Experts and Doctors on ryanodine receptor calcium release channel in United States


Locale: United States
Topic: ryanodine receptor calcium release channel

Top Publications

  1. Kobayashi S, Yamamoto T, Parness J, Ikemoto N. Antibody probe study of Ca2+ channel regulation by interdomain interaction within the ryanodine receptor. Biochem J. 2004;380:561-9 pubmed
  2. Gangopadhyay J, Grabarek Z, Ikemoto N. Fluorescence probe study of Ca2+-dependent interactions of calmodulin with calmodulin-binding peptides of the ryanodine receptor. Biochem Biophys Res Commun. 2004;323:760-8 pubmed
    ..Based on our results we propose that both the interaction interface and the global conformation of the CaM-CaMBP complex are altered by calcium. ..
  3. Katra R, Laurita K. Cellular mechanism of calcium-mediated triggered activity in the heart. Circ Res. 2005;96:535-42 pubmed
    ..Finally, multiple SCR events may be a mechanism of polymorphic VT under calcium overload conditions. ..
  4. Belevych A, Terentyev D, Viatchenko Karpinski S, Terentyeva R, Sridhar A, Nishijima Y, et al. Redox modification of ryanodine receptors underlies calcium alternans in a canine model of sudden cardiac death. Cardiovasc Res. 2009;84:387-95 pubmed publisher
    ..Redox modulation of RyRs promotes generation of Ca(2+) alternans by enhancing the steepness of the Ca(2+) release-load relationship and thereby providing a substrate for post-MI arrhythmias...
  5. Jiang M, Lokuta A, Farrell E, Wolff M, Haworth R, Valdivia H. Abnormal Ca2+ release, but normal ryanodine receptors, in canine and human heart failure. Circ Res. 2002;91:1015-22 pubmed
    ..These results support a role for SR in the pathogenesis of HF, with abnormal Ca2+ uptake, more than Ca2+ release, contributing to the depressed and slow Ca2+ transient characteristic of HF. ..
  6. Terentyev D, Nori A, Santoro M, Viatchenko Karpinski S, Kubalova Z, Gyorke I, et al. Abnormal interactions of calsequestrin with the ryanodine receptor calcium release channel complex linked to exercise-induced sudden cardiac death. Circ Res. 2006;98:1151-8 pubmed
    ..These results show that intracellular Ca2+ cycling in normal heart relies on an intricate interplay of CASQ2 with the proteins of the RyR2 channel complex and that disruption of these interactions can lead to cardiac arrhythmia. ..
  7. Meng X, Xiao B, Cai S, Huang X, Li F, Bolstad J, et al. Three-dimensional localization of serine 2808, a phosphorylation site in cardiac ryanodine receptor. J Biol Chem. 2007;282:25929-39 pubmed
    ..6 binding site mapped previously, indicating that Ser-2808 is unlikely to be directly involved in the binding of FKBP12.6 to RyR2, as had been proposed previously. ..
  8. Bannister R, Grabner M, Beam K. The alpha(1S) III-IV loop influences 1,4-dihydropyridine receptor gating but is not directly involved in excitation-contraction coupling interactions with the type 1 ryanodine receptor. J Biol Chem. 2008;283:23217-23 pubmed publisher
    ..Taken together, our observations indicate that the alpha(1S) III-IV loop is not directly involved in EC coupling but does influence DHPR gating transitions important both for EC coupling and activation of L-type conductance. ..
  9. Bhat M, Hayek S, Zhao J, Zang W, Takeshima H, Wier W, et al. Expression and functional characterization of the cardiac muscle ryanodine receptor Ca(2+) release channel in Chinese hamster ovary cells. Biophys J. 1999;77:808-16 pubmed

More Information

Publications143 found, 100 shown here

  1. Straub S, Giovannucci D, Yule D. Calcium wave propagation in pancreatic acinar cells: functional interaction of inositol 1,4,5-trisphosphate receptors, ryanodine receptors, and mitochondria. J Gen Physiol. 2000;116:547-60 pubmed
    ..In addition, mitochondrial Ca(2+) import controls the spread of Ca(2+) throughout acinar cells by modulating RyR activation. ..
  2. Pan Z, Bhat M, Nieminen A, Ma J. Synergistic movements of Ca(2+) and Bax in cells undergoing apoptosis. J Biol Chem. 2001;276:32257-63 pubmed
    ..This dynamic interplay of Ca(2+) and Bax movements may serve as an amplifying factor in the initial signaling steps of apoptosis. ..
