest that Hh-signalling may be permissive for c-src/Esr1-dependent mammary gland morphogenesis. ..
- Turcotte M, Allard D, Mittal D, Bareche Y, Buisseret L, JosÃ© V, et al. CD73 Promotes Resistance to HER2/ErbB2 Antibody Therapy. Cancer Res. 2017;77:5652-5663 pubmed publisher..In conclusion, our findings establish CD73 in mediating resistance to trastuzumab and provide new insights into how CD73 is regulated in breast cancer. Cancer Res; 77(20); 5652-63. Â©2017 AACR. ..
- Yeung R, Penninger J, Mak T. T-cell development and function in gene-knockout mice. Curr Opin Immunol. 1994;6:298-307 pubmed..The complex molecular interactions involved in T-cell development and antigen recognition have been especially targeted for detailed analysis via knockout technology. ..
- Damaj B, McColl S, Mahana W, Crouch M, Naccache P. Physical association of Gi2alpha with interleukin-8 receptors. J Biol Chem. 1996;271:12783-9 pubmed..Finally, the results of this study also validate the use of the transfected 293 cell line as a model for the study of the signal transduction pathway(s) initiated by IL-8. ..
- Wang B, Kondo S, Shivji G, Fujisawa H, Mak T, Sauder D. Tumour necrosis factor receptor II (p75) signalling is required for the migration of Langerhans' cells. Immunology. 1996;88:284-8 pubmed
- Chabowski A, Coort S, Calles Escandon J, Tandon N, Glatz J, Luiken J, et al. Insulin stimulates fatty acid transport by regulating expression of FAT/CD36 but not FABPpm. Am J Physiol Endocrinol Metab. 2004;287:E781-9 pubmed..The present studies have shown that insulin regulates protein expression of FAT/CD36, but not FABPpm, via the PI 3-kinase/Akt insulin-signaling pathway. ..
- Bassil M, Anand Srivastava M. Cyclic GMP modulates the expression of Gi protein and adenylyl cyclase signaling in vascular smooth muscle cells. Cell Biochem Biophys. 2007;47:99-108 pubmed..From these studies, it can be suggested that 8Br-cGMP-induced decreased levels of Gi proteins and resultant increased levels of cAMP may be an additional mechanism through which cGMP regulates vascular tone and thereby blood pressure. ..
- Yeung T, Gilbert G, Shi J, Silvius J, Kapus A, Grinstein S. Membrane phosphatidylserine regulates surface charge and protein localization. Science. 2008;319:210-3 pubmed publisher..More strongly cationic proteins, normally associated with the plasma membrane, relocalized to endocytic compartments when the plasma membrane surface charge decreased on calcium influx. ..
- Hui K, Liadis N, Robertson J, Kanungo A, Henderson J. Calcineurin inhibition enhances motor neuron survival following injury. J Cell Mol Med. 2010;14:671-86 pubmed publisher..These data support a model in which calcineurin inhibition promotes neuronal survival, distinct from effects upon neurite outgrowth. ..
- Svendsen P, Formaz Preston A, Leal S, Brook W. The Tbx20 homologs midline and H15 specify ventral fate in the Drosophila melanogaster leg. Development. 2009;136:2689-93 pubmed publisher..Based on these results, we propose that midline and H15 may be considered as the selector genes for ventral leg fate. ..
- Jørgensen C, Sherman A, Chen G, Pasculescu A, Poliakov A, Hsiung M, et al. Cell-specific information processing in segregating populations of Eph receptor ephrin-expressing cells. Science. 2009;326:1502-9 pubmed publisher..We provide systems- and cell-specific network models of contact-initiated signaling between two distinct cell types. ..
- Yogi A, Callera G, O CONNOR S, Antunes T, Valinsky W, Miquel P, et al. Aldosterone signaling through transient receptor potential melastatin 7 cation channel (TRPM7) and its ?-kinase domain. Cell Signal. 2013;25:2163-75 pubmed publisher..Our findings identify novel mechanisms for non-genomic actions of aldosterone involving differential signaling through MR-activated TRPM7 channel and ?-kinase. ..
- Beyer T, Weiss A, Khomchuk Y, Huang K, Ogunjimi A, Varelas X, et al. Switch enhancers interpret TGF-? and Hippo signaling to control cell fate in human embryonic stem cells. Cell Rep. 2013;5:1611-24 pubmed publisher..These studies define switch-enhancer elements and provide a framework to understand how cellular context dictates interpretation of the same morphogen signal in development. ..
- Landry Truchon K, Houde N, Boucherat O, Joncas F, Dasen J, Philippidou P, et al. HOXA5 plays tissue-specific roles in the developing respiratory system. Development. 2017;144:3547-3561 pubmed publisher..Thus, Hoxa5 possesses tissue-specific functions that differentially contribute to the morphogenesis of the respiratory tract. ..
- Terra R, Louis I, Le Blanc R, Ouellet S, Zuniga Pflucker J, Perreault C. T-cell generation by lymph node resident progenitor cells. Blood. 2005;106:193-200 pubmed..These data provide unique insights into the essence of a primary T-lymphoid organ and into how a cryptic extrathymic T-cell development pathway can be amplified. ..
- Ilangumaran S, Ramanathan S, Ning T, La Rose J, Reinhart B, Poussier P, et al. Suppressor of cytokine signaling 1 attenuates IL-15 receptor signaling in CD8+ thymocytes. Blood. 2003;102:4115-22 pubmed..Because many different cell types express IL-15, our results strongly suggest that SOCS1 functions as an indispensable attenuator of IL-15 receptor signaling in developing CD8+ thymocytes. ..
