Genomes and Genes
Experts and Doctors on sequence alignment in United States
Locale: United States
Topic: sequence alignment
Publications758 found, 100 shown here
- Canatan H, Lin Y. Molecular cloning and sequence analysis of canine acidic ribosomal phosphoprotein P0 cDNA. DNA Seq. 2000;11:321-6 pubmed..Canine ARP0 cDNA and their deduced amino acid sequences share very high homology to ARP0 orthologs from other vertebrate species including human, mouse, rat, chicken, and bovine. ..
- Rontein D, Wu W, Voelker D, Hanson A. Mitochondrial phosphatidylserine decarboxylase from higher plants. Functional complementation in yeast, localization in plants, and overexpression in Arabidopsis. Plant Physiol. 2003;132:1678-87 pubmed..They also indicate that mitochondrial PSD is an important housekeeping enzyme whose expression is strongly regulated at the transcriptional level. ..
- Baker C, Sieber P, Wellmer F, Meyerowitz E. The early extra petals1 mutant uncovers a role for microRNA miR164c in regulating petal number in Arabidopsis. Curr Biol. 2005;15:303-15 pubmed
- Wu Z, Yan N, Feng L, Oberstein A, Yan H, Baker R, et al. Structural analysis of a rhomboid family intramembrane protease reveals a gating mechanism for substrate entry. Nat Struct Mol Biol. 2006;13:1084-91 pubmed..Structural analysis suggests that substrate entry to the active site is probably gated by the movement of helix alpha5. ..
- Dombrink Kurtzman M. A gene having sequence homology to isoamyl alcohol oxidase is transcribed during patulin production in Penicillium griseofulvum. Curr Microbiol. 2008;56:224-8 pubmed..The amplified products were sequenced for confirmation of their identities. This is the first report of an isoamyl alcohol oxidase gene in a species of the genus Penicillium. ..
- Das S, Bhat P, Sudhakar C, Ehlers J, Wanamaker S, Roberts P, et al. Detection and validation of single feature polymorphisms in cowpea (Vigna unguiculata L. Walp) using a soybean genome array. BMC Genomics. 2008;9:107 pubmed publisher..This study provides an example of extension of genomic resources from a well supported species to an orphan crop. Presumably, other legume systems are similarly tractable to SFP marker development using existing legume array resources. ..
- May M, Brown D. Genetic variation in sialidase and linkage to N-acetylneuraminate catabolism in Mycoplasma synoviae. Microb Pathog. 2008;45:38-44 pubmed publisher..Retention of nanI by such strains, but not others in the M. synoviae phylogenetic cluster, is evidence that sialidase has an important non-nutritional role in the ecology of M. synoviae and certain other mycoplasmas. ..
- Francis P, Appukuttan B, Simmons E, Landauer N, Stoddard J, Hamon S, et al. Rhesus monkeys and humans share common susceptibility genes for age-related macular disease. Hum Mol Genet. 2008;17:2673-80 pubmed publisher..This is the first evidence that humans and macaques share the same genetic susceptibility factors for a common complex disease. ..
- Snyder D, Aramini J, Yu B, Huang Y, Xiao R, Cort J, et al. Solution NMR structure of the ribosomal protein RP-L35Ae from Pyrococcus furiosus. Proteins. 2012;80:1901-6 pubmed publisher..The structure of the P. furiosus RP-L35Ae presented in this article constitutes the first structural representative from this protein domain family. ..
- Sturm R, Sheynkman G, Booth C, Smith L, Pedersen J, Li L. Absolute quantification of prion protein (90-231) using stable isotope-labeled chymotryptic peptide standards in a LC-MRM AQUA workflow. J Am Soc Mass Spectrom. 2012;23:1522-33 pubmed publisher..To the authors' knowledge, this is the first report on the use of a non-tryptic peptide in a LC-MRM AQUA workflow. ..
- Tseng Y, Liao G, Sen G, Lin F, Hsu W. Regulation of PACT-Mediated Protein Kinase Activation by the OV20.0 Protein of Orf Virus. J Virol. 2015;89:11619-29 pubmed publisher..Finally, OV20.0 associates with PACT via the RBDs, which may reduce the ability of PACT to induce PKR activation. The findings in this study provide new concepts in relation to how ORFV modulates PKR activation. ..