  3. Albrecht M, Colegrove S, Hongpaisan J, Pivovarova N, Andrews S, Friel D. Multiple modes of calcium-induced calcium release in sympathetic neurons I: attenuation of endoplasmic reticulum Ca2+ accumulation at low [Ca2+](i) during weak depolarization. J Gen Physiol. 2001;118:83-100 pubmed
    ..These results emphasize the importance of the relative rates of Ca2+ uptake and release in defining ER contributions to depolarization-induced Ca2+ signals. ..
  4. Dirksen R, Avila G. Distinct effects on Ca2+ handling caused by malignant hyperthermia and central core disease mutations in RyR1. Biophys J. 2004;87:3193-204 pubmed
  5. Kalyanasundaram A, Viatchenko Karpinski S, Belevych A, Lacombe V, Hwang H, Knollmann B, et al. Functional consequences of stably expressing a mutant calsequestrin (CASQ2D307H) in the CASQ2 null background. Am J Physiol Heart Circ Physiol. 2012;302:H253-61 pubmed publisher
    ..We propose that poor interaction between CASQ2(D307H) and triadin 1 could affect ryanodine receptor 2 stability, thereby increasing susceptibility to delayed afterdepolarizations and triggered arrhythmic activity. ..
  6. Ye Y, Yaeger D, Owen L, Escobedo J, Wang J, Singer J, et al. Designing calcium release channel inhibitors with enhanced electron donor properties: stabilizing the closed state of ryanodine receptor type 1. Mol Pharmacol. 2012;81:53-62 pubmed publisher
    ..This is a novel approach to the design of new, more potent drugs with the aim of functionally modifying RyR1 single-channel activity. ..
  7. Brunello L, Slabaugh J, Radwanski P, Ho H, Belevych A, Lou Q, et al. Decreased RyR2 refractoriness determines myocardial synchronization of aberrant Ca2+ release in a genetic model of arrhythmia. Proc Natl Acad Sci U S A. 2013;110:10312-7 pubmed publisher
    ..Our study reveals how aberrant DCR events can become synchronized in the intact myocardium, leading to triggered activity and the resultant DCs in the settings of a cardiac rhythm disorder. ..
  8. Lokuta A, Darszon A, Beltran C, Valdivia H. Detection and functional characterization of ryanodine receptors from sea urchin eggs. J Physiol. 1998;510 ( Pt 1):155-64 pubmed
    ..5. These findings suggest that a functional Ca2+ release unit in sea urchin eggs is a complex of several molecules, one of which corresponds to a protein functionally similar to mammalian RyRs. ..
  9. Bruce J, Shuttleworth T, Giovannucci D, Yule D. Phosphorylation of inositol 1,4,5-trisphosphate receptors in parotid acinar cells. A mechanism for the synergistic effects of cAMP on Ca2+ signaling. J Biol Chem. 2002;277:1340-8 pubmed
    ..In addition, this report supports the emerging consensus that phosphorylation at the level of the Ca(2+) release machinery is a broadly important mechanism by which cells can regulate Ca(2+)-mediated processes. ..
  10. Chan S, Mayne M, Holden C, Geiger J, Mattson M. Presenilin-1 mutations increase levels of ryanodine receptors and calcium release in PC12 cells and cortical neurons. J Biol Chem. 2000;275:18195-200 pubmed
  11. Fill M, Zahradnikova A, Villalba Galea C, Zahradnik I, Escobar A, Gyorke S. Ryanodine receptor adaptation. J Gen Physiol. 2000;116:873-82 pubmed
  12. Mitra P, Slaughter M. Calcium-induced transitions between the spontaneous miniature outward and the transient outward currents in retinal amacrine cells. J Gen Physiol. 2002;119:373-88 pubmed
    ..Based on their characteristics, SMOCs in retinal neurons may function as synaptic noise suppressors at quiescent glutamatergic synapses...
  13. Bers D. Cardiac ryanodine receptor phosphorylation: target sites and functional consequences. Biochem J. 2006;396:e1-3 pubmed
    ..This study brings some new answers, but also raises additional new questions that will require further investigation. ..
  14. Song Y, Shryock J, Belardinelli L. An increase of late sodium current induces delayed afterdepolarizations and sustained triggered activity in atrial myocytes. Am J Physiol Heart Circ Physiol. 2008;294:H2031-9 pubmed publisher
    ..The data reveal that an increase of late I(Na) is a novel mechanism for initiation of atrial arrhythmic activity. ..
  15. Hristov K, Cui X, Brown S, Liu L, Kellett W, Petkov G. Stimulation of beta3-adrenoceptors relaxes rat urinary bladder smooth muscle via activation of the large-conductance Ca2+-activated K+ channels. Am J Physiol Cell Physiol. 2008;295:C1344-53 pubmed publisher
    ..The data indicate that stimulation of beta3-AR relaxes rat UBSM by increasing the BK channel STOC frequency, which causes membrane hyperpolarization and thus relaxation. ..
