Genomes and Genes
Experts and Doctors on schwann cells in Italy
Topic: schwann cells
- Magnaghi V, Procacci P, Tata A. Chapter 15: Novel pharmacological approaches to Schwann cells as neuroprotective agents for peripheral nerve regeneration. Int Rev Neurobiol. 2009;87:295-315 pubmed publisher..In this review, we survey the latest findings on these factors and assess their potential as novel promising treatments for peripheral neuropathies caused by injury. ..
- Benito C, Davis C, Gomez Sanchez J, Turmaine M, Meijer D, Poli V, et al. STAT3 Controls the Long-Term Survival and Phenotype of Repair Schwann Cells during Nerve Regeneration. J Neurosci. 2017;37:4255-4269 pubmed publisher..Defining the molecular mechanisms that maintain repair Schwann cells is an essential step toward developing therapeutic strategies that improve nerve regeneration and functional recovery. ..
- Rocco E, Iannuzzi F, Dell Era A, Falleni M, Moneghini L, Di Nuovo F, et al. Schwann cell hamartoma: case report. BMC Gastroenterol. 2011;11:68 pubmed publisher..As recently proposed, this lesion was finally described as mucosal Schwann cell hamartoma. ..
- Bolis A, Zordan P, Coviello S, Bolino A. Myotubularin-related (MTMR) phospholipid phosphatase proteins in the peripheral nervous system. Mol Neurobiol. 2007;35:308-16 pubmed..In this review, we will discuss recent findings on the MTMR family with a major focus on MTMR2 and MTMR13 and their putative role in Schwann cell biology. ..
- Occhi S, Zambroni D, Del Carro U, Amadio S, Sirkowski E, Scherer S, et al. Both laminin and Schwann cell dystroglycan are necessary for proper clustering of sodium channels at nodes of Ranvier. J Neurosci. 2005;25:9418-27 pubmed..Finally, abnormal sodium channel clusters are present in a patient with MDC1A, providing a molecular basis for the reduced nerve conduction velocity in this disorder. ..
- Court F, Zambroni D, Pavoni E, Colombelli C, Baragli C, Figlia G, et al. MMP2-9 cleavage of dystroglycan alters the size and molecular composition of Schwann cell domains. J Neurosci. 2011;31:12208-17 pubmed publisher..Thus, regulated cleavage may be a general mechanism to regulate protein complex composition in physiological conditions, whereas unregulated processing is pathogenic and a target for treatment in disease. ..
- Perego C, Di Cairano E, Ballabio M, Magnaghi V. Neurosteroid allopregnanolone regulates EAAC1-mediated glutamate uptake and triggers actin changes in Schwann cells. J Cell Physiol. 2012;227:1740-51 pubmed publisher..Glutamate transporters may represent a potential therapeutic target to control Schwann cell physiology. ..
- La Marca R, Cerri F, Horiuchi K, Bachi A, Feltri M, Wrabetz L, et al. TACE (ADAM17) inhibits Schwann cell myelination. Nat Neurosci. 2011;14:857-65 pubmed publisher..Thus, TACE is a modulator of NRG1 type III activity and is a negative regulator of myelination in the PNS. ..
- Vaccari I, Dina G, Tronchère H, Kaufman E, Chicanne G, Cerri F, et al. Genetic interaction between MTMR2 and FIG4 phospholipid phosphatases involved in Charcot-Marie-Tooth neuropathies. PLoS Genet. 2011;7:e1002319 pubmed publisher..Reduction of Fig4 by null heterozygosity and downregulation of PIKfyve both rescue Mtmr2-null myelin outfoldings in vivo and in vitro. ..
- Nodari A, Previtali S, Dati G, Occhi S, Court F, Colombelli C, et al. Alpha6beta4 integrin and dystroglycan cooperate to stabilize the myelin sheath. J Neurosci. 2008;28:6714-9 pubmed publisher..These data indicate that, similar to its role in skin, alpha6beta4 integrin confers stability to myelin in peripheral nerves. ..
- Triolo D, Dina G, Taveggia C, Vaccari I, Porrello E, Rivellini C, et al. Vimentin regulates peripheral nerve myelination. Development. 2012;139:1359-67 pubmed publisher..Our results reveal a novel role for the intermediate filament vimentin in myelination, and indicate vimentin as a regulator of NRG1 type III function. ..
- Geuna S, Nicolino S, Raimondo S, Gambarotta G, Battiston B, Tos P, et al. Nerve regeneration along bioengineered scaffolds. Microsurgery. 2007;27:429-38 pubmed
- Noseda R, Guerrero Valero M, Alberizzi V, Previtali S, Sherman D, Palmisano M, et al. Kif13b Regulates PNS and CNS Myelination through the Dlg1 Scaffold. PLoS Biol. 2016;14:e1002440 pubmed publisher..In summary, we propose a novel function for the Kif13b kinesin in glial cells as a key component of the PI3K/AKT signaling pathway, which controls myelination in both PNS and CNS. ..