- Mueller P, Coleman T, Dunphy W. Cell cycle regulation of a Xenopus Wee1-like kinase. Mol Biol Cell. 1995;6:119-34 pubmed..These studies indicate that the down-regulation of Wee1-like kinase activity at mitosis is a multistep process that occurs after other biochemical reactions have signaled the successful completion of S phase. ..
- Shartzer K, Kage K, Sobieski R, Andrews G. Evolution of avian metallothionein: DNA sequence analyses of the turkey metallothionein gene and metallothionein cDNAs from pheasant and quail. J Mol Evol. 1993;36:255-62 pubmed..The results suggest the existence of a single MT mRNA in zinc-treated liver from turkey and pheasant and the existence of a major and possibly a minor MT mRNA in quail.(ABSTRACT TRUNCATED AT 250 WORDS) ..
- Semple Rowland S, Gorczyca W, Buczylko J, Helekar B, Ruiz C, Subbaraya I, et al. Expression of GCAP1 and GCAP2 in the retinal degeneration (rd) mutant chicken retina. FEBS Lett. 1996;385:47-52 pubmed
- Mulcahy R, Wartman M, Bailey H, Gipp J. Constitutive and beta-naphthoflavone-induced expression of the human gamma-glutamylcysteine synthetase heavy subunit gene is regulated by a distal antioxidant response element/TRE sequence. J Biol Chem. 1997;272:7445-54 pubmed..Collectively the data indicate that the constitutive and beta-NF-induced expression of the human GCS heavy subunit gene is mediated by a distal ARE sequence containing an embedded tetradecanoylphorbol-13-acetate-responsive element. ..
- Ying Z, Mulligan R, Janney N, Houtz R. Rubisco small and large subunit N-methyltransferases. Bi- and mono-functional methyltransferases that methylate the small and large subunits of Rubisco. J Biol Chem. 1999;274:36750-6 pubmed..Thus, the absence of lysine-14 methylation in species like spinach is apparently a consequence of a monofunctional protein methyltransferase incapable of methylating Lys-14, with activity limited to methylation of the SS...
- Jones G, Jones D, Zhou L, Steller H, Chu Y. Deterin, a new inhibitor of apoptosis from Drosophila melanogaster. J Biol Chem. 2000;275:22157-65 pubmed..Whereas the nematode survivin-type IAP has thus far been implicated only as a mitotic regulator, Drosophila deterin constitutes the first invertebrate member of the survivin-type IAP group to exhibit apoptosis-inhibitory activity. ..
- Nishiwaki E, Turner S, Harju S, Miyazaki S, Kashiwagi M, Koh J, et al. Regulation of CDK7-carboxyl-terminal domain kinase activity by the tumor suppressor p16(INK4A) contributes to cell cycle regulation. Mol Cell Biol. 2000;20:7726-34 pubmed..Regulation of CDK7-CTD kinase activity by p16(INK4A) thus may represent an alternative pathway for controlling cell cycle progression. ..
- Hong Z, Zhang Z, Olson J, Verma D. A novel UDP-glucose transferase is part of the callose synthase complex and interacts with phragmoplastin at the forming cell plate. Plant Cell. 2001;13:769-79 pubmed..We propose that UGT1 may transfer UDP-glucose from sucrose synthase to the callose synthase and thus help form a substrate channel for the synthesis of callose at the forming cell plate...
- Meng G, Wei X, Wu X, Sellers M, Decker J, Moldoveanu Z, et al. Primary intestinal epithelial cells selectively transfer R5 HIV-1 to CCR5+ cells. Nat Med. 2002;8:150-6 pubmed..Our finding that CCR5+ intestinal epithelial cells select and transfer exclusively R5 viruses indicates a mechanism for the selective transmission of R5 HIV-1 in primary infection acquired through the upper gastrointestinal tract. ..