  16. Gangopadhyay J, Ikemoto N. Intracellular translocation of calmodulin and Ca2+/calmodulin-dependent protein kinase II during the development of hypertrophy in neonatal cardiomyocytes. Biochem Biophys Res Commun. 2010;396:515-21 pubmed publisher
  17. Dabertrand F, Nelson M, Brayden J. Ryanodine receptors, calcium signaling, and regulation of vascular tone in the cerebral parenchymal microcirculation. Microcirculation. 2013;20:307-16 pubmed publisher
    ..Here, we summarize the roles of ryanodine receptors in the parenchymal microvasculature under physiologic and pathologic conditions, and discuss their importance in the control of CBF. ..
  18. Herrera G, Heppner T, Nelson M. Regulation of urinary bladder smooth muscle contractions by ryanodine receptors and BK and SK channels. Am J Physiol Regul Integr Comp Physiol. 2000;279:R60-8 pubmed
    ..RyRs also appear to play a significant role as a negative feedback regulator of contraction frequency and duration, and this role is influenced by the activity of SK channels...
  19. Beutner G, Sharma V, Giovannucci D, Yule D, Sheu S. Identification of a ryanodine receptor in rat heart mitochondria. J Biol Chem. 2001;276:21482-8 pubmed
    ..This mitochondrial ryanodine receptor is likely to play an essential role in the dynamic uptake of Ca(2+) into mitochondria during Ca(2+) oscillations. ..
  20. Chini E. Selected contribution: effect of volatile anesthetics on cADP-ribose-induced Ca(2+) release system. J Appl Physiol (1985). 2001;91:516-21; discussion 504-5 pubmed
    ..I propose that the complex effect of volatile anesthetics on intracellular Ca(2+) homeostasis may involve modulation of the cADPR signaling system...
  21. Kobayashi S, Bannister M, Gangopadhyay J, Hamada T, Parness J, Ikemoto N. Dantrolene stabilizes domain interactions within the ryanodine receptor. J Biol Chem. 2005;280:6580-7 pubmed
    ..We suggest that temperature and calmodulin primarily affect the coupling between the domain switch and the downstream mechanism of regulation of Ca(2+) channel opening rather than the domain switch itself. ..
  22. Tang F, Kalil K. Netrin-1 induces axon branching in developing cortical neurons by frequency-dependent calcium signaling pathways. J Neurosci. 2005;25:6702-15 pubmed
    ..Together, these novel findings define calcium signaling mechanisms required for development of new axon branches promoted by a guidance cue. ..
  23. Shen J, Yu W, Brotto M, Scherman J, Guo C, Stoddard C, et al. Deficiency of MIP/MTMR14 phosphatase induces a muscle disorder by disrupting Ca(2+) homeostasis. Nat Cell Biol. 2009;11:769-76 pubmed publisher
    ..These studies provide the first evidence that finely controlled PtdInsP levels in muscle cells are essential for maintaining Ca(2+) homeostasis and muscle performance. ..
  24. Gangopadhyay J, Ikemoto N. Aberrant interaction of calmodulin with the ryanodine receptor develops hypertrophy in the neonatal cardiomyocyte. Biochem J. 2011;438:379-87 pubmed publisher
    ..These results indicate that the aberrant formation of the activation link between CaMBD and CaMLD of RyR is a key step in the development of hypertrophy in cultured cardiomyocytes. ..
  25. Hohman T, Bush W, Jiang L, Brown Gentry K, Torstenson E, Dudek S, et al. Discovery of gene-gene interactions across multiple independent data sets of late onset Alzheimer disease from the Alzheimer Disease Genetics Consortium. Neurobiol Aging. 2016;38:141-150 pubmed publisher
    ..Further, our results highlight the utility of evaluating genetic interactions to explain additional variance in AD risk and identify novel molecular mechanisms of AD pathogenesis. ..
  26. Xin W, Soder R, Cheng Q, Rovner E, Petkov G. Selective inhibition of phosphodiesterase 1 relaxes urinary bladder smooth muscle: role for ryanodine receptor-mediated BK channel activation. Am J Physiol Cell Physiol. 2012;303:C1079-89 pubmed publisher
  27. Hayoz S, Bradley V, Boerman E, Nourian Z, Segal S, Jackson W. Aging increases capacitance and spontaneous transient outward current amplitude of smooth muscle cells from murine superior epigastric arteries. Am J Physiol Heart Circ Physiol. 2014;306:H1512-24 pubmed publisher
    ..05). Enhanced functional expression of SMC BKCa-dependent STOCs in Old may represent an adaptation of resistance arteries to maintain functional integrity. ..