- Magnaghi V, Ballabio M, Roglio I, Melcangi R. Progesterone derivatives increase expression of Krox-20 and Sox-10 in rat Schwann cells. J Mol Neurosci. 2007;31:149-57 pubmed
- Bolis A, Coviello S, Bussini S, Dina G, Pardini C, Previtali S, et al. Loss of Mtmr2 phosphatase in Schwann cells but not in motor neurons causes Charcot-Marie-Tooth type 4B1 neuropathy with myelin outfoldings. J Neurosci. 2005;25:8567-77 pubmed..Thus, therapeutical approaches might be designed in the future to specifically deliver the Mtmr2 phospholipid phosphatase to Schwann cells in affected nerves. ..
- Magnaghi V, Ballabio M, Cavarretta I, Froestl W, Lambert J, Zucchi I, et al. GABAB receptors in Schwann cells influence proliferation and myelin protein expression. Eur J Neurosci. 2004;19:2641-9 pubmed..e. glycoprotein Po, peripheral myelin protein 22, myelin-associated glycoprotein, connexin 32), providing evidence for a physiological role of GABA(B) receptors in the glial cells of the peripheral nervous system. ..
- Cavarretta I, Martini L, Motta M, Smith C, Melcangi R. SRC-1 is involved in the control of the gene expression of myelin protein Po. J Mol Neurosci. 2004;24:217-26 pubmed..Altogether, these data indicate for the first time that in rat Schwann cells, SRC-1 plays a role in the regulation of one of the most typical proteins of peripheral myelin. ..
- Giacomini C, La Padula V, Schenone A, Leandri M, Contestabile A, Moruzzo D, et al. Both Schwann cell and axonal defects cause motor peripheral neuropathy in Ebf2-/- mice. Neurobiol Dis. 2011;42:73-84 pubmed publisher..These findings demonstrate that Ebf2 is a new molecule implicated in peripheral nerve development and a potential candidate gene for peripheral nerve disorders. ..
- Roberts S, Dun X, Doddrell R, Mindos T, Drake L, Onaitis M, et al. Sox2 expression in Schwann cells inhibits myelination in vivo and induces influx of macrophages to the nerve. Development. 2017;144:3114-3125 pubmed publisher..These findings identify Sox2 as a physiological regulator of Schwann cell myelination in vivo and its potential to play a role in disorders of myelination in the peripheral nervous system. ..
- Espinosa Medina I, Outin E, Picard C, Chettouh Z, Dymecki S, Consalez G, et al. Neurodevelopment. Parasympathetic ganglia derive from Schwann cell precursors. Science. 2014;345:87-90 pubmed publisher..Thus, cranial Schwann cell precursors are the source of parasympathetic neurons during normal development. ..
- Porrello E, Rivellini C, Dina G, Triolo D, Del Carro U, Ungaro D, et al. Jab1 regulates Schwann cell proliferation and axonal sorting through p27. J Exp Med. 2014;211:29-43 pubmed publisher..Finally, Jab1 may constitute a key molecule in the pathogenesis of dysmyelinating neuropathies. ..
- Previtali S, Dina G, Nodari A, Fasolini M, Wrabetz L, Mayer U, et al. Schwann cells synthesize alpha7beta1 integrin which is dispensable for peripheral nerve development and myelination. Mol Cell Neurosci. 2003;23:210-8 pubmed..Nonetheless, these data taken together with the previous demonstration of impaired axonal regrowth in alpha7-null mice suggest a possible Schwann cell-autonomous role for alpha7 in nerve regeneration. ..
- Previtali S, Nodari A, Taveggia C, Pardini C, Dina G, Villa A, et al. Expression of laminin receptors in schwann cell differentiation: evidence for distinct roles. J Neurosci. 2003;23:5520-30 pubmed..These data suggest that the action of laminin is mediated by beta1 integrins during axonal sorting and by dystroglycan, alpha6beta1, and alpha6beta4 integrins during myelination. ..
- Triolo D, Dina G, Lorenzetti I, Malaguti M, Morana P, Del Carro U, et al. Loss of glial fibrillary acidic protein (GFAP) impairs Schwann cell proliferation and delays nerve regeneration after damage. J Cell Sci. 2006;119:3981-93 pubmed..GFAP might contribute to form macro-complexes to initiate mitogenic and differentiating signaling for efficient nerve regeneration. ..
- Bolino A, Bolis A, Previtali S, Dina G, Bussini S, Dati G, et al. Disruption of Mtmr2 produces CMT4B1-like neuropathy with myelin outfolding and impaired spermatogenesis. J Cell Biol. 2004;167:711-21 pubmed..We propose that Schwann cell-autonomous loss of Mtmr2-Dlg1 interaction dysregulates membrane homeostasis in the paranodal region, thereby producing outfolding and recurrent loops of myelin. ..
- Bolis A, Coviello S, Visigalli I, Taveggia C, Bachi A, Chishti A, et al. Dlg1, Sec8, and Mtmr2 regulate membrane homeostasis in Schwann cell myelination. J Neurosci. 2009;29:8858-70 pubmed publisher..Myelin outfoldings thus arise as a consequence of the loss of negative control on the amount of membrane, which is produced during myelination. ..