- Springer N, Danilevskaya O, Hermon P, Helentjaris T, Phillips R, Kaeppler H, et al. Sequence relationships, conserved domains, and expression patterns for maize homologs of the polycomb group genes E(z), esc, and E(Pc). Plant Physiol. 2002;128:1332-45 pubmed..The conservation of E(z) and esc homologs across kingdoms indicates that these genes likely play a conserved role in repressing gene expression. ..
- Li H, Gailbreath K, Bender L, West K, Keller J, Crawford T. Evidence of three new members of malignant catarrhal fever virus group in muskox (Ovibos moschatus), Nubian ibex (Capra nubiana), and gemsbok (Oryx gazella). J Wildl Dis. 2003;39:875-80 pubmed..3% identity). The viral sequence in the gemsbok is most closely related to AlHV-1 (85.1% identity). No evidence of disease association with these viruses has been found...
- Hajdu Cronin Y, Chen W, Sternberg P. The L-type cyclin CYL-1 and the heat-shock-factor HSF-1 are required for heat-shock-induced protein expression in Caenorhabditis elegans. Genetics. 2004;168:1937-49 pubmed..hsf-1 encodes the C. elegans homolog of the human heat-shock factor HSF1, and cyl-1 encodes a cyclin most similar to cyclin L. We believe HSF-1 acts in heat-shock-inducible transcription and CYL-1 acts more generally in gene expression. ..
- Dixit R, Arakane Y, Specht C, Richard C, Kramer K, Beeman R, et al. Domain organization and phylogenetic analysis of proteins from the chitin deacetylase gene family of Tribolium castaneum and three other species of insects. Insect Biochem Mol Biol. 2008;38:440-51 pubmed publisher..Most of the CDA-like proteins have a putative signal peptide consistent with their role in modifying extracellular chitin in both cuticle and peritrophic membrane during morphogenesis and molting. ..
- Jagadeeswaran G, Zheng Y, Sumathipala N, Jiang H, Arrese E, Soulages J, et al. Deep sequencing of small RNA libraries reveals dynamic regulation of conserved and novel microRNAs and microRNA-stars during silkworm development. BMC Genomics. 2010;11:52 pubmed publisher..We identified 101 homologs of conserved miRNAs, 14 species-specific and two antisense miRNAs in the silkworm. Our results provided deeper insights into changes in conserved and novel miRNA and miRNA* accumulation during development. ..
- Heustis R, Ng H, Brand K, Rogers M, Le L, Specht C, et al. Pharyngeal polysaccharide deacetylases affect development in the nematode C. elegans and deacetylate chitin in vitro. PLoS ONE. 2012;7:e40426 pubmed publisher..elegans pharynx. Our results suggest that one function of PDAs in nematodes may be deacetylation of the chitinous pharyngeal lining. ..
- Mitra M, Hercík K, Byeon I, Ahn J, Hill S, Hinchee Rodriguez K, et al. Structural determinants of human APOBEC3A enzymatic and nucleic acid binding properties. Nucleic Acids Res. 2014;42:1095-110 pubmed publisher..Taken together, our studies provide new insights into the molecular properties of A3A and its role in multiple cellular and antiviral functions. ..
- Liang F, Kroon G, McAvoy C, Chi C, Wright P, Shan S. Conformational dynamics of a membrane protein chaperone enables spatially regulated substrate capture and release. Proc Natl Acad Sci U S A. 2016;113:E1615-24 pubmed publisher..Our work demonstrates how the intrinsic conformational dynamics of a chaperone enables spatially coordinated substrate capture and release, which may be general to other ATP-independent chaperone systems. ..
- Filippov V, Solovyev V, Filippova M, Gill S. A novel type of RNase III family proteins in eukaryotes. Gene. 2000;245:213-21 pubmed..A potential drosha homologue is also found among the deposited human cDNA sequences. A comparison of these drosha proteins to other members of the RNase III family indicates that they form a new group of proteins within this family. ..
- Kostichka K, Tao L, Bramucci M, Tomb J, Nagarajan V, Cheng Q. A small cryptic plasmid from Rhodococcus erythropolis: characterization and utility for gene expression. Appl Microbiol Biotechnol. 2003;62:61-8 pubmed..Expression of an isoprenoid pathway gene ( dxs) on the pAN12-derived multicopy shuttle vector increased production of carotenoid pigments in R. erythropolis ATCC 47072. ..