  28. Samso M, Wagenknecht T. Apocalmodulin and Ca2+-calmodulin bind to neighboring locations on the ryanodine receptor. J Biol Chem. 2002;277:1349-53 pubmed
    ..The locations of apoCaM and Ca(2+)-CaM at a critical region for RYR1-dihydropyridine receptor interaction are suggestive of a direct role for CaM in the mechanism of excitation-contraction coupling. ..
  29. Bovo E, Mazurek S, Blatter L, Zima A. Regulation of sarcoplasmic reticulum Ca²? leak by cytosolic Ca²? in rabbit ventricular myocytes. J Physiol. 2011;589:6039-50 pubmed publisher
    ..As RyR activity depends highly on [Ca(2+)](i) and [Ca(2+)](SR), SR Ca(2+) leak remains relatively constant during the declining phase of the Ca(2+) transient when [Ca(2+)](SR) and [Ca(2+)](i) change in opposite directions. ..
  30. Zhang F, Jin S, Yi F, Xia M, Dewey W, Li P. Local production of O2- by NAD(P)H oxidase in the sarcoplasmic reticulum of coronary arterial myocytes: cADPR-mediated Ca2+ regulation. Cell Signal. 2008;20:637-44 pubmed publisher
    ..These results provide direct evidence that O2- could be locally produced via NOX on the SR and that this local O2- producing system is controlled by cADPR-RyR/Ca2+ signaling pathway. ..
  31. Wang H, Ward N, Boswell M, Katz D. Secretion of brain-derived neurotrophic factor from brain microvascular endothelial cells. Eur J Neurosci. 2006;23:1665-70 pubmed
    ..3 cells respond to oxidative stress by increasing BDNF secretion and, in addition, highlight TRP channels as potential therapeutic targets for enhancing BDNF availability from the cerebral microvasculature. ..
  32. Cutler M, Plummer B, Wan X, Sun Q, Hess D, Liu H, et al. Aberrant S-nitrosylation mediates calcium-triggered ventricular arrhythmia in the intact heart. Proc Natl Acad Sci U S A. 2012;109:18186-91 pubmed publisher
    ..e., elevated [Ca(2+)](i) and oxidative stress), and that therapies restoring nitroso-redox balance in the heart could prevent sudden arrhythmic death. ..
  33. Altschafl B, Beutner G, Sharma V, Sheu S, Valdivia H. The mitochondrial ryanodine receptor in rat heart: a pharmaco-kinetic profile. Biochim Biophys Acta. 2007;1768:1784-95 pubmed
    ..These results therefore provide the first direct evidence that a unique RyR occurs in mitochondrial membranes. ..
  34. Diaz Sylvester P, Porta M, Copello J. Modulation of cardiac ryanodine receptor channels by alkaline earth cations. PLoS ONE. 2011;6:e26693 pubmed publisher
    ..In summary, RyR2 luminal and cytosolic surfaces have at least two sets of M(2+) binding sites (specific for Ca(2+) and unspecific for Ca(2+)/Mg(2+)) that dynamically modulate channel activity and gating status, depending on SR voltage...
  35. Kettlun C, Gonzalez A, Rios E, Fill M. Unitary Ca2+ current through mammalian cardiac and amphibian skeletal muscle ryanodine receptor Channels under near-physiological ionic conditions. J Gen Physiol. 2003;122:407-17 pubmed
  36. Wan X, Laurita K, Pruvot E, Rosenbaum D. Molecular correlates of repolarization alternans in cardiac myocytes. J Mol Cell Cardiol. 2005;39:419-28 pubmed
    ..Moreover, transmural differences in expression and function of key SR Ca(2+) cycling proteins may underlie spatial heterogeneity of APD-ALT that has been closely linked to cardiac arrhythmogenesis. ..
  37. Chen Izu Y, Ward C, Stark W, Banyasz T, Sumandea M, Balke C, et al. Phosphorylation of RyR2 and shortening of RyR2 cluster spacing in spontaneously hypertensive rat with heart failure. Am J Physiol Heart Circ Physiol. 2007;293:H2409-17 pubmed
    ..Furthermore, the spacing between RyR(2) clusters was shortened in failing hearts, as predicted by quantitative model simulation to increase spontaneous Ca(2+) wave generation and arrhythmias. ..
  38. Huke S, Bers D. Ryanodine receptor phosphorylation at Serine 2030, 2808 and 2814 in rat cardiomyocytes. Biochem Biophys Res Commun. 2008;376:80-5 pubmed publisher
    ..Phosphatase 1 appears to be the main phosphatase dephosphorylating S2808/S2814, but phosphatase 2a may also dephosphorylate S2814. RyR phosphorylation is complex, but important in understanding RyR functional modulation. ..