- Isnard A, Shio M, Olivier M. Impact of Leishmania metalloprotease GP63 on macrophage signaling. Front Cell Infect Microbiol. 2012;2:72 pubmed publisher..In this review article, we are providing a complete overview about the role of Leishmania GP63 in the mechanisms underlying the subversion of macrophage signaling and functions...
- Wang J, Zhang Y, Wang H, Han H, Nattel S, Yang B, et al. Potential mechanisms for the enhancement of HERG K+ channel function by phospholipid metabolites. Br J Pharmacol. 2004;141:586-99 pubmed..The increase in I(HERG) is best described by direct interactions between lipid molecules and HERG proteins, which is consistent with lack of effects via membrane destabilization or modulation by intracellular signaling pathways. ..
- Salins P, Shawesh S, He Y, Dibrov A, Kashour T, Arthur G, et al. Lovastatin protects human neurons against Abeta-induced toxicity and causes activation of beta-catenin-TCF/LEF signaling. Neurosci Lett. 2007;412:211-6 pubmed..Our results suggest that lovastatin protects neuronal cells from Abeta-induced apoptosis and causes reduction in GSK-3beta activity, resulting in activation of Wnt signaling. ..
- Leung Y, Ahmed I, Sheu L, Gao X, Hara M, Tsushima R, et al. Insulin regulates islet alpha-cell function by reducing KATP channel sensitivity to adenosine 5'-triphosphate inhibition. Endocrinology. 2006;147:2155-62 pubmed..This may be an underlying basis for the proposed sequential glucose-insulin regulation of alpha-cell glucagon secretion, which becomes distorted in diabetes, leading to dysregulated glucagon secretion. ..
- Stemerdink C, Jacobs J. Argos and Spitz group genes function to regulate midline glial cell number in Drosophila embryos. Development. 1997;124:3787-96 pubmed..In this manner, midline glia not forming signaling junctions remain sensitive to juxtacrine Argos signaling, while an autocrine Argos signal is excluded by the adhesive junction. ..
- Ratsima H, Serrano D, Pascariu M, D Amours D. Centrosome-Dependent Bypass of the DNA Damage Checkpoint by the Polo Kinase Cdc5. Cell Rep. 2016;14:1422-1434 pubmed publisher..Collectively, our results highlight a previously unappreciated role for centrosomes as key signaling centers for the suppression of cell-cycle arrest induced by persistent or unrepairable DNA damage. ..
- Courboulin A, Paulin R, Giguère N, Saksouk N, Perreault T, Meloche J, et al. Role for miR-204 in human pulmonary arterial hypertension. J Exp Med. 2011;208:535-48 pubmed publisher..This study uncovers a new regulatory pathway involving miR-204 that is critical to the etiology of PAH and indicates that reestablishing miR-204 expression should be explored as a potential new therapy for this disease. ..
- Lambert A, Barabé F, Gilbert C, Tremblay M. DCIR-mediated enhancement of HIV-1 infection requires the ITIM-associated signal transduction pathway. Blood. 2011;117:6589-99 pubmed publisher..Our data suggest for the first time an involvement of ITIM domain in HIV-1-mediated signaling events and a relationship between phosphorylation events and DCIR function with respect to HIV-1 biology. ..
- Devost D, Sleno R, PÃ©trin D, Zhang A, Shinjo Y, Okde R, et al. Conformational Profiling of the AT1 Angiotensin II Receptor Reflects Biased Agonism, G Protein Coupling, and Cellular Context. J Biol Chem. 2017;292:5443-5456 pubmed publisher..Our study provides mechanistic insights into signaling events that depend on either G proteins or Î²-arrestin. ..
- Sarfati M, Fortin G, Raymond M, Susin S. CD47 in the immune response: role of thrombospondin and SIRP-alpha reverse signaling. Curr Drug Targets. 2008;9:842-50 pubmed..We thus propose CD47/TSP-1/SIRP-alpha axis as an important sensor to maintain homeostasis and regulate innate and adaptive immune responses. ..
- Jin T, George Fantus I, Sun J. Wnt and beyond Wnt: multiple mechanisms control the transcriptional property of beta-catenin. Cell Signal. 2008;20:1697-704 pubmed publisher..These observations provide new insight to understand how Wnt, insulin/growth factors, and FOXOs are involved in versatile physiological events and the development and progression of various human diseases. ..
- Kozlowski M, Larose L, Lee F, Le D, Rottapel R, Siminovitch K. SHP-1 binds and negatively modulates the c-Kit receptor by interaction with tyrosine 569 in the c-Kit juxtamembrane domain. Mol Cell Biol. 1998;18:2089-99 pubmed
- Voisin L, Foisy S, Giasson E, Lambert C, Moreau P, Meloche S. EGF receptor transactivation is obligatory for protein synthesis stimulation by G protein-coupled receptors. Am J Physiol Cell Physiol. 2002;283:C446-55 pubmed..Our results demonstrate that EGFR transactivation is a physiologically relevant action of GPCRs linked to translational control and protein synthesis. ..
- Antoine Bertrand J, Ghogha A, Luangrath V, Bedford F, Lamarche Vane N. The activation of ezrin-radixin-moesin proteins is regulated by netrin-1 through Src kinase and RhoA/Rho kinase activities and mediates netrin-1-induced axon outgrowth. Mol Biol Cell. 2011;22:3734-46 pubmed publisher..Together, our findings demonstrate that netrin-1 induces the formation of an activated ERM/DCC complex in growth cone filopodia, which is required for netrin-1-dependent cortical axon outgrowth. ..