- Bhardwaj A, Walker Kopp N, Casjens S, Cingolani G. An evolutionarily conserved family of virion tail needles related to bacteriophage P22 gp26: correlation between structural stability and length of the alpha-helical trimeric coiled coil. J Mol Biol. 2009;391:227-45 pubmed publisher..Thus, the overall stability of these bacteriophage fibers is not solely dependent on the number of trimerization repeats in the alpha-helical core. ..
- Kayyem J, Roman J, de la Rosa E, Schwarz U, Dreyer W. Bravo/Nr-CAM is closely related to the cell adhesion molecules L1 and Ng-CAM and has a similar heterodimer structure. J Cell Biol. 1992;118:1259-70 pubmed
- Bullard D, Schimenti J. Molecular structure of Tcp-10 genes from the t complex responder locus. Mamm Genome. 1991;1:228-34 pubmed..However, no major sequence differences were found within the coding sequence to conclude that Tcp-10pst is a pseudogene. ..
- Dangel A, Mendoza A, Baker B, Daniel C, Carroll M, Wu L, et al. The dichotomous size variation of human complement C4 genes is mediated by a novel family of endogenous retroviruses, which also establishes species-specific genomic patterns among Old World primates. Immunogenetics. 1994;40:425-36 pubmed..It is possible that members of HERV-K(C4) are involved in genetic instabilities including the RCCX modules, and in protecting the host genome from retroviral attack through an antisense strategy. ..
- MacLennan A, Browe C, Gaskin A, Lado D, Shaw G. Cloning and characterization of a putative G-protein coupled receptor potentially involved in development. Mol Cell Neurosci. 1994;5:201-9 pubmed..Finally, all of the sequence motifs characteristic of Src homology 2 domains are present in pH218 but in a unique arrangement. We conclude that pH218 may function as a growth factor receptor. ..
- Liang S, Hitomi M, Hu Y, Liu Y, Tartakoff A. A DEAD-box-family protein is required for nucleocytoplasmic transport of yeast mRNA. Mol Cell Biol. 1996;16:5139-46 pubmed..Critical residues of Mtr4p, including the mtr4-1 point mutation, have been identified. Mtr4p may serve as a chaperone which translocates or normalizes the structure of mRNAs in preparation for export. ..
- Lyman S, Escobar S, Rousseau A, Armstrong A, Fanslow W. Identification of CD7 as a cognate of the human K12 (SECTM1) protein. J Biol Chem. 2000;275:3431-7 pubmed..Human K12-Fc stimulated the up-regulation of CD25, CD54, and CD69 on human NK cells in vitro. ..
- Ogura K, Choudhuri S, Klaassen C. Full-length cDNA cloning and genomic organization of the mouse liver-specific organic anion transporter-1 (lst-1). Biochem Biophys Res Commun. 2000;272:563-70 pubmed
- Rocha E, Owens G, Smith C. The redox-sensitive transcriptional activator OxyR regulates the peroxide response regulon in the obligate anaerobe Bacteroides fragilis. J Bacteriol. 2000;182:5059-69 pubmed..Analysis of oxyR expression in the parents and in DeltaoxyR and overexpressing oxyR strains by Northern blotting and oxyR'::xylB fusions revealed that B. fragilis OxyR does not control its own expression...
- Palmer C, Zhou X, Lin J, Loukin S, Kung C, Saimi Y. A TRP homolog in Saccharomyces cerevisiae forms an intracellular Ca(2+)-permeable channel in the yeast vacuolar membrane. Proc Natl Acad Sci U S A. 2001;98:7801-5 pubmed..This report has implications for the function of TRP channels in other organisms and the possible molecular identification of vacuolar/lysosomal ion channels in other eukaryotes. ..
- Hotzel I, Cheevers W. Host range of small-ruminant lentivirus cytopathic variants determined with a selectable caprine arthritis- encephalitis virus pseudotype system. J Virol. 2001;75:7384-91 pubmed..The results indicate a differential receptor recognition by MVV strains which is unrelated to cytopathic phenotype...