  39. Oestreich E, Malik S, Goonasekera S, Blaxall B, Kelley G, Dirksen R, et al. Epac and phospholipase Cepsilon regulate Ca2+ release in the heart by activation of protein kinase Cepsilon and calcium-calmodulin kinase II. J Biol Chem. 2009;284:1514-22 pubmed publisher
  40. Perry S, Barbieri J, Tong N, Polesskaya O, Pudasaini S, Stout A, et al. Human immunodeficiency virus-1 Tat activates calpain proteases via the ryanodine receptor to enhance surface dopamine transporter levels and increase transporter-specific uptake and Vmax. J Neurosci. 2010;30:14153-64 pubmed publisher
    ..Finally, we provide key translational relevance for these findings by highlighting published human data of increased DAT levels in striata of HAND patients and by demonstrating similar findings in Tat-expressing transgenic mice. ..
  41. Wu Y, Valdivia H, Wehrens X, Anderson M. A Single Protein Kinase A or Calmodulin Kinase II Site Does Not Control the Cardiac Pacemaker Ca2+ Clock. Circ Arrhythm Electrophysiol. 2016;9:e003180 pubmed publisher
    ..PKA and CaMKII do not affect HR by a unique target site governing SR Ca(2+) uptake or release. HR acceleration may require an SR Ca(2+) content threshold. ..
  42. Pierobon N, Renard Rooney D, Gaspers L, Thomas A. Ryanodine receptors in liver. J Biol Chem. 2006;281:34086-95 pubmed
    ..We propose that the Ca2+ released from ryanodine receptors on the endoplasmic reticulum provides an increased pool of Ca2+ for positive feedback on inositol 1,4,5-trisphosphate receptors. ..
  43. Selby T, Lahm G, Stevenson T, Hughes K, Cordova D, Annan I, et al. Discovery of cyantraniliprole, a potent and selective anthranilic diamide ryanodine receptor activator with cross-spectrum insecticidal activity. Bioorg Med Chem Lett. 2013;23:6341-5 pubmed publisher
    ..Here we report on the chemistry, biology and structure-activity trends for a series of cyanoanthranilic diamides from which cyantraniliprole was selected for commercial development. ..
  44. Fessenden J. Förster resonance energy transfer measurements of ryanodine receptor type 1 structure using a novel site-specific labeling method. PLoS ONE. 2009;4:e7338 pubmed publisher
    ..These findings illustrate the potential of this site-specific labeling system for use in future FRET-based experiments to elucidate novel aspects of RyR1 structure. ..
  45. Liao B, Zheng Y, Yadav V, Korde A, Wang Y. Hypoxia induces intracellular Ca2+ release by causing reactive oxygen species-mediated dissociation of FK506-binding protein 12.6 from ryanodine receptor 2 in pulmonary artery myocytes. Antioxid Redox Signal. 2011;14:37-47 pubmed publisher
    ..6 removal enhanced, whereas RyR2 gene deletion blocked the hypoxic increase in [Ca(2+)](i) in PASMCs. Collectively, we conclude that hypoxia may induce Ca(2+) release by causing ROS-mediated dissociation of FKBP12.6 from RyR2 in PASMCs. ..
  46. Koide M, Nystoriak M, Krishnamoorthy G, O Connor K, Bonev A, Nelson M, et al. Reduced Ca2+ spark activity after subarachnoid hemorrhage disables BK channel control of cerebral artery tone. J Cereb Blood Flow Metab. 2011;31:3-16 pubmed publisher
    ..This phenomenon may contribute to decreased cerebral blood flow and poor outcome after aneurysmal SAH. ..
  47. Gant J, Chen K, Norris C, Kadish I, Thibault O, Blalock E, et al. Disrupting function of FK506-binding protein 1b/12.6 induces the Ca²+-dysregulation aging phenotype in hippocampal neurons. J Neurosci. 2011;31:1693-703 pubmed publisher
    ..Thus, disruption of FKBP1b recapitulated much of the Ca(2+)-dysregulation aging phenotype in young rat hippocampus, supporting a novel hypothesis that declining FKBP function plays a major role in unhealthy brain aging. ..
  48. Bal N, Maurya S, Sopariwala D, Sahoo S, Gupta S, Shaikh S, et al. Sarcolipin is a newly identified regulator of muscle-based thermogenesis in mammals. Nat Med. 2012;18:1575-9 pubmed publisher
    ..These data collectively suggest that SLN is an important mediator of muscle thermogenesis and whole-body energy metabolism...