- Court F, Hewitt J, Davies K, Patton B, Uncini A, Wrabetz L, et al. A laminin-2, dystroglycan, utrophin axis is required for compartmentalization and elongation of myelin segments. J Neurosci. 2009;29:3908-19 pubmed publisher..Other cell types may exploit dystroglycan complexes in similar fashions to create barriers and compartments. ..
- Massa R, Palumbo C, Cavallaro T, Panico M, Bei R, Terracciano C, et al. Overexpression of ErbB2 and ErbB3 receptors in Schwann cells of patients with Charcot-Marie-tooth disease type 1A. Muscle Nerve. 2006;33:342-9 pubmed..The upregulation of these receptors may play a role in the inhibition of myelination or in the promotion of recurrent demyelination and axonal damage. ..
- Nodari A, Zambroni D, Quattrini A, Court F, D Urso A, Recchia A, et al. Beta1 integrin activates Rac1 in Schwann cells to generate radial lamellae during axonal sorting and myelination. J Cell Biol. 2007;177:1063-75 pubmed..Thus, increased activation of Rac1 by beta1 integrins allows Schwann cells to switch from migration/elongation to the extension of radial membranes required for axonal sorting and myelination...
- Panteri R, Mey J, Zhelyaznik N, D Altocolle A, Del Fa A, Gangitano C, et al. Reelin is transiently expressed in the peripheral nerve during development and is upregulated following nerve crush. Mol Cell Neurosci. 2006;32:133-42 pubmed..This indicates that Reelin may play a role in peripheral nervous system development and repair by regulating Schwann cell-axon interactions. ..
- Taveggia C, Pizzagalli A, Fagiani E, Messing A, Feltri M, Wrabetz L. Characterization of a Schwann cell enhancer in the myelin basic protein gene. J Neurochem. 2004;91:813-24 pubmed..Finally, chromatin context augments activation of MbpSCE1. Therefore, MbpSCE1 is active in both Schwann cells and oligodendrocytes, but by diverse mechanisms. ..
- Nobbio L, Sturla L, Fiorese F, Usai C, Basile G, Moreschi I, et al. P2X7-mediated increased intracellular calcium causes functional derangement in Schwann cells from rats with CMT1A neuropathy. J Biol Chem. 2009;284:23146-58 pubmed publisher..The development of P2X7 inhibitors is expected to provide a new therapeutic strategy for treatment of CMT1A neuropathy. ..
- Nobbio L, Fiorese F, Vigo T, Cilli M, Gherardi G, Grandis M, et al. Impaired expression of ciliary neurotrophic factor in Charcot-Marie-Tooth type 1A neuropathy. J Neuropathol Exp Neurol. 2009;68:441-55 pubmed publisher..Moreover, the observations suggest that trophic support to the axon is impaired in CMT1A and that further studies on the therapeutic use of trophic factors or their derivatives in experimental and human CMT1A are warranted. ..
- Previtali S, Zerega B, Sherman D, Brophy P, Dina G, King R, et al. Myotubularin-related 2 protein phosphatase and neurofilament light chain protein, both mutated in CMT neuropathies, interact in peripheral nerve. Hum Mol Genet. 2003;12:1713-23 pubmed
- Zaratin P, Quattrini A, Previtali S, Comi G, Hervieu G, Scheideler M. Schwann cell overexpression of the GPR7 receptor in inflammatory and painful neuropathies. Mol Cell Neurosci. 2005;28:55-63 pubmed..These results suggest a relationship between the pathogenesis of inflammatory/immune-mediated neuropathies, GPR7 receptor expression, and pain transmission. ..
- Feltri M, Graus Porta D, Previtali S, Nodari A, Migliavacca B, Cassetti A, et al. Conditional disruption of beta 1 integrin in Schwann cells impedes interactions with axons. J Cell Biol. 2002;156:199-209 pubmed
- Previtali S, Quattrini A, Bolino A. Charcot-Marie-Tooth type 4B demyelinating neuropathy: deciphering the role of MTMR phosphatases. Expert Rev Mol Med. 2007;9:1-16 pubmed..In this review, we discuss recent findings on this interesting protein family with the main focus on MTMR2 and MTMR13 and their involvement in the biology of Schwann cell and CMT4B neuropathies. ..
- Menichella D, Arroyo E, Awatramani R, Xu T, Baron P, Vallat J, et al. Protein zero is necessary for E-cadherin-mediated adherens junction formation in Schwann cells. Mol Cell Neurosci. 2001;18:606-18 pubmed..Interestingly, axoglial junction formation is normal in P0(-/-) nerve. Taken together, these data demonstrate that P0 is necessary for the formation of adherens junctions but not axoglial junctions in myelinating Schwann cells. ..
- Menichella D, Xu W, Jiang H, Sohi J, Vallat J, Baron P, et al. The absence of myelin P0 protein produces a novel molecular phenotype in Schwann cells. Ann N Y Acad Sci. 1999;883:281-93 pubmed