- Addlagatta A, Hu X, Liu J, Matthews B. Structural basis for the functional differences between type I and type II human methionine aminopeptidases. Biochemistry. 2005;44:14741-9 pubmed..Also, the N-terminal region of the protein contains three distinct Pro-x-x-Pro motifs, supporting the prior suggestion that this region of the protein may participate in binding to the ribosome. ..
- Parish D, Benach J, Liu G, Singarapu K, Xiao R, Acton T, et al. Protein chaperones Q8ZP25_SALTY from Salmonella typhimurium and HYAE_ECOLI from Escherichia coli exhibit thioredoxin-like structures despite lack of canonical thioredoxin active site sequence motif. J Struct Funct Genomics. 2008;9:41-9 pubmed publisher..The structures presented here exhibit the expected thioredoxin-like fold and support the view that members of Pfam family PF07449 specifically interact with Tat signal peptides. ..
- Li S, Lian S, Moser J, Fritzler M, Fritzler M, Satoh M, et al. Identification of GW182 and its novel isoform TNGW1 as translational repressors in Ago2-mediated silencing. J Cell Sci. 2008;121:4134-44 pubmed publisher..Our data demonstrated that GW182 and, probably, TNGW1 acted as a repressor in Ago2-mediated translational silencing. Furthermore, TNGW1 might contribute to diversity in the formation and function of GW and/or P bodies. ..
- Rissman A, Mau B, Biehl B, Darling A, Glasner J, Perna N. Reordering contigs of draft genomes using the Mauve aligner. Bioinformatics. 2009;25:2071-3 pubmed publisher..The software is available for download at http://gel.ahabs.wisc.edu/mauve. ..
- Bridgham J, Ortlund E, Thornton J. An epistatic ratchet constrains the direction of glucocorticoid receptor evolution. Nature. 2009;461:515-9 pubmed publisher..Our findings indicate that even if selection for the ancestral function were imposed, direct reversal would be extremely unlikely, suggesting an important role for historical contingency in protein evolution. ..
- Reineke L, Merrick W. Characterization of the functional role of nucleotides within the URE2 IRES element and the requirements for eIF2A-mediated repression. RNA. 2009;15:2264-77 pubmed publisher..These data provide valuable insights into the mRNA requirements for internal initiation in yeast, and insights into the mechanism of eIF2A-mediated suppression. ..
- Vinje M, Willis D, Duke S, Henson C. Differential expression of two ?-amylase genes (Bmy1 and Bmy2) in developing and mature barley grain. Planta. 2011;233:1001-10 pubmed publisher..However, Bmy1 protein was far more prevalent than Bmy2 at all developmental stages in all genotypes. Thus, the vast majority of ?-amylase activity in developing and mature grain can be attributed to endosperm-specific ?-amylase...
- Ortega M, Kurian J, McKenna R, Hansen P. Characteristics of candidate genes associated with embryonic development in the cow: Evidence for a role for WBP1 in development to the blastocyst stage. PLoS ONE. 2017;12:e0178041 pubmed publisher..WBP1 is an important gene for embryonic development in the cow. Further research to identify how the SNP in WBP1 affects processes leading to differentiation of the embryo into TE and ICM lineages is warranted. ..
- Liu Z, Li P, Dunham R. Characterization of an A/T-rich family of sequences from channel catfish (Ictalurus punctatus). Mol Mar Biol Biotechnol. 1998;7:232-9 pubmed..Many features of these elements could make them potentially important for development of homologous recombination expression vectors and position-independent expression vectors...
- Lashbrook C, Tieman D, Klee H. Differential regulation of the tomato ETR gene family throughout plant development. Plant J. 1998;15:243-52 pubmed..Furthermore, the abundance of mRNAs for all three LeETR genes remained uniform in multiple plant tissues experiencing marked changes in ethylene sensitivity, including the cell separation layer throughout tomato flower abscission. ..
- Parente J, Chen X, Zhou C, Petropoulos A, Chew C. Isolation, cloning, and characterization of a new mammalian coronin family member, coroninse, which is regulated within the protein kinase C signaling pathway. J Biol Chem. 1999;274:3017-25 pubmed..We have tentatively named this protein coroninse, because it appears to be highly expressed in secretory epithelia. ..