  49. Ruehr M, Russell M, Ferguson D, Bhat M, Ma J, Damron D, et al. Targeting of protein kinase A by muscle A kinase-anchoring protein (mAKAP) regulates phosphorylation and function of the skeletal muscle ryanodine receptor. J Biol Chem. 2003;278:24831-6 pubmed
    ..Therefore, RyR1 function is regulated by mAKAP targeting of PKA, implying an important functional role for PKA phosphorylation of RyR in skeletal muscle. ..
  50. Huke S, Bers D. Temporal dissociation of frequency-dependent acceleration of relaxation and protein phosphorylation by CaMKII. J Mol Cell Cardiol. 2007;42:590-9 pubmed
  51. Snopko R, Ramos Franco J, Di Maio A, Karko K, Manley C, Piedras Rentería E, et al. Ca2+ sparks and cellular distribution of ryanodine receptors in developing cardiomyocytes from rat. J Mol Cell Cardiol. 2008;44:1032-44 pubmed publisher
  52. Liu Y, Korte F, Moussavi Harami F, Yu M, Razumova M, Regnier M, et al. Transcription factor CHF1/Hey2 regulates EC coupling and heart failure in mice through regulation of FKBP12.6. Am J Physiol Heart Circ Physiol. 2012;302:H1860-70 pubmed publisher
    ..These findings demonstrate that conditional deletion of CHF1/Hey2 in the myocardium leads to abnormalities in calcium handling mediated by FKBP12.6 that predispose to pressure overload-induced heart failure. ..
  53. Lesiak A, Zhu M, Chen H, Appleyard S, Impey S, Lein P, et al. The environmental neurotoxicant PCB 95 promotes synaptogenesis via ryanodine receptor-dependent miR132 upregulation. J Neurosci. 2014;34:717-25 pubmed publisher
    ..In light of recent evidence implicating miR132 dysregulation in Rett syndrome and schizophrenia, these findings identify NDL PCBs as potential environmental risk factors for neurodevelopmental disorders. ..
  54. Gomez A, Yamaguchi N. Two regions of the ryanodine receptor calcium channel are involved in Ca(2+)-dependent inactivation. Biochemistry. 2014;53:1373-9 pubmed publisher
  55. Bers D, Li L, Satoh H, McCall E. Factors that control sarcoplasmic reticulum calcium release in intact ventricular myocytes. Ann N Y Acad Sci. 1998;853:157-77 pubmed
    ..Thus the regulation of the SR Ca release channel in the intact cell is an important factor in cellular cardiac function. ..
  56. Farrell E, Antaramian A, Rueda A, Gomez A, Valdivia H. Sorcin inhibits calcium release and modulates excitation-contraction coupling in the heart. J Biol Chem. 2003;278:34660-6 pubmed
    ..Thus, sorcin is a potent inhibitor of both spontaneous and ICa-triggered RyR activity and is kinetically capable of playing a role in terminating the positive feedback loop of CICR. ..
  57. Graves T, Hinkle P. Ca(2+)-induced Ca(2+) release in the pancreatic beta-cell: direct evidence of endoplasmic reticulum Ca(2+) release. Endocrinology. 2003;144:3565-74 pubmed
    ..Taken together, these results provide strong evidence that Ca(2+)-induced Ca(2+) release augments cytoplasmic Ca(2+) signals in pancreatic beta-cells. ..
  58. Kim Y, Kim S, Yatani A, Huang Y, Castelli G, Vatner D, et al. Mechanism of enhanced cardiac function in mice with hypertrophy induced by overexpressed Akt. J Biol Chem. 2003;278:47622-8 pubmed
  59. Meadows L, Isom L. Sodium channels as macromolecular complexes: implications for inherited arrhythmia syndromes. Cardiovasc Res. 2005;67:448-58 pubmed
  60. Liu Q, Chen B, Yankova M, Morest D, Maryon E, Hand A, et al. Presynaptic ryanodine receptors are required for normal quantal size at the Caenorhabditis elegans neuromuscular junction. J Neurosci. 2005;25:6745-54 pubmed
    ..These observations suggest that RYRs are essential to normal quantal size and are potential regulators of quantal size. ..
  61. Wangemann P. Cochlear blood flow regulation. Adv Otorhinolaryngol. 2002;59:51-7 pubmed
  62. Nickels T, Schwartz A, Blevins D, Drummond J, Reed G, Wilson D. Effect of theophylline and aminophylline on transmitter release at the mammalian neuromuscular junction is not mediated by cAMP. Clin Exp Pharmacol Physiol. 2006;33:465-70 pubmed
    ..4. Taken together, these results indicate that the use of theophylline and aminophylline is inappropriate when examining the role of cAMP at the mammalian neuromuscular junction...
  63. Garic Stankovic A, Hernandez M, Flentke G, Zile M, Smith S. A ryanodine receptor-dependent Ca(i)(2+) asymmetry at Hensen's node mediates avian lateral identity. Development. 2008;135:3271-80 pubmed publisher
    ..Thus, Ca(i)(2+) asymmetry across the node represents a more broadly conserved mechanism for laterality among amniotes than had been previously believed. ..
  64. Watson G, Mire P, Hudson R. Frequency specificity of vibration dependent discharge of nematocysts in sea anemones. J Exp Zool. 1998;281:582-93 pubmed
    ..We propose that calcium induced calcium release (CICR) via ryanodine receptors may sharpen frequency specificity and/or cause shortening of hair bundles to shift frequency specificity to higher frequencies. ..
  65. Gao Z, Joseph E, Ruden D, Lu X. Drosophila Pkd2 is haploid-insufficient for mediating optimal smooth muscle contractility. J Biol Chem. 2004;279:14225-31 pubmed
  66. Berrout J, Isokawa M. Homeostatic and stimulus-induced coupling of the L-type Ca2+ channel to the ryanodine receptor in the hippocampal neuron in slices. Cell Calcium. 2009;46:30-8 pubmed publisher
  67. Zhao Z, Wen H, Fefelova N, Allen C, Baba A, Matsuda T, et al. Revisiting the ionic mechanisms of early afterdepolarizations in cardiomyocytes: predominant by Ca waves or Ca currents?. Am J Physiol Heart Circ Physiol. 2012;302:H1636-44 pubmed publisher
  68. Takano K, Liu D, Tarpey P, Gallant E, Lam A, Witham S, et al. An X-linked channelopathy with cardiomegaly due to a CLIC2 mutation enhancing ryanodine receptor channel activity. Hum Mol Genet. 2012;21:4497-507 pubmed
    ..Therefore, our patients appear to suffer from a new channelopathy comprised of ID, seizures and cardiac problems because of enhanced Ca(2+) release through RyRs in neuronal cells and cardiac muscle cells. ..
  69. Zima A, Kockskamper J, Mejia Alvarez R, Blatter L. Pyruvate modulates cardiac sarcoplasmic reticulum Ca2+ release in rats via mitochondria-dependent and -independent mechanisms. J Physiol. 2003;550:765-83 pubmed
    ..The latter effect was most probably mediated by an enhanced SR Ca2+ uptake due to an augmentation of mitochondria-dependent ATP synthesis. ..
  70. Cudd L, Clarke C, Clinkenbeard K. Contribution of intracellular calcium stores to an increase in cytosolic calcium concentration induced by Mannheimia haemolytica leukotoxin. FEMS Microbiol Lett. 2003;225:23-7 pubmed
  71. Pérez C, Copello J, Li Y, Karko K, Gómez L, Ramos Franco J, et al. Ryanodine receptor function in newborn rat heart. Am J Physiol Heart Circ Physiol. 2005;288:H2527-40 pubmed
  72. Hamada T, Bannister M, Ikemoto N. Peptide probe study of the role of interaction between the cytoplasmic and transmembrane domains of the ryanodine receptor in the channel regulation mechanism. Biochemistry. 2007;46:4272-9 pubmed
    ..In further support of this concept, anti-DP15 antibody and cardiac counterpart of DP15 produced channel activation similar to that of DP15. ..
  73. Xu X, Bhat M, Nishi M, Takeshima H, Ma J. Molecular cloning of cDNA encoding a drosophila ryanodine receptor and functional studies of the carboxyl-terminal calcium release channel. Biophys J. 2000;78:1270-81 pubmed
  74. Kapiloff M, Jackson N, Airhart N. mAKAP and the ryanodine receptor are part of a multi-component signaling complex on the cardiomyocyte nuclear envelope. J Cell Sci. 2001;114:3167-76 pubmed
    ..By binding protein kinase A and ryanodine receptor, mAKAP may serve as the scaffold for a cAMP- and calcium ion-sensitive signaling complex. ..
  75. Guo T, Zhang T, Mestril R, Bers D. Ca2+/Calmodulin-dependent protein kinase II phosphorylation of ryanodine receptor does affect calcium sparks in mouse ventricular myocytes. Circ Res. 2006;99:398-406 pubmed
    ..Moreover, this may explain the enhanced SR diastolic Ca2+ leak and certain triggered arrhythmias seen in heart failure. ..