- Ma J, Zhang D, Laser M, Brownlee N, Re G, Hazen Martin D, et al. Identification of RPE65 in transformed kidney cells. FEBS Lett. 1999;452:199-204 pubmed..These results demonstrated that transformed kidney cells express this retinoid processing protein, suggesting that these transformed cells may have an alternative retinoid metabolism not present in normal kidney cells. ..
- Chessler S, Simonson W, Sweet I, Hammerle L. Expression of the vesicular inhibitory amino acid transporter in pancreatic islet cells: distribution of the transporter within rat islets. Diabetes. 2002;51:1763-71 pubmed..The rat islet mantle differs from rat and human beta-cells in that it contains only GAD67 and relatively increased levels of VIAAT. Cells that express only GAD67 may require higher levels of VIAAT expression. ..
- Goellner G, DeMarco S, Strehler E. Characterization of PISP, a novel single-PDZ protein that binds to all plasma membrane Ca2+-ATPase b-splice variants. Ann N Y Acad Sci. 2003;986:461-71 pubmed..Our data suggest that PISP is a transiently interacting partner of the PMCA b-splice forms that may play a role in their sorting to or from the plasma membrane. ..
- Yoo H, Kumagai A, Shevchenko A, Shevchenko A, Dunphy W. Ataxia-telangiectasia mutated (ATM)-dependent activation of ATR occurs through phosphorylation of TopBP1 by ATM. J Biol Chem. 2007;282:17501-6 pubmed..Thus, TopBP1 is critical for the ATM-dependent activation of ATR following production of DSBs in the genome. ..
- Wellehan J, Childress A, Marschang R, Johnson A, Lamirande E, Roberts J, et al. Consensus nested PCR amplification and sequencing of diverse reptilian, avian, and mammalian orthoreoviruses. Vet Microbiol. 2009;133:34-42 pubmed publisher..This PCR method may be useful for obtaining templates for initial sequencing of novel orthoreoviruses from diverse vertebrate hosts...
- Seo G, Fink L, O HARA B, Atwood W, Sullivan C. Evolutionarily conserved function of a viral microRNA. J Virol. 2008;82:9823-8 pubmed publisher..Furthermore, we show that these miRNAs are expressed in individuals diagnosed with polyomavirus-associated disease, suggesting their potential as targets for therapeutic intervention. ..
- Ayme Southgate A, Philipp R, Southgate R. Projectin PEVK domain, splicing variants and domain structure in basal and derived insects. Insect Mol Biol. 2011;20:347-56 pubmed publisher..The analysis of alternative splicing variants identifies the shortest PEVK isoform as the predominant form in the flight muscles of several insects, possibly contributing to myofibrillar stiffness...
- Rani M, Bolles M, Donaldson E, Van Blarcom T, Baric R, Iverson B, et al. Increased antibody affinity confers broad in vitro protection against escape mutants of severe acute respiratory syndrome coronavirus. J Virol. 2012;86:9113-21 pubmed publisher..Collectively, these results support the hypothesis that engineered antibodies with picomolar dissociation constants for a neutralizing epitope can confer escape-resistant protection...
- Mohan R, Dialynas G, Weake V, Liu J, Martin Brown S, Florens L, et al. Loss of Drosophila Ataxin-7, a SAGA subunit, reduces H2B ubiquitination and leads to neural and retinal degeneration. Genes Dev. 2014;28:259-72 pubmed publisher..When we examined the consequences of reduced Ataxin-7 in vivo, we found that flies exhibited pronounced neural and retinal degeneration, impaired movement, and early lethality...
- de la Fuente J, Garcia Garcia J, Blouin E, Rodriguez S, Garcia M, Kocan K. Evolution and function of tandem repeats in the major surface protein 1a of the ehrlichial pathogen Anaplasma marginale. Anim Health Res Rev. 2001;2:163-73 pubmed..These repeated sequences include markers for tick transmissibility that may be important in the identification of ehrlichial pathogens because they may influence control strategies and the design of subunit vaccines...
- Gui C, Hagenbuch B. Amino acid residues in transmembrane domain 10 of organic anion transporting polypeptide 1B3 are critical for cholecystokinin octapeptide transport. Biochemistry. 2008;47:9090-7 pubmed publisher..In conclusion, we have identified three amino acid residues (Y537, S545, and T550) in TM10 of OATP1B3 that are important for CCK-8 transport. ..
- Chen J, Gibson J, McCue L, Tabita F. Identification, expression, and deduced primary structure of transketolase and other enzymes encoded within the form II CO2 fixation operon of Rhodobacter sphaeroides. J Biol Chem. 1991;266:20447-52 pubmed..Each of the genes are separated by short stretches of intergenic sequence, consistent with earlier evidence which suggested that these genes are cotranscribed and part of a large operon controlled by sequences upstream from fbpB. ..
- Ma G, Hong Y, Ives D. Cloning and expression of the heterodimeric deoxyguanosine kinase/deoxyadenosine kinase of Lactobacillus acidophilus R-26. J Biol Chem. 1995;270:6595-601 pubmed..dGK also shares a sequence (-Y-D-P-T-I/L-E-D-S/Y-Y-) required for GTP hydrolysis by p21ras. ..
- Blok L, Grossmann M, Perry J, Tindall D. Characterization of an early growth response gene, which encodes a zinc finger transcription factor, potentially involved in cell cycle regulation. Mol Endocrinol. 1995;9:1610-20 pubmed..These results indicated that the zinc finger transcription factor EGR alpha seems to play a role in cell cycle regulation. ..
- Hamilton T, Flynn G. Cer1p, a novel Hsp70-related protein required for posttranslational endoplasmic reticulum translocation in yeast. J Biol Chem. 1996;271:30610-3 pubmed..CER1 is predicted to encode a 100-kDa polypeptide, residing in the ER lumen that is related to the hsp70 family of molecular chaperones. ..
- Plager D, Loegering D, Weiler D, Checkel J, Wagner J, Clarke N, et al. A novel and highly divergent homolog of human eosinophil granule major basic protein. J Biol Chem. 1999;274:14464-73 pubmed..Overall, this novel homolog's unique physical properties indicated that the high net positive charge of hMBP is important but not essential for biological activity. ..
- Ghosh D, Crane B, Ghosh S, Wolan D, Gachhui R, Crooks C, et al. Inducible nitric oxide synthase: role of the N-terminal beta-hairpin hook and pterin-binding segment in dimerization and tetrahydrobiopterin interaction. EMBO J. 1999;18:6260-70 pubmed..This suggests a mechanism whereby N-terminal hooks exchange between subunits in solution to stabilize the dimer. ..
- Micoli K, Pan G, Wu Y, Williams J, Cook W, McDonald J. Requirement of calmodulin binding by HIV-1 gp160 for enhanced FAS-mediated apoptosis. J Biol Chem. 2000;275:1233-40 pubmed..The data indicate that gp160-enhanced apoptosis is dependent upon calmodulin up-regulation, involves the activation of caspase 3, and requires calmodulin binding to the C-terminal binding domain of gp160. ..
- Payne C, Zhang F, Lloyd A. GL3 encodes a bHLH protein that regulates trichome development in arabidopsis through interaction with GL1 and TTG1. Genetics. 2000;156:1349-62 pubmed..These data suggest a reiterated combinatorial model for the differential regulation of such diverse developmental pathways as trichome cell-fate determination, root hair spacing, and anthocyanin secondary metabolism. ..
- Butchbach M, Lai L, Lin C. Molecular cloning, gene structure, expression profile and functional characterization of the mouse glutamate transporter (EAAT3) interacting protein GTRAP3-18. Gene. 2002;292:81-90 pubmed..Mouse GTRAP3-18 inhibited EAAT3-mediated glutamate transport in a dose-dependent manner. These studies show that GTRAP3-18 is a ubiquitously expressed protein that functions as a negative regulator of EAAT3 function. ..
- Cherbas L, Hu X, Zhimulev I, Belyaeva E, Cherbas P. EcR isoforms in Drosophila: testing tissue-specific requirements by targeted blockade and rescue. Development. 2003;130:271-84 pubmed..In light of our results, the simplest explanations for the widespread spatial and temporal variations in EcR isoform titers appear untenable. ..
- Pandrea I, Mittleider D, Brindley P, Didier E, Robertson D. Phylogenetic relationships of methionine aminopeptidase 2 among Encephalitozoon species and genotypes of microsporidia. Mol Biochem Parasitol. 2005;140:141-52 pubmed
- Conner J, Beisswenger P, Szwergold B. Some clues as to the regulation, expression, function, and distribution of fructosamine-3-kinase and fructosamine-3-kinase-related protein. Ann N Y Acad Sci. 2005;1043:824-36 pubmed..These data suggest that FN3K and FN3KRP are constitutive "housekeeping" genes and that they play an important role in cell metabolism, possibly as deglycating enzymes. ..
- Zhu Y, Li H, Miller D, Wang Z, Xuan J, Clarke R, et al. caBIG VISDA: modeling, visualization, and discovery for cluster analysis of genomic data. BMC Bioinformatics. 2008;9:383 pubmed publisher..VISDA also captured the pathological relationships among different phenotypes revealed at the molecular level, through phenotype clustering on muscular dystrophy data and multi-category cancer data. ..
- Ye Y, Tang H. An ORFome assembly approach to metagenomics sequences analysis. J Bioinform Comput Biol. 2009;7:455-71 pubmed..This improvement is especially useful for metagenomic projects when the genome assembly does not work because of the low sequence coverage. ..
- Zakon H, Jost M, Zwickl D, Lu Y, Hillis D. Molecular evolution of Na+ channels in teleost fishes. Integr Zool. 2009;4:64-74 pubmed publisher..The enhanced rate of sequence evolution of this gene likely underlies the species-level variations in the electric signal. ..
- Ahn J, Oh S, Suh Y, Moeller S, Lee K. Porcine G?/G? switch gene 2 (G0S2) expression is regulated during adipogenesis and short-term in-vivo nutritional interventions. Lipids. 2013;48:209-18 pubmed publisher..Therefore, porcine G0S2, which is both a negative regulator of ATGL-mediated lipolysis and cell proliferation in adipose tissue, can be down-regulated in vivo by a short-term 24-h fast followed by increased ATGL-mediated lipolysis. ..
- Janaka S, Gregory D, Johnson M. Retrovirus glycoprotein functionality requires proper alignment of the ectodomain and the membrane-proximal cytoplasmic tail. J Virol. 2013;87:12805-13 pubmed publisher..We hypothesize that the CTD forms a coiled-coil that disrupts the protein's functionality if it is not in phase with the trimer interface of the ectodomain...
- Sambrotta M, Strautnieks S, Papouli E, Rushton P, Clark B, Parry D, et al. Mutations in TJP2 cause progressive cholestatic liver disease. Nat Genet. 2014;46:326-8 pubmed publisher..These findings contrast with those in the embryonic-lethal knockout mouse, highlighting differences in redundancy in junctional complexes between organs and species. ..
- Rhine J, Taylor R. TcpA pilin sequences and colonization requirements for O1 and O139 vibrio cholerae. Mol Microbiol. 1994;13:1013-20 pubmed..abstract truncated at 250 words)..
- Greig G, Sharp C, Carrel L, Willard H. Duplicated zinc finger protein genes on the proximal short arm of the human X chromosome: isolation, characterization and X-inactivation studies. Hum Mol Genet. 1993;2:1611-8 pubmed..Furthermore, under conditions of lowered stringency, additional bands are seen in several species, suggesting that the two genes reported here may be members of a larger zinc finger gene family. ..
- Hornstra I, Nelson D, Warren S, Yang T. High resolution methylation analysis of the FMR1 gene trinucleotide repeat region in fragile X syndrome. Hum Mol Genet. 1993;2:1659-65 pubmed..abstract truncated at 250 words) ..
- LeBoeuf R, Caldwell M, Guo Y, Metz C, Davitz M, Olson L, et al. Mouse glycosylphosphatidylinositol-specific phospholipase D (Gpld1) characterization. Mamm Genome. 1998;9:710-4 pubmed..This is the first report of map position and genetic regulation for Gpld1. This information will enable us to further study the expression and function of GPI-PLD in normal and pathological conditions. ..
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