  76. Bannister M, Hamada T, Murayama T, Harvey P, Casarotto M, Dulhunty A, et al. Malignant hyperthermia mutation sites in the Leu2442-Pro2477 (DP4) region of RyR1 (ryanodine receptor 1) are clustered in a structurally and functionally definable area. Biochem J. 2007;401:333-9 pubmed
    ..The data in the present paper indicates that mutation of residues in this region disrupts the interdomain interactions that stabilize the closed state of the channel...
  77. Lahm G, Cordova D, Barry J. New and selective ryanodine receptor activators for insect control. Bioorg Med Chem. 2009;17:4127-33 pubmed publisher
    ..The high levels of mammalian safety are attributed to a strong selectivity for insect over mammalian receptors. ..
  78. Wang H, Viatchenko Karpinski S, Sun J, Gyorke I, Benkusky N, Kohr M, et al. Regulation of myocyte contraction via neuronal nitric oxide synthase: role of ryanodine receptor S-nitrosylation. J Physiol. 2010;588:2905-17 pubmed publisher
    ..These data suggest that NOS1 signalling increases RyR2 activity via S-nitrosylation, which contributes to the NOS1-induced positive inotropic effect. Thus, RyR2 is an important end target of NOS1. ..
  79. Porta M, Diaz Sylvester P, Neumann J, Escobar A, Fleischer S, Copello J. Coupled gating of skeletal muscle ryanodine receptors is modulated by Ca2+, Mg2+, and ATP. Am J Physiol Cell Physiol. 2012;303:C682-97 pubmed publisher
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    ..RyR2 is the major binding site for CaM along the Z-line in cardiomyocytes, and dissociating CaM from RyR2 can cause severe ventricular arrhythmia. In heart failure, RyR2 shows decreased CaM affinity, but unaltered FKBP 12.6 affinity. ..
  81. Terentyev D, Cala S, Houle T, Viatchenko Karpinski S, Gyorke I, Terentyeva R, et al. Triadin overexpression stimulates excitation-contraction coupling and increases predisposition to cellular arrhythmia in cardiac myocytes. Circ Res. 2005;96:651-8 pubmed
    ..We conclude that TRD enhances cardiac excitation-contraction coupling by directly stimulating the RyR2. Interaction of TRD with RyR2 may involve amino acids 200 to 224 in C-terminal domain of TRD. ..
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    ..Overall, the data demonstrate that the His-Purkinje system is an important source of focal arrhythmias in catecholaminergic polymorphic VT. ..
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    ..We suggest that the sensitivity of RyR1 channel activity to CaM oxidation may function as part of an adaptive cellular response that enhances the duration of calcium transients to promote enhanced contractility. ..
  84. Terentyev D, Gyorke I, Belevych A, Terentyeva R, Sridhar A, Nishijima Y, et al. Redox modification of ryanodine receptors contributes to sarcoplasmic reticulum Ca2+ leak in chronic heart failure. Circ Res. 2008;103:1466-72 pubmed publisher
    ..These findings suggest that redox modification contributes to abnormal function of RyR2s in HF, presenting a potential therapeutic target for treating HF. ..
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    ..These data suggest that RyR1 is an important regulator of calcium signaling and that its physiological role in taste cells is dictated by the nature of the calcium signaling mechanisms expressed. ..
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    ..elegans body-wall myocytes generate all-or-none APs, which evoke Ca2+ release from the sarcoplasmic reticulum (SR), although the specific ion channels used for AP upstroke and repolarization differ...
  89. Ho H, Stevens S, Terentyeva R, Carnes C, Terentyev D, Gyorke S. Arrhythmogenic adverse effects of cardiac glycosides are mediated by redox modification of ryanodine receptors. J Physiol. 2011;589:4697-708 pubmed publisher
    ..These CG-dependent effects probably involve release of ROS from mitochondria possibly mediated by NADPH oxidase. ..
  90. Belevych A, Terentyev D, Terentyeva R, Ho H, Gyorke I, Bonilla I, et al. Shortened Ca2+ signaling refractoriness underlies cellular arrhythmogenesis in a postinfarction model of sudden cardiac death. Circ Res. 2012;110:569-77 pubmed publisher
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    ..Thus, physiological redox regulation of RyR1 by endogenously generated hydrogen peroxide is exerted through dynamic disulfide formation involving multiple Cys residues. ..
  92. Habib A, Karmali V, Polavarapu R, Akahori H, Cheng Q, Pachura K, et al. Sirolimus-FKBP12.6 impairs endothelial barrier function through protein kinase C-? activation and disruption of the p120-vascular endothelial cadherin interaction. Arterioscler Thromb Vasc Biol. 2013;33:2425-31 pubmed publisher
    ..These data suggest this mechanism may be an important contributor of SRL side effects related to impaired EBF